-- dump date 20140619_154022 -- class Genbank::misc_feature -- table misc_feature_note -- id note 443149000001 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 443149000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443149000003 Walker A motif; other site 443149000004 ATP binding site [chemical binding]; other site 443149000005 Walker B motif; other site 443149000006 arginine finger; other site 443149000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 443149000008 DnaA box-binding interface [nucleotide binding]; other site 443149000009 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 443149000010 Transposase; Region: HTH_Tnp_1; cl17663 443149000011 putative transposase OrfB; Reviewed; Region: PHA02517 443149000012 HTH-like domain; Region: HTH_21; pfam13276 443149000013 Integrase core domain; Region: rve; pfam00665 443149000014 Integrase core domain; Region: rve_3; pfam13683 443149000015 DNA polymerase III subunit beta; Validated; Region: PRK07761 443149000016 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 443149000017 putative DNA binding surface [nucleotide binding]; other site 443149000018 dimer interface [polypeptide binding]; other site 443149000019 beta-clamp/clamp loader binding surface; other site 443149000020 beta-clamp/translesion DNA polymerase binding surface; other site 443149000021 recF protein; Region: recf; TIGR00611 443149000022 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 443149000023 Walker A/P-loop; other site 443149000024 ATP binding site [chemical binding]; other site 443149000025 Q-loop/lid; other site 443149000026 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443149000027 ABC transporter signature motif; other site 443149000028 Walker B; other site 443149000029 D-loop; other site 443149000030 H-loop/switch region; other site 443149000031 hypothetical protein; Provisional; Region: PRK03195 443149000032 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 443149000033 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443149000034 Mg2+ binding site [ion binding]; other site 443149000035 G-X-G motif; other site 443149000036 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 443149000037 anchoring element; other site 443149000038 dimer interface [polypeptide binding]; other site 443149000039 ATP binding site [chemical binding]; other site 443149000040 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 443149000041 active site 443149000042 putative metal-binding site [ion binding]; other site 443149000043 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 443149000044 DNA gyrase subunit A; Validated; Region: PRK05560 443149000045 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 443149000046 CAP-like domain; other site 443149000047 active site 443149000048 primary dimer interface [polypeptide binding]; other site 443149000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 443149000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 443149000051 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 443149000052 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 443149000053 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 443149000054 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 443149000055 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 443149000056 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 443149000057 Protein of unknown function (DUF2562); Region: DUF2562; pfam10814 443149000058 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 443149000059 active site 443149000060 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 443149000061 putative septation inhibitor protein; Reviewed; Region: PRK00159 443149000062 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 443149000063 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 443149000064 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 443149000065 Glutamine amidotransferase class-I; Region: GATase; pfam00117 443149000066 glutamine binding [chemical binding]; other site 443149000067 catalytic triad [active] 443149000068 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 443149000069 Catalytic domain of Protein Kinases; Region: PKc; cd00180 443149000070 active site 443149000071 ATP binding site [chemical binding]; other site 443149000072 substrate binding site [chemical binding]; other site 443149000073 activation loop (A-loop); other site 443149000074 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 443149000075 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 443149000076 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 443149000077 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 443149000078 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 443149000079 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 443149000080 Catalytic domain of Protein Kinases; Region: PKc; cd00180 443149000081 active site 443149000082 ATP binding site [chemical binding]; other site 443149000083 substrate binding site [chemical binding]; other site 443149000084 activation loop (A-loop); other site 443149000085 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 443149000086 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 443149000087 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 443149000088 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 443149000089 active site 443149000090 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 443149000091 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 443149000092 phosphopeptide binding site; other site 443149000093 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 443149000094 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 443149000095 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 443149000096 phosphopeptide binding site; other site 443149000097 Nitronate monooxygenase; Region: NMO; pfam03060 443149000098 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 443149000099 FMN binding site [chemical binding]; other site 443149000100 substrate binding site [chemical binding]; other site 443149000101 putative catalytic residue [active] 443149000102 Transcription factor WhiB; Region: Whib; pfam02467 443149000103 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 443149000104 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443149000105 non-specific DNA binding site [nucleotide binding]; other site 443149000106 salt bridge; other site 443149000107 sequence-specific DNA binding site [nucleotide binding]; other site 443149000108 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 443149000109 NlpC/P60 family; Region: NLPC_P60; pfam00877 443149000110 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 443149000111 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 443149000112 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 443149000113 Protein of unknown function (DUF2694); Region: DUF2694; pfam10904 443149000114 Protein of unknown function (DUF2710); Region: DUF2710; pfam10921 443149000115 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 443149000116 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 443149000117 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 443149000118 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443149000119 catalytic residue [active] 443149000120 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 443149000121 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 443149000122 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 443149000123 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 443149000124 acyl-activating enzyme (AAE) consensus motif; other site 443149000125 active site 443149000126 TIGR03084 family protein; Region: TIGR03084 443149000127 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 443149000128 Wyosine base formation; Region: Wyosine_form; pfam08608 443149000129 H+ Antiporter protein; Region: 2A0121; TIGR00900 443149000130 hypothetical protein; Validated; Region: PRK00228 443149000131 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 443149000132 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 443149000133 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 443149000134 active site 443149000135 HIGH motif; other site 443149000136 nucleotide binding site [chemical binding]; other site 443149000137 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 443149000138 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 443149000139 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 443149000140 active site 443149000141 KMSKS motif; other site 443149000142 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 443149000143 tRNA binding surface [nucleotide binding]; other site 443149000144 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 443149000145 MarR family; Region: MarR; pfam01047 443149000146 Transcriptional regulators [Transcription]; Region: FadR; COG2186 443149000147 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443149000148 DNA-binding site [nucleotide binding]; DNA binding site 443149000149 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 443149000150 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 443149000151 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 443149000152 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 443149000153 inositol 1-phosphate synthase, Actinobacterial type; Region: mycothiol_INO1; TIGR03450 443149000154 Predicted transcriptional regulators [Transcription]; Region: COG1695 443149000155 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 443149000156 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 443149000157 Transglycosylase; Region: Transgly; pfam00912 443149000158 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 443149000159 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 443149000160 Predicted integral membrane protein [Function unknown]; Region: COG5650 443149000161 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 443149000162 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 443149000163 conserved cys residue [active] 443149000164 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 443149000165 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 443149000166 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 443149000167 dimer interface [polypeptide binding]; other site 443149000168 ssDNA binding site [nucleotide binding]; other site 443149000169 tetramer (dimer of dimers) interface [polypeptide binding]; other site 443149000170 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 443149000171 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 443149000172 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 443149000173 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 443149000174 replicative DNA helicase; Validated; Region: PRK07773 443149000175 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 443149000176 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 443149000177 Walker A motif; other site 443149000178 ATP binding site [chemical binding]; other site 443149000179 Walker B motif; other site 443149000180 DNA binding loops [nucleotide binding] 443149000181 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 443149000182 protein-splicing catalytic site; other site 443149000183 thioester formation/cholesterol transfer; other site 443149000184 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 443149000185 protein-splicing catalytic site; other site 443149000186 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 443149000187 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 443149000188 ADP-ribose binding site [chemical binding]; other site 443149000189 Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1 [General function prediction only]; Region: COG2110 443149000190 Cellobiohydrolase A (1,4-beta-cellobiosidase A) [Carbohydrate transport and metabolism]; Region: CelA; COG5297 443149000191 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 443149000192 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 443149000193 FAD binding domain; Region: FAD_binding_4; pfam01565 443149000194 Berberine and berberine like; Region: BBE; pfam08031 443149000195 hypothetical protein; Provisional; Region: PRK12438 443149000196 hypothetical protein; Validated; Region: PRK00068 443149000197 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 443149000198 homotetrameric interface [polypeptide binding]; other site 443149000199 putative active site [active] 443149000200 metal binding site [ion binding]; metal-binding site 443149000201 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 443149000202 Monomeric isocitrate dehydrogenase; Region: IDH; pfam03971 443149000203 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149000204 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149000205 short chain dehydrogenase; Provisional; Region: PRK06197 443149000206 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 443149000207 putative NAD(P) binding site [chemical binding]; other site 443149000208 active site 443149000209 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 443149000210 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 443149000211 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 443149000212 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 443149000213 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 443149000214 dimer interface [polypeptide binding]; other site 443149000215 active site 443149000216 glycine-pyridoxal phosphate binding site [chemical binding]; other site 443149000217 folate binding site [chemical binding]; other site 443149000218 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 443149000219 active site 443149000220 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 443149000221 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443149000222 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443149000223 homodimer interface [polypeptide binding]; other site 443149000224 catalytic residue [active] 443149000225 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443149000226 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149000227 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149000228 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 443149000229 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443149000230 dimerization interface [polypeptide binding]; other site 443149000231 putative DNA binding site [nucleotide binding]; other site 443149000232 putative Zn2+ binding site [ion binding]; other site 443149000233 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 443149000234 hydrogenase 4 subunit B; Validated; Region: PRK06521 443149000235 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 443149000236 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 443149000237 NADH dehydrogenase; Region: NADHdh; cl00469 443149000238 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; COG4237 443149000239 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 443149000240 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 443149000241 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 443149000242 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 443149000243 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 443149000244 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 443149000245 putative hydrophobic ligand binding site [chemical binding]; other site 443149000246 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149000247 S-adenosylmethionine binding site [chemical binding]; other site 443149000248 Predicted membrane protein [Function unknown]; Region: COG3305 443149000249 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 443149000250 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 443149000251 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 443149000252 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 443149000253 metal-binding site [ion binding] 443149000254 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 443149000255 Soluble P-type ATPase [General function prediction only]; Region: COG4087 443149000256 Predicted integral membrane protein [Function unknown]; Region: COG5660 443149000257 Putative zinc-finger; Region: zf-HC2; pfam13490 443149000258 Domain of unknown function (DUF222); Region: DUF222; pfam02720 443149000259 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 443149000260 active site 443149000261 Domain of unknown function (DUF222); Region: DUF222; pfam02720 443149000262 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149000263 PPE family; Region: PPE; pfam00823 443149000264 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 443149000265 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 443149000266 FcoT-like thioesterase domain; Region: FcoT; pfam10862 443149000267 acyl-CoA synthetase; Validated; Region: PRK05857 443149000268 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443149000269 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 443149000270 acyl-activating enzyme (AAE) consensus motif; other site 443149000271 acyl-activating enzyme (AAE) consensus motif; other site 443149000272 AMP binding site [chemical binding]; other site 443149000273 active site 443149000274 CoA binding site [chemical binding]; other site 443149000275 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 443149000276 AMP-binding enzyme; Region: AMP-binding; pfam00501 443149000277 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443149000278 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443149000279 acyl-activating enzyme (AAE) consensus motif; other site 443149000280 acyl-activating enzyme (AAE) consensus motif; other site 443149000281 active site 443149000282 AMP binding site [chemical binding]; other site 443149000283 CoA binding site [chemical binding]; other site 443149000284 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 443149000285 Condensation domain; Region: Condensation; pfam00668 443149000286 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 443149000287 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 443149000288 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 443149000289 acyl-activating enzyme (AAE) consensus motif; other site 443149000290 AMP binding site [chemical binding]; other site 443149000291 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 443149000292 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 443149000293 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 443149000294 putative NAD(P) binding site [chemical binding]; other site 443149000295 active site 443149000296 putative substrate binding site [chemical binding]; other site 443149000297 Predicted membrane protein [Function unknown]; Region: COG3336 443149000298 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 443149000299 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 443149000300 metal-binding site [ion binding] 443149000301 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 443149000302 Soluble P-type ATPase [General function prediction only]; Region: COG4087 443149000303 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 443149000304 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 443149000305 ligand binding site [chemical binding]; other site 443149000306 flexible hinge region; other site 443149000307 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 443149000308 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 443149000309 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 443149000310 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 443149000311 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 443149000312 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 443149000313 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443149000314 motif II; other site 443149000315 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 443149000316 PE family; Region: PE; pfam00934 443149000317 Rhomboid family; Region: Rhomboid; pfam01694 443149000318 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 443149000319 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 443149000320 active site 443149000321 catalytic triad [active] 443149000322 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 443149000323 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 443149000324 NADP-binding site; other site 443149000325 homotetramer interface [polypeptide binding]; other site 443149000326 substrate binding site [chemical binding]; other site 443149000327 homodimer interface [polypeptide binding]; other site 443149000328 active site 443149000329 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 443149000330 dimer interface [polypeptide binding]; other site 443149000331 active site 443149000332 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 443149000333 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443149000334 active site 443149000335 motif I; other site 443149000336 motif II; other site 443149000337 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 443149000338 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 443149000339 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 443149000340 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 443149000341 Transcriptional regulator [Transcription]; Region: LysR; COG0583 443149000342 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 443149000343 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 443149000344 dimerization interface [polypeptide binding]; other site 443149000345 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 443149000346 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 443149000347 PYR/PP interface [polypeptide binding]; other site 443149000348 dimer interface [polypeptide binding]; other site 443149000349 TPP binding site [chemical binding]; other site 443149000350 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 443149000351 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 443149000352 TPP-binding site; other site 443149000353 dimer interface [polypeptide binding]; other site 443149000354 acyl-CoA synthetase; Validated; Region: PRK05852 443149000355 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443149000356 Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926 443149000357 acyl-activating enzyme (AAE) consensus motif; other site 443149000358 acyl-activating enzyme (AAE) consensus motif; other site 443149000359 putative AMP binding site [chemical binding]; other site 443149000360 putative active site [active] 443149000361 putative CoA binding site [chemical binding]; other site 443149000362 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 443149000363 elongation factor G; Reviewed; Region: PRK12740 443149000364 G1 box; other site 443149000365 putative GEF interaction site [polypeptide binding]; other site 443149000366 GTP/Mg2+ binding site [chemical binding]; other site 443149000367 Switch I region; other site 443149000368 G2 box; other site 443149000369 G3 box; other site 443149000370 Switch II region; other site 443149000371 G4 box; other site 443149000372 G5 box; other site 443149000373 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 443149000374 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 443149000375 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 443149000376 PPOX class probable F420-dependent enzyme, Rv0121 family; Region: Rv0121_F420; TIGR03668 443149000377 PE family; Region: PE; pfam00934 443149000378 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 443149000379 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 443149000380 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 443149000381 trehalose synthase; Region: treS_nterm; TIGR02456 443149000382 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 443149000383 active site 443149000384 catalytic site [active] 443149000385 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 443149000386 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 443149000387 Predicted membrane protein [Function unknown]; Region: COG3619 443149000388 Predicted esterase [General function prediction only]; Region: COG0627 443149000389 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 443149000390 putative active site [active] 443149000391 putative catalytic site [active] 443149000392 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149000393 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443149000394 active site 443149000395 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 443149000396 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 443149000397 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 443149000398 Coenzyme A binding pocket [chemical binding]; other site 443149000399 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 443149000400 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443149000401 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149000402 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149000403 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443149000404 Cytochrome P450; Region: p450; cl12078 443149000405 methionine sulfoxide reductase A; Provisional; Region: PRK14054 443149000406 SnoaL-like domain; Region: SnoaL_2; pfam12680 443149000407 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 443149000408 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443149000409 NAD(P) binding site [chemical binding]; other site 443149000410 active site 443149000411 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 443149000412 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 443149000413 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 443149000414 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 443149000415 minor groove reading motif; other site 443149000416 helix-hairpin-helix signature motif; other site 443149000417 active site 443149000418 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 443149000419 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 443149000420 Cl- selectivity filter; other site 443149000421 Cl- binding residues [ion binding]; other site 443149000422 pore gating glutamate residue; other site 443149000423 dimer interface [polypeptide binding]; other site 443149000424 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149000425 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149000426 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 443149000427 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 443149000428 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 443149000429 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 443149000430 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 443149000431 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 443149000432 NAD(P) binding site [chemical binding]; other site 443149000433 catalytic residues [active] 443149000434 short chain dehydrogenase; Provisional; Region: PRK07791 443149000435 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 443149000436 NAD binding site [chemical binding]; other site 443149000437 homodimer interface [polypeptide binding]; other site 443149000438 active site 443149000439 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 443149000440 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 443149000441 NAD(P) binding site [chemical binding]; other site 443149000442 PE family; Region: PE; pfam00934 443149000443 PE-PPE domain; Region: PE-PPE; pfam08237 443149000444 PE-PPE domain; Region: PE-PPE; pfam08237 443149000445 PE family; Region: PE; pfam00934 443149000446 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 443149000447 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 443149000448 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 443149000449 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149000450 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 443149000451 FAD binding site [chemical binding]; other site 443149000452 substrate binding site [chemical binding]; other site 443149000453 catalytic base [active] 443149000454 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 443149000455 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 443149000456 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 443149000457 ligand binding site [chemical binding]; other site 443149000458 homodimer interface [polypeptide binding]; other site 443149000459 NAD(P) binding site [chemical binding]; other site 443149000460 trimer interface B [polypeptide binding]; other site 443149000461 trimer interface A [polypeptide binding]; other site 443149000462 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 443149000463 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 443149000464 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 443149000465 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 443149000466 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149000467 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149000468 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 443149000469 PE family; Region: PE; pfam00934 443149000470 PE-PPE domain; Region: PE-PPE; pfam08237 443149000471 PE family; Region: PE; pfam00934 443149000472 PE-PPE domain; Region: PE-PPE; pfam08237 443149000473 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 443149000474 FAD binding domain; Region: FAD_binding_4; pfam01565 443149000475 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 443149000476 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 443149000477 NAD(P) binding site [chemical binding]; other site 443149000478 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 443149000479 active site 443149000480 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 443149000481 putative hydrophobic ligand binding site [chemical binding]; other site 443149000482 Transcriptional regulators [Transcription]; Region: GntR; COG1802 443149000483 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443149000484 DNA-binding site [nucleotide binding]; DNA binding site 443149000485 FCD domain; Region: FCD; pfam07729 443149000486 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786 443149000487 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443149000488 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 443149000489 acyl-activating enzyme (AAE) consensus motif; other site 443149000490 acyl-activating enzyme (AAE) consensus motif; other site 443149000491 putative AMP binding site [chemical binding]; other site 443149000492 putative active site [active] 443149000493 putative CoA binding site [chemical binding]; other site 443149000494 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 443149000495 Permease; Region: Permease; pfam02405 443149000496 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 443149000497 Permease; Region: Permease; pfam02405 443149000498 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443149000499 mce related protein; Region: MCE; pfam02470 443149000500 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 443149000501 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443149000502 mce related protein; Region: MCE; pfam02470 443149000503 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 443149000504 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443149000505 mce related protein; Region: MCE; pfam02470 443149000506 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443149000507 mce related protein; Region: MCE; pfam02470 443149000508 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443149000509 mce related protein; Region: MCE; pfam02470 443149000510 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443149000511 mce related protein; Region: MCE; pfam02470 443149000512 RDD family; Region: RDD; pfam06271 443149000513 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 443149000514 Predicted membrane protein [Function unknown]; Region: COG1511 443149000515 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 443149000516 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 443149000517 Pirin-related protein [General function prediction only]; Region: COG1741 443149000518 Pirin; Region: Pirin; pfam02678 443149000519 RNA polymerase factor sigma-70; Validated; Region: PRK08241 443149000520 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443149000521 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443149000522 DNA binding residues [nucleotide binding] 443149000523 SnoaL-like domain; Region: SnoaL_2; pfam12680 443149000524 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 443149000525 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 443149000526 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 443149000527 putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185 443149000528 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 443149000529 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 443149000530 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 443149000531 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 443149000532 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 443149000533 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149000534 S-adenosylmethionine binding site [chemical binding]; other site 443149000535 SPW repeat; Region: SPW; pfam03779 443149000536 SPW repeat; Region: SPW; pfam03779 443149000537 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 443149000538 6-phosphogluconate dehydratase; Region: edd; TIGR01196 443149000539 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 443149000540 putative homodimer interface [polypeptide binding]; other site 443149000541 putative homotetramer interface [polypeptide binding]; other site 443149000542 putative allosteric switch controlling residues; other site 443149000543 putative metal binding site [ion binding]; other site 443149000544 putative homodimer-homodimer interface [polypeptide binding]; other site 443149000545 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 443149000546 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443149000547 putative substrate translocation pore; other site 443149000548 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 443149000549 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 443149000550 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 443149000551 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 443149000552 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 443149000553 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443149000554 Walker A/P-loop; other site 443149000555 ATP binding site [chemical binding]; other site 443149000556 Q-loop/lid; other site 443149000557 ABC transporter signature motif; other site 443149000558 Walker B; other site 443149000559 D-loop; other site 443149000560 H-loop/switch region; other site 443149000561 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 443149000562 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443149000563 Walker A/P-loop; other site 443149000564 ATP binding site [chemical binding]; other site 443149000565 Q-loop/lid; other site 443149000566 ABC transporter signature motif; other site 443149000567 Walker B; other site 443149000568 D-loop; other site 443149000569 H-loop/switch region; other site 443149000570 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443149000571 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443149000572 dimerization interface [polypeptide binding]; other site 443149000573 DNA binding residues [nucleotide binding] 443149000574 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149000575 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149000576 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 443149000577 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 443149000578 putative [Fe4-S4] binding site [ion binding]; other site 443149000579 putative molybdopterin cofactor binding site [chemical binding]; other site 443149000580 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 443149000581 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 443149000582 putative molybdopterin cofactor binding site; other site 443149000583 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 443149000584 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 443149000585 active site 443149000586 Zn binding site [ion binding]; other site 443149000587 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 443149000588 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 443149000589 Predicted integral membrane protein [Function unknown]; Region: COG0392 443149000590 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 443149000591 Domain of unknown function DUF20; Region: UPF0118; pfam01594 443149000592 MMPL family; Region: MMPL; pfam03176 443149000593 MMPL family; Region: MMPL; pfam03176 443149000594 LabA_like proteins; Region: LabA_like; cd06167 443149000595 putative metal binding site [ion binding]; other site 443149000596 Putative methyltransferase; Region: Methyltransf_4; pfam02390 443149000597 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 443149000598 active site 443149000599 substrate-binding site [chemical binding]; other site 443149000600 metal-binding site [ion binding] 443149000601 GTP binding site [chemical binding]; other site 443149000602 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 443149000603 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 443149000604 active site 443149000605 (T/H)XGH motif; other site 443149000606 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 443149000607 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 443149000608 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 443149000609 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443149000610 FeS/SAM binding site; other site 443149000611 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 443149000612 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443149000613 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 443149000614 acyl-activating enzyme (AAE) consensus motif; other site 443149000615 acyl-activating enzyme (AAE) consensus motif; other site 443149000616 putative AMP binding site [chemical binding]; other site 443149000617 putative active site [active] 443149000618 putative CoA binding site [chemical binding]; other site 443149000619 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149000620 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443149000621 active site 443149000622 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 443149000623 putative active site [active] 443149000624 putative catalytic site [active] 443149000625 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 443149000626 active site 2 [active] 443149000627 active site 1 [active] 443149000628 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 443149000629 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 443149000630 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 443149000631 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321 443149000632 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 443149000633 Moco binding site; other site 443149000634 metal coordination site [ion binding]; other site 443149000635 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 443149000636 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 443149000637 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443149000638 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443149000639 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 443149000640 enoyl-CoA hydratase; Provisional; Region: PRK08252 443149000641 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443149000642 substrate binding site [chemical binding]; other site 443149000643 oxyanion hole (OAH) forming residues; other site 443149000644 trimer interface [polypeptide binding]; other site 443149000645 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 443149000646 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 443149000647 NAD binding site [chemical binding]; other site 443149000648 catalytic residues [active] 443149000649 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149000650 S-adenosylmethionine binding site [chemical binding]; other site 443149000651 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 443149000652 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443149000653 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 443149000654 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 443149000655 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 443149000656 putative active site [active] 443149000657 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 443149000658 active site 443149000659 substrate binding pocket [chemical binding]; other site 443149000660 homodimer interaction site [polypeptide binding]; other site 443149000661 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149000662 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 443149000663 active site 443149000664 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149000665 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149000666 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 443149000667 active site 443149000668 diiron metal binding site [ion binding]; other site 443149000669 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 443149000670 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 443149000671 NAD(P) binding site [chemical binding]; other site 443149000672 catalytic residues [active] 443149000673 Lipase maturation factor; Region: LMF1; pfam06762 443149000674 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 443149000675 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 443149000676 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 443149000677 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 443149000678 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149000679 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149000680 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 443149000681 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 443149000682 MaoC like domain; Region: MaoC_dehydratas; pfam01575 443149000683 active site 2 [active] 443149000684 active site 1 [active] 443149000685 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 443149000686 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443149000687 NAD(P) binding site [chemical binding]; other site 443149000688 active site 443149000689 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 443149000690 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 443149000691 dimer interface [polypeptide binding]; other site 443149000692 active site 443149000693 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 443149000694 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 443149000695 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 443149000696 FAD binding site [chemical binding]; other site 443149000697 substrate binding site [chemical binding]; other site 443149000698 catalytic residues [active] 443149000699 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 443149000700 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 443149000701 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 443149000702 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443149000703 catalytic loop [active] 443149000704 iron binding site [ion binding]; other site 443149000705 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 443149000706 L-aspartate oxidase; Provisional; Region: PRK06175 443149000707 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 443149000708 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 443149000709 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 443149000710 putative dimer interface [polypeptide binding]; other site 443149000711 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 443149000712 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443149000713 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 443149000714 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 443149000715 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 443149000716 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 443149000717 homotrimer interface [polypeptide binding]; other site 443149000718 Walker A motif; other site 443149000719 GTP binding site [chemical binding]; other site 443149000720 Walker B motif; other site 443149000721 cobyric acid synthase; Provisional; Region: PRK00784 443149000722 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 443149000723 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 443149000724 catalytic triad [active] 443149000725 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149000726 PPE family; Region: PPE; pfam00823 443149000727 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 443149000728 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 443149000729 putative active site [active] 443149000730 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 443149000731 putative active site [active] 443149000732 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 443149000733 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 443149000734 active site 443149000735 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 443149000736 DNA binding site [nucleotide binding] 443149000737 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 443149000738 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443149000739 Coenzyme A binding pocket [chemical binding]; other site 443149000740 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 443149000741 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 443149000742 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 443149000743 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 443149000744 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 443149000745 intersubunit interface [polypeptide binding]; other site 443149000746 5-oxoprolinase; Region: PLN02666 443149000747 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 443149000748 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 443149000749 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 443149000750 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 443149000751 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 443149000752 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 443149000753 nucleotide binding site [chemical binding]; other site 443149000754 acyl-CoA synthetase; Validated; Region: PRK07788 443149000755 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443149000756 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443149000757 active site 443149000758 CoA binding site [chemical binding]; other site 443149000759 AMP binding site [chemical binding]; other site 443149000760 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149000761 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443149000762 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 443149000763 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149000764 FAD binding site [chemical binding]; other site 443149000765 substrate binding site [chemical binding]; other site 443149000766 catalytic base [active] 443149000767 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443149000768 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149000769 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149000770 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 443149000771 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443149000772 Zn binding site [ion binding]; other site 443149000773 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 443149000774 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 443149000775 putative active site [active] 443149000776 PE family; Region: PE; pfam00934 443149000777 PE family; Region: PE; pfam00934 443149000778 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149000779 PPE family; Region: PPE; pfam00823 443149000780 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149000781 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 443149000782 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 443149000783 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 443149000784 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443149000785 Walker A motif; other site 443149000786 ATP binding site [chemical binding]; other site 443149000787 Walker B motif; other site 443149000788 arginine finger; other site 443149000789 Protein of unknown function (DUF690); Region: DUF690; pfam05108 443149000790 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 443149000791 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 443149000792 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 443149000793 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 443149000794 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 443149000795 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149000796 PPE family; Region: PPE; pfam00823 443149000797 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 443149000798 EspG family; Region: ESX-1_EspG; pfam14011 443149000799 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 443149000800 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 443149000801 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 443149000802 active site 443149000803 catalytic residues [active] 443149000804 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 443149000805 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443149000806 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 443149000807 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 443149000808 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149000809 S-adenosylmethionine binding site [chemical binding]; other site 443149000810 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4424 443149000811 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 443149000812 Sulfatase; Region: Sulfatase; cl17466 443149000813 hypothetical protein; Region: PHA01748 443149000814 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 443149000815 putative active site [active] 443149000816 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149000817 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149000818 light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs; Region: LPOR_like_SDR_c_like; cd09810 443149000819 protochlorophyllide reductase; Region: PLN00015 443149000820 putative NAD(P) binding site [chemical binding]; other site 443149000821 active site 443149000822 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149000823 PPE family; Region: PPE; pfam00823 443149000824 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149000825 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149000826 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149000827 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149000828 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149000829 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149000830 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149000831 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149000832 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149000833 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149000834 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149000835 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149000836 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 443149000837 putative FMN binding site [chemical binding]; other site 443149000838 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 443149000839 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 443149000840 active site 443149000841 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 443149000842 SnoaL-like domain; Region: SnoaL_4; pfam13577 443149000843 SnoaL-like domain; Region: SnoaL_3; pfam13474 443149000844 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 443149000845 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 443149000846 nucleotide binding site [chemical binding]; other site 443149000847 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]; Region: HtpG; COG0326 443149000848 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 443149000849 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 443149000850 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 443149000851 active site 443149000852 catalytic residues [active] 443149000853 Muconolactone delta-isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CatC1; COG4829 443149000854 Muconolactone delta-isomerase; Region: MIase; cl01992 443149000855 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 443149000856 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 443149000857 putative active site [active] 443149000858 catalytic site [active] 443149000859 putative metal binding site [ion binding]; other site 443149000860 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 443149000861 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 443149000862 putative substrate binding pocket [chemical binding]; other site 443149000863 AC domain interface; other site 443149000864 catalytic triad [active] 443149000865 AB domain interface; other site 443149000866 interchain disulfide; other site 443149000867 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 443149000868 trimer interface [polypeptide binding]; other site 443149000869 active site 443149000870 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 443149000871 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 443149000872 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 443149000873 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 443149000874 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 443149000875 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443149000876 dimerization interface [polypeptide binding]; other site 443149000877 putative DNA binding site [nucleotide binding]; other site 443149000878 putative Zn2+ binding site [ion binding]; other site 443149000879 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 443149000880 active site residue [active] 443149000881 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149000882 S-adenosylmethionine binding site [chemical binding]; other site 443149000883 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443149000884 Cytochrome P450; Region: p450; cl12078 443149000885 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 443149000886 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149000887 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 443149000888 Methyltransferase domain; Region: Methyltransf_23; pfam13489 443149000889 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149000890 S-adenosylmethionine binding site [chemical binding]; other site 443149000891 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149000892 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149000893 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 443149000894 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 443149000895 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 443149000896 SnoaL-like domain; Region: SnoaL_2; pfam12680 443149000897 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 443149000898 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 443149000899 substrate binding site; other site 443149000900 tetramer interface; other site 443149000901 PE family; Region: PE; pfam00934 443149000902 Domain of unknown function (DUF222); Region: DUF222; pfam02720 443149000903 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 443149000904 active site 443149000905 aminotransferase AlaT; Validated; Region: PRK09265 443149000906 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443149000907 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443149000908 homodimer interface [polypeptide binding]; other site 443149000909 catalytic residue [active] 443149000910 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 443149000911 4Fe-4S binding domain; Region: Fer4; pfam00037 443149000912 Cysteine-rich domain; Region: CCG; pfam02754 443149000913 Cysteine-rich domain; Region: CCG; pfam02754 443149000914 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443149000915 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443149000916 DNA binding residues [nucleotide binding] 443149000917 dimerization interface [polypeptide binding]; other site 443149000918 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 443149000919 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 443149000920 G1 box; other site 443149000921 GTP/Mg2+ binding site [chemical binding]; other site 443149000922 G2 box; other site 443149000923 Switch I region; other site 443149000924 G3 box; other site 443149000925 Switch II region; other site 443149000926 G4 box; other site 443149000927 G5 box; other site 443149000928 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 443149000929 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 443149000930 G1 box; other site 443149000931 GTP/Mg2+ binding site [chemical binding]; other site 443149000932 G2 box; other site 443149000933 Switch I region; other site 443149000934 G3 box; other site 443149000935 Switch II region; other site 443149000936 Uncharacterized MobA-related protein [General function prediction only]; Region: COG2068 443149000937 active site 443149000938 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 443149000939 TIGR04255 family protein; Region: sporadTIGR04255 443149000940 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 443149000941 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 443149000942 nucleotide binding site [chemical binding]; other site 443149000943 NEF interaction site [polypeptide binding]; other site 443149000944 SBD interface [polypeptide binding]; other site 443149000945 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 443149000946 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 443149000947 dimer interface [polypeptide binding]; other site 443149000948 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 443149000949 chaperone protein DnaJ; Provisional; Region: PRK14279 443149000950 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 443149000951 HSP70 interaction site [polypeptide binding]; other site 443149000952 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 443149000953 Zn binding sites [ion binding]; other site 443149000954 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 443149000955 dimer interface [polypeptide binding]; other site 443149000956 Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279 443149000957 DNA binding residues [nucleotide binding] 443149000958 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 443149000959 putative dimer interface [polypeptide binding]; other site 443149000960 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149000961 PPE family; Region: PPE; pfam00823 443149000962 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149000963 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149000964 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149000965 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149000966 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149000967 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 443149000968 CoenzymeA binding site [chemical binding]; other site 443149000969 subunit interaction site [polypeptide binding]; other site 443149000970 PHB binding site; other site 443149000971 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 443149000972 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 443149000973 GDP-binding site [chemical binding]; other site 443149000974 ACT binding site; other site 443149000975 IMP binding site; other site 443149000976 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 443149000977 Peptidase family M50; Region: Peptidase_M50; pfam02163 443149000978 active site 443149000979 putative substrate binding region [chemical binding]; other site 443149000980 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 443149000981 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 443149000982 MgtE intracellular N domain; Region: MgtE_N; pfam03448 443149000983 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 443149000984 Divalent cation transporter; Region: MgtE; pfam01769 443149000985 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 443149000986 fructose-bisphosphate aldolase, class II, yeast/E. coli subtype; Region: FruBisAldo_II_A; TIGR01520 443149000987 active site 443149000988 intersubunit interface [polypeptide binding]; other site 443149000989 zinc binding site [ion binding]; other site 443149000990 Na+ binding site [ion binding]; other site 443149000991 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 443149000992 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 443149000993 Predicted glycosyl hydrolase [Carbohydrate transport and metabolism]; Region: COG4833 443149000994 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 443149000995 AAA domain; Region: AAA_33; pfam13671 443149000996 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 443149000997 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 443149000998 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 443149000999 putative hydrophobic ligand binding site [chemical binding]; other site 443149001000 MoxR-like ATPases [General function prediction only]; Region: COG0714 443149001001 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 443149001002 Ligand binding site; other site 443149001003 metal-binding site 443149001004 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 443149001005 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 443149001006 XdhC Rossmann domain; Region: XdhC_C; pfam13478 443149001007 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 443149001008 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 443149001009 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 443149001010 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 443149001011 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443149001012 catalytic loop [active] 443149001013 iron binding site [ion binding]; other site 443149001014 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 443149001015 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 443149001016 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 443149001017 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 443149001018 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 443149001019 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 443149001020 XdhC Rossmann domain; Region: XdhC_C; pfam13478 443149001021 Transcriptional regulator [Transcription]; Region: LysR; COG0583 443149001022 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 443149001023 LysR substrate binding domain; Region: LysR_substrate; pfam03466 443149001024 dimerization interface [polypeptide binding]; other site 443149001025 Uncharacterized conserved protein [Function unknown]; Region: COG3360 443149001026 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 443149001027 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 443149001028 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 443149001029 active site 443149001030 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 443149001031 Clp amino terminal domain; Region: Clp_N; pfam02861 443149001032 Clp amino terminal domain; Region: Clp_N; pfam02861 443149001033 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443149001034 Walker A motif; other site 443149001035 ATP binding site [chemical binding]; other site 443149001036 Walker B motif; other site 443149001037 arginine finger; other site 443149001038 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443149001039 Walker A motif; other site 443149001040 ATP binding site [chemical binding]; other site 443149001041 Walker B motif; other site 443149001042 arginine finger; other site 443149001043 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 443149001044 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 443149001045 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 443149001046 heme-binding site [chemical binding]; other site 443149001047 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 443149001048 FAD binding pocket [chemical binding]; other site 443149001049 FAD binding motif [chemical binding]; other site 443149001050 phosphate binding motif [ion binding]; other site 443149001051 beta-alpha-beta structure motif; other site 443149001052 NAD binding pocket [chemical binding]; other site 443149001053 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 443149001054 cyclase homology domain; Region: CHD; cd07302 443149001055 nucleotidyl binding site; other site 443149001056 metal binding site [ion binding]; metal-binding site 443149001057 dimer interface [polypeptide binding]; other site 443149001058 Predicted ATPase [General function prediction only]; Region: COG3903 443149001059 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 443149001060 Walker A motif; other site 443149001061 ATP binding site [chemical binding]; other site 443149001062 Walker B motif; other site 443149001063 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443149001064 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443149001065 DNA binding residues [nucleotide binding] 443149001066 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149001067 PPE family; Region: PPE; pfam00823 443149001068 Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase) [Nucleotide transport and metabolism]; Region: PurT; COG0027 443149001069 ATP-grasp domain; Region: ATP-grasp_4; cl17255 443149001070 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 443149001071 active site residue [active] 443149001072 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 443149001073 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 443149001074 homodimer interface [polypeptide binding]; other site 443149001075 substrate-cofactor binding pocket; other site 443149001076 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443149001077 catalytic residue [active] 443149001078 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 443149001079 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 443149001080 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443149001081 Domain of unknown function (DUF222); Region: DUF222; pfam02720 443149001082 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 443149001083 active site 443149001084 PLD-like domain; Region: PLDc_2; pfam13091 443149001085 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 443149001086 Beta-lactamase; Region: Beta-lactamase; pfam00144 443149001087 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 443149001088 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149001089 FAD binding site [chemical binding]; other site 443149001090 substrate binding pocket [chemical binding]; other site 443149001091 catalytic base [active] 443149001092 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 443149001093 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 443149001094 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 443149001095 acyl-CoA synthetase; Validated; Region: PRK05850 443149001096 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 443149001097 acyl-activating enzyme (AAE) consensus motif; other site 443149001098 active site 443149001099 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 443149001100 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 443149001101 active site 443149001102 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 443149001103 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 443149001104 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 443149001105 Thioesterase; Region: PKS_TE; smart00824 443149001106 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 443149001107 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 443149001108 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 443149001109 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 443149001110 phosphate acetyltransferase; Reviewed; Region: PRK05632 443149001111 DRTGG domain; Region: DRTGG; pfam07085 443149001112 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 443149001113 propionate/acetate kinase; Provisional; Region: PRK12379 443149001114 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 443149001115 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 443149001116 Catalytic domain of Protein Kinases; Region: PKc; cd00180 443149001117 active site 443149001118 ATP binding site [chemical binding]; other site 443149001119 substrate binding site [chemical binding]; other site 443149001120 activation loop (A-loop); other site 443149001121 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 443149001122 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 443149001123 substrate binding pocket [chemical binding]; other site 443149001124 membrane-bound complex binding site; other site 443149001125 hinge residues; other site 443149001126 NUDIX domain; Region: NUDIX; pfam00293 443149001127 nudix motif; other site 443149001128 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 443149001129 thiamine phosphate binding site [chemical binding]; other site 443149001130 active site 443149001131 pyrophosphate binding site [ion binding]; other site 443149001132 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 443149001133 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 443149001134 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 443149001135 thiS-thiF/thiG interaction site; other site 443149001136 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 443149001137 ThiS interaction site; other site 443149001138 putative active site [active] 443149001139 tetramer interface [polypeptide binding]; other site 443149001140 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 443149001141 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 443149001142 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 443149001143 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 443149001144 PA/protease or protease-like domain interface [polypeptide binding]; other site 443149001145 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 443149001146 active site 443149001147 metal binding site [ion binding]; metal-binding site 443149001148 Predicted metalloprotease [General function prediction only]; Region: COG2321 443149001149 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 443149001150 Zn binding site [ion binding]; other site 443149001151 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 443149001152 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 443149001153 dimer interface [polypeptide binding]; other site 443149001154 substrate binding site [chemical binding]; other site 443149001155 ATP binding site [chemical binding]; other site 443149001156 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 443149001157 ThiC-associated domain; Region: ThiC-associated; pfam13667 443149001158 ThiC family; Region: ThiC; pfam01964 443149001159 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 443149001160 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 443149001161 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443149001162 motif II; other site 443149001163 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 443149001164 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 443149001165 putative catalytic site [active] 443149001166 putative phosphate binding site [ion binding]; other site 443149001167 active site 443149001168 metal binding site A [ion binding]; metal-binding site 443149001169 DNA binding site [nucleotide binding] 443149001170 putative AP binding site [nucleotide binding]; other site 443149001171 putative metal binding site B [ion binding]; other site 443149001172 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 443149001173 active site 443149001174 catalytic residues [active] 443149001175 metal binding site [ion binding]; metal-binding site 443149001176 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 443149001177 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 443149001178 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 443149001179 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 443149001180 E-class dimer interface [polypeptide binding]; other site 443149001181 P-class dimer interface [polypeptide binding]; other site 443149001182 active site 443149001183 Cu2+ binding site [ion binding]; other site 443149001184 Zn2+ binding site [ion binding]; other site 443149001185 carboxylate-amine ligase; Provisional; Region: PRK13517 443149001186 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 443149001187 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 443149001188 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 443149001189 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 443149001190 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443149001191 Walker A motif; other site 443149001192 ATP binding site [chemical binding]; other site 443149001193 Walker B motif; other site 443149001194 arginine finger; other site 443149001195 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443149001196 Walker A motif; other site 443149001197 ATP binding site [chemical binding]; other site 443149001198 Walker B motif; other site 443149001199 arginine finger; other site 443149001200 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 443149001201 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 443149001202 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 443149001203 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 443149001204 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 443149001205 dimer interface [polypeptide binding]; other site 443149001206 putative functional site; other site 443149001207 putative MPT binding site; other site 443149001208 short chain dehydrogenase; Provisional; Region: PRK06197 443149001209 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 443149001210 putative NAD(P) binding site [chemical binding]; other site 443149001211 active site 443149001212 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 443149001213 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 443149001214 ring oligomerisation interface [polypeptide binding]; other site 443149001215 ATP/Mg binding site [chemical binding]; other site 443149001216 stacking interactions; other site 443149001217 hinge regions; other site 443149001218 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149001219 PPE family; Region: PPE; pfam00823 443149001220 Protein of unknown function (DUF664); Region: DUF664; pfam04978 443149001221 DinB superfamily; Region: DinB_2; pfam12867 443149001222 putative anti-sigmaE protein; Provisional; Region: PRK13920 443149001223 Anti-sigma-K factor rskA; Region: RskA; pfam10099 443149001224 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 443149001225 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443149001226 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443149001227 DNA binding residues [nucleotide binding] 443149001228 Steroid 5-alpha reductase family enzyme [General function prediction only]; Region: COG3752 443149001229 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 443149001230 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149001231 S-adenosylmethionine binding site [chemical binding]; other site 443149001232 Uncharacterized conserved protein [Function unknown]; Region: COG3496 443149001233 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 443149001234 Subunit A of Class III extradiol dioxygenases; Region: Extradiol_Dioxygenase_3A_like; cl06673 443149001235 dimer interface [polypeptide binding]; other site 443149001236 Transport protein; Region: actII; TIGR00833 443149001237 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 443149001238 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149001239 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149001240 PPE family; Region: PPE; pfam00823 443149001241 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149001242 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 443149001243 enoyl-CoA hydratase; Provisional; Region: PRK12478 443149001244 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443149001245 substrate binding site [chemical binding]; other site 443149001246 oxyanion hole (OAH) forming residues; other site 443149001247 trimer interface [polypeptide binding]; other site 443149001248 PemK-like protein; Region: PemK; pfam02452 443149001249 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 443149001250 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 443149001251 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 443149001252 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 443149001253 NAD(P) binding site [chemical binding]; other site 443149001254 catalytic residues [active] 443149001255 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3564 443149001256 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 443149001257 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 443149001258 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443149001259 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 443149001260 Uncharacterized conserved protein [Function unknown]; Region: COG2128 443149001261 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 443149001262 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 443149001263 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443149001264 non-specific DNA binding site [nucleotide binding]; other site 443149001265 salt bridge; other site 443149001266 sequence-specific DNA binding site [nucleotide binding]; other site 443149001267 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 443149001268 Domain of unknown function (DUF955); Region: DUF955; pfam06114 443149001269 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 443149001270 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 443149001271 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 443149001272 active site 443149001273 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 443149001274 active site 2 [active] 443149001275 isocitrate lyase; Provisional; Region: PRK15063 443149001276 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cd06556 443149001277 oligomerization interface [polypeptide binding]; other site 443149001278 active site 443149001279 metal binding site [ion binding]; metal-binding site 443149001280 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 443149001281 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 443149001282 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 443149001283 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 443149001284 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149001285 S-adenosylmethionine binding site [chemical binding]; other site 443149001286 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 443149001287 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 443149001288 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149001289 S-adenosylmethionine binding site [chemical binding]; other site 443149001290 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 443149001291 UbiA prenyltransferase family; Region: UbiA; pfam01040 443149001292 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149001293 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149001294 Predicted membrane protein [Function unknown]; Region: COG2733 443149001295 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 443149001296 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443149001297 non-specific DNA binding site [nucleotide binding]; other site 443149001298 salt bridge; other site 443149001299 sequence-specific DNA binding site [nucleotide binding]; other site 443149001300 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 443149001301 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 443149001302 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 443149001303 intersubunit interface [polypeptide binding]; other site 443149001304 active site 443149001305 catalytic residue [active] 443149001306 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 443149001307 Predicted amidohydrolase [General function prediction only]; Region: COG0388 443149001308 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 443149001309 putative active site [active] 443149001310 catalytic triad [active] 443149001311 putative dimer interface [polypeptide binding]; other site 443149001312 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 443149001313 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 443149001314 FAD binding domain; Region: FAD_binding_4; pfam01565 443149001315 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 443149001316 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 443149001317 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 443149001318 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 443149001319 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 443149001320 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 443149001321 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443149001322 NAD(P) binding site [chemical binding]; other site 443149001323 active site 443149001324 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 443149001325 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 443149001326 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 443149001327 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 443149001328 putative ADP-binding pocket [chemical binding]; other site 443149001329 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 443149001330 L-lysine exporter; Region: 2a75; TIGR00948 443149001331 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 443149001332 catalytic core [active] 443149001333 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 443149001334 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443149001335 dimer interface [polypeptide binding]; other site 443149001336 phosphorylation site [posttranslational modification] 443149001337 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443149001338 ATP binding site [chemical binding]; other site 443149001339 Mg2+ binding site [ion binding]; other site 443149001340 G-X-G motif; other site 443149001341 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 443149001342 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443149001343 active site 443149001344 phosphorylation site [posttranslational modification] 443149001345 intermolecular recognition site; other site 443149001346 dimerization interface [polypeptide binding]; other site 443149001347 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443149001348 DNA binding site [nucleotide binding] 443149001349 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 443149001350 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 443149001351 Transcriptional regulators [Transcription]; Region: FadR; COG2186 443149001352 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443149001353 DNA-binding site [nucleotide binding]; DNA binding site 443149001354 FCD domain; Region: FCD; pfam07729 443149001355 exopolyphosphatase; Region: exo_poly_only; TIGR03706 443149001356 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 443149001357 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 443149001358 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 443149001359 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 443149001360 Diacylglycerol kinase catalytic domain (presumed); Region: DAGKc; smart00046 443149001361 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 443149001362 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 443149001363 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 443149001364 DNA binding domain, excisionase family; Region: excise; TIGR01764 443149001365 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 443149001366 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 443149001367 putative NAD(P) binding site [chemical binding]; other site 443149001368 active site 443149001369 putative substrate binding site [chemical binding]; other site 443149001370 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 443149001371 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 443149001372 putative acyl-acceptor binding pocket; other site 443149001373 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 443149001374 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 443149001375 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149001376 S-adenosylmethionine binding site [chemical binding]; other site 443149001377 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 443149001378 active site 443149001379 catalytic site [active] 443149001380 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 443149001381 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 443149001382 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 443149001383 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 443149001384 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 443149001385 glutamyl-tRNA reductase; Region: hemA; TIGR01035 443149001386 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 443149001387 tRNA; other site 443149001388 putative tRNA binding site [nucleotide binding]; other site 443149001389 putative NADP binding site [chemical binding]; other site 443149001390 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 443149001391 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 443149001392 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 443149001393 domain interfaces; other site 443149001394 active site 443149001395 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 443149001396 active site 443149001397 homodimer interface [polypeptide binding]; other site 443149001398 SAM binding site [chemical binding]; other site 443149001399 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 443149001400 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 443149001401 active site 443149001402 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 443149001403 dimer interface [polypeptide binding]; other site 443149001404 active site 443149001405 Schiff base residues; other site 443149001406 Domain of unknown function (DUF222); Region: DUF222; pfam02720 443149001407 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 443149001408 active site 443149001409 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 443149001410 anti sigma factor interaction site; other site 443149001411 regulatory phosphorylation site [posttranslational modification]; other site 443149001412 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 443149001413 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 443149001414 active site 443149001415 catalytic triad [active] 443149001416 oxyanion hole [active] 443149001417 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 443149001418 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149001419 Methyltransferase domain; Region: Methyltransf_31; pfam13847 443149001420 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 443149001421 Domain of unknown function (DUF385); Region: DUF385; pfam04075 443149001422 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 443149001423 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 443149001424 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443149001425 catalytic residue [active] 443149001426 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 443149001427 catalytic core [active] 443149001428 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 443149001429 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 443149001430 catalytic residues [active] 443149001431 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 443149001432 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 443149001433 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 443149001434 ResB-like family; Region: ResB; pfam05140 443149001435 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 443149001436 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 443149001437 AAA domain; Region: AAA_31; pfam13614 443149001438 P-loop; other site 443149001439 Magnesium ion binding site [ion binding]; other site 443149001440 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 443149001441 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 443149001442 3-oxoacyl-(acyl-carrier-protein) synthase III; Region: fabH; TIGR00747 443149001443 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 443149001444 dimer interface [polypeptide binding]; other site 443149001445 active site 443149001446 CoA binding pocket [chemical binding]; other site 443149001447 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 443149001448 UbiA prenyltransferase family; Region: UbiA; pfam01040 443149001449 5'-methylthioadenosine phosphorylase; Validated; Region: PRK07823 443149001450 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 443149001451 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443149001452 NAD(P) binding site [chemical binding]; other site 443149001453 active site 443149001454 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 443149001455 Ligand binding site; other site 443149001456 Putative Catalytic site; other site 443149001457 DXD motif; other site 443149001458 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3222 443149001459 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 443149001460 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443149001461 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443149001462 acyl-activating enzyme (AAE) consensus motif; other site 443149001463 acyl-activating enzyme (AAE) consensus motif; other site 443149001464 AMP binding site [chemical binding]; other site 443149001465 active site 443149001466 CoA binding site [chemical binding]; other site 443149001467 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 443149001468 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 443149001469 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443149001470 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 443149001471 active site 443149001472 short chain dehydrogenase; Provisional; Region: PRK05866 443149001473 classical (c) SDRs; Region: SDR_c; cd05233 443149001474 NAD(P) binding site [chemical binding]; other site 443149001475 active site 443149001476 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443149001477 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 443149001478 substrate binding site [chemical binding]; other site 443149001479 oxyanion hole (OAH) forming residues; other site 443149001480 trimer interface [polypeptide binding]; other site 443149001481 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 443149001482 putative active site [active] 443149001483 homotetrameric interface [polypeptide binding]; other site 443149001484 metal binding site [ion binding]; metal-binding site 443149001485 Post-segregation antitoxin (ccd killing mechanism protein) encoded by the F plasmid [General function prediction only]; Region: COG5302 443149001486 acyl-CoA synthetase; Validated; Region: PRK06188 443149001487 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 443149001488 putative active site [active] 443149001489 putative CoA binding site [chemical binding]; other site 443149001490 putative AMP binding site [chemical binding]; other site 443149001491 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 443149001492 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 443149001493 active site 443149001494 O-succinylbenzoate synthase; Provisional; Region: PRK02901 443149001495 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 443149001496 active site 443149001497 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443149001498 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 443149001499 TAP-like protein; Region: Abhydrolase_4; pfam08386 443149001500 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 443149001501 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 443149001502 dimer interface [polypeptide binding]; other site 443149001503 tetramer interface [polypeptide binding]; other site 443149001504 PYR/PP interface [polypeptide binding]; other site 443149001505 TPP binding site [chemical binding]; other site 443149001506 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 443149001507 TPP-binding site; other site 443149001508 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 443149001509 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443149001510 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 443149001511 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 443149001512 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149001513 S-adenosylmethionine binding site [chemical binding]; other site 443149001514 Protein of unknown function (DUF732); Region: DUF732; pfam05305 443149001515 Methyltransferase domain; Region: Methyltransf_23; pfam13489 443149001516 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149001517 S-adenosylmethionine binding site [chemical binding]; other site 443149001518 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 443149001519 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 443149001520 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 443149001521 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 443149001522 substrate binding pocket [chemical binding]; other site 443149001523 chain length determination region; other site 443149001524 substrate-Mg2+ binding site; other site 443149001525 catalytic residues [active] 443149001526 aspartate-rich region 1; other site 443149001527 active site lid residues [active] 443149001528 aspartate-rich region 2; other site 443149001529 heat shock protein HtpX; Provisional; Region: PRK03072 443149001530 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439 443149001531 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 443149001532 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 443149001533 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 443149001534 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 443149001535 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 443149001536 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 443149001537 O-methyltransferase; Region: Methyltransf_2; pfam00891 443149001538 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443149001539 Cytochrome P450; Region: p450; cl12078 443149001540 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 443149001541 ATP cone domain; Region: ATP-cone; pfam03477 443149001542 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 443149001543 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 443149001544 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 443149001545 active site 443149001546 dimer interface [polypeptide binding]; other site 443149001547 effector binding site; other site 443149001548 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 443149001549 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 443149001550 active site 443149001551 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 443149001552 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 443149001553 nicotinate phosphoribosyltransferase; Provisional; Region: PRK12484 443149001554 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 443149001555 active site 443149001556 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 443149001557 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 443149001558 putative active site [active] 443149001559 putative metal binding site [ion binding]; other site 443149001560 hypothetical protein; Provisional; Region: PRK07588 443149001561 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 443149001562 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443149001563 dimerization interface [polypeptide binding]; other site 443149001564 putative DNA binding site [nucleotide binding]; other site 443149001565 putative Zn2+ binding site [ion binding]; other site 443149001566 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 443149001567 putative hydrophobic ligand binding site [chemical binding]; other site 443149001568 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 443149001569 TIGR03086 family protein; Region: TIGR03086 443149001570 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 443149001571 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443149001572 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 443149001573 PE family; Region: PE; pfam00934 443149001574 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451 443149001575 Uncharacterized conserved protein [Function unknown]; Region: COG1656 443149001576 Protein of unknown function DUF82; Region: DUF82; pfam01927 443149001577 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 443149001578 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 443149001579 putative active site [active] 443149001580 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 443149001581 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 443149001582 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 443149001583 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 443149001584 Transcriptional regulators [Transcription]; Region: FadR; COG2186 443149001585 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443149001586 DNA-binding site [nucleotide binding]; DNA binding site 443149001587 FCD domain; Region: FCD; pfam07729 443149001588 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 443149001589 Permease; Region: Permease; pfam02405 443149001590 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 443149001591 Permease; Region: Permease; pfam02405 443149001592 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443149001593 mce related protein; Region: MCE; pfam02470 443149001594 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 443149001595 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 443149001596 mce related protein; Region: MCE; pfam02470 443149001597 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 443149001598 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443149001599 mce related protein; Region: MCE; pfam02470 443149001600 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443149001601 mce related protein; Region: MCE; pfam02470 443149001602 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 443149001603 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443149001604 mce related protein; Region: MCE; pfam02470 443149001605 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443149001606 mce related protein; Region: MCE; pfam02470 443149001607 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 443149001608 oligomeric interface; other site 443149001609 putative active site [active] 443149001610 homodimer interface [polypeptide binding]; other site 443149001611 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 443149001612 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 443149001613 AAA domain; Region: AAA_14; pfam13173 443149001614 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 443149001615 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 443149001616 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443149001617 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443149001618 ATP binding site [chemical binding]; other site 443149001619 Mg2+ binding site [ion binding]; other site 443149001620 G-X-G motif; other site 443149001621 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443149001622 dimerization interface [polypeptide binding]; other site 443149001623 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 443149001624 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443149001625 active site 443149001626 phosphorylation site [posttranslational modification] 443149001627 intermolecular recognition site; other site 443149001628 dimerization interface [polypeptide binding]; other site 443149001629 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443149001630 DNA binding site [nucleotide binding] 443149001631 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 443149001632 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 443149001633 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 443149001634 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 443149001635 catalytic residues [active] 443149001636 catalytic nucleophile [active] 443149001637 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 443149001638 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 443149001639 Probable transposase; Region: OrfB_IS605; pfam01385 443149001640 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 443149001641 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 443149001642 putative active site [active] 443149001643 SEC-C motif; Region: SEC-C; pfam02810 443149001644 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB-like; cd09875 443149001645 putative active site [active] 443149001646 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 443149001647 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 443149001648 nucleotide binding site/active site [active] 443149001649 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 443149001650 galactokinase; Provisional; Region: PRK00555 443149001651 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 443149001652 Protein of unknown function (DUF732); Region: DUF732; pfam05305 443149001653 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 443149001654 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 443149001655 putative active site [active] 443149001656 Uncharacterized conserved protein [Function unknown]; Region: COG0398 443149001657 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 443149001658 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 443149001659 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 443149001660 oligomeric interface; other site 443149001661 putative active site [active] 443149001662 homodimer interface [polypeptide binding]; other site 443149001663 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 443149001664 FIST N domain; Region: FIST; pfam08495 443149001665 FIST C domain; Region: FIST_C; pfam10442 443149001666 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 443149001667 AAA domain; Region: AAA_30; pfam13604 443149001668 Family description; Region: UvrD_C_2; pfam13538 443149001669 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 443149001670 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 443149001671 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 443149001672 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 443149001673 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 443149001674 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443149001675 substrate binding site [chemical binding]; other site 443149001676 oxyanion hole (OAH) forming residues; other site 443149001677 trimer interface [polypeptide binding]; other site 443149001678 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 443149001679 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 443149001680 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 443149001681 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 443149001682 active site 443149001683 catalytic site [active] 443149001684 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 443149001685 active site 443149001686 catalytic site [active] 443149001687 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 443149001688 active site 443149001689 catalytic site [active] 443149001690 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 443149001691 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 443149001692 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 443149001693 putative homodimer interface [polypeptide binding]; other site 443149001694 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 443149001695 heterodimer interface [polypeptide binding]; other site 443149001696 homodimer interface [polypeptide binding]; other site 443149001697 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 443149001698 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 443149001699 23S rRNA interface [nucleotide binding]; other site 443149001700 L7/L12 interface [polypeptide binding]; other site 443149001701 putative thiostrepton binding site; other site 443149001702 L25 interface [polypeptide binding]; other site 443149001703 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 443149001704 mRNA/rRNA interface [nucleotide binding]; other site 443149001705 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 443149001706 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149001707 S-adenosylmethionine binding site [chemical binding]; other site 443149001708 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 443149001709 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 443149001710 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149001711 S-adenosylmethionine binding site [chemical binding]; other site 443149001712 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 443149001713 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 443149001714 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149001715 S-adenosylmethionine binding site [chemical binding]; other site 443149001716 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 443149001717 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 443149001718 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149001719 S-adenosylmethionine binding site [chemical binding]; other site 443149001720 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443149001721 TAP-like protein; Region: Abhydrolase_4; pfam08386 443149001722 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 443149001723 ABC1 family; Region: ABC1; cl17513 443149001724 N-terminal catalytic domain of class II alpha-mannosidases and similar proteins; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_like; cd10786 443149001725 active site 443149001726 catalytic site [active] 443149001727 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 443149001728 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 443149001729 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 443149001730 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 443149001731 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 443149001732 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 443149001733 23S rRNA interface [nucleotide binding]; other site 443149001734 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 443149001735 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 443149001736 core dimer interface [polypeptide binding]; other site 443149001737 peripheral dimer interface [polypeptide binding]; other site 443149001738 L10 interface [polypeptide binding]; other site 443149001739 L11 interface [polypeptide binding]; other site 443149001740 putative EF-Tu interaction site [polypeptide binding]; other site 443149001741 putative EF-G interaction site [polypeptide binding]; other site 443149001742 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149001743 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149001744 WHG domain; Region: WHG; pfam13305 443149001745 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 443149001746 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 443149001747 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 443149001748 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 443149001749 Walker A/P-loop; other site 443149001750 ATP binding site [chemical binding]; other site 443149001751 Q-loop/lid; other site 443149001752 ABC transporter signature motif; other site 443149001753 Walker B; other site 443149001754 D-loop; other site 443149001755 H-loop/switch region; other site 443149001756 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 443149001757 putative active site [active] 443149001758 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 443149001759 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 443149001760 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 443149001761 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG1848 443149001762 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 443149001763 Sulfatase; Region: Sulfatase; pfam00884 443149001764 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 443149001765 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 443149001766 putative active site [active] 443149001767 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 443149001768 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 443149001769 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 443149001770 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 443149001771 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 443149001772 RPB10 interaction site [polypeptide binding]; other site 443149001773 RPB1 interaction site [polypeptide binding]; other site 443149001774 RPB11 interaction site [polypeptide binding]; other site 443149001775 RPB3 interaction site [polypeptide binding]; other site 443149001776 RPB12 interaction site [polypeptide binding]; other site 443149001777 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 443149001778 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 443149001779 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 443149001780 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 443149001781 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 443149001782 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 443149001783 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 443149001784 G-loop; other site 443149001785 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 443149001786 DNA binding site [nucleotide binding] 443149001787 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 443149001788 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; pfam04734 443149001789 endonuclease IV; Provisional; Region: PRK01060 443149001790 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 443149001791 AP (apurinic/apyrimidinic) site pocket; other site 443149001792 DNA interaction; other site 443149001793 Metal-binding active site; metal-binding site 443149001794 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 443149001795 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 443149001796 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 443149001797 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443149001798 active site 443149001799 enoyl-CoA hydratase; Provisional; Region: PRK12478 443149001800 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443149001801 substrate binding site [chemical binding]; other site 443149001802 oxyanion hole (OAH) forming residues; other site 443149001803 trimer interface [polypeptide binding]; other site 443149001804 Phenylacetic acid-responsive transcriptional repressor [Transcription]; Region: PaaX; COG3327 443149001805 PaaX-like protein; Region: PaaX; pfam07848 443149001806 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 443149001807 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 443149001808 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443149001809 substrate binding site [chemical binding]; other site 443149001810 oxyanion hole (OAH) forming residues; other site 443149001811 trimer interface [polypeptide binding]; other site 443149001812 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 443149001813 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 443149001814 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 443149001815 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 443149001816 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149001817 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149001818 WHG domain; Region: WHG; pfam13305 443149001819 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 443149001820 S17 interaction site [polypeptide binding]; other site 443149001821 S8 interaction site; other site 443149001822 16S rRNA interaction site [nucleotide binding]; other site 443149001823 streptomycin interaction site [chemical binding]; other site 443149001824 23S rRNA interaction site [nucleotide binding]; other site 443149001825 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 443149001826 30S ribosomal protein S7; Validated; Region: PRK05302 443149001827 elongation factor G; Reviewed; Region: PRK00007 443149001828 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 443149001829 G1 box; other site 443149001830 putative GEF interaction site [polypeptide binding]; other site 443149001831 GTP/Mg2+ binding site [chemical binding]; other site 443149001832 Switch I region; other site 443149001833 G2 box; other site 443149001834 G3 box; other site 443149001835 Switch II region; other site 443149001836 G4 box; other site 443149001837 G5 box; other site 443149001838 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 443149001839 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 443149001840 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 443149001841 elongation factor Tu; Reviewed; Region: PRK00049 443149001842 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 443149001843 G1 box; other site 443149001844 GEF interaction site [polypeptide binding]; other site 443149001845 GTP/Mg2+ binding site [chemical binding]; other site 443149001846 Switch I region; other site 443149001847 G2 box; other site 443149001848 G3 box; other site 443149001849 Switch II region; other site 443149001850 G4 box; other site 443149001851 G5 box; other site 443149001852 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 443149001853 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 443149001854 Antibiotic Binding Site [chemical binding]; other site 443149001855 Short C-terminal domain; Region: SHOCT; pfam09851 443149001856 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 443149001857 classical (c) SDRs; Region: SDR_c; cd05233 443149001858 NAD(P) binding site [chemical binding]; other site 443149001859 active site 443149001860 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 443149001861 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443149001862 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4427 443149001863 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 443149001864 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149001865 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 443149001866 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 443149001867 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443149001868 FeS/SAM binding site; other site 443149001869 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 443149001870 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 443149001871 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 443149001872 phosphate binding site [ion binding]; other site 443149001873 mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964 443149001874 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 443149001875 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 443149001876 Probable Catalytic site; other site 443149001877 metal-binding site 443149001878 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 443149001879 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 443149001880 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 443149001881 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 443149001882 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 443149001883 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 443149001884 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 443149001885 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 443149001886 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 443149001887 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 443149001888 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 443149001889 putative translocon binding site; other site 443149001890 protein-rRNA interface [nucleotide binding]; other site 443149001891 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 443149001892 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 443149001893 G-X-X-G motif; other site 443149001894 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 443149001895 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 443149001896 23S rRNA interface [nucleotide binding]; other site 443149001897 5S rRNA interface [nucleotide binding]; other site 443149001898 putative antibiotic binding site [chemical binding]; other site 443149001899 L25 interface [polypeptide binding]; other site 443149001900 L27 interface [polypeptide binding]; other site 443149001901 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 443149001902 putative translocon interaction site; other site 443149001903 23S rRNA interface [nucleotide binding]; other site 443149001904 signal recognition particle (SRP54) interaction site; other site 443149001905 L23 interface [polypeptide binding]; other site 443149001906 trigger factor interaction site; other site 443149001907 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 443149001908 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 443149001909 Sulfatase; Region: Sulfatase; pfam00884 443149001910 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353 443149001911 Uncharacterized conserved protein [Function unknown]; Region: COG1262 443149001912 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 443149001913 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 443149001914 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 443149001915 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 443149001916 RNA binding site [nucleotide binding]; other site 443149001917 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 443149001918 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 443149001919 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 443149001920 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 443149001921 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 443149001922 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 443149001923 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 443149001924 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 443149001925 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 443149001926 5S rRNA interface [nucleotide binding]; other site 443149001927 23S rRNA interface [nucleotide binding]; other site 443149001928 L5 interface [polypeptide binding]; other site 443149001929 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 443149001930 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 443149001931 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 443149001932 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 443149001933 23S rRNA binding site [nucleotide binding]; other site 443149001934 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 443149001935 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 443149001936 tandem repeat interface [polypeptide binding]; other site 443149001937 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 443149001938 oligomer interface [polypeptide binding]; other site 443149001939 active site residues [active] 443149001940 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 443149001941 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 443149001942 tandem repeat interface [polypeptide binding]; other site 443149001943 oligomer interface [polypeptide binding]; other site 443149001944 active site residues [active] 443149001945 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 443149001946 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 443149001947 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 443149001948 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 443149001949 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 443149001950 intersubunit interface [polypeptide binding]; other site 443149001951 active site 443149001952 Zn2+ binding site [ion binding]; other site 443149001953 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 443149001954 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 443149001955 NAD binding site [chemical binding]; other site 443149001956 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 443149001957 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 443149001958 nucleotide binding site [chemical binding]; other site 443149001959 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 443149001960 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443149001961 Coenzyme A binding pocket [chemical binding]; other site 443149001962 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 443149001963 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 443149001964 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 443149001965 SecY translocase; Region: SecY; pfam00344 443149001966 adenylate kinase; Reviewed; Region: adk; PRK00279 443149001967 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 443149001968 AMP-binding site [chemical binding]; other site 443149001969 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 443149001970 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 443149001971 active site 443149001972 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 443149001973 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443149001974 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443149001975 DNA binding residues [nucleotide binding] 443149001976 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 443149001977 Putative zinc-finger; Region: zf-HC2; pfam13490 443149001978 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 443149001979 PYR/PP interface [polypeptide binding]; other site 443149001980 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 443149001981 MarR family; Region: MarR; pfam01047 443149001982 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 443149001983 TIGR03086 family protein; Region: TIGR03086 443149001984 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 443149001985 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 443149001986 Transposase; Region: DDE_Tnp_ISL3; pfam01610 443149001987 Helix-turn-helix domain; Region: HTH_17; pfam12728 443149001988 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 443149001989 PE family; Region: PE; pfam00934 443149001990 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 443149001991 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 443149001992 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 443149001993 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 443149001994 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149001995 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443149001996 active site 443149001997 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 443149001998 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 443149001999 tetrameric interface [polypeptide binding]; other site 443149002000 NAD binding site [chemical binding]; other site 443149002001 catalytic residues [active] 443149002002 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 443149002003 catalytic core [active] 443149002004 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149002005 PPE family; Region: PPE; pfam00823 443149002006 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149002007 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149002008 Helix-turn-helix domain; Region: HTH_28; pfam13518 443149002009 Winged helix-turn helix; Region: HTH_29; pfam13551 443149002010 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 443149002011 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443149002012 active site 443149002013 phosphorylation site [posttranslational modification] 443149002014 intermolecular recognition site; other site 443149002015 dimerization interface [polypeptide binding]; other site 443149002016 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443149002017 DNA binding site [nucleotide binding] 443149002018 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443149002019 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443149002020 dimerization interface [polypeptide binding]; other site 443149002021 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443149002022 dimer interface [polypeptide binding]; other site 443149002023 phosphorylation site [posttranslational modification] 443149002024 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443149002025 ATP binding site [chemical binding]; other site 443149002026 Mg2+ binding site [ion binding]; other site 443149002027 G-X-G motif; other site 443149002028 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 443149002029 nucleotide binding site/active site [active] 443149002030 HIT family signature motif; other site 443149002031 catalytic residue [active] 443149002032 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 443149002033 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 443149002034 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 443149002035 NAD binding site [chemical binding]; other site 443149002036 catalytic Zn binding site [ion binding]; other site 443149002037 substrate binding site [chemical binding]; other site 443149002038 structural Zn binding site [ion binding]; other site 443149002039 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 443149002040 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 443149002041 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 443149002042 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443149002043 Cytochrome P450; Region: p450; cl12078 443149002044 short chain dehydrogenase; Provisional; Region: PRK07775 443149002045 classical (c) SDRs; Region: SDR_c; cd05233 443149002046 NAD(P) binding site [chemical binding]; other site 443149002047 active site 443149002048 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443149002049 Cytochrome P450; Region: p450; cl12078 443149002050 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149002051 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 443149002052 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 443149002053 NAD binding site [chemical binding]; other site 443149002054 catalytic residues [active] 443149002055 short chain dehydrogenase; Provisional; Region: PRK07774 443149002056 classical (c) SDRs; Region: SDR_c; cd05233 443149002057 NAD(P) binding site [chemical binding]; other site 443149002058 active site 443149002059 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 443149002060 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 443149002061 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 443149002062 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 443149002063 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 443149002064 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 443149002065 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 443149002066 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 443149002067 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 443149002068 Predicted esterase [General function prediction only]; Region: COG0627 443149002069 S-formylglutathione hydrolase; Region: PLN02442 443149002070 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 443149002071 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 443149002072 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 443149002073 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 443149002074 tetramer interface [polypeptide binding]; other site 443149002075 active site 443149002076 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443149002077 Cytochrome P450; Region: p450; cl12078 443149002078 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 443149002079 ATP binding site [chemical binding]; other site 443149002080 active site 443149002081 substrate binding site [chemical binding]; other site 443149002082 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 443149002083 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 443149002084 WHG domain; Region: WHG; pfam13305 443149002085 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 443149002086 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443149002087 putative substrate translocation pore; other site 443149002088 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443149002089 Predicted deacetylase [General function prediction only]; Region: COG3233 443149002090 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 443149002091 putative active site [active] 443149002092 putative Zn binding site [ion binding]; other site 443149002093 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 443149002094 FAD binding domain; Region: FAD_binding_2; pfam00890 443149002095 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 443149002096 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 443149002097 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 443149002098 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 443149002099 putative active site [active] 443149002100 catalytic triad [active] 443149002101 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 443149002102 Transglutaminase/protease-like homologues; Region: TGc; smart00460 443149002103 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 443149002104 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 443149002105 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 443149002106 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 443149002107 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443149002108 DNA-binding site [nucleotide binding]; DNA binding site 443149002109 UTRA domain; Region: UTRA; pfam07702 443149002110 Uncharacterized conserved protein [Function unknown]; Region: COG1359 443149002111 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 443149002112 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 443149002113 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443149002114 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 443149002115 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 443149002116 Transposase; Region: HTH_Tnp_1; cl17663 443149002117 putative transposase OrfB; Reviewed; Region: PHA02517 443149002118 HTH-like domain; Region: HTH_21; pfam13276 443149002119 Integrase core domain; Region: rve; pfam00665 443149002120 Integrase core domain; Region: rve_3; pfam13683 443149002121 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 443149002122 Transposase; Region: DEDD_Tnp_IS110; pfam01548 443149002123 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 443149002124 Uncharacterized protein, linocin/CFP29 homolog [Function unknown]; Region: COG1659 443149002125 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 443149002126 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 443149002127 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 443149002128 active site 443149002129 metal binding site [ion binding]; metal-binding site 443149002130 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 443149002131 active site 443149002132 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443149002133 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 443149002134 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 443149002135 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 443149002136 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 443149002137 dimerization interface [polypeptide binding]; other site 443149002138 ATP binding site [chemical binding]; other site 443149002139 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 443149002140 dimerization interface [polypeptide binding]; other site 443149002141 ATP binding site [chemical binding]; other site 443149002142 CAAX protease self-immunity; Region: Abi; pfam02517 443149002143 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 443149002144 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 443149002145 active site 443149002146 metal binding site [ion binding]; metal-binding site 443149002147 hexamer interface [polypeptide binding]; other site 443149002148 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 443149002149 amidophosphoribosyltransferase; Provisional; Region: PRK07847 443149002150 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 443149002151 active site 443149002152 tetramer interface [polypeptide binding]; other site 443149002153 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 443149002154 active site 443149002155 phosphoribosylaminoimidazole synthetase; Region: purM; TIGR00878 443149002156 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 443149002157 dimerization interface [polypeptide binding]; other site 443149002158 putative ATP binding site [chemical binding]; other site 443149002159 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 443149002160 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 443149002161 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 443149002162 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 443149002163 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 443149002164 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443149002165 catalytic residue [active] 443149002166 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 443149002167 heme-binding site [chemical binding]; other site 443149002168 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 443149002169 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 443149002170 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 443149002171 active site residue [active] 443149002172 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 443149002173 active site residue [active] 443149002174 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 443149002175 catalytic residues [active] 443149002176 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 443149002177 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 443149002178 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443149002179 DNA binding site [nucleotide binding] 443149002180 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 443149002181 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443149002182 Coenzyme A binding pocket [chemical binding]; other site 443149002183 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 443149002184 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 443149002185 Walker A/P-loop; other site 443149002186 ATP binding site [chemical binding]; other site 443149002187 Q-loop/lid; other site 443149002188 ABC transporter signature motif; other site 443149002189 Walker B; other site 443149002190 D-loop; other site 443149002191 H-loop/switch region; other site 443149002192 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 443149002193 PhoU domain; Region: PhoU; pfam01895 443149002194 PhoU domain; Region: PhoU; pfam01895 443149002195 cell envelope-related function transcriptional attenuator common domain; Region: lytR_cpsA_psr; TIGR00350 443149002196 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 443149002197 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 443149002198 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 443149002199 FMN binding site [chemical binding]; other site 443149002200 active site 443149002201 catalytic residues [active] 443149002202 substrate binding site [chemical binding]; other site 443149002203 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 443149002204 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 443149002205 homodimer interface [polypeptide binding]; other site 443149002206 putative substrate binding pocket [chemical binding]; other site 443149002207 diiron center [ion binding]; other site 443149002208 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149002209 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 443149002210 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443149002211 dimerization interface [polypeptide binding]; other site 443149002212 putative DNA binding site [nucleotide binding]; other site 443149002213 putative Zn2+ binding site [ion binding]; other site 443149002214 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 443149002215 dimer interface [polypeptide binding]; other site 443149002216 catalytic motif [active] 443149002217 nucleoside/Zn binding site; other site 443149002218 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 443149002219 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 443149002220 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 443149002221 TIGR04255 family protein; Region: sporadTIGR04255 443149002222 PE family; Region: PE; pfam00934 443149002223 PE family; Region: PE; pfam00934 443149002224 PknH-like extracellular domain; Region: PknH_C; pfam14032 443149002225 Predicted nucleotidyltransferase [General function prediction only]; Region: COG4849 443149002226 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4861 443149002227 Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952 443149002228 D-ala-D-ala dipeptidase; Region: Peptidase_M15; pfam01427 443149002229 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149002230 S-adenosylmethionine binding site [chemical binding]; other site 443149002231 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 443149002232 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443149002233 putative substrate translocation pore; other site 443149002234 Major Facilitator Superfamily; Region: MFS_1; pfam07690 443149002235 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 443149002236 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 443149002237 tetramer interface [polypeptide binding]; other site 443149002238 TPP-binding site [chemical binding]; other site 443149002239 heterodimer interface [polypeptide binding]; other site 443149002240 phosphorylation loop region [posttranslational modification] 443149002241 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443149002242 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443149002243 active site 443149002244 phosphorylation site [posttranslational modification] 443149002245 intermolecular recognition site; other site 443149002246 dimerization interface [polypeptide binding]; other site 443149002247 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443149002248 DNA binding residues [nucleotide binding] 443149002249 dimerization interface [polypeptide binding]; other site 443149002250 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 443149002251 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 443149002252 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 443149002253 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 443149002254 Multicopper oxidase; Region: Cu-oxidase; pfam00394 443149002255 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 443149002256 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 443149002257 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 443149002258 dimer interface [polypeptide binding]; other site 443149002259 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443149002260 catalytic residue [active] 443149002261 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443149002262 multidrug resistance protein MdtH; Provisional; Region: PRK11646 443149002263 putative substrate translocation pore; other site 443149002264 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 443149002265 short chain dehydrogenase; Provisional; Region: PRK05876 443149002266 classical (c) SDRs; Region: SDR_c; cd05233 443149002267 NAD(P) binding site [chemical binding]; other site 443149002268 active site 443149002269 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443149002270 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 443149002271 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 443149002272 dimer interface [polypeptide binding]; other site 443149002273 PYR/PP interface [polypeptide binding]; other site 443149002274 TPP binding site [chemical binding]; other site 443149002275 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 443149002276 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 443149002277 TPP-binding site [chemical binding]; other site 443149002278 dimer interface [polypeptide binding]; other site 443149002279 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 443149002280 putative hydrophobic ligand binding site [chemical binding]; other site 443149002281 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 443149002282 CoA-transferase family III; Region: CoA_transf_3; pfam02515 443149002283 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 443149002284 putative hydrophobic ligand binding site [chemical binding]; other site 443149002285 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 443149002286 putative hydrophobic ligand binding site [chemical binding]; other site 443149002287 aminotransferase; Validated; Region: PRK07777 443149002288 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443149002289 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443149002290 homodimer interface [polypeptide binding]; other site 443149002291 catalytic residue [active] 443149002292 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 443149002293 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 443149002294 dimer interface [polypeptide binding]; other site 443149002295 active site 443149002296 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 443149002297 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443149002298 substrate binding site [chemical binding]; other site 443149002299 oxyanion hole (OAH) forming residues; other site 443149002300 trimer interface [polypeptide binding]; other site 443149002301 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 443149002302 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 443149002303 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 443149002304 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 443149002305 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443149002306 ATP binding site [chemical binding]; other site 443149002307 putative Mg++ binding site [ion binding]; other site 443149002308 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443149002309 nucleotide binding region [chemical binding]; other site 443149002310 ATP-binding site [chemical binding]; other site 443149002311 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 443149002312 WYL domain; Region: WYL; pfam13280 443149002313 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 443149002314 trimer interface [polypeptide binding]; other site 443149002315 dimer interface [polypeptide binding]; other site 443149002316 putative active site [active] 443149002317 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 443149002318 MPT binding site; other site 443149002319 trimer interface [polypeptide binding]; other site 443149002320 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 443149002321 MoaE homodimer interface [polypeptide binding]; other site 443149002322 MoaD interaction [polypeptide binding]; other site 443149002323 active site residues [active] 443149002324 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 443149002325 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 443149002326 MoaE interaction surface [polypeptide binding]; other site 443149002327 MoeB interaction surface [polypeptide binding]; other site 443149002328 thiocarboxylated glycine; other site 443149002329 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 443149002330 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443149002331 FeS/SAM binding site; other site 443149002332 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 443149002333 hypothetical protein; Provisional; Region: PRK11770 443149002334 Domain of unknown function (DUF307); Region: DUF307; pfam03733 443149002335 Domain of unknown function (DUF307); Region: DUF307; pfam03733 443149002336 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 443149002337 DNA-binding site [nucleotide binding]; DNA binding site 443149002338 RNA-binding motif; other site 443149002339 PE family; Region: PE; pfam00934 443149002340 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443149002341 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149002342 active site 443149002343 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 443149002344 FIST N domain; Region: FIST; pfam08495 443149002345 FIST C domain; Region: FIST_C; pfam10442 443149002346 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 443149002347 H+ Antiporter protein; Region: 2A0121; TIGR00900 443149002348 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 443149002349 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149002350 PPE family; Region: PPE; pfam00823 443149002351 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149002352 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149002353 Protein of unknown function (DUF2530); Region: DUF2530; pfam10745 443149002354 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 443149002355 MarR family; Region: MarR; pfam01047 443149002356 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 443149002357 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 443149002358 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 443149002359 Protein of unknown function (DUF2537); Region: DUF2537; pfam10801 443149002360 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 443149002361 phosphoserine aminotransferase, putative; Region: serC_3; TIGR01366 443149002362 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443149002363 catalytic residue [active] 443149002364 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 443149002365 Ferredoxin [Energy production and conversion]; Region: COG1146 443149002366 4Fe-4S binding domain; Region: Fer4; pfam00037 443149002367 ferredoxin-NADP+ reductase; Region: PLN02852 443149002368 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 443149002369 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 443149002370 putative dimer interface [polypeptide binding]; other site 443149002371 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443149002372 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 443149002373 putative catalytic site [active] 443149002374 putative phosphate binding site [ion binding]; other site 443149002375 putative metal binding site [ion binding]; other site 443149002376 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 443149002377 dimer interface [polypeptide binding]; other site 443149002378 Citrate synthase; Region: Citrate_synt; pfam00285 443149002379 active site 443149002380 citrylCoA binding site [chemical binding]; other site 443149002381 oxalacetate/citrate binding site [chemical binding]; other site 443149002382 coenzyme A binding site [chemical binding]; other site 443149002383 catalytic triad [active] 443149002384 Predicted ATPase [General function prediction only]; Region: COG3903 443149002385 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443149002386 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443149002387 DNA binding residues [nucleotide binding] 443149002388 dimerization interface [polypeptide binding]; other site 443149002389 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 443149002390 cyclase homology domain; Region: CHD; cd07302 443149002391 nucleotidyl binding site; other site 443149002392 metal binding site [ion binding]; metal-binding site 443149002393 dimer interface [polypeptide binding]; other site 443149002394 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 443149002395 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 443149002396 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 443149002397 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 443149002398 AAA ATPase domain; Region: AAA_16; pfam13191 443149002399 Predicted ATPase [General function prediction only]; Region: COG3903 443149002400 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443149002401 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443149002402 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 443149002403 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 443149002404 dimer interface [polypeptide binding]; other site 443149002405 active site 443149002406 citrylCoA binding site [chemical binding]; other site 443149002407 NADH binding [chemical binding]; other site 443149002408 cationic pore residues; other site 443149002409 oxalacetate/citrate binding site [chemical binding]; other site 443149002410 coenzyme A binding site [chemical binding]; other site 443149002411 catalytic triad [active] 443149002412 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 443149002413 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 443149002414 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 443149002415 BON domain; Region: BON; pfam04972 443149002416 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 443149002417 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 443149002418 ligand binding site [chemical binding]; other site 443149002419 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 443149002420 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443149002421 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443149002422 dimerization interface [polypeptide binding]; other site 443149002423 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443149002424 dimer interface [polypeptide binding]; other site 443149002425 phosphorylation site [posttranslational modification] 443149002426 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443149002427 Mg2+ binding site [ion binding]; other site 443149002428 G-X-G motif; other site 443149002429 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 443149002430 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443149002431 active site 443149002432 phosphorylation site [posttranslational modification] 443149002433 intermolecular recognition site; other site 443149002434 dimerization interface [polypeptide binding]; other site 443149002435 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443149002436 DNA binding site [nucleotide binding] 443149002437 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 443149002438 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; COG0825 443149002439 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 443149002440 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443149002441 substrate binding site [chemical binding]; other site 443149002442 oxyanion hole (OAH) forming residues; other site 443149002443 trimer interface [polypeptide binding]; other site 443149002444 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 443149002445 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 443149002446 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 443149002447 Beta-lactamase; Region: Beta-lactamase; pfam00144 443149002448 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 443149002449 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 443149002450 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 443149002451 Soluble P-type ATPase [General function prediction only]; Region: COG4087 443149002452 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 443149002453 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 443149002454 hydrophobic ligand binding site; other site 443149002455 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 443149002456 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443149002457 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 443149002458 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443149002459 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 443149002460 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 443149002461 acetyl-CoA acetyltransferase; Provisional; Region: PRK06289 443149002462 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 443149002463 active site 443149002464 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149002465 PPE family; Region: PPE; pfam00823 443149002466 PE family; Region: PE; pfam00934 443149002467 BCCT family transporter; Region: BCCT; pfam02028 443149002468 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 443149002469 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443149002470 Coenzyme A binding pocket [chemical binding]; other site 443149002471 Transposase, Mutator family; Region: Transposase_mut; pfam00872 443149002472 MULE transposase domain; Region: MULE; pfam10551 443149002473 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 443149002474 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 443149002475 catalytic residues [active] 443149002476 catalytic nucleophile [active] 443149002477 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 443149002478 Probable transposase; Region: OrfB_IS605; pfam01385 443149002479 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 443149002480 putative active site pocket [active] 443149002481 dimerization interface [polypeptide binding]; other site 443149002482 putative catalytic residue [active] 443149002483 Phage-related replication protein [General function prediction only]; Region: COG4195 443149002484 manganese transport protein MntH; Reviewed; Region: PRK00701 443149002485 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 443149002486 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 443149002487 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 443149002488 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 443149002489 short chain dehydrogenase; Provisional; Region: PRK07814 443149002490 classical (c) SDRs; Region: SDR_c; cd05233 443149002491 NAD(P) binding site [chemical binding]; other site 443149002492 active site 443149002493 phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975 443149002494 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 443149002495 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443149002496 dimer interface [polypeptide binding]; other site 443149002497 conserved gate region; other site 443149002498 putative PBP binding loops; other site 443149002499 ABC-ATPase subunit interface; other site 443149002500 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 443149002501 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443149002502 dimer interface [polypeptide binding]; other site 443149002503 conserved gate region; other site 443149002504 putative PBP binding loops; other site 443149002505 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 443149002506 ABC-ATPase subunit interface; other site 443149002507 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 443149002508 Catalytic domain of Protein Kinases; Region: PKc; cd00180 443149002509 active site 443149002510 ATP binding site [chemical binding]; other site 443149002511 substrate binding site [chemical binding]; other site 443149002512 activation loop (A-loop); other site 443149002513 Uncharacterized conserved protein [Function unknown]; Region: COG3391 443149002514 NHL repeat; Region: NHL; pfam01436 443149002515 NHL repeat; Region: NHL; pfam01436 443149002516 NHL repeat; Region: NHL; pfam01436 443149002517 NHL repeat; Region: NHL; pfam01436 443149002518 NHL repeat; Region: NHL; pfam01436 443149002519 PBP superfamily domain; Region: PBP_like_2; cl17296 443149002520 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14271 443149002521 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 443149002522 Walker A/P-loop; other site 443149002523 ATP binding site [chemical binding]; other site 443149002524 Q-loop/lid; other site 443149002525 ABC transporter signature motif; other site 443149002526 Walker B; other site 443149002527 D-loop; other site 443149002528 H-loop/switch region; other site 443149002529 phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975 443149002530 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 443149002531 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443149002532 dimer interface [polypeptide binding]; other site 443149002533 conserved gate region; other site 443149002534 putative PBP binding loops; other site 443149002535 ABC-ATPase subunit interface; other site 443149002536 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 443149002537 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443149002538 dimer interface [polypeptide binding]; other site 443149002539 conserved gate region; other site 443149002540 putative PBP binding loops; other site 443149002541 ABC-ATPase subunit interface; other site 443149002542 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 443149002543 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 443149002544 putative DNA binding site [nucleotide binding]; other site 443149002545 putative homodimer interface [polypeptide binding]; other site 443149002546 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 443149002547 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 443149002548 nucleotide binding site [chemical binding]; other site 443149002549 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 443149002550 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 443149002551 active site 443149002552 DNA binding site [nucleotide binding] 443149002553 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 443149002554 DNA binding site [nucleotide binding] 443149002555 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 443149002556 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 443149002557 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 443149002558 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 443149002559 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 443149002560 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 443149002561 anti sigma factor interaction site; other site 443149002562 regulatory phosphorylation site [posttranslational modification]; other site 443149002563 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 443149002564 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 443149002565 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 443149002566 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 443149002567 short chain dehydrogenase; Provisional; Region: PRK08251 443149002568 classical (c) SDR, subgroup 6; Region: SDR_c6; cd05350 443149002569 putative NAD(P) binding site [chemical binding]; other site 443149002570 active site 443149002571 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 443149002572 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 443149002573 active site 443149002574 dimer interface [polypeptide binding]; other site 443149002575 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 443149002576 dimer interface [polypeptide binding]; other site 443149002577 active site 443149002578 Predicted esterase [General function prediction only]; Region: COG0627 443149002579 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 443149002580 hypothetical protein; Provisional; Region: PRK07857 443149002581 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 443149002582 Part of AAA domain; Region: AAA_19; pfam13245 443149002583 Family description; Region: UvrD_C_2; pfam13538 443149002584 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 443149002585 Peptidase family M23; Region: Peptidase_M23; pfam01551 443149002586 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 443149002587 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 443149002588 CoA-ligase; Region: Ligase_CoA; pfam00549 443149002589 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 443149002590 CoA binding domain; Region: CoA_binding; smart00881 443149002591 CoA-ligase; Region: Ligase_CoA; pfam00549 443149002592 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 443149002593 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 443149002594 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 443149002595 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 443149002596 active site 443149002597 substrate binding site [chemical binding]; other site 443149002598 cosubstrate binding site; other site 443149002599 catalytic site [active] 443149002600 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 443149002601 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 443149002602 purine monophosphate binding site [chemical binding]; other site 443149002603 dimer interface [polypeptide binding]; other site 443149002604 putative catalytic residues [active] 443149002605 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 443149002606 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 443149002607 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 443149002608 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 443149002609 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 443149002610 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 443149002611 metal ion-dependent adhesion site (MIDAS); other site 443149002612 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 443149002613 homotetrameric interface [polypeptide binding]; other site 443149002614 putative active site [active] 443149002615 metal binding site [ion binding]; metal-binding site 443149002616 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 443149002617 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 443149002618 Thermus thermophilus CsoR, a Cu(I)-sensing transcriptional regulator, and related domains; this domain family was previously known as part of DUF156; Region: TthCsoR-like_DUF156; cd10151 443149002619 putative homodimer interface [polypeptide binding]; other site 443149002620 putative homotetramer interface [polypeptide binding]; other site 443149002621 allosteric switch controlling residues; other site 443149002622 putative metal binding site [ion binding]; other site 443149002623 putative homodimer-homodimer interface [polypeptide binding]; other site 443149002624 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 443149002625 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 443149002626 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 443149002627 Soluble P-type ATPase [General function prediction only]; Region: COG4087 443149002628 enoyl-CoA hydratase; Provisional; Region: PRK07827 443149002629 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443149002630 substrate binding site [chemical binding]; other site 443149002631 oxyanion hole (OAH) forming residues; other site 443149002632 trimer interface [polypeptide binding]; other site 443149002633 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149002634 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 443149002635 active site 443149002636 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 443149002637 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 443149002638 ATP-grasp domain; Region: ATP-grasp_4; cl17255 443149002639 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 443149002640 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 443149002641 carboxyltransferase (CT) interaction site; other site 443149002642 biotinylation site [posttranslational modification]; other site 443149002643 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 443149002644 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 443149002645 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149002646 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443149002647 active site 443149002648 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 443149002649 PE family; Region: PE; pfam00934 443149002650 PE family; Region: PE; pfam00934 443149002651 Uncharacterized conserved protein [Function unknown]; Region: COG3391 443149002652 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 443149002653 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 443149002654 PE family; Region: PE; pfam00934 443149002655 Uncharacterized conserved protein [Function unknown]; Region: COG3391 443149002656 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 443149002657 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 443149002658 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 443149002659 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 443149002660 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443149002661 active site 443149002662 phosphorylation site [posttranslational modification] 443149002663 intermolecular recognition site; other site 443149002664 dimerization interface [polypeptide binding]; other site 443149002665 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443149002666 DNA binding site [nucleotide binding] 443149002667 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 443149002668 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443149002669 dimerization interface [polypeptide binding]; other site 443149002670 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443149002671 dimer interface [polypeptide binding]; other site 443149002672 phosphorylation site [posttranslational modification] 443149002673 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443149002674 ATP binding site [chemical binding]; other site 443149002675 Mg2+ binding site [ion binding]; other site 443149002676 G-X-G motif; other site 443149002677 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 443149002678 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 443149002679 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 443149002680 MPT binding site; other site 443149002681 trimer interface [polypeptide binding]; other site 443149002682 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 443149002683 Large-conductance mechanosensitive channel, MscL; Region: MscL; pfam01741 443149002684 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 443149002685 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 443149002686 Walker A/P-loop; other site 443149002687 ATP binding site [chemical binding]; other site 443149002688 Q-loop/lid; other site 443149002689 ABC transporter signature motif; other site 443149002690 Walker B; other site 443149002691 D-loop; other site 443149002692 H-loop/switch region; other site 443149002693 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 443149002694 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 443149002695 FtsX-like permease family; Region: FtsX; pfam02687 443149002696 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 443149002697 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 443149002698 FtsX-like permease family; Region: FtsX; pfam02687 443149002699 Predicted secreted hydrolase [General function prediction only]; Region: COG5621 443149002700 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 443149002701 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 443149002702 substrate binding pocket [chemical binding]; other site 443149002703 chain length determination region; other site 443149002704 substrate-Mg2+ binding site; other site 443149002705 catalytic residues [active] 443149002706 aspartate-rich region 1; other site 443149002707 active site lid residues [active] 443149002708 aspartate-rich region 2; other site 443149002709 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 443149002710 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2331 443149002711 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 443149002712 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 443149002713 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 443149002714 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 443149002715 active site 443149002716 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 443149002717 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 443149002718 dimer interface [polypeptide binding]; other site 443149002719 putative functional site; other site 443149002720 putative MPT binding site; other site 443149002721 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 443149002722 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 443149002723 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149002724 S-adenosylmethionine binding site [chemical binding]; other site 443149002725 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 443149002726 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 443149002727 ligand binding site [chemical binding]; other site 443149002728 flexible hinge region; other site 443149002729 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 443149002730 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443149002731 Coenzyme A binding pocket [chemical binding]; other site 443149002732 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 443149002733 arginine deiminase; Provisional; Region: PRK01388 443149002734 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 443149002735 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 443149002736 Predicted methyltransferases [General function prediction only]; Region: COG0313 443149002737 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 443149002738 putative SAM binding site [chemical binding]; other site 443149002739 putative homodimer interface [polypeptide binding]; other site 443149002740 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 443149002741 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 443149002742 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 443149002743 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 443149002744 active site 443149002745 HIGH motif; other site 443149002746 KMSKS motif; other site 443149002747 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 443149002748 tRNA binding surface [nucleotide binding]; other site 443149002749 anticodon binding site; other site 443149002750 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 443149002751 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 443149002752 active site 443149002753 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 443149002754 Domain of unknown function (DUF348); Region: DUF348; pfam03990 443149002755 Domain of unknown function (DUF348); Region: DUF348; pfam03990 443149002756 G5 domain; Region: G5; pfam07501 443149002757 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 443149002758 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 443149002759 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149002760 S-adenosylmethionine binding site [chemical binding]; other site 443149002761 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 443149002762 Increased loss of mitochondrial DNA protein 1; Region: Ilm1; pfam10311 443149002763 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 443149002764 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 443149002765 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443149002766 acyl-activating enzyme (AAE) consensus motif; other site 443149002767 AMP binding site [chemical binding]; other site 443149002768 active site 443149002769 CoA binding site [chemical binding]; other site 443149002770 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 443149002771 putative active site [active] 443149002772 catalytic residue [active] 443149002773 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 443149002774 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 443149002775 5S rRNA interface [nucleotide binding]; other site 443149002776 CTC domain interface [polypeptide binding]; other site 443149002777 L16 interface [polypeptide binding]; other site 443149002778 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 443149002779 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 443149002780 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 443149002781 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 443149002782 active site 443149002783 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 443149002784 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 443149002785 Substrate binding site; other site 443149002786 Mg++ binding site; other site 443149002787 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 443149002788 active site 443149002789 substrate binding site [chemical binding]; other site 443149002790 CoA binding site [chemical binding]; other site 443149002791 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149002792 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149002793 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 443149002794 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 443149002795 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443149002796 ATP binding site [chemical binding]; other site 443149002797 putative Mg++ binding site [ion binding]; other site 443149002798 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443149002799 nucleotide binding region [chemical binding]; other site 443149002800 ATP-binding site [chemical binding]; other site 443149002801 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 443149002802 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 443149002803 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 443149002804 homodimer interface [polypeptide binding]; other site 443149002805 metal binding site [ion binding]; metal-binding site 443149002806 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 443149002807 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 443149002808 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 443149002809 N-acetyl-D-glucosamine binding site [chemical binding]; other site 443149002810 enolase; Provisional; Region: eno; PRK00077 443149002811 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 443149002812 dimer interface [polypeptide binding]; other site 443149002813 metal binding site [ion binding]; metal-binding site 443149002814 substrate binding pocket [chemical binding]; other site 443149002815 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 443149002816 Septum formation initiator; Region: DivIC; pfam04977 443149002817 Uncharacterized conserved protein [Function unknown]; Region: COG1507 443149002818 exopolyphosphatase; Region: exo_poly_only; TIGR03706 443149002819 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 443149002820 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 443149002821 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443149002822 active site 443149002823 phosphorylation site [posttranslational modification] 443149002824 intermolecular recognition site; other site 443149002825 dimerization interface [polypeptide binding]; other site 443149002826 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443149002827 DNA binding site [nucleotide binding] 443149002828 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 443149002829 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 443149002830 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 443149002831 Ligand Binding Site [chemical binding]; other site 443149002832 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443149002833 dimer interface [polypeptide binding]; other site 443149002834 phosphorylation site [posttranslational modification] 443149002835 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443149002836 ATP binding site [chemical binding]; other site 443149002837 Mg2+ binding site [ion binding]; other site 443149002838 G-X-G motif; other site 443149002839 K+-transporting ATPase, KdpA; Region: kdpA; TIGR00680 443149002840 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 443149002841 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 443149002842 Soluble P-type ATPase [General function prediction only]; Region: COG4087 443149002843 potassium-transporting ATPase subunit C; Provisional; Region: PRK14001 443149002844 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443149002845 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443149002846 dimer interface [polypeptide binding]; other site 443149002847 phosphorylation site [posttranslational modification] 443149002848 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443149002849 ATP binding site [chemical binding]; other site 443149002850 Mg2+ binding site [ion binding]; other site 443149002851 G-X-G motif; other site 443149002852 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 443149002853 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443149002854 active site 443149002855 phosphorylation site [posttranslational modification] 443149002856 intermolecular recognition site; other site 443149002857 dimerization interface [polypeptide binding]; other site 443149002858 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443149002859 DNA binding site [nucleotide binding] 443149002860 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 443149002861 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 443149002862 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 443149002863 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 443149002864 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 443149002865 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149002866 PPE family; Region: PPE; pfam00823 443149002867 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 443149002868 PE family; Region: PE; pfam00934 443149002869 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 443149002870 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 443149002871 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 443149002872 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 443149002873 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 443149002874 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 443149002875 Predicted transcriptional regulator [Transcription]; Region: COG5340 443149002876 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 443149002877 Transposase, Mutator family; Region: Transposase_mut; pfam00872 443149002878 MULE transposase domain; Region: MULE; pfam10551 443149002879 Transcriptional regulators [Transcription]; Region: MarR; COG1846 443149002880 MarR family; Region: MarR_2; pfam12802 443149002881 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443149002882 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 443149002883 NAD(P) binding site [chemical binding]; other site 443149002884 active site 443149002885 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 443149002886 Helix-turn-helix domain; Region: HTH_17; pfam12728 443149002887 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 443149002888 Domain of unknown function (DUF427); Region: DUF427; cl00998 443149002889 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 443149002890 Domain of unknown function (DUF222); Region: DUF222; pfam02720 443149002891 Uncharacterized conserved protein [Function unknown]; Region: COG3391 443149002892 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 443149002893 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 443149002894 dimer interface [polypeptide binding]; other site 443149002895 acyl-activating enzyme (AAE) consensus motif; other site 443149002896 putative active site [active] 443149002897 AMP binding site [chemical binding]; other site 443149002898 putative CoA binding site [chemical binding]; other site 443149002899 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 443149002900 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 443149002901 hydrophobic ligand binding site; other site 443149002902 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 443149002903 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 443149002904 putative active site [active] 443149002905 putative dimer interface [polypeptide binding]; other site 443149002906 Patatin-like phospholipase; Region: Patatin; pfam01734 443149002907 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 443149002908 nucleophile elbow; other site 443149002909 hypothetical protein; Provisional; Region: PRK10279 443149002910 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 443149002911 active site 443149002912 nucleophile elbow; other site 443149002913 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 443149002914 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 443149002915 active site residue [active] 443149002916 PE family; Region: PE; pfam00934 443149002917 PE family; Region: PE; pfam00934 443149002918 Predicted membrane protein [Function unknown]; Region: COG4425 443149002919 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 443149002920 enoyl-CoA hydratase; Provisional; Region: PRK05862 443149002921 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443149002922 substrate binding site [chemical binding]; other site 443149002923 oxyanion hole (OAH) forming residues; other site 443149002924 trimer interface [polypeptide binding]; other site 443149002925 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 443149002926 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443149002927 substrate binding site [chemical binding]; other site 443149002928 oxyanion hole (OAH) forming residues; other site 443149002929 trimer interface [polypeptide binding]; other site 443149002930 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 443149002931 Predicted membrane protein [Function unknown]; Region: COG4760 443149002932 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 443149002933 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 443149002934 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 443149002935 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 443149002936 dimer interface [polypeptide binding]; other site 443149002937 active site 443149002938 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 443149002939 active site 443149002940 catalytic triad [active] 443149002941 oxyanion hole [active] 443149002942 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 443149002943 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 443149002944 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 443149002945 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 443149002946 dimer interface [polypeptide binding]; other site 443149002947 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443149002948 catalytic residue [active] 443149002949 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 443149002950 RDD family; Region: RDD; pfam06271 443149002951 cystathionine gamma-synthase; Provisional; Region: PRK07811 443149002952 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 443149002953 homodimer interface [polypeptide binding]; other site 443149002954 substrate-cofactor binding pocket; other site 443149002955 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443149002956 catalytic residue [active] 443149002957 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 443149002958 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 443149002959 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 443149002960 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 443149002961 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 443149002962 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 443149002963 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 443149002964 catalytic residues [active] 443149002965 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 443149002966 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 443149002967 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 443149002968 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 443149002969 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 443149002970 catalytic residue [active] 443149002971 putative FPP diphosphate binding site; other site 443149002972 putative FPP binding hydrophobic cleft; other site 443149002973 dimer interface [polypeptide binding]; other site 443149002974 putative IPP diphosphate binding site; other site 443149002975 PE family; Region: PE; pfam00934 443149002976 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 443149002977 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 443149002978 putative IPP diphosphate binding site; other site 443149002979 PE family; Region: PE; pfam00934 443149002980 CBD_II domain; Region: CBD_II; smart00637 443149002981 Glycosyl hydrolase family 12; Region: Glyco_hydro_12; pfam01670 443149002982 PE family; Region: PE; pfam00934 443149002983 pantothenate kinase; Provisional; Region: PRK05439 443149002984 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 443149002985 ATP-binding site [chemical binding]; other site 443149002986 CoA-binding site [chemical binding]; other site 443149002987 Mg2+-binding site [ion binding]; other site 443149002988 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 443149002989 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 443149002990 dimer interface [polypeptide binding]; other site 443149002991 active site 443149002992 glycine-pyridoxal phosphate binding site [chemical binding]; other site 443149002993 folate binding site [chemical binding]; other site 443149002994 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 443149002995 dinuclear metal binding motif [ion binding]; other site 443149002996 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 443149002997 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 443149002998 putative active site [active] 443149002999 PhoH-like protein; Region: PhoH; pfam02562 443149003000 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 443149003001 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 443149003002 NodB motif; other site 443149003003 active site 443149003004 catalytic site [active] 443149003005 metal binding site [ion binding]; metal-binding site 443149003006 fumarate hydratase; Reviewed; Region: fumC; PRK00485 443149003007 Class II fumarases; Region: Fumarase_classII; cd01362 443149003008 active site 443149003009 tetramer interface [polypeptide binding]; other site 443149003010 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 443149003011 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 443149003012 putative active site [active] 443149003013 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 443149003014 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 443149003015 Domain of unknown function DUF20; Region: UPF0118; pfam01594 443149003016 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 443149003017 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 443149003018 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 443149003019 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 443149003020 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 443149003021 3beta-hydroxysteroid dehydrogenases (3b-HSD)-like, extended (e) SDRs; Region: 3b-HSD-like_SDR_e; cd05241 443149003022 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 443149003023 putative NAD(P) binding site [chemical binding]; other site 443149003024 active site 443149003025 putative substrate binding site [chemical binding]; other site 443149003026 exodeoxyribonuclease VII, small subunit; Region: xseB; TIGR01280 443149003027 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 443149003028 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 443149003029 generic binding surface II; other site 443149003030 generic binding surface I; other site 443149003031 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 443149003032 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 443149003033 GTP-binding protein YchF; Reviewed; Region: PRK09601 443149003034 YchF GTPase; Region: YchF; cd01900 443149003035 G1 box; other site 443149003036 GTP/Mg2+ binding site [chemical binding]; other site 443149003037 Switch I region; other site 443149003038 G2 box; other site 443149003039 Switch II region; other site 443149003040 G3 box; other site 443149003041 G4 box; other site 443149003042 G5 box; other site 443149003043 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 443149003044 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 443149003045 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487 443149003046 putative active site [active] 443149003047 Uncharacterized conserved protein [Function unknown]; Region: COG1359 443149003048 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 443149003049 cyclase homology domain; Region: CHD; cd07302 443149003050 nucleotidyl binding site; other site 443149003051 metal binding site [ion binding]; metal-binding site 443149003052 dimer interface [polypeptide binding]; other site 443149003053 glucose-6-phosphate 1-dehydrogenase; Region: zwf; TIGR00871 443149003054 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 443149003055 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 443149003056 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 443149003057 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd_rel; TIGR00872 443149003058 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443149003059 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443149003060 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443149003061 pyruvate phosphate dikinase; Provisional; Region: PRK05878 443149003062 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 443149003063 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 443149003064 Domain of unknown function (DUF222); Region: DUF222; pfam02720 443149003065 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 443149003066 active site 443149003067 Domain of unknown function (DUF222); Region: DUF222; pfam02720 443149003068 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 443149003069 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443149003070 non-specific DNA binding site [nucleotide binding]; other site 443149003071 salt bridge; other site 443149003072 sequence-specific DNA binding site [nucleotide binding]; other site 443149003073 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 443149003074 Domain of unknown function (DUF955); Region: DUF955; pfam06114 443149003075 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 443149003076 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 443149003077 citrate synthase; Provisional; Region: PRK14033 443149003078 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 443149003079 oxalacetate binding site [chemical binding]; other site 443149003080 citrylCoA binding site [chemical binding]; other site 443149003081 coenzyme A binding site [chemical binding]; other site 443149003082 catalytic triad [active] 443149003083 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 443149003084 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 443149003085 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 443149003086 THF binding site; other site 443149003087 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 443149003088 substrate binding site [chemical binding]; other site 443149003089 THF binding site; other site 443149003090 zinc-binding site [ion binding]; other site 443149003091 putative transposase OrfB; Reviewed; Region: PHA02517 443149003092 HTH-like domain; Region: HTH_21; pfam13276 443149003093 Integrase core domain; Region: rve; pfam00665 443149003094 Integrase core domain; Region: rve_3; pfam13683 443149003095 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 443149003096 Transposase; Region: HTH_Tnp_1; cl17663 443149003097 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149003098 PPE family; Region: PPE; pfam00823 443149003099 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149003100 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 443149003101 active site 443149003102 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 443149003103 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443149003104 substrate binding site [chemical binding]; other site 443149003105 oxyanion hole (OAH) forming residues; other site 443149003106 enoyl-CoA hydratase; Provisional; Region: PRK06494 443149003107 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 443149003108 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 443149003109 CAAX protease self-immunity; Region: Abi; pfam02517 443149003110 enoyl-CoA hydratase; Provisional; Region: PRK06688 443149003111 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 443149003112 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443149003113 trimer interface [polypeptide binding]; other site 443149003114 enoyl-CoA hydratase; Provisional; Region: PRK06688 443149003115 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443149003116 substrate binding site [chemical binding]; other site 443149003117 oxyanion hole (OAH) forming residues; other site 443149003118 trimer interface [polypeptide binding]; other site 443149003119 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 443149003120 CoA-transferase family III; Region: CoA_transf_3; pfam02515 443149003121 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 443149003122 NAD binding site [chemical binding]; other site 443149003123 homodimer interface [polypeptide binding]; other site 443149003124 homotetramer interface [polypeptide binding]; other site 443149003125 active site 443149003126 MMPL family; Region: MMPL; pfam03176 443149003127 MMPL family; Region: MMPL; pfam03176 443149003128 DDE superfamily endonuclease; Region: DDE_5; cl17874 443149003129 Domain of unknown function (DUF222); Region: DUF222; pfam02720 443149003130 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 443149003131 active site 443149003132 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 443149003133 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 443149003134 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 443149003135 NAD-dependent deacetylase; Provisional; Region: PRK00481 443149003136 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 443149003137 NAD+ binding site [chemical binding]; other site 443149003138 substrate binding site [chemical binding]; other site 443149003139 Zn binding site [ion binding]; other site 443149003140 Predicted transcriptional regulators [Transcription]; Region: COG1725 443149003141 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443149003142 DNA-binding site [nucleotide binding]; DNA binding site 443149003143 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 443149003144 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 443149003145 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 443149003146 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 443149003147 uncharacterized HhH-GPD family protein; Region: TIGR03252 443149003148 minor groove reading motif; other site 443149003149 helix-hairpin-helix signature motif; other site 443149003150 mannosyltransferase; Provisional; Region: pimE; PRK13375 443149003151 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 443149003152 aromatic arch; other site 443149003153 DCoH dimer interaction site [polypeptide binding]; other site 443149003154 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 443149003155 DCoH tetramer interaction site [polypeptide binding]; other site 443149003156 substrate binding site [chemical binding]; other site 443149003157 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 443149003158 active site 443149003159 8-oxo-dGMP binding site [chemical binding]; other site 443149003160 nudix motif; other site 443149003161 metal binding site [ion binding]; metal-binding site 443149003162 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 443149003163 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 443149003164 [4Fe-4S] binding site [ion binding]; other site 443149003165 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 443149003166 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 443149003167 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 443149003168 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 443149003169 molybdopterin cofactor binding site; other site 443149003170 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 443149003171 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 443149003172 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 443149003173 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 443149003174 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 443149003175 G1 box; other site 443149003176 putative GEF interaction site [polypeptide binding]; other site 443149003177 GTP/Mg2+ binding site [chemical binding]; other site 443149003178 Switch I region; other site 443149003179 G2 box; other site 443149003180 G3 box; other site 443149003181 Switch II region; other site 443149003182 G4 box; other site 443149003183 G5 box; other site 443149003184 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 443149003185 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 443149003186 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 443149003187 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 443149003188 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 443149003189 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149003190 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149003191 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149003192 PPE family; Region: PPE; pfam00823 443149003193 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 443149003194 PE family; Region: PE; pfam00934 443149003195 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 443149003196 PE family; Region: PE; pfam00934 443149003197 FO synthase; Reviewed; Region: fbiC; PRK09234 443149003198 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443149003199 FeS/SAM binding site; other site 443149003200 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443149003201 FeS/SAM binding site; other site 443149003202 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 443149003203 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 443149003204 active site 443149003205 FMN binding site [chemical binding]; other site 443149003206 2,4-decadienoyl-CoA binding site; other site 443149003207 catalytic residue [active] 443149003208 4Fe-4S cluster binding site [ion binding]; other site 443149003209 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 443149003210 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443149003211 Predicted transcriptional regulators [Transcription]; Region: COG1695 443149003212 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 443149003213 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 443149003214 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 443149003215 4Fe-4S binding domain; Region: Fer4; pfam00037 443149003216 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 443149003217 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443149003218 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443149003219 homodimer interface [polypeptide binding]; other site 443149003220 catalytic residue [active] 443149003221 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 443149003222 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 443149003223 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 443149003224 ATP binding site [chemical binding]; other site 443149003225 putative Mg++ binding site [ion binding]; other site 443149003226 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 443149003227 ATP-binding site [chemical binding]; other site 443149003228 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 443149003229 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 443149003230 active site 443149003231 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 443149003232 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 443149003233 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443149003234 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 443149003235 Enoylreductase; Region: PKS_ER; smart00829 443149003236 NAD(P) binding site [chemical binding]; other site 443149003237 KR domain; Region: KR; pfam08659 443149003238 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 443149003239 putative NADP binding site [chemical binding]; other site 443149003240 active site 443149003241 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 443149003242 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 443149003243 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 443149003244 PE-PPE domain; Region: PE-PPE; pfam08237 443149003245 acyl-CoA synthetase; Validated; Region: PRK05850 443149003246 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 443149003247 acyl-activating enzyme (AAE) consensus motif; other site 443149003248 active site 443149003249 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 443149003250 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 443149003251 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 443149003252 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 443149003253 Glutamate binding site [chemical binding]; other site 443149003254 NAD binding site [chemical binding]; other site 443149003255 catalytic residues [active] 443149003256 Proline dehydrogenase; Region: Pro_dh; pfam01619 443149003257 RNA polymerase sigma factor SigI; Provisional; Region: sigI; PRK09635 443149003258 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443149003259 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443149003260 DNA binding residues [nucleotide binding] 443149003261 haloalkane dehalogenase; Provisional; Region: PRK03204 443149003262 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 443149003263 catalytic site [active] 443149003264 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443149003265 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 443149003266 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443149003267 PGAP1-like protein; Region: PGAP1; pfam07819 443149003268 acyl-CoA synthetase; Validated; Region: PRK07787 443149003269 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443149003270 acyl-activating enzyme (AAE) consensus motif; other site 443149003271 AMP binding site [chemical binding]; other site 443149003272 active site 443149003273 CoA binding site [chemical binding]; other site 443149003274 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 443149003275 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 443149003276 PE family; Region: PE; pfam00934 443149003277 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149003278 PPE family; Region: PPE; pfam00823 443149003279 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 443149003280 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 443149003281 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 443149003282 Transposase, Mutator family; Region: Transposase_mut; pfam00872 443149003283 MULE transposase domain; Region: MULE; pfam10551 443149003284 metabolite-proton symporter; Region: 2A0106; TIGR00883 443149003285 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443149003286 putative substrate translocation pore; other site 443149003287 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 443149003288 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 443149003289 putative trimer interface [polypeptide binding]; other site 443149003290 putative CoA binding site [chemical binding]; other site 443149003291 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 443149003292 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 443149003293 metal binding site [ion binding]; metal-binding site 443149003294 putative dimer interface [polypeptide binding]; other site 443149003295 TIGR00730 family protein; Region: TIGR00730 443149003296 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 443149003297 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 443149003298 acyl-activating enzyme (AAE) consensus motif; other site 443149003299 putative AMP binding site [chemical binding]; other site 443149003300 putative active site [active] 443149003301 putative CoA binding site [chemical binding]; other site 443149003302 dihydropteroate synthase; Region: DHPS; TIGR01496 443149003303 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 443149003304 substrate binding pocket [chemical binding]; other site 443149003305 dimer interface [polypeptide binding]; other site 443149003306 inhibitor binding site; inhibition site 443149003307 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 443149003308 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 443149003309 DivIVA domain; Region: DivI1A_domain; TIGR03544 443149003310 DNA-3-methyladenine glycosylase I; Region: tag; TIGR00624 443149003311 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 443149003312 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 443149003313 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 443149003314 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 443149003315 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 443149003316 ligand binding site; other site 443149003317 oligomer interface; other site 443149003318 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 443149003319 dimer interface [polypeptide binding]; other site 443149003320 N-terminal domain interface [polypeptide binding]; other site 443149003321 sulfate 1 binding site; other site 443149003322 PE family; Region: PE; pfam00934 443149003323 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 443149003324 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 443149003325 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 443149003326 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 443149003327 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 443149003328 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 443149003329 Walker A/P-loop; other site 443149003330 ATP binding site [chemical binding]; other site 443149003331 Q-loop/lid; other site 443149003332 ABC transporter signature motif; other site 443149003333 Walker B; other site 443149003334 D-loop; other site 443149003335 H-loop/switch region; other site 443149003336 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 443149003337 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149003338 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 443149003339 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149003340 S-adenosylmethionine binding site [chemical binding]; other site 443149003341 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 443149003342 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443149003343 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443149003344 DNA binding residues [nucleotide binding] 443149003345 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 443149003346 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 443149003347 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 443149003348 protein binding site [polypeptide binding]; other site 443149003349 sec-independent translocase; Provisional; Region: PRK03100 443149003350 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443149003351 Predicted membrane protein [Function unknown]; Region: COG3428 443149003352 Bacterial PH domain; Region: DUF304; pfam03703 443149003353 Uncharacterized conserved protein [Function unknown]; Region: COG3402 443149003354 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 443149003355 Domain of unknown function DUF59; Region: DUF59; cl00941 443149003356 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 443149003357 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 443149003358 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 443149003359 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 443149003360 N-acetyl-D-glucosamine binding site [chemical binding]; other site 443149003361 catalytic residue [active] 443149003362 Predicted membrane protein [Function unknown]; Region: COG4420 443149003363 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 443149003364 MgtE intracellular N domain; Region: MgtE_N; smart00924 443149003365 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 443149003366 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 443149003367 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 443149003368 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 443149003369 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443149003370 dimer interface [polypeptide binding]; other site 443149003371 conserved gate region; other site 443149003372 putative PBP binding loops; other site 443149003373 ABC-ATPase subunit interface; other site 443149003374 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 443149003375 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443149003376 dimer interface [polypeptide binding]; other site 443149003377 conserved gate region; other site 443149003378 ABC-ATPase subunit interface; other site 443149003379 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 443149003380 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 443149003381 Walker A/P-loop; other site 443149003382 ATP binding site [chemical binding]; other site 443149003383 Q-loop/lid; other site 443149003384 ABC transporter signature motif; other site 443149003385 Walker B; other site 443149003386 D-loop; other site 443149003387 H-loop/switch region; other site 443149003388 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 443149003389 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 443149003390 oligomer interface [polypeptide binding]; other site 443149003391 metal binding site [ion binding]; metal-binding site 443149003392 metal binding site [ion binding]; metal-binding site 443149003393 putative Cl binding site [ion binding]; other site 443149003394 basic sphincter; other site 443149003395 hydrophobic gate; other site 443149003396 periplasmic entrance; other site 443149003397 malate dehydrogenase; Provisional; Region: PRK05442 443149003398 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 443149003399 NAD(P) binding site [chemical binding]; other site 443149003400 dimer interface [polypeptide binding]; other site 443149003401 malate binding site [chemical binding]; other site 443149003402 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 443149003403 PE family; Region: PE; pfam00934 443149003404 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 443149003405 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 443149003406 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443149003407 NAD(P) binding site [chemical binding]; other site 443149003408 active site 443149003409 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 443149003410 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 443149003411 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 443149003412 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 443149003413 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 443149003414 TPP-binding site [chemical binding]; other site 443149003415 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 443149003416 dimer interface [polypeptide binding]; other site 443149003417 PYR/PP interface [polypeptide binding]; other site 443149003418 TPP binding site [chemical binding]; other site 443149003419 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 443149003420 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443149003421 putative substrate translocation pore; other site 443149003422 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443149003423 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 443149003424 RNase_H superfamily; Region: RNase_H_2; pfam13482 443149003425 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 443149003426 Part of AAA domain; Region: AAA_19; pfam13245 443149003427 AAA domain; Region: AAA_12; pfam13087 443149003428 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 443149003429 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 443149003430 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 443149003431 ATP binding site [chemical binding]; other site 443149003432 Mg++ binding site [ion binding]; other site 443149003433 motif III; other site 443149003434 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443149003435 nucleotide binding region [chemical binding]; other site 443149003436 ATP-binding site [chemical binding]; other site 443149003437 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 443149003438 putative RNA binding site [nucleotide binding]; other site 443149003439 Acyltransferase family; Region: Acyl_transf_3; pfam01757 443149003440 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149003441 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149003442 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443149003443 FAD binding domain; Region: FAD_binding_4; pfam01565 443149003444 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 443149003445 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443149003446 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443149003447 putative substrate translocation pore; other site 443149003448 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 443149003449 Fe-S cluster binding site [ion binding]; other site 443149003450 DNA binding site [nucleotide binding] 443149003451 active site 443149003452 hypothetical protein; Validated; Region: PRK05868 443149003453 hypothetical protein; Provisional; Region: PRK07236 443149003454 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 443149003455 Domain of unknown function (DUF385); Region: DUF385; pfam04075 443149003456 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 443149003457 HIT family signature motif; other site 443149003458 catalytic residue [active] 443149003459 amidase; Provisional; Region: PRK12470 443149003460 Amidase; Region: Amidase; pfam01425 443149003461 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 443149003462 cyclase homology domain; Region: CHD; cd07302 443149003463 nucleotidyl binding site; other site 443149003464 metal binding site [ion binding]; metal-binding site 443149003465 dimer interface [polypeptide binding]; other site 443149003466 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 443149003467 Catalytic domain of Protein Kinases; Region: PKc; cd00180 443149003468 active site 443149003469 ATP binding site [chemical binding]; other site 443149003470 substrate binding site [chemical binding]; other site 443149003471 activation loop (A-loop); other site 443149003472 PknH-like extracellular domain; Region: PknH_C; pfam14032 443149003473 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 443149003474 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 443149003475 DNA binding site [nucleotide binding] 443149003476 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 443149003477 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 443149003478 phosphopeptide binding site; other site 443149003479 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 443149003480 putative active site [active] 443149003481 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 443149003482 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 443149003483 Protein of unknown function (DUF732); Region: DUF732; pfam05305 443149003484 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 443149003485 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 443149003486 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 443149003487 Walker A/P-loop; other site 443149003488 ATP binding site [chemical binding]; other site 443149003489 Q-loop/lid; other site 443149003490 ABC transporter signature motif; other site 443149003491 Walker B; other site 443149003492 D-loop; other site 443149003493 H-loop/switch region; other site 443149003494 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 443149003495 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 443149003496 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443149003497 Walker A/P-loop; other site 443149003498 ATP binding site [chemical binding]; other site 443149003499 Q-loop/lid; other site 443149003500 ABC transporter signature motif; other site 443149003501 Walker B; other site 443149003502 D-loop; other site 443149003503 H-loop/switch region; other site 443149003504 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 443149003505 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 443149003506 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 443149003507 catalytic core [active] 443149003508 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 443149003509 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 443149003510 active site 443149003511 metal binding site [ion binding]; metal-binding site 443149003512 DNA binding site [nucleotide binding] 443149003513 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443149003514 Walker A/P-loop; other site 443149003515 ATP binding site [chemical binding]; other site 443149003516 choline dehydrogenase; Validated; Region: PRK02106 443149003517 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 443149003518 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 443149003519 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 443149003520 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 443149003521 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 443149003522 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 443149003523 Walker A/P-loop; other site 443149003524 ATP binding site [chemical binding]; other site 443149003525 Q-loop/lid; other site 443149003526 ABC transporter signature motif; other site 443149003527 Walker B; other site 443149003528 D-loop; other site 443149003529 H-loop/switch region; other site 443149003530 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 443149003531 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 443149003532 Walker A/P-loop; other site 443149003533 ATP binding site [chemical binding]; other site 443149003534 Q-loop/lid; other site 443149003535 ABC transporter signature motif; other site 443149003536 Walker B; other site 443149003537 D-loop; other site 443149003538 H-loop/switch region; other site 443149003539 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 443149003540 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 443149003541 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443149003542 dimer interface [polypeptide binding]; other site 443149003543 conserved gate region; other site 443149003544 putative PBP binding loops; other site 443149003545 ABC-ATPase subunit interface; other site 443149003546 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 443149003547 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443149003548 dimer interface [polypeptide binding]; other site 443149003549 conserved gate region; other site 443149003550 putative PBP binding loops; other site 443149003551 ABC-ATPase subunit interface; other site 443149003552 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 443149003553 active site clefts [active] 443149003554 zinc binding site [ion binding]; other site 443149003555 dimer interface [polypeptide binding]; other site 443149003556 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 443149003557 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 443149003558 Active Sites [active] 443149003559 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 443149003560 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 443149003561 CysD dimerization site [polypeptide binding]; other site 443149003562 G1 box; other site 443149003563 putative GEF interaction site [polypeptide binding]; other site 443149003564 GTP/Mg2+ binding site [chemical binding]; other site 443149003565 Switch I region; other site 443149003566 G2 box; other site 443149003567 G3 box; other site 443149003568 Switch II region; other site 443149003569 G4 box; other site 443149003570 G5 box; other site 443149003571 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 443149003572 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 443149003573 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443149003574 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 443149003575 Walker A/P-loop; other site 443149003576 ligand-binding site [chemical binding]; other site 443149003577 ATP binding site [chemical binding]; other site 443149003578 Rrf2 family protein; Region: rrf2_super; TIGR00738 443149003579 Transcriptional regulator; Region: Rrf2; pfam02082 443149003580 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 443149003581 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 443149003582 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 443149003583 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 443149003584 Putative esterase; Region: Esterase; pfam00756 443149003585 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 443149003586 Predicted membrane protein [Function unknown]; Region: COG4325 443149003587 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 443149003588 Protein of unknown function (DUF732); Region: DUF732; pfam05305 443149003589 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 443149003590 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 443149003591 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 443149003592 active site 443149003593 HIGH motif; other site 443149003594 KMSK motif region; other site 443149003595 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 443149003596 tRNA binding surface [nucleotide binding]; other site 443149003597 anticodon binding site; other site 443149003598 diaminopimelate decarboxylase; Region: lysA; TIGR01048 443149003599 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 443149003600 active site 443149003601 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 443149003602 substrate binding site [chemical binding]; other site 443149003603 catalytic residues [active] 443149003604 dimer interface [polypeptide binding]; other site 443149003605 homoserine dehydrogenase; Provisional; Region: PRK06349 443149003606 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 443149003607 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 443149003608 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 443149003609 threonine synthase; Reviewed; Region: PRK06721 443149003610 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 443149003611 homodimer interface [polypeptide binding]; other site 443149003612 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443149003613 catalytic residue [active] 443149003614 Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083 443149003615 transcription termination factor Rho; Provisional; Region: PRK12678 443149003616 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 443149003617 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 443149003618 RNA binding site [nucleotide binding]; other site 443149003619 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 443149003620 multimer interface [polypeptide binding]; other site 443149003621 Walker A motif; other site 443149003622 ATP binding site [chemical binding]; other site 443149003623 Walker B motif; other site 443149003624 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 443149003625 peptide chain release factor 1; Region: prfA; TIGR00019 443149003626 This domain is found in peptide chain release factors; Region: PCRF; smart00937 443149003627 RF-1 domain; Region: RF-1; pfam00472 443149003628 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 443149003629 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149003630 S-adenosylmethionine binding site [chemical binding]; other site 443149003631 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 443149003632 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 443149003633 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 443149003634 Mg++ binding site [ion binding]; other site 443149003635 putative catalytic motif [active] 443149003636 substrate binding site [chemical binding]; other site 443149003637 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 443149003638 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 443149003639 F0F1 ATP synthase subunit C; Validated; Region: PRK05880 443149003640 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 443149003641 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 443149003642 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13428 443149003643 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 443149003644 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 443149003645 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 443149003646 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 443149003647 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 443149003648 Walker A motif; other site 443149003649 ATP binding site [chemical binding]; other site 443149003650 Walker B motif; other site 443149003651 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 443149003652 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 443149003653 core domain interface [polypeptide binding]; other site 443149003654 delta subunit interface [polypeptide binding]; other site 443149003655 epsilon subunit interface [polypeptide binding]; other site 443149003656 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 443149003657 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 443149003658 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 443149003659 alpha subunit interaction interface [polypeptide binding]; other site 443149003660 Walker A motif; other site 443149003661 ATP binding site [chemical binding]; other site 443149003662 Walker B motif; other site 443149003663 inhibitor binding site; inhibition site 443149003664 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 443149003665 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 443149003666 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 443149003667 gamma subunit interface [polypeptide binding]; other site 443149003668 epsilon subunit interface [polypeptide binding]; other site 443149003669 LBP interface [polypeptide binding]; other site 443149003670 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 443149003671 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 443149003672 Transposase; Region: DDE_Tnp_ISL3; pfam01610 443149003673 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 443149003674 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 443149003675 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 443149003676 hinge; other site 443149003677 active site 443149003678 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 443149003679 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 443149003680 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 443149003681 DNA binding site [nucleotide binding] 443149003682 active site 443149003683 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 443149003684 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 443149003685 AlkA N-terminal domain; Region: AlkA_N; pfam06029 443149003686 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 443149003687 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 443149003688 minor groove reading motif; other site 443149003689 helix-hairpin-helix signature motif; other site 443149003690 substrate binding pocket [chemical binding]; other site 443149003691 active site 443149003692 HAMP domain; Region: HAMP; pfam00672 443149003693 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 443149003694 cyclase homology domain; Region: CHD; cd07302 443149003695 nucleotidyl binding site; other site 443149003696 metal binding site [ion binding]; metal-binding site 443149003697 dimer interface [polypeptide binding]; other site 443149003698 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443149003699 dimerization interface [polypeptide binding]; other site 443149003700 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 443149003701 cyclase homology domain; Region: CHD; cd07302 443149003702 nucleotidyl binding site; other site 443149003703 metal binding site [ion binding]; metal-binding site 443149003704 dimer interface [polypeptide binding]; other site 443149003705 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443149003706 dimerization interface [polypeptide binding]; other site 443149003707 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 443149003708 cyclase homology domain; Region: CHD; cd07302 443149003709 nucleotidyl binding site; other site 443149003710 metal binding site [ion binding]; metal-binding site 443149003711 dimer interface [polypeptide binding]; other site 443149003712 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 443149003713 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443149003714 dimerization interface [polypeptide binding]; other site 443149003715 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 443149003716 cyclase homology domain; Region: CHD; cd07302 443149003717 nucleotidyl binding site; other site 443149003718 metal binding site [ion binding]; metal-binding site 443149003719 dimer interface [polypeptide binding]; other site 443149003720 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 443149003721 hypothetical protein; Provisional; Region: PRK03298 443149003722 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443149003723 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 443149003724 dimer interface [polypeptide binding]; other site 443149003725 substrate binding site [chemical binding]; other site 443149003726 metal binding site [ion binding]; metal-binding site 443149003727 putative acyltransferase; Provisional; Region: PRK05790 443149003728 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 443149003729 dimer interface [polypeptide binding]; other site 443149003730 active site 443149003731 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 443149003732 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 443149003733 PE family; Region: PE; pfam00934 443149003734 glycogen branching enzyme; Provisional; Region: PRK05402 443149003735 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 443149003736 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 443149003737 active site 443149003738 catalytic site [active] 443149003739 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 443149003740 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 443149003741 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 443149003742 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 443149003743 active site 443149003744 homodimer interface [polypeptide binding]; other site 443149003745 catalytic site [active] 443149003746 acceptor binding site [chemical binding]; other site 443149003747 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 443149003748 putative homodimer interface [polypeptide binding]; other site 443149003749 putative active site pocket [active] 443149003750 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 443149003751 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 443149003752 DEAD/DEAH box helicase; Region: DEAD; pfam00270 443149003753 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 443149003754 putative Mg++ binding site [ion binding]; other site 443149003755 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 443149003756 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 443149003757 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 443149003758 active site 443149003759 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 443149003760 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 443149003761 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 443149003762 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 443149003763 putative active site pocket [active] 443149003764 cleavage site 443149003765 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 443149003766 MPN+ (JAMM) motif; other site 443149003767 Zinc-binding site [ion binding]; other site 443149003768 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 443149003769 MoaE interaction surface [polypeptide binding]; other site 443149003770 MoeB interaction surface [polypeptide binding]; other site 443149003771 thiocarboxylated glycine; other site 443149003772 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 443149003773 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 443149003774 dimer interface [polypeptide binding]; other site 443149003775 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443149003776 catalytic residue [active] 443149003777 Rhomboid family; Region: Rhomboid; pfam01694 443149003778 glutamate racemase; Provisional; Region: PRK00865 443149003779 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 443149003780 ribonuclease PH; Reviewed; Region: rph; PRK00173 443149003781 Ribonuclease PH; Region: RNase_PH_bact; cd11362 443149003782 hexamer interface [polypeptide binding]; other site 443149003783 active site 443149003784 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 443149003785 active site 443149003786 dimerization interface [polypeptide binding]; other site 443149003787 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 443149003788 Glucitol operon activator [Transcription]; Region: GutM; COG4578 443149003789 acyl carrier protein; Validated; Region: PRK05883 443149003790 long-chain-fatty-acid--[acyl-carrier-protein] ligase; Validated; Region: PRK05851 443149003791 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 443149003792 acyl-activating enzyme (AAE) consensus motif; other site 443149003793 active site 443149003794 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149003795 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443149003796 active site 443149003797 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 443149003798 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 443149003799 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 443149003800 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 443149003801 FAD binding pocket [chemical binding]; other site 443149003802 FAD binding motif [chemical binding]; other site 443149003803 phosphate binding motif [ion binding]; other site 443149003804 NAD binding pocket [chemical binding]; other site 443149003805 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443149003806 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 443149003807 Walker A/P-loop; other site 443149003808 ATP binding site [chemical binding]; other site 443149003809 Q-loop/lid; other site 443149003810 ABC transporter signature motif; other site 443149003811 Walker B; other site 443149003812 D-loop; other site 443149003813 H-loop/switch region; other site 443149003814 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443149003815 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 443149003816 Walker A/P-loop; other site 443149003817 ATP binding site [chemical binding]; other site 443149003818 Q-loop/lid; other site 443149003819 ABC transporter signature motif; other site 443149003820 Walker B; other site 443149003821 D-loop; other site 443149003822 H-loop/switch region; other site 443149003823 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 443149003824 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443149003825 NAD(P) binding site [chemical binding]; other site 443149003826 active site 443149003827 tetracycline repressor protein TetR; Provisional; Region: PRK13756 443149003828 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149003829 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 443149003830 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 443149003831 GAF domain; Region: GAF; pfam01590 443149003832 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 443149003833 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 443149003834 metal binding site [ion binding]; metal-binding site 443149003835 active site 443149003836 I-site; other site 443149003837 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 443149003838 hypothetical protein; Provisional; Region: PRK07877 443149003839 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 443149003840 ATP binding site [chemical binding]; other site 443149003841 substrate interface [chemical binding]; other site 443149003842 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 443149003843 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 443149003844 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 443149003845 cyclase homology domain; Region: CHD; cd07302 443149003846 nucleotidyl binding site; other site 443149003847 dimer interface [polypeptide binding]; other site 443149003848 metal binding site [ion binding]; metal-binding site 443149003849 AAA ATPase domain; Region: AAA_16; pfam13191 443149003850 Predicted ATPase [General function prediction only]; Region: COG3903 443149003851 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443149003852 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443149003853 DNA binding residues [nucleotide binding] 443149003854 dimerization interface [polypeptide binding]; other site 443149003855 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 443149003856 cyclase homology domain; Region: CHD; cd07302 443149003857 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 443149003858 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 443149003859 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149003860 PPE family; Region: PPE; pfam00823 443149003861 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 443149003862 PAS fold; Region: PAS_4; pfam08448 443149003863 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443149003864 putative active site [active] 443149003865 heme pocket [chemical binding]; other site 443149003866 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 443149003867 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 443149003868 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 443149003869 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 443149003870 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 443149003871 anti sigma factor interaction site; other site 443149003872 regulatory phosphorylation site [posttranslational modification]; other site 443149003873 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 443149003874 anti sigma factor interaction site; other site 443149003875 regulatory phosphorylation site [posttranslational modification]; other site 443149003876 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 443149003877 synthetase active site [active] 443149003878 NTP binding site [chemical binding]; other site 443149003879 metal binding site [ion binding]; metal-binding site 443149003880 Beta-lactamase; Region: Beta-lactamase; pfam00144 443149003881 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 443149003882 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 443149003883 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; pfam00173 443149003884 putative transposase OrfB; Reviewed; Region: PHA02517 443149003885 HTH-like domain; Region: HTH_21; pfam13276 443149003886 Integrase core domain; Region: rve; pfam00665 443149003887 Integrase core domain; Region: rve_3; pfam13683 443149003888 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 443149003889 Transposase; Region: HTH_Tnp_1; cl17663 443149003890 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 443149003891 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 443149003892 malonyl-CoA binding site [chemical binding]; other site 443149003893 dimer interface [polypeptide binding]; other site 443149003894 active site 443149003895 product binding site; other site 443149003896 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 443149003897 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 443149003898 uncharacterized domain; Region: TIGR00702 443149003899 YcaO-like family; Region: YcaO; pfam02624 443149003900 Uncharacterized conserved protein [Function unknown]; Region: COG3482 443149003901 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149003902 S-adenosylmethionine binding site [chemical binding]; other site 443149003903 Domain of unknown function (DUF222); Region: DUF222; pfam02720 443149003904 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 443149003905 active site 443149003906 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 443149003907 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 443149003908 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 443149003909 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 443149003910 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 443149003911 dihydroorotase; Validated; Region: pyrC; PRK09357 443149003912 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 443149003913 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 443149003914 active site 443149003915 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 443149003916 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 443149003917 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 443149003918 catalytic site [active] 443149003919 subunit interface [polypeptide binding]; other site 443149003920 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 443149003921 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 443149003922 ATP-grasp domain; Region: ATP-grasp_4; cl17255 443149003923 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 443149003924 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 443149003925 ATP-grasp domain; Region: ATP-grasp_4; cl17255 443149003926 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 443149003927 IMP binding site; other site 443149003928 dimer interface [polypeptide binding]; other site 443149003929 interdomain contacts; other site 443149003930 partial ornithine binding site; other site 443149003931 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 443149003932 active site 443149003933 dimer interface [polypeptide binding]; other site 443149003934 PE family; Region: PE; pfam00934 443149003935 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149003936 PPE family; Region: PPE; pfam00823 443149003937 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 443149003938 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 443149003939 catalytic site [active] 443149003940 G-X2-G-X-G-K; other site 443149003941 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 443149003942 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 443149003943 Flavoprotein; Region: Flavoprotein; pfam02441 443149003944 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 443149003945 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 443149003946 S-adenosylmethionine synthetase; Validated; Region: PRK05250 443149003947 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 443149003948 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 443149003949 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 443149003950 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 443149003951 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443149003952 Cytochrome P450; Region: p450; cl12078 443149003953 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 443149003954 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 443149003955 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 443149003956 PE family; Region: PE; pfam00934 443149003957 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 443149003958 oligomeric interface; other site 443149003959 putative active site [active] 443149003960 homodimer interface [polypeptide binding]; other site 443149003961 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 443149003962 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 443149003963 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 443149003964 substrate binding pocket [chemical binding]; other site 443149003965 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 443149003966 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 443149003967 substrate binding pocket [chemical binding]; other site 443149003968 Predicted membrane protein [Function unknown]; Region: COG3714 443149003969 primosome assembly protein PriA; Provisional; Region: PRK14873 443149003970 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149003971 S-adenosylmethionine binding site [chemical binding]; other site 443149003972 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 443149003973 MarR family; Region: MarR; pfam01047 443149003974 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149003975 S-adenosylmethionine binding site [chemical binding]; other site 443149003976 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 443149003977 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 443149003978 putative active site [active] 443149003979 substrate binding site [chemical binding]; other site 443149003980 putative cosubstrate binding site; other site 443149003981 catalytic site [active] 443149003982 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 443149003983 substrate binding site [chemical binding]; other site 443149003984 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 443149003985 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 443149003986 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 443149003987 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 443149003988 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 443149003989 substrate binding site [chemical binding]; other site 443149003990 hexamer interface [polypeptide binding]; other site 443149003991 metal binding site [ion binding]; metal-binding site 443149003992 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 443149003993 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 443149003994 catalytic motif [active] 443149003995 Zn binding site [ion binding]; other site 443149003996 RibD C-terminal domain; Region: RibD_C; pfam01872 443149003997 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 443149003998 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443149003999 putative substrate translocation pore; other site 443149004000 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 443149004001 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 443149004002 Lumazine binding domain; Region: Lum_binding; pfam00677 443149004003 Lumazine binding domain; Region: Lum_binding; pfam00677 443149004004 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 443149004005 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 443149004006 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 443149004007 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 443149004008 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 443149004009 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 443149004010 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 443149004011 dimerization interface [polypeptide binding]; other site 443149004012 active site 443149004013 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 443149004014 homopentamer interface [polypeptide binding]; other site 443149004015 active site 443149004016 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 443149004017 PknH-like extracellular domain; Region: PknH_C; pfam14032 443149004018 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 443149004019 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 443149004020 putative sugar binding sites [chemical binding]; other site 443149004021 Q-X-W motif; other site 443149004022 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 443149004023 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 443149004024 GIY-YIG motif/motif A; other site 443149004025 active site 443149004026 catalytic site [active] 443149004027 putative DNA binding site [nucleotide binding]; other site 443149004028 metal binding site [ion binding]; metal-binding site 443149004029 UvrB/uvrC motif; Region: UVR; pfam02151 443149004030 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 443149004031 Helix-hairpin-helix motif; Region: HHH; pfam00633 443149004032 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 443149004033 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 443149004034 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 443149004035 phosphate binding site [ion binding]; other site 443149004036 putative substrate binding pocket [chemical binding]; other site 443149004037 dimer interface [polypeptide binding]; other site 443149004038 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 443149004039 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 443149004040 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443149004041 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443149004042 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 443149004043 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 443149004044 acyl-CoA synthetase; Provisional; Region: PRK13382 443149004045 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 443149004046 acyl-activating enzyme (AAE) consensus motif; other site 443149004047 putative AMP binding site [chemical binding]; other site 443149004048 putative active site [active] 443149004049 putative CoA binding site [chemical binding]; other site 443149004050 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 443149004051 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 443149004052 putative acyl-acceptor binding pocket; other site 443149004053 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 443149004054 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 443149004055 PE family; Region: PE; pfam00934 443149004056 PE-PPE domain; Region: PE-PPE; pfam08237 443149004057 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 443149004058 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 443149004059 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 443149004060 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 443149004061 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 443149004062 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 443149004063 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 443149004064 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 443149004065 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 443149004066 Phosphoglycerate kinase; Region: PGK; pfam00162 443149004067 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 443149004068 substrate binding site [chemical binding]; other site 443149004069 hinge regions; other site 443149004070 ADP binding site [chemical binding]; other site 443149004071 catalytic site [active] 443149004072 triosephosphate isomerase; Provisional; Region: PRK14567 443149004073 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 443149004074 substrate binding site [chemical binding]; other site 443149004075 dimer interface [polypeptide binding]; other site 443149004076 catalytic triad [active] 443149004077 SnoaL-like domain; Region: SnoaL_2; pfam12680 443149004078 Preprotein translocase SecG subunit; Region: SecG; cl09123 443149004079 PE family; Region: PE; pfam00934 443149004080 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 443149004081 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 443149004082 molybdopterin cofactor binding site [chemical binding]; other site 443149004083 substrate binding site [chemical binding]; other site 443149004084 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 443149004085 molybdopterin cofactor binding site; other site 443149004086 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 443149004087 hydrophobic ligand binding site; other site 443149004088 Proteins of 100 residues with WXG; Region: WXG100; cl02005 443149004089 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 443149004090 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 443149004091 putative active site [active] 443149004092 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 443149004093 Glucose-6-P dehydrogenase subunit [Carbohydrate transport and metabolism]; Region: COG3429 443149004094 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 443149004095 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 443149004096 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 443149004097 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 443149004098 putative active site [active] 443149004099 transaldolase; Provisional; Region: PRK03903 443149004100 catalytic residue [active] 443149004101 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 443149004102 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 443149004103 TPP-binding site [chemical binding]; other site 443149004104 dimer interface [polypeptide binding]; other site 443149004105 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 443149004106 PYR/PP interface [polypeptide binding]; other site 443149004107 dimer interface [polypeptide binding]; other site 443149004108 TPP binding site [chemical binding]; other site 443149004109 PE family; Region: PE; pfam00934 443149004110 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 443149004111 UbiA prenyltransferase family; Region: UbiA; pfam01040 443149004112 PE family; Region: PE; pfam00934 443149004113 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 443149004114 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 443149004115 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 443149004116 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 443149004117 NADP binding site [chemical binding]; other site 443149004118 dimer interface [polypeptide binding]; other site 443149004119 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 443149004120 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 443149004121 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 443149004122 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 443149004123 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 443149004124 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 443149004125 Walker A/P-loop; other site 443149004126 ATP binding site [chemical binding]; other site 443149004127 Q-loop/lid; other site 443149004128 ABC transporter signature motif; other site 443149004129 Walker B; other site 443149004130 D-loop; other site 443149004131 H-loop/switch region; other site 443149004132 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 443149004133 Predicted transcriptional regulator [Transcription]; Region: COG2345 443149004134 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443149004135 putative DNA binding site [nucleotide binding]; other site 443149004136 putative Zn2+ binding site [ion binding]; other site 443149004137 Transcriptional regulator PadR-like family; Region: PadR; cl17335 443149004138 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 443149004139 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 443149004140 protein-splicing catalytic site; other site 443149004141 thioester formation/cholesterol transfer; other site 443149004142 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 443149004143 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 443149004144 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 443149004145 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 443149004146 FeS assembly protein SufD; Region: sufD; TIGR01981 443149004147 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 443149004148 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 443149004149 Walker A/P-loop; other site 443149004150 ATP binding site [chemical binding]; other site 443149004151 Q-loop/lid; other site 443149004152 ABC transporter signature motif; other site 443149004153 Walker B; other site 443149004154 D-loop; other site 443149004155 H-loop/switch region; other site 443149004156 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 443149004157 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 443149004158 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443149004159 catalytic residue [active] 443149004160 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 443149004161 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 443149004162 trimerization site [polypeptide binding]; other site 443149004163 active site 443149004164 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 443149004165 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 443149004166 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 443149004167 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443149004168 active site 443149004169 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 443149004170 PE family; Region: PE; pfam00934 443149004171 putative transposase OrfB; Reviewed; Region: PHA02517 443149004172 HTH-like domain; Region: HTH_21; pfam13276 443149004173 Integrase core domain; Region: rve; pfam00665 443149004174 Integrase core domain; Region: rve_3; pfam13683 443149004175 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 443149004176 Transposase; Region: HTH_Tnp_1; cl17663 443149004177 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 443149004178 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 443149004179 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 443149004180 catalytic residues [active] 443149004181 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 443149004182 catalytic residues [active] 443149004183 enoyl-CoA hydratase; Provisional; Region: PRK05864 443149004184 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443149004185 substrate binding site [chemical binding]; other site 443149004186 oxyanion hole (OAH) forming residues; other site 443149004187 trimer interface [polypeptide binding]; other site 443149004188 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 443149004189 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443149004190 Walker A/P-loop; other site 443149004191 ATP binding site [chemical binding]; other site 443149004192 Q-loop/lid; other site 443149004193 ABC transporter signature motif; other site 443149004194 Walker B; other site 443149004195 D-loop; other site 443149004196 H-loop/switch region; other site 443149004197 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 443149004198 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149004199 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149004200 aconitate hydratase; Validated; Region: PRK09277 443149004201 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 443149004202 substrate binding site [chemical binding]; other site 443149004203 ligand binding site [chemical binding]; other site 443149004204 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 443149004205 substrate binding site [chemical binding]; other site 443149004206 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 443149004207 NlpC/P60 family; Region: NLPC_P60; pfam00877 443149004208 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 443149004209 NlpC/P60 family; Region: NLPC_P60; pfam00877 443149004210 MoxR-like ATPases [General function prediction only]; Region: COG0714 443149004211 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443149004212 Walker A motif; other site 443149004213 ATP binding site [chemical binding]; other site 443149004214 Walker B motif; other site 443149004215 arginine finger; other site 443149004216 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 443149004217 Protein of unknown function DUF58; Region: DUF58; pfam01882 443149004218 hypothetical protein; Provisional; Region: PRK13685 443149004219 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 443149004220 metal ion-dependent adhesion site (MIDAS); other site 443149004221 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 443149004222 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 443149004223 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 443149004224 NAD(P) binding site [chemical binding]; other site 443149004225 homotetramer interface [polypeptide binding]; other site 443149004226 homodimer interface [polypeptide binding]; other site 443149004227 active site 443149004228 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 443149004229 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 443149004230 NAD binding site [chemical binding]; other site 443149004231 homotetramer interface [polypeptide binding]; other site 443149004232 homodimer interface [polypeptide binding]; other site 443149004233 substrate binding site [chemical binding]; other site 443149004234 active site 443149004235 ferrochelatase; Reviewed; Region: hemH; PRK00035 443149004236 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 443149004237 C-terminal domain interface [polypeptide binding]; other site 443149004238 active site 443149004239 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 443149004240 active site 443149004241 N-terminal domain interface [polypeptide binding]; other site 443149004242 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 443149004243 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 443149004244 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 443149004245 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 443149004246 Uncharacterized conserved protein [Function unknown]; Region: COG0398 443149004247 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 443149004248 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 443149004249 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 443149004250 heterodimer interface [polypeptide binding]; other site 443149004251 substrate interaction site [chemical binding]; other site 443149004252 Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding) [Lipid metabolism]; Region: Sbm; COG2185 443149004253 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 443149004254 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 443149004255 active site 443149004256 substrate binding site [chemical binding]; other site 443149004257 coenzyme B12 binding site [chemical binding]; other site 443149004258 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 443149004259 B12 binding site [chemical binding]; other site 443149004260 cobalt ligand [ion binding]; other site 443149004261 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 443149004262 membrane ATPase/protein kinase; Provisional; Region: PRK09435 443149004263 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 443149004264 Walker A; other site 443149004265 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 443149004266 Beta-lactamase; Region: Beta-lactamase; pfam00144 443149004267 Methyltransferase domain; Region: Methyltransf_31; pfam13847 443149004268 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149004269 S-adenosylmethionine binding site [chemical binding]; other site 443149004270 Uncharacterized conserved protein [Function unknown]; Region: COG3360 443149004271 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 443149004272 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 443149004273 Ligand binding site; other site 443149004274 Putative Catalytic site; other site 443149004275 DXD motif; other site 443149004276 Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5285 443149004277 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 443149004278 active site 443149004279 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 443149004280 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 443149004281 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 443149004282 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 443149004283 inhibitor-cofactor binding pocket; inhibition site 443149004284 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443149004285 catalytic residue [active] 443149004286 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 443149004287 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 443149004288 putative trimer interface [polypeptide binding]; other site 443149004289 putative CoA binding site [chemical binding]; other site 443149004290 Methyltransferase domain; Region: Methyltransf_12; pfam08242 443149004291 S-adenosylmethionine binding site [chemical binding]; other site 443149004292 WbqC-like protein family; Region: WbqC; pfam08889 443149004293 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 443149004294 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443149004295 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443149004296 Methyltransferase domain; Region: Methyltransf_23; pfam13489 443149004297 Methyltransferase domain; Region: Methyltransf_12; pfam08242 443149004298 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 443149004299 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 443149004300 NADP-binding site; other site 443149004301 homotetramer interface [polypeptide binding]; other site 443149004302 substrate binding site [chemical binding]; other site 443149004303 homodimer interface [polypeptide binding]; other site 443149004304 active site 443149004305 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 443149004306 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 443149004307 NADP binding site [chemical binding]; other site 443149004308 active site 443149004309 putative substrate binding site [chemical binding]; other site 443149004310 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 443149004311 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 443149004312 metal-binding site 443149004313 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149004314 S-adenosylmethionine binding site [chemical binding]; other site 443149004315 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 443149004316 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 443149004317 active site 443149004318 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 443149004319 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 443149004320 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 443149004321 active site 443149004322 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 443149004323 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 443149004324 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 443149004325 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 443149004326 active site 443149004327 acyl-CoA synthetase; Validated; Region: PRK05850 443149004328 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 443149004329 acyl-activating enzyme (AAE) consensus motif; other site 443149004330 active site 443149004331 Transport protein; Region: actII; TIGR00833 443149004332 Methyltransferase domain; Region: Methyltransf_23; pfam13489 443149004333 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149004334 S-adenosylmethionine binding site [chemical binding]; other site 443149004335 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 443149004336 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 443149004337 homodimer interface [polypeptide binding]; other site 443149004338 active site 443149004339 TDP-binding site; other site 443149004340 acceptor substrate-binding pocket; other site 443149004341 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 443149004342 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 443149004343 Probable Catalytic site; other site 443149004344 metal-binding site 443149004345 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 443149004346 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 443149004347 homodimer interface [polypeptide binding]; other site 443149004348 active site 443149004349 TDP-binding site; other site 443149004350 acceptor substrate-binding pocket; other site 443149004351 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 443149004352 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 443149004353 active site 443149004354 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 443149004355 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 443149004356 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443149004357 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 443149004358 Enoylreductase; Region: PKS_ER; smart00829 443149004359 NAD(P) binding site [chemical binding]; other site 443149004360 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 443149004361 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 443149004362 putative NADP binding site [chemical binding]; other site 443149004363 active site 443149004364 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 443149004365 acyl-CoA synthetase; Validated; Region: PRK05850 443149004366 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 443149004367 acyl-activating enzyme (AAE) consensus motif; other site 443149004368 active site 443149004369 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 443149004370 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 443149004371 NAD(P) binding site [chemical binding]; other site 443149004372 Uncharacterized conserved protein [Function unknown]; Region: COG2128 443149004373 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 443149004374 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 443149004375 CoenzymeA binding site [chemical binding]; other site 443149004376 subunit interaction site [polypeptide binding]; other site 443149004377 PHB binding site; other site 443149004378 Nitronate monooxygenase; Region: NMO; pfam03060 443149004379 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 443149004380 FMN binding site [chemical binding]; other site 443149004381 substrate binding site [chemical binding]; other site 443149004382 putative catalytic residue [active] 443149004383 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149004384 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 443149004385 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 443149004386 HIGH motif; other site 443149004387 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 443149004388 active site 443149004389 KMSKS motif; other site 443149004390 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 443149004391 tRNA binding surface [nucleotide binding]; other site 443149004392 anticodon binding site; other site 443149004393 DNA polymerase IV; Provisional; Region: PRK03348 443149004394 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 443149004395 active site 443149004396 DNA binding site [nucleotide binding] 443149004397 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 443149004398 active site 443149004399 homodimer interface [polypeptide binding]; other site 443149004400 homotetramer interface [polypeptide binding]; other site 443149004401 lipoprotein signal peptidase; Provisional; Region: PRK14764 443149004402 lipoprotein signal peptidase; Provisional; Region: PRK14787 443149004403 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 443149004404 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 443149004405 active site 443149004406 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 443149004407 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 443149004408 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 443149004409 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 443149004410 apolar tunnel; other site 443149004411 heme binding site [chemical binding]; other site 443149004412 dimerization interface [polypeptide binding]; other site 443149004413 short chain dehydrogenase; Provisional; Region: PRK05866 443149004414 classical (c) SDRs; Region: SDR_c; cd05233 443149004415 NAD(P) binding site [chemical binding]; other site 443149004416 active site 443149004417 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 443149004418 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443149004419 NAD(P) binding site [chemical binding]; other site 443149004420 active site 443149004421 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 443149004422 hydrophobic ligand binding site; other site 443149004423 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 443149004424 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 443149004425 active site 443149004426 PHP Thumb interface [polypeptide binding]; other site 443149004427 metal binding site [ion binding]; metal-binding site 443149004428 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 443149004429 generic binding surface II; other site 443149004430 generic binding surface I; other site 443149004431 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149004432 PPE family; Region: PPE; pfam00823 443149004433 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149004434 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149004435 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443149004436 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 443149004437 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 443149004438 acyl-activating enzyme (AAE) consensus motif; other site 443149004439 putative AMP binding site [chemical binding]; other site 443149004440 putative active site [active] 443149004441 putative CoA binding site [chemical binding]; other site 443149004442 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 443149004443 putative acyl-acceptor binding pocket; other site 443149004444 glycerol-3-phosphate acyltransferase; Reviewed; Region: PRK11915 443149004445 fumarate reductase, flavoprotein subunit; Region: fum_red_Fp; TIGR01176 443149004446 L-aspartate oxidase; Provisional; Region: PRK06175 443149004447 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 443149004448 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 443149004449 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 443149004450 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 443149004451 D-subunit interface [polypeptide binding]; other site 443149004452 Iron-sulfur protein interface; other site 443149004453 proximal quinone binding site [chemical binding]; other site 443149004454 distal quinone binding site [chemical binding]; other site 443149004455 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 443149004456 Iron-sulfur protein interface; other site 443149004457 proximal quinone binding site [chemical binding]; other site 443149004458 C-subunit interface; other site 443149004459 distal quinone binding site; other site 443149004460 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149004461 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149004462 MMPL family; Region: MMPL; pfam03176 443149004463 Domain of unknown function (DUF385); Region: DUF385; pfam04075 443149004464 threonine dehydratase; Validated; Region: PRK08639 443149004465 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 443149004466 tetramer interface [polypeptide binding]; other site 443149004467 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443149004468 catalytic residue [active] 443149004469 C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585 443149004470 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 443149004471 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 443149004472 putative active site [active] 443149004473 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 443149004474 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 443149004475 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 443149004476 catalytic site [active] 443149004477 active site 443149004478 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 443149004479 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 443149004480 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 443149004481 active site 443149004482 catalytic site [active] 443149004483 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 443149004484 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 443149004485 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 443149004486 active site 443149004487 catalytic site [active] 443149004488 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 443149004489 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 443149004490 NlpC/P60 family; Region: NLPC_P60; pfam00877 443149004491 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 443149004492 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 443149004493 inhibitor-cofactor binding pocket; inhibition site 443149004494 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443149004495 catalytic residue [active] 443149004496 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 443149004497 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 443149004498 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443149004499 catalytic residue [active] 443149004500 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 443149004501 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 443149004502 Domain of unknown function (DUF222); Region: DUF222; pfam02720 443149004503 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 443149004504 active site 443149004505 Domain of unknown function (DUF222); Region: DUF222; pfam02720 443149004506 biotin synthase; Validated; Region: PRK06256 443149004507 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443149004508 FeS/SAM binding site; other site 443149004509 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 443149004510 Protein of unknown function (DUF2567); Region: DUF2567; pfam10821 443149004511 Secretory lipase; Region: LIP; pfam03583 443149004512 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 443149004513 nudix motif; other site 443149004514 quinolinate synthetase; Provisional; Region: PRK09375 443149004515 L-aspartate oxidase; Provisional; Region: PRK07804 443149004516 L-aspartate oxidase; Provisional; Region: PRK06175 443149004517 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 443149004518 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 443149004519 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 443149004520 dimerization interface [polypeptide binding]; other site 443149004521 active site 443149004522 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149004523 S-adenosylmethionine binding site [chemical binding]; other site 443149004524 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 443149004525 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 443149004526 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 443149004527 NAD binding site [chemical binding]; other site 443149004528 dimerization interface [polypeptide binding]; other site 443149004529 product binding site; other site 443149004530 substrate binding site [chemical binding]; other site 443149004531 zinc binding site [ion binding]; other site 443149004532 catalytic residues [active] 443149004533 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 443149004534 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443149004535 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443149004536 homodimer interface [polypeptide binding]; other site 443149004537 catalytic residue [active] 443149004538 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 443149004539 4-fold oligomerization interface [polypeptide binding]; other site 443149004540 putative active site pocket [active] 443149004541 metal binding residues [ion binding]; metal-binding site 443149004542 3-fold/trimer interface [polypeptide binding]; other site 443149004543 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 443149004544 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 443149004545 putative active site [active] 443149004546 oxyanion strand; other site 443149004547 catalytic triad [active] 443149004548 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 443149004549 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 443149004550 catalytic residues [active] 443149004551 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 443149004552 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 443149004553 active site 443149004554 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 443149004555 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 443149004556 substrate binding site [chemical binding]; other site 443149004557 glutamase interaction surface [polypeptide binding]; other site 443149004558 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 443149004559 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 443149004560 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 443149004561 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 443149004562 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 443149004563 catalytic triad [active] 443149004564 anthranilate synthase component I; Provisional; Region: PRK13571 443149004565 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 443149004566 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 443149004567 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 443149004568 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 443149004569 active site 443149004570 ribulose/triose binding site [chemical binding]; other site 443149004571 phosphate binding site [ion binding]; other site 443149004572 substrate (anthranilate) binding pocket [chemical binding]; other site 443149004573 product (indole) binding pocket [chemical binding]; other site 443149004574 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 443149004575 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 443149004576 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443149004577 catalytic residue [active] 443149004578 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 443149004579 substrate binding site [chemical binding]; other site 443149004580 active site 443149004581 catalytic residues [active] 443149004582 heterodimer interface [polypeptide binding]; other site 443149004583 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108 443149004584 Prolipoprotein diacylglyceryltransferase [Cell envelope biogenesis, outer membrane]; Region: Lgt; COG0682 443149004585 TM2 domain; Region: TM2; pfam05154 443149004586 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 443149004587 pyruvate kinase; Provisional; Region: PRK06247 443149004588 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 443149004589 domain interfaces; other site 443149004590 active site 443149004591 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 443149004592 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 443149004593 active site 443149004594 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 443149004595 catalytic triad [active] 443149004596 dimer interface [polypeptide binding]; other site 443149004597 Uncharacterized conserved protein [Function unknown]; Region: COG2898 443149004598 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 443149004599 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 443149004600 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443149004601 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 443149004602 Walker A/P-loop; other site 443149004603 Walker A/P-loop; other site 443149004604 ATP binding site [chemical binding]; other site 443149004605 ATP binding site [chemical binding]; other site 443149004606 Q-loop/lid; other site 443149004607 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 443149004608 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443149004609 Walker A/P-loop; other site 443149004610 ATP binding site [chemical binding]; other site 443149004611 Q-loop/lid; other site 443149004612 ABC transporter signature motif; other site 443149004613 Walker B; other site 443149004614 D-loop; other site 443149004615 H-loop/switch region; other site 443149004616 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 443149004617 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 443149004618 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 443149004619 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 443149004620 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 443149004621 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 443149004622 cyclase homology domain; Region: CHD; cd07302 443149004623 nucleotidyl binding site; other site 443149004624 metal binding site [ion binding]; metal-binding site 443149004625 dimer interface [polypeptide binding]; other site 443149004626 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 443149004627 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443149004628 active site 443149004629 phosphorylation site [posttranslational modification] 443149004630 intermolecular recognition site; other site 443149004631 dimerization interface [polypeptide binding]; other site 443149004632 ANTAR domain; Region: ANTAR; pfam03861 443149004633 lipid-transfer protein; Provisional; Region: PRK06059 443149004634 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 443149004635 active site 443149004636 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 443149004637 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 443149004638 DUF35 OB-fold domain; Region: DUF35; pfam01796 443149004639 DNA polymerase I; Provisional; Region: PRK05755 443149004640 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 443149004641 active site 443149004642 metal binding site 1 [ion binding]; metal-binding site 443149004643 putative 5' ssDNA interaction site; other site 443149004644 metal binding site 3; metal-binding site 443149004645 metal binding site 2 [ion binding]; metal-binding site 443149004646 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 443149004647 putative DNA binding site [nucleotide binding]; other site 443149004648 putative metal binding site [ion binding]; other site 443149004649 3'-5' exonuclease; Region: 35EXOc; smart00474 443149004650 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 443149004651 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 443149004652 active site 443149004653 DNA binding site [nucleotide binding] 443149004654 catalytic site [active] 443149004655 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 443149004656 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 443149004657 RNA binding site [nucleotide binding]; other site 443149004658 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 443149004659 RNA binding site [nucleotide binding]; other site 443149004660 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 443149004661 RNA binding site [nucleotide binding]; other site 443149004662 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 443149004663 RNA binding site [nucleotide binding]; other site 443149004664 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 443149004665 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 443149004666 CoA-binding site [chemical binding]; other site 443149004667 ATP-binding [chemical binding]; other site 443149004668 Uncharacterized conserved protein [Function unknown]; Region: GrpB; COG2320 443149004669 Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306 443149004670 excinuclease ABC subunit B; Provisional; Region: PRK05298 443149004671 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443149004672 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443149004673 nucleotide binding region [chemical binding]; other site 443149004674 ATP-binding site [chemical binding]; other site 443149004675 Ultra-violet resistance protein B; Region: UvrB; pfam12344 443149004676 UvrB/uvrC motif; Region: UVR; pfam02151 443149004677 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443149004678 Major Facilitator Superfamily; Region: MFS_1; pfam07690 443149004679 putative substrate translocation pore; other site 443149004680 Predicted membrane protein [Function unknown]; Region: COG5305 443149004681 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 443149004682 Ligand Binding Site [chemical binding]; other site 443149004683 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 443149004684 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 443149004685 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 443149004686 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 443149004687 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 443149004688 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 443149004689 Predicted esterase [General function prediction only]; Region: COG0627 443149004690 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 443149004691 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 443149004692 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 443149004693 dimer interface [polypeptide binding]; other site 443149004694 putative anticodon binding site; other site 443149004695 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 443149004696 motif 1; other site 443149004697 dimer interface [polypeptide binding]; other site 443149004698 active site 443149004699 motif 2; other site 443149004700 motif 3; other site 443149004701 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 443149004702 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 443149004703 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 443149004704 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 443149004705 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 443149004706 23S rRNA binding site [nucleotide binding]; other site 443149004707 L21 binding site [polypeptide binding]; other site 443149004708 L13 binding site [polypeptide binding]; other site 443149004709 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 443149004710 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 443149004711 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 443149004712 PE family; Region: PE; pfam00934 443149004713 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 443149004714 cyclase homology domain; Region: CHD; cd07302 443149004715 nucleotidyl binding site; other site 443149004716 metal binding site [ion binding]; metal-binding site 443149004717 dimer interface [polypeptide binding]; other site 443149004718 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 443149004719 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 443149004720 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 443149004721 dimer interface [polypeptide binding]; other site 443149004722 motif 1; other site 443149004723 active site 443149004724 motif 2; other site 443149004725 motif 3; other site 443149004726 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 443149004727 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 443149004728 putative tRNA-binding site [nucleotide binding]; other site 443149004729 B3/4 domain; Region: B3_4; pfam03483 443149004730 tRNA synthetase B5 domain; Region: B5; smart00874 443149004731 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 443149004732 dimer interface [polypeptide binding]; other site 443149004733 motif 1; other site 443149004734 motif 3; other site 443149004735 motif 2; other site 443149004736 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 443149004737 PE family; Region: PE; pfam00934 443149004738 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 443149004739 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 443149004740 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 443149004741 heterotetramer interface [polypeptide binding]; other site 443149004742 active site pocket [active] 443149004743 cleavage site 443149004744 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 443149004745 feedback inhibition sensing region; other site 443149004746 homohexameric interface [polypeptide binding]; other site 443149004747 nucleotide binding site [chemical binding]; other site 443149004748 N-acetyl-L-glutamate binding site [chemical binding]; other site 443149004749 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 443149004750 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 443149004751 inhibitor-cofactor binding pocket; inhibition site 443149004752 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443149004753 catalytic residue [active] 443149004754 ornithine carbamoyltransferase; Provisional; Region: PRK00779 443149004755 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 443149004756 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 443149004757 arginine repressor; Provisional; Region: PRK03341 443149004758 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 443149004759 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 443149004760 argininosuccinate synthase; Provisional; Region: PRK13820 443149004761 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 443149004762 ANP binding site [chemical binding]; other site 443149004763 Substrate Binding Site II [chemical binding]; other site 443149004764 Substrate Binding Site I [chemical binding]; other site 443149004765 argininosuccinate lyase; Provisional; Region: PRK00855 443149004766 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 443149004767 active sites [active] 443149004768 tetramer interface [polypeptide binding]; other site 443149004769 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 443149004770 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 443149004771 malonyl-CoA binding site [chemical binding]; other site 443149004772 dimer interface [polypeptide binding]; other site 443149004773 active site 443149004774 product binding site; other site 443149004775 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 443149004776 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 443149004777 active site 443149004778 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 443149004779 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 443149004780 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443149004781 Enoylreductase; Region: PKS_ER; smart00829 443149004782 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 443149004783 NAD(P) binding site [chemical binding]; other site 443149004784 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 443149004785 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 443149004786 putative NADP binding site [chemical binding]; other site 443149004787 active site 443149004788 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 443149004789 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 443149004790 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 443149004791 active site 443149004792 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 443149004793 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 443149004794 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443149004795 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 443149004796 Enoylreductase; Region: PKS_ER; smart00829 443149004797 NAD(P) binding site [chemical binding]; other site 443149004798 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 443149004799 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 443149004800 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 443149004801 putative NADP binding site [chemical binding]; other site 443149004802 active site 443149004803 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 443149004804 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 443149004805 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 443149004806 active site 443149004807 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 443149004808 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 443149004809 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 443149004810 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 443149004811 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 443149004812 malonyl-CoA binding site [chemical binding]; other site 443149004813 dimer interface [polypeptide binding]; other site 443149004814 active site 443149004815 product binding site; other site 443149004816 Cytochrome P450; Region: p450; cl12078 443149004817 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443149004818 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 443149004819 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 443149004820 ABC transporter; Region: ABC_tran_2; pfam12848 443149004821 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 443149004822 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 443149004823 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443149004824 putative substrate translocation pore; other site 443149004825 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 443149004826 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 443149004827 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443149004828 dimerization interface [polypeptide binding]; other site 443149004829 putative DNA binding site [nucleotide binding]; other site 443149004830 putative Zn2+ binding site [ion binding]; other site 443149004831 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 443149004832 active site residue [active] 443149004833 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 443149004834 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 443149004835 ligand binding site [chemical binding]; other site 443149004836 flexible hinge region; other site 443149004837 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 443149004838 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 443149004839 putative catalytic residues [active] 443149004840 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 443149004841 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 443149004842 catalytic residues [active] 443149004843 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149004844 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443149004845 active site 443149004846 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 443149004847 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 443149004848 substrate binding pocket [chemical binding]; other site 443149004849 membrane-bound complex binding site; other site 443149004850 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 443149004851 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443149004852 FeS/SAM binding site; other site 443149004853 DivIVA protein; Region: DivIVA; pfam05103 443149004854 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 443149004855 acyl-CoA synthetase; Validated; Region: PRK07868 443149004856 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 443149004857 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443149004858 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443149004859 acyl-activating enzyme (AAE) consensus motif; other site 443149004860 AMP binding site [chemical binding]; other site 443149004861 active site 443149004862 CoA binding site [chemical binding]; other site 443149004863 Uncharacterized conserved protein [Function unknown]; Region: COG2835 443149004864 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149004865 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149004866 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 443149004867 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 443149004868 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 443149004869 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 443149004870 Walker A/P-loop; other site 443149004871 ATP binding site [chemical binding]; other site 443149004872 Q-loop/lid; other site 443149004873 ABC transporter signature motif; other site 443149004874 Walker B; other site 443149004875 D-loop; other site 443149004876 H-loop/switch region; other site 443149004877 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 443149004878 active site 443149004879 DNA binding site [nucleotide binding] 443149004880 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 443149004881 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 443149004882 active site 443149004883 HIGH motif; other site 443149004884 dimer interface [polypeptide binding]; other site 443149004885 KMSKS motif; other site 443149004886 S4 RNA-binding domain; Region: S4; smart00363 443149004887 RNA binding surface [nucleotide binding]; other site 443149004888 Protein of unknown function (DUF732); Region: DUF732; pfam05305 443149004889 Tetratrico peptide repeat; Region: TPR_5; pfam12688 443149004890 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 443149004891 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 443149004892 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 443149004893 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 443149004894 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 443149004895 RNA binding surface [nucleotide binding]; other site 443149004896 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149004897 S-adenosylmethionine binding site [chemical binding]; other site 443149004898 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 443149004899 ATP-NAD kinase; Region: NAD_kinase; pfam01513 443149004900 DNA repair protein RecN; Region: recN; TIGR00634 443149004901 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 443149004902 Walker A/P-loop; other site 443149004903 ATP binding site [chemical binding]; other site 443149004904 Q-loop/lid; other site 443149004905 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 443149004906 ABC transporter signature motif; other site 443149004907 Walker B; other site 443149004908 D-loop; other site 443149004909 H-loop/switch region; other site 443149004910 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 443149004911 Thiamine pyrophosphokinase; Region: TPK; cl08415 443149004912 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 443149004913 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 443149004914 CTP synthetase; Validated; Region: pyrG; PRK05380 443149004915 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 443149004916 Catalytic site [active] 443149004917 active site 443149004918 UTP binding site [chemical binding]; other site 443149004919 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 443149004920 active site 443149004921 putative oxyanion hole; other site 443149004922 catalytic triad [active] 443149004923 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 443149004924 dimer interface [polypeptide binding]; other site 443149004925 ADP-ribose binding site [chemical binding]; other site 443149004926 active site 443149004927 nudix motif; other site 443149004928 metal binding site [ion binding]; metal-binding site 443149004929 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 443149004930 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 443149004931 active site 443149004932 DNA binding site [nucleotide binding] 443149004933 Int/Topo IB signature motif; other site 443149004934 Domain of unknown function (DUF222); Region: DUF222; pfam02720 443149004935 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 443149004936 active site 443149004937 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 443149004938 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149004939 S-adenosylmethionine binding site [chemical binding]; other site 443149004940 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 443149004941 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149004942 PPE family; Region: PPE; pfam00823 443149004943 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 443149004944 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149004945 PPE family; Region: PPE; pfam00823 443149004946 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 443149004947 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 443149004948 Sulfate transporter family; Region: Sulfate_transp; pfam00916 443149004949 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 443149004950 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 443149004951 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 443149004952 P-loop; other site 443149004953 Magnesium ion binding site [ion binding]; other site 443149004954 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 443149004955 Magnesium ion binding site [ion binding]; other site 443149004956 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 443149004957 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 443149004958 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 443149004959 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 443149004960 RNA binding surface [nucleotide binding]; other site 443149004961 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 443149004962 active site 443149004963 cytidylate kinase; Provisional; Region: cmk; PRK00023 443149004964 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 443149004965 CMP-binding site; other site 443149004966 The sites determining sugar specificity; other site 443149004967 GTP-binding protein Der; Reviewed; Region: PRK03003 443149004968 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 443149004969 GTP/Mg2+ binding site [chemical binding]; other site 443149004970 Switch I region; other site 443149004971 G2 box; other site 443149004972 Switch II region; other site 443149004973 G3 box; other site 443149004974 G4 box; other site 443149004975 G5 box; other site 443149004976 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 443149004977 G1 box; other site 443149004978 GTP/Mg2+ binding site [chemical binding]; other site 443149004979 Switch I region; other site 443149004980 G2 box; other site 443149004981 G3 box; other site 443149004982 Switch II region; other site 443149004983 G4 box; other site 443149004984 G5 box; other site 443149004985 short chain dehydrogenase; Provisional; Region: PRK07060 443149004986 classical (c) SDRs; Region: SDR_c; cd05233 443149004987 NAD(P) binding site [chemical binding]; other site 443149004988 active site 443149004989 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 443149004990 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 443149004991 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 443149004992 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 443149004993 Cupin domain; Region: Cupin_2; pfam07883 443149004994 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 443149004995 Transcriptional regulator [Transcription]; Region: IclR; COG1414 443149004996 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 443149004997 putative switch regulator; other site 443149004998 non-specific DNA interactions [nucleotide binding]; other site 443149004999 DNA binding site [nucleotide binding] 443149005000 sequence specific DNA binding site [nucleotide binding]; other site 443149005001 putative cAMP binding site [chemical binding]; other site 443149005002 Bacterial transcriptional regulator; Region: IclR; pfam01614 443149005003 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 443149005004 putative active site [active] 443149005005 homotetrameric interface [polypeptide binding]; other site 443149005006 metal binding site [ion binding]; metal-binding site 443149005007 biotin carboxylase-like protein; Validated; Region: PRK06524 443149005008 ATP-grasp domain; Region: ATP-grasp_4; cl17255 443149005009 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 443149005010 Beta-lactamase; Region: Beta-lactamase; pfam00144 443149005011 Predicted transcriptional regulators [Transcription]; Region: COG1733 443149005012 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443149005013 dimerization interface [polypeptide binding]; other site 443149005014 putative DNA binding site [nucleotide binding]; other site 443149005015 putative Zn2+ binding site [ion binding]; other site 443149005016 Predicted transcriptional regulators [Transcription]; Region: COG1733 443149005017 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 443149005018 FAD binding domain; Region: FAD_binding_4; pfam01565 443149005019 Berberine and berberine like; Region: BBE; pfam08031 443149005020 TIGR03086 family protein; Region: TIGR03086 443149005021 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 443149005022 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 443149005023 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 443149005024 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 443149005025 Beta-lactamase; Region: Beta-lactamase; pfam00144 443149005026 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 443149005027 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 443149005028 NAD(P) binding site [chemical binding]; other site 443149005029 catalytic residues [active] 443149005030 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 443149005031 putative catalytic residue [active] 443149005032 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 443149005033 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 443149005034 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 443149005035 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 443149005036 gating phenylalanine in ion channel; other site 443149005037 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 443149005038 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 443149005039 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 443149005040 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 443149005041 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 443149005042 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443149005043 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 443149005044 putative substrate translocation pore; other site 443149005045 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 443149005046 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 443149005047 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 443149005048 Sulfate transporter family; Region: Sulfate_transp; pfam00916 443149005049 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 443149005050 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 443149005051 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3742 443149005052 putative active site [active] 443149005053 Protein tyrosine kinase; Region: Pkinase_Tyr; pfam07714 443149005054 Catalytic domain of Protein Kinases; Region: PKc; cd00180 443149005055 active site 443149005056 ATP binding site [chemical binding]; other site 443149005057 substrate binding site [chemical binding]; other site 443149005058 activation loop (A-loop); other site 443149005059 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 443149005060 Thioredoxin; Region: Thioredoxin_4; cl17273 443149005061 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 443149005062 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 443149005063 active site 443149005064 metal binding site [ion binding]; metal-binding site 443149005065 nudix motif; other site 443149005066 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 443149005067 Catalytic domain of Protein Kinases; Region: PKc; cd00180 443149005068 active site 443149005069 ATP binding site [chemical binding]; other site 443149005070 substrate binding site [chemical binding]; other site 443149005071 activation loop (A-loop); other site 443149005072 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 443149005073 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 443149005074 phosphopeptide binding site; other site 443149005075 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 443149005076 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 443149005077 phosphopeptide binding site; other site 443149005078 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 443149005079 The Eye Pigment Precursor Transporter (EPP) Family protein; Region: 3a01204; TIGR00955 443149005080 Walker A/P-loop; other site 443149005081 ATP binding site [chemical binding]; other site 443149005082 Q-loop/lid; other site 443149005083 ABC transporter signature motif; other site 443149005084 Walker B; other site 443149005085 D-loop; other site 443149005086 H-loop/switch region; other site 443149005087 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 443149005088 acyl-CoA synthetase; Provisional; Region: PRK13388 443149005089 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443149005090 acyl-activating enzyme (AAE) consensus motif; other site 443149005091 AMP binding site [chemical binding]; other site 443149005092 active site 443149005093 CoA binding site [chemical binding]; other site 443149005094 hypothetical protein; Provisional; Region: PRK06185 443149005095 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 443149005096 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 443149005097 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 443149005098 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149005099 PPE family; Region: PPE; pfam00823 443149005100 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149005101 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149005102 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 443149005103 putative transposase OrfB; Reviewed; Region: PHA02517 443149005104 HTH-like domain; Region: HTH_21; pfam13276 443149005105 Integrase core domain; Region: rve; pfam00665 443149005106 Integrase core domain; Region: rve_3; pfam13683 443149005107 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 443149005108 Transposase; Region: HTH_Tnp_1; cl17663 443149005109 Integrase core domain; Region: rve; pfam00665 443149005110 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 443149005111 putative homotetramer interface [polypeptide binding]; other site 443149005112 putative homodimer interface [polypeptide binding]; other site 443149005113 putative allosteric switch controlling residues; other site 443149005114 putative metal binding site [ion binding]; other site 443149005115 putative homodimer-homodimer interface [polypeptide binding]; other site 443149005116 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 443149005117 PE family; Region: PE; pfam00934 443149005118 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 443149005119 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 443149005120 dimer interface [polypeptide binding]; other site 443149005121 active site 443149005122 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 443149005123 substrate binding site [chemical binding]; other site 443149005124 catalytic residue [active] 443149005125 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 443149005126 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 443149005127 metal binding site [ion binding]; metal-binding site 443149005128 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 443149005129 FAD binding domain; Region: FAD_binding_4; pfam01565 443149005130 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 443149005131 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 443149005132 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 443149005133 Transcriptional regulator [Transcription]; Region: IclR; COG1414 443149005134 Bacterial transcriptional regulator; Region: IclR; pfam01614 443149005135 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 443149005136 FAD binding domain; Region: FAD_binding_4; pfam01565 443149005137 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149005138 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149005139 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443149005140 Cytochrome P450; Region: p450; cl12078 443149005141 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 443149005142 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 443149005143 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 443149005144 Protein of unknown function (DUF690); Region: DUF690; pfam05108 443149005145 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 443149005146 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 443149005147 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 443149005148 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 443149005149 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443149005150 Cytochrome P450; Region: p450; cl12078 443149005151 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 443149005152 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149005153 PPE family; Region: PPE; pfam00823 443149005154 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 443149005155 PE family; Region: PE; pfam00934 443149005156 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149005157 PPE family; Region: PPE; pfam00823 443149005158 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 443149005159 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149005160 PPE family; Region: PPE; pfam00823 443149005161 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 443149005162 PE family; Region: PE; pfam00934 443149005163 Proteins of 100 residues with WXG; Region: WXG100; cl02005 443149005164 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 443149005165 EspG family; Region: ESX-1_EspG; pfam14011 443149005166 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 443149005167 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 443149005168 catalytic residues [active] 443149005169 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 443149005170 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 443149005171 active site 443149005172 catalytic residues [active] 443149005173 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 443149005174 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 443149005175 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443149005176 Walker A motif; other site 443149005177 ATP binding site [chemical binding]; other site 443149005178 Walker B motif; other site 443149005179 arginine finger; other site 443149005180 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149005181 PPE family; Region: PPE; pfam00823 443149005182 PE-PPE domain; Region: PE-PPE; pfam08237 443149005183 putative transposase OrfB; Reviewed; Region: PHA02517 443149005184 HTH-like domain; Region: HTH_21; pfam13276 443149005185 Integrase core domain; Region: rve; pfam00665 443149005186 Integrase core domain; Region: rve_3; pfam13683 443149005187 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 443149005188 Transposase; Region: HTH_Tnp_1; cl17663 443149005189 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149005190 PPE family; Region: PPE; pfam00823 443149005191 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149005192 PPE family; Region: PPE; pfam00823 443149005193 PE family; Region: PE; pfam00934 443149005194 Protein of unknown function (DUF732); Region: DUF732; pfam05305 443149005195 PE family; Region: PE; pfam00934 443149005196 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149005197 PPE family; Region: PPE; pfam00823 443149005198 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149005199 PPE family; Region: PPE; pfam00823 443149005200 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149005201 PPE family; Region: PPE; pfam00823 443149005202 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 443149005203 Protein of unknown function (DUF732); Region: DUF732; pfam05305 443149005204 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 443149005205 MgtC family; Region: MgtC; pfam02308 443149005206 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 443149005207 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 443149005208 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 443149005209 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 443149005210 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 443149005211 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149005212 hypothetical protein; Validated; Region: PRK07121 443149005213 PE family; Region: PE; pfam00934 443149005214 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 443149005215 ABC transporter transmembrane region 2; Region: ABC_membrane_2; pfam06472 443149005216 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 443149005217 hypothetical protein; Provisional; Region: PRK05858 443149005218 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 443149005219 PYR/PP interface [polypeptide binding]; other site 443149005220 dimer interface [polypeptide binding]; other site 443149005221 TPP binding site [chemical binding]; other site 443149005222 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 443149005223 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 443149005224 TPP-binding site; other site 443149005225 dimer interface [polypeptide binding]; other site 443149005226 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 443149005227 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 443149005228 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 443149005229 nucleotide binding region [chemical binding]; other site 443149005230 ATP-binding site [chemical binding]; other site 443149005231 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 443149005232 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 443149005233 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 443149005234 Uncharacterized conserved protein (small basic protein) [Function unknown]; Region: Sbp; COG3856 443149005235 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 443149005236 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 443149005237 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 443149005238 lipoyl attachment site [posttranslational modification]; other site 443149005239 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 443149005240 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 443149005241 phosphopeptide binding site; other site 443149005242 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 443149005243 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 443149005244 DNA binding residues [nucleotide binding] 443149005245 Bifunctional nuclease; Region: DNase-RNase; pfam02577 443149005246 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 443149005247 DNA binding residues [nucleotide binding] 443149005248 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 443149005249 putative dimer interface [polypeptide binding]; other site 443149005250 glycine dehydrogenase; Provisional; Region: PRK05367 443149005251 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 443149005252 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443149005253 tetramer interface [polypeptide binding]; other site 443149005254 catalytic residue [active] 443149005255 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 443149005256 tetramer interface [polypeptide binding]; other site 443149005257 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443149005258 catalytic residue [active] 443149005259 haloalkane dehalogenase; Provisional; Region: PRK03204 443149005260 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443149005261 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 443149005262 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 443149005263 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 443149005264 metal ion-dependent adhesion site (MIDAS); other site 443149005265 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 443149005266 active site 443149005267 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 443149005268 putative active site [active] 443149005269 Domain of unknown function DUF21; Region: DUF21; pfam01595 443149005270 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 443149005271 FOG: CBS domain [General function prediction only]; Region: COG0517 443149005272 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 443149005273 Domain of unknown function DUF21; Region: DUF21; pfam01595 443149005274 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 443149005275 Transporter associated domain; Region: CorC_HlyC; smart01091 443149005276 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 443149005277 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 443149005278 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 443149005279 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 443149005280 active site 443149005281 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 443149005282 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 443149005283 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 443149005284 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 443149005285 Predicted transcriptional regulator [Transcription]; Region: COG3682 443149005286 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 443149005287 CoenzymeA binding site [chemical binding]; other site 443149005288 subunit interaction site [polypeptide binding]; other site 443149005289 PHB binding site; other site 443149005290 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 443149005291 alpha-gamma subunit interface [polypeptide binding]; other site 443149005292 beta-gamma subunit interface [polypeptide binding]; other site 443149005293 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 443149005294 gamma-beta subunit interface [polypeptide binding]; other site 443149005295 alpha-beta subunit interface [polypeptide binding]; other site 443149005296 urease subunit alpha; Reviewed; Region: ureC; PRK13206 443149005297 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 443149005298 subunit interactions [polypeptide binding]; other site 443149005299 active site 443149005300 flap region; other site 443149005301 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 443149005302 UreF; Region: UreF; pfam01730 443149005303 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 443149005304 UreD urease accessory protein; Region: UreD; cl00530 443149005305 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 443149005306 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443149005307 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 443149005308 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 443149005309 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 443149005310 classical (c) SDRs; Region: SDR_c; cd05233 443149005311 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 443149005312 NAD(P) binding site [chemical binding]; other site 443149005313 active site 443149005314 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 443149005315 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 443149005316 sulfate transport protein; Provisional; Region: cysT; CHL00187 443149005317 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443149005318 dimer interface [polypeptide binding]; other site 443149005319 conserved gate region; other site 443149005320 putative PBP binding loops; other site 443149005321 ABC-ATPase subunit interface; other site 443149005322 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 443149005323 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443149005324 Walker A/P-loop; other site 443149005325 ATP binding site [chemical binding]; other site 443149005326 Q-loop/lid; other site 443149005327 ABC transporter signature motif; other site 443149005328 Walker B; other site 443149005329 D-loop; other site 443149005330 H-loop/switch region; other site 443149005331 TOBE domain; Region: TOBE; pfam03459 443149005332 Fibronectin-attachment protein (FAP); Region: FAP; pfam07174 443149005333 Predicted membrane protein [Function unknown]; Region: COG2261 443149005334 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 443149005335 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 443149005336 putative NAD(P) binding site [chemical binding]; other site 443149005337 putative substrate binding site [chemical binding]; other site 443149005338 catalytic Zn binding site [ion binding]; other site 443149005339 structural Zn binding site [ion binding]; other site 443149005340 CAAX protease self-immunity; Region: Abi; pfam02517 443149005341 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 443149005342 MOSC domain; Region: MOSC; pfam03473 443149005343 short chain dehydrogenase; Provisional; Region: PRK07825 443149005344 classical (c) SDRs; Region: SDR_c; cd05233 443149005345 NAD(P) binding site [chemical binding]; other site 443149005346 active site 443149005347 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 443149005348 CoA-transferase family III; Region: CoA_transf_3; pfam02515 443149005349 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 443149005350 CoA-transferase family III; Region: CoA_transf_3; pfam02515 443149005351 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 443149005352 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 443149005353 active site 443149005354 hypothetical protein; Provisional; Region: PRK12320 443149005355 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443149005356 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 443149005357 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 443149005358 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443149005359 Domain of unknown function (DUF385); Region: DUF385; pfam04075 443149005360 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 443149005361 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 443149005362 active site 443149005363 substrate binding site [chemical binding]; other site 443149005364 FMN binding site [chemical binding]; other site 443149005365 putative catalytic residues [active] 443149005366 Uncharacterized conserved protein [Function unknown]; Region: COG5579 443149005367 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 443149005368 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 443149005369 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 443149005370 heme binding site [chemical binding]; other site 443149005371 ferroxidase pore; other site 443149005372 ferroxidase diiron center [ion binding]; other site 443149005373 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443149005374 Major Facilitator Superfamily; Region: MFS_1; pfam07690 443149005375 putative substrate translocation pore; other site 443149005376 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443149005377 putative substrate translocation pore; other site 443149005378 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cl00333 443149005379 23S rRNA interface [nucleotide binding]; other site 443149005380 L3 interface [polypeptide binding]; other site 443149005381 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 443149005382 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 443149005383 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 443149005384 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 443149005385 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443149005386 Cytochrome P450; Region: p450; cl12078 443149005387 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 443149005388 short chain dehydrogenase; Provisional; Region: PRK08267 443149005389 classical (c) SDR, subgroup 9; Region: SDR_c9; cd08931 443149005390 putative NAD(P) binding site [chemical binding]; other site 443149005391 active site 443149005392 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 443149005393 hydrophobic ligand binding site; other site 443149005394 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 443149005395 chorismate mutase; Provisional; Region: PRK09269 443149005396 chorismate mutase, putative; Region: CM_mono2; TIGR01806 443149005397 Putative esterase; Region: Esterase; pfam00756 443149005398 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 443149005399 Leucine carboxyl methyltransferase; Region: LCM; cl01306 443149005400 Uncharacterized conserved protein [Function unknown]; Region: COG2353 443149005401 Nitronate monooxygenase; Region: NMO; pfam03060 443149005402 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 443149005403 FMN binding site [chemical binding]; other site 443149005404 substrate binding site [chemical binding]; other site 443149005405 putative catalytic residue [active] 443149005406 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 2; Region: FDH_like_2; cd08284 443149005407 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 443149005408 catalytic Zn binding site [ion binding]; other site 443149005409 NAD(P) binding site [chemical binding]; other site 443149005410 structural Zn binding site [ion binding]; other site 443149005411 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 443149005412 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 443149005413 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 443149005414 putative active site [active] 443149005415 dimerization interface [polypeptide binding]; other site 443149005416 putative tRNAtyr binding site [nucleotide binding]; other site 443149005417 Domain of unknown function DUF77; Region: DUF77; pfam01910 443149005418 Macro domain, Unknown family 2. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_2; cd03330 443149005419 putative ADP-ribose binding site [chemical binding]; other site 443149005420 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443149005421 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 443149005422 cyclase homology domain; Region: CHD; cd07302 443149005423 nucleotidyl binding site; other site 443149005424 metal binding site [ion binding]; metal-binding site 443149005425 dimer interface [polypeptide binding]; other site 443149005426 competence damage-inducible protein A; Provisional; Region: PRK00549 443149005427 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 443149005428 putative MPT binding site; other site 443149005429 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 443149005430 putative sialic acid transporter; Region: 2A0112; TIGR00891 443149005431 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443149005432 putative substrate translocation pore; other site 443149005433 Predicted membrane protein [Function unknown]; Region: COG1950 443149005434 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 443149005435 anti sigma factor interaction site; other site 443149005436 regulatory phosphorylation site [posttranslational modification]; other site 443149005437 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 443149005438 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 443149005439 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 443149005440 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 443149005441 dimer interface [polypeptide binding]; other site 443149005442 active site 443149005443 heme binding site [chemical binding]; other site 443149005444 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 443149005445 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 443149005446 metal binding site 2 [ion binding]; metal-binding site 443149005447 putative DNA binding helix; other site 443149005448 metal binding site 1 [ion binding]; metal-binding site 443149005449 dimer interface [polypeptide binding]; other site 443149005450 structural Zn2+ binding site [ion binding]; other site 443149005451 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 443149005452 substrate binding site [chemical binding]; other site 443149005453 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 443149005454 substrate binding site [chemical binding]; other site 443149005455 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 443149005456 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR3; cd08275 443149005457 putative NAD(P) binding site [chemical binding]; other site 443149005458 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 443149005459 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 443149005460 tetramer interface [polypeptide binding]; other site 443149005461 active site 443149005462 Mg2+/Mn2+ binding site [ion binding]; other site 443149005463 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 443149005464 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149005465 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149005466 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149005467 putative transposase OrfB; Reviewed; Region: PHA02517 443149005468 HTH-like domain; Region: HTH_21; pfam13276 443149005469 Integrase core domain; Region: rve; pfam00665 443149005470 Integrase core domain; Region: rve_3; pfam13683 443149005471 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 443149005472 Transposase; Region: HTH_Tnp_1; cl17663 443149005473 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149005474 PPE family; Region: PPE; pfam00823 443149005475 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149005476 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149005477 PPE family; Region: PPE; pfam00823 443149005478 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149005479 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149005480 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 443149005481 putative hydrophobic ligand binding site [chemical binding]; other site 443149005482 protein interface [polypeptide binding]; other site 443149005483 gate; other site 443149005484 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 443149005485 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 443149005486 putative acyl-acceptor binding pocket; other site 443149005487 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 443149005488 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 443149005489 Beta-lactamase; Region: Beta-lactamase; pfam00144 443149005490 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 443149005491 Beta-lactamase; Region: Beta-lactamase; pfam00144 443149005492 putative fatty-acid--CoA ligase; Provisional; Region: PRK12476 443149005493 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 443149005494 acyl-activating enzyme (AAE) consensus motif; other site 443149005495 active site 443149005496 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 443149005497 Uncharacterized conserved protein [Function unknown]; Region: COG3361 443149005498 short chain dehydrogenase; Provisional; Region: PRK05867 443149005499 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443149005500 NAD(P) binding site [chemical binding]; other site 443149005501 active site 443149005502 TIGR03085 family protein; Region: TIGR03085 443149005503 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 443149005504 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 443149005505 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 443149005506 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 443149005507 conserved cys residue [active] 443149005508 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 443149005509 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 443149005510 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 443149005511 dimer interface [polypeptide binding]; other site 443149005512 catalytic triad [active] 443149005513 peroxidatic and resolving cysteines [active] 443149005514 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149005515 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 443149005516 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 443149005517 active site 443149005518 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149005519 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 443149005520 FAD binding site [chemical binding]; other site 443149005521 substrate binding site [chemical binding]; other site 443149005522 catalytic base [active] 443149005523 enoyl-CoA hydratase; Provisional; Region: PRK08290 443149005524 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443149005525 substrate binding site [chemical binding]; other site 443149005526 oxyanion hole (OAH) forming residues; other site 443149005527 trimer interface [polypeptide binding]; other site 443149005528 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 443149005529 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 443149005530 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 443149005531 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443149005532 catalytic loop [active] 443149005533 iron binding site [ion binding]; other site 443149005534 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 443149005535 FAD binding pocket [chemical binding]; other site 443149005536 FAD binding motif [chemical binding]; other site 443149005537 phosphate binding motif [ion binding]; other site 443149005538 beta-alpha-beta structure motif; other site 443149005539 NAD binding pocket [chemical binding]; other site 443149005540 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443149005541 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 443149005542 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 443149005543 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 443149005544 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 443149005545 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 443149005546 dimerization interface [polypeptide binding]; other site 443149005547 active site 443149005548 classical (c) SDR, subgroup 12; Region: SDR_c12; cd08944 443149005549 putative NAD(P) binding site [chemical binding]; other site 443149005550 active site 443149005551 homodimer interface [polypeptide binding]; other site 443149005552 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 443149005553 SEC-C motif; Region: SEC-C; pfam02810 443149005554 Domain of unknown function (DUF222); Region: DUF222; pfam02720 443149005555 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 443149005556 active site 443149005557 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 443149005558 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487 443149005559 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 443149005560 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443149005561 non-specific DNA binding site [nucleotide binding]; other site 443149005562 salt bridge; other site 443149005563 sequence-specific DNA binding site [nucleotide binding]; other site 443149005564 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 443149005565 Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693 443149005566 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 443149005567 putative active site [active] 443149005568 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 443149005569 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149005570 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149005571 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149005572 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 443149005573 Permease; Region: Permease; pfam02405 443149005574 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 443149005575 Permease; Region: Permease; pfam02405 443149005576 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443149005577 mce related protein; Region: MCE; pfam02470 443149005578 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 443149005579 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443149005580 mce related protein; Region: MCE; pfam02470 443149005581 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443149005582 mce related protein; Region: MCE; pfam02470 443149005583 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443149005584 mce related protein; Region: MCE; pfam02470 443149005585 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443149005586 mce related protein; Region: MCE; pfam02470 443149005587 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443149005588 mce related protein; Region: MCE; pfam02470 443149005589 Protein of unknown function (DUF732); Region: DUF732; pfam05305 443149005590 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 443149005591 YacP-like NYN domain; Region: NYN_YacP; cl01491 443149005592 PE family; Region: PE; pfam00934 443149005593 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 443149005594 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 443149005595 Peptidase family M48; Region: Peptidase_M48; pfam01435 443149005596 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149005597 S-adenosylmethionine binding site [chemical binding]; other site 443149005598 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 443149005599 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 443149005600 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 443149005601 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 443149005602 dimer interface [polypeptide binding]; other site 443149005603 putative radical transfer pathway; other site 443149005604 diiron center [ion binding]; other site 443149005605 tyrosyl radical; other site 443149005606 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 443149005607 putative active site [active] 443149005608 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 443149005609 PE family; Region: PE; pfam00934 443149005610 Cutinase; Region: Cutinase; pfam01083 443149005611 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 443149005612 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 443149005613 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 443149005614 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 443149005615 dimerization interface [polypeptide binding]; other site 443149005616 Lysine efflux permease [General function prediction only]; Region: COG1279 443149005617 Cellulose binding domain; Region: CBM_2; pfam00553 443149005618 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149005619 S-adenosylmethionine binding site [chemical binding]; other site 443149005620 Uncharacterized conserved protein [Function unknown]; Region: COG5654 443149005621 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 443149005622 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 443149005623 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443149005624 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 443149005625 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 443149005626 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 443149005627 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 443149005628 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 443149005629 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443149005630 dimerization interface [polypeptide binding]; other site 443149005631 putative DNA binding site [nucleotide binding]; other site 443149005632 putative Zn2+ binding site [ion binding]; other site 443149005633 Hemerythrin-like domain; Region: Hr-like; cd12108 443149005634 Fe binding site [ion binding]; other site 443149005635 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 443149005636 Ligand Binding Site [chemical binding]; other site 443149005637 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 443149005638 Ligand Binding Site [chemical binding]; other site 443149005639 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 443149005640 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 443149005641 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 443149005642 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 443149005643 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 443149005644 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 443149005645 Soluble P-type ATPase [General function prediction only]; Region: COG4087 443149005646 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 443149005647 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 443149005648 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 443149005649 tetramer interface [polypeptide binding]; other site 443149005650 active site 443149005651 Mg2+/Mn2+ binding site [ion binding]; other site 443149005652 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 443149005653 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 443149005654 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 443149005655 3beta17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 3beta-17beta-HSD_like_SDR_c; cd05341 443149005656 homotetramer interface [polypeptide binding]; other site 443149005657 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 443149005658 NAD binding site [chemical binding]; other site 443149005659 homodimer interface [polypeptide binding]; other site 443149005660 active site 443149005661 Methyltransferase domain; Region: Methyltransf_23; pfam13489 443149005662 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149005663 S-adenosylmethionine binding site [chemical binding]; other site 443149005664 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 443149005665 Predicted kinase [General function prediction only]; Region: COG0645 443149005666 AAA domain; Region: AAA_17; pfam13207 443149005667 Universal stress protein family; Region: Usp; pfam00582 443149005668 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 443149005669 Ligand Binding Site [chemical binding]; other site 443149005670 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 443149005671 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 443149005672 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 443149005673 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 443149005674 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 443149005675 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 443149005676 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 443149005677 Ferredoxin [Energy production and conversion]; Region: COG1146 443149005678 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 443149005679 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 443149005680 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443149005681 Walker A motif; other site 443149005682 ATP binding site [chemical binding]; other site 443149005683 Walker B motif; other site 443149005684 arginine finger; other site 443149005685 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 443149005686 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 443149005687 putative active site [active] 443149005688 Transcriptional regulators [Transcription]; Region: MarR; COG1846 443149005689 MarR family; Region: MarR_2; pfam12802 443149005690 Phage envelope protein [General function prediction only]; Region: COG5562 443149005691 Predicted helicase [General function prediction only]; Region: COG4889 443149005692 Transposase; Region: DEDD_Tnp_IS110; pfam01548 443149005693 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 443149005694 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 443149005695 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 443149005696 Domain of unknown function (DUF222); Region: DUF222; pfam02720 443149005697 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 443149005698 active site 443149005699 putative transposase OrfB; Reviewed; Region: PHA02517 443149005700 HTH-like domain; Region: HTH_21; pfam13276 443149005701 Integrase core domain; Region: rve; pfam00665 443149005702 Integrase core domain; Region: rve_3; pfam13683 443149005703 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 443149005704 Transposase; Region: HTH_Tnp_1; cl17663 443149005705 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 443149005706 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443149005707 non-specific DNA binding site [nucleotide binding]; other site 443149005708 salt bridge; other site 443149005709 sequence-specific DNA binding site [nucleotide binding]; other site 443149005710 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 443149005711 Uncharacterized conserved protein [Function unknown]; Region: COG2442 443149005712 Predicted helicase [General function prediction only]; Region: COG4889 443149005713 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443149005714 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 443149005715 non-specific DNA binding site [nucleotide binding]; other site 443149005716 salt bridge; other site 443149005717 sequence-specific DNA binding site [nucleotide binding]; other site 443149005718 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4683 443149005719 Predicted helicase [General function prediction only]; Region: COG4889 443149005720 Restriction endonuclease; Region: Mrr_cat_2; pfam13156 443149005721 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 443149005722 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443149005723 ATP binding site [chemical binding]; other site 443149005724 putative Mg++ binding site [ion binding]; other site 443149005725 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 443149005726 ATP-binding site [chemical binding]; other site 443149005727 Methyltransferase domain; Region: Methyltransf_26; pfam13659 443149005728 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 443149005729 Transposase; Region: HTH_Tnp_1; cl17663 443149005730 putative transposase OrfB; Reviewed; Region: PHA02517 443149005731 HTH-like domain; Region: HTH_21; pfam13276 443149005732 Integrase core domain; Region: rve; pfam00665 443149005733 Integrase core domain; Region: rve_3; pfam13683 443149005734 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 443149005735 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 443149005736 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 443149005737 Ligand Binding Site [chemical binding]; other site 443149005738 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 443149005739 Ligand Binding Site [chemical binding]; other site 443149005740 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 443149005741 Histidine kinase; Region: HisKA_3; pfam07730 443149005742 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 443149005743 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 443149005744 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 443149005745 Ligand Binding Site [chemical binding]; other site 443149005746 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 443149005747 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 443149005748 putative substrate binding site [chemical binding]; other site 443149005749 putative ATP binding site [chemical binding]; other site 443149005750 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 443149005751 active site 443149005752 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 443149005753 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 443149005754 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 443149005755 putative dimer interface [polypeptide binding]; other site 443149005756 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 443149005757 dimer interface [polypeptide binding]; other site 443149005758 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 443149005759 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443149005760 putative DNA binding site [nucleotide binding]; other site 443149005761 dimerization interface [polypeptide binding]; other site 443149005762 putative Zn2+ binding site [ion binding]; other site 443149005763 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 443149005764 putative hydrophobic ligand binding site [chemical binding]; other site 443149005765 CLM binding site; other site 443149005766 L1 loop; other site 443149005767 DNA binding site [nucleotide binding] 443149005768 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 443149005769 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 443149005770 MDMPI C-terminal domain; Region: MDMPI_C; pfam07398 443149005771 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 443149005772 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 443149005773 nucleophile elbow; other site 443149005774 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 443149005775 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 443149005776 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 443149005777 Walker A/P-loop; other site 443149005778 ATP binding site [chemical binding]; other site 443149005779 Q-loop/lid; other site 443149005780 ABC transporter signature motif; other site 443149005781 Walker B; other site 443149005782 D-loop; other site 443149005783 H-loop/switch region; other site 443149005784 TOBE domain; Region: TOBE_2; pfam08402 443149005785 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 443149005786 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443149005787 dimer interface [polypeptide binding]; other site 443149005788 conserved gate region; other site 443149005789 putative PBP binding loops; other site 443149005790 ABC-ATPase subunit interface; other site 443149005791 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 443149005792 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443149005793 dimer interface [polypeptide binding]; other site 443149005794 conserved gate region; other site 443149005795 putative PBP binding loops; other site 443149005796 ABC-ATPase subunit interface; other site 443149005797 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 443149005798 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 443149005799 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 443149005800 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 443149005801 Isochorismatase family; Region: Isochorismatase; pfam00857 443149005802 catalytic triad [active] 443149005803 metal binding site [ion binding]; metal-binding site 443149005804 conserved cis-peptide bond; other site 443149005805 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 443149005806 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 443149005807 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 443149005808 substrate binding pocket [chemical binding]; other site 443149005809 catalytic triad [active] 443149005810 hypothetical protein; Provisional; Region: PRK05865 443149005811 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443149005812 NAD(P) binding site [chemical binding]; other site 443149005813 active site 443149005814 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 443149005815 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 443149005816 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 443149005817 active site 443149005818 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 443149005819 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 443149005820 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443149005821 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 443149005822 Enoylreductase; Region: PKS_ER; smart00829 443149005823 NAD(P) binding site [chemical binding]; other site 443149005824 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 443149005825 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 443149005826 putative NADP binding site [chemical binding]; other site 443149005827 active site 443149005828 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 443149005829 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 443149005830 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 443149005831 active site 443149005832 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 443149005833 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 443149005834 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443149005835 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 443149005836 Enoylreductase; Region: PKS_ER; smart00829 443149005837 NAD(P) binding site [chemical binding]; other site 443149005838 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 443149005839 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 443149005840 putative NADP binding site [chemical binding]; other site 443149005841 active site 443149005842 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 443149005843 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 443149005844 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 443149005845 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 443149005846 putative active site [active] 443149005847 catalytic triad [active] 443149005848 putative dimer interface [polypeptide binding]; other site 443149005849 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 443149005850 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 443149005851 Ligand binding site; other site 443149005852 Putative Catalytic site; other site 443149005853 DXD motif; other site 443149005854 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 443149005855 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 443149005856 active site 443149005857 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 443149005858 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 443149005859 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 443149005860 30S ribosomal protein S18; Provisional; Region: PRK13401 443149005861 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 443149005862 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 443149005863 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 443149005864 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 443149005865 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 443149005866 intersubunit interface [polypeptide binding]; other site 443149005867 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 443149005868 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 443149005869 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 443149005870 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 443149005871 precorrin-3B synthase; Region: CobG; TIGR02435 443149005872 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 443149005873 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 443149005874 Precorrin-8X methylmutase; Region: CbiC; pfam02570 443149005875 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 443149005876 active site 443149005877 SAM binding site [chemical binding]; other site 443149005878 homodimer interface [polypeptide binding]; other site 443149005879 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 443149005880 active site 443149005881 SAM binding site [chemical binding]; other site 443149005882 homodimer interface [polypeptide binding]; other site 443149005883 Methyltransferase domain; Region: Methyltransf_31; pfam13847 443149005884 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149005885 S-adenosylmethionine binding site [chemical binding]; other site 443149005886 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 443149005887 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 443149005888 RNA polymerase sigma factor SigC; Reviewed; Region: PRK09649 443149005889 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443149005890 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443149005891 DNA binding residues [nucleotide binding] 443149005892 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 443149005893 precorrin-6x reductase; Region: precor6x_red; TIGR00715 443149005894 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 443149005895 active site 443149005896 SAM binding site [chemical binding]; other site 443149005897 homodimer interface [polypeptide binding]; other site 443149005898 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 443149005899 active site 443149005900 putative homodimer interface [polypeptide binding]; other site 443149005901 SAM binding site [chemical binding]; other site 443149005902 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 443149005903 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 443149005904 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443149005905 NAD(P) binding site [chemical binding]; other site 443149005906 active site 443149005907 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 443149005908 Catalytic domain of uncharacterized Mycobacterium tuberculosis Rv2075c-like proteins; Region: PI-PLCc_Rv2075c_like; cd08590 443149005909 putative active site [active] 443149005910 catalytic site [active] 443149005911 putative metal binding site [ion binding]; other site 443149005912 C-type lectin (CTL)/C-type lectin-like (CTLD) domain; Region: CLECT; cl02432 443149005913 Protein of unknown function (DUF2563); Region: DUF2563; pfam10817 443149005914 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 443149005915 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 443149005916 Catalytic domain of Protein Kinases; Region: PKc; cd00180 443149005917 active site 443149005918 ATP binding site [chemical binding]; other site 443149005919 substrate binding site [chemical binding]; other site 443149005920 activation loop (A-loop); other site 443149005921 PknH-like extracellular domain; Region: PknH_C; pfam14032 443149005922 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 443149005923 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 443149005924 active site 443149005925 5'-3' exonuclease, N-terminal resolvase-like domain; Region: 5_3_exonuc_N; pfam02739 443149005926 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 443149005927 active site 443149005928 metal binding site 1 [ion binding]; metal-binding site 443149005929 putative 5' ssDNA interaction site; other site 443149005930 metal binding site 3; metal-binding site 443149005931 metal binding site 2 [ion binding]; metal-binding site 443149005932 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 443149005933 putative DNA binding site [nucleotide binding]; other site 443149005934 putative metal binding site [ion binding]; other site 443149005935 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 443149005936 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 443149005937 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443149005938 ATP binding site [chemical binding]; other site 443149005939 putative Mg++ binding site [ion binding]; other site 443149005940 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443149005941 nucleotide binding region [chemical binding]; other site 443149005942 ATP-binding site [chemical binding]; other site 443149005943 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 443149005944 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 443149005945 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 443149005946 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 443149005947 Predicted transcriptional regulator [Transcription]; Region: COG2378 443149005948 WYL domain; Region: WYL; pfam13280 443149005949 Predicted transcriptional regulator [Transcription]; Region: COG2378 443149005950 WYL domain; Region: WYL; pfam13280 443149005951 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 443149005952 PE family; Region: PE; pfam00934 443149005953 Domain of unknown function (DUF222); Region: DUF222; pfam02720 443149005954 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 443149005955 active site 443149005956 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 443149005957 SNF2 Helicase protein; Region: DUF3670; pfam12419 443149005958 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443149005959 ATP binding site [chemical binding]; other site 443149005960 putative Mg++ binding site [ion binding]; other site 443149005961 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443149005962 nucleotide binding region [chemical binding]; other site 443149005963 ATP-binding site [chemical binding]; other site 443149005964 Uncharacterized conserved protein [Function unknown]; Region: COG4279 443149005965 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 443149005966 putative active site [active] 443149005967 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 443149005968 Transposase; Region: HTH_Tnp_1; cl17663 443149005969 putative transposase OrfB; Reviewed; Region: PHA02517 443149005970 HTH-like domain; Region: HTH_21; pfam13276 443149005971 Integrase core domain; Region: rve; pfam00665 443149005972 Integrase core domain; Region: rve_3; pfam13683 443149005973 putative transposase OrfB; Reviewed; Region: PHA02517 443149005974 HTH-like domain; Region: HTH_21; pfam13276 443149005975 Integrase core domain; Region: rve; pfam00665 443149005976 Integrase core domain; Region: rve_3; pfam13683 443149005977 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 443149005978 Transposase; Region: HTH_Tnp_1; cl17663 443149005979 PE family; Region: PE; pfam00934 443149005980 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149005981 PPE family; Region: PPE; pfam00823 443149005982 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 443149005983 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 443149005984 active site 443149005985 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 443149005986 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 443149005987 active site 443149005988 Pup-like protein; Region: Pup; pfam05639 443149005989 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 443149005990 proteasome ATPase; Region: pup_AAA; TIGR03689 443149005991 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443149005992 Walker A motif; other site 443149005993 ATP binding site [chemical binding]; other site 443149005994 Walker B motif; other site 443149005995 arginine finger; other site 443149005996 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 443149005997 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550 443149005998 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 443149005999 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149006000 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 443149006001 Predicted membrane protein [Function unknown]; Region: COG3918 443149006002 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 443149006003 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 443149006004 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 443149006005 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 443149006006 homodimer interface [polypeptide binding]; other site 443149006007 putative metal binding site [ion binding]; other site 443149006008 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149006009 PPE family; Region: PPE; pfam00823 443149006010 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 443149006011 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 443149006012 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 443149006013 substrate binding pocket [chemical binding]; other site 443149006014 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 443149006015 B12 binding site [chemical binding]; other site 443149006016 cobalt ligand [ion binding]; other site 443149006017 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 443149006018 PAC2 family; Region: PAC2; pfam09754 443149006019 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 443149006020 short chain dehydrogenase; Provisional; Region: PRK05872 443149006021 classical (c) SDRs; Region: SDR_c; cd05233 443149006022 NAD(P) binding site [chemical binding]; other site 443149006023 active site 443149006024 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 443149006025 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 443149006026 active site 443149006027 HIGH motif; other site 443149006028 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 443149006029 active site 443149006030 KMSKS motif; other site 443149006031 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 443149006032 putative tRNA binding surface [nucleotide binding]; other site 443149006033 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 443149006034 active site 443149006035 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 443149006036 conserved hypothetical protein; Region: TIGR03843 443149006037 conserved hypothetical protein; Region: TIGR03847 443149006038 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 443149006039 catalytic core [active] 443149006040 undecaprenyl-diphosphatase UppP; Region: undec_PP_bacA; TIGR00753 443149006041 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 443149006042 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 443149006043 quinone interaction residues [chemical binding]; other site 443149006044 active site 443149006045 catalytic residues [active] 443149006046 FMN binding site [chemical binding]; other site 443149006047 substrate binding site [chemical binding]; other site 443149006048 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 443149006049 substrate binding site [chemical binding]; other site 443149006050 hypothetical protein; Provisional; Region: PRK07906 443149006051 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 443149006052 putative metal binding site [ion binding]; other site 443149006053 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 443149006054 Putative addiction module component; Region: Unstab_antitox; cl09921 443149006055 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 443149006056 active site 443149006057 DivIVA domain; Region: DivI1A_domain; TIGR03544 443149006058 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 443149006059 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 443149006060 Predicted integral membrane protein [Function unknown]; Region: COG0762 443149006061 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 443149006062 Predicted enzyme with a TIM-barrel fold [General function prediction only]; Region: COG0325 443149006063 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 443149006064 catalytic residue [active] 443149006065 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 443149006066 uncharacterized protein, YfiH family; Region: TIGR00726 443149006067 cell division protein FtsZ; Validated; Region: PRK09330 443149006068 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 443149006069 nucleotide binding site [chemical binding]; other site 443149006070 SulA interaction site; other site 443149006071 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 443149006072 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 443149006073 Cell division protein FtsQ; Region: FtsQ; pfam03799 443149006074 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 443149006075 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 443149006076 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 443149006077 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 443149006078 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 443149006079 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 443149006080 active site 443149006081 homodimer interface [polypeptide binding]; other site 443149006082 cell division protein FtsW; Region: ftsW; TIGR02614 443149006083 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369 443149006084 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 443149006085 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 443149006086 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 443149006087 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 443149006088 Mg++ binding site [ion binding]; other site 443149006089 putative catalytic motif [active] 443149006090 putative substrate binding site [chemical binding]; other site 443149006091 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 443149006092 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 443149006093 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 443149006094 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 443149006095 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 443149006096 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 443149006097 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 443149006098 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149006099 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149006100 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 443149006101 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 443149006102 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 443149006103 PE family; Region: PE; pfam00934 443149006104 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 443149006105 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 443149006106 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 443149006107 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 443149006108 MraW methylase family; Region: Methyltransf_5; pfam01795 443149006109 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 443149006110 MraZ protein; Region: MraZ; pfam02381 443149006111 MraZ protein; Region: MraZ; pfam02381 443149006112 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 443149006113 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 443149006114 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 443149006115 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 443149006116 substrate binding pocket [chemical binding]; other site 443149006117 chain length determination region; other site 443149006118 substrate-Mg2+ binding site; other site 443149006119 catalytic residues [active] 443149006120 aspartate-rich region 1; other site 443149006121 active site lid residues [active] 443149006122 aspartate-rich region 2; other site 443149006123 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 443149006124 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 443149006125 Catalytic domain of Protein Kinases; Region: PKc; cd00180 443149006126 active site 443149006127 ATP binding site [chemical binding]; other site 443149006128 substrate binding site [chemical binding]; other site 443149006129 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 443149006130 substrate binding site [chemical binding]; other site 443149006131 activation loop (A-loop); other site 443149006132 activation loop (A-loop); other site 443149006133 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 443149006134 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 443149006135 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG3200 443149006136 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 443149006137 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 443149006138 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 443149006139 putative acyl-acceptor binding pocket; other site 443149006140 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 443149006141 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 443149006142 DTAP/Switch II; other site 443149006143 Switch I; other site 443149006144 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 443149006145 putative hydrophobic ligand binding site [chemical binding]; other site 443149006146 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 443149006147 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 443149006148 acyl-activating enzyme (AAE) consensus motif; other site 443149006149 putative AMP binding site [chemical binding]; other site 443149006150 putative active site [active] 443149006151 putative CoA binding site [chemical binding]; other site 443149006152 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 443149006153 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443149006154 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 443149006155 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 443149006156 NlpC/P60 family; Region: NLPC_P60; pfam00877 443149006157 hypothetical protein; Validated; Region: PRK07883 443149006158 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 443149006159 active site 443149006160 catalytic site [active] 443149006161 substrate binding site [chemical binding]; other site 443149006162 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 443149006163 GIY-YIG motif/motif A; other site 443149006164 active site 443149006165 catalytic site [active] 443149006166 putative DNA binding site [nucleotide binding]; other site 443149006167 metal binding site [ion binding]; metal-binding site 443149006168 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 443149006169 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 443149006170 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 443149006171 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 443149006172 Subunit I/III interface [polypeptide binding]; other site 443149006173 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 443149006174 Cytochrome c; Region: Cytochrom_C; pfam00034 443149006175 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 443149006176 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 443149006177 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 443149006178 iron-sulfur cluster [ion binding]; other site 443149006179 [2Fe-2S] cluster binding site [ion binding]; other site 443149006180 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 443149006181 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 443149006182 heme bH binding site [chemical binding]; other site 443149006183 intrachain domain interface; other site 443149006184 heme bL binding site [chemical binding]; other site 443149006185 interchain domain interface [polypeptide binding]; other site 443149006186 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 443149006187 Qo binding site; other site 443149006188 Protein of unknown function (DUF2561); Region: DUF2561; pfam10812 443149006189 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 443149006190 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 443149006191 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 443149006192 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 443149006193 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 443149006194 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 443149006195 dimer interface [polypeptide binding]; other site 443149006196 active site 443149006197 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 443149006198 Ligand Binding Site [chemical binding]; other site 443149006199 Molecular Tunnel; other site 443149006200 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 443149006201 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 443149006202 substrate binding site [chemical binding]; other site 443149006203 ATP binding site [chemical binding]; other site 443149006204 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 443149006205 Glycerate kinase family; Region: Gly_kinase; pfam02595 443149006206 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 443149006207 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 443149006208 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 443149006209 putative dimer interface [polypeptide binding]; other site 443149006210 active site pocket [active] 443149006211 putative cataytic base [active] 443149006212 Cobalamin-5-phosphate synthase; Region: CobS; pfam02654 443149006213 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 443149006214 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 443149006215 homodimer interface [polypeptide binding]; other site 443149006216 substrate-cofactor binding pocket; other site 443149006217 catalytic residue [active] 443149006218 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 443149006219 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 443149006220 cyclase homology domain; Region: CHD; cd07302 443149006221 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 443149006222 nucleotidyl binding site; other site 443149006223 metal binding site [ion binding]; metal-binding site 443149006224 dimer interface [polypeptide binding]; other site 443149006225 multifunctional aminopeptidase A; Provisional; Region: PRK00913 443149006226 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 443149006227 interface (dimer of trimers) [polypeptide binding]; other site 443149006228 Substrate-binding/catalytic site; other site 443149006229 Zn-binding sites [ion binding]; other site 443149006230 short chain dehydrogenase; Validated; Region: PRK05855 443149006231 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 443149006232 classical (c) SDRs; Region: SDR_c; cd05233 443149006233 NAD(P) binding site [chemical binding]; other site 443149006234 active site 443149006235 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 443149006236 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 443149006237 E3 interaction surface; other site 443149006238 lipoyl attachment site [posttranslational modification]; other site 443149006239 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 443149006240 E3 interaction surface; other site 443149006241 lipoyl attachment site [posttranslational modification]; other site 443149006242 e3 binding domain; Region: E3_binding; pfam02817 443149006243 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 443149006244 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 443149006245 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 443149006246 putative NAD(P) binding site [chemical binding]; other site 443149006247 putative active site [active] 443149006248 lipoate-protein ligase B; Provisional; Region: PRK14345 443149006249 lipoyl synthase; Provisional; Region: PRK05481 443149006250 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443149006251 FeS/SAM binding site; other site 443149006252 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 443149006253 RDD family; Region: RDD; pfam06271 443149006254 glutamine synthetase, type I; Region: GlnA; TIGR00653 443149006255 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 443149006256 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 443149006257 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 443149006258 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 443149006259 metal binding triad; other site 443149006260 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 443149006261 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 443149006262 metal binding triad; other site 443149006263 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 443149006264 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 443149006265 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 443149006266 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 443149006267 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 443149006268 TAP-like protein; Region: Abhydrolase_4; pfam08386 443149006269 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 443149006270 TAP-like protein; Region: Abhydrolase_4; pfam08386 443149006271 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443149006272 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 443149006273 oligomerization interface [polypeptide binding]; other site 443149006274 active site 443149006275 metal binding site [ion binding]; metal-binding site 443149006276 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 443149006277 putative active site; other site 443149006278 putative metal binding residues [ion binding]; other site 443149006279 signature motif; other site 443149006280 putative triphosphate binding site [ion binding]; other site 443149006281 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 443149006282 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3826 443149006283 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 443149006284 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 443149006285 RNA/DNA hybrid binding site [nucleotide binding]; other site 443149006286 active site 443149006287 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 443149006288 catalytic core [active] 443149006289 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 443149006290 Putative zinc ribbon domain; Region: DUF164; pfam02591 443149006291 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 443149006292 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 443149006293 Uncharacterized conserved protein [Function unknown]; Region: COG0327 443149006294 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 443149006295 hypothetical protein; Provisional; Region: PRK07908 443149006296 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443149006297 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443149006298 homodimer interface [polypeptide binding]; other site 443149006299 catalytic residue [active] 443149006300 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 443149006301 phosphoglycolate phosphatase; Provisional; Region: PRK13222 443149006302 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443149006303 active site 443149006304 motif I; other site 443149006305 motif II; other site 443149006306 Low molecular weight phosphatase family; Region: LMWPc; cd00115 443149006307 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 443149006308 active site 443149006309 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 443149006310 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 443149006311 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 443149006312 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 443149006313 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 443149006314 dimer interface [polypeptide binding]; other site 443149006315 catalytic triad [active] 443149006316 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 443149006317 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 443149006318 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 443149006319 dimer interface [polypeptide binding]; other site 443149006320 TPP-binding site [chemical binding]; other site 443149006321 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 443149006322 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 443149006323 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 443149006324 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 443149006325 acyl carrier protein; Provisional; Region: acpP; PRK00982 443149006326 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 443149006327 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 443149006328 dimer interface [polypeptide binding]; other site 443149006329 active site 443149006330 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 443149006331 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 443149006332 dimer interface [polypeptide binding]; other site 443149006333 active site 443149006334 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 443149006335 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 443149006336 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 443149006337 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 443149006338 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 443149006339 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149006340 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149006341 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 443149006342 FAD binding domain; Region: FAD_binding_4; pfam01565 443149006343 diacylglycerol kinase; Reviewed; Region: PRK11914 443149006344 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 443149006345 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 443149006346 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 443149006347 Beta-lactamase; Region: Beta-lactamase; pfam00144 443149006348 Methyltransferase domain; Region: Methyltransf_31; pfam13847 443149006349 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149006350 S-adenosylmethionine binding site [chemical binding]; other site 443149006351 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 443149006352 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 443149006353 NAD binding site [chemical binding]; other site 443149006354 catalytic Zn binding site [ion binding]; other site 443149006355 substrate binding site [chemical binding]; other site 443149006356 structural Zn binding site [ion binding]; other site 443149006357 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 443149006358 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 443149006359 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 443149006360 putative active site [active] 443149006361 catalytic triad [active] 443149006362 putative dimer interface [polypeptide binding]; other site 443149006363 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443149006364 active site 443149006365 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 443149006366 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 443149006367 nucleotide binding site [chemical binding]; other site 443149006368 Major Facilitator Superfamily; Region: MFS_1; pfam07690 443149006369 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443149006370 Cytochrome P450; Region: p450; cl12078 443149006371 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 443149006372 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443149006373 Cytochrome P450; Region: p450; cl12078 443149006374 Septum formation; Region: Septum_form; pfam13845 443149006375 Protein of unknown function (DUF2695); Region: DUF2695; pfam10905 443149006376 Predicted membrane protein [Function unknown]; Region: COG2149 443149006377 Domain of unknown function (DUF202); Region: DUF202; pfam02656 443149006378 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443149006379 Cytochrome P450; Region: p450; cl12078 443149006380 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial protein Rv2277c and similar proteins; Region: GDPD_Rv2277c_like; cd08580 443149006381 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 443149006382 putative active site [active] 443149006383 catalytic site [active] 443149006384 putative metal binding site [ion binding]; other site 443149006385 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 443149006386 FAD binding domain; Region: FAD_binding_4; pfam01565 443149006387 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 443149006388 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 443149006389 Transcriptional regulator [Transcription]; Region: LysR; COG0583 443149006390 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 443149006391 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 443149006392 dimerization interface [polypeptide binding]; other site 443149006393 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 443149006394 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 443149006395 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 443149006396 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443149006397 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443149006398 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 443149006399 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 443149006400 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 443149006401 CDP-diacylglycerol pyrophosphatase [Lipid metabolism]; Region: Cdh; COG2134 443149006402 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 443149006403 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 443149006404 active site residue [active] 443149006405 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 443149006406 active site residue [active] 443149006407 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 443149006408 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 443149006409 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443149006410 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443149006411 homodimer interface [polypeptide binding]; other site 443149006412 catalytic residue [active] 443149006413 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3196 443149006414 haloalkane dehalogenase; Provisional; Region: PRK00870 443149006415 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 443149006416 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 443149006417 active site 443149006418 catalytic tetrad [active] 443149006419 heat shock protein 90; Provisional; Region: PRK05218 443149006420 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443149006421 ATP binding site [chemical binding]; other site 443149006422 Mg2+ binding site [ion binding]; other site 443149006423 G-X-G motif; other site 443149006424 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 443149006425 Cutinase; Region: Cutinase; pfam01083 443149006426 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 443149006427 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 443149006428 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 443149006429 Uncharacterized conserved protein [Function unknown]; Region: COG0398 443149006430 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 443149006431 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 443149006432 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 443149006433 Uncharacterized conserved protein [Function unknown]; Region: COG2442 443149006434 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 443149006435 DNA binding site [nucleotide binding] 443149006436 active site 443149006437 Int/Topo IB signature motif; other site 443149006438 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 443149006439 DNA binding residues [nucleotide binding] 443149006440 Family description; Region: UvrD_C_2; pfam13538 443149006441 Uncharacterized conserved protein [Function unknown]; Region: COG2128 443149006442 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 443149006443 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 443149006444 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443149006445 putative PBP binding loops; other site 443149006446 ABC-ATPase subunit interface; other site 443149006447 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 443149006448 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443149006449 dimer interface [polypeptide binding]; other site 443149006450 conserved gate region; other site 443149006451 putative PBP binding loops; other site 443149006452 ABC-ATPase subunit interface; other site 443149006453 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 443149006454 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 443149006455 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 443149006456 Ligand Binding Site [chemical binding]; other site 443149006457 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 443149006458 Ligand Binding Site [chemical binding]; other site 443149006459 amino acid transporter; Region: 2A0306; TIGR00909 443149006460 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 443149006461 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 443149006462 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 443149006463 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443149006464 catalytic residue [active] 443149006465 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 443149006466 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443149006467 Amidinotransferase; Region: Amidinotransf; pfam02274 443149006468 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 443149006469 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 443149006470 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 443149006471 putative DNA binding site [nucleotide binding]; other site 443149006472 putative Zn2+ binding site [ion binding]; other site 443149006473 AsnC family; Region: AsnC_trans_reg; pfam01037 443149006474 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 443149006475 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 443149006476 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 443149006477 Walker A/P-loop; other site 443149006478 ATP binding site [chemical binding]; other site 443149006479 Q-loop/lid; other site 443149006480 ABC transporter signature motif; other site 443149006481 Walker B; other site 443149006482 D-loop; other site 443149006483 H-loop/switch region; other site 443149006484 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 443149006485 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 443149006486 Walker A/P-loop; other site 443149006487 ATP binding site [chemical binding]; other site 443149006488 Q-loop/lid; other site 443149006489 ABC transporter signature motif; other site 443149006490 Walker B; other site 443149006491 D-loop; other site 443149006492 H-loop/switch region; other site 443149006493 MarR family; Region: MarR; pfam01047 443149006494 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 443149006495 PE family; Region: PE; pfam00934 443149006496 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 443149006497 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443149006498 putative substrate translocation pore; other site 443149006499 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 443149006500 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 443149006501 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 443149006502 malate dehydrogenase; Provisional; Region: PRK13529 443149006503 Malic enzyme, N-terminal domain; Region: malic; pfam00390 443149006504 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 443149006505 NAD(P) binding site [chemical binding]; other site 443149006506 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443149006507 Major Facilitator Superfamily; Region: MFS_1; pfam07690 443149006508 putative substrate translocation pore; other site 443149006509 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443149006510 putative substrate translocation pore; other site 443149006511 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 443149006512 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 443149006513 dimer interface [polypeptide binding]; other site 443149006514 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443149006515 catalytic residue [active] 443149006516 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 443149006517 serine O-acetyltransferase; Region: cysE; TIGR01172 443149006518 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 443149006519 trimer interface [polypeptide binding]; other site 443149006520 active site 443149006521 substrate binding site [chemical binding]; other site 443149006522 CoA binding site [chemical binding]; other site 443149006523 hypothetical protein; Provisional; Region: PRK14851 443149006524 hypothetical protein; Validated; Region: PRK08223 443149006525 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 443149006526 ATP binding site [chemical binding]; other site 443149006527 substrate interface [chemical binding]; other site 443149006528 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 443149006529 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 443149006530 PE family; Region: PE; pfam00934 443149006531 DNA primase; Validated; Region: dnaG; PRK05667 443149006532 CHC2 zinc finger; Region: zf-CHC2; pfam01807 443149006533 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 443149006534 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 443149006535 active site 443149006536 metal binding site [ion binding]; metal-binding site 443149006537 interdomain interaction site; other site 443149006538 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 443149006539 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 443149006540 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 443149006541 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443149006542 Zn2+ binding site [ion binding]; other site 443149006543 Mg2+ binding site [ion binding]; other site 443149006544 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 443149006545 Repair protein; Region: Repair_PSII; pfam04536 443149006546 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 443149006547 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 443149006548 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 443149006549 Phosphoesterase family; Region: Phosphoesterase; pfam04185 443149006550 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 443149006551 Phosphoesterase family; Region: Phosphoesterase; pfam04185 443149006552 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 443149006553 Phosphoesterase family; Region: Phosphoesterase; pfam04185 443149006554 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149006555 PPE family; Region: PPE; pfam00823 443149006556 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 443149006557 Transposase; Region: HTH_Tnp_1; cl17663 443149006558 putative transposase OrfB; Reviewed; Region: PHA02517 443149006559 HTH-like domain; Region: HTH_21; pfam13276 443149006560 Integrase core domain; Region: rve; pfam00665 443149006561 Integrase core domain; Region: rve_3; pfam13683 443149006562 PPE family; Region: PPE; pfam00823 443149006563 PPE family; Region: PPE; pfam00823 443149006564 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149006565 PPE family; Region: PPE; pfam00823 443149006566 glycyl-tRNA synthetase; Provisional; Region: PRK04173 443149006567 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 443149006568 motif 1; other site 443149006569 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 443149006570 active site 443149006571 motif 2; other site 443149006572 motif 3; other site 443149006573 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 443149006574 anticodon binding site; other site 443149006575 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443149006576 dimerization interface [polypeptide binding]; other site 443149006577 putative DNA binding site [nucleotide binding]; other site 443149006578 putative Zn2+ binding site [ion binding]; other site 443149006579 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 443149006580 metal binding site 2 [ion binding]; metal-binding site 443149006581 putative DNA binding helix; other site 443149006582 metal binding site 1 [ion binding]; metal-binding site 443149006583 dimer interface [polypeptide binding]; other site 443149006584 structural Zn2+ binding site [ion binding]; other site 443149006585 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 443149006586 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 443149006587 catalytic residue [active] 443149006588 putative FPP diphosphate binding site; other site 443149006589 putative FPP binding hydrophobic cleft; other site 443149006590 dimer interface [polypeptide binding]; other site 443149006591 putative IPP diphosphate binding site; other site 443149006592 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 443149006593 Recombination protein O N terminal; Region: RecO_N; pfam11967 443149006594 Recombination protein O C terminal; Region: RecO_C; pfam02565 443149006595 amidase; Provisional; Region: PRK06061 443149006596 Amidase; Region: Amidase; pfam01425 443149006597 GTPase Era; Reviewed; Region: era; PRK00089 443149006598 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 443149006599 G1 box; other site 443149006600 GTP/Mg2+ binding site [chemical binding]; other site 443149006601 Switch I region; other site 443149006602 G2 box; other site 443149006603 Switch II region; other site 443149006604 G3 box; other site 443149006605 G4 box; other site 443149006606 G5 box; other site 443149006607 KH domain; Region: KH_2; pfam07650 443149006608 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 443149006609 Domain of unknown function DUF21; Region: DUF21; pfam01595 443149006610 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 443149006611 Transporter associated domain; Region: CorC_HlyC; smart01091 443149006612 metal-binding heat shock protein; Provisional; Region: PRK00016 443149006613 K homology RNA-binding domain; Region: KH; smart00322 443149006614 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 443149006615 PhoH-like protein; Region: PhoH; pfam02562 443149006616 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 443149006617 PE family; Region: PE; pfam00934 443149006618 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 443149006619 RNA methyltransferase, RsmE family; Region: TIGR00046 443149006620 chaperone protein DnaJ; Provisional; Region: PRK14278 443149006621 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 443149006622 HSP70 interaction site [polypeptide binding]; other site 443149006623 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 443149006624 Zn binding sites [ion binding]; other site 443149006625 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 443149006626 dimer interface [polypeptide binding]; other site 443149006627 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 443149006628 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 443149006629 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 443149006630 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 443149006631 Condensation domain; Region: Condensation; pfam00668 443149006632 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 443149006633 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 443149006634 acyl-activating enzyme (AAE) consensus motif; other site 443149006635 AMP binding site [chemical binding]; other site 443149006636 Condensation domain; Region: Condensation; pfam00668 443149006637 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 443149006638 Condensation domain; Region: Condensation; pfam00668 443149006639 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 443149006640 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 443149006641 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 443149006642 acyl-activating enzyme (AAE) consensus motif; other site 443149006643 AMP binding site [chemical binding]; other site 443149006644 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 443149006645 Condensation domain; Region: Condensation; pfam00668 443149006646 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 443149006647 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 443149006648 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443149006649 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 443149006650 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 443149006651 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 443149006652 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 443149006653 NADP binding site [chemical binding]; other site 443149006654 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 443149006655 active site 443149006656 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 443149006657 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 443149006658 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 443149006659 active site 443149006660 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 443149006661 Condensation domain; Region: Condensation; pfam00668 443149006662 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 443149006663 Nonribosomal peptide synthase; Region: NRPS; pfam08415 443149006664 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 443149006665 acyl-activating enzyme (AAE) consensus motif; other site 443149006666 AMP binding site [chemical binding]; other site 443149006667 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 443149006668 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 443149006669 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 443149006670 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 443149006671 acyl-activating enzyme (AAE) consensus motif; other site 443149006672 active site 443149006673 AMP binding site [chemical binding]; other site 443149006674 substrate binding site [chemical binding]; other site 443149006675 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 443149006676 salicylate synthase MbtI; Reviewed; Region: PRK07912 443149006677 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 443149006678 Predicted permease [General function prediction only]; Region: COG3329 443149006679 coproporphyrinogen III oxidase; Validated; Region: PRK05628 443149006680 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 443149006681 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 443149006682 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 443149006683 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 443149006684 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 443149006685 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 443149006686 Active Sites [active] 443149006687 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 443149006688 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 443149006689 putative active site [active] 443149006690 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 443149006691 putative active site [active] 443149006692 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 443149006693 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 443149006694 Predicted membrane protein [Function unknown]; Region: COG1297 443149006695 putative oligopeptide transporter, OPT family; Region: TIGR00733 443149006696 PE family; Region: PE; pfam00934 443149006697 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 443149006698 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 443149006699 Walker A/P-loop; other site 443149006700 ATP binding site [chemical binding]; other site 443149006701 Q-loop/lid; other site 443149006702 ABC transporter signature motif; other site 443149006703 Walker B; other site 443149006704 D-loop; other site 443149006705 H-loop/switch region; other site 443149006706 sulfate transport protein; Provisional; Region: cysT; CHL00187 443149006707 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443149006708 dimer interface [polypeptide binding]; other site 443149006709 conserved gate region; other site 443149006710 putative PBP binding loops; other site 443149006711 ABC-ATPase subunit interface; other site 443149006712 sulfate transport protein; Provisional; Region: cysT; CHL00187 443149006713 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443149006714 dimer interface [polypeptide binding]; other site 443149006715 conserved gate region; other site 443149006716 putative PBP binding loops; other site 443149006717 ABC-ATPase subunit interface; other site 443149006718 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 443149006719 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 443149006720 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 443149006721 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 443149006722 PknH-like extracellular domain; Region: PknH_C; pfam14032 443149006723 GTP-binding protein LepA; Provisional; Region: PRK05433 443149006724 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 443149006725 G1 box; other site 443149006726 putative GEF interaction site [polypeptide binding]; other site 443149006727 GTP/Mg2+ binding site [chemical binding]; other site 443149006728 Switch I region; other site 443149006729 G2 box; other site 443149006730 G3 box; other site 443149006731 Switch II region; other site 443149006732 G4 box; other site 443149006733 G5 box; other site 443149006734 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 443149006735 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 443149006736 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 443149006737 PemK-like protein; Region: PemK; pfam02452 443149006738 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 443149006739 FOG: CBS domain [General function prediction only]; Region: COG0517 443149006740 ribonuclease Z; Reviewed; Region: PRK00055 443149006741 PE family; Region: PE; pfam00934 443149006742 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 443149006743 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 443149006744 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 443149006745 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 443149006746 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 443149006747 Uncharacterized conserved protein [Function unknown]; Region: COG2308 443149006748 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 443149006749 hypothetical protein; Reviewed; Region: PRK07914 443149006750 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 443149006751 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 443149006752 Competence protein; Region: Competence; pfam03772 443149006753 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 443149006754 Helix-hairpin-helix motif; Region: HHH; pfam00633 443149006755 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 443149006756 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443149006757 Coenzyme A binding pocket [chemical binding]; other site 443149006758 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 443149006759 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 443149006760 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 443149006761 active site 443149006762 catalytic triad [active] 443149006763 oxyanion hole [active] 443149006764 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 443149006765 catalytic core [active] 443149006766 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 443149006767 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 443149006768 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 443149006769 active site 443149006770 (T/H)XGH motif; other site 443149006771 Methyltransferase domain; Region: Methyltransf_23; pfam13489 443149006772 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149006773 S-adenosylmethionine binding site [chemical binding]; other site 443149006774 Transposase; Region: DEDD_Tnp_IS110; pfam01548 443149006775 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 443149006776 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 443149006777 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 443149006778 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 443149006779 metal ion-dependent adhesion site (MIDAS); other site 443149006780 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 443149006781 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443149006782 Walker A motif; other site 443149006783 ATP binding site [chemical binding]; other site 443149006784 Walker B motif; other site 443149006785 arginine finger; other site 443149006786 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 443149006787 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 443149006788 putative catalytic cysteine [active] 443149006789 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 443149006790 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 443149006791 dimer interface [polypeptide binding]; other site 443149006792 decamer (pentamer of dimers) interface [polypeptide binding]; other site 443149006793 catalytic triad [active] 443149006794 peroxidatic and resolving cysteines [active] 443149006795 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 443149006796 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 443149006797 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149006798 PPE family; Region: PPE; pfam00823 443149006799 PE family; Region: PE; pfam00934 443149006800 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 443149006801 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 443149006802 ligand binding site [chemical binding]; other site 443149006803 flexible hinge region; other site 443149006804 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 443149006805 Mechanosensitive ion channel; Region: MS_channel; pfam00924 443149006806 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443149006807 dimerization interface [polypeptide binding]; other site 443149006808 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 443149006809 cyclase homology domain; Region: CHD; cd07302 443149006810 nucleotidyl binding site; other site 443149006811 metal binding site [ion binding]; metal-binding site 443149006812 dimer interface [polypeptide binding]; other site 443149006813 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 443149006814 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 443149006815 substrate binding site [chemical binding]; other site 443149006816 dimer interface [polypeptide binding]; other site 443149006817 ATP binding site [chemical binding]; other site 443149006818 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 443149006819 NAD synthetase; Reviewed; Region: nadE; PRK02628 443149006820 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 443149006821 multimer interface [polypeptide binding]; other site 443149006822 active site 443149006823 catalytic triad [active] 443149006824 protein interface 1 [polypeptide binding]; other site 443149006825 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 443149006826 homodimer interface [polypeptide binding]; other site 443149006827 NAD binding pocket [chemical binding]; other site 443149006828 ATP binding pocket [chemical binding]; other site 443149006829 Mg binding site [ion binding]; other site 443149006830 active-site loop [active] 443149006831 gamma-glutamyl kinase; Provisional; Region: PRK05429 443149006832 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 443149006833 nucleotide binding site [chemical binding]; other site 443149006834 homotetrameric interface [polypeptide binding]; other site 443149006835 putative phosphate binding site [ion binding]; other site 443149006836 putative allosteric binding site; other site 443149006837 PUA domain; Region: PUA; pfam01472 443149006838 GTPase CgtA; Reviewed; Region: obgE; PRK12296 443149006839 GTP1/OBG; Region: GTP1_OBG; pfam01018 443149006840 Obg GTPase; Region: Obg; cd01898 443149006841 G1 box; other site 443149006842 GTP/Mg2+ binding site [chemical binding]; other site 443149006843 Switch I region; other site 443149006844 G2 box; other site 443149006845 G3 box; other site 443149006846 Switch II region; other site 443149006847 G4 box; other site 443149006848 G5 box; other site 443149006849 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 443149006850 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 443149006851 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 443149006852 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 443149006853 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 443149006854 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 443149006855 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 443149006856 homodimer interface [polypeptide binding]; other site 443149006857 oligonucleotide binding site [chemical binding]; other site 443149006858 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 443149006859 active site 443149006860 multimer interface [polypeptide binding]; other site 443149006861 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 443149006862 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 443149006863 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 443149006864 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 443149006865 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 443149006866 active site 443149006867 HIGH motif; other site 443149006868 nucleotide binding site [chemical binding]; other site 443149006869 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 443149006870 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 443149006871 active site 443149006872 KMSKS motif; other site 443149006873 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 443149006874 tRNA binding surface [nucleotide binding]; other site 443149006875 anticodon binding site; other site 443149006876 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 443149006877 Uncharacterized conserved protein [Function unknown]; Region: COG3268 443149006878 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 443149006879 NAD(P) binding pocket [chemical binding]; other site 443149006880 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 443149006881 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 443149006882 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 443149006883 GTP binding site; other site 443149006884 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 443149006885 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 443149006886 TPP-binding site [chemical binding]; other site 443149006887 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 443149006888 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 443149006889 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 443149006890 dimer interface [polypeptide binding]; other site 443149006891 PYR/PP interface [polypeptide binding]; other site 443149006892 TPP binding site [chemical binding]; other site 443149006893 substrate binding site [chemical binding]; other site 443149006894 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 443149006895 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 443149006896 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443149006897 Walker A motif; other site 443149006898 ATP binding site [chemical binding]; other site 443149006899 Walker B motif; other site 443149006900 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 443149006901 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 443149006902 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 443149006903 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443149006904 Major Facilitator Superfamily; Region: MFS_1; pfam07690 443149006905 putative substrate translocation pore; other site 443149006906 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443149006907 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 443149006908 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 443149006909 oligomer interface [polypeptide binding]; other site 443149006910 active site residues [active] 443149006911 Clp protease; Region: CLP_protease; pfam00574 443149006912 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 443149006913 oligomer interface [polypeptide binding]; other site 443149006914 active site residues [active] 443149006915 trigger factor; Provisional; Region: tig; PRK01490 443149006916 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 443149006917 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 443149006918 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 443149006919 Beta-lactamase; Region: Beta-lactamase; pfam00144 443149006920 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 443149006921 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 443149006922 putative DNA binding site [nucleotide binding]; other site 443149006923 catalytic residue [active] 443149006924 putative H2TH interface [polypeptide binding]; other site 443149006925 putative catalytic residues [active] 443149006926 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 443149006927 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 443149006928 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 443149006929 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 443149006930 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 443149006931 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 443149006932 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 443149006933 Zn binding site [ion binding]; other site 443149006934 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 443149006935 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 443149006936 active site 443149006937 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 443149006938 apolar tunnel; other site 443149006939 heme binding site [chemical binding]; other site 443149006940 dimerization interface [polypeptide binding]; other site 443149006941 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 443149006942 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 443149006943 active site 443149006944 catalytic site [active] 443149006945 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 443149006946 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 443149006947 active site 443149006948 NAD-specific glutamate dehydrogenase [Amino acid transport and metabolism]; Region: COG2902 443149006949 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 443149006950 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 443149006951 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 443149006952 ABC transporter; Region: ABC_tran_2; pfam12848 443149006953 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 443149006954 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 443149006955 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 443149006956 dimer interface [polypeptide binding]; other site 443149006957 ssDNA binding site [nucleotide binding]; other site 443149006958 tetramer (dimer of dimers) interface [polypeptide binding]; other site 443149006959 glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355 443149006960 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 443149006961 putative acyl-acceptor binding pocket; other site 443149006962 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 443149006963 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 443149006964 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 443149006965 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 443149006966 putative acyl-acceptor binding pocket; other site 443149006967 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443149006968 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443149006969 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 443149006970 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 443149006971 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 443149006972 enoyl-CoA hydratase; Provisional; Region: PRK05870 443149006973 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443149006974 substrate binding site [chemical binding]; other site 443149006975 oxyanion hole (OAH) forming residues; other site 443149006976 trimer interface [polypeptide binding]; other site 443149006977 PE family; Region: PE; pfam00934 443149006978 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 443149006979 cyclase homology domain; Region: CHD; cd07302 443149006980 nucleotidyl binding site; other site 443149006981 metal binding site [ion binding]; metal-binding site 443149006982 dimer interface [polypeptide binding]; other site 443149006983 AAA ATPase domain; Region: AAA_16; pfam13191 443149006984 Predicted ATPase [General function prediction only]; Region: COG3903 443149006985 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443149006986 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443149006987 DNA binding residues [nucleotide binding] 443149006988 dimerization interface [polypeptide binding]; other site 443149006989 PE family; Region: PE; pfam00934 443149006990 TIGR00725 family protein; Region: TIGR00725 443149006991 thymidylate synthase; Provisional; Region: thyA; PRK00956 443149006992 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 443149006993 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 443149006994 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 443149006995 E3 interaction surface; other site 443149006996 lipoyl attachment site [posttranslational modification]; other site 443149006997 e3 binding domain; Region: E3_binding; pfam02817 443149006998 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 443149006999 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 443149007000 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 443149007001 alpha subunit interface [polypeptide binding]; other site 443149007002 TPP binding site [chemical binding]; other site 443149007003 heterodimer interface [polypeptide binding]; other site 443149007004 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 443149007005 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 443149007006 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 443149007007 tetramer interface [polypeptide binding]; other site 443149007008 TPP-binding site [chemical binding]; other site 443149007009 heterodimer interface [polypeptide binding]; other site 443149007010 phosphorylation loop region [posttranslational modification] 443149007011 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 443149007012 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 443149007013 putative active site [active] 443149007014 putative catalytic site [active] 443149007015 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149007016 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443149007017 active site 443149007018 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 443149007019 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 443149007020 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 443149007021 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 443149007022 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 443149007023 carboxyltransferase (CT) interaction site; other site 443149007024 biotinylation site [posttranslational modification]; other site 443149007025 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 443149007026 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 443149007027 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 443149007028 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 443149007029 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 443149007030 AMP-binding domain protein; Validated; Region: PRK08315 443149007031 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443149007032 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 443149007033 acyl-activating enzyme (AAE) consensus motif; other site 443149007034 acyl-activating enzyme (AAE) consensus motif; other site 443149007035 putative AMP binding site [chemical binding]; other site 443149007036 putative active site [active] 443149007037 putative CoA binding site [chemical binding]; other site 443149007038 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149007039 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149007040 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 443149007041 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 443149007042 classical (c) SDRs; Region: SDR_c; cd05233 443149007043 NAD(P) binding site [chemical binding]; other site 443149007044 active site 443149007045 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 443149007046 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 443149007047 catalytic site [active] 443149007048 putative active site [active] 443149007049 putative substrate binding site [chemical binding]; other site 443149007050 dimer interface [polypeptide binding]; other site 443149007051 Transposase, Mutator family; Region: Transposase_mut; pfam00872 443149007052 MULE transposase domain; Region: MULE; pfam10551 443149007053 Domain of unknown function (DUF4411); Region: DUF4411; pfam14367 443149007054 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443149007055 non-specific DNA binding site [nucleotide binding]; other site 443149007056 salt bridge; other site 443149007057 sequence-specific DNA binding site [nucleotide binding]; other site 443149007058 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 443149007059 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893 443149007060 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 443149007061 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 443149007062 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 443149007063 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 443149007064 PE family; Region: PE; pfam00934 443149007065 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 443149007066 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 443149007067 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 443149007068 catalytic triad [active] 443149007069 hypothetical protein; Provisional; Region: PRK07907 443149007070 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 443149007071 active site 443149007072 metal binding site [ion binding]; metal-binding site 443149007073 dimer interface [polypeptide binding]; other site 443149007074 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 443149007075 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 443149007076 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 443149007077 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 443149007078 phosphate binding site [ion binding]; other site 443149007079 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 443149007080 FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447 443149007081 putative active site [active] 443149007082 putative catalytic site [active] 443149007083 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 443149007084 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 443149007085 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 443149007086 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 443149007087 putative NAD(P) binding site [chemical binding]; other site 443149007088 active site 443149007089 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 443149007090 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 443149007091 active site 443149007092 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 443149007093 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 443149007094 putative active site [active] 443149007095 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 443149007096 Mrr N-terminal domain; Region: Mrr_N; pfam14338 443149007097 Restriction endonuclease; Region: Mrr_cat; pfam04471 443149007098 ERCC4 domain; Region: ERCC4; pfam02732 443149007099 Lsr2; Region: Lsr2; pfam11774 443149007100 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 443149007101 putative active site [active] 443149007102 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 443149007103 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 443149007104 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443149007105 catalytic residue [active] 443149007106 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 443149007107 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 443149007108 putative RNA binding site [nucleotide binding]; other site 443149007109 elongation factor P; Validated; Region: PRK00529 443149007110 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 443149007111 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 443149007112 RNA binding site [nucleotide binding]; other site 443149007113 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 443149007114 RNA binding site [nucleotide binding]; other site 443149007115 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 443149007116 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 443149007117 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 443149007118 active site 443149007119 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 443149007120 Dehydroquinase class II; Region: DHquinase_II; pfam01220 443149007121 trimer interface [polypeptide binding]; other site 443149007122 active site 443149007123 dimer interface [polypeptide binding]; other site 443149007124 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 443149007125 active site 443149007126 dimer interface [polypeptide binding]; other site 443149007127 metal binding site [ion binding]; metal-binding site 443149007128 shikimate kinase; Reviewed; Region: aroK; PRK00131 443149007129 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 443149007130 ADP binding site [chemical binding]; other site 443149007131 magnesium binding site [ion binding]; other site 443149007132 putative shikimate binding site; other site 443149007133 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 443149007134 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 443149007135 Tetramer interface [polypeptide binding]; other site 443149007136 active site 443149007137 FMN-binding site [chemical binding]; other site 443149007138 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 443149007139 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 443149007140 putative active site [active] 443149007141 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 443149007142 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 443149007143 oligomeric interface; other site 443149007144 putative active site [active] 443149007145 homodimer interface [polypeptide binding]; other site 443149007146 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402 443149007147 putative active site [active] 443149007148 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 443149007149 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 443149007150 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 443149007151 shikimate-5-dehydrogenase, fungal AROM-type; Region: Shik-DH-AROM; TIGR01809 443149007152 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 443149007153 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 443149007154 NAD(P) binding site [chemical binding]; other site 443149007155 shikimate binding site; other site 443149007156 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 443149007157 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 443149007158 dimerization interface [polypeptide binding]; other site 443149007159 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 443149007160 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 443149007161 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 443149007162 motif 1; other site 443149007163 active site 443149007164 motif 2; other site 443149007165 motif 3; other site 443149007166 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 443149007167 DHHA1 domain; Region: DHHA1; pfam02272 443149007168 Uncharacterized conserved protein [Function unknown]; Region: COG0432 443149007169 recombination factor protein RarA; Reviewed; Region: PRK13342 443149007170 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443149007171 Walker A motif; other site 443149007172 ATP binding site [chemical binding]; other site 443149007173 Walker B motif; other site 443149007174 arginine finger; other site 443149007175 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 443149007176 Predicted integral membrane protein [Function unknown]; Region: COG5473 443149007177 Protein of unknown function (DUF2652); Region: DUF2652; pfam10851 443149007178 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 443149007179 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 443149007180 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 443149007181 Walker A/P-loop; other site 443149007182 ATP binding site [chemical binding]; other site 443149007183 Q-loop/lid; other site 443149007184 ABC transporter signature motif; other site 443149007185 Walker B; other site 443149007186 D-loop; other site 443149007187 H-loop/switch region; other site 443149007188 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 443149007189 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 443149007190 ligand binding site [chemical binding]; other site 443149007191 flexible hinge region; other site 443149007192 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 443149007193 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 443149007194 ligand binding site [chemical binding]; other site 443149007195 flexible hinge region; other site 443149007196 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 443149007197 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 443149007198 active site 443149007199 nucleophile elbow; other site 443149007200 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 443149007201 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 443149007202 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 443149007203 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 443149007204 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 443149007205 Uncharacterized conserved protein [Function unknown]; Region: COG2308 443149007206 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 443149007207 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 443149007208 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 443149007209 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 443149007210 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 443149007211 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 443149007212 Transglutaminase/protease-like homologues; Region: TGc; smart00460 443149007213 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3801 443149007214 Predicted membrane protein [Function unknown]; Region: COG4129 443149007215 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 443149007216 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 443149007217 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 443149007218 dimer interface [polypeptide binding]; other site 443149007219 anticodon binding site; other site 443149007220 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 443149007221 homodimer interface [polypeptide binding]; other site 443149007222 motif 1; other site 443149007223 active site 443149007224 motif 2; other site 443149007225 GAD domain; Region: GAD; pfam02938 443149007226 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 443149007227 active site 443149007228 motif 3; other site 443149007229 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 443149007230 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 443149007231 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 443149007232 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 443149007233 putative hydrophobic ligand binding site [chemical binding]; other site 443149007234 protein interface [polypeptide binding]; other site 443149007235 gate; other site 443149007236 Predicted metalloprotease [General function prediction only]; Region: COG2321 443149007237 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 443149007238 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 443149007239 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 443149007240 active site 443149007241 metal binding site [ion binding]; metal-binding site 443149007242 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 443149007243 haloalkane dehalogenase; Provisional; Region: PRK03592 443149007244 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 443149007245 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 443149007246 dimer interface [polypeptide binding]; other site 443149007247 motif 1; other site 443149007248 active site 443149007249 motif 2; other site 443149007250 motif 3; other site 443149007251 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 443149007252 anticodon binding site; other site 443149007253 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 443149007254 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 443149007255 active site 443149007256 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 443149007257 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443149007258 Zn2+ binding site [ion binding]; other site 443149007259 Mg2+ binding site [ion binding]; other site 443149007260 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 443149007261 synthetase active site [active] 443149007262 NTP binding site [chemical binding]; other site 443149007263 metal binding site [ion binding]; metal-binding site 443149007264 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 443149007265 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 443149007266 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 443149007267 active site 443149007268 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 443149007269 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 443149007270 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 443149007271 Protein export membrane protein; Region: SecD_SecF; pfam02355 443149007272 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 443149007273 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 443149007274 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05886 443149007275 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 443149007276 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 443149007277 inhibitor-cofactor binding pocket; inhibition site 443149007278 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443149007279 catalytic residue [active] 443149007280 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 443149007281 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443149007282 acyl-activating enzyme (AAE) consensus motif; other site 443149007283 AMP binding site [chemical binding]; other site 443149007284 active site 443149007285 CoA binding site [chemical binding]; other site 443149007286 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 443149007287 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 443149007288 putative NAD(P) binding site [chemical binding]; other site 443149007289 active site 443149007290 putative substrate binding site [chemical binding]; other site 443149007291 PE family; Region: PE; pfam00934 443149007292 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 443149007293 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443149007294 Walker A motif; other site 443149007295 ATP binding site [chemical binding]; other site 443149007296 Walker B motif; other site 443149007297 arginine finger; other site 443149007298 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 443149007299 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 443149007300 RuvA N terminal domain; Region: RuvA_N; pfam01330 443149007301 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 443149007302 active site 443149007303 putative DNA-binding cleft [nucleotide binding]; other site 443149007304 dimer interface [polypeptide binding]; other site 443149007305 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 443149007306 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 443149007307 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 443149007308 putative active site [active] 443149007309 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 443149007310 Protein of unknown function DUF2617; Region: DUF2617; pfam10936 443149007311 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 443149007312 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 443149007313 Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only]; Region: COG4262 443149007314 Spermine/spermidine synthase; Region: Spermine_synth; pfam01564 443149007315 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 443149007316 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 443149007317 hypothetical protein; Validated; Region: PRK00110 443149007318 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 443149007319 predicted active site [active] 443149007320 catalytic triad [active] 443149007321 acyl-CoA thioesterase II; Region: tesB; TIGR00189 443149007322 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 443149007323 active site 443149007324 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 443149007325 catalytic triad [active] 443149007326 dimer interface [polypeptide binding]; other site 443149007327 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 443149007328 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 443149007329 active site 443149007330 multimer interface [polypeptide binding]; other site 443149007331 Pyridoxamine-phosphate oxidase [Coenzyme metabolism]; Region: PdxH; COG0259 443149007332 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 443149007333 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 443149007334 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149007335 PPE family; Region: PPE; pfam00823 443149007336 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149007337 PE-PPE domain; Region: PE-PPE; pfam08237 443149007338 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 443149007339 nudix motif; other site 443149007340 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443149007341 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 443149007342 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 443149007343 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 443149007344 putative acyl-acceptor binding pocket; other site 443149007345 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 443149007346 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 443149007347 nucleotide binding site/active site [active] 443149007348 HIT family signature motif; other site 443149007349 catalytic residue [active] 443149007350 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 443149007351 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 443149007352 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 443149007353 active site 443149007354 dimer interface [polypeptide binding]; other site 443149007355 motif 1; other site 443149007356 motif 2; other site 443149007357 motif 3; other site 443149007358 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 443149007359 anticodon binding site; other site 443149007360 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 443149007361 phosphate binding site [ion binding]; other site 443149007362 PE family; Region: PE; pfam00934 443149007363 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4762 443149007364 Helix-turn-helix domain; Region: HTH_20; pfam12840 443149007365 Predicted transcriptional regulator [Transcription]; Region: COG2345 443149007366 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 443149007367 Predicted transcriptional regulator [Transcription]; Region: COG2345 443149007368 Helix-turn-helix domain; Region: HTH_20; pfam12840 443149007369 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149007370 S-adenosylmethionine binding site [chemical binding]; other site 443149007371 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 443149007372 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 443149007373 Ligand Binding Site [chemical binding]; other site 443149007374 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 443149007375 Ligand Binding Site [chemical binding]; other site 443149007376 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 443149007377 Ligand Binding Site [chemical binding]; other site 443149007378 Universal stress protein family; Region: Usp; pfam00582 443149007379 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 443149007380 active site 443149007381 Peptidase family M50; Region: Peptidase_M50; pfam02163 443149007382 putative substrate binding region [chemical binding]; other site 443149007383 FOG: CBS domain [General function prediction only]; Region: COG0517 443149007384 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 443149007385 FOG: CBS domain [General function prediction only]; Region: COG0517 443149007386 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 443149007387 peptide chain release factor 1; Provisional; Region: PRK04011 443149007388 SHS2 domain protein implicated in nucleic acid metabolism [General function prediction only]; Region: COG1371 443149007389 Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690 443149007390 hypothetical protein; Reviewed; Region: PRK09588 443149007391 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 443149007392 Hemerythrin-like domain; Region: Hr-like; cd12108 443149007393 Fe binding site [ion binding]; other site 443149007394 PE family; Region: PE; pfam00934 443149007395 Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cd00227 443149007396 P-loop motif; other site 443149007397 ATP binding site [chemical binding]; other site 443149007398 Chloramphenicol (Cm) binding site [chemical binding]; other site 443149007399 catalytic residue [active] 443149007400 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 443149007401 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 443149007402 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 443149007403 anti sigma factor interaction site; other site 443149007404 regulatory phosphorylation site [posttranslational modification]; other site 443149007405 hypothetical protein; Provisional; Region: PRK02237 443149007406 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443149007407 Transcriptional regulators [Transcription]; Region: MarR; COG1846 443149007408 putative DNA binding site [nucleotide binding]; other site 443149007409 putative Zn2+ binding site [ion binding]; other site 443149007410 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 443149007411 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443149007412 putative metal binding site [ion binding]; other site 443149007413 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443149007414 dimerization interface [polypeptide binding]; other site 443149007415 putative DNA binding site [nucleotide binding]; other site 443149007416 putative Zn2+ binding site [ion binding]; other site 443149007417 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 443149007418 arsenical-resistance protein; Region: acr3; TIGR00832 443149007419 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 443149007420 Low molecular weight phosphatase family; Region: LMWPc; cd00115 443149007421 active site 443149007422 Protein of unknown function (DUF3018); Region: DUF3018; pfam11455 443149007423 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 443149007424 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 443149007425 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 443149007426 active site 443149007427 DNA binding site [nucleotide binding] 443149007428 Int/Topo IB signature motif; other site 443149007429 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 443149007430 ParB-like nuclease domain; Region: ParBc; cl02129 443149007431 Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653 443149007432 Phage capsid family; Region: Phage_capsid; pfam05065 443149007433 Phage head maturation protease [General function prediction only]; Region: COG3740 443149007434 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: COG3747 443149007435 Protein of unknown function (DUF3631); Region: DUF3631; pfam12307 443149007436 Protein of unknown function (DUF2742); Region: DUF2742; pfam10888 443149007437 DNA binding domain, excisionase family; Region: excise; TIGR01764 443149007438 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 443149007439 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 443149007440 active site 443149007441 catalytic residues [active] 443149007442 DNA binding site [nucleotide binding] 443149007443 Int/Topo IB signature motif; other site 443149007444 Transposase, Mutator family; Region: Transposase_mut; pfam00872 443149007445 MULE transposase domain; Region: MULE; pfam10551 443149007446 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 443149007447 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 443149007448 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443149007449 Coenzyme A binding pocket [chemical binding]; other site 443149007450 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 443149007451 hypothetical protein; Provisional; Region: PRK14059 443149007452 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 443149007453 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443149007454 TAP-like protein; Region: Abhydrolase_4; pfam08386 443149007455 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 443149007456 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 443149007457 SelR domain; Region: SelR; pfam01641 443149007458 Methyltransferase domain; Region: Methyltransf_31; pfam13847 443149007459 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149007460 S-adenosylmethionine binding site [chemical binding]; other site 443149007461 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 443149007462 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 443149007463 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 443149007464 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 443149007465 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 443149007466 substrate binding site [chemical binding]; other site 443149007467 active site 443149007468 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443149007469 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 443149007470 substrate binding site [chemical binding]; other site 443149007471 oxyanion hole (OAH) forming residues; other site 443149007472 trimer interface [polypeptide binding]; other site 443149007473 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 443149007474 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 443149007475 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 443149007476 catalytic site [active] 443149007477 putative active site [active] 443149007478 putative substrate binding site [chemical binding]; other site 443149007479 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 443149007480 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 443149007481 TPP-binding site; other site 443149007482 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 443149007483 PYR/PP interface [polypeptide binding]; other site 443149007484 dimer interface [polypeptide binding]; other site 443149007485 TPP binding site [chemical binding]; other site 443149007486 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 443149007487 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 443149007488 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 443149007489 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 443149007490 transmembrane helices; other site 443149007491 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 443149007492 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 443149007493 transmembrane helices; other site 443149007494 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 443149007495 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 443149007496 Walker A/P-loop; other site 443149007497 ATP binding site [chemical binding]; other site 443149007498 Q-loop/lid; other site 443149007499 ABC transporter signature motif; other site 443149007500 Walker B; other site 443149007501 D-loop; other site 443149007502 H-loop/switch region; other site 443149007503 TRAM domain; Region: TRAM; cl01282 443149007504 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 443149007505 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 443149007506 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 443149007507 TrkA-N domain; Region: TrkA_N; pfam02254 443149007508 TrkA-C domain; Region: TrkA_C; pfam02080 443149007509 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 443149007510 TrkA-N domain; Region: TrkA_N; pfam02254 443149007511 TrkA-C domain; Region: TrkA_C; pfam02080 443149007512 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 443149007513 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 443149007514 generic binding surface II; other site 443149007515 ssDNA binding site; other site 443149007516 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 443149007517 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 443149007518 trimer interface [polypeptide binding]; other site 443149007519 active site 443149007520 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 443149007521 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 443149007522 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 443149007523 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 443149007524 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 443149007525 active site 443149007526 dimerization interface [polypeptide binding]; other site 443149007527 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 443149007528 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 443149007529 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 443149007530 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443149007531 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 443149007532 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443149007533 DNA binding residues [nucleotide binding] 443149007534 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 443149007535 homotrimer interaction site [polypeptide binding]; other site 443149007536 putative active site [active] 443149007537 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502 443149007538 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 443149007539 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 443149007540 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 443149007541 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 443149007542 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 443149007543 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443149007544 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 443149007545 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443149007546 DNA binding residues [nucleotide binding] 443149007547 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 443149007548 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 443149007549 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 443149007550 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 443149007551 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 443149007552 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 443149007553 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 443149007554 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443149007555 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 443149007556 PAC2 family; Region: PAC2; pfam09754 443149007557 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443149007558 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 443149007559 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 443149007560 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 443149007561 heme-binding site [chemical binding]; other site 443149007562 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 443149007563 ATP cone domain; Region: ATP-cone; pfam03477 443149007564 LysM domain; Region: LysM; pfam01476 443149007565 LexA repressor; Validated; Region: PRK00215 443149007566 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 443149007567 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 443149007568 Catalytic site [active] 443149007569 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 443149007570 LGFP repeat; Region: LGFP; pfam08310 443149007571 LGFP repeat; Region: LGFP; pfam08310 443149007572 LGFP repeat; Region: LGFP; pfam08310 443149007573 LGFP repeat; Region: LGFP; pfam08310 443149007574 LGFP repeat; Region: LGFP; pfam08310 443149007575 Integral membrane protein TerC family; Region: TerC; cl10468 443149007576 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149007577 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443149007578 active site 443149007579 GTPases [General function prediction only]; Region: HflX; COG2262 443149007580 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 443149007581 HflX GTPase family; Region: HflX; cd01878 443149007582 G1 box; other site 443149007583 GTP/Mg2+ binding site [chemical binding]; other site 443149007584 Switch I region; other site 443149007585 G2 box; other site 443149007586 G3 box; other site 443149007587 Switch II region; other site 443149007588 G4 box; other site 443149007589 G5 box; other site 443149007590 diaminopimelate epimerase; Region: DapF; TIGR00652 443149007591 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 443149007592 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 443149007593 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 443149007594 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 443149007595 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 443149007596 active site 443149007597 metal binding site [ion binding]; metal-binding site 443149007598 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 443149007599 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 443149007600 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 443149007601 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 443149007602 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 443149007603 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443149007604 FeS/SAM binding site; other site 443149007605 TRAM domain; Region: TRAM; cl01282 443149007606 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443149007607 FeS/SAM binding site; other site 443149007608 Uncharacterized protein conserved in bacteria [General function prediction only]; Region: OraA; COG2137 443149007609 DNA recombination protein RecA; Reviewed; Region: recA; PRK09519 443149007610 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 443149007611 hexamer interface [polypeptide binding]; other site 443149007612 Walker A motif; other site 443149007613 ATP binding site [chemical binding]; other site 443149007614 Walker B motif; other site 443149007615 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 443149007616 protein-splicing catalytic site; other site 443149007617 thioester formation/cholesterol transfer; other site 443149007618 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 443149007619 recA bacterial DNA recombination protein; Region: RecA; cl17211 443149007620 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 443149007621 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 443149007622 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 443149007623 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 443149007624 Limonene-1,2-epoxide hydrolase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LimA; COG4308 443149007625 PE family; Region: PE; pfam00934 443149007626 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 443149007627 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 443149007628 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443149007629 non-specific DNA binding site [nucleotide binding]; other site 443149007630 salt bridge; other site 443149007631 sequence-specific DNA binding site [nucleotide binding]; other site 443149007632 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 443149007633 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443149007634 Coenzyme A binding pocket [chemical binding]; other site 443149007635 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 443149007636 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 443149007637 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 443149007638 Uncharacterized conserved protein [Function unknown]; Region: COG1359 443149007639 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 443149007640 classical (c) SDRs; Region: SDR_c; cd05233 443149007641 NAD(P) binding site [chemical binding]; other site 443149007642 active site 443149007643 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 443149007644 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 443149007645 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 443149007646 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 443149007647 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 443149007648 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 443149007649 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 443149007650 dimer interface [polypeptide binding]; other site 443149007651 active site 443149007652 catalytic residue [active] 443149007653 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 443149007654 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 443149007655 HsdM N-terminal domain; Region: HsdM_N; pfam12161 443149007656 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 443149007657 Methyltransferase domain; Region: Methyltransf_26; pfam13659 443149007658 putative transposase OrfB; Reviewed; Region: PHA02517 443149007659 HTH-like domain; Region: HTH_21; pfam13276 443149007660 Integrase core domain; Region: rve; pfam00665 443149007661 Integrase core domain; Region: rve_3; pfam13683 443149007662 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 443149007663 Transposase; Region: HTH_Tnp_1; cl17663 443149007664 HsdM N-terminal domain; Region: HsdM_N; pfam12161 443149007665 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 443149007666 putative active site [active] 443149007667 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 443149007668 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 443149007669 putative active site [active] 443149007670 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 443149007671 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 443149007672 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 443149007673 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 443149007674 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 443149007675 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 443149007676 folate binding site [chemical binding]; other site 443149007677 NADP+ binding site [chemical binding]; other site 443149007678 thymidylate synthase; Reviewed; Region: thyA; PRK01827 443149007679 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 443149007680 dimerization interface [polypeptide binding]; other site 443149007681 active site 443149007682 Dienelactone hydrolase family; Region: DLH; pfam01738 443149007683 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 443149007684 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 443149007685 classical (c) SDRs; Region: SDR_c; cd05233 443149007686 NAD(P) binding site [chemical binding]; other site 443149007687 active site 443149007688 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149007689 PPE family; Region: PPE; pfam00823 443149007690 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 443149007691 PE family; Region: PE; pfam00934 443149007692 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 443149007693 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149007694 PPE family; Region: PPE; pfam00823 443149007695 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 443149007696 dihydrodipicolinate reductase; Provisional; Region: PRK00048 443149007697 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 443149007698 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 443149007699 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 443149007700 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443149007701 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 443149007702 Coenzyme A binding pocket [chemical binding]; other site 443149007703 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 443149007704 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 443149007705 FMN-binding pocket [chemical binding]; other site 443149007706 flavin binding motif; other site 443149007707 phosphate binding motif [ion binding]; other site 443149007708 beta-alpha-beta structure motif; other site 443149007709 NAD binding pocket [chemical binding]; other site 443149007710 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443149007711 catalytic loop [active] 443149007712 iron binding site [ion binding]; other site 443149007713 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 443149007714 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 443149007715 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 443149007716 hydrophobic ligand binding site; other site 443149007717 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 443149007718 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443149007719 putative DNA binding site [nucleotide binding]; other site 443149007720 putative Zn2+ binding site [ion binding]; other site 443149007721 AsnC family; Region: AsnC_trans_reg; pfam01037 443149007722 alanine dehydrogenase; Region: alaDH; TIGR00518 443149007723 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 443149007724 hexamer interface [polypeptide binding]; other site 443149007725 ligand binding site [chemical binding]; other site 443149007726 putative active site [active] 443149007727 NAD(P) binding site [chemical binding]; other site 443149007728 Nitronate monooxygenase; Region: NMO; pfam03060 443149007729 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 443149007730 FMN binding site [chemical binding]; other site 443149007731 substrate binding site [chemical binding]; other site 443149007732 putative catalytic residue [active] 443149007733 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 443149007734 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 443149007735 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 443149007736 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 443149007737 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 443149007738 oligomer interface [polypeptide binding]; other site 443149007739 RNA binding site [nucleotide binding]; other site 443149007740 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 443149007741 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 443149007742 RNase E interface [polypeptide binding]; other site 443149007743 trimer interface [polypeptide binding]; other site 443149007744 active site 443149007745 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 443149007746 putative nucleic acid binding region [nucleotide binding]; other site 443149007747 G-X-X-G motif; other site 443149007748 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 443149007749 RNA binding site [nucleotide binding]; other site 443149007750 domain interface; other site 443149007751 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 443149007752 16S/18S rRNA binding site [nucleotide binding]; other site 443149007753 S13e-L30e interaction site [polypeptide binding]; other site 443149007754 25S rRNA binding site [nucleotide binding]; other site 443149007755 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 443149007756 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 443149007757 active site 443149007758 Riboflavin kinase; Region: Flavokinase; pfam01687 443149007759 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 443149007760 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 443149007761 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 443149007762 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443149007763 putative DNA binding site [nucleotide binding]; other site 443149007764 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 443149007765 FeoA domain; Region: FeoA; pfam04023 443149007766 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149007767 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443149007768 active site 443149007769 lipid-transfer protein; Provisional; Region: PRK08256 443149007770 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 443149007771 active site 443149007772 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 443149007773 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 443149007774 Probable transposase; Region: OrfB_IS605; pfam01385 443149007775 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 443149007776 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 443149007777 catalytic residues [active] 443149007778 catalytic nucleophile [active] 443149007779 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 443149007780 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 443149007781 RNA binding site [nucleotide binding]; other site 443149007782 active site 443149007783 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 443149007784 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 443149007785 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 443149007786 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 443149007787 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 443149007788 active site 443149007789 metal binding site [ion binding]; metal-binding site 443149007790 Uncharacterized conserved protein [Function unknown]; Region: COG4717 443149007791 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 443149007792 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 443149007793 Predicted acyl esterases [General function prediction only]; Region: COG2936 443149007794 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 443149007795 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 443149007796 Uncharacterized conserved protein [Function unknown]; Region: COG5586 443149007797 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 443149007798 Integrase core domain; Region: rve; pfam00665 443149007799 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 443149007800 Transposase; Region: DDE_Tnp_ISL3; pfam01610 443149007801 Helix-turn-helix domain; Region: HTH_28; pfam13518 443149007802 Winged helix-turn helix; Region: HTH_29; pfam13551 443149007803 Integrase core domain; Region: rve; pfam00665 443149007804 Integrase core domain; Region: rve_3; pfam13683 443149007805 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 443149007806 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 443149007807 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 443149007808 Transposase; Region: HTH_Tnp_1; cl17663 443149007809 putative transposase OrfB; Reviewed; Region: PHA02517 443149007810 HTH-like domain; Region: HTH_21; pfam13276 443149007811 Integrase core domain; Region: rve; pfam00665 443149007812 Integrase core domain; Region: rve_3; pfam13683 443149007813 CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cl17438 443149007814 CRISPR/Cas system-associated RAMP superfamily protein Csm3; Region: Csm3_III-A; cd09684 443149007815 CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cd09647 443149007816 Predicted CRISPR-associated polymerase [Defense mechanisms]; Region: COG1353 443149007817 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 443149007818 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 443149007819 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4293 443149007820 Uncharacterized conserved protein [Function unknown]; Region: COG2253 443149007821 Protein of unknown function (DUF2005); Region: DUF2005; pfam09407 443149007822 Domain of unknown function (DUF1802); Region: DUF1802; cl01755 443149007823 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 443149007824 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 443149007825 putative active site [active] 443149007826 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 443149007827 enoyl-CoA hydratase; Provisional; Region: PRK06190 443149007828 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443149007829 substrate binding site [chemical binding]; other site 443149007830 oxyanion hole (OAH) forming residues; other site 443149007831 trimer interface [polypeptide binding]; other site 443149007832 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 443149007833 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 443149007834 Walker A/P-loop; other site 443149007835 ATP binding site [chemical binding]; other site 443149007836 Q-loop/lid; other site 443149007837 ABC transporter signature motif; other site 443149007838 Walker B; other site 443149007839 D-loop; other site 443149007840 H-loop/switch region; other site 443149007841 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 443149007842 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 443149007843 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 443149007844 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443149007845 dimer interface [polypeptide binding]; other site 443149007846 conserved gate region; other site 443149007847 putative PBP binding loops; other site 443149007848 ABC-ATPase subunit interface; other site 443149007849 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 443149007850 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443149007851 dimer interface [polypeptide binding]; other site 443149007852 conserved gate region; other site 443149007853 putative PBP binding loops; other site 443149007854 ABC-ATPase subunit interface; other site 443149007855 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 443149007856 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 443149007857 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 443149007858 DHH family; Region: DHH; pfam01368 443149007859 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 443149007860 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 443149007861 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 443149007862 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 443149007863 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 443149007864 G1 box; other site 443149007865 putative GEF interaction site [polypeptide binding]; other site 443149007866 GTP/Mg2+ binding site [chemical binding]; other site 443149007867 Switch I region; other site 443149007868 G2 box; other site 443149007869 G3 box; other site 443149007870 Switch II region; other site 443149007871 G4 box; other site 443149007872 G5 box; other site 443149007873 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 443149007874 Translation-initiation factor 2; Region: IF-2; pfam11987 443149007875 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 443149007876 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189 443149007877 putative RNA binding cleft [nucleotide binding]; other site 443149007878 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 443149007879 NusA N-terminal domain; Region: NusA_N; pfam08529 443149007880 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 443149007881 RNA binding site [nucleotide binding]; other site 443149007882 homodimer interface [polypeptide binding]; other site 443149007883 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 443149007884 G-X-X-G motif; other site 443149007885 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 443149007886 G-X-X-G motif; other site 443149007887 ribosome maturation protein RimP; Reviewed; Region: PRK00092 443149007888 Sm and related proteins; Region: Sm_like; cl00259 443149007889 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 443149007890 putative oligomer interface [polypeptide binding]; other site 443149007891 putative RNA binding site [nucleotide binding]; other site 443149007892 Mitochondrial ATP synthase g subunit; Region: ATP-synt_G; pfam04718 443149007893 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 443149007894 dinuclear metal binding motif [ion binding]; other site 443149007895 prolyl-tRNA synthetase; Provisional; Region: PRK09194 443149007896 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 443149007897 dimer interface [polypeptide binding]; other site 443149007898 motif 1; other site 443149007899 active site 443149007900 motif 2; other site 443149007901 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 443149007902 putative deacylase active site [active] 443149007903 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 443149007904 active site 443149007905 motif 3; other site 443149007906 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 443149007907 anticodon binding site; other site 443149007908 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443149007909 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 443149007910 putative substrate translocation pore; other site 443149007911 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 443149007912 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 443149007913 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 443149007914 homodimer interface [polypeptide binding]; other site 443149007915 active site 443149007916 SAM binding site [chemical binding]; other site 443149007917 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 443149007918 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 443149007919 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 443149007920 catalytic triad [active] 443149007921 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 443149007922 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 443149007923 homodimer interface [polypeptide binding]; other site 443149007924 Walker A motif; other site 443149007925 ATP binding site [chemical binding]; other site 443149007926 hydroxycobalamin binding site [chemical binding]; other site 443149007927 Walker B motif; other site 443149007928 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 443149007929 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443149007930 Walker A motif; other site 443149007931 ATP binding site [chemical binding]; other site 443149007932 Walker B motif; other site 443149007933 arginine finger; other site 443149007934 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 443149007935 metal ion-dependent adhesion site (MIDAS); other site 443149007936 Predicted acyltransferase [General function prediction only]; Region: ElaA; COG2153 443149007937 malate:quinone oxidoreductase; Validated; Region: PRK05257 443149007938 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 443149007939 PE family; Region: PE; pfam00934 443149007940 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 443149007941 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 443149007942 mycothione reductase; Reviewed; Region: PRK07846 443149007943 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 443149007944 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443149007945 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 443149007946 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 443149007947 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 443149007948 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 443149007949 short chain dehydrogenase; Provisional; Region: PRK06057 443149007950 classical (c) SDRs; Region: SDR_c; cd05233 443149007951 NAD(P) binding site [chemical binding]; other site 443149007952 active site 443149007953 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 443149007954 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 443149007955 NAD(P) binding site [chemical binding]; other site 443149007956 catalytic residues [active] 443149007957 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 443149007958 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 443149007959 catalytic triad [active] 443149007960 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 443149007961 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 443149007962 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 443149007963 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 443149007964 active site 443149007965 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 443149007966 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 443149007967 putative active site [active] 443149007968 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 443149007969 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 443149007970 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 443149007971 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 443149007972 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 443149007973 Predicted acetyltransferase [General function prediction only]; Region: COG3393 443149007974 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 443149007975 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 443149007976 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 443149007977 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 443149007978 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 443149007979 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 443149007980 active site 443149007981 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 443149007982 protein binding site [polypeptide binding]; other site 443149007983 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 443149007984 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 443149007985 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 443149007986 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 443149007987 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 443149007988 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 443149007989 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 443149007990 Fasciclin domain; Region: Fasciclin; pfam02469 443149007991 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 443149007992 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 443149007993 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 443149007994 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 443149007995 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 443149007996 catalytic residues [active] 443149007997 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 443149007998 Fasciclin domain; Region: Fasciclin; pfam02469 443149007999 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 443149008000 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 443149008001 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 443149008002 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 443149008003 catalytic residues [active] 443149008004 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 443149008005 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443149008006 FeS/SAM binding site; other site 443149008007 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 443149008008 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 443149008009 ribosome recycling factor; Reviewed; Region: frr; PRK00083 443149008010 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 443149008011 hinge region; other site 443149008012 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 443149008013 putative nucleotide binding site [chemical binding]; other site 443149008014 uridine monophosphate binding site [chemical binding]; other site 443149008015 homohexameric interface [polypeptide binding]; other site 443149008016 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 443149008017 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443149008018 DNA binding site [nucleotide binding] 443149008019 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 443149008020 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 443149008021 Probable transposase; Region: OrfB_IS605; pfam01385 443149008022 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 443149008023 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 443149008024 catalytic residues [active] 443149008025 catalytic nucleophile [active] 443149008026 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 443149008027 MarR family; Region: MarR; pfam01047 443149008028 amidase; Provisional; Region: PRK07869 443149008029 Amidase; Region: Amidase; pfam01425 443149008030 elongation factor Ts; Provisional; Region: tsf; PRK09377 443149008031 UBA/TS-N domain; Region: UBA; pfam00627 443149008032 Elongation factor TS; Region: EF_TS; pfam00889 443149008033 Elongation factor TS; Region: EF_TS; pfam00889 443149008034 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 443149008035 rRNA interaction site [nucleotide binding]; other site 443149008036 S8 interaction site; other site 443149008037 putative laminin-1 binding site; other site 443149008038 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 443149008039 Peptidase family M23; Region: Peptidase_M23; pfam01551 443149008040 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149008041 PPE family; Region: PPE; pfam00823 443149008042 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 443149008043 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 443149008044 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 443149008045 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 443149008046 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 443149008047 active site 443149008048 DNA binding site [nucleotide binding] 443149008049 Int/Topo IB signature motif; other site 443149008050 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 443149008051 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 443149008052 FAD binding pocket [chemical binding]; other site 443149008053 FAD binding motif [chemical binding]; other site 443149008054 phosphate binding motif [ion binding]; other site 443149008055 NAD binding pocket [chemical binding]; other site 443149008056 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 443149008057 DNA protecting protein DprA; Region: dprA; TIGR00732 443149008058 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 443149008059 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 443149008060 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443149008061 Walker A motif; other site 443149008062 ATP binding site [chemical binding]; other site 443149008063 Walker B motif; other site 443149008064 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 443149008065 hypothetical protein; Reviewed; Region: PRK12497 443149008066 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 443149008067 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 443149008068 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 443149008069 putative molybdopterin cofactor binding site [chemical binding]; other site 443149008070 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 443149008071 putative molybdopterin cofactor binding site; other site 443149008072 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 443149008073 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 443149008074 RNA/DNA hybrid binding site [nucleotide binding]; other site 443149008075 active site 443149008076 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 443149008077 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 443149008078 Catalytic site [active] 443149008079 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 443149008080 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 443149008081 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 443149008082 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 443149008083 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 443149008084 RimM N-terminal domain; Region: RimM; pfam01782 443149008085 hypothetical protein; Provisional; Region: PRK02821 443149008086 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 443149008087 G-X-X-G motif; other site 443149008088 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 443149008089 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 443149008090 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 443149008091 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 443149008092 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149008093 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149008094 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 443149008095 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 443149008096 active site 443149008097 putative substrate binding pocket [chemical binding]; other site 443149008098 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 443149008099 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 443149008100 Catalytic domain of Protein Kinases; Region: PKc; cd00180 443149008101 active site 443149008102 ATP binding site [chemical binding]; other site 443149008103 substrate binding site [chemical binding]; other site 443149008104 activation loop (A-loop); other site 443149008105 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 443149008106 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 443149008107 active site 443149008108 signal recognition particle protein; Provisional; Region: PRK10867 443149008109 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 443149008110 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 443149008111 P loop; other site 443149008112 GTP binding site [chemical binding]; other site 443149008113 Signal peptide binding domain; Region: SRP_SPB; pfam02978 443149008114 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 443149008115 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 443149008116 ATP binding site [chemical binding]; other site 443149008117 putative Mg++ binding site [ion binding]; other site 443149008118 PII uridylyl-transferase; Provisional; Region: PRK03381 443149008119 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 443149008120 metal binding triad; other site 443149008121 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 443149008122 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443149008123 Zn2+ binding site [ion binding]; other site 443149008124 Mg2+ binding site [ion binding]; other site 443149008125 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 443149008126 Nitrogen regulatory protein P-II; Region: P-II; smart00938 443149008127 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 443149008128 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 443149008129 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 443149008130 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 443149008131 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 443149008132 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 443149008133 Walker A/P-loop; other site 443149008134 ATP binding site [chemical binding]; other site 443149008135 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 443149008136 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 443149008137 ABC transporter signature motif; other site 443149008138 Walker B; other site 443149008139 D-loop; other site 443149008140 H-loop/switch region; other site 443149008141 acylphosphatase; Provisional; Region: PRK14422 443149008142 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 443149008143 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 443149008144 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 443149008145 DNA binding site [nucleotide binding] 443149008146 catalytic residue [active] 443149008147 H2TH interface [polypeptide binding]; other site 443149008148 putative catalytic residues [active] 443149008149 turnover-facilitating residue; other site 443149008150 intercalation triad [nucleotide binding]; other site 443149008151 8OG recognition residue [nucleotide binding]; other site 443149008152 putative reading head residues; other site 443149008153 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 443149008154 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 443149008155 ribonuclease III; Reviewed; Region: rnc; PRK00102 443149008156 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 443149008157 dimerization interface [polypeptide binding]; other site 443149008158 active site 443149008159 metal binding site [ion binding]; metal-binding site 443149008160 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 443149008161 dsRNA binding site [nucleotide binding]; other site 443149008162 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 443149008163 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 443149008164 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 443149008165 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 443149008166 acyl-CoA synthetase; Validated; Region: PRK05850 443149008167 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 443149008168 acyl-activating enzyme (AAE) consensus motif; other site 443149008169 active site 443149008170 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 443149008171 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 443149008172 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 443149008173 active site 443149008174 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 443149008175 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 443149008176 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 443149008177 NADP binding site [chemical binding]; other site 443149008178 KR domain; Region: KR; pfam08659 443149008179 active site 443149008180 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 443149008181 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 443149008182 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 443149008183 active site 443149008184 Acyl transferase domain; Region: Acyl_transf_1; cl08282 443149008185 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 443149008186 KR domain; Region: KR; pfam08659 443149008187 NADP binding site [chemical binding]; other site 443149008188 active site 443149008189 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 443149008190 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 443149008191 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 443149008192 active site 443149008193 Acyl transferase domain; Region: Acyl_transf_1; cl08282 443149008194 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 443149008195 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443149008196 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 443149008197 Enoylreductase; Region: PKS_ER; smart00829 443149008198 NAD(P) binding site [chemical binding]; other site 443149008199 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 443149008200 KR domain; Region: KR; pfam08659 443149008201 putative NADP binding site [chemical binding]; other site 443149008202 active site 443149008203 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 443149008204 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 443149008205 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 443149008206 active site 443149008207 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 443149008208 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 443149008209 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 443149008210 KR domain; Region: KR; pfam08659 443149008211 putative NADP binding site [chemical binding]; other site 443149008212 active site 443149008213 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 443149008214 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 443149008215 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 443149008216 active site 443149008217 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 443149008218 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 443149008219 Condensation domain; Region: Condensation; pfam00668 443149008220 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 443149008221 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443149008222 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 443149008223 Walker A/P-loop; other site 443149008224 ATP binding site [chemical binding]; other site 443149008225 Q-loop/lid; other site 443149008226 ABC transporter signature motif; other site 443149008227 Walker B; other site 443149008228 D-loop; other site 443149008229 H-loop/switch region; other site 443149008230 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 443149008231 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 443149008232 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 443149008233 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 443149008234 acyltransferase PapA5; Provisional; Region: PRK09294 443149008235 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 443149008236 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 443149008237 active site 443149008238 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 443149008239 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 443149008240 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443149008241 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 443149008242 Enoylreductase; Region: PKS_ER; smart00829 443149008243 NAD(P) binding site [chemical binding]; other site 443149008244 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 443149008245 KR domain; Region: KR; pfam08659 443149008246 putative NADP binding site [chemical binding]; other site 443149008247 active site 443149008248 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 443149008249 acyl-CoA synthetase; Validated; Region: PRK05850 443149008250 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 443149008251 acyl-activating enzyme (AAE) consensus motif; other site 443149008252 active site 443149008253 MMPL family; Region: MMPL; pfam03176 443149008254 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 443149008255 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 443149008256 Integrase core domain; Region: rve; pfam00665 443149008257 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 443149008258 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443149008259 ATP binding site [chemical binding]; other site 443149008260 Walker A motif; other site 443149008261 Walker B motif; other site 443149008262 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 443149008263 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 443149008264 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 443149008265 active site 443149008266 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 443149008267 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 443149008268 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 443149008269 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443149008270 Enoylreductase; Region: PKS_ER; smart00829 443149008271 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 443149008272 NAD(P) binding site [chemical binding]; other site 443149008273 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 443149008274 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 443149008275 putative NADP binding site [chemical binding]; other site 443149008276 active site 443149008277 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 443149008278 Erythronolide synthase docking; Region: Docking; pfam08990 443149008279 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 443149008280 acyl-CoA synthetase; Validated; Region: PRK06060 443149008281 Benzoate CoA ligase (BCL) and similar adenylate forming enzymes; Region: BCL_like; cd05919 443149008282 dimer interface [polypeptide binding]; other site 443149008283 acyl-activating enzyme (AAE) consensus motif; other site 443149008284 putative active site [active] 443149008285 putative AMP binding site [chemical binding]; other site 443149008286 putative CoA binding site [chemical binding]; other site 443149008287 chemical substrate binding site [chemical binding]; other site 443149008288 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 443149008289 4-hydroxybenzoate synthetase (chorismate lyase) [Coenzyme metabolism]; Region: UbiC; COG3161 443149008290 acyl-CoA synthetase; Validated; Region: PRK05850 443149008291 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 443149008292 acyl-activating enzyme (AAE) consensus motif; other site 443149008293 active site 443149008294 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 443149008295 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 443149008296 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149008297 S-adenosylmethionine binding site [chemical binding]; other site 443149008298 Uncharacterized conserved protein [Function unknown]; Region: COG3268 443149008299 Methyltransferase domain; Region: Methyltransf_23; pfam13489 443149008300 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149008301 S-adenosylmethionine binding site [chemical binding]; other site 443149008302 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 443149008303 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 443149008304 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 443149008305 metal-binding site 443149008306 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443149008307 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 443149008308 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 443149008309 active site 443149008310 TDP-binding site; other site 443149008311 acceptor substrate-binding pocket; other site 443149008312 Cephalosporin hydroxylase [Defense mechanisms]; Region: CmcI; COG3510 443149008313 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 443149008314 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 443149008315 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 443149008316 active site 443149008317 TDP-binding site; other site 443149008318 acceptor substrate-binding pocket; other site 443149008319 Predicted permease; Region: DUF318; pfam03773 443149008320 formyltetrahydrofolate deformylase; Region: PurU; TIGR00655 443149008321 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 443149008322 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 443149008323 putative active site [active] 443149008324 putative substrate binding site [chemical binding]; other site 443149008325 putative cosubstrate binding site; other site 443149008326 catalytic site [active] 443149008327 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 443149008328 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 443149008329 active site 443149008330 (T/H)XGH motif; other site 443149008331 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 443149008332 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149008333 S-adenosylmethionine binding site [chemical binding]; other site 443149008334 pyruvate carboxylase; Reviewed; Region: PRK12999 443149008335 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 443149008336 ATP-grasp domain; Region: ATP-grasp_4; cl17255 443149008337 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 443149008338 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 443149008339 active site 443149008340 catalytic residues [active] 443149008341 metal binding site [ion binding]; metal-binding site 443149008342 homodimer binding site [polypeptide binding]; other site 443149008343 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 443149008344 carboxyltransferase (CT) interaction site; other site 443149008345 biotinylation site [posttranslational modification]; other site 443149008346 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 443149008347 putative active site [active] 443149008348 redox center [active] 443149008349 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 443149008350 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 443149008351 catalytic residues [active] 443149008352 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 443149008353 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 443149008354 substrate binding pocket [chemical binding]; other site 443149008355 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 443149008356 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 443149008357 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 443149008358 active site 443149008359 catalytic tetrad [active] 443149008360 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 443149008361 RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200 443149008362 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 443149008363 generic binding surface II; other site 443149008364 ssDNA binding site; other site 443149008365 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443149008366 ATP binding site [chemical binding]; other site 443149008367 putative Mg++ binding site [ion binding]; other site 443149008368 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443149008369 nucleotide binding region [chemical binding]; other site 443149008370 ATP-binding site [chemical binding]; other site 443149008371 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 443149008372 DAK2 domain; Region: Dak2; cl03685 443149008373 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 443149008374 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 443149008375 ligand binding site [chemical binding]; other site 443149008376 active site 443149008377 UGI interface [polypeptide binding]; other site 443149008378 catalytic site [active] 443149008379 thiamine monophosphate kinase; Provisional; Region: PRK05731 443149008380 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 443149008381 ATP binding site [chemical binding]; other site 443149008382 dimerization interface [polypeptide binding]; other site 443149008383 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 443149008384 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 443149008385 Probable transposase; Region: OrfB_IS605; pfam01385 443149008386 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 443149008387 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 443149008388 catalytic residues [active] 443149008389 catalytic nucleophile [active] 443149008390 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 443149008391 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 443149008392 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 443149008393 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 443149008394 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 443149008395 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 443149008396 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 443149008397 Predicted nucleotidyltransferase, CobY/MobA/RfbA family [General function prediction only]; Region: COG1920 443149008398 polyphosphate kinase; Provisional; Region: PRK05443 443149008399 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 443149008400 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 443149008401 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 443149008402 putative domain interface [polypeptide binding]; other site 443149008403 putative active site [active] 443149008404 catalytic site [active] 443149008405 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 443149008406 putative domain interface [polypeptide binding]; other site 443149008407 putative active site [active] 443149008408 catalytic site [active] 443149008409 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 443149008410 active site 443149008411 Ap6A binding site [chemical binding]; other site 443149008412 nudix motif; other site 443149008413 metal binding site [ion binding]; metal-binding site 443149008414 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 443149008415 catalytic core [active] 443149008416 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 443149008417 IHF - DNA interface [nucleotide binding]; other site 443149008418 IHF dimer interface [polypeptide binding]; other site 443149008419 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 443149008420 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 443149008421 substrate binding site [chemical binding]; other site 443149008422 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 443149008423 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 443149008424 substrate binding site [chemical binding]; other site 443149008425 ligand binding site [chemical binding]; other site 443149008426 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 443149008427 Transcriptional regulator [Transcription]; Region: IclR; COG1414 443149008428 Bacterial transcriptional regulator; Region: IclR; pfam01614 443149008429 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149008430 S-adenosylmethionine binding site [chemical binding]; other site 443149008431 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 443149008432 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 443149008433 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 443149008434 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 443149008435 active site 443149008436 HIGH motif; other site 443149008437 nucleotide binding site [chemical binding]; other site 443149008438 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 443149008439 active site 443149008440 KMSKS motif; other site 443149008441 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 443149008442 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 443149008443 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 443149008444 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443149008445 Major Facilitator Superfamily; Region: MFS_1; pfam07690 443149008446 putative substrate translocation pore; other site 443149008447 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 443149008448 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 443149008449 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 443149008450 ligand binding site [chemical binding]; other site 443149008451 NAD binding site [chemical binding]; other site 443149008452 dimerization interface [polypeptide binding]; other site 443149008453 catalytic site [active] 443149008454 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 443149008455 putative L-serine binding site [chemical binding]; other site 443149008456 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 443149008457 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 443149008458 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 443149008459 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 443149008460 phosphorylation site [posttranslational modification] 443149008461 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 443149008462 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 443149008463 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 443149008464 ketol-acid reductoisomerase; Provisional; Region: PRK05479 443149008465 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 443149008466 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 443149008467 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 443149008468 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 443149008469 putative valine binding site [chemical binding]; other site 443149008470 dimer interface [polypeptide binding]; other site 443149008471 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 443149008472 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 443149008473 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 443149008474 PYR/PP interface [polypeptide binding]; other site 443149008475 dimer interface [polypeptide binding]; other site 443149008476 TPP binding site [chemical binding]; other site 443149008477 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 443149008478 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 443149008479 TPP-binding site [chemical binding]; other site 443149008480 dimer interface [polypeptide binding]; other site 443149008481 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 443149008482 Predicted membrane protein [Function unknown]; Region: COG2259 443149008483 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 443149008484 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 443149008485 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 443149008486 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 443149008487 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 443149008488 GatB domain; Region: GatB_Yqey; smart00845 443149008489 6-phosphofructokinase; Provisional; Region: PRK03202 443149008490 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 443149008491 active site 443149008492 ADP/pyrophosphate binding site [chemical binding]; other site 443149008493 dimerization interface [polypeptide binding]; other site 443149008494 allosteric effector site; other site 443149008495 fructose-1,6-bisphosphate binding site; other site 443149008496 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 443149008497 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 443149008498 aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, C subunit; Region: gatC; TIGR00135 443149008499 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 443149008500 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 443149008501 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 443149008502 nucleotide binding pocket [chemical binding]; other site 443149008503 K-X-D-G motif; other site 443149008504 catalytic site [active] 443149008505 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 443149008506 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 443149008507 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 443149008508 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 443149008509 Dimer interface [polypeptide binding]; other site 443149008510 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 443149008511 PknH-like extracellular domain; Region: PknH_C; pfam14032 443149008512 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 443149008513 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149008514 PPE family; Region: PPE; pfam00823 443149008515 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 443149008516 Transposase; Region: HTH_Tnp_1; cl17663 443149008517 putative transposase OrfB; Reviewed; Region: PHA02517 443149008518 HTH-like domain; Region: HTH_21; pfam13276 443149008519 Integrase core domain; Region: rve; pfam00665 443149008520 Integrase core domain; Region: rve_3; pfam13683 443149008521 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149008522 PPE family; Region: PPE; pfam00823 443149008523 Transposase, Mutator family; Region: Transposase_mut; pfam00872 443149008524 MULE transposase domain; Region: MULE; pfam10551 443149008525 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 443149008526 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 443149008527 Ligand Binding Site [chemical binding]; other site 443149008528 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 443149008529 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 443149008530 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443149008531 catalytic residue [active] 443149008532 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 443149008533 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 443149008534 putative acyl-acceptor binding pocket; other site 443149008535 Putative hemolysin [General function prediction only]; Region: COG3176 443149008536 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 443149008537 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 443149008538 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 443149008539 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 443149008540 Ligand binding site [chemical binding]; other site 443149008541 Electron transfer flavoprotein domain; Region: ETF; pfam01012 443149008542 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149008543 S-adenosylmethionine binding site [chemical binding]; other site 443149008544 Uncharacterized conserved protein [Function unknown]; Region: COG1543 443149008545 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 443149008546 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 443149008547 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443149008548 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 443149008549 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 443149008550 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 443149008551 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 443149008552 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 443149008553 trimer interface [polypeptide binding]; other site 443149008554 active site 443149008555 substrate binding site [chemical binding]; other site 443149008556 CoA binding site [chemical binding]; other site 443149008557 FOG: WD40-like repeat [Function unknown]; Region: COG1520 443149008558 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 443149008559 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149008560 S-adenosylmethionine binding site [chemical binding]; other site 443149008561 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443149008562 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 443149008563 substrate binding site [chemical binding]; other site 443149008564 oxyanion hole (OAH) forming residues; other site 443149008565 trimer interface [polypeptide binding]; other site 443149008566 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 443149008567 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443149008568 Walker A/P-loop; other site 443149008569 ATP binding site [chemical binding]; other site 443149008570 Q-loop/lid; other site 443149008571 ABC transporter signature motif; other site 443149008572 Walker B; other site 443149008573 D-loop; other site 443149008574 H-loop/switch region; other site 443149008575 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 443149008576 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 443149008577 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 443149008578 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443149008579 motif II; other site 443149008580 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 443149008581 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 443149008582 D-pathway; other site 443149008583 Putative ubiquinol binding site [chemical binding]; other site 443149008584 Low-spin heme (heme b) binding site [chemical binding]; other site 443149008585 Putative water exit pathway; other site 443149008586 Binuclear center (heme o3/CuB) [ion binding]; other site 443149008587 K-pathway; other site 443149008588 Putative proton exit pathway; other site 443149008589 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 443149008590 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 443149008591 siderophore binding site; other site 443149008592 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 443149008593 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 443149008594 putative NAD(P) binding site [chemical binding]; other site 443149008595 putative substrate binding site [chemical binding]; other site 443149008596 catalytic Zn binding site [ion binding]; other site 443149008597 structural Zn binding site [ion binding]; other site 443149008598 dimer interface [polypeptide binding]; other site 443149008599 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 443149008600 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 443149008601 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 443149008602 dimer interface [polypeptide binding]; other site 443149008603 putative radical transfer pathway; other site 443149008604 diiron center [ion binding]; other site 443149008605 tyrosyl radical; other site 443149008606 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 443149008607 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 443149008608 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149008609 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149008610 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 443149008611 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 443149008612 Class I ribonucleotide reductase; Region: RNR_I; cd01679 443149008613 active site 443149008614 dimer interface [polypeptide binding]; other site 443149008615 catalytic residues [active] 443149008616 effector binding site; other site 443149008617 R2 peptide binding site; other site 443149008618 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 443149008619 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 443149008620 catalytic residues [active] 443149008621 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 443149008622 Predicted flavoprotein [General function prediction only]; Region: COG0431 443149008623 DNA polymerase IV; Validated; Region: PRK03352 443149008624 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 443149008625 DNA binding site [nucleotide binding] 443149008626 short chain dehydrogenase; Provisional; Region: PRK07832 443149008627 classical (c) SDRs; Region: SDR_c; cd05233 443149008628 NAD(P) binding site [chemical binding]; other site 443149008629 active site 443149008630 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149008631 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149008632 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443149008633 Cytochrome P450; Region: p450; cl12078 443149008634 Transcriptional regulators [Transcription]; Region: FadR; COG2186 443149008635 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443149008636 DNA-binding site [nucleotide binding]; DNA binding site 443149008637 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 443149008638 Transcriptional regulators [Transcription]; Region: FadR; COG2186 443149008639 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443149008640 DNA-binding site [nucleotide binding]; DNA binding site 443149008641 FCD domain; Region: FCD; pfam07729 443149008642 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149008643 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 443149008644 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443149008645 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149008646 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149008647 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443149008648 active site 443149008649 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 443149008650 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 443149008651 active site 443149008652 DNA binding site [nucleotide binding] 443149008653 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 443149008654 DNA binding site [nucleotide binding] 443149008655 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 443149008656 Carbon starvation protein CstA; Region: CstA; pfam02554 443149008657 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 443149008658 Predicted membrane protein [Function unknown]; Region: COG2259 443149008659 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 443149008660 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 443149008661 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149008662 Protein of unknown function (DUF732); Region: DUF732; pfam05305 443149008663 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 443149008664 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 443149008665 active site 443149008666 substrate binding site [chemical binding]; other site 443149008667 metal binding site [ion binding]; metal-binding site 443149008668 camphor resistance protein CrcB; Provisional; Region: PRK14216 443149008669 camphor resistance protein CrcB; Provisional; Region: PRK14228 443149008670 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 443149008671 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 443149008672 Uncharacterized ACR, COG1993; Region: DUF190; pfam02641 443149008673 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 443149008674 Uncharacterized conserved protein [Function unknown]; Region: COG3189 443149008675 Domain of unknown function (DUF222); Region: DUF222; pfam02720 443149008676 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 443149008677 active site 443149008678 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 443149008679 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 443149008680 putative hydrophobic ligand binding site [chemical binding]; other site 443149008681 protein interface [polypeptide binding]; other site 443149008682 gate; other site 443149008683 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 443149008684 Sulfatase; Region: Sulfatase; pfam00884 443149008685 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 443149008686 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 443149008687 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 443149008688 Catalytic domain of Protein Kinases; Region: PKc; cd00180 443149008689 active site 443149008690 ATP binding site [chemical binding]; other site 443149008691 substrate binding site [chemical binding]; other site 443149008692 activation loop (A-loop); other site 443149008693 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 443149008694 AAA ATPase domain; Region: AAA_16; pfam13191 443149008695 Nucleotidyl transferase of unknown function (DUF2204); Region: DUF2204; pfam09970 443149008696 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 443149008697 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 443149008698 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 443149008699 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 443149008700 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 443149008701 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 443149008702 short chain dehydrogenase; Provisional; Region: PRK07832 443149008703 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443149008704 NAD(P) binding site [chemical binding]; other site 443149008705 active site 443149008706 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 443149008707 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 443149008708 NAD binding site [chemical binding]; other site 443149008709 catalytic Zn binding site [ion binding]; other site 443149008710 substrate binding site [chemical binding]; other site 443149008711 structural Zn binding site [ion binding]; other site 443149008712 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443149008713 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443149008714 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443149008715 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443149008716 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 443149008717 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 443149008718 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443149008719 acyl-activating enzyme (AAE) consensus motif; other site 443149008720 AMP binding site [chemical binding]; other site 443149008721 active site 443149008722 CoA binding site [chemical binding]; other site 443149008723 SPFH domain / Band 7 family; Region: Band_7; pfam01145 443149008724 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 443149008725 Patatin-like phospholipase; Region: Patatin; pfam01734 443149008726 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 443149008727 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 443149008728 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 443149008729 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149008730 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443149008731 active site 443149008732 Predicted transcriptional regulators [Transcription]; Region: COG1733 443149008733 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443149008734 dimerization interface [polypeptide binding]; other site 443149008735 putative DNA binding site [nucleotide binding]; other site 443149008736 putative Zn2+ binding site [ion binding]; other site 443149008737 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 443149008738 PE family; Region: PE; pfam00934 443149008739 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 443149008740 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 443149008741 PemK-like protein; Region: PemK; pfam02452 443149008742 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 443149008743 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 443149008744 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 443149008745 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 443149008746 SmpB-tmRNA interface; other site 443149008747 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 443149008748 FtsX-like permease family; Region: FtsX; pfam02687 443149008749 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 443149008750 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443149008751 Walker A/P-loop; other site 443149008752 ATP binding site [chemical binding]; other site 443149008753 Q-loop/lid; other site 443149008754 ABC transporter signature motif; other site 443149008755 Walker B; other site 443149008756 D-loop; other site 443149008757 H-loop/switch region; other site 443149008758 Mechanosensitive ion channel; Region: MS_channel; pfam00924 443149008759 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 443149008760 peptide chain release factor 2; Validated; Region: prfB; PRK00578 443149008761 This domain is found in peptide chain release factors; Region: PCRF; smart00937 443149008762 RF-1 domain; Region: RF-1; pfam00472 443149008763 ferredoxin-NADP+ reductase; Region: PLN02852 443149008764 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 443149008765 FAD binding domain; Region: FAD_binding_4; pfam01565 443149008766 Molybdenum cofactor biosynthesis enzyme [Coenzyme metabolism]; Region: MoaA; COG2896 443149008767 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443149008768 FeS/SAM binding site; other site 443149008769 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 443149008770 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 443149008771 aromatic arch; other site 443149008772 DCoH dimer interaction site [polypeptide binding]; other site 443149008773 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 443149008774 DCoH tetramer interaction site [polypeptide binding]; other site 443149008775 substrate binding site [chemical binding]; other site 443149008776 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 443149008777 trimer interface [polypeptide binding]; other site 443149008778 dimer interface [polypeptide binding]; other site 443149008779 putative active site [active] 443149008780 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 443149008781 MoaE interaction surface [polypeptide binding]; other site 443149008782 MoeB interaction surface [polypeptide binding]; other site 443149008783 thiocarboxylated glycine; other site 443149008784 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 443149008785 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 443149008786 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 443149008787 nucleoside/Zn binding site; other site 443149008788 dimer interface [polypeptide binding]; other site 443149008789 catalytic motif [active] 443149008790 Transposase, Mutator family; Region: Transposase_mut; pfam00872 443149008791 MULE transposase domain; Region: MULE; pfam10551 443149008792 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 443149008793 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 443149008794 ATP binding site [chemical binding]; other site 443149008795 substrate interface [chemical binding]; other site 443149008796 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 443149008797 active site residue [active] 443149008798 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 443149008799 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 443149008800 active site residue [active] 443149008801 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 443149008802 active site residue [active] 443149008803 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 443149008804 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 443149008805 MoaE homodimer interface [polypeptide binding]; other site 443149008806 MoaD interaction [polypeptide binding]; other site 443149008807 active site residues [active] 443149008808 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149008809 S-adenosylmethionine binding site [chemical binding]; other site 443149008810 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443149008811 Cytochrome P450; Region: p450; cl12078 443149008812 Transposase IS200 like; Region: Y1_Tnp; cl00848 443149008813 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 443149008814 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 443149008815 DNA binding site [nucleotide binding] 443149008816 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149008817 PPE family; Region: PPE; pfam00823 443149008818 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 443149008819 putative transposase OrfB; Reviewed; Region: PHA02517 443149008820 HTH-like domain; Region: HTH_21; pfam13276 443149008821 Integrase core domain; Region: rve; pfam00665 443149008822 Integrase core domain; Region: rve_3; pfam13683 443149008823 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 443149008824 Transposase; Region: HTH_Tnp_1; cl17663 443149008825 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 443149008826 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443149008827 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443149008828 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 443149008829 dimer interface [polypeptide binding]; other site 443149008830 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 443149008831 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 443149008832 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 443149008833 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 443149008834 Histidine kinase; Region: HisKA_3; pfam07730 443149008835 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443149008836 ATP binding site [chemical binding]; other site 443149008837 Mg2+ binding site [ion binding]; other site 443149008838 G-X-G motif; other site 443149008839 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443149008840 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443149008841 active site 443149008842 phosphorylation site [posttranslational modification] 443149008843 intermolecular recognition site; other site 443149008844 dimerization interface [polypeptide binding]; other site 443149008845 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443149008846 DNA binding residues [nucleotide binding] 443149008847 dimerization interface [polypeptide binding]; other site 443149008848 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 443149008849 Ligand Binding Site [chemical binding]; other site 443149008850 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149008851 PPE family; Region: PPE; pfam00823 443149008852 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149008853 PPE family; Region: PPE; pfam00823 443149008854 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 443149008855 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 443149008856 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 443149008857 active site 443149008858 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 443149008859 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443149008860 FeS/SAM binding site; other site 443149008861 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149008862 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443149008863 active site 443149008864 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149008865 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443149008866 active site 443149008867 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 443149008868 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 443149008869 NAD(P) binding site [chemical binding]; other site 443149008870 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443149008871 active site 443149008872 phosphorylation site [posttranslational modification] 443149008873 intermolecular recognition site; other site 443149008874 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149008875 PPE family; Region: PPE; pfam00823 443149008876 NADH dehydrogenase subunit A; Validated; Region: PRK07928 443149008877 NADH dehydrogenase subunit B; Validated; Region: PRK06411 443149008878 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 443149008879 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 443149008880 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 443149008881 NADH dehydrogenase subunit D; Validated; Region: PRK06075 443149008882 NADH dehydrogenase subunit E; Validated; Region: PRK07539 443149008883 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 443149008884 putative dimer interface [polypeptide binding]; other site 443149008885 [2Fe-2S] cluster binding site [ion binding]; other site 443149008886 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 443149008887 SLBB domain; Region: SLBB; pfam10531 443149008888 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 443149008889 NADH dehydrogenase subunit G; Validated; Region: PRK07860 443149008890 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443149008891 catalytic loop [active] 443149008892 iron binding site [ion binding]; other site 443149008893 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 443149008894 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 443149008895 [4Fe-4S] binding site [ion binding]; other site 443149008896 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 443149008897 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 443149008898 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 443149008899 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 443149008900 4Fe-4S binding domain; Region: Fer4; pfam00037 443149008901 4Fe-4S binding domain; Region: Fer4; pfam00037 443149008902 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 443149008903 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 443149008904 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 443149008905 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 443149008906 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 443149008907 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 443149008908 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 443149008909 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 443149008910 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 443149008911 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149008912 PPE family; Region: PPE; pfam00823 443149008913 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149008914 PPE family; Region: PPE; pfam00823 443149008915 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 443149008916 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149008917 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 443149008918 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 443149008919 [2Fe-2S] cluster binding site [ion binding]; other site 443149008920 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_1; cd08885 443149008921 putative alpha subunit interface [polypeptide binding]; other site 443149008922 putative active site [active] 443149008923 putative substrate binding site [chemical binding]; other site 443149008924 Fe binding site [ion binding]; other site 443149008925 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 443149008926 Protein of unknown function DUF58; Region: DUF58; pfam01882 443149008927 MoxR-like ATPases [General function prediction only]; Region: COG0714 443149008928 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443149008929 Walker A motif; other site 443149008930 ATP binding site [chemical binding]; other site 443149008931 Walker B motif; other site 443149008932 arginine finger; other site 443149008933 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 443149008934 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149008935 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149008936 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 443149008937 putative active site [active] 443149008938 putative substrate binding site [chemical binding]; other site 443149008939 ATP binding site [chemical binding]; other site 443149008940 Phosphotransferase enzyme family; Region: APH; pfam01636 443149008941 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 443149008942 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 443149008943 hydroxyglutarate oxidase; Provisional; Region: PRK11728 443149008944 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443149008945 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 443149008946 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149008947 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149008948 short chain dehydrogenase; Validated; Region: PRK08264 443149008949 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443149008950 NAD(P) binding site [chemical binding]; other site 443149008951 active site 443149008952 amidase; Provisional; Region: PRK06170 443149008953 Amidase; Region: Amidase; pfam01425 443149008954 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443149008955 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443149008956 TAP-like protein; Region: Abhydrolase_4; pfam08386 443149008957 Domain of unknown function (DUF385); Region: DUF385; pfam04075 443149008958 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 443149008959 AAA domain; Region: AAA_14; pfam13173 443149008960 putative transposase OrfB; Reviewed; Region: PHA02517 443149008961 HTH-like domain; Region: HTH_21; pfam13276 443149008962 Integrase core domain; Region: rve; pfam00665 443149008963 Integrase core domain; Region: rve_3; pfam13683 443149008964 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 443149008965 Transposase; Region: HTH_Tnp_1; cl17663 443149008966 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 443149008967 putative active site [active] 443149008968 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 443149008969 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4683 443149008970 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443149008971 non-specific DNA binding site [nucleotide binding]; other site 443149008972 salt bridge; other site 443149008973 sequence-specific DNA binding site [nucleotide binding]; other site 443149008974 RES domain; Region: RES; pfam08808 443149008975 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 443149008976 Helix-turn-helix domain; Region: HTH_38; pfam13936 443149008977 Integrase core domain; Region: rve; pfam00665 443149008978 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 443149008979 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 443149008980 hypothetical protein; Validated; Region: PRK00068 443149008981 Uncharacterized conserved protein [Function unknown]; Region: COG1615 443149008982 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 443149008983 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 443149008984 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 443149008985 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 443149008986 Uncharacterized conserved protein [Function unknown]; Region: COG5282 443149008987 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 443149008988 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 443149008989 ABC1 family; Region: ABC1; pfam03109 443149008990 Phosphotransferase enzyme family; Region: APH; pfam01636 443149008991 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 443149008992 active site 443149008993 ATP binding site [chemical binding]; other site 443149008994 Transcription factor WhiB; Region: Whib; pfam02467 443149008995 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 443149008996 Part of AAA domain; Region: AAA_19; pfam13245 443149008997 Family description; Region: UvrD_C_2; pfam13538 443149008998 HRDC domain; Region: HRDC; pfam00570 443149008999 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 443149009000 catalytic residues [active] 443149009001 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 443149009002 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 443149009003 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 443149009004 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 443149009005 putative NADH binding site [chemical binding]; other site 443149009006 putative active site [active] 443149009007 nudix motif; other site 443149009008 putative metal binding site [ion binding]; other site 443149009009 Ion channel; Region: Ion_trans_2; pfam07885 443149009010 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 443149009011 TrkA-N domain; Region: TrkA_N; pfam02254 443149009012 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 443149009013 Part of AAA domain; Region: AAA_19; pfam13245 443149009014 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 443149009015 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 443149009016 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 443149009017 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 443149009018 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 443149009019 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 443149009020 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 443149009021 active site 443149009022 DNA binding site [nucleotide binding] 443149009023 TIGR02569 family protein; Region: TIGR02569_actnb 443149009024 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 443149009025 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 443149009026 ATP binding site [chemical binding]; other site 443149009027 substrate interface [chemical binding]; other site 443149009028 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 443149009029 active site residue [active] 443149009030 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 443149009031 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149009032 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149009033 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 443149009034 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like; Region: MiaE_2; pfam13794 443149009035 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 443149009036 DEAD-like helicases superfamily; Region: DEXDc; smart00487 443149009037 ATP binding site [chemical binding]; other site 443149009038 Mg++ binding site [ion binding]; other site 443149009039 motif III; other site 443149009040 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443149009041 nucleotide binding region [chemical binding]; other site 443149009042 ATP-binding site [chemical binding]; other site 443149009043 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 443149009044 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 443149009045 P-loop; other site 443149009046 Magnesium ion binding site [ion binding]; other site 443149009047 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 443149009048 Magnesium ion binding site [ion binding]; other site 443149009049 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 443149009050 catalytic core [active] 443149009051 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 443149009052 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 443149009053 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 443149009054 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 443149009055 Transcription factor WhiB; Region: Whib; pfam02467 443149009056 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 443149009057 PAS domain S-box; Region: sensory_box; TIGR00229 443149009058 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 443149009059 Histidine kinase; Region: HisKA_2; pfam07568 443149009060 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443149009061 ATP binding site [chemical binding]; other site 443149009062 Mg2+ binding site [ion binding]; other site 443149009063 G-X-G motif; other site 443149009064 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 443149009065 carboxyltransferase (CT) interaction site; other site 443149009066 biotinylation site [posttranslational modification]; other site 443149009067 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 443149009068 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 443149009069 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443149009070 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443149009071 DNA binding residues [nucleotide binding] 443149009072 short chain dehydrogenase; Provisional; Region: PRK08278 443149009073 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 443149009074 NAD(P) binding site [chemical binding]; other site 443149009075 homodimer interface [polypeptide binding]; other site 443149009076 active site 443149009077 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 443149009078 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 443149009079 putative deacylase active site [active] 443149009080 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 443149009081 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443149009082 Coenzyme A binding pocket [chemical binding]; other site 443149009083 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 443149009084 Phosphotransferase enzyme family; Region: APH; pfam01636 443149009085 putative active site [active] 443149009086 putative substrate binding site [chemical binding]; other site 443149009087 ATP binding site [chemical binding]; other site 443149009088 Uncharacterized conserved protein [Function unknown]; Region: COG2135 443149009089 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 443149009090 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 443149009091 hinge; other site 443149009092 active site 443149009093 Predicted GTPases [General function prediction only]; Region: COG1162 443149009094 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 443149009095 GTPase/Zn-binding domain interface [polypeptide binding]; other site 443149009096 GTP/Mg2+ binding site [chemical binding]; other site 443149009097 G4 box; other site 443149009098 G5 box; other site 443149009099 G1 box; other site 443149009100 Switch I region; other site 443149009101 G2 box; other site 443149009102 G3 box; other site 443149009103 Switch II region; other site 443149009104 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 443149009105 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 443149009106 putative di-iron ligands [ion binding]; other site 443149009107 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 443149009108 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 443149009109 FAD binding pocket [chemical binding]; other site 443149009110 FAD binding motif [chemical binding]; other site 443149009111 phosphate binding motif [ion binding]; other site 443149009112 beta-alpha-beta structure motif; other site 443149009113 NAD binding pocket [chemical binding]; other site 443149009114 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443149009115 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 443149009116 catalytic loop [active] 443149009117 iron binding site [ion binding]; other site 443149009118 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 443149009119 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443149009120 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443149009121 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 443149009122 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 443149009123 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 443149009124 TrkA-C domain; Region: TrkA_C; pfam02080 443149009125 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 443149009126 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443149009127 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 443149009128 putative substrate translocation pore; other site 443149009129 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 443149009130 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 443149009131 ligand binding site [chemical binding]; other site 443149009132 flexible hinge region; other site 443149009133 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 443149009134 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 443149009135 nucleophile elbow; other site 443149009136 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 443149009137 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 443149009138 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 443149009139 30S subunit binding site; other site 443149009140 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 443149009141 active site 443149009142 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 443149009143 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 443149009144 lipoprotein LpqB; Provisional; Region: PRK13616 443149009145 Sporulation and spore germination; Region: Germane; pfam10646 443149009146 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 443149009147 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443149009148 dimerization interface [polypeptide binding]; other site 443149009149 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443149009150 dimer interface [polypeptide binding]; other site 443149009151 phosphorylation site [posttranslational modification] 443149009152 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443149009153 ATP binding site [chemical binding]; other site 443149009154 Mg2+ binding site [ion binding]; other site 443149009155 G-X-G motif; other site 443149009156 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 443149009157 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443149009158 active site 443149009159 phosphorylation site [posttranslational modification] 443149009160 intermolecular recognition site; other site 443149009161 dimerization interface [polypeptide binding]; other site 443149009162 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443149009163 DNA binding site [nucleotide binding] 443149009164 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 443149009165 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 443149009166 TMP-binding site; other site 443149009167 ATP-binding site [chemical binding]; other site 443149009168 Adenosylhomocysteinase; Provisional; Region: PTZ00075 443149009169 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 443149009170 homotetramer interface [polypeptide binding]; other site 443149009171 ligand binding site [chemical binding]; other site 443149009172 catalytic site [active] 443149009173 NAD binding site [chemical binding]; other site 443149009174 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149009175 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 443149009176 Rubredoxin [Energy production and conversion]; Region: COG1773 443149009177 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 443149009178 iron binding site [ion binding]; other site 443149009179 Rubredoxin [Energy production and conversion]; Region: COG1773 443149009180 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 443149009181 iron binding site [ion binding]; other site 443149009182 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 443149009183 Fatty acid desaturase; Region: FA_desaturase; pfam00487 443149009184 Di-iron ligands [ion binding]; other site 443149009185 amino acid transporter; Region: 2A0306; TIGR00909 443149009186 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 443149009187 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 443149009188 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 443149009189 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 443149009190 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 443149009191 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 443149009192 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 443149009193 active site 443149009194 substrate binding site [chemical binding]; other site 443149009195 metal binding site [ion binding]; metal-binding site 443149009196 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 443149009197 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 443149009198 Transcription factor WhiB; Region: Whib; pfam02467 443149009199 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 443149009200 LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186 443149009201 phosphate binding site [ion binding]; other site 443149009202 dimer interface [polypeptide binding]; other site 443149009203 substrate binding site [chemical binding]; other site 443149009204 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 443149009205 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 443149009206 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 443149009207 putative FMN binding site [chemical binding]; other site 443149009208 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 443149009209 Methyltransferase domain; Region: Methyltransf_26; pfam13659 443149009210 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 443149009211 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 443149009212 active site 443149009213 Substrate binding site; other site 443149009214 Mg++ binding site; other site 443149009215 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 443149009216 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 443149009217 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 443149009218 Probable Catalytic site; other site 443149009219 metal-binding site 443149009220 dTDP-4-dehydrorhamnose reductase; Region: rmlD; TIGR01214 443149009221 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 443149009222 NADP binding site [chemical binding]; other site 443149009223 active site 443149009224 putative substrate binding site [chemical binding]; other site 443149009225 Transcriptional regulator [Transcription]; Region: LytR; COG1316 443149009226 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 443149009227 TIGR03089 family protein; Region: TIGR03089 443149009228 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 443149009229 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 443149009230 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 443149009231 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 443149009232 active site 443149009233 motif I; other site 443149009234 motif II; other site 443149009235 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 443149009236 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 443149009237 CoA-transferase family III; Region: CoA_transf_3; pfam02515 443149009238 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 443149009239 Sulfate transporter family; Region: Sulfate_transp; pfam00916 443149009240 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: CynT; COG0288 443149009241 active site clefts [active] 443149009242 zinc binding site [ion binding]; other site 443149009243 dimer interface [polypeptide binding]; other site 443149009244 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149009245 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 443149009246 FAD binding site [chemical binding]; other site 443149009247 homotetramer interface [polypeptide binding]; other site 443149009248 substrate binding pocket [chemical binding]; other site 443149009249 catalytic base [active] 443149009250 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 443149009251 Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) [Nucleotide transport and metabolism]; Region: PurK; COG0026 443149009252 ATP-grasp domain; Region: ATP-grasp; pfam02222 443149009253 Predicted membrane protein [Function unknown]; Region: COG2246 443149009254 GtrA-like protein; Region: GtrA; pfam04138 443149009255 Bacterial PH domain; Region: DUF304; pfam03703 443149009256 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 443149009257 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 443149009258 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 443149009259 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 443149009260 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 443149009261 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 443149009262 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 443149009263 Maf-like protein; Region: Maf; pfam02545 443149009264 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 443149009265 active site 443149009266 dimer interface [polypeptide binding]; other site 443149009267 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 443149009268 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 443149009269 active site residue [active] 443149009270 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 443149009271 active site residue [active] 443149009272 Fe-S metabolism associated domain; Region: SufE; pfam02657 443149009273 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 443149009274 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 443149009275 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 443149009276 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 443149009277 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 443149009278 carboxyltransferase (CT) interaction site; other site 443149009279 biotinylation site [posttranslational modification]; other site 443149009280 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 443149009281 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443149009282 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 443149009283 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 443149009284 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 443149009285 L-lysine aminotransferase; Provisional; Region: PRK08297 443149009286 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 443149009287 inhibitor-cofactor binding pocket; inhibition site 443149009288 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443149009289 catalytic residue [active] 443149009290 putative DNA binding site [nucleotide binding]; other site 443149009291 dimerization interface [polypeptide binding]; other site 443149009292 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 443149009293 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 443149009294 putative Zn2+ binding site [ion binding]; other site 443149009295 AsnC family; Region: AsnC_trans_reg; pfam01037 443149009296 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 443149009297 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 443149009298 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 443149009299 tetrameric interface [polypeptide binding]; other site 443149009300 NAD binding site [chemical binding]; other site 443149009301 catalytic residues [active] 443149009302 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 443149009303 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149009304 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149009305 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443149009306 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 443149009307 ATP binding site [chemical binding]; other site 443149009308 putative Mg++ binding site [ion binding]; other site 443149009309 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443149009310 nucleotide binding region [chemical binding]; other site 443149009311 ATP-binding site [chemical binding]; other site 443149009312 DEAD/H associated; Region: DEAD_assoc; pfam08494 443149009313 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 443149009314 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 443149009315 putative DNA binding site [nucleotide binding]; other site 443149009316 catalytic residue [active] 443149009317 putative H2TH interface [polypeptide binding]; other site 443149009318 putative catalytic residues [active] 443149009319 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 443149009320 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 443149009321 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 443149009322 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 443149009323 Sulfatase; Region: Sulfatase; pfam00884 443149009324 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 443149009325 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 443149009326 probable active site [active] 443149009327 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 443149009328 PhoU domain; Region: PhoU; pfam01895 443149009329 PhoU domain; Region: PhoU; pfam01895 443149009330 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 443149009331 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 443149009332 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443149009333 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 443149009334 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 443149009335 putative active site pocket [active] 443149009336 dimerization interface [polypeptide binding]; other site 443149009337 putative catalytic residue [active] 443149009338 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 443149009339 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 443149009340 metal binding site [ion binding]; metal-binding site 443149009341 putative dimer interface [polypeptide binding]; other site 443149009342 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 443149009343 amidohydrolase; Region: amidohydrolases; TIGR01891 443149009344 metal binding site [ion binding]; metal-binding site 443149009345 purine nucleoside phosphorylase; Provisional; Region: PRK08202 443149009346 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 443149009347 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 443149009348 active site 443149009349 substrate binding site [chemical binding]; other site 443149009350 metal binding site [ion binding]; metal-binding site 443149009351 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 443149009352 active site 443149009353 Phosphoesterase family; Region: Phosphoesterase; pfam04185 443149009354 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443149009355 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 443149009356 adenosine deaminase; Provisional; Region: PRK09358 443149009357 active site 443149009358 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 443149009359 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 443149009360 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 443149009361 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 443149009362 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 443149009363 active site 443149009364 catalytic motif [active] 443149009365 Zn binding site [ion binding]; other site 443149009366 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 443149009367 putative Iron-sulfur protein interface [polypeptide binding]; other site 443149009368 putative proximal heme binding site [chemical binding]; other site 443149009369 putative SdhD-like interface [polypeptide binding]; other site 443149009370 putative distal heme binding site [chemical binding]; other site 443149009371 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 443149009372 putative Iron-sulfur protein interface [polypeptide binding]; other site 443149009373 putative proximal heme binding site [chemical binding]; other site 443149009374 putative SdhC-like subunit interface [polypeptide binding]; other site 443149009375 putative distal heme binding site [chemical binding]; other site 443149009376 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 443149009377 L-aspartate oxidase; Provisional; Region: PRK06175 443149009378 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 443149009379 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 443149009380 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 443149009381 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 443149009382 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 443149009383 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149009384 S-adenosylmethionine binding site [chemical binding]; other site 443149009385 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 443149009386 MoaE interaction surface [polypeptide binding]; other site 443149009387 MoeB interaction surface [polypeptide binding]; other site 443149009388 thiocarboxylated glycine; other site 443149009389 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 443149009390 MoaE homodimer interface [polypeptide binding]; other site 443149009391 MoaD interaction [polypeptide binding]; other site 443149009392 active site residues [active] 443149009393 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 443149009394 trimer interface [polypeptide binding]; other site 443149009395 dimer interface [polypeptide binding]; other site 443149009396 putative active site [active] 443149009397 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942 443149009398 DCoH dimer interaction site [polypeptide binding]; other site 443149009399 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 443149009400 DCoH tetramer interaction site [polypeptide binding]; other site 443149009401 substrate binding site [chemical binding]; other site 443149009402 aromatic arch; other site 443149009403 Molybdenum cofactor biosynthesis enzyme [Coenzyme metabolism]; Region: MoaA; COG2896 443149009404 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443149009405 FeS/SAM binding site; other site 443149009406 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 443149009407 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 443149009408 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 443149009409 DNA binding site [nucleotide binding] 443149009410 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 443149009411 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 443149009412 phosphopeptide binding site; other site 443149009413 peptide synthase; Provisional; Region: PRK12316 443149009414 putative transposase OrfB; Reviewed; Region: PHA02517 443149009415 HTH-like domain; Region: HTH_21; pfam13276 443149009416 Integrase core domain; Region: rve; pfam00665 443149009417 Integrase core domain; Region: rve_3; pfam13683 443149009418 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 443149009419 Transposase; Region: HTH_Tnp_1; cl17663 443149009420 Transposase; Region: DEDD_Tnp_IS110; pfam01548 443149009421 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 443149009422 Transposase; Region: DEDD_Tnp_IS110; pfam01548 443149009423 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 443149009424 Uncharacterized conserved protein [Function unknown]; Region: COG2128 443149009425 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 443149009426 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443149009427 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443149009428 DNA binding residues [nucleotide binding] 443149009429 SnoaL-like domain; Region: SnoaL_2; pfam12680 443149009430 hypothetical protein; Provisional; Region: PRK06541 443149009431 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 443149009432 inhibitor-cofactor binding pocket; inhibition site 443149009433 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443149009434 catalytic residue [active] 443149009435 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 443149009436 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 443149009437 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 443149009438 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443149009439 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 443149009440 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 443149009441 active site 443149009442 dimer interface [polypeptide binding]; other site 443149009443 Protein of unknown function (DUF732); Region: DUF732; pfam05305 443149009444 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 443149009445 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 443149009446 DNA binding residues [nucleotide binding] 443149009447 dimer interface [polypeptide binding]; other site 443149009448 metal binding site [ion binding]; metal-binding site 443149009449 inner membrane protein YhjD; Region: TIGR00766 443149009450 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 443149009451 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 443149009452 active site 443149009453 HIGH motif; other site 443149009454 dimer interface [polypeptide binding]; other site 443149009455 KMSKS motif; other site 443149009456 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 443149009457 isocitrate dehydrogenase; Validated; Region: PRK08299 443149009458 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 443149009459 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 443149009460 homodimer interface [polypeptide binding]; other site 443149009461 substrate-cofactor binding pocket; other site 443149009462 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443149009463 catalytic residue [active] 443149009464 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 443149009465 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 443149009466 Methyltransferase domain; Region: Methyltransf_23; pfam13489 443149009467 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149009468 S-adenosylmethionine binding site [chemical binding]; other site 443149009469 PPE family; Region: PPE; pfam00823 443149009470 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149009471 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149009472 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009473 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009474 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009475 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149009476 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009477 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009478 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149009479 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009480 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009481 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009482 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149009483 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009484 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009485 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009486 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149009487 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009488 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009489 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009490 PE family; Region: PE; pfam00934 443149009491 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 443149009492 PPE family; Region: PPE; pfam00823 443149009493 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009494 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009495 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149009496 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009497 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009498 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149009499 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009500 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009501 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149009502 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009503 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009504 Transposase; Region: DEDD_Tnp_IS110; pfam01548 443149009505 Transposase; Region: DDE_Tnp_ISL3; pfam01610 443149009506 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149009507 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009508 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009509 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149009510 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009511 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009512 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009513 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009514 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149009515 PPE family; Region: PPE; pfam00823 443149009516 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149009517 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009518 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009519 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149009520 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009521 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009522 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009523 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009524 Berberine and berberine like; Region: BBE; pfam08031 443149009525 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 443149009526 Protein of unknown function (DUF732); Region: DUF732; pfam05305 443149009527 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 443149009528 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 443149009529 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 443149009530 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 443149009531 homodimer interface [polypeptide binding]; other site 443149009532 NADP binding site [chemical binding]; other site 443149009533 substrate binding site [chemical binding]; other site 443149009534 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 443149009535 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 443149009536 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 443149009537 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 443149009538 active site 443149009539 FMN binding site [chemical binding]; other site 443149009540 substrate binding site [chemical binding]; other site 443149009541 putative catalytic residue [active] 443149009542 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 443149009543 phosphate binding site [ion binding]; other site 443149009544 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 443149009545 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 443149009546 phosphopeptide binding site; other site 443149009547 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 443149009548 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 443149009549 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 443149009550 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 443149009551 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 443149009552 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 443149009553 G1 box; other site 443149009554 GTP/Mg2+ binding site [chemical binding]; other site 443149009555 G2 box; other site 443149009556 Switch I region; other site 443149009557 G3 box; other site 443149009558 Switch II region; other site 443149009559 G4 box; other site 443149009560 G5 box; other site 443149009561 Protein of unknown function (DUF742); Region: DUF742; pfam05331 443149009562 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 443149009563 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443149009564 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443149009565 ATP binding site [chemical binding]; other site 443149009566 Mg2+ binding site [ion binding]; other site 443149009567 G-X-G motif; other site 443149009568 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 443149009569 PE family; Region: PE; pfam00934 443149009570 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 443149009571 FMN binding site [chemical binding]; other site 443149009572 dimer interface [polypeptide binding]; other site 443149009573 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 443149009574 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 443149009575 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 443149009576 active site 443149009577 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 443149009578 generic binding surface II; other site 443149009579 generic binding surface I; other site 443149009580 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443149009581 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443149009582 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 443149009583 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 443149009584 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443149009585 active site 443149009586 motif I; other site 443149009587 motif II; other site 443149009588 PE family; Region: PE; pfam00934 443149009589 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443149009590 substrate binding site [chemical binding]; other site 443149009591 oxyanion hole (OAH) forming residues; other site 443149009592 trimer interface [polypeptide binding]; other site 443149009593 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 443149009594 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 443149009595 Amidase; Region: Amidase; pfam01425 443149009596 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 443149009597 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443149009598 motif II; other site 443149009599 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 443149009600 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 443149009601 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12571 443149009602 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 443149009603 TPP-binding site; other site 443149009604 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 443149009605 PYR/PP interface [polypeptide binding]; other site 443149009606 dimer interface [polypeptide binding]; other site 443149009607 TPP binding site [chemical binding]; other site 443149009608 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 443149009609 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 443149009610 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 443149009611 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 443149009612 aspartate-rich region 2; other site 443149009613 substrate-Mg2+ binding site; other site 443149009614 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 443149009615 Transposase; Region: HTH_Tnp_1; cl17663 443149009616 putative transposase OrfB; Reviewed; Region: PHA02517 443149009617 HTH-like domain; Region: HTH_21; pfam13276 443149009618 Integrase core domain; Region: rve; pfam00665 443149009619 Integrase core domain; Region: rve_3; pfam13683 443149009620 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 443149009621 aspartate-rich region 1; other site 443149009622 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 443149009623 putative active site [active] 443149009624 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 443149009625 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 443149009626 Transposase domain (DUF772); Region: DUF772; pfam05598 443149009627 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 443149009628 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 443149009629 PE family; Region: PE; pfam00934 443149009630 enoyl-CoA hydratase; Region: PLN02864 443149009631 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 443149009632 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 443149009633 dimer interaction site [polypeptide binding]; other site 443149009634 substrate-binding tunnel; other site 443149009635 active site 443149009636 catalytic site [active] 443149009637 substrate binding site [chemical binding]; other site 443149009638 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 443149009639 short chain dehydrogenase; Provisional; Region: PRK07201 443149009640 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 443149009641 putative NAD(P) binding site [chemical binding]; other site 443149009642 active site 443149009643 putative substrate binding site [chemical binding]; other site 443149009644 classical (c) SDRs; Region: SDR_c; cd05233 443149009645 NAD(P) binding site [chemical binding]; other site 443149009646 active site 443149009647 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 443149009648 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149009649 S-adenosylmethionine binding site [chemical binding]; other site 443149009650 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 443149009651 active site 443149009652 DNA Polymerase Y-family; Region: PolY_like; cd03468 443149009653 DNA binding site [nucleotide binding] 443149009654 GMP synthase; Reviewed; Region: guaA; PRK00074 443149009655 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 443149009656 AMP/PPi binding site [chemical binding]; other site 443149009657 candidate oxyanion hole; other site 443149009658 catalytic triad [active] 443149009659 potential glutamine specificity residues [chemical binding]; other site 443149009660 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 443149009661 ATP Binding subdomain [chemical binding]; other site 443149009662 Ligand Binding sites [chemical binding]; other site 443149009663 Dimerization subdomain; other site 443149009664 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 443149009665 active site lid residues [active] 443149009666 substrate binding pocket [chemical binding]; other site 443149009667 catalytic residues [active] 443149009668 substrate-Mg2+ binding site; other site 443149009669 aspartate-rich region 1; other site 443149009670 aspartate-rich region 2; other site 443149009671 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 443149009672 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 443149009673 substrate binding pocket [chemical binding]; other site 443149009674 chain length determination region; other site 443149009675 substrate-Mg2+ binding site; other site 443149009676 catalytic residues [active] 443149009677 aspartate-rich region 1; other site 443149009678 active site lid residues [active] 443149009679 aspartate-rich region 2; other site 443149009680 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 443149009681 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 443149009682 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 443149009683 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 443149009684 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 443149009685 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 443149009686 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 443149009687 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 443149009688 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 443149009689 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 443149009690 inhibitor-cofactor binding pocket; inhibition site 443149009691 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443149009692 catalytic residue [active] 443149009693 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 443149009694 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 443149009695 hypothetical protein; Provisional; Region: PRK07579 443149009696 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 443149009697 active site 443149009698 cosubstrate binding site; other site 443149009699 substrate binding site [chemical binding]; other site 443149009700 catalytic site [active] 443149009701 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149009702 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149009703 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 443149009704 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 443149009705 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 443149009706 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 443149009707 putative active site [active] 443149009708 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 443149009709 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 443149009710 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 443149009711 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 443149009712 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 443149009713 phosphate binding site [ion binding]; other site 443149009714 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 443149009715 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 443149009716 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 443149009717 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 443149009718 active site 443149009719 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 443149009720 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443149009721 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443149009722 DNA binding residues [nucleotide binding] 443149009723 Transcription factor WhiB; Region: Whib; pfam02467 443149009724 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 443149009725 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 443149009726 ring oligomerisation interface [polypeptide binding]; other site 443149009727 ATP/Mg binding site [chemical binding]; other site 443149009728 stacking interactions; other site 443149009729 hinge regions; other site 443149009730 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 443149009731 oligomerisation interface [polypeptide binding]; other site 443149009732 mobile loop; other site 443149009733 roof hairpin; other site 443149009734 UGMP family protein; Validated; Region: PRK09604 443149009735 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 443149009736 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 443149009737 Coenzyme A binding pocket [chemical binding]; other site 443149009738 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 443149009739 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 443149009740 alanine racemase; Reviewed; Region: alr; PRK00053 443149009741 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 443149009742 active site 443149009743 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 443149009744 dimer interface [polypeptide binding]; other site 443149009745 substrate binding site [chemical binding]; other site 443149009746 catalytic residues [active] 443149009747 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149009748 PPE family; Region: PPE; pfam00823 443149009749 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149009750 PPE family; Region: PPE; pfam00823 443149009751 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149009752 PPE family; Region: PPE; pfam00823 443149009753 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 443149009754 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443149009755 Walker A motif; other site 443149009756 ATP binding site [chemical binding]; other site 443149009757 Walker B motif; other site 443149009758 arginine finger; other site 443149009759 putative transposase OrfB; Reviewed; Region: PHA02517 443149009760 HTH-like domain; Region: HTH_21; pfam13276 443149009761 Integrase core domain; Region: rve; pfam00665 443149009762 Integrase core domain; Region: rve_3; pfam13683 443149009763 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 443149009764 Transposase; Region: HTH_Tnp_1; cl17663 443149009765 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 443149009766 Integrase core domain; Region: rve; pfam00665 443149009767 PE family; Region: PE; pfam00934 443149009768 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149009769 PPE family; Region: PPE; pfam00823 443149009770 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 443149009771 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149009772 PPE family; Region: PPE; pfam00823 443149009773 Integrase core domain; Region: rve; pfam00665 443149009774 Integrase core domain; Region: rve_3; pfam13683 443149009775 Transposase, Mutator family; Region: Transposase_mut; pfam00872 443149009776 MULE transposase domain; Region: MULE; pfam10551 443149009777 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 443149009778 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443149009779 catalytic residue [active] 443149009780 Uncharacterized conserved protein [Function unknown]; Region: COG0062 443149009781 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 443149009782 putative substrate binding site [chemical binding]; other site 443149009783 putative ATP binding site [chemical binding]; other site 443149009784 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 443149009785 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 443149009786 glutaminase active site [active] 443149009787 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 443149009788 dimer interface [polypeptide binding]; other site 443149009789 active site 443149009790 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 443149009791 dimer interface [polypeptide binding]; other site 443149009792 active site 443149009793 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 443149009794 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 443149009795 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 443149009796 active site 443149009797 substrate binding site [chemical binding]; other site 443149009798 metal binding site [ion binding]; metal-binding site 443149009799 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 443149009800 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 443149009801 23S rRNA interface [nucleotide binding]; other site 443149009802 L3 interface [polypeptide binding]; other site 443149009803 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 443149009804 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 443149009805 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 443149009806 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 443149009807 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 443149009808 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 443149009809 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 443149009810 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 443149009811 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 443149009812 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 443149009813 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 443149009814 active site 443149009815 catalytic residues [active] 443149009816 Protein of unknown function (DUF690); Region: DUF690; pfam05108 443149009817 Cutinase; Region: Cutinase; pfam01083 443149009818 Cutinase; Region: Cutinase; pfam01083 443149009819 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 443149009820 Pseudouridylate synthase [Translation, ribosomal structure and biogenesis]; Region: TruA; COG0101 443149009821 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 443149009822 dimerization interface 3.5A [polypeptide binding]; other site 443149009823 active site 443149009824 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 443149009825 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 443149009826 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 443149009827 alphaNTD - beta interaction site [polypeptide binding]; other site 443149009828 alphaNTD homodimer interface [polypeptide binding]; other site 443149009829 alphaNTD - beta' interaction site [polypeptide binding]; other site 443149009830 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 443149009831 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 443149009832 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 443149009833 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 443149009834 RNA binding surface [nucleotide binding]; other site 443149009835 30S ribosomal protein S11; Validated; Region: PRK05309 443149009836 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 443149009837 30S ribosomal protein S13; Region: bact_S13; TIGR03631 443149009838 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 443149009839 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 443149009840 rRNA binding site [nucleotide binding]; other site 443149009841 predicted 30S ribosome binding site; other site 443149009842 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 443149009843 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 443149009844 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 443149009845 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 443149009846 NAD binding site [chemical binding]; other site 443149009847 substrate binding site [chemical binding]; other site 443149009848 homodimer interface [polypeptide binding]; other site 443149009849 active site 443149009850 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 443149009851 Domain of unknown function (DUF222); Region: DUF222; pfam02720 443149009852 Domain of unknown function (DUF222); Region: DUF222; pfam02720 443149009853 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 443149009854 active site 443149009855 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 443149009856 extended (e) SDRs; Region: SDR_e; cd08946 443149009857 NAD(P) binding site [chemical binding]; other site 443149009858 active site 443149009859 substrate binding site [chemical binding]; other site 443149009860 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 443149009861 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 443149009862 active site 443149009863 catalytic residues [active] 443149009864 metal binding site [ion binding]; metal-binding site 443149009865 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 443149009866 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 443149009867 PYR/PP interface [polypeptide binding]; other site 443149009868 dimer interface [polypeptide binding]; other site 443149009869 TPP binding site [chemical binding]; other site 443149009870 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 443149009871 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 443149009872 TPP-binding site [chemical binding]; other site 443149009873 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 443149009874 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 443149009875 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443149009876 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 443149009877 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443149009878 metabolite-proton symporter; Region: 2A0106; TIGR00883 443149009879 putative substrate translocation pore; other site 443149009880 PE family; Region: PE; pfam00934 443149009881 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149009882 PPE family; Region: PPE; pfam00823 443149009883 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 443149009884 patatin-related protein; Region: TIGR03607 443149009885 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443149009886 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443149009887 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 443149009888 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 443149009889 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 443149009890 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 443149009891 Transcriptional regulator [Transcription]; Region: LytR; COG1316 443149009892 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 443149009893 short chain dehydrogenase; Provisional; Region: PRK05875 443149009894 classical (c) SDRs; Region: SDR_c; cd05233 443149009895 NAD(P) binding site [chemical binding]; other site 443149009896 active site 443149009897 Predicted membrane protein [Function unknown]; Region: COG2259 443149009898 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 443149009899 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 443149009900 Predicted transcriptional regulators [Transcription]; Region: COG1695 443149009901 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 443149009902 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 443149009903 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 443149009904 active site 443149009905 homotetramer interface [polypeptide binding]; other site 443149009906 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443149009907 mce related protein; Region: MCE; pfam02470 443149009908 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443149009909 mce related protein; Region: MCE; pfam02470 443149009910 mce related protein; Region: MCE; pfam02470 443149009911 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443149009912 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 443149009913 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443149009914 mce related protein; Region: MCE; pfam02470 443149009915 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443149009916 mce related protein; Region: MCE; pfam02470 443149009917 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443149009918 mce related protein; Region: MCE; pfam02470 443149009919 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 443149009920 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 443149009921 Permease; Region: Permease; pfam02405 443149009922 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 443149009923 Permease; Region: Permease; pfam02405 443149009924 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 443149009925 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443149009926 NAD(P) binding site [chemical binding]; other site 443149009927 active site 443149009928 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 443149009929 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 443149009930 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149009931 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 443149009932 FAD binding site [chemical binding]; other site 443149009933 substrate binding site [chemical binding]; other site 443149009934 catalytic base [active] 443149009935 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149009936 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443149009937 active site 443149009938 acyl-CoA synthetase; Validated; Region: PRK07867 443149009939 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 443149009940 acyl-activating enzyme (AAE) consensus motif; other site 443149009941 putative AMP binding site [chemical binding]; other site 443149009942 putative active site [active] 443149009943 putative CoA binding site [chemical binding]; other site 443149009944 PE family; Region: PE; pfam00934 443149009945 PE family; Region: PE; pfam00934 443149009946 hypothetical protein; Validated; Region: PRK07586 443149009947 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 443149009948 PYR/PP interface [polypeptide binding]; other site 443149009949 dimer interface [polypeptide binding]; other site 443149009950 TPP binding site [chemical binding]; other site 443149009951 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 443149009952 TPP-binding site [chemical binding]; other site 443149009953 dimer interface [polypeptide binding]; other site 443149009954 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 443149009955 PE family; Region: PE; pfam00934 443149009956 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443149009957 CoA binding site [chemical binding]; other site 443149009958 PE family; Region: PE; pfam00934 443149009959 acyl-CoA synthetase; Validated; Region: PRK07798 443149009960 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443149009961 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 443149009962 acyl-activating enzyme (AAE) consensus motif; other site 443149009963 acyl-activating enzyme (AAE) consensus motif; other site 443149009964 putative AMP binding site [chemical binding]; other site 443149009965 putative active site [active] 443149009966 putative CoA binding site [chemical binding]; other site 443149009967 enoyl-CoA hydratase; Provisional; Region: PRK07799 443149009968 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443149009969 substrate binding site [chemical binding]; other site 443149009970 oxyanion hole (OAH) forming residues; other site 443149009971 trimer interface [polypeptide binding]; other site 443149009972 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 443149009973 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443149009974 Cytochrome P450; Region: p450; cl12078 443149009975 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 443149009976 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 443149009977 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 443149009978 DUF35 OB-fold domain; Region: DUF35; pfam01796 443149009979 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 443149009980 DUF35 OB-fold domain; Region: DUF35; pfam01796 443149009981 lipid-transfer protein; Provisional; Region: PRK07937 443149009982 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 443149009983 active site 443149009984 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 443149009985 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 443149009986 active site 443149009987 NHL repeat; Region: NHL; pfam01436 443149009988 Uncharacterized conserved protein [Function unknown]; Region: COG3391 443149009989 NHL repeat; Region: NHL; pfam01436 443149009990 NHL repeat; Region: NHL; pfam01436 443149009991 NHL repeat; Region: NHL; pfam01436 443149009992 NHL repeat; Region: NHL; pfam01436 443149009993 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 443149009994 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 443149009995 trimer interface [polypeptide binding]; other site 443149009996 putative metal binding site [ion binding]; other site 443149009997 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 443149009998 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 443149009999 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 443149010000 short chain dehydrogenase; Provisional; Region: PRK07890 443149010001 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443149010002 NAD(P) binding site [chemical binding]; other site 443149010003 active site 443149010004 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149010005 PPE family; Region: PPE; pfam00823 443149010006 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 443149010007 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149010008 PPE family; Region: PPE; pfam00823 443149010009 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149010010 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149010011 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 443149010012 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 443149010013 active site 443149010014 catalytic residues [active] 443149010015 metal binding site [ion binding]; metal-binding site 443149010016 DmpG-like communication domain; Region: DmpG_comm; pfam07836 443149010017 acetaldehyde dehydrogenase; Validated; Region: PRK08300 443149010018 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 443149010019 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 443149010020 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971 443149010021 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 443149010022 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 443149010023 enoyl-CoA hydratase; Region: PLN02864 443149010024 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 443149010025 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 443149010026 dimer interaction site [polypeptide binding]; other site 443149010027 substrate-binding tunnel; other site 443149010028 active site 443149010029 catalytic site [active] 443149010030 substrate binding site [chemical binding]; other site 443149010031 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149010032 PPE family; Region: PPE; pfam00823 443149010033 PE-PPE domain; Region: PE-PPE; pfam08237 443149010034 lipid-transfer protein; Provisional; Region: PRK07855 443149010035 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 443149010036 active site 443149010037 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 443149010038 putative active site [active] 443149010039 putative catalytic site [active] 443149010040 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 443149010041 active site 443149010042 catalytic site [active] 443149010043 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 443149010044 DUF35 OB-fold domain; Region: DUF35; pfam01796 443149010045 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149010046 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443149010047 active site 443149010048 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149010049 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 443149010050 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443149010051 active site 443149010052 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443149010053 Cytochrome P450; Region: p450; cl12078 443149010054 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 443149010055 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 443149010056 dimer interface [polypeptide binding]; other site 443149010057 active site 443149010058 Domain of unknown function (DUF385); Region: DUF385; pfam04075 443149010059 short chain dehydrogenase; Provisional; Region: PRK07791 443149010060 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 443149010061 homodimer interface [polypeptide binding]; other site 443149010062 NAD binding site [chemical binding]; other site 443149010063 active site 443149010064 short chain dehydrogenase; Provisional; Region: PRK07856 443149010065 classical (c) SDRs; Region: SDR_c; cd05233 443149010066 NAD(P) binding site [chemical binding]; other site 443149010067 active site 443149010068 enoyl-CoA hydratase; Provisional; Region: PRK06495 443149010069 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443149010070 substrate binding site [chemical binding]; other site 443149010071 oxyanion hole (OAH) forming residues; other site 443149010072 trimer interface [polypeptide binding]; other site 443149010073 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 443149010074 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057 443149010075 Nitronate monooxygenase; Region: NMO; pfam03060 443149010076 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 443149010077 FMN binding site [chemical binding]; other site 443149010078 substrate binding site [chemical binding]; other site 443149010079 putative catalytic residue [active] 443149010080 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 443149010081 Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514 443149010082 putative di-iron ligands [ion binding]; other site 443149010083 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 443149010084 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 443149010085 FAD binding pocket [chemical binding]; other site 443149010086 FAD binding motif [chemical binding]; other site 443149010087 phosphate binding motif [ion binding]; other site 443149010088 beta-alpha-beta structure motif; other site 443149010089 NAD(p) ribose binding residues [chemical binding]; other site 443149010090 NAD binding pocket [chemical binding]; other site 443149010091 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 443149010092 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443149010093 catalytic loop [active] 443149010094 iron binding site [ion binding]; other site 443149010095 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 443149010096 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 443149010097 putative active site [active] 443149010098 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 443149010099 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 443149010100 dimer interface [polypeptide binding]; other site 443149010101 active site 443149010102 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149010103 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149010104 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149010105 PPE family; Region: PPE; pfam00823 443149010106 short chain dehydrogenase; Provisional; Region: PRK07831 443149010107 classical (c) SDRs; Region: SDR_c; cd05233 443149010108 NAD(P) binding site [chemical binding]; other site 443149010109 active site 443149010110 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149010111 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443149010112 active site 443149010113 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 443149010114 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443149010115 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 443149010116 acyl-activating enzyme (AAE) consensus motif; other site 443149010117 putative AMP binding site [chemical binding]; other site 443149010118 putative active site [active] 443149010119 putative CoA binding site [chemical binding]; other site 443149010120 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149010121 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443149010122 active site 443149010123 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149010124 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 443149010125 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443149010126 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149010127 active site 443149010128 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 443149010129 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443149010130 active site 443149010131 aspartate aminotransferase; Provisional; Region: PRK05764 443149010132 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443149010133 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443149010134 homodimer interface [polypeptide binding]; other site 443149010135 catalytic residue [active] 443149010136 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 443149010137 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 443149010138 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 443149010139 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 443149010140 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 443149010141 active site 443149010142 Fe binding site [ion binding]; other site 443149010143 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 443149010144 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149010145 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 443149010146 Flavin binding site [chemical binding]; other site 443149010147 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 443149010148 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 443149010149 FAD binding pocket [chemical binding]; other site 443149010150 FAD binding motif [chemical binding]; other site 443149010151 phosphate binding motif [ion binding]; other site 443149010152 beta-alpha-beta structure motif; other site 443149010153 NAD(p) ribose binding residues [chemical binding]; other site 443149010154 NAD binding pocket [chemical binding]; other site 443149010155 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 443149010156 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 443149010157 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443149010158 catalytic loop [active] 443149010159 iron binding site [ion binding]; other site 443149010160 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149010161 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443149010162 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443149010163 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149010164 active site 443149010165 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149010166 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149010167 Transcriptional regulators [Transcription]; Region: PurR; COG1609 443149010168 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 443149010169 DNA binding site [nucleotide binding] 443149010170 domain linker motif; other site 443149010171 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 443149010172 putative dimerization interface [polypeptide binding]; other site 443149010173 putative ligand binding site [chemical binding]; other site 443149010174 PknH-like extracellular domain; Region: PknH_C; pfam14032 443149010175 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 443149010176 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 443149010177 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 443149010178 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 443149010179 transmembrane helices; other site 443149010180 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 443149010181 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 443149010182 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 443149010183 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 443149010184 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 443149010185 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 443149010186 active site 443149010187 HIGH motif; other site 443149010188 nucleotide binding site [chemical binding]; other site 443149010189 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 443149010190 KMSKS motif; other site 443149010191 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 443149010192 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 443149010193 homotrimer interaction site [polypeptide binding]; other site 443149010194 zinc binding site [ion binding]; other site 443149010195 CDP-binding sites; other site 443149010196 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 443149010197 substrate binding site; other site 443149010198 dimer interface; other site 443149010199 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 443149010200 DNA repair protein RadA; Provisional; Region: PRK11823 443149010201 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 443149010202 Walker A motif/ATP binding site; other site 443149010203 ATP binding site [chemical binding]; other site 443149010204 Walker B motif; other site 443149010205 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 443149010206 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 443149010207 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 443149010208 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 443149010209 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 443149010210 active site clefts [active] 443149010211 zinc binding site [ion binding]; other site 443149010212 dimer interface [polypeptide binding]; other site 443149010213 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 443149010214 endonuclease III; Region: ENDO3c; smart00478 443149010215 minor groove reading motif; other site 443149010216 helix-hairpin-helix signature motif; other site 443149010217 substrate binding pocket [chemical binding]; other site 443149010218 active site 443149010219 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 443149010220 PE family; Region: PE; pfam00934 443149010221 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443149010222 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 443149010223 catalytic site [active] 443149010224 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 443149010225 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 443149010226 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 443149010227 Ami_2 domain; Region: Ami_2; smart00644 443149010228 amidase catalytic site [active] 443149010229 Zn binding residues [ion binding]; other site 443149010230 substrate binding site [chemical binding]; other site 443149010231 PE family; Region: PE; pfam00934 443149010232 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 443149010233 Clp amino terminal domain; Region: Clp_N; pfam02861 443149010234 Clp amino terminal domain; Region: Clp_N; pfam02861 443149010235 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443149010236 Walker A motif; other site 443149010237 ATP binding site [chemical binding]; other site 443149010238 Walker B motif; other site 443149010239 arginine finger; other site 443149010240 UvrB/uvrC motif; Region: UVR; pfam02151 443149010241 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443149010242 Walker A motif; other site 443149010243 ATP binding site [chemical binding]; other site 443149010244 Walker B motif; other site 443149010245 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 443149010246 Lsr2; Region: Lsr2; pfam11774 443149010247 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 443149010248 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 443149010249 dimer interface [polypeptide binding]; other site 443149010250 putative anticodon binding site; other site 443149010251 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 443149010252 motif 1; other site 443149010253 dimer interface [polypeptide binding]; other site 443149010254 active site 443149010255 motif 2; other site 443149010256 motif 3; other site 443149010257 pantothenate kinase; Reviewed; Region: PRK13318 443149010258 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 443149010259 tetramerization interface [polypeptide binding]; other site 443149010260 active site 443149010261 Pantoate-beta-alanine ligase; Region: PanC; cd00560 443149010262 pantoate--beta-alanine ligase; Region: panC; TIGR00018 443149010263 active site 443149010264 ATP-binding site [chemical binding]; other site 443149010265 pantoate-binding site; other site 443149010266 HXXH motif; other site 443149010267 Rossmann-like domain; Region: Rossmann-like; pfam10727 443149010268 Uncharacterized conserved protein [Function unknown]; Region: COG5495 443149010269 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 443149010270 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 443149010271 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 443149010272 catalytic center binding site [active] 443149010273 ATP binding site [chemical binding]; other site 443149010274 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 443149010275 homooctamer interface [polypeptide binding]; other site 443149010276 active site 443149010277 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 443149010278 dihydropteroate synthase; Region: DHPS; TIGR01496 443149010279 substrate binding pocket [chemical binding]; other site 443149010280 dimer interface [polypeptide binding]; other site 443149010281 inhibitor binding site; inhibition site 443149010282 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 443149010283 homodecamer interface [polypeptide binding]; other site 443149010284 GTP cyclohydrolase I; Provisional; Region: PLN03044 443149010285 active site 443149010286 putative catalytic site residues [active] 443149010287 zinc binding site [ion binding]; other site 443149010288 GTP-CH-I/GFRP interaction surface; other site 443149010289 FtsH Extracellular; Region: FtsH_ext; pfam06480 443149010290 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 443149010291 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443149010292 Walker A motif; other site 443149010293 ATP binding site [chemical binding]; other site 443149010294 Walker B motif; other site 443149010295 arginine finger; other site 443149010296 Peptidase family M41; Region: Peptidase_M41; pfam01434 443149010297 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 443149010298 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 443149010299 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443149010300 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 443149010301 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 443149010302 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 443149010303 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 443149010304 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 443149010305 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 443149010306 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149010307 PPE family; Region: PPE; pfam00823 443149010308 PE family; Region: PE; pfam00934 443149010309 Uncharacterized conserved protein [Function unknown]; Region: COG2968 443149010310 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 443149010311 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 443149010312 active site 443149010313 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 443149010314 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 443149010315 Ligand Binding Site [chemical binding]; other site 443149010316 Uncharacterized conserved protein [Function unknown]; Region: COG5282 443149010317 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 443149010318 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113 443149010319 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 443149010320 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 443149010321 dimer interface [polypeptide binding]; other site 443149010322 substrate binding site [chemical binding]; other site 443149010323 metal binding sites [ion binding]; metal-binding site 443149010324 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2899 443149010325 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 443149010326 Ligand binding site; other site 443149010327 Putative Catalytic site; other site 443149010328 DXD motif; other site 443149010329 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 443149010330 Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5285 443149010331 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 443149010332 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443149010333 NAD(P) binding site [chemical binding]; other site 443149010334 active site 443149010335 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 443149010336 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 443149010337 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 443149010338 transposase; Provisional; Region: PRK06526 443149010339 IstB-like ATP binding protein; Region: IstB_IS21; pfam01695 443149010340 Walker B motif; other site 443149010341 Transposase, Mutator family; Region: Transposase_mut; pfam00872 443149010342 MULE transposase domain; Region: MULE; pfam10551 443149010343 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 443149010344 Fic/DOC family; Region: Fic; cl00960 443149010345 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 443149010346 DNA polymerase III subunit delta'; Validated; Region: PRK07940 443149010347 DNA polymerase III subunit delta'; Validated; Region: PRK08485 443149010348 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443149010349 dimerization interface [polypeptide binding]; other site 443149010350 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 443149010351 cyclase homology domain; Region: CHD; cd07302 443149010352 nucleotidyl binding site; other site 443149010353 metal binding site [ion binding]; metal-binding site 443149010354 dimer interface [polypeptide binding]; other site 443149010355 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 443149010356 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 443149010357 active site 443149010358 interdomain interaction site; other site 443149010359 putative metal-binding site [ion binding]; other site 443149010360 nucleotide binding site [chemical binding]; other site 443149010361 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 443149010362 domain I; other site 443149010363 phosphate binding site [ion binding]; other site 443149010364 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 443149010365 domain II; other site 443149010366 domain III; other site 443149010367 nucleotide binding site [chemical binding]; other site 443149010368 DNA binding groove [nucleotide binding] 443149010369 catalytic site [active] 443149010370 domain IV; other site 443149010371 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 443149010372 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 443149010373 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 443149010374 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 443149010375 DNA-binding site [nucleotide binding]; DNA binding site 443149010376 RNA-binding motif; other site 443149010377 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 443149010378 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443149010379 ATP binding site [chemical binding]; other site 443149010380 putative Mg++ binding site [ion binding]; other site 443149010381 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443149010382 nucleotide binding region [chemical binding]; other site 443149010383 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 443149010384 PE family; Region: PE; pfam00934 443149010385 PE family; Region: PE; pfam00934 443149010386 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 443149010387 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 443149010388 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 443149010389 Walker A motif; other site 443149010390 ATP binding site [chemical binding]; other site 443149010391 Walker B motif; other site 443149010392 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 443149010393 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 443149010394 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443149010395 motif II; other site 443149010396 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 443149010397 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 443149010398 Walker A/P-loop; other site 443149010399 ATP binding site [chemical binding]; other site 443149010400 Q-loop/lid; other site 443149010401 ABC transporter signature motif; other site 443149010402 Walker B; other site 443149010403 D-loop; other site 443149010404 H-loop/switch region; other site 443149010405 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 443149010406 Walker A/P-loop; other site 443149010407 ATP binding site [chemical binding]; other site 443149010408 Q-loop/lid; other site 443149010409 ABC transporter signature motif; other site 443149010410 Walker B; other site 443149010411 D-loop; other site 443149010412 H-loop/switch region; other site 443149010413 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 443149010414 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 443149010415 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443149010416 ABC-ATPase subunit interface; other site 443149010417 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 443149010418 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443149010419 dimer interface [polypeptide binding]; other site 443149010420 conserved gate region; other site 443149010421 ABC-ATPase subunit interface; other site 443149010422 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 443149010423 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 443149010424 acetyl-CoA synthetase; Provisional; Region: PRK00174 443149010425 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 443149010426 active site 443149010427 CoA binding site [chemical binding]; other site 443149010428 acyl-activating enzyme (AAE) consensus motif; other site 443149010429 AMP binding site [chemical binding]; other site 443149010430 acetate binding site [chemical binding]; other site 443149010431 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 443149010432 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443149010433 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 443149010434 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 443149010435 putative active site [active] 443149010436 putative CoA binding site [chemical binding]; other site 443149010437 nudix motif; other site 443149010438 metal binding site [ion binding]; metal-binding site 443149010439 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 443149010440 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 443149010441 catalytic residues [active] 443149010442 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 443149010443 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 443149010444 minor groove reading motif; other site 443149010445 helix-hairpin-helix signature motif; other site 443149010446 substrate binding pocket [chemical binding]; other site 443149010447 active site 443149010448 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 443149010449 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 443149010450 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 443149010451 ligand binding site [chemical binding]; other site 443149010452 flexible hinge region; other site 443149010453 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 443149010454 putative switch regulator; other site 443149010455 non-specific DNA interactions [nucleotide binding]; other site 443149010456 DNA binding site [nucleotide binding] 443149010457 sequence specific DNA binding site [nucleotide binding]; other site 443149010458 putative cAMP binding site [chemical binding]; other site 443149010459 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 443149010460 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 443149010461 homotrimer interaction site [polypeptide binding]; other site 443149010462 putative active site [active] 443149010463 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 443149010464 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 443149010465 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 443149010466 P loop; other site 443149010467 Nucleotide binding site [chemical binding]; other site 443149010468 DTAP/Switch II; other site 443149010469 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 443149010470 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 443149010471 DTAP/Switch II; other site 443149010472 Switch I; other site 443149010473 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 443149010474 Transcription factor WhiB; Region: Whib; pfam02467 443149010475 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 443149010476 Transglycosylase; Region: Transgly; pfam00912 443149010477 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 443149010478 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 443149010479 phosphodiesterase YaeI; Provisional; Region: PRK11340 443149010480 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 443149010481 putative active site [active] 443149010482 putative metal binding site [ion binding]; other site 443149010483 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 443149010484 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 443149010485 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443149010486 catalytic residue [active] 443149010487 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443149010488 Cytochrome P450; Region: p450; cl12078 443149010489 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 443149010490 anti sigma factor interaction site; other site 443149010491 regulatory phosphorylation site [posttranslational modification]; other site 443149010492 Uncharacterized conserved protein [Function unknown]; Region: COG1610 443149010493 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 443149010494 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 443149010495 MoxR-like ATPases [General function prediction only]; Region: COG0714 443149010496 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443149010497 Walker A motif; other site 443149010498 ATP binding site [chemical binding]; other site 443149010499 Walker B motif; other site 443149010500 arginine finger; other site 443149010501 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 443149010502 Protein of unknown function DUF58; Region: DUF58; pfam01882 443149010503 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 443149010504 Predicted membrane protein/domain [Function unknown]; Region: COG1714 443149010505 glycerol kinase; Provisional; Region: glpK; PRK00047 443149010506 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 443149010507 nucleotide binding site [chemical binding]; other site 443149010508 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 443149010509 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 443149010510 Methyltransferase domain; Region: Methyltransf_23; pfam13489 443149010511 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149010512 S-adenosylmethionine binding site [chemical binding]; other site 443149010513 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 443149010514 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 443149010515 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443149010516 catalytic residue [active] 443149010517 Uncharacterized conserved protein [Function unknown]; Region: COG4301 443149010518 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 443149010519 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 443149010520 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 443149010521 putative active site [active] 443149010522 putative dimer interface [polypeptide binding]; other site 443149010523 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 443149010524 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 443149010525 Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG3572 443149010526 PknH-like extracellular domain; Region: PknH_C; pfam14032 443149010527 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 443149010528 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 443149010529 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 443149010530 aspartate kinase; Reviewed; Region: PRK06635 443149010531 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 443149010532 putative nucleotide binding site [chemical binding]; other site 443149010533 putative catalytic residues [active] 443149010534 putative Mg ion binding site [ion binding]; other site 443149010535 putative aspartate binding site [chemical binding]; other site 443149010536 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 443149010537 putative allosteric regulatory site; other site 443149010538 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 443149010539 putative allosteric regulatory residue; other site 443149010540 2-isopropylmalate synthase; Validated; Region: PRK03739 443149010541 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 443149010542 active site 443149010543 catalytic residues [active] 443149010544 metal binding site [ion binding]; metal-binding site 443149010545 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 443149010546 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 443149010547 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 443149010548 active site 443149010549 catalytic site [active] 443149010550 substrate binding site [chemical binding]; other site 443149010551 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 443149010552 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 443149010553 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 443149010554 catalytic triad [active] 443149010555 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 443149010556 putative active site [active] 443149010557 recombination protein RecR; Reviewed; Region: recR; PRK00076 443149010558 RecR protein; Region: RecR; pfam02132 443149010559 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 443149010560 putative active site [active] 443149010561 putative metal-binding site [ion binding]; other site 443149010562 tetramer interface [polypeptide binding]; other site 443149010563 hypothetical protein; Validated; Region: PRK00153 443149010564 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 443149010565 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 443149010566 active site 443149010567 metal binding site [ion binding]; metal-binding site 443149010568 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 443149010569 hydrophobic ligand binding site; other site 443149010570 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 443149010571 FAD binding domain; Region: FAD_binding_4; pfam01565 443149010572 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 443149010573 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149010574 S-adenosylmethionine binding site [chemical binding]; other site 443149010575 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14952 443149010576 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443149010577 Walker A motif; other site 443149010578 ATP binding site [chemical binding]; other site 443149010579 Walker B motif; other site 443149010580 arginine finger; other site 443149010581 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 443149010582 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 443149010583 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 443149010584 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443149010585 catalytic residue [active] 443149010586 Cutinase; Region: Cutinase; pfam01083 443149010587 Cutinase; Region: Cutinase; pfam01083 443149010588 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 443149010589 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443149010590 NAD(P) binding site [chemical binding]; other site 443149010591 active site 443149010592 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 443149010593 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 443149010594 putative NAD(P) binding site [chemical binding]; other site 443149010595 catalytic Zn binding site [ion binding]; other site 443149010596 Uncharacterized conserved protein [Function unknown]; Region: COG3349 443149010597 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 443149010598 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 443149010599 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443149010600 putative substrate translocation pore; other site 443149010601 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 443149010602 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 443149010603 ligand binding site [chemical binding]; other site 443149010604 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 443149010605 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 443149010606 active site 443149010607 nucleophile elbow; other site 443149010608 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 443149010609 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443149010610 FeS/SAM binding site; other site 443149010611 Methyltransferase domain; Region: Methyltransf_31; pfam13847 443149010612 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149010613 S-adenosylmethionine binding site [chemical binding]; other site 443149010614 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 443149010615 nucleotide binding site [chemical binding]; other site 443149010616 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 443149010617 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 443149010618 active site 443149010619 DNA binding site [nucleotide binding] 443149010620 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 443149010621 DNA binding site [nucleotide binding] 443149010622 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4402 443149010623 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_5; cd04662 443149010624 nudix motif; other site 443149010625 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443149010626 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443149010627 Uncharacterized conserved protein [Function unknown]; Region: COG1839 443149010628 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 443149010629 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 443149010630 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 443149010631 Uncharacterized conserved protein [Function unknown]; Region: COG2966 443149010632 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 443149010633 Uncharacterized conserved protein [Function unknown]; Region: COG3610 443149010634 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149010635 PPE family; Region: PPE; pfam00823 443149010636 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149010637 PPE family; Region: PPE; pfam00823 443149010638 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443149010639 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443149010640 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 443149010641 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 443149010642 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 443149010643 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 443149010644 Soluble P-type ATPase [General function prediction only]; Region: COG4087 443149010645 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 443149010646 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 443149010647 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443149010648 dimerization interface [polypeptide binding]; other site 443149010649 putative DNA binding site [nucleotide binding]; other site 443149010650 putative Zn2+ binding site [ion binding]; other site 443149010651 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3651 443149010652 DNA binding domain, excisionase family; Region: excise; TIGR01764 443149010653 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 443149010654 active site 443149010655 Int/Topo IB signature motif; other site 443149010656 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 443149010657 nucleoside/Zn binding site; other site 443149010658 dimer interface [polypeptide binding]; other site 443149010659 catalytic motif [active] 443149010660 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 443149010661 prephenate dehydrogenase; Validated; Region: PRK06545 443149010662 prephenate dehydrogenase; Validated; Region: PRK08507 443149010663 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3554 443149010664 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443149010665 ABC-ATPase subunit interface; other site 443149010666 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 443149010667 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 443149010668 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 443149010669 Walker A/P-loop; other site 443149010670 ATP binding site [chemical binding]; other site 443149010671 Q-loop/lid; other site 443149010672 ABC transporter signature motif; other site 443149010673 Walker B; other site 443149010674 D-loop; other site 443149010675 H-loop/switch region; other site 443149010676 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 443149010677 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 443149010678 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 443149010679 putative active site [active] 443149010680 putative substrate binding site [chemical binding]; other site 443149010681 ATP binding site [chemical binding]; other site 443149010682 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 443149010683 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 443149010684 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 443149010685 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443149010686 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 443149010687 dimerization interface [polypeptide binding]; other site 443149010688 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443149010689 dimer interface [polypeptide binding]; other site 443149010690 phosphorylation site [posttranslational modification] 443149010691 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443149010692 ATP binding site [chemical binding]; other site 443149010693 Mg2+ binding site [ion binding]; other site 443149010694 G-X-G motif; other site 443149010695 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 443149010696 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443149010697 active site 443149010698 phosphorylation site [posttranslational modification] 443149010699 intermolecular recognition site; other site 443149010700 dimerization interface [polypeptide binding]; other site 443149010701 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443149010702 DNA binding site [nucleotide binding] 443149010703 Photosystem II reaction centre W protein (PsbW); Region: PsbW; cl06243 443149010704 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 443149010705 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 443149010706 SnoaL-like domain; Region: SnoaL_2; pfam12680 443149010707 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 443149010708 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443149010709 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443149010710 homodimer interface [polypeptide binding]; other site 443149010711 catalytic residue [active] 443149010712 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 443149010713 TIGR03086 family protein; Region: TIGR03086 443149010714 enoyl-CoA hydratase; Provisional; Region: PRK06142 443149010715 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443149010716 substrate binding site [chemical binding]; other site 443149010717 oxyanion hole (OAH) forming residues; other site 443149010718 trimer interface [polypeptide binding]; other site 443149010719 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 443149010720 Beta-lactamase; Region: Beta-lactamase; pfam00144 443149010721 Domain of unknown function (DUF222); Region: DUF222; pfam02720 443149010722 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 443149010723 active site 443149010724 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 443149010725 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 443149010726 NAD(P) binding site [chemical binding]; other site 443149010727 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 443149010728 cysteine desulfurase family protein, VC1184 subfamily; Region: am_tr_V_VC1184; TIGR01976 443149010729 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443149010730 catalytic residue [active] 443149010731 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 443149010732 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 443149010733 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 443149010734 Walker A/P-loop; other site 443149010735 ATP binding site [chemical binding]; other site 443149010736 Q-loop/lid; other site 443149010737 ABC transporter signature motif; other site 443149010738 Walker B; other site 443149010739 D-loop; other site 443149010740 H-loop/switch region; other site 443149010741 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 443149010742 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 443149010743 active site 443149010744 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 443149010745 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 443149010746 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 443149010747 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 443149010748 NAD binding site [chemical binding]; other site 443149010749 substrate binding site [chemical binding]; other site 443149010750 active site 443149010751 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 443149010752 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 443149010753 active site 443149010754 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 443149010755 Peptidase family M23; Region: Peptidase_M23; pfam01551 443149010756 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 443149010757 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 443149010758 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05892 443149010759 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 443149010760 Predicted membrane protein [Function unknown]; Region: COG2246 443149010761 GtrA-like protein; Region: GtrA; pfam04138 443149010762 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 443149010763 FAD binding domain; Region: FAD_binding_4; pfam01565 443149010764 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 443149010765 short chain dehydrogenase; Provisional; Region: PRK07904 443149010766 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 443149010767 NAD(P) binding site [chemical binding]; other site 443149010768 active site 443149010769 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 443149010770 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 443149010771 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 443149010772 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 443149010773 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 443149010774 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 443149010775 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 443149010776 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149010777 FAD binding site [chemical binding]; other site 443149010778 substrate binding site [chemical binding]; other site 443149010779 catalytic residues [active] 443149010780 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 443149010781 Transposase; Region: DDE_Tnp_ISL3; pfam01610 443149010782 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 443149010783 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 443149010784 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 443149010785 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 443149010786 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 443149010787 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 443149010788 active site 443149010789 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 443149010790 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 443149010791 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 443149010792 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 443149010793 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 443149010794 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 443149010795 acyl-activating enzyme (AAE) consensus motif; other site 443149010796 active site 443149010797 Cutinase; Region: Cutinase; pfam01083 443149010798 Predicted esterase [General function prediction only]; Region: COG0627 443149010799 Putative esterase; Region: Esterase; pfam00756 443149010800 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 443149010801 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 443149010802 active site 443149010803 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 443149010804 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 443149010805 active site 443149010806 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 443149010807 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 443149010808 UDP-galactopyranose mutase; Region: GLF; pfam03275 443149010809 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 443149010810 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 443149010811 amidase catalytic site [active] 443149010812 Zn binding residues [ion binding]; other site 443149010813 substrate binding site [chemical binding]; other site 443149010814 LGFP repeat; Region: LGFP; pfam08310 443149010815 PE family; Region: PE; pfam00934 443149010816 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443149010817 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 443149010818 active site 443149010819 motif I; other site 443149010820 motif II; other site 443149010821 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 443149010822 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 443149010823 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 443149010824 putative acyl-acceptor binding pocket; other site 443149010825 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 443149010826 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 443149010827 putative acyl-acceptor binding pocket; other site 443149010828 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 443149010829 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 443149010830 putative acyl-acceptor binding pocket; other site 443149010831 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 443149010832 Phosphotransferase enzyme family; Region: APH; pfam01636 443149010833 active site 443149010834 ATP binding site [chemical binding]; other site 443149010835 antibiotic binding site [chemical binding]; other site 443149010836 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 443149010837 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 443149010838 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 443149010839 iron-sulfur cluster [ion binding]; other site 443149010840 [2Fe-2S] cluster binding site [ion binding]; other site 443149010841 Condensation domain; Region: Condensation; pfam00668 443149010842 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 443149010843 PE-PPE domain; Region: PE-PPE; pfam08237 443149010844 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 443149010845 Condensation domain; Region: Condensation; pfam00668 443149010846 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 443149010847 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443149010848 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 443149010849 Enoylreductase; Region: PKS_ER; smart00829 443149010850 NAD(P) binding site [chemical binding]; other site 443149010851 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 443149010852 KR domain; Region: KR; pfam08659 443149010853 putative NADP binding site [chemical binding]; other site 443149010854 active site 443149010855 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 443149010856 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 443149010857 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 443149010858 active site 443149010859 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 443149010860 acyl-CoA synthetase; Validated; Region: PRK05850 443149010861 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 443149010862 acyl-activating enzyme (AAE) consensus motif; other site 443149010863 active site 443149010864 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 443149010865 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 443149010866 Probable transposase; Region: OrfB_IS605; pfam01385 443149010867 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 443149010868 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 443149010869 catalytic residues [active] 443149010870 catalytic nucleophile [active] 443149010871 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 443149010872 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149010873 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 443149010874 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 443149010875 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 443149010876 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149010877 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 443149010878 Cupin domain; Region: Cupin_2; cl17218 443149010879 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 443149010880 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 443149010881 seryl-tRNA synthetase; Provisional; Region: PRK05431 443149010882 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 443149010883 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 443149010884 dimer interface [polypeptide binding]; other site 443149010885 active site 443149010886 motif 1; other site 443149010887 motif 2; other site 443149010888 motif 3; other site 443149010889 Septum formation; Region: Septum_form; pfam13845 443149010890 Septum formation; Region: Septum_form; pfam13845 443149010891 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 443149010892 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 443149010893 catalytic core [active] 443149010894 prephenate dehydratase; Provisional; Region: PRK11898 443149010895 Prephenate dehydratase; Region: PDT; pfam00800 443149010896 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 443149010897 putative L-Phe binding site [chemical binding]; other site 443149010898 Transcriptional regulator [Transcription]; Region: LytR; COG1316 443149010899 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 443149010900 Ferritin-like domain; Region: Ferritin; pfam00210 443149010901 ferroxidase diiron center [ion binding]; other site 443149010902 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 443149010903 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 443149010904 putative active site [active] 443149010905 catalytic site [active] 443149010906 putative metal binding site [ion binding]; other site 443149010907 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 443149010908 Transposase; Region: DEDD_Tnp_IS110; pfam01548 443149010909 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 443149010910 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 443149010911 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 443149010912 Predicted membrane protein [Function unknown]; Region: COG2119 443149010913 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 443149010914 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 443149010915 Fimbrial protein; Region: Fimbrial; cl01416 443149010916 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 443149010917 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 443149010918 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 443149010919 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149010920 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149010921 hypothetical protein; Provisional; Region: PRK07945 443149010922 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 443149010923 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 443149010924 active site 443149010925 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 443149010926 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 443149010927 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 443149010928 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 443149010929 active site 443149010930 dimer interface [polypeptide binding]; other site 443149010931 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 443149010932 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 443149010933 active site 443149010934 FMN binding site [chemical binding]; other site 443149010935 substrate binding site [chemical binding]; other site 443149010936 3Fe-4S cluster binding site [ion binding]; other site 443149010937 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 443149010938 domain interface; other site 443149010939 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 443149010940 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 443149010941 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 443149010942 EspG family; Region: ESX-1_EspG; pfam14011 443149010943 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 443149010944 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443149010945 Walker A motif; other site 443149010946 ATP binding site [chemical binding]; other site 443149010947 Walker B motif; other site 443149010948 arginine finger; other site 443149010949 Protein of unknown function (DUF690); Region: DUF690; pfam05108 443149010950 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 443149010951 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 443149010952 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 443149010953 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 443149010954 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 443149010955 PE family; Region: PE; pfam00934 443149010956 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149010957 PPE family; Region: PPE; pfam00823 443149010958 Proteins of 100 residues with WXG; Region: WXG100; cl02005 443149010959 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 443149010960 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 443149010961 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 443149010962 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 443149010963 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 443149010964 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 443149010965 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 443149010966 active site 443149010967 catalytic residues [active] 443149010968 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 443149010969 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443149010970 Walker A motif; other site 443149010971 ATP binding site [chemical binding]; other site 443149010972 Walker B motif; other site 443149010973 arginine finger; other site 443149010974 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 443149010975 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 443149010976 catalytic residues [active] 443149010977 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 443149010978 active site 443149010979 catalytic residues [active] 443149010980 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 443149010981 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 443149010982 EspG family; Region: ESX-1_EspG; pfam14011 443149010983 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 443149010984 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 443149010985 PPE family; Region: PPE; pfam00823 443149010986 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 443149010987 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 443149010988 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 443149010989 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 443149010990 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 443149010991 Protein of unknown function (DUF690); Region: DUF690; pfam05108 443149010992 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 443149010993 N-acetyl-D-glucosamine binding site [chemical binding]; other site 443149010994 catalytic residue [active] 443149010995 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 443149010996 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 443149010997 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 443149010998 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 443149010999 active site 443149011000 NTP binding site [chemical binding]; other site 443149011001 metal binding triad [ion binding]; metal-binding site 443149011002 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 443149011003 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443149011004 Zn2+ binding site [ion binding]; other site 443149011005 Mg2+ binding site [ion binding]; other site 443149011006 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 443149011007 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 443149011008 active site 443149011009 Ap6A binding site [chemical binding]; other site 443149011010 nudix motif; other site 443149011011 metal binding site [ion binding]; metal-binding site 443149011012 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 443149011013 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 443149011014 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 443149011015 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443149011016 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443149011017 DNA binding residues [nucleotide binding] 443149011018 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 443149011019 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 443149011020 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443149011021 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 443149011022 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 443149011023 catalytic residues [active] 443149011024 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 443149011025 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 443149011026 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 443149011027 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 443149011028 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 443149011029 active site 443149011030 metal binding site [ion binding]; metal-binding site 443149011031 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 443149011032 ParB-like nuclease domain; Region: ParB; smart00470 443149011033 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 443149011034 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 443149011035 P-loop; other site 443149011036 Magnesium ion binding site [ion binding]; other site 443149011037 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 443149011038 Magnesium ion binding site [ion binding]; other site 443149011039 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 443149011040 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 443149011041 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 443149011042 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 443149011043 G-X-X-G motif; other site 443149011044 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 443149011045 RxxxH motif; other site 443149011046 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 443149011047 Uncharacterized conserved protein [Function unknown]; Region: COG0759 443149011048 ribonuclease P; Reviewed; Region: rnpA; PRK00588 443149011049 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399