-- dump date 20140619_154102 -- class Genbank::misc_feature -- table misc_feature_note -- id note 443150000001 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 443150000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443150000003 Walker A motif; other site 443150000004 ATP binding site [chemical binding]; other site 443150000005 Walker B motif; other site 443150000006 arginine finger; other site 443150000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 443150000008 DnaA box-binding interface [nucleotide binding]; other site 443150000009 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 443150000010 Transposase; Region: HTH_Tnp_1; cl17663 443150000011 putative transposase OrfB; Reviewed; Region: PHA02517 443150000012 HTH-like domain; Region: HTH_21; pfam13276 443150000013 Integrase core domain; Region: rve; pfam00665 443150000014 Integrase core domain; Region: rve_3; pfam13683 443150000015 DNA polymerase III subunit beta; Validated; Region: PRK07761 443150000016 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 443150000017 putative DNA binding surface [nucleotide binding]; other site 443150000018 dimer interface [polypeptide binding]; other site 443150000019 beta-clamp/clamp loader binding surface; other site 443150000020 beta-clamp/translesion DNA polymerase binding surface; other site 443150000021 recF protein; Region: recf; TIGR00611 443150000022 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 443150000023 Walker A/P-loop; other site 443150000024 ATP binding site [chemical binding]; other site 443150000025 Q-loop/lid; other site 443150000026 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443150000027 ABC transporter signature motif; other site 443150000028 Walker B; other site 443150000029 D-loop; other site 443150000030 H-loop/switch region; other site 443150000031 hypothetical protein; Provisional; Region: PRK03195 443150000032 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 443150000033 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443150000034 Mg2+ binding site [ion binding]; other site 443150000035 G-X-G motif; other site 443150000036 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 443150000037 anchoring element; other site 443150000038 dimer interface [polypeptide binding]; other site 443150000039 ATP binding site [chemical binding]; other site 443150000040 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 443150000041 active site 443150000042 putative metal-binding site [ion binding]; other site 443150000043 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 443150000044 DNA gyrase subunit A; Validated; Region: PRK05560 443150000045 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 443150000046 CAP-like domain; other site 443150000047 active site 443150000048 primary dimer interface [polypeptide binding]; other site 443150000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 443150000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 443150000051 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 443150000052 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 443150000053 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 443150000054 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 443150000055 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 443150000056 Protein of unknown function (DUF2562); Region: DUF2562; pfam10814 443150000057 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 443150000058 active site 443150000059 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 443150000060 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 443150000061 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 443150000062 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 443150000063 Glutamine amidotransferase class-I; Region: GATase; pfam00117 443150000064 glutamine binding [chemical binding]; other site 443150000065 catalytic triad [active] 443150000066 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 443150000067 Catalytic domain of Protein Kinases; Region: PKc; cd00180 443150000068 active site 443150000069 ATP binding site [chemical binding]; other site 443150000070 substrate binding site [chemical binding]; other site 443150000071 activation loop (A-loop); other site 443150000072 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 443150000073 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 443150000074 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 443150000075 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 443150000076 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 443150000077 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 443150000078 Catalytic domain of Protein Kinases; Region: PKc; cd00180 443150000079 active site 443150000080 ATP binding site [chemical binding]; other site 443150000081 substrate binding site [chemical binding]; other site 443150000082 activation loop (A-loop); other site 443150000083 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 443150000084 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 443150000085 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 443150000086 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 443150000087 active site 443150000088 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 443150000089 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 443150000090 phosphopeptide binding site; other site 443150000091 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 443150000092 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 443150000093 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 443150000094 phosphopeptide binding site; other site 443150000095 Nitronate monooxygenase; Region: NMO; pfam03060 443150000096 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 443150000097 FMN binding site [chemical binding]; other site 443150000098 substrate binding site [chemical binding]; other site 443150000099 putative catalytic residue [active] 443150000100 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 443150000101 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443150000102 non-specific DNA binding site [nucleotide binding]; other site 443150000103 salt bridge; other site 443150000104 sequence-specific DNA binding site [nucleotide binding]; other site 443150000105 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 443150000106 NlpC/P60 family; Region: NLPC_P60; pfam00877 443150000107 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 443150000108 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 443150000109 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 443150000110 Protein of unknown function (DUF2694); Region: DUF2694; pfam10904 443150000111 Protein of unknown function (DUF2710); Region: DUF2710; pfam10921 443150000112 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 443150000113 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 443150000114 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 443150000115 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443150000116 catalytic residue [active] 443150000117 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 443150000118 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 443150000119 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 443150000120 acyl-activating enzyme (AAE) consensus motif; other site 443150000121 active site 443150000122 TIGR03084 family protein; Region: TIGR03084 443150000123 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 443150000124 Wyosine base formation; Region: Wyosine_form; pfam08608 443150000125 H+ Antiporter protein; Region: 2A0121; TIGR00900 443150000126 hypothetical protein; Validated; Region: PRK00228 443150000127 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 443150000128 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 443150000129 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 443150000130 active site 443150000131 HIGH motif; other site 443150000132 nucleotide binding site [chemical binding]; other site 443150000133 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 443150000134 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 443150000135 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 443150000136 active site 443150000137 KMSKS motif; other site 443150000138 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 443150000139 tRNA binding surface [nucleotide binding]; other site 443150000140 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 443150000141 MarR family; Region: MarR; pfam01047 443150000142 Transcriptional regulators [Transcription]; Region: FadR; COG2186 443150000143 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443150000144 DNA-binding site [nucleotide binding]; DNA binding site 443150000145 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 443150000146 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 443150000147 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 443150000148 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 443150000149 inositol 1-phosphate synthase, Actinobacterial type; Region: mycothiol_INO1; TIGR03450 443150000150 Predicted transcriptional regulators [Transcription]; Region: COG1695 443150000151 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 443150000152 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 443150000153 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 443150000154 Transglycosylase; Region: Transgly; pfam00912 443150000155 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 443150000156 Predicted integral membrane protein [Function unknown]; Region: COG5650 443150000157 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 443150000158 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 443150000159 conserved cys residue [active] 443150000160 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 443150000161 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 443150000162 dimer interface [polypeptide binding]; other site 443150000163 ssDNA binding site [nucleotide binding]; other site 443150000164 tetramer (dimer of dimers) interface [polypeptide binding]; other site 443150000165 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 443150000166 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 443150000167 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 443150000168 replicative DNA helicase; Validated; Region: PRK07773 443150000169 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 443150000170 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 443150000171 Walker A motif; other site 443150000172 ATP binding site [chemical binding]; other site 443150000173 Walker B motif; other site 443150000174 DNA binding loops [nucleotide binding] 443150000175 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 443150000176 protein-splicing catalytic site; other site 443150000177 thioester formation/cholesterol transfer; other site 443150000178 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 443150000179 protein-splicing catalytic site; other site 443150000180 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 443150000181 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 443150000182 ADP-ribose binding site [chemical binding]; other site 443150000183 Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1 [General function prediction only]; Region: COG2110 443150000184 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 443150000185 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 443150000186 FAD binding domain; Region: FAD_binding_4; pfam01565 443150000187 Berberine and berberine like; Region: BBE; pfam08031 443150000188 hypothetical protein; Provisional; Region: PRK12438 443150000189 hypothetical protein; Validated; Region: PRK00068 443150000190 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 443150000191 homotetrameric interface [polypeptide binding]; other site 443150000192 putative active site [active] 443150000193 metal binding site [ion binding]; metal-binding site 443150000194 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 443150000195 Monomeric isocitrate dehydrogenase; Region: IDH; pfam03971 443150000196 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443150000197 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443150000198 short chain dehydrogenase; Provisional; Region: PRK06197 443150000199 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 443150000200 putative NAD(P) binding site [chemical binding]; other site 443150000201 active site 443150000202 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 443150000203 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 443150000204 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 443150000205 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 443150000206 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 443150000207 dimer interface [polypeptide binding]; other site 443150000208 active site 443150000209 glycine-pyridoxal phosphate binding site [chemical binding]; other site 443150000210 folate binding site [chemical binding]; other site 443150000211 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 443150000212 active site 443150000213 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 443150000214 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443150000215 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443150000216 homodimer interface [polypeptide binding]; other site 443150000217 catalytic residue [active] 443150000218 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443150000219 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443150000220 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443150000221 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 443150000222 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443150000223 dimerization interface [polypeptide binding]; other site 443150000224 putative DNA binding site [nucleotide binding]; other site 443150000225 putative Zn2+ binding site [ion binding]; other site 443150000226 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 443150000227 hydrogenase 4 subunit B; Validated; Region: PRK06521 443150000228 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 443150000229 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 443150000230 NADH dehydrogenase; Region: NADHdh; cl00469 443150000231 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; COG4237 443150000232 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 443150000233 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 443150000234 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 443150000235 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 443150000236 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 443150000237 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 443150000238 putative hydrophobic ligand binding site [chemical binding]; other site 443150000239 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443150000240 S-adenosylmethionine binding site [chemical binding]; other site 443150000241 Predicted membrane protein [Function unknown]; Region: COG3305 443150000242 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 443150000243 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 443150000244 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 443150000245 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 443150000246 Soluble P-type ATPase [General function prediction only]; Region: COG4087 443150000247 Domain of unknown function (DUF222); Region: DUF222; pfam02720 443150000248 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 443150000249 active site 443150000250 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150000251 PPE family; Region: PPE; pfam00823 443150000252 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 443150000253 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 443150000254 FcoT-like thioesterase domain; Region: FcoT; pfam10862 443150000255 acyl-CoA synthetase; Validated; Region: PRK05857 443150000256 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443150000257 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 443150000258 acyl-activating enzyme (AAE) consensus motif; other site 443150000259 acyl-activating enzyme (AAE) consensus motif; other site 443150000260 AMP binding site [chemical binding]; other site 443150000261 active site 443150000262 CoA binding site [chemical binding]; other site 443150000263 AMP-binding enzyme; Region: AMP-binding; pfam00501 443150000264 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443150000265 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443150000266 acyl-activating enzyme (AAE) consensus motif; other site 443150000267 acyl-activating enzyme (AAE) consensus motif; other site 443150000268 active site 443150000269 AMP binding site [chemical binding]; other site 443150000270 CoA binding site [chemical binding]; other site 443150000271 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 443150000272 Condensation domain; Region: Condensation; pfam00668 443150000273 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 443150000274 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 443150000275 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 443150000276 acyl-activating enzyme (AAE) consensus motif; other site 443150000277 AMP binding site [chemical binding]; other site 443150000278 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 443150000279 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 443150000280 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 443150000281 putative NAD(P) binding site [chemical binding]; other site 443150000282 active site 443150000283 putative substrate binding site [chemical binding]; other site 443150000284 Predicted membrane protein [Function unknown]; Region: COG3336 443150000285 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 443150000286 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 443150000287 metal-binding site [ion binding] 443150000288 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 443150000289 Soluble P-type ATPase [General function prediction only]; Region: COG4087 443150000290 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 443150000291 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 443150000292 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 443150000293 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 443150000294 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 443150000295 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 443150000296 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443150000297 motif II; other site 443150000298 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 443150000299 PE family; Region: PE; pfam00934 443150000300 Rhomboid family; Region: Rhomboid; pfam01694 443150000301 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 443150000302 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 443150000303 active site 443150000304 catalytic triad [active] 443150000305 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 443150000306 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 443150000307 NADP-binding site; other site 443150000308 homotetramer interface [polypeptide binding]; other site 443150000309 substrate binding site [chemical binding]; other site 443150000310 homodimer interface [polypeptide binding]; other site 443150000311 active site 443150000312 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 443150000313 dimer interface [polypeptide binding]; other site 443150000314 active site 443150000315 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 443150000316 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 443150000317 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 443150000318 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 443150000319 Transcriptional regulator [Transcription]; Region: LysR; COG0583 443150000320 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 443150000321 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 443150000322 dimerization interface [polypeptide binding]; other site 443150000323 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 443150000324 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 443150000325 PYR/PP interface [polypeptide binding]; other site 443150000326 dimer interface [polypeptide binding]; other site 443150000327 TPP binding site [chemical binding]; other site 443150000328 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 443150000329 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 443150000330 TPP-binding site; other site 443150000331 dimer interface [polypeptide binding]; other site 443150000332 acyl-CoA synthetase; Validated; Region: PRK05852 443150000333 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443150000334 Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926 443150000335 acyl-activating enzyme (AAE) consensus motif; other site 443150000336 acyl-activating enzyme (AAE) consensus motif; other site 443150000337 putative AMP binding site [chemical binding]; other site 443150000338 putative active site [active] 443150000339 putative CoA binding site [chemical binding]; other site 443150000340 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 443150000341 elongation factor G; Reviewed; Region: PRK12740 443150000342 G1 box; other site 443150000343 putative GEF interaction site [polypeptide binding]; other site 443150000344 GTP/Mg2+ binding site [chemical binding]; other site 443150000345 Switch I region; other site 443150000346 G2 box; other site 443150000347 G3 box; other site 443150000348 Switch II region; other site 443150000349 G4 box; other site 443150000350 G5 box; other site 443150000351 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 443150000352 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 443150000353 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 443150000354 PPOX class probable F420-dependent enzyme, Rv0121 family; Region: Rv0121_F420; TIGR03668 443150000355 PE family; Region: PE; pfam00934 443150000356 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 443150000357 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 443150000358 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 443150000359 trehalose synthase; Region: treS_nterm; TIGR02456 443150000360 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 443150000361 active site 443150000362 catalytic site [active] 443150000363 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 443150000364 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 443150000365 Predicted membrane protein [Function unknown]; Region: COG3619 443150000366 Predicted esterase [General function prediction only]; Region: COG0627 443150000367 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 443150000368 putative active site [active] 443150000369 putative catalytic site [active] 443150000370 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443150000371 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443150000372 active site 443150000373 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 443150000374 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 443150000375 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 443150000376 Coenzyme A binding pocket [chemical binding]; other site 443150000377 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 443150000378 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443150000379 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443150000380 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443150000381 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443150000382 Cytochrome P450; Region: p450; cl12078 443150000383 methionine sulfoxide reductase A; Provisional; Region: PRK14054 443150000384 SnoaL-like domain; Region: SnoaL_2; pfam12680 443150000385 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 443150000386 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443150000387 NAD(P) binding site [chemical binding]; other site 443150000388 active site 443150000389 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 443150000390 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 443150000391 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 443150000392 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 443150000393 minor groove reading motif; other site 443150000394 helix-hairpin-helix signature motif; other site 443150000395 active site 443150000396 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 443150000397 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 443150000398 Cl- selectivity filter; other site 443150000399 Cl- binding residues [ion binding]; other site 443150000400 pore gating glutamate residue; other site 443150000401 dimer interface [polypeptide binding]; other site 443150000402 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443150000403 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443150000404 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 443150000405 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 443150000406 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 443150000407 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 443150000408 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 443150000409 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 443150000410 NAD(P) binding site [chemical binding]; other site 443150000411 catalytic residues [active] 443150000412 short chain dehydrogenase; Provisional; Region: PRK07791 443150000413 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 443150000414 NAD binding site [chemical binding]; other site 443150000415 homodimer interface [polypeptide binding]; other site 443150000416 active site 443150000417 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 443150000418 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 443150000419 NAD(P) binding site [chemical binding]; other site 443150000420 PE family; Region: PE; pfam00934 443150000421 PE-PPE domain; Region: PE-PPE; pfam08237 443150000422 PE-PPE domain; Region: PE-PPE; pfam08237 443150000423 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 443150000424 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 443150000425 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 443150000426 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443150000427 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 443150000428 FAD binding site [chemical binding]; other site 443150000429 substrate binding site [chemical binding]; other site 443150000430 catalytic base [active] 443150000431 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 443150000432 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 443150000433 ligand binding site [chemical binding]; other site 443150000434 homodimer interface [polypeptide binding]; other site 443150000435 NAD(P) binding site [chemical binding]; other site 443150000436 trimer interface B [polypeptide binding]; other site 443150000437 trimer interface A [polypeptide binding]; other site 443150000438 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 443150000439 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 443150000440 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 443150000441 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 443150000442 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443150000443 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443150000444 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 443150000445 PE family; Region: PE; pfam00934 443150000446 PE-PPE domain; Region: PE-PPE; pfam08237 443150000447 PE family; Region: PE; pfam00934 443150000448 PE-PPE domain; Region: PE-PPE; pfam08237 443150000449 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 443150000450 FAD binding domain; Region: FAD_binding_4; pfam01565 443150000451 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 443150000452 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 443150000453 NAD(P) binding site [chemical binding]; other site 443150000454 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 443150000455 active site 443150000456 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 443150000457 putative hydrophobic ligand binding site [chemical binding]; other site 443150000458 Transcriptional regulators [Transcription]; Region: GntR; COG1802 443150000459 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443150000460 DNA-binding site [nucleotide binding]; DNA binding site 443150000461 FCD domain; Region: FCD; pfam07729 443150000462 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786 443150000463 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443150000464 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 443150000465 acyl-activating enzyme (AAE) consensus motif; other site 443150000466 acyl-activating enzyme (AAE) consensus motif; other site 443150000467 putative AMP binding site [chemical binding]; other site 443150000468 putative active site [active] 443150000469 putative CoA binding site [chemical binding]; other site 443150000470 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 443150000471 Permease; Region: Permease; pfam02405 443150000472 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 443150000473 Permease; Region: Permease; pfam02405 443150000474 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443150000475 mce related protein; Region: MCE; pfam02470 443150000476 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 443150000477 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443150000478 mce related protein; Region: MCE; pfam02470 443150000479 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 443150000480 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443150000481 mce related protein; Region: MCE; pfam02470 443150000482 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443150000483 mce related protein; Region: MCE; pfam02470 443150000484 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443150000485 mce related protein; Region: MCE; pfam02470 443150000486 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443150000487 mce related protein; Region: MCE; pfam02470 443150000488 RDD family; Region: RDD; pfam06271 443150000489 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 443150000490 Predicted membrane protein [Function unknown]; Region: COG1511 443150000491 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 443150000492 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 443150000493 Pirin-related protein [General function prediction only]; Region: COG1741 443150000494 Pirin; Region: Pirin; pfam02678 443150000495 RNA polymerase factor sigma-70; Validated; Region: PRK08241 443150000496 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443150000497 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443150000498 DNA binding residues [nucleotide binding] 443150000499 SnoaL-like domain; Region: SnoaL_2; pfam12680 443150000500 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 443150000501 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 443150000502 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 443150000503 putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185 443150000504 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 443150000505 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 443150000506 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 443150000507 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 443150000508 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 443150000509 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443150000510 S-adenosylmethionine binding site [chemical binding]; other site 443150000511 SPW repeat; Region: SPW; pfam03779 443150000512 SPW repeat; Region: SPW; pfam03779 443150000513 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 443150000514 6-phosphogluconate dehydratase; Region: edd; TIGR01196 443150000515 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443150000516 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 443150000517 putative substrate translocation pore; other site 443150000518 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 443150000519 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 443150000520 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 443150000521 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 443150000522 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 443150000523 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443150000524 Walker A/P-loop; other site 443150000525 ATP binding site [chemical binding]; other site 443150000526 Q-loop/lid; other site 443150000527 ABC transporter signature motif; other site 443150000528 Walker B; other site 443150000529 D-loop; other site 443150000530 H-loop/switch region; other site 443150000531 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 443150000532 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443150000533 Walker A/P-loop; other site 443150000534 ATP binding site [chemical binding]; other site 443150000535 Q-loop/lid; other site 443150000536 ABC transporter signature motif; other site 443150000537 Walker B; other site 443150000538 D-loop; other site 443150000539 H-loop/switch region; other site 443150000540 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443150000541 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443150000542 dimerization interface [polypeptide binding]; other site 443150000543 DNA binding residues [nucleotide binding] 443150000544 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443150000545 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443150000546 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 443150000547 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 443150000548 putative [Fe4-S4] binding site [ion binding]; other site 443150000549 putative molybdopterin cofactor binding site [chemical binding]; other site 443150000550 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 443150000551 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 443150000552 putative molybdopterin cofactor binding site; other site 443150000553 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 443150000554 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 443150000555 active site 443150000556 Zn binding site [ion binding]; other site 443150000557 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 443150000558 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 443150000559 Predicted integral membrane protein [Function unknown]; Region: COG0392 443150000560 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 443150000561 Domain of unknown function DUF20; Region: UPF0118; pfam01594 443150000562 MMPL family; Region: MMPL; pfam03176 443150000563 MMPL family; Region: MMPL; pfam03176 443150000564 LabA_like proteins; Region: LabA_like; cd06167 443150000565 putative metal binding site [ion binding]; other site 443150000566 Putative methyltransferase; Region: Methyltransf_4; pfam02390 443150000567 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 443150000568 active site 443150000569 substrate-binding site [chemical binding]; other site 443150000570 metal-binding site [ion binding] 443150000571 GTP binding site [chemical binding]; other site 443150000572 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 443150000573 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 443150000574 active site 443150000575 (T/H)XGH motif; other site 443150000576 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 443150000577 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 443150000578 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 443150000579 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443150000580 FeS/SAM binding site; other site 443150000581 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 443150000582 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443150000583 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 443150000584 acyl-activating enzyme (AAE) consensus motif; other site 443150000585 acyl-activating enzyme (AAE) consensus motif; other site 443150000586 putative AMP binding site [chemical binding]; other site 443150000587 putative active site [active] 443150000588 putative CoA binding site [chemical binding]; other site 443150000589 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443150000590 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443150000591 active site 443150000592 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 443150000593 putative active site [active] 443150000594 putative catalytic site [active] 443150000595 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 443150000596 active site 2 [active] 443150000597 active site 1 [active] 443150000598 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 443150000599 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 443150000600 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 443150000601 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321 443150000602 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 443150000603 Moco binding site; other site 443150000604 metal coordination site [ion binding]; other site 443150000605 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 443150000606 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 443150000607 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443150000608 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443150000609 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 443150000610 enoyl-CoA hydratase; Provisional; Region: PRK08252 443150000611 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443150000612 substrate binding site [chemical binding]; other site 443150000613 oxyanion hole (OAH) forming residues; other site 443150000614 trimer interface [polypeptide binding]; other site 443150000615 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 443150000616 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 443150000617 NAD binding site [chemical binding]; other site 443150000618 catalytic residues [active] 443150000619 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443150000620 S-adenosylmethionine binding site [chemical binding]; other site 443150000621 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 443150000622 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443150000623 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 443150000624 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 443150000625 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 443150000626 putative active site [active] 443150000627 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 443150000628 active site 443150000629 substrate binding pocket [chemical binding]; other site 443150000630 homodimer interaction site [polypeptide binding]; other site 443150000631 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443150000632 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 443150000633 active site 443150000634 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443150000635 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443150000636 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 443150000637 active site 443150000638 diiron metal binding site [ion binding]; other site 443150000639 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 443150000640 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 443150000641 NAD(P) binding site [chemical binding]; other site 443150000642 catalytic residues [active] 443150000643 Lipase maturation factor; Region: LMF1; pfam06762 443150000644 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 443150000645 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 443150000646 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 443150000647 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443150000648 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443150000649 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 443150000650 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 443150000651 MaoC like domain; Region: MaoC_dehydratas; pfam01575 443150000652 active site 2 [active] 443150000653 active site 1 [active] 443150000654 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 443150000655 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443150000656 NAD(P) binding site [chemical binding]; other site 443150000657 active site 443150000658 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 443150000659 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 443150000660 dimer interface [polypeptide binding]; other site 443150000661 active site 443150000662 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 443150000663 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 443150000664 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 443150000665 FAD binding site [chemical binding]; other site 443150000666 substrate binding site [chemical binding]; other site 443150000667 catalytic residues [active] 443150000668 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 443150000669 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 443150000670 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 443150000671 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443150000672 catalytic loop [active] 443150000673 iron binding site [ion binding]; other site 443150000674 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 443150000675 L-aspartate oxidase; Provisional; Region: PRK06175 443150000676 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 443150000677 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 443150000678 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 443150000679 putative dimer interface [polypeptide binding]; other site 443150000680 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 443150000681 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443150000682 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 443150000683 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 443150000684 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 443150000685 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 443150000686 homotrimer interface [polypeptide binding]; other site 443150000687 Walker A motif; other site 443150000688 GTP binding site [chemical binding]; other site 443150000689 Walker B motif; other site 443150000690 cobyric acid synthase; Provisional; Region: PRK00784 443150000691 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 443150000692 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 443150000693 catalytic triad [active] 443150000694 potential frameshift: common BLAST hit: gi|378770002|ref|YP_005169735.1| PPE family protein 443150000695 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150000696 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150000697 PPE family; Region: PPE; pfam00823 443150000698 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 443150000699 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 443150000700 putative active site [active] 443150000701 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 443150000702 putative active site [active] 443150000703 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 443150000704 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 443150000705 active site 443150000706 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 443150000707 DNA binding site [nucleotide binding] 443150000708 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 443150000709 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443150000710 Coenzyme A binding pocket [chemical binding]; other site 443150000711 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 443150000712 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 443150000713 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 443150000714 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 443150000715 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 443150000716 intersubunit interface [polypeptide binding]; other site 443150000717 5-oxoprolinase; Region: PLN02666 443150000718 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 443150000719 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 443150000720 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 443150000721 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 443150000722 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 443150000723 nucleotide binding site [chemical binding]; other site 443150000724 acyl-CoA synthetase; Validated; Region: PRK07788 443150000725 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443150000726 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443150000727 active site 443150000728 CoA binding site [chemical binding]; other site 443150000729 AMP binding site [chemical binding]; other site 443150000730 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443150000731 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443150000732 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 443150000733 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443150000734 FAD binding site [chemical binding]; other site 443150000735 substrate binding site [chemical binding]; other site 443150000736 catalytic base [active] 443150000737 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443150000738 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443150000739 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443150000740 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 443150000741 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 443150000742 putative active site [active] 443150000743 PE family; Region: PE; pfam00934 443150000744 PE family; Region: PE; pfam00934 443150000745 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150000746 PPE family; Region: PPE; pfam00823 443150000747 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150000748 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 443150000749 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 443150000750 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 443150000751 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443150000752 Walker A motif; other site 443150000753 ATP binding site [chemical binding]; other site 443150000754 Walker B motif; other site 443150000755 arginine finger; other site 443150000756 Protein of unknown function (DUF690); Region: DUF690; pfam05108 443150000757 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 443150000758 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 443150000759 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 443150000760 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 443150000761 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 443150000762 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150000763 PPE family; Region: PPE; pfam00823 443150000764 EspG family; Region: ESX-1_EspG; pfam14011 443150000765 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 443150000766 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 443150000767 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 443150000768 active site 443150000769 catalytic residues [active] 443150000770 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 443150000771 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443150000772 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 443150000773 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 443150000774 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443150000775 S-adenosylmethionine binding site [chemical binding]; other site 443150000776 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4424 443150000777 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 443150000778 Sulfatase; Region: Sulfatase; cl17466 443150000779 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 443150000780 putative active site [active] 443150000781 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443150000782 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443150000783 light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs; Region: LPOR_like_SDR_c_like; cd09810 443150000784 protochlorophyllide reductase; Region: PLN00015 443150000785 putative NAD(P) binding site [chemical binding]; other site 443150000786 active site 443150000787 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150000788 PPE family; Region: PPE; pfam00823 443150000789 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150000790 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443150000791 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150000792 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443150000793 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443150000794 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150000795 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443150000796 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443150000797 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150000798 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443150000799 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443150000800 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443150000801 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 443150000802 putative FMN binding site [chemical binding]; other site 443150000803 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 443150000804 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 443150000805 active site 443150000806 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 443150000807 SnoaL-like domain; Region: SnoaL_4; pfam13577 443150000808 SnoaL-like domain; Region: SnoaL_3; pfam13474 443150000809 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 443150000810 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 443150000811 nucleotide binding site [chemical binding]; other site 443150000812 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]; Region: HtpG; COG0326 443150000813 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 443150000814 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 443150000815 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 443150000816 active site 443150000817 catalytic residues [active] 443150000818 Muconolactone delta-isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CatC1; COG4829 443150000819 Muconolactone delta-isomerase; Region: MIase; cl01992 443150000820 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 443150000821 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 443150000822 putative active site [active] 443150000823 putative metal binding site [ion binding]; other site 443150000824 catalytic site [active] 443150000825 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 443150000826 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 443150000827 putative substrate binding pocket [chemical binding]; other site 443150000828 AC domain interface; other site 443150000829 catalytic triad [active] 443150000830 AB domain interface; other site 443150000831 interchain disulfide; other site 443150000832 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 443150000833 trimer interface [polypeptide binding]; other site 443150000834 active site 443150000835 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 443150000836 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 443150000837 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 443150000838 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 443150000839 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 443150000840 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443150000841 dimerization interface [polypeptide binding]; other site 443150000842 putative DNA binding site [nucleotide binding]; other site 443150000843 putative Zn2+ binding site [ion binding]; other site 443150000844 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 443150000845 active site residue [active] 443150000846 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443150000847 S-adenosylmethionine binding site [chemical binding]; other site 443150000848 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443150000849 Cytochrome P450; Region: p450; cl12078 443150000850 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 443150000851 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443150000852 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 443150000853 Methyltransferase domain; Region: Methyltransf_23; pfam13489 443150000854 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443150000855 S-adenosylmethionine binding site [chemical binding]; other site 443150000856 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443150000857 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443150000858 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 443150000859 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 443150000860 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 443150000861 SnoaL-like domain; Region: SnoaL_2; pfam12680 443150000862 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 443150000863 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 443150000864 substrate binding site; other site 443150000865 tetramer interface; other site 443150000866 PE family; Region: PE; pfam00934 443150000867 Domain of unknown function (DUF222); Region: DUF222; pfam02720 443150000868 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 443150000869 active site 443150000870 aminotransferase AlaT; Validated; Region: PRK09265 443150000871 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443150000872 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443150000873 homodimer interface [polypeptide binding]; other site 443150000874 catalytic residue [active] 443150000875 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 443150000876 4Fe-4S binding domain; Region: Fer4; pfam00037 443150000877 Cysteine-rich domain; Region: CCG; pfam02754 443150000878 Cysteine-rich domain; Region: CCG; pfam02754 443150000879 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443150000880 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443150000881 DNA binding residues [nucleotide binding] 443150000882 dimerization interface [polypeptide binding]; other site 443150000883 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 443150000884 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 443150000885 G1 box; other site 443150000886 GTP/Mg2+ binding site [chemical binding]; other site 443150000887 G2 box; other site 443150000888 Switch I region; other site 443150000889 G3 box; other site 443150000890 Switch II region; other site 443150000891 G4 box; other site 443150000892 G5 box; other site 443150000893 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 443150000894 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 443150000895 G1 box; other site 443150000896 GTP/Mg2+ binding site [chemical binding]; other site 443150000897 G2 box; other site 443150000898 Switch I region; other site 443150000899 G3 box; other site 443150000900 Switch II region; other site 443150000901 Uncharacterized MobA-related protein [General function prediction only]; Region: COG2068 443150000902 active site 443150000903 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 443150000904 TIGR04255 family protein; Region: sporadTIGR04255 443150000905 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 443150000906 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 443150000907 nucleotide binding site [chemical binding]; other site 443150000908 NEF interaction site [polypeptide binding]; other site 443150000909 SBD interface [polypeptide binding]; other site 443150000910 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 443150000911 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 443150000912 dimer interface [polypeptide binding]; other site 443150000913 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 443150000914 chaperone protein DnaJ; Provisional; Region: PRK14279 443150000915 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 443150000916 HSP70 interaction site [polypeptide binding]; other site 443150000917 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 443150000918 Zn binding sites [ion binding]; other site 443150000919 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 443150000920 dimer interface [polypeptide binding]; other site 443150000921 Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279 443150000922 DNA binding residues [nucleotide binding] 443150000923 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 443150000924 putative dimer interface [polypeptide binding]; other site 443150000925 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150000926 PPE family; Region: PPE; pfam00823 443150000927 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443150000928 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150000929 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150000930 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150000931 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 443150000932 CoenzymeA binding site [chemical binding]; other site 443150000933 subunit interaction site [polypeptide binding]; other site 443150000934 PHB binding site; other site 443150000935 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 443150000936 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 443150000937 GDP-binding site [chemical binding]; other site 443150000938 ACT binding site; other site 443150000939 IMP binding site; other site 443150000940 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 443150000941 Peptidase family M50; Region: Peptidase_M50; pfam02163 443150000942 active site 443150000943 putative substrate binding region [chemical binding]; other site 443150000944 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 443150000945 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 443150000946 MgtE intracellular N domain; Region: MgtE_N; pfam03448 443150000947 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 443150000948 Divalent cation transporter; Region: MgtE; pfam01769 443150000949 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 443150000950 fructose-bisphosphate aldolase, class II, yeast/E. coli subtype; Region: FruBisAldo_II_A; TIGR01520 443150000951 active site 443150000952 intersubunit interface [polypeptide binding]; other site 443150000953 zinc binding site [ion binding]; other site 443150000954 Na+ binding site [ion binding]; other site 443150000955 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 443150000956 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 443150000957 Predicted glycosyl hydrolase [Carbohydrate transport and metabolism]; Region: COG4833 443150000958 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 443150000959 AAA domain; Region: AAA_33; pfam13671 443150000960 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 443150000961 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 443150000962 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 443150000963 metal ion-dependent adhesion site (MIDAS); other site 443150000964 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 443150000965 putative hydrophobic ligand binding site [chemical binding]; other site 443150000966 MoxR-like ATPases [General function prediction only]; Region: COG0714 443150000967 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 443150000968 Ligand binding site; other site 443150000969 metal-binding site 443150000970 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 443150000971 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 443150000972 XdhC Rossmann domain; Region: XdhC_C; pfam13478 443150000973 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 443150000974 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 443150000975 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 443150000976 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 443150000977 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443150000978 catalytic loop [active] 443150000979 iron binding site [ion binding]; other site 443150000980 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 443150000981 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 443150000982 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 443150000983 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 443150000984 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 443150000985 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 443150000986 XdhC Rossmann domain; Region: XdhC_C; pfam13478 443150000987 Transcriptional regulator [Transcription]; Region: LysR; COG0583 443150000988 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 443150000989 LysR substrate binding domain; Region: LysR_substrate; pfam03466 443150000990 dimerization interface [polypeptide binding]; other site 443150000991 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 443150000992 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 443150000993 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 443150000994 active site 443150000995 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 443150000996 Clp amino terminal domain; Region: Clp_N; pfam02861 443150000997 Clp amino terminal domain; Region: Clp_N; pfam02861 443150000998 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443150000999 Walker A motif; other site 443150001000 ATP binding site [chemical binding]; other site 443150001001 Walker B motif; other site 443150001002 arginine finger; other site 443150001003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443150001004 Walker A motif; other site 443150001005 ATP binding site [chemical binding]; other site 443150001006 Walker B motif; other site 443150001007 arginine finger; other site 443150001008 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 443150001009 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 443150001010 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 443150001011 heme-binding site [chemical binding]; other site 443150001012 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 443150001013 FAD binding pocket [chemical binding]; other site 443150001014 FAD binding motif [chemical binding]; other site 443150001015 phosphate binding motif [ion binding]; other site 443150001016 beta-alpha-beta structure motif; other site 443150001017 NAD binding pocket [chemical binding]; other site 443150001018 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 443150001019 cyclase homology domain; Region: CHD; cd07302 443150001020 nucleotidyl binding site; other site 443150001021 metal binding site [ion binding]; metal-binding site 443150001022 dimer interface [polypeptide binding]; other site 443150001023 Predicted ATPase [General function prediction only]; Region: COG3903 443150001024 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 443150001025 Walker A motif; other site 443150001026 ATP binding site [chemical binding]; other site 443150001027 Walker B motif; other site 443150001028 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443150001029 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443150001030 DNA binding residues [nucleotide binding] 443150001031 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150001032 PPE family; Region: PPE; pfam00823 443150001033 phosphoribosylglycinamide formyltransferase 2; Region: purT; TIGR01142 443150001034 ATP-grasp domain; Region: ATP-grasp_4; cl17255 443150001035 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 443150001036 active site residue [active] 443150001037 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 443150001038 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 443150001039 homodimer interface [polypeptide binding]; other site 443150001040 substrate-cofactor binding pocket; other site 443150001041 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443150001042 catalytic residue [active] 443150001043 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 443150001044 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 443150001045 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443150001046 Domain of unknown function (DUF222); Region: DUF222; pfam02720 443150001047 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 443150001048 active site 443150001049 PLD-like domain; Region: PLDc_2; pfam13091 443150001050 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 443150001051 Beta-lactamase; Region: Beta-lactamase; pfam00144 443150001052 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 443150001053 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443150001054 FAD binding site [chemical binding]; other site 443150001055 substrate binding pocket [chemical binding]; other site 443150001056 catalytic base [active] 443150001057 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 443150001058 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 443150001059 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 443150001060 acyl-CoA synthetase; Validated; Region: PRK05850 443150001061 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 443150001062 acyl-activating enzyme (AAE) consensus motif; other site 443150001063 active site 443150001064 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 443150001065 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 443150001066 active site 443150001067 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 443150001068 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 443150001069 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 443150001070 Thioesterase; Region: PKS_TE; smart00824 443150001071 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 443150001072 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 443150001073 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 443150001074 phosphate acetyltransferase; Reviewed; Region: PRK05632 443150001075 DRTGG domain; Region: DRTGG; pfam07085 443150001076 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 443150001077 propionate/acetate kinase; Provisional; Region: PRK12379 443150001078 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 443150001079 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 443150001080 Catalytic domain of Protein Kinases; Region: PKc; cd00180 443150001081 active site 443150001082 ATP binding site [chemical binding]; other site 443150001083 substrate binding site [chemical binding]; other site 443150001084 activation loop (A-loop); other site 443150001085 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 443150001086 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 443150001087 substrate binding pocket [chemical binding]; other site 443150001088 membrane-bound complex binding site; other site 443150001089 hinge residues; other site 443150001090 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 443150001091 nudix motif; other site 443150001092 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 443150001093 thiamine phosphate binding site [chemical binding]; other site 443150001094 active site 443150001095 pyrophosphate binding site [ion binding]; other site 443150001096 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 443150001097 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 443150001098 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 443150001099 ThiS interaction site; other site 443150001100 putative active site [active] 443150001101 tetramer interface [polypeptide binding]; other site 443150001102 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 443150001103 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 443150001104 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 443150001105 PA/protease or protease-like domain interface [polypeptide binding]; other site 443150001106 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 443150001107 active site 443150001108 metal binding site [ion binding]; metal-binding site 443150001109 Predicted metalloprotease [General function prediction only]; Region: COG2321 443150001110 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 443150001111 Zn binding site [ion binding]; other site 443150001112 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 443150001113 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 443150001114 dimer interface [polypeptide binding]; other site 443150001115 substrate binding site [chemical binding]; other site 443150001116 ATP binding site [chemical binding]; other site 443150001117 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 443150001118 ThiC-associated domain; Region: ThiC-associated; pfam13667 443150001119 ThiC family; Region: ThiC; pfam01964 443150001120 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 443150001121 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 443150001122 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443150001123 motif II; other site 443150001124 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 443150001125 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 443150001126 putative catalytic site [active] 443150001127 putative phosphate binding site [ion binding]; other site 443150001128 active site 443150001129 metal binding site A [ion binding]; metal-binding site 443150001130 DNA binding site [nucleotide binding] 443150001131 putative AP binding site [nucleotide binding]; other site 443150001132 putative metal binding site B [ion binding]; other site 443150001133 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 443150001134 active site 443150001135 catalytic residues [active] 443150001136 metal binding site [ion binding]; metal-binding site 443150001137 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 443150001138 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 443150001139 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 443150001140 E-class dimer interface [polypeptide binding]; other site 443150001141 P-class dimer interface [polypeptide binding]; other site 443150001142 active site 443150001143 Cu2+ binding site [ion binding]; other site 443150001144 Zn2+ binding site [ion binding]; other site 443150001145 carboxylate-amine ligase; Provisional; Region: PRK13517 443150001146 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 443150001147 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 443150001148 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 443150001149 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 443150001150 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443150001151 Walker A motif; other site 443150001152 ATP binding site [chemical binding]; other site 443150001153 Walker B motif; other site 443150001154 arginine finger; other site 443150001155 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443150001156 Walker A motif; other site 443150001157 ATP binding site [chemical binding]; other site 443150001158 Walker B motif; other site 443150001159 arginine finger; other site 443150001160 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 443150001161 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 443150001162 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 443150001163 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 443150001164 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 443150001165 dimer interface [polypeptide binding]; other site 443150001166 putative functional site; other site 443150001167 putative MPT binding site; other site 443150001168 short chain dehydrogenase; Provisional; Region: PRK06197 443150001169 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 443150001170 putative NAD(P) binding site [chemical binding]; other site 443150001171 active site 443150001172 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 443150001173 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 443150001174 ring oligomerisation interface [polypeptide binding]; other site 443150001175 ATP/Mg binding site [chemical binding]; other site 443150001176 stacking interactions; other site 443150001177 hinge regions; other site 443150001178 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150001179 PPE family; Region: PPE; pfam00823 443150001180 Protein of unknown function (DUF664); Region: DUF664; pfam04978 443150001181 DinB superfamily; Region: DinB_2; pfam12867 443150001182 putative anti-sigmaE protein; Provisional; Region: PRK13920 443150001183 Anti-sigma-K factor rskA; Region: RskA; pfam10099 443150001184 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 443150001185 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443150001186 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443150001187 DNA binding residues [nucleotide binding] 443150001188 Steroid 5-alpha reductase family enzyme [General function prediction only]; Region: COG3752 443150001189 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 443150001190 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443150001191 S-adenosylmethionine binding site [chemical binding]; other site 443150001192 Uncharacterized conserved protein [Function unknown]; Region: COG3496 443150001193 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 443150001194 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 443150001195 Subunit A of Class III extradiol dioxygenases; Region: Extradiol_Dioxygenase_3A_like; cl06673 443150001196 dimer interface [polypeptide binding]; other site 443150001197 Transport protein; Region: actII; TIGR00833 443150001198 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 443150001199 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443150001200 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150001201 PPE family; Region: PPE; pfam00823 443150001202 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150001203 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 443150001204 enoyl-CoA hydratase; Provisional; Region: PRK12478 443150001205 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443150001206 substrate binding site [chemical binding]; other site 443150001207 oxyanion hole (OAH) forming residues; other site 443150001208 trimer interface [polypeptide binding]; other site 443150001209 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 443150001210 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 443150001211 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 443150001212 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 443150001213 NAD(P) binding site [chemical binding]; other site 443150001214 catalytic residues [active] 443150001215 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3564 443150001216 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 443150001217 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 443150001218 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443150001219 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 443150001220 Uncharacterized conserved protein [Function unknown]; Region: COG2128 443150001221 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 443150001222 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 443150001223 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443150001224 non-specific DNA binding site [nucleotide binding]; other site 443150001225 salt bridge; other site 443150001226 sequence-specific DNA binding site [nucleotide binding]; other site 443150001227 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 443150001228 Domain of unknown function (DUF955); Region: DUF955; pfam06114 443150001229 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 443150001230 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 443150001231 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 443150001232 active site 443150001233 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 443150001234 active site 2 [active] 443150001235 isocitrate lyase; Provisional; Region: PRK15063 443150001236 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cd06556 443150001237 oligomerization interface [polypeptide binding]; other site 443150001238 active site 443150001239 metal binding site [ion binding]; metal-binding site 443150001240 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 443150001241 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 443150001242 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 443150001243 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 443150001244 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443150001245 S-adenosylmethionine binding site [chemical binding]; other site 443150001246 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 443150001247 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 443150001248 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443150001249 S-adenosylmethionine binding site [chemical binding]; other site 443150001250 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443150001251 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443150001252 Predicted membrane protein [Function unknown]; Region: COG2733 443150001253 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 443150001254 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443150001255 non-specific DNA binding site [nucleotide binding]; other site 443150001256 salt bridge; other site 443150001257 sequence-specific DNA binding site [nucleotide binding]; other site 443150001258 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 443150001259 intersubunit interface [polypeptide binding]; other site 443150001260 active site 443150001261 catalytic residue [active] 443150001262 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 443150001263 Predicted amidohydrolase [General function prediction only]; Region: COG0388 443150001264 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 443150001265 putative active site [active] 443150001266 catalytic triad [active] 443150001267 putative dimer interface [polypeptide binding]; other site 443150001268 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 443150001269 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 443150001270 FAD binding domain; Region: FAD_binding_4; pfam01565 443150001271 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 443150001272 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 443150001273 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 443150001274 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 443150001275 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 443150001276 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 443150001277 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443150001278 NAD(P) binding site [chemical binding]; other site 443150001279 active site 443150001280 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 443150001281 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 443150001282 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 443150001283 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 443150001284 putative ADP-binding pocket [chemical binding]; other site 443150001285 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 443150001286 L-lysine exporter; Region: 2a75; TIGR00948 443150001287 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 443150001288 catalytic core [active] 443150001289 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 443150001290 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443150001291 dimer interface [polypeptide binding]; other site 443150001292 phosphorylation site [posttranslational modification] 443150001293 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443150001294 ATP binding site [chemical binding]; other site 443150001295 Mg2+ binding site [ion binding]; other site 443150001296 G-X-G motif; other site 443150001297 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 443150001298 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443150001299 active site 443150001300 phosphorylation site [posttranslational modification] 443150001301 intermolecular recognition site; other site 443150001302 dimerization interface [polypeptide binding]; other site 443150001303 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443150001304 DNA binding site [nucleotide binding] 443150001305 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 443150001306 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 443150001307 Transcriptional regulators [Transcription]; Region: FadR; COG2186 443150001308 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443150001309 DNA-binding site [nucleotide binding]; DNA binding site 443150001310 FCD domain; Region: FCD; pfam07729 443150001311 exopolyphosphatase; Region: exo_poly_only; TIGR03706 443150001312 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 443150001313 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 443150001314 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 443150001315 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 443150001316 Diacylglycerol kinase catalytic domain (presumed); Region: DAGKc; smart00046 443150001317 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 443150001318 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 443150001319 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 443150001320 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 443150001321 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 443150001322 putative NAD(P) binding site [chemical binding]; other site 443150001323 active site 443150001324 putative substrate binding site [chemical binding]; other site 443150001325 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 443150001326 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 443150001327 putative acyl-acceptor binding pocket; other site 443150001328 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 443150001329 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 443150001330 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443150001331 S-adenosylmethionine binding site [chemical binding]; other site 443150001332 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 443150001333 active site 443150001334 catalytic site [active] 443150001335 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 443150001336 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 443150001337 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 443150001338 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 443150001339 glutamyl-tRNA reductase; Region: hemA; TIGR01035 443150001340 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 443150001341 tRNA; other site 443150001342 putative tRNA binding site [nucleotide binding]; other site 443150001343 putative NADP binding site [chemical binding]; other site 443150001344 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 443150001345 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 443150001346 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 443150001347 domain interfaces; other site 443150001348 active site 443150001349 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 443150001350 active site 443150001351 homodimer interface [polypeptide binding]; other site 443150001352 SAM binding site [chemical binding]; other site 443150001353 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 443150001354 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 443150001355 active site 443150001356 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 443150001357 dimer interface [polypeptide binding]; other site 443150001358 active site 443150001359 Schiff base residues; other site 443150001360 Domain of unknown function (DUF222); Region: DUF222; pfam02720 443150001361 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 443150001362 active site 443150001363 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 443150001364 anti sigma factor interaction site; other site 443150001365 regulatory phosphorylation site [posttranslational modification]; other site 443150001366 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 443150001367 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 443150001368 active site 443150001369 catalytic triad [active] 443150001370 oxyanion hole [active] 443150001371 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 443150001372 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443150001373 Methyltransferase domain; Region: Methyltransf_31; pfam13847 443150001374 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 443150001375 Domain of unknown function (DUF385); Region: DUF385; pfam04075 443150001376 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 443150001377 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 443150001378 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443150001379 catalytic residue [active] 443150001380 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 443150001381 catalytic core [active] 443150001382 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 443150001383 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 443150001384 catalytic residues [active] 443150001385 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 443150001386 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 443150001387 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 443150001388 ResB-like family; Region: ResB; pfam05140 443150001389 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 443150001390 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 443150001391 AAA domain; Region: AAA_31; pfam13614 443150001392 P-loop; other site 443150001393 Magnesium ion binding site [ion binding]; other site 443150001394 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 443150001395 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 443150001396 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 443150001397 UbiA prenyltransferase family; Region: UbiA; pfam01040 443150001398 5'-methylthioadenosine phosphorylase; Validated; Region: PRK07823 443150001399 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 443150001400 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443150001401 NAD(P) binding site [chemical binding]; other site 443150001402 active site 443150001403 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 443150001404 Ligand binding site; other site 443150001405 Putative Catalytic site; other site 443150001406 DXD motif; other site 443150001407 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3222 443150001408 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 443150001409 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443150001410 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443150001411 acyl-activating enzyme (AAE) consensus motif; other site 443150001412 acyl-activating enzyme (AAE) consensus motif; other site 443150001413 AMP binding site [chemical binding]; other site 443150001414 active site 443150001415 CoA binding site [chemical binding]; other site 443150001416 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 443150001417 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 443150001418 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443150001419 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 443150001420 active site 443150001421 short chain dehydrogenase; Provisional; Region: PRK05866 443150001422 classical (c) SDRs; Region: SDR_c; cd05233 443150001423 NAD(P) binding site [chemical binding]; other site 443150001424 active site 443150001425 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443150001426 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 443150001427 substrate binding site [chemical binding]; other site 443150001428 oxyanion hole (OAH) forming residues; other site 443150001429 trimer interface [polypeptide binding]; other site 443150001430 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 443150001431 putative active site [active] 443150001432 homotetrameric interface [polypeptide binding]; other site 443150001433 metal binding site [ion binding]; metal-binding site 443150001434 acyl-CoA synthetase; Validated; Region: PRK06188 443150001435 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 443150001436 putative active site [active] 443150001437 putative CoA binding site [chemical binding]; other site 443150001438 putative AMP binding site [chemical binding]; other site 443150001439 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 443150001440 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 443150001441 active site 443150001442 O-succinylbenzoate synthase; Provisional; Region: PRK02901 443150001443 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 443150001444 active site 443150001445 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443150001446 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 443150001447 TAP-like protein; Region: Abhydrolase_4; pfam08386 443150001448 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 443150001449 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 443150001450 dimer interface [polypeptide binding]; other site 443150001451 tetramer interface [polypeptide binding]; other site 443150001452 PYR/PP interface [polypeptide binding]; other site 443150001453 TPP binding site [chemical binding]; other site 443150001454 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 443150001455 TPP-binding site; other site 443150001456 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 443150001457 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443150001458 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 443150001459 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 443150001460 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443150001461 S-adenosylmethionine binding site [chemical binding]; other site 443150001462 Protein of unknown function (DUF732); Region: DUF732; pfam05305 443150001463 Methyltransferase domain; Region: Methyltransf_23; pfam13489 443150001464 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443150001465 S-adenosylmethionine binding site [chemical binding]; other site 443150001466 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 443150001467 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 443150001468 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 443150001469 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 443150001470 substrate binding pocket [chemical binding]; other site 443150001471 chain length determination region; other site 443150001472 substrate-Mg2+ binding site; other site 443150001473 catalytic residues [active] 443150001474 aspartate-rich region 1; other site 443150001475 active site lid residues [active] 443150001476 aspartate-rich region 2; other site 443150001477 heat shock protein HtpX; Provisional; Region: PRK03072 443150001478 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439 443150001479 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 443150001480 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 443150001481 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 443150001482 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 443150001483 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 443150001484 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 443150001485 O-methyltransferase; Region: Methyltransf_2; pfam00891 443150001486 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443150001487 Cytochrome P450; Region: p450; cl12078 443150001488 ATP cone domain; Region: ATP-cone; pfam03477 443150001489 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 443150001490 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 443150001491 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 443150001492 active site 443150001493 dimer interface [polypeptide binding]; other site 443150001494 effector binding site; other site 443150001495 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 443150001496 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 443150001497 active site 443150001498 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 443150001499 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 443150001500 nicotinate phosphoribosyltransferase; Provisional; Region: PRK12484 443150001501 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 443150001502 active site 443150001503 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 443150001504 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 443150001505 putative active site [active] 443150001506 putative metal binding site [ion binding]; other site 443150001507 hypothetical protein; Provisional; Region: PRK07588 443150001508 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 443150001509 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443150001510 dimerization interface [polypeptide binding]; other site 443150001511 putative DNA binding site [nucleotide binding]; other site 443150001512 putative Zn2+ binding site [ion binding]; other site 443150001513 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 443150001514 putative hydrophobic ligand binding site [chemical binding]; other site 443150001515 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 443150001516 TIGR03086 family protein; Region: TIGR03086 443150001517 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 443150001518 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443150001519 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 443150001520 potential frameshift: common BLAST hit: gi|378770330|ref|YP_005170063.1| PE-PGRS family protein 443150001521 PE family; Region: PE; pfam00934 443150001522 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451 443150001523 Uncharacterized conserved protein [Function unknown]; Region: COG1656 443150001524 Protein of unknown function DUF82; Region: DUF82; pfam01927 443150001525 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 443150001526 putative active site [active] 443150001527 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 443150001528 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 443150001529 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 443150001530 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 443150001531 Transcriptional regulators [Transcription]; Region: FadR; COG2186 443150001532 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443150001533 DNA-binding site [nucleotide binding]; DNA binding site 443150001534 FCD domain; Region: FCD; pfam07729 443150001535 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 443150001536 Permease; Region: Permease; pfam02405 443150001537 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 443150001538 Permease; Region: Permease; pfam02405 443150001539 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443150001540 mce related protein; Region: MCE; pfam02470 443150001541 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 443150001542 mce related protein; Region: MCE; pfam02470 443150001543 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 443150001544 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 443150001545 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443150001546 mce related protein; Region: MCE; pfam02470 443150001547 mce related protein; Region: MCE; pfam02470 443150001548 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443150001549 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 443150001550 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443150001551 mce related protein; Region: MCE; pfam02470 443150001552 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443150001553 mce related protein; Region: MCE; pfam02470 443150001554 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 443150001555 oligomeric interface; other site 443150001556 putative active site [active] 443150001557 homodimer interface [polypeptide binding]; other site 443150001558 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 443150001559 AAA domain; Region: AAA_14; pfam13173 443150001560 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443150001561 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443150001562 ATP binding site [chemical binding]; other site 443150001563 Mg2+ binding site [ion binding]; other site 443150001564 G-X-G motif; other site 443150001565 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443150001566 dimerization interface [polypeptide binding]; other site 443150001567 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 443150001568 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443150001569 active site 443150001570 phosphorylation site [posttranslational modification] 443150001571 intermolecular recognition site; other site 443150001572 dimerization interface [polypeptide binding]; other site 443150001573 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443150001574 DNA binding site [nucleotide binding] 443150001575 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 443150001576 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 443150001577 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 443150001578 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 443150001579 catalytic residues [active] 443150001580 catalytic nucleophile [active] 443150001581 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 443150001582 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 443150001583 Probable transposase; Region: OrfB_IS605; pfam01385 443150001584 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 443150001585 putative active site [active] 443150001586 SEC-C motif; Region: SEC-C; pfam02810 443150001587 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB-like; cd09875 443150001588 putative active site [active] 443150001589 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 443150001590 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 443150001591 nucleotide binding site/active site [active] 443150001592 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 443150001593 galactokinase; Provisional; Region: PRK00555 443150001594 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 443150001595 potential frameshift: common BLAST hit: gi|375294836|ref|YP_005099103.1| membrane protein 443150001596 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 443150001597 putative active site [active] 443150001598 Uncharacterized conserved protein [Function unknown]; Region: COG0398 443150001599 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 443150001600 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 443150001601 oligomeric interface; other site 443150001602 putative active site [active] 443150001603 homodimer interface [polypeptide binding]; other site 443150001604 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 443150001605 FIST N domain; Region: FIST; pfam08495 443150001606 FIST C domain; Region: FIST_C; pfam10442 443150001607 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 443150001608 AAA domain; Region: AAA_30; pfam13604 443150001609 Family description; Region: UvrD_C_2; pfam13538 443150001610 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 443150001611 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 443150001612 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 443150001613 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 443150001614 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 443150001615 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443150001616 substrate binding site [chemical binding]; other site 443150001617 oxyanion hole (OAH) forming residues; other site 443150001618 trimer interface [polypeptide binding]; other site 443150001619 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 443150001620 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 443150001621 active site 443150001622 catalytic site [active] 443150001623 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 443150001624 active site 443150001625 catalytic site [active] 443150001626 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 443150001627 active site 443150001628 catalytic site [active] 443150001629 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 443150001630 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 443150001631 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 443150001632 putative homodimer interface [polypeptide binding]; other site 443150001633 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 443150001634 heterodimer interface [polypeptide binding]; other site 443150001635 homodimer interface [polypeptide binding]; other site 443150001636 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 443150001637 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 443150001638 23S rRNA interface [nucleotide binding]; other site 443150001639 L7/L12 interface [polypeptide binding]; other site 443150001640 putative thiostrepton binding site; other site 443150001641 L25 interface [polypeptide binding]; other site 443150001642 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 443150001643 mRNA/rRNA interface [nucleotide binding]; other site 443150001644 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 443150001645 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443150001646 S-adenosylmethionine binding site [chemical binding]; other site 443150001647 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 443150001648 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 443150001649 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443150001650 S-adenosylmethionine binding site [chemical binding]; other site 443150001651 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 443150001652 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 443150001653 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443150001654 S-adenosylmethionine binding site [chemical binding]; other site 443150001655 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 443150001656 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 443150001657 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443150001658 S-adenosylmethionine binding site [chemical binding]; other site 443150001659 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443150001660 TAP-like protein; Region: Abhydrolase_4; pfam08386 443150001661 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 443150001662 ABC1 family; Region: ABC1; cl17513 443150001663 N-terminal catalytic domain of class II alpha-mannosidases and similar proteins; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_like; cd10786 443150001664 active site 443150001665 catalytic site [active] 443150001666 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 443150001667 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 443150001668 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 443150001669 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 443150001670 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 443150001671 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 443150001672 23S rRNA interface [nucleotide binding]; other site 443150001673 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 443150001674 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 443150001675 core dimer interface [polypeptide binding]; other site 443150001676 peripheral dimer interface [polypeptide binding]; other site 443150001677 L10 interface [polypeptide binding]; other site 443150001678 L11 interface [polypeptide binding]; other site 443150001679 putative EF-Tu interaction site [polypeptide binding]; other site 443150001680 putative EF-G interaction site [polypeptide binding]; other site 443150001681 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443150001682 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443150001683 WHG domain; Region: WHG; pfam13305 443150001684 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 443150001685 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 443150001686 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 443150001687 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 443150001688 Walker A/P-loop; other site 443150001689 ATP binding site [chemical binding]; other site 443150001690 Q-loop/lid; other site 443150001691 ABC transporter signature motif; other site 443150001692 Walker B; other site 443150001693 D-loop; other site 443150001694 H-loop/switch region; other site 443150001695 CAAX protease self-immunity; Region: Abi; cl00558 443150001696 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG1848 443150001697 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 443150001698 Sulfatase; Region: Sulfatase; pfam00884 443150001699 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 443150001700 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 443150001701 putative active site [active] 443150001702 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 443150001703 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 443150001704 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 443150001705 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 443150001706 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 443150001707 RPB10 interaction site [polypeptide binding]; other site 443150001708 RPB1 interaction site [polypeptide binding]; other site 443150001709 RPB11 interaction site [polypeptide binding]; other site 443150001710 RPB3 interaction site [polypeptide binding]; other site 443150001711 RPB12 interaction site [polypeptide binding]; other site 443150001712 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 443150001713 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 443150001714 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 443150001715 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 443150001716 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 443150001717 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 443150001718 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 443150001719 G-loop; other site 443150001720 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 443150001721 DNA binding site [nucleotide binding] 443150001722 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 443150001723 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; pfam04734 443150001724 endonuclease IV; Provisional; Region: PRK01060 443150001725 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 443150001726 AP (apurinic/apyrimidinic) site pocket; other site 443150001727 DNA interaction; other site 443150001728 Metal-binding active site; metal-binding site 443150001729 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 443150001730 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 443150001731 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443150001732 active site 443150001733 enoyl-CoA hydratase; Provisional; Region: PRK12478 443150001734 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443150001735 substrate binding site [chemical binding]; other site 443150001736 oxyanion hole (OAH) forming residues; other site 443150001737 trimer interface [polypeptide binding]; other site 443150001738 Phenylacetic acid-responsive transcriptional repressor [Transcription]; Region: PaaX; COG3327 443150001739 PaaX-like protein; Region: PaaX; pfam07848 443150001740 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 443150001741 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 443150001742 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443150001743 substrate binding site [chemical binding]; other site 443150001744 oxyanion hole (OAH) forming residues; other site 443150001745 trimer interface [polypeptide binding]; other site 443150001746 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 443150001747 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 443150001748 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 443150001749 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 443150001750 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443150001751 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443150001752 WHG domain; Region: WHG; pfam13305 443150001753 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 443150001754 S17 interaction site [polypeptide binding]; other site 443150001755 S8 interaction site; other site 443150001756 16S rRNA interaction site [nucleotide binding]; other site 443150001757 streptomycin interaction site [chemical binding]; other site 443150001758 23S rRNA interaction site [nucleotide binding]; other site 443150001759 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 443150001760 30S ribosomal protein S7; Validated; Region: PRK05302 443150001761 elongation factor G; Reviewed; Region: PRK00007 443150001762 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 443150001763 G1 box; other site 443150001764 putative GEF interaction site [polypeptide binding]; other site 443150001765 GTP/Mg2+ binding site [chemical binding]; other site 443150001766 Switch I region; other site 443150001767 G2 box; other site 443150001768 G3 box; other site 443150001769 Switch II region; other site 443150001770 G4 box; other site 443150001771 G5 box; other site 443150001772 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 443150001773 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 443150001774 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 443150001775 elongation factor Tu; Reviewed; Region: PRK00049 443150001776 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 443150001777 G1 box; other site 443150001778 GEF interaction site [polypeptide binding]; other site 443150001779 GTP/Mg2+ binding site [chemical binding]; other site 443150001780 Switch I region; other site 443150001781 G2 box; other site 443150001782 G3 box; other site 443150001783 Switch II region; other site 443150001784 G4 box; other site 443150001785 G5 box; other site 443150001786 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 443150001787 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 443150001788 Antibiotic Binding Site [chemical binding]; other site 443150001789 Short C-terminal domain; Region: SHOCT; pfam09851 443150001790 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 443150001791 classical (c) SDRs; Region: SDR_c; cd05233 443150001792 NAD(P) binding site [chemical binding]; other site 443150001793 active site 443150001794 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 443150001795 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443150001796 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; cl01837 443150001797 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 443150001798 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443150001799 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 443150001800 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 443150001801 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443150001802 FeS/SAM binding site; other site 443150001803 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 443150001804 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 443150001805 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 443150001806 phosphate binding site [ion binding]; other site 443150001807 mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964 443150001808 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 443150001809 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 443150001810 Probable Catalytic site; other site 443150001811 metal-binding site 443150001812 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 443150001813 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 443150001814 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 443150001815 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 443150001816 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 443150001817 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 443150001818 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 443150001819 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 443150001820 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 443150001821 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 443150001822 putative translocon binding site; other site 443150001823 protein-rRNA interface [nucleotide binding]; other site 443150001824 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 443150001825 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 443150001826 G-X-X-G motif; other site 443150001827 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 443150001828 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 443150001829 23S rRNA interface [nucleotide binding]; other site 443150001830 5S rRNA interface [nucleotide binding]; other site 443150001831 putative antibiotic binding site [chemical binding]; other site 443150001832 L25 interface [polypeptide binding]; other site 443150001833 L27 interface [polypeptide binding]; other site 443150001834 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 443150001835 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 443150001836 Sulfatase; Region: Sulfatase; pfam00884 443150001837 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353 443150001838 Uncharacterized conserved protein [Function unknown]; Region: COG1262 443150001839 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 443150001840 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 443150001841 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 443150001842 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 443150001843 RNA binding site [nucleotide binding]; other site 443150001844 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 443150001845 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 443150001846 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 443150001847 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 443150001848 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 443150001849 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 443150001850 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 443150001851 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 443150001852 5S rRNA interface [nucleotide binding]; other site 443150001853 23S rRNA interface [nucleotide binding]; other site 443150001854 L5 interface [polypeptide binding]; other site 443150001855 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 443150001856 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 443150001857 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 443150001858 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 443150001859 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 443150001860 tandem repeat interface [polypeptide binding]; other site 443150001861 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 443150001862 oligomer interface [polypeptide binding]; other site 443150001863 active site residues [active] 443150001864 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 443150001865 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 443150001866 tandem repeat interface [polypeptide binding]; other site 443150001867 oligomer interface [polypeptide binding]; other site 443150001868 active site residues [active] 443150001869 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 443150001870 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 443150001871 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 443150001872 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 443150001873 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 443150001874 intersubunit interface [polypeptide binding]; other site 443150001875 active site 443150001876 Zn2+ binding site [ion binding]; other site 443150001877 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 443150001878 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 443150001879 NAD binding site [chemical binding]; other site 443150001880 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 443150001881 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 443150001882 nucleotide binding site [chemical binding]; other site 443150001883 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 443150001884 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443150001885 Coenzyme A binding pocket [chemical binding]; other site 443150001886 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 443150001887 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 443150001888 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 443150001889 SecY translocase; Region: SecY; pfam00344 443150001890 adenylate kinase; Reviewed; Region: adk; PRK00279 443150001891 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 443150001892 AMP-binding site [chemical binding]; other site 443150001893 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 443150001894 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 443150001895 active site 443150001896 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 443150001897 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443150001898 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443150001899 DNA binding residues [nucleotide binding] 443150001900 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 443150001901 Putative zinc-finger; Region: zf-HC2; pfam13490 443150001902 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 443150001903 MarR family; Region: MarR; pfam01047 443150001904 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 443150001905 TIGR03086 family protein; Region: TIGR03086 443150001906 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 443150001907 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 443150001908 Transposase; Region: DDE_Tnp_ISL3; pfam01610 443150001909 Helix-turn-helix domain; Region: HTH_17; pfam12728 443150001910 PE family; Region: PE; pfam00934 443150001911 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 443150001912 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 443150001913 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 443150001914 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443150001915 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443150001916 active site 443150001917 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 443150001918 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 443150001919 tetrameric interface [polypeptide binding]; other site 443150001920 NAD binding site [chemical binding]; other site 443150001921 catalytic residues [active] 443150001922 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 443150001923 catalytic core [active] 443150001924 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150001925 PPE family; Region: PPE; pfam00823 443150001926 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443150001927 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443150001928 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 443150001929 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443150001930 active site 443150001931 phosphorylation site [posttranslational modification] 443150001932 intermolecular recognition site; other site 443150001933 dimerization interface [polypeptide binding]; other site 443150001934 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443150001935 DNA binding site [nucleotide binding] 443150001936 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443150001937 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443150001938 dimerization interface [polypeptide binding]; other site 443150001939 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443150001940 dimer interface [polypeptide binding]; other site 443150001941 phosphorylation site [posttranslational modification] 443150001942 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443150001943 ATP binding site [chemical binding]; other site 443150001944 Mg2+ binding site [ion binding]; other site 443150001945 G-X-G motif; other site 443150001946 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 443150001947 nucleotide binding site/active site [active] 443150001948 HIT family signature motif; other site 443150001949 catalytic residue [active] 443150001950 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 443150001951 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 443150001952 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 443150001953 NAD binding site [chemical binding]; other site 443150001954 catalytic Zn binding site [ion binding]; other site 443150001955 substrate binding site [chemical binding]; other site 443150001956 structural Zn binding site [ion binding]; other site 443150001957 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 443150001958 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443150001959 Cytochrome P450; Region: p450; cl12078 443150001960 short chain dehydrogenase; Provisional; Region: PRK07775 443150001961 classical (c) SDRs; Region: SDR_c; cd05233 443150001962 NAD(P) binding site [chemical binding]; other site 443150001963 active site 443150001964 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443150001965 Cytochrome P450; Region: p450; cl12078 443150001966 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443150001967 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 443150001968 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 443150001969 NAD binding site [chemical binding]; other site 443150001970 catalytic residues [active] 443150001971 short chain dehydrogenase; Provisional; Region: PRK07774 443150001972 classical (c) SDRs; Region: SDR_c; cd05233 443150001973 NAD(P) binding site [chemical binding]; other site 443150001974 active site 443150001975 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 443150001976 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 443150001977 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 443150001978 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 443150001979 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 443150001980 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 443150001981 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 443150001982 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 443150001983 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 443150001984 Predicted esterase [General function prediction only]; Region: COG0627 443150001985 S-formylglutathione hydrolase; Region: PLN02442 443150001986 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 443150001987 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 443150001988 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 443150001989 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 443150001990 tetramer interface [polypeptide binding]; other site 443150001991 active site 443150001992 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443150001993 Cytochrome P450; Region: p450; cl12078 443150001994 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 443150001995 ATP binding site [chemical binding]; other site 443150001996 active site 443150001997 substrate binding site [chemical binding]; other site 443150001998 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 443150001999 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 443150002000 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 443150002001 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443150002002 putative substrate translocation pore; other site 443150002003 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443150002004 Predicted deacetylase [General function prediction only]; Region: COG3233 443150002005 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 443150002006 putative active site [active] 443150002007 putative Zn binding site [ion binding]; other site 443150002008 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 443150002009 FAD binding domain; Region: FAD_binding_2; pfam00890 443150002010 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 443150002011 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 443150002012 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 443150002013 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 443150002014 putative active site [active] 443150002015 catalytic triad [active] 443150002016 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 443150002017 Transglutaminase/protease-like homologues; Region: TGc; smart00460 443150002018 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 443150002019 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 443150002020 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 443150002021 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 443150002022 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443150002023 DNA-binding site [nucleotide binding]; DNA binding site 443150002024 UTRA domain; Region: UTRA; pfam07702 443150002025 Uncharacterized conserved protein [Function unknown]; Region: COG1359 443150002026 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 443150002027 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 443150002028 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443150002029 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 443150002030 putative transposase OrfB; Reviewed; Region: PHA02517 443150002031 HTH-like domain; Region: HTH_21; pfam13276 443150002032 Integrase core domain; Region: rve; pfam00665 443150002033 Integrase core domain; Region: rve_3; pfam13683 443150002034 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 443150002035 Transposase; Region: DEDD_Tnp_IS110; pfam01548 443150002036 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 443150002037 Uncharacterized protein, linocin/CFP29 homolog [Function unknown]; Region: COG1659 443150002038 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 443150002039 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 443150002040 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 443150002041 active site 443150002042 metal binding site [ion binding]; metal-binding site 443150002043 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 443150002044 active site 443150002045 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443150002046 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 443150002047 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 443150002048 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 443150002049 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 443150002050 dimerization interface [polypeptide binding]; other site 443150002051 ATP binding site [chemical binding]; other site 443150002052 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 443150002053 dimerization interface [polypeptide binding]; other site 443150002054 ATP binding site [chemical binding]; other site 443150002055 CAAX protease self-immunity; Region: Abi; pfam02517 443150002056 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 443150002057 amidophosphoribosyltransferase; Provisional; Region: PRK07847 443150002058 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 443150002059 active site 443150002060 tetramer interface [polypeptide binding]; other site 443150002061 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 443150002062 active site 443150002063 phosphoribosylaminoimidazole synthetase; Region: purM; TIGR00878 443150002064 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 443150002065 dimerization interface [polypeptide binding]; other site 443150002066 putative ATP binding site [chemical binding]; other site 443150002067 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 443150002068 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 443150002069 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 443150002070 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 443150002071 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443150002072 catalytic residue [active] 443150002073 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 443150002074 heme-binding site [chemical binding]; other site 443150002075 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 443150002076 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 443150002077 active site residue [active] 443150002078 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 443150002079 active site residue [active] 443150002080 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 443150002081 catalytic residues [active] 443150002082 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 443150002083 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 443150002084 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443150002085 DNA binding site [nucleotide binding] 443150002086 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 443150002087 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443150002088 Coenzyme A binding pocket [chemical binding]; other site 443150002089 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 443150002090 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 443150002091 Walker A/P-loop; other site 443150002092 ATP binding site [chemical binding]; other site 443150002093 Q-loop/lid; other site 443150002094 ABC transporter signature motif; other site 443150002095 Walker B; other site 443150002096 D-loop; other site 443150002097 H-loop/switch region; other site 443150002098 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 443150002099 PhoU domain; Region: PhoU; pfam01895 443150002100 PhoU domain; Region: PhoU; pfam01895 443150002101 cell envelope-related function transcriptional attenuator common domain; Region: lytR_cpsA_psr; TIGR00350 443150002102 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 443150002103 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 443150002104 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 443150002105 FMN binding site [chemical binding]; other site 443150002106 active site 443150002107 catalytic residues [active] 443150002108 substrate binding site [chemical binding]; other site 443150002109 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 443150002110 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 443150002111 homodimer interface [polypeptide binding]; other site 443150002112 putative substrate binding pocket [chemical binding]; other site 443150002113 diiron center [ion binding]; other site 443150002114 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 443150002115 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443150002116 dimerization interface [polypeptide binding]; other site 443150002117 putative DNA binding site [nucleotide binding]; other site 443150002118 putative Zn2+ binding site [ion binding]; other site 443150002119 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 443150002120 dimer interface [polypeptide binding]; other site 443150002121 catalytic motif [active] 443150002122 nucleoside/Zn binding site; other site 443150002123 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 443150002124 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 443150002125 TIGR04255 family protein; Region: sporadTIGR04255 443150002126 PE family; Region: PE; pfam00934 443150002127 PE family; Region: PE; pfam00934 443150002128 PknH-like extracellular domain; Region: PknH_C; pfam14032 443150002129 Predicted nucleotidyltransferase [General function prediction only]; Region: COG4849 443150002130 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4861 443150002131 Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952 443150002132 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 443150002133 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443150002134 S-adenosylmethionine binding site [chemical binding]; other site 443150002135 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 443150002136 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443150002137 putative substrate translocation pore; other site 443150002138 Major Facilitator Superfamily; Region: MFS_1; pfam07690 443150002139 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 443150002140 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 443150002141 tetramer interface [polypeptide binding]; other site 443150002142 TPP-binding site [chemical binding]; other site 443150002143 heterodimer interface [polypeptide binding]; other site 443150002144 phosphorylation loop region [posttranslational modification] 443150002145 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443150002146 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443150002147 active site 443150002148 phosphorylation site [posttranslational modification] 443150002149 intermolecular recognition site; other site 443150002150 dimerization interface [polypeptide binding]; other site 443150002151 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443150002152 DNA binding residues [nucleotide binding] 443150002153 dimerization interface [polypeptide binding]; other site 443150002154 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 443150002155 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 443150002156 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 443150002157 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 443150002158 Multicopper oxidase; Region: Cu-oxidase; pfam00394 443150002159 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 443150002160 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 443150002161 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 443150002162 dimer interface [polypeptide binding]; other site 443150002163 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443150002164 catalytic residue [active] 443150002165 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443150002166 multidrug resistance protein MdtH; Provisional; Region: PRK11646 443150002167 putative substrate translocation pore; other site 443150002168 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 443150002169 short chain dehydrogenase; Provisional; Region: PRK05876 443150002170 classical (c) SDRs; Region: SDR_c; cd05233 443150002171 NAD(P) binding site [chemical binding]; other site 443150002172 active site 443150002173 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443150002174 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 443150002175 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 443150002176 dimer interface [polypeptide binding]; other site 443150002177 PYR/PP interface [polypeptide binding]; other site 443150002178 TPP binding site [chemical binding]; other site 443150002179 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 443150002180 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 443150002181 TPP-binding site [chemical binding]; other site 443150002182 dimer interface [polypeptide binding]; other site 443150002183 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 443150002184 putative hydrophobic ligand binding site [chemical binding]; other site 443150002185 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 443150002186 CoA-transferase family III; Region: CoA_transf_3; pfam02515 443150002187 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 443150002188 putative hydrophobic ligand binding site [chemical binding]; other site 443150002189 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 443150002190 putative hydrophobic ligand binding site [chemical binding]; other site 443150002191 aminotransferase; Validated; Region: PRK07777 443150002192 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443150002193 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443150002194 homodimer interface [polypeptide binding]; other site 443150002195 catalytic residue [active] 443150002196 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 443150002197 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 443150002198 dimer interface [polypeptide binding]; other site 443150002199 active site 443150002200 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 443150002201 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443150002202 substrate binding site [chemical binding]; other site 443150002203 oxyanion hole (OAH) forming residues; other site 443150002204 trimer interface [polypeptide binding]; other site 443150002205 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 443150002206 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 443150002207 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 443150002208 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 443150002209 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443150002210 ATP binding site [chemical binding]; other site 443150002211 putative Mg++ binding site [ion binding]; other site 443150002212 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443150002213 nucleotide binding region [chemical binding]; other site 443150002214 ATP-binding site [chemical binding]; other site 443150002215 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 443150002216 WYL domain; Region: WYL; pfam13280 443150002217 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 443150002218 trimer interface [polypeptide binding]; other site 443150002219 dimer interface [polypeptide binding]; other site 443150002220 putative active site [active] 443150002221 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 443150002222 MPT binding site; other site 443150002223 trimer interface [polypeptide binding]; other site 443150002224 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 443150002225 MoaE homodimer interface [polypeptide binding]; other site 443150002226 MoaD interaction [polypeptide binding]; other site 443150002227 active site residues [active] 443150002228 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 443150002229 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 443150002230 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443150002231 FeS/SAM binding site; other site 443150002232 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 443150002233 hypothetical protein; Provisional; Region: PRK11770 443150002234 Domain of unknown function (DUF307); Region: DUF307; pfam03733 443150002235 Domain of unknown function (DUF307); Region: DUF307; pfam03733 443150002236 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 443150002237 DNA-binding site [nucleotide binding]; DNA binding site 443150002238 RNA-binding motif; other site 443150002239 PE family; Region: PE; pfam00934 443150002240 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443150002241 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443150002242 active site 443150002243 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 443150002244 FIST N domain; Region: FIST; pfam08495 443150002245 FIST C domain; Region: FIST_C; pfam10442 443150002246 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 443150002247 H+ Antiporter protein; Region: 2A0121; TIGR00900 443150002248 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 443150002249 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150002250 PPE family; Region: PPE; pfam00823 443150002251 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443150002252 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443150002253 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 443150002254 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 443150002255 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 443150002256 phosphoserine aminotransferase, putative; Region: serC_3; TIGR01366 443150002257 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443150002258 catalytic residue [active] 443150002259 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 443150002260 Ferredoxin [Energy production and conversion]; Region: COG1146 443150002261 4Fe-4S binding domain; Region: Fer4; pfam00037 443150002262 ferredoxin-NADP+ reductase; Region: PLN02852 443150002263 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 443150002264 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 443150002265 putative dimer interface [polypeptide binding]; other site 443150002266 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443150002267 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 443150002268 putative catalytic site [active] 443150002269 putative phosphate binding site [ion binding]; other site 443150002270 putative metal binding site [ion binding]; other site 443150002271 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 443150002272 dimer interface [polypeptide binding]; other site 443150002273 Citrate synthase; Region: Citrate_synt; pfam00285 443150002274 active site 443150002275 citrylCoA binding site [chemical binding]; other site 443150002276 oxalacetate/citrate binding site [chemical binding]; other site 443150002277 coenzyme A binding site [chemical binding]; other site 443150002278 catalytic triad [active] 443150002279 Predicted ATPase [General function prediction only]; Region: COG3903 443150002280 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443150002281 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443150002282 DNA binding residues [nucleotide binding] 443150002283 dimerization interface [polypeptide binding]; other site 443150002284 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 443150002285 cyclase homology domain; Region: CHD; cd07302 443150002286 nucleotidyl binding site; other site 443150002287 metal binding site [ion binding]; metal-binding site 443150002288 dimer interface [polypeptide binding]; other site 443150002289 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 443150002290 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 443150002291 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 443150002292 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 443150002293 AAA ATPase domain; Region: AAA_16; pfam13191 443150002294 Predicted ATPase [General function prediction only]; Region: COG3903 443150002295 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443150002296 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443150002297 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 443150002298 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 443150002299 dimer interface [polypeptide binding]; other site 443150002300 active site 443150002301 citrylCoA binding site [chemical binding]; other site 443150002302 NADH binding [chemical binding]; other site 443150002303 cationic pore residues; other site 443150002304 oxalacetate/citrate binding site [chemical binding]; other site 443150002305 coenzyme A binding site [chemical binding]; other site 443150002306 catalytic triad [active] 443150002307 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 443150002308 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 443150002309 BON domain; Region: BON; pfam04972 443150002310 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 443150002311 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 443150002312 ligand binding site [chemical binding]; other site 443150002313 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 443150002314 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443150002315 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443150002316 dimerization interface [polypeptide binding]; other site 443150002317 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443150002318 dimer interface [polypeptide binding]; other site 443150002319 phosphorylation site [posttranslational modification] 443150002320 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443150002321 Mg2+ binding site [ion binding]; other site 443150002322 G-X-G motif; other site 443150002323 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 443150002324 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443150002325 active site 443150002326 phosphorylation site [posttranslational modification] 443150002327 intermolecular recognition site; other site 443150002328 dimerization interface [polypeptide binding]; other site 443150002329 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443150002330 DNA binding site [nucleotide binding] 443150002331 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 443150002332 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; COG0825 443150002333 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 443150002334 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443150002335 substrate binding site [chemical binding]; other site 443150002336 oxyanion hole (OAH) forming residues; other site 443150002337 trimer interface [polypeptide binding]; other site 443150002338 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 443150002339 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 443150002340 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 443150002341 Beta-lactamase; Region: Beta-lactamase; pfam00144 443150002342 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 443150002343 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 443150002344 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 443150002345 Soluble P-type ATPase [General function prediction only]; Region: COG4087 443150002346 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 443150002347 hydrophobic ligand binding site; other site 443150002348 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 443150002349 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443150002350 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 443150002351 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443150002352 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 443150002353 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 443150002354 acetyl-CoA acetyltransferase; Provisional; Region: PRK06289 443150002355 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 443150002356 active site 443150002357 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150002358 PPE family; Region: PPE; pfam00823 443150002359 BCCT family transporter; Region: BCCT; pfam02028 443150002360 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443150002361 Coenzyme A binding pocket [chemical binding]; other site 443150002362 Transposase, Mutator family; Region: Transposase_mut; pfam00872 443150002363 MULE transposase domain; Region: MULE; pfam10551 443150002364 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 443150002365 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 443150002366 catalytic residues [active] 443150002367 catalytic nucleophile [active] 443150002368 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 443150002369 Probable transposase; Region: OrfB_IS605; pfam01385 443150002370 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 443150002371 putative active site pocket [active] 443150002372 dimerization interface [polypeptide binding]; other site 443150002373 putative catalytic residue [active] 443150002374 Phage-related replication protein [General function prediction only]; Region: COG4195 443150002375 manganese transport protein MntH; Reviewed; Region: PRK00701 443150002376 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 443150002377 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 443150002378 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 443150002379 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 443150002380 short chain dehydrogenase; Provisional; Region: PRK07814 443150002381 classical (c) SDRs; Region: SDR_c; cd05233 443150002382 NAD(P) binding site [chemical binding]; other site 443150002383 active site 443150002384 phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975 443150002385 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 443150002386 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443150002387 dimer interface [polypeptide binding]; other site 443150002388 conserved gate region; other site 443150002389 putative PBP binding loops; other site 443150002390 ABC-ATPase subunit interface; other site 443150002391 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 443150002392 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443150002393 dimer interface [polypeptide binding]; other site 443150002394 conserved gate region; other site 443150002395 putative PBP binding loops; other site 443150002396 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 443150002397 ABC-ATPase subunit interface; other site 443150002398 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 443150002399 Catalytic domain of Protein Kinases; Region: PKc; cd00180 443150002400 active site 443150002401 ATP binding site [chemical binding]; other site 443150002402 substrate binding site [chemical binding]; other site 443150002403 activation loop (A-loop); other site 443150002404 Uncharacterized conserved protein [Function unknown]; Region: COG3391 443150002405 NHL repeat; Region: NHL; pfam01436 443150002406 NHL repeat; Region: NHL; pfam01436 443150002407 NHL repeat; Region: NHL; pfam01436 443150002408 NHL repeat; Region: NHL; pfam01436 443150002409 NHL repeat; Region: NHL; pfam01436 443150002410 PBP superfamily domain; Region: PBP_like_2; cl17296 443150002411 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14271 443150002412 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 443150002413 Walker A/P-loop; other site 443150002414 ATP binding site [chemical binding]; other site 443150002415 Q-loop/lid; other site 443150002416 ABC transporter signature motif; other site 443150002417 Walker B; other site 443150002418 D-loop; other site 443150002419 H-loop/switch region; other site 443150002420 phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975 443150002421 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 443150002422 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443150002423 dimer interface [polypeptide binding]; other site 443150002424 conserved gate region; other site 443150002425 putative PBP binding loops; other site 443150002426 ABC-ATPase subunit interface; other site 443150002427 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 443150002428 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443150002429 dimer interface [polypeptide binding]; other site 443150002430 conserved gate region; other site 443150002431 putative PBP binding loops; other site 443150002432 ABC-ATPase subunit interface; other site 443150002433 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 443150002434 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 443150002435 putative DNA binding site [nucleotide binding]; other site 443150002436 putative homodimer interface [polypeptide binding]; other site 443150002437 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 443150002438 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 443150002439 nucleotide binding site [chemical binding]; other site 443150002440 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 443150002441 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 443150002442 active site 443150002443 DNA binding site [nucleotide binding] 443150002444 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 443150002445 DNA binding site [nucleotide binding] 443150002446 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 443150002447 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 443150002448 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 443150002449 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 443150002450 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 443150002451 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 443150002452 anti sigma factor interaction site; other site 443150002453 regulatory phosphorylation site [posttranslational modification]; other site 443150002454 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 443150002455 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 443150002456 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 443150002457 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 443150002458 short chain dehydrogenase; Provisional; Region: PRK08251 443150002459 classical (c) SDR, subgroup 6; Region: SDR_c6; cd05350 443150002460 putative NAD(P) binding site [chemical binding]; other site 443150002461 active site 443150002462 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 443150002463 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 443150002464 active site 443150002465 dimer interface [polypeptide binding]; other site 443150002466 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 443150002467 dimer interface [polypeptide binding]; other site 443150002468 active site 443150002469 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 443150002470 Part of AAA domain; Region: AAA_19; pfam13245 443150002471 Family description; Region: UvrD_C_2; pfam13538 443150002472 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 443150002473 Peptidase family M23; Region: Peptidase_M23; pfam01551 443150002474 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 443150002475 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 443150002476 CoA-ligase; Region: Ligase_CoA; pfam00549 443150002477 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 443150002478 CoA binding domain; Region: CoA_binding; smart00881 443150002479 CoA-ligase; Region: Ligase_CoA; pfam00549 443150002480 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 443150002481 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 443150002482 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 443150002483 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 443150002484 active site 443150002485 cosubstrate binding site; other site 443150002486 substrate binding site [chemical binding]; other site 443150002487 catalytic site [active] 443150002488 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 443150002489 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 443150002490 purine monophosphate binding site [chemical binding]; other site 443150002491 dimer interface [polypeptide binding]; other site 443150002492 putative catalytic residues [active] 443150002493 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 443150002494 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 443150002495 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 443150002496 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 443150002497 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 443150002498 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 443150002499 metal ion-dependent adhesion site (MIDAS); other site 443150002500 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 443150002501 homotetrameric interface [polypeptide binding]; other site 443150002502 putative active site [active] 443150002503 metal binding site [ion binding]; metal-binding site 443150002504 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 443150002505 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 443150002506 Thermus thermophilus CsoR, a Cu(I)-sensing transcriptional regulator, and related domains; this domain family was previously known as part of DUF156; Region: TthCsoR-like_DUF156; cd10151 443150002507 putative homodimer interface [polypeptide binding]; other site 443150002508 putative homotetramer interface [polypeptide binding]; other site 443150002509 allosteric switch controlling residues; other site 443150002510 putative metal binding site [ion binding]; other site 443150002511 putative homodimer-homodimer interface [polypeptide binding]; other site 443150002512 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 443150002513 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 443150002514 Soluble P-type ATPase [General function prediction only]; Region: COG4087 443150002515 enoyl-CoA hydratase; Provisional; Region: PRK07827 443150002516 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443150002517 substrate binding site [chemical binding]; other site 443150002518 oxyanion hole (OAH) forming residues; other site 443150002519 trimer interface [polypeptide binding]; other site 443150002520 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443150002521 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 443150002522 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 443150002523 active site 443150002524 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 443150002525 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 443150002526 ATP-grasp domain; Region: ATP-grasp_4; cl17255 443150002527 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 443150002528 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 443150002529 carboxyltransferase (CT) interaction site; other site 443150002530 biotinylation site [posttranslational modification]; other site 443150002531 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 443150002532 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 443150002533 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443150002534 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443150002535 active site 443150002536 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 443150002537 potential frameshift: common BLAST hit: gi|340625989|ref|YP_004744441.1| PE-PGRS family protein 443150002538 PE family; Region: PE; pfam00934 443150002539 PE family; Region: PE; pfam00934 443150002540 Uncharacterized conserved protein [Function unknown]; Region: COG3391 443150002541 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 443150002542 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 443150002543 PE family; Region: PE; pfam00934 443150002544 Uncharacterized conserved protein [Function unknown]; Region: COG3391 443150002545 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 443150002546 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 443150002547 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 443150002548 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 443150002549 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443150002550 active site 443150002551 phosphorylation site [posttranslational modification] 443150002552 intermolecular recognition site; other site 443150002553 dimerization interface [polypeptide binding]; other site 443150002554 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443150002555 DNA binding site [nucleotide binding] 443150002556 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 443150002557 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443150002558 dimerization interface [polypeptide binding]; other site 443150002559 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443150002560 dimer interface [polypeptide binding]; other site 443150002561 phosphorylation site [posttranslational modification] 443150002562 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443150002563 ATP binding site [chemical binding]; other site 443150002564 Mg2+ binding site [ion binding]; other site 443150002565 G-X-G motif; other site 443150002566 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 443150002567 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 443150002568 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 443150002569 MPT binding site; other site 443150002570 trimer interface [polypeptide binding]; other site 443150002571 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 443150002572 Large-conductance mechanosensitive channel, MscL; Region: MscL; pfam01741 443150002573 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 443150002574 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 443150002575 Walker A/P-loop; other site 443150002576 ATP binding site [chemical binding]; other site 443150002577 Q-loop/lid; other site 443150002578 ABC transporter signature motif; other site 443150002579 Walker B; other site 443150002580 D-loop; other site 443150002581 H-loop/switch region; other site 443150002582 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 443150002583 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 443150002584 FtsX-like permease family; Region: FtsX; pfam02687 443150002585 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 443150002586 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 443150002587 FtsX-like permease family; Region: FtsX; pfam02687 443150002588 Predicted secreted hydrolase [General function prediction only]; Region: COG5621 443150002589 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 443150002590 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 443150002591 substrate binding pocket [chemical binding]; other site 443150002592 chain length determination region; other site 443150002593 substrate-Mg2+ binding site; other site 443150002594 catalytic residues [active] 443150002595 aspartate-rich region 1; other site 443150002596 active site lid residues [active] 443150002597 aspartate-rich region 2; other site 443150002598 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 443150002599 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2331 443150002600 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 443150002601 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 443150002602 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 443150002603 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 443150002604 active site 443150002605 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 443150002606 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 443150002607 dimer interface [polypeptide binding]; other site 443150002608 putative functional site; other site 443150002609 putative MPT binding site; other site 443150002610 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 443150002611 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 443150002612 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443150002613 S-adenosylmethionine binding site [chemical binding]; other site 443150002614 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 443150002615 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 443150002616 ligand binding site [chemical binding]; other site 443150002617 flexible hinge region; other site 443150002618 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 443150002619 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443150002620 Coenzyme A binding pocket [chemical binding]; other site 443150002621 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 443150002622 arginine deiminase; Provisional; Region: PRK01388 443150002623 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 443150002624 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 443150002625 Predicted methyltransferases [General function prediction only]; Region: COG0313 443150002626 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 443150002627 putative SAM binding site [chemical binding]; other site 443150002628 putative homodimer interface [polypeptide binding]; other site 443150002629 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 443150002630 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 443150002631 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 443150002632 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 443150002633 active site 443150002634 HIGH motif; other site 443150002635 KMSKS motif; other site 443150002636 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 443150002637 tRNA binding surface [nucleotide binding]; other site 443150002638 anticodon binding site; other site 443150002639 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 443150002640 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 443150002641 active site 443150002642 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 443150002643 Domain of unknown function (DUF348); Region: DUF348; pfam03990 443150002644 Domain of unknown function (DUF348); Region: DUF348; pfam03990 443150002645 G5 domain; Region: G5; pfam07501 443150002646 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 443150002647 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 443150002648 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443150002649 S-adenosylmethionine binding site [chemical binding]; other site 443150002650 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 443150002651 Increased loss of mitochondrial DNA protein 1; Region: Ilm1; pfam10311 443150002652 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 443150002653 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 443150002654 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443150002655 acyl-activating enzyme (AAE) consensus motif; other site 443150002656 AMP binding site [chemical binding]; other site 443150002657 active site 443150002658 CoA binding site [chemical binding]; other site 443150002659 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 443150002660 putative active site [active] 443150002661 catalytic residue [active] 443150002662 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 443150002663 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 443150002664 5S rRNA interface [nucleotide binding]; other site 443150002665 CTC domain interface [polypeptide binding]; other site 443150002666 L16 interface [polypeptide binding]; other site 443150002667 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 443150002668 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 443150002669 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 443150002670 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 443150002671 active site 443150002672 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 443150002673 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 443150002674 Substrate binding site; other site 443150002675 Mg++ binding site; other site 443150002676 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 443150002677 active site 443150002678 substrate binding site [chemical binding]; other site 443150002679 CoA binding site [chemical binding]; other site 443150002680 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443150002681 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443150002682 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 443150002683 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 443150002684 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443150002685 ATP binding site [chemical binding]; other site 443150002686 putative Mg++ binding site [ion binding]; other site 443150002687 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443150002688 nucleotide binding region [chemical binding]; other site 443150002689 ATP-binding site [chemical binding]; other site 443150002690 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 443150002691 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 443150002692 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 443150002693 homodimer interface [polypeptide binding]; other site 443150002694 metal binding site [ion binding]; metal-binding site 443150002695 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 443150002696 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 443150002697 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 443150002698 N-acetyl-D-glucosamine binding site [chemical binding]; other site 443150002699 enolase; Provisional; Region: eno; PRK00077 443150002700 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 443150002701 dimer interface [polypeptide binding]; other site 443150002702 metal binding site [ion binding]; metal-binding site 443150002703 substrate binding pocket [chemical binding]; other site 443150002704 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 443150002705 Septum formation initiator; Region: DivIC; pfam04977 443150002706 Uncharacterized conserved protein [Function unknown]; Region: COG1507 443150002707 exopolyphosphatase; Region: exo_poly_only; TIGR03706 443150002708 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 443150002709 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 443150002710 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443150002711 active site 443150002712 phosphorylation site [posttranslational modification] 443150002713 intermolecular recognition site; other site 443150002714 dimerization interface [polypeptide binding]; other site 443150002715 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443150002716 DNA binding site [nucleotide binding] 443150002717 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 443150002718 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 443150002719 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 443150002720 Ligand Binding Site [chemical binding]; other site 443150002721 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443150002722 dimer interface [polypeptide binding]; other site 443150002723 phosphorylation site [posttranslational modification] 443150002724 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443150002725 ATP binding site [chemical binding]; other site 443150002726 Mg2+ binding site [ion binding]; other site 443150002727 G-X-G motif; other site 443150002728 K+-transporting ATPase, KdpA; Region: kdpA; TIGR00680 443150002729 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 443150002730 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 443150002731 Soluble P-type ATPase [General function prediction only]; Region: COG4087 443150002732 K+-transporting ATPase, c chain; Region: KdpC; cl00944 443150002733 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443150002734 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443150002735 dimer interface [polypeptide binding]; other site 443150002736 phosphorylation site [posttranslational modification] 443150002737 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443150002738 ATP binding site [chemical binding]; other site 443150002739 Mg2+ binding site [ion binding]; other site 443150002740 G-X-G motif; other site 443150002741 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 443150002742 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443150002743 active site 443150002744 phosphorylation site [posttranslational modification] 443150002745 intermolecular recognition site; other site 443150002746 dimerization interface [polypeptide binding]; other site 443150002747 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443150002748 DNA binding site [nucleotide binding] 443150002749 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 443150002750 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 443150002751 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 443150002752 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150002753 PPE family; Region: PPE; pfam00823 443150002754 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 443150002755 PE family; Region: PE; pfam00934 443150002756 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 443150002757 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 443150002758 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 443150002759 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 443150002760 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 443150002761 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 443150002762 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 443150002763 Transposase, Mutator family; Region: Transposase_mut; pfam00872 443150002764 MULE transposase domain; Region: MULE; pfam10551 443150002765 Transcriptional regulators [Transcription]; Region: MarR; COG1846 443150002766 MarR family; Region: MarR_2; pfam12802 443150002767 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443150002768 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 443150002769 NAD(P) binding site [chemical binding]; other site 443150002770 active site 443150002771 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 443150002772 Helix-turn-helix domain; Region: HTH_17; pfam12728 443150002773 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 443150002774 Domain of unknown function (DUF427); Region: DUF427; cl00998 443150002775 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 443150002776 Uncharacterized conserved protein [Function unknown]; Region: COG3391 443150002777 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 443150002778 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 443150002779 dimer interface [polypeptide binding]; other site 443150002780 acyl-activating enzyme (AAE) consensus motif; other site 443150002781 putative active site [active] 443150002782 AMP binding site [chemical binding]; other site 443150002783 putative CoA binding site [chemical binding]; other site 443150002784 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 443150002785 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 443150002786 hydrophobic ligand binding site; other site 443150002787 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 443150002788 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 443150002789 putative dimer interface [polypeptide binding]; other site 443150002790 putative active site [active] 443150002791 Patatin-like phospholipase; Region: Patatin; pfam01734 443150002792 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 443150002793 nucleophile elbow; other site 443150002794 hypothetical protein; Provisional; Region: PRK10279 443150002795 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 443150002796 active site 443150002797 nucleophile elbow; other site 443150002798 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 443150002799 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 443150002800 active site residue [active] 443150002801 PE family; Region: PE; pfam00934 443150002802 PE family; Region: PE; pfam00934 443150002803 Predicted membrane protein [Function unknown]; Region: COG4425 443150002804 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 443150002805 enoyl-CoA hydratase; Provisional; Region: PRK05862 443150002806 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443150002807 substrate binding site [chemical binding]; other site 443150002808 oxyanion hole (OAH) forming residues; other site 443150002809 trimer interface [polypeptide binding]; other site 443150002810 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 443150002811 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443150002812 substrate binding site [chemical binding]; other site 443150002813 oxyanion hole (OAH) forming residues; other site 443150002814 trimer interface [polypeptide binding]; other site 443150002815 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 443150002816 Predicted membrane protein [Function unknown]; Region: COG4760 443150002817 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 443150002818 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 443150002819 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 443150002820 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 443150002821 dimer interface [polypeptide binding]; other site 443150002822 active site 443150002823 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 443150002824 active site 443150002825 catalytic triad [active] 443150002826 oxyanion hole [active] 443150002827 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 443150002828 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 443150002829 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 443150002830 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 443150002831 dimer interface [polypeptide binding]; other site 443150002832 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443150002833 catalytic residue [active] 443150002834 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 443150002835 RDD family; Region: RDD; pfam06271 443150002836 cystathionine gamma-synthase; Provisional; Region: PRK07811 443150002837 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 443150002838 homodimer interface [polypeptide binding]; other site 443150002839 substrate-cofactor binding pocket; other site 443150002840 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443150002841 catalytic residue [active] 443150002842 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 443150002843 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 443150002844 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 443150002845 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 443150002846 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 443150002847 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 443150002848 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 443150002849 catalytic residues [active] 443150002850 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 443150002851 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 443150002852 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 443150002853 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 443150002854 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 443150002855 catalytic residue [active] 443150002856 putative FPP diphosphate binding site; other site 443150002857 putative FPP binding hydrophobic cleft; other site 443150002858 dimer interface [polypeptide binding]; other site 443150002859 putative IPP diphosphate binding site; other site 443150002860 PE family; Region: PE; pfam00934 443150002861 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 443150002862 putative IPP diphosphate binding site; other site 443150002863 Glycosyl hydrolase family 12; Region: Glyco_hydro_12; pfam01670 443150002864 PE family; Region: PE; pfam00934 443150002865 pantothenate kinase; Provisional; Region: PRK05439 443150002866 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 443150002867 ATP-binding site [chemical binding]; other site 443150002868 CoA-binding site [chemical binding]; other site 443150002869 Mg2+-binding site [ion binding]; other site 443150002870 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 443150002871 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 443150002872 dimer interface [polypeptide binding]; other site 443150002873 active site 443150002874 glycine-pyridoxal phosphate binding site [chemical binding]; other site 443150002875 folate binding site [chemical binding]; other site 443150002876 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 443150002877 dinuclear metal binding motif [ion binding]; other site 443150002878 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 443150002879 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 443150002880 putative active site [active] 443150002881 PhoH-like protein; Region: PhoH; pfam02562 443150002882 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 443150002883 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 443150002884 NodB motif; other site 443150002885 active site 443150002886 catalytic site [active] 443150002887 metal binding site [ion binding]; metal-binding site 443150002888 fumarate hydratase; Reviewed; Region: fumC; PRK00485 443150002889 Class II fumarases; Region: Fumarase_classII; cd01362 443150002890 active site 443150002891 tetramer interface [polypeptide binding]; other site 443150002892 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 443150002893 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 443150002894 putative active site [active] 443150002895 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 443150002896 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 443150002897 Domain of unknown function DUF20; Region: UPF0118; pfam01594 443150002898 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 443150002899 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 443150002900 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 443150002901 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 443150002902 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 443150002903 3beta-hydroxysteroid dehydrogenases (3b-HSD)-like, extended (e) SDRs; Region: 3b-HSD-like_SDR_e; cd05241 443150002904 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 443150002905 putative NAD(P) binding site [chemical binding]; other site 443150002906 active site 443150002907 putative substrate binding site [chemical binding]; other site 443150002908 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 443150002909 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 443150002910 generic binding surface II; other site 443150002911 generic binding surface I; other site 443150002912 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 443150002913 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 443150002914 Yip1 domain; Region: Yip1; pfam04893 443150002915 GTP-binding protein YchF; Reviewed; Region: PRK09601 443150002916 YchF GTPase; Region: YchF; cd01900 443150002917 G1 box; other site 443150002918 GTP/Mg2+ binding site [chemical binding]; other site 443150002919 Switch I region; other site 443150002920 G2 box; other site 443150002921 Switch II region; other site 443150002922 G3 box; other site 443150002923 G4 box; other site 443150002924 G5 box; other site 443150002925 Protein of unknown function (DUF933); Region: YchF-GTPase_C; pfam06071 443150002926 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487 443150002927 putative active site [active] 443150002928 Uncharacterized conserved protein [Function unknown]; Region: COG1359 443150002929 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 443150002930 cyclase homology domain; Region: CHD; cd07302 443150002931 nucleotidyl binding site; other site 443150002932 metal binding site [ion binding]; metal-binding site 443150002933 dimer interface [polypeptide binding]; other site 443150002934 glucose-6-phosphate 1-dehydrogenase; Region: zwf; TIGR00871 443150002935 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 443150002936 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 443150002937 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 443150002938 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd_rel; TIGR00872 443150002939 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443150002940 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443150002941 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443150002942 pyruvate phosphate dikinase; Provisional; Region: PRK05878 443150002943 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 443150002944 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 443150002945 Domain of unknown function (DUF222); Region: DUF222; pfam02720 443150002946 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 443150002947 active site 443150002948 Domain of unknown function (DUF222); Region: DUF222; pfam02720 443150002949 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 443150002950 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443150002951 non-specific DNA binding site [nucleotide binding]; other site 443150002952 salt bridge; other site 443150002953 sequence-specific DNA binding site [nucleotide binding]; other site 443150002954 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 443150002955 Domain of unknown function (DUF955); Region: DUF955; pfam06114 443150002956 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 443150002957 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 443150002958 citrate synthase; Provisional; Region: PRK14033 443150002959 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 443150002960 oxalacetate binding site [chemical binding]; other site 443150002961 citrylCoA binding site [chemical binding]; other site 443150002962 coenzyme A binding site [chemical binding]; other site 443150002963 catalytic triad [active] 443150002964 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 443150002965 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 443150002966 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 443150002967 THF binding site; other site 443150002968 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 443150002969 substrate binding site [chemical binding]; other site 443150002970 THF binding site; other site 443150002971 zinc-binding site [ion binding]; other site 443150002972 putative transposase OrfB; Reviewed; Region: PHA02517 443150002973 HTH-like domain; Region: HTH_21; pfam13276 443150002974 Integrase core domain; Region: rve; pfam00665 443150002975 Integrase core domain; Region: rve_3; pfam13683 443150002976 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150002977 PPE family; Region: PPE; pfam00823 443150002978 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443150002979 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 443150002980 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443150002981 substrate binding site [chemical binding]; other site 443150002982 oxyanion hole (OAH) forming residues; other site 443150002983 enoyl-CoA hydratase; Provisional; Region: PRK06494 443150002984 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 443150002985 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 443150002986 CAAX protease self-immunity; Region: Abi; pfam02517 443150002987 enoyl-CoA hydratase; Provisional; Region: PRK06688 443150002988 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 443150002989 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443150002990 trimer interface [polypeptide binding]; other site 443150002991 enoyl-CoA hydratase; Provisional; Region: PRK06688 443150002992 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443150002993 substrate binding site [chemical binding]; other site 443150002994 oxyanion hole (OAH) forming residues; other site 443150002995 trimer interface [polypeptide binding]; other site 443150002996 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 443150002997 CoA-transferase family III; Region: CoA_transf_3; pfam02515 443150002998 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 443150002999 NAD binding site [chemical binding]; other site 443150003000 homodimer interface [polypeptide binding]; other site 443150003001 homotetramer interface [polypeptide binding]; other site 443150003002 active site 443150003003 MMPL family; Region: MMPL; pfam03176 443150003004 MMPL family; Region: MMPL; pfam03176 443150003005 Domain of unknown function (DUF222); Region: DUF222; pfam02720 443150003006 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 443150003007 active site 443150003008 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 443150003009 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 443150003010 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 443150003011 NAD-dependent deacetylase; Provisional; Region: PRK00481 443150003012 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 443150003013 NAD+ binding site [chemical binding]; other site 443150003014 substrate binding site [chemical binding]; other site 443150003015 Zn binding site [ion binding]; other site 443150003016 Predicted transcriptional regulators [Transcription]; Region: COG1725 443150003017 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443150003018 DNA-binding site [nucleotide binding]; DNA binding site 443150003019 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 443150003020 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 443150003021 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 443150003022 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 443150003023 uncharacterized HhH-GPD family protein; Region: TIGR03252 443150003024 minor groove reading motif; other site 443150003025 helix-hairpin-helix signature motif; other site 443150003026 mannosyltransferase; Provisional; Region: pimE; PRK13375 443150003027 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 443150003028 active site 443150003029 8-oxo-dGMP binding site [chemical binding]; other site 443150003030 nudix motif; other site 443150003031 metal binding site [ion binding]; metal-binding site 443150003032 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 443150003033 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 443150003034 [4Fe-4S] binding site [ion binding]; other site 443150003035 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 443150003036 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 443150003037 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 443150003038 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 443150003039 molybdopterin cofactor binding site; other site 443150003040 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 443150003041 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 443150003042 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 443150003043 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 443150003044 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 443150003045 G1 box; other site 443150003046 putative GEF interaction site [polypeptide binding]; other site 443150003047 GTP/Mg2+ binding site [chemical binding]; other site 443150003048 Switch I region; other site 443150003049 G2 box; other site 443150003050 G3 box; other site 443150003051 Switch II region; other site 443150003052 G4 box; other site 443150003053 G5 box; other site 443150003054 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 443150003055 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 443150003056 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 443150003057 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 443150003058 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 443150003059 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443150003060 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443150003061 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150003062 PPE family; Region: PPE; pfam00823 443150003063 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 443150003064 PE family; Region: PE; pfam00934 443150003065 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 443150003066 PE family; Region: PE; pfam00934 443150003067 FO synthase; Reviewed; Region: fbiC; PRK09234 443150003068 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443150003069 FeS/SAM binding site; other site 443150003070 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443150003071 FeS/SAM binding site; other site 443150003072 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 443150003073 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 443150003074 active site 443150003075 FMN binding site [chemical binding]; other site 443150003076 2,4-decadienoyl-CoA binding site; other site 443150003077 catalytic residue [active] 443150003078 4Fe-4S cluster binding site [ion binding]; other site 443150003079 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 443150003080 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443150003081 Predicted transcriptional regulators [Transcription]; Region: COG1695 443150003082 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 443150003083 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 443150003084 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 443150003085 4Fe-4S binding domain; Region: Fer4; pfam00037 443150003086 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 443150003087 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443150003088 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443150003089 homodimer interface [polypeptide binding]; other site 443150003090 catalytic residue [active] 443150003091 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 443150003092 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 443150003093 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 443150003094 ATP binding site [chemical binding]; other site 443150003095 putative Mg++ binding site [ion binding]; other site 443150003096 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 443150003097 ATP-binding site [chemical binding]; other site 443150003098 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 443150003099 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 443150003100 active site 443150003101 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 443150003102 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 443150003103 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443150003104 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 443150003105 Enoylreductase; Region: PKS_ER; smart00829 443150003106 NAD(P) binding site [chemical binding]; other site 443150003107 KR domain; Region: KR; pfam08659 443150003108 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 443150003109 putative NADP binding site [chemical binding]; other site 443150003110 active site 443150003111 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 443150003112 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 443150003113 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 443150003114 PE-PPE domain; Region: PE-PPE; pfam08237 443150003115 acyl-CoA synthetase; Validated; Region: PRK05850 443150003116 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 443150003117 acyl-activating enzyme (AAE) consensus motif; other site 443150003118 active site 443150003119 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 443150003120 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 443150003121 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 443150003122 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 443150003123 Glutamate binding site [chemical binding]; other site 443150003124 NAD binding site [chemical binding]; other site 443150003125 catalytic residues [active] 443150003126 Proline dehydrogenase; Region: Pro_dh; pfam01619 443150003127 RNA polymerase sigma factor SigI; Provisional; Region: sigI; PRK09635 443150003128 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443150003129 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443150003130 DNA binding residues [nucleotide binding] 443150003131 haloalkane dehalogenase; Provisional; Region: PRK03204 443150003132 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 443150003133 catalytic site [active] 443150003134 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443150003135 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 443150003136 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443150003137 PGAP1-like protein; Region: PGAP1; pfam07819 443150003138 acyl-CoA synthetase; Validated; Region: PRK07787 443150003139 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443150003140 acyl-activating enzyme (AAE) consensus motif; other site 443150003141 AMP binding site [chemical binding]; other site 443150003142 active site 443150003143 CoA binding site [chemical binding]; other site 443150003144 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 443150003145 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 443150003146 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150003147 PPE family; Region: PPE; pfam00823 443150003148 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 443150003149 Transposase, Mutator family; Region: Transposase_mut; pfam00872 443150003150 MULE transposase domain; Region: MULE; pfam10551 443150003151 metabolite-proton symporter; Region: 2A0106; TIGR00883 443150003152 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443150003153 putative substrate translocation pore; other site 443150003154 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 443150003155 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 443150003156 putative trimer interface [polypeptide binding]; other site 443150003157 putative CoA binding site [chemical binding]; other site 443150003158 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 443150003159 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 443150003160 metal binding site [ion binding]; metal-binding site 443150003161 putative dimer interface [polypeptide binding]; other site 443150003162 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 443150003163 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 443150003164 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 443150003165 acyl-activating enzyme (AAE) consensus motif; other site 443150003166 putative AMP binding site [chemical binding]; other site 443150003167 putative active site [active] 443150003168 putative CoA binding site [chemical binding]; other site 443150003169 dihydropteroate synthase; Region: DHPS; TIGR01496 443150003170 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 443150003171 substrate binding pocket [chemical binding]; other site 443150003172 dimer interface [polypeptide binding]; other site 443150003173 inhibitor binding site; inhibition site 443150003174 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 443150003175 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 443150003176 DivIVA domain; Region: DivI1A_domain; TIGR03544 443150003177 DNA-3-methyladenine glycosylase I; Region: tag; TIGR00624 443150003178 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 443150003179 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 443150003180 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 443150003181 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 443150003182 ligand binding site; other site 443150003183 oligomer interface; other site 443150003184 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 443150003185 dimer interface [polypeptide binding]; other site 443150003186 N-terminal domain interface [polypeptide binding]; other site 443150003187 sulfate 1 binding site; other site 443150003188 PE family; Region: PE; pfam00934 443150003189 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 443150003190 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 443150003191 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 443150003192 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 443150003193 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 443150003194 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 443150003195 Walker A/P-loop; other site 443150003196 ATP binding site [chemical binding]; other site 443150003197 Q-loop/lid; other site 443150003198 ABC transporter signature motif; other site 443150003199 Walker B; other site 443150003200 D-loop; other site 443150003201 H-loop/switch region; other site 443150003202 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 443150003203 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443150003204 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 443150003205 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443150003206 S-adenosylmethionine binding site [chemical binding]; other site 443150003207 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 443150003208 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443150003209 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443150003210 DNA binding residues [nucleotide binding] 443150003211 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 443150003212 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 443150003213 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 443150003214 protein binding site [polypeptide binding]; other site 443150003215 sec-independent translocase; Provisional; Region: PRK03100 443150003216 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443150003217 Predicted membrane protein [Function unknown]; Region: COG3428 443150003218 Bacterial PH domain; Region: DUF304; pfam03703 443150003219 Uncharacterized conserved protein [Function unknown]; Region: COG3402 443150003220 Domain of unknown function DUF59; Region: DUF59; cl00941 443150003221 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 443150003222 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 443150003223 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 443150003224 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 443150003225 N-acetyl-D-glucosamine binding site [chemical binding]; other site 443150003226 catalytic residue [active] 443150003227 Predicted membrane protein [Function unknown]; Region: COG4420 443150003228 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 443150003229 MgtE intracellular N domain; Region: MgtE_N; smart00924 443150003230 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 443150003231 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 443150003232 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 443150003233 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443150003234 dimer interface [polypeptide binding]; other site 443150003235 conserved gate region; other site 443150003236 putative PBP binding loops; other site 443150003237 ABC-ATPase subunit interface; other site 443150003238 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 443150003239 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443150003240 dimer interface [polypeptide binding]; other site 443150003241 conserved gate region; other site 443150003242 ABC-ATPase subunit interface; other site 443150003243 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 443150003244 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 443150003245 Walker A/P-loop; other site 443150003246 ATP binding site [chemical binding]; other site 443150003247 Q-loop/lid; other site 443150003248 ABC transporter signature motif; other site 443150003249 Walker B; other site 443150003250 D-loop; other site 443150003251 H-loop/switch region; other site 443150003252 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 443150003253 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 443150003254 oligomer interface [polypeptide binding]; other site 443150003255 metal binding site [ion binding]; metal-binding site 443150003256 metal binding site [ion binding]; metal-binding site 443150003257 putative Cl binding site [ion binding]; other site 443150003258 basic sphincter; other site 443150003259 hydrophobic gate; other site 443150003260 periplasmic entrance; other site 443150003261 malate dehydrogenase; Provisional; Region: PRK05442 443150003262 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 443150003263 NAD(P) binding site [chemical binding]; other site 443150003264 dimer interface [polypeptide binding]; other site 443150003265 malate binding site [chemical binding]; other site 443150003266 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 443150003267 PE family; Region: PE; pfam00934 443150003268 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 443150003269 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 443150003270 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443150003271 NAD(P) binding site [chemical binding]; other site 443150003272 active site 443150003273 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 443150003274 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 443150003275 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 443150003276 TPP-binding site [chemical binding]; other site 443150003277 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 443150003278 dimer interface [polypeptide binding]; other site 443150003279 PYR/PP interface [polypeptide binding]; other site 443150003280 TPP binding site [chemical binding]; other site 443150003281 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 443150003282 RNase_H superfamily; Region: RNase_H_2; pfam13482 443150003283 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 443150003284 Part of AAA domain; Region: AAA_19; pfam13245 443150003285 AAA domain; Region: AAA_12; pfam13087 443150003286 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 443150003287 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 443150003288 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 443150003289 ATP binding site [chemical binding]; other site 443150003290 Mg++ binding site [ion binding]; other site 443150003291 motif III; other site 443150003292 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443150003293 nucleotide binding region [chemical binding]; other site 443150003294 ATP-binding site [chemical binding]; other site 443150003295 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 443150003296 putative RNA binding site [nucleotide binding]; other site 443150003297 Acyltransferase family; Region: Acyl_transf_3; pfam01757 443150003298 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443150003299 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443150003300 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443150003301 FAD binding domain; Region: FAD_binding_4; pfam01565 443150003302 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 443150003303 potential frameshift: common BLAST hit: gi|383307132|ref|YP_005359943.1| membrane transporter 443150003304 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443150003305 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443150003306 putative substrate translocation pore; other site 443150003307 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 443150003308 Fe-S cluster binding site [ion binding]; other site 443150003309 DNA binding site [nucleotide binding] 443150003310 active site 443150003311 hypothetical protein; Validated; Region: PRK05868 443150003312 hypothetical protein; Provisional; Region: PRK07236 443150003313 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 443150003314 Domain of unknown function (DUF385); Region: DUF385; pfam04075 443150003315 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 443150003316 HIT family signature motif; other site 443150003317 catalytic residue [active] 443150003318 amidase; Provisional; Region: PRK12470 443150003319 Amidase; Region: Amidase; pfam01425 443150003320 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 443150003321 cyclase homology domain; Region: CHD; cd07302 443150003322 nucleotidyl binding site; other site 443150003323 metal binding site [ion binding]; metal-binding site 443150003324 dimer interface [polypeptide binding]; other site 443150003325 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 443150003326 Catalytic domain of Protein Kinases; Region: PKc; cd00180 443150003327 active site 443150003328 ATP binding site [chemical binding]; other site 443150003329 substrate binding site [chemical binding]; other site 443150003330 activation loop (A-loop); other site 443150003331 PknH-like extracellular domain; Region: PknH_C; pfam14032 443150003332 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 443150003333 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 443150003334 DNA binding site [nucleotide binding] 443150003335 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 443150003336 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 443150003337 phosphopeptide binding site; other site 443150003338 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 443150003339 putative active site [active] 443150003340 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 443150003341 Protein of unknown function (DUF732); Region: DUF732; pfam05305 443150003342 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 443150003343 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 443150003344 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 443150003345 Walker A/P-loop; other site 443150003346 ATP binding site [chemical binding]; other site 443150003347 Q-loop/lid; other site 443150003348 ABC transporter signature motif; other site 443150003349 Walker B; other site 443150003350 D-loop; other site 443150003351 H-loop/switch region; other site 443150003352 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 443150003353 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 443150003354 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443150003355 Walker A/P-loop; other site 443150003356 ATP binding site [chemical binding]; other site 443150003357 Q-loop/lid; other site 443150003358 ABC transporter signature motif; other site 443150003359 Walker B; other site 443150003360 D-loop; other site 443150003361 H-loop/switch region; other site 443150003362 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 443150003363 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 443150003364 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 443150003365 catalytic core [active] 443150003366 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 443150003367 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 443150003368 active site 443150003369 metal binding site [ion binding]; metal-binding site 443150003370 DNA binding site [nucleotide binding] 443150003371 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443150003372 Walker A/P-loop; other site 443150003373 ATP binding site [chemical binding]; other site 443150003374 choline dehydrogenase; Validated; Region: PRK02106 443150003375 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 443150003376 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 443150003377 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 443150003378 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 443150003379 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 443150003380 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 443150003381 Walker A/P-loop; other site 443150003382 ATP binding site [chemical binding]; other site 443150003383 Q-loop/lid; other site 443150003384 ABC transporter signature motif; other site 443150003385 Walker B; other site 443150003386 D-loop; other site 443150003387 H-loop/switch region; other site 443150003388 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 443150003389 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 443150003390 Walker A/P-loop; other site 443150003391 ATP binding site [chemical binding]; other site 443150003392 Q-loop/lid; other site 443150003393 ABC transporter signature motif; other site 443150003394 Walker B; other site 443150003395 D-loop; other site 443150003396 H-loop/switch region; other site 443150003397 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 443150003398 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 443150003399 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443150003400 dimer interface [polypeptide binding]; other site 443150003401 conserved gate region; other site 443150003402 putative PBP binding loops; other site 443150003403 ABC-ATPase subunit interface; other site 443150003404 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 443150003405 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443150003406 dimer interface [polypeptide binding]; other site 443150003407 conserved gate region; other site 443150003408 putative PBP binding loops; other site 443150003409 ABC-ATPase subunit interface; other site 443150003410 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 443150003411 active site clefts [active] 443150003412 zinc binding site [ion binding]; other site 443150003413 dimer interface [polypeptide binding]; other site 443150003414 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 443150003415 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 443150003416 Active Sites [active] 443150003417 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 443150003418 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 443150003419 CysD dimerization site [polypeptide binding]; other site 443150003420 G1 box; other site 443150003421 putative GEF interaction site [polypeptide binding]; other site 443150003422 GTP/Mg2+ binding site [chemical binding]; other site 443150003423 Switch I region; other site 443150003424 G2 box; other site 443150003425 G3 box; other site 443150003426 Switch II region; other site 443150003427 G4 box; other site 443150003428 G5 box; other site 443150003429 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 443150003430 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 443150003431 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443150003432 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 443150003433 Walker A/P-loop; other site 443150003434 ligand-binding site [chemical binding]; other site 443150003435 ATP binding site [chemical binding]; other site 443150003436 Rrf2 family protein; Region: rrf2_super; TIGR00738 443150003437 Transcriptional regulator; Region: Rrf2; pfam02082 443150003438 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 443150003439 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 443150003440 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 443150003441 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 443150003442 Putative esterase; Region: Esterase; pfam00756 443150003443 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 443150003444 Predicted membrane protein [Function unknown]; Region: COG4325 443150003445 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 443150003446 Protein of unknown function (DUF732); Region: DUF732; pfam05305 443150003447 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 443150003448 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 443150003449 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 443150003450 active site 443150003451 HIGH motif; other site 443150003452 KMSK motif region; other site 443150003453 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 443150003454 tRNA binding surface [nucleotide binding]; other site 443150003455 anticodon binding site; other site 443150003456 diaminopimelate decarboxylase; Region: lysA; TIGR01048 443150003457 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 443150003458 active site 443150003459 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 443150003460 substrate binding site [chemical binding]; other site 443150003461 catalytic residues [active] 443150003462 dimer interface [polypeptide binding]; other site 443150003463 homoserine dehydrogenase; Provisional; Region: PRK06349 443150003464 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 443150003465 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 443150003466 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 443150003467 threonine synthase; Reviewed; Region: PRK06721 443150003468 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 443150003469 homodimer interface [polypeptide binding]; other site 443150003470 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443150003471 catalytic residue [active] 443150003472 Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083 443150003473 transcription termination factor Rho; Provisional; Region: PRK12678 443150003474 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 443150003475 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 443150003476 RNA binding site [nucleotide binding]; other site 443150003477 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 443150003478 multimer interface [polypeptide binding]; other site 443150003479 Walker A motif; other site 443150003480 ATP binding site [chemical binding]; other site 443150003481 Walker B motif; other site 443150003482 peptide chain release factor 1; Region: prfA; TIGR00019 443150003483 This domain is found in peptide chain release factors; Region: PCRF; smart00937 443150003484 RF-1 domain; Region: RF-1; pfam00472 443150003485 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 443150003486 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443150003487 S-adenosylmethionine binding site [chemical binding]; other site 443150003488 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 443150003489 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 443150003490 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 443150003491 Mg++ binding site [ion binding]; other site 443150003492 putative catalytic motif [active] 443150003493 substrate binding site [chemical binding]; other site 443150003494 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 443150003495 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 443150003496 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 443150003497 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 443150003498 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13428 443150003499 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 443150003500 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 443150003501 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 443150003502 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 443150003503 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 443150003504 Walker A motif; other site 443150003505 ATP binding site [chemical binding]; other site 443150003506 Walker B motif; other site 443150003507 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 443150003508 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 443150003509 core domain interface [polypeptide binding]; other site 443150003510 delta subunit interface [polypeptide binding]; other site 443150003511 epsilon subunit interface [polypeptide binding]; other site 443150003512 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 443150003513 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 443150003514 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 443150003515 alpha subunit interaction interface [polypeptide binding]; other site 443150003516 Walker A motif; other site 443150003517 ATP binding site [chemical binding]; other site 443150003518 Walker B motif; other site 443150003519 inhibitor binding site; inhibition site 443150003520 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 443150003521 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 443150003522 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 443150003523 gamma subunit interface [polypeptide binding]; other site 443150003524 epsilon subunit interface [polypeptide binding]; other site 443150003525 LBP interface [polypeptide binding]; other site 443150003526 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 443150003527 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 443150003528 Transposase; Region: DDE_Tnp_ISL3; pfam01610 443150003529 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 443150003530 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 443150003531 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 443150003532 hinge; other site 443150003533 active site 443150003534 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 443150003535 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 443150003536 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 443150003537 DNA binding site [nucleotide binding] 443150003538 active site 443150003539 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 443150003540 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 443150003541 AlkA N-terminal domain; Region: AlkA_N; pfam06029 443150003542 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 443150003543 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 443150003544 minor groove reading motif; other site 443150003545 helix-hairpin-helix signature motif; other site 443150003546 substrate binding pocket [chemical binding]; other site 443150003547 active site 443150003548 HAMP domain; Region: HAMP; pfam00672 443150003549 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 443150003550 cyclase homology domain; Region: CHD; cd07302 443150003551 nucleotidyl binding site; other site 443150003552 metal binding site [ion binding]; metal-binding site 443150003553 dimer interface [polypeptide binding]; other site 443150003554 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443150003555 dimerization interface [polypeptide binding]; other site 443150003556 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 443150003557 cyclase homology domain; Region: CHD; cd07302 443150003558 nucleotidyl binding site; other site 443150003559 metal binding site [ion binding]; metal-binding site 443150003560 dimer interface [polypeptide binding]; other site 443150003561 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443150003562 dimerization interface [polypeptide binding]; other site 443150003563 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 443150003564 cyclase homology domain; Region: CHD; cd07302 443150003565 nucleotidyl binding site; other site 443150003566 metal binding site [ion binding]; metal-binding site 443150003567 dimer interface [polypeptide binding]; other site 443150003568 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 443150003569 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443150003570 dimerization interface [polypeptide binding]; other site 443150003571 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 443150003572 cyclase homology domain; Region: CHD; cd07302 443150003573 nucleotidyl binding site; other site 443150003574 metal binding site [ion binding]; metal-binding site 443150003575 dimer interface [polypeptide binding]; other site 443150003576 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 443150003577 hypothetical protein; Provisional; Region: PRK03298 443150003578 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443150003579 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 443150003580 dimer interface [polypeptide binding]; other site 443150003581 substrate binding site [chemical binding]; other site 443150003582 metal binding site [ion binding]; metal-binding site 443150003583 putative acyltransferase; Provisional; Region: PRK05790 443150003584 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 443150003585 dimer interface [polypeptide binding]; other site 443150003586 active site 443150003587 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 443150003588 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 443150003589 PE family; Region: PE; pfam00934 443150003590 glycogen branching enzyme; Provisional; Region: PRK05402 443150003591 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 443150003592 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 443150003593 active site 443150003594 catalytic site [active] 443150003595 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 443150003596 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 443150003597 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 443150003598 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 443150003599 active site 443150003600 homodimer interface [polypeptide binding]; other site 443150003601 catalytic site [active] 443150003602 acceptor binding site [chemical binding]; other site 443150003603 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 443150003604 putative homodimer interface [polypeptide binding]; other site 443150003605 putative active site pocket [active] 443150003606 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 443150003607 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 443150003608 DEAD/DEAH box helicase; Region: DEAD; pfam00270 443150003609 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 443150003610 putative Mg++ binding site [ion binding]; other site 443150003611 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 443150003612 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 443150003613 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 443150003614 active site 443150003615 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 443150003616 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 443150003617 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 443150003618 putative active site pocket [active] 443150003619 cleavage site 443150003620 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 443150003621 MPN+ (JAMM) motif; other site 443150003622 Zinc-binding site [ion binding]; other site 443150003623 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 443150003624 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 443150003625 dimer interface [polypeptide binding]; other site 443150003626 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443150003627 catalytic residue [active] 443150003628 Rhomboid family; Region: Rhomboid; cl11446 443150003629 glutamate racemase; Provisional; Region: PRK00865 443150003630 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 443150003631 ribonuclease PH; Reviewed; Region: rph; PRK00173 443150003632 Ribonuclease PH; Region: RNase_PH_bact; cd11362 443150003633 hexamer interface [polypeptide binding]; other site 443150003634 active site 443150003635 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 443150003636 active site 443150003637 dimerization interface [polypeptide binding]; other site 443150003638 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 443150003639 Glucitol operon activator [Transcription]; Region: GutM; COG4578 443150003640 long-chain-fatty-acid--[acyl-carrier-protein] ligase; Validated; Region: PRK05851 443150003641 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 443150003642 acyl-activating enzyme (AAE) consensus motif; other site 443150003643 active site 443150003644 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443150003645 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443150003646 active site 443150003647 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 443150003648 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 443150003649 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 443150003650 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 443150003651 FAD binding pocket [chemical binding]; other site 443150003652 FAD binding motif [chemical binding]; other site 443150003653 phosphate binding motif [ion binding]; other site 443150003654 NAD binding pocket [chemical binding]; other site 443150003655 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443150003656 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 443150003657 Walker A/P-loop; other site 443150003658 ATP binding site [chemical binding]; other site 443150003659 Q-loop/lid; other site 443150003660 ABC transporter signature motif; other site 443150003661 Walker B; other site 443150003662 D-loop; other site 443150003663 H-loop/switch region; other site 443150003664 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443150003665 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 443150003666 Walker A/P-loop; other site 443150003667 ATP binding site [chemical binding]; other site 443150003668 Q-loop/lid; other site 443150003669 ABC transporter signature motif; other site 443150003670 Walker B; other site 443150003671 D-loop; other site 443150003672 H-loop/switch region; other site 443150003673 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 443150003674 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443150003675 NAD(P) binding site [chemical binding]; other site 443150003676 active site 443150003677 tetracycline repressor protein TetR; Provisional; Region: PRK13756 443150003678 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443150003679 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 443150003680 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 443150003681 GAF domain; Region: GAF; pfam01590 443150003682 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 443150003683 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 443150003684 metal binding site [ion binding]; metal-binding site 443150003685 active site 443150003686 I-site; other site 443150003687 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 443150003688 hypothetical protein; Provisional; Region: PRK07877 443150003689 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 443150003690 ATP binding site [chemical binding]; other site 443150003691 substrate interface [chemical binding]; other site 443150003692 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 443150003693 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 443150003694 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 443150003695 cyclase homology domain; Region: CHD; cd07302 443150003696 nucleotidyl binding site; other site 443150003697 dimer interface [polypeptide binding]; other site 443150003698 metal binding site [ion binding]; metal-binding site 443150003699 AAA ATPase domain; Region: AAA_16; pfam13191 443150003700 Predicted ATPase [General function prediction only]; Region: COG3903 443150003701 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443150003702 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443150003703 DNA binding residues [nucleotide binding] 443150003704 dimerization interface [polypeptide binding]; other site 443150003705 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 443150003706 cyclase homology domain; Region: CHD; cd07302 443150003707 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 443150003708 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 443150003709 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150003710 PPE family; Region: PPE; pfam00823 443150003711 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 443150003712 PAS fold; Region: PAS_4; pfam08448 443150003713 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443150003714 putative active site [active] 443150003715 heme pocket [chemical binding]; other site 443150003716 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 443150003717 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 443150003718 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 443150003719 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 443150003720 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 443150003721 anti sigma factor interaction site; other site 443150003722 regulatory phosphorylation site [posttranslational modification]; other site 443150003723 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 443150003724 anti sigma factor interaction site; other site 443150003725 regulatory phosphorylation site [posttranslational modification]; other site 443150003726 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 443150003727 synthetase active site [active] 443150003728 NTP binding site [chemical binding]; other site 443150003729 metal binding site [ion binding]; metal-binding site 443150003730 Beta-lactamase; Region: Beta-lactamase; pfam00144 443150003731 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 443150003732 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 443150003733 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; pfam00173 443150003734 putative transposase OrfB; Reviewed; Region: PHA02517 443150003735 HTH-like domain; Region: HTH_21; pfam13276 443150003736 Integrase core domain; Region: rve; pfam00665 443150003737 Integrase core domain; Region: rve_3; pfam13683 443150003738 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 443150003739 Transposase; Region: HTH_Tnp_1; cl17663 443150003740 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 443150003741 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 443150003742 malonyl-CoA binding site [chemical binding]; other site 443150003743 dimer interface [polypeptide binding]; other site 443150003744 active site 443150003745 product binding site; other site 443150003746 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 443150003747 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 443150003748 uncharacterized domain; Region: TIGR00702 443150003749 YcaO-like family; Region: YcaO; pfam02624 443150003750 Uncharacterized conserved protein [Function unknown]; Region: COG3482 443150003751 Domain of unknown function (DUF222); Region: DUF222; pfam02720 443150003752 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 443150003753 active site 443150003754 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 443150003755 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 443150003756 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 443150003757 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 443150003758 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 443150003759 dihydroorotase; Validated; Region: pyrC; PRK09357 443150003760 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 443150003761 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 443150003762 active site 443150003763 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 443150003764 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 443150003765 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 443150003766 catalytic site [active] 443150003767 subunit interface [polypeptide binding]; other site 443150003768 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 443150003769 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 443150003770 ATP-grasp domain; Region: ATP-grasp_4; cl17255 443150003771 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 443150003772 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 443150003773 ATP-grasp domain; Region: ATP-grasp_4; cl17255 443150003774 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 443150003775 IMP binding site; other site 443150003776 dimer interface [polypeptide binding]; other site 443150003777 interdomain contacts; other site 443150003778 partial ornithine binding site; other site 443150003779 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 443150003780 active site 443150003781 dimer interface [polypeptide binding]; other site 443150003782 PE family; Region: PE; pfam00934 443150003783 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150003784 PPE family; Region: PPE; pfam00823 443150003785 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 443150003786 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 443150003787 catalytic site [active] 443150003788 G-X2-G-X-G-K; other site 443150003789 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 443150003790 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 443150003791 Flavoprotein; Region: Flavoprotein; pfam02441 443150003792 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 443150003793 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 443150003794 S-adenosylmethionine synthetase; Validated; Region: PRK05250 443150003795 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 443150003796 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 443150003797 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 443150003798 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 443150003799 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443150003800 Cytochrome P450; Region: p450; cl12078 443150003801 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 443150003802 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 443150003803 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 443150003804 PE family; Region: PE; pfam00934 443150003805 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 443150003806 oligomeric interface; other site 443150003807 putative active site [active] 443150003808 homodimer interface [polypeptide binding]; other site 443150003809 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 443150003810 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 443150003811 substrate binding pocket [chemical binding]; other site 443150003812 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 443150003813 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 443150003814 substrate binding pocket [chemical binding]; other site 443150003815 Predicted membrane protein [Function unknown]; Region: COG3714 443150003816 primosome assembly protein PriA; Provisional; Region: PRK14873 443150003817 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443150003818 S-adenosylmethionine binding site [chemical binding]; other site 443150003819 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 443150003820 MarR family; Region: MarR; pfam01047 443150003821 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443150003822 S-adenosylmethionine binding site [chemical binding]; other site 443150003823 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 443150003824 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 443150003825 putative active site [active] 443150003826 substrate binding site [chemical binding]; other site 443150003827 putative cosubstrate binding site; other site 443150003828 catalytic site [active] 443150003829 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 443150003830 substrate binding site [chemical binding]; other site 443150003831 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 443150003832 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 443150003833 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 443150003834 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 443150003835 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 443150003836 substrate binding site [chemical binding]; other site 443150003837 hexamer interface [polypeptide binding]; other site 443150003838 metal binding site [ion binding]; metal-binding site 443150003839 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 443150003840 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 443150003841 catalytic motif [active] 443150003842 Zn binding site [ion binding]; other site 443150003843 RibD C-terminal domain; Region: RibD_C; pfam01872 443150003844 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 443150003845 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443150003846 putative substrate translocation pore; other site 443150003847 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 443150003848 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 443150003849 Lumazine binding domain; Region: Lum_binding; pfam00677 443150003850 Lumazine binding domain; Region: Lum_binding; pfam00677 443150003851 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 443150003852 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 443150003853 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 443150003854 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 443150003855 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 443150003856 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 443150003857 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 443150003858 dimerization interface [polypeptide binding]; other site 443150003859 active site 443150003860 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 443150003861 homopentamer interface [polypeptide binding]; other site 443150003862 active site 443150003863 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 443150003864 PknH-like extracellular domain; Region: PknH_C; pfam14032 443150003865 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 443150003866 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 443150003867 putative sugar binding sites [chemical binding]; other site 443150003868 Q-X-W motif; other site 443150003869 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 443150003870 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 443150003871 active site 443150003872 GIY-YIG motif/motif A; other site 443150003873 catalytic site [active] 443150003874 putative DNA binding site [nucleotide binding]; other site 443150003875 metal binding site [ion binding]; metal-binding site 443150003876 UvrB/uvrC motif; Region: UVR; pfam02151 443150003877 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 443150003878 Helix-hairpin-helix motif; Region: HHH; pfam00633 443150003879 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 443150003880 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 443150003881 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 443150003882 phosphate binding site [ion binding]; other site 443150003883 putative substrate binding pocket [chemical binding]; other site 443150003884 dimer interface [polypeptide binding]; other site 443150003885 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 443150003886 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 443150003887 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443150003888 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443150003889 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 443150003890 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 443150003891 acyl-CoA synthetase; Provisional; Region: PRK13382 443150003892 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 443150003893 acyl-activating enzyme (AAE) consensus motif; other site 443150003894 putative AMP binding site [chemical binding]; other site 443150003895 putative active site [active] 443150003896 putative CoA binding site [chemical binding]; other site 443150003897 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 443150003898 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 443150003899 putative acyl-acceptor binding pocket; other site 443150003900 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 443150003901 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 443150003902 PE family; Region: PE; pfam00934 443150003903 PE-PPE domain; Region: PE-PPE; pfam08237 443150003904 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 443150003905 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 443150003906 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 443150003907 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 443150003908 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 443150003909 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 443150003910 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 443150003911 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 443150003912 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 443150003913 Phosphoglycerate kinase; Region: PGK; pfam00162 443150003914 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 443150003915 substrate binding site [chemical binding]; other site 443150003916 hinge regions; other site 443150003917 ADP binding site [chemical binding]; other site 443150003918 catalytic site [active] 443150003919 triosephosphate isomerase; Provisional; Region: PRK14567 443150003920 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 443150003921 substrate binding site [chemical binding]; other site 443150003922 dimer interface [polypeptide binding]; other site 443150003923 catalytic triad [active] 443150003924 SnoaL-like domain; Region: SnoaL_2; pfam12680 443150003925 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 443150003926 PE family; Region: PE; pfam00934 443150003927 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 443150003928 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 443150003929 molybdopterin cofactor binding site [chemical binding]; other site 443150003930 substrate binding site [chemical binding]; other site 443150003931 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 443150003932 molybdopterin cofactor binding site; other site 443150003933 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 443150003934 hydrophobic ligand binding site; other site 443150003935 Proteins of 100 residues with WXG; Region: WXG100; cl02005 443150003936 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 443150003937 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 443150003938 putative active site [active] 443150003939 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 443150003940 Glucose-6-P dehydrogenase subunit [Carbohydrate transport and metabolism]; Region: COG3429 443150003941 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 443150003942 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 443150003943 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 443150003944 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 443150003945 putative active site [active] 443150003946 transaldolase; Provisional; Region: PRK03903 443150003947 catalytic residue [active] 443150003948 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 443150003949 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 443150003950 TPP-binding site [chemical binding]; other site 443150003951 dimer interface [polypeptide binding]; other site 443150003952 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 443150003953 PYR/PP interface [polypeptide binding]; other site 443150003954 dimer interface [polypeptide binding]; other site 443150003955 TPP binding site [chemical binding]; other site 443150003956 PE family; Region: PE; pfam00934 443150003957 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 443150003958 UbiA prenyltransferase family; Region: UbiA; pfam01040 443150003959 PE family; Region: PE; pfam00934 443150003960 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 443150003961 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 443150003962 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 443150003963 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 443150003964 NADP binding site [chemical binding]; other site 443150003965 dimer interface [polypeptide binding]; other site 443150003966 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 443150003967 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 443150003968 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 443150003969 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 443150003970 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 443150003971 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 443150003972 Walker A/P-loop; other site 443150003973 ATP binding site [chemical binding]; other site 443150003974 Q-loop/lid; other site 443150003975 ABC transporter signature motif; other site 443150003976 Walker B; other site 443150003977 D-loop; other site 443150003978 H-loop/switch region; other site 443150003979 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 443150003980 iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702 443150003981 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 443150003982 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 443150003983 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 443150003984 protein-splicing catalytic site; other site 443150003985 thioester formation/cholesterol transfer; other site 443150003986 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 443150003987 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 443150003988 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 443150003989 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 443150003990 FeS assembly protein SufD; Region: sufD; TIGR01981 443150003991 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 443150003992 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 443150003993 Walker A/P-loop; other site 443150003994 ATP binding site [chemical binding]; other site 443150003995 Q-loop/lid; other site 443150003996 ABC transporter signature motif; other site 443150003997 Walker B; other site 443150003998 D-loop; other site 443150003999 H-loop/switch region; other site 443150004000 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 443150004001 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 443150004002 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443150004003 catalytic residue [active] 443150004004 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 443150004005 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 443150004006 trimerization site [polypeptide binding]; other site 443150004007 active site 443150004008 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 443150004009 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 443150004010 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 443150004011 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443150004012 active site 443150004013 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 443150004014 PE family; Region: PE; pfam00934 443150004015 putative transposase OrfB; Reviewed; Region: PHA02517 443150004016 HTH-like domain; Region: HTH_21; pfam13276 443150004017 Integrase core domain; Region: rve; pfam00665 443150004018 Integrase core domain; Region: rve_3; pfam13683 443150004019 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 443150004020 Transposase; Region: HTH_Tnp_1; cl17663 443150004021 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 443150004022 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 443150004023 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 443150004024 catalytic residues [active] 443150004025 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 443150004026 catalytic residues [active] 443150004027 enoyl-CoA hydratase; Provisional; Region: PRK05864 443150004028 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443150004029 substrate binding site [chemical binding]; other site 443150004030 oxyanion hole (OAH) forming residues; other site 443150004031 trimer interface [polypeptide binding]; other site 443150004032 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 443150004033 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443150004034 Walker A/P-loop; other site 443150004035 ATP binding site [chemical binding]; other site 443150004036 Q-loop/lid; other site 443150004037 ABC transporter signature motif; other site 443150004038 Walker B; other site 443150004039 D-loop; other site 443150004040 H-loop/switch region; other site 443150004041 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 443150004042 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443150004043 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443150004044 aconitate hydratase; Validated; Region: PRK09277 443150004045 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 443150004046 substrate binding site [chemical binding]; other site 443150004047 ligand binding site [chemical binding]; other site 443150004048 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 443150004049 substrate binding site [chemical binding]; other site 443150004050 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 443150004051 NlpC/P60 family; Region: NLPC_P60; pfam00877 443150004052 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 443150004053 NlpC/P60 family; Region: NLPC_P60; pfam00877 443150004054 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443150004055 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 443150004056 Walker A motif; other site 443150004057 ATP binding site [chemical binding]; other site 443150004058 Walker B motif; other site 443150004059 arginine finger; other site 443150004060 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 443150004061 Protein of unknown function DUF58; Region: DUF58; pfam01882 443150004062 hypothetical protein; Provisional; Region: PRK13685 443150004063 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 443150004064 metal ion-dependent adhesion site (MIDAS); other site 443150004065 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 443150004066 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443150004067 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 443150004068 NAD(P) binding site [chemical binding]; other site 443150004069 active site 443150004070 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 443150004071 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 443150004072 NAD binding site [chemical binding]; other site 443150004073 homotetramer interface [polypeptide binding]; other site 443150004074 homodimer interface [polypeptide binding]; other site 443150004075 substrate binding site [chemical binding]; other site 443150004076 active site 443150004077 ferrochelatase; Reviewed; Region: hemH; PRK00035 443150004078 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 443150004079 C-terminal domain interface [polypeptide binding]; other site 443150004080 active site 443150004081 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 443150004082 active site 443150004083 N-terminal domain interface [polypeptide binding]; other site 443150004084 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 443150004085 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 443150004086 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 443150004087 Uncharacterized conserved protein [Function unknown]; Region: COG0398 443150004088 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 443150004089 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 443150004090 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 443150004091 heterodimer interface [polypeptide binding]; other site 443150004092 substrate interaction site [chemical binding]; other site 443150004093 Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding) [Lipid metabolism]; Region: Sbm; COG2185 443150004094 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 443150004095 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 443150004096 active site 443150004097 substrate binding site [chemical binding]; other site 443150004098 coenzyme B12 binding site [chemical binding]; other site 443150004099 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 443150004100 B12 binding site [chemical binding]; other site 443150004101 cobalt ligand [ion binding]; other site 443150004102 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 443150004103 membrane ATPase/protein kinase; Provisional; Region: PRK09435 443150004104 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 443150004105 Walker A; other site 443150004106 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 443150004107 Beta-lactamase; Region: Beta-lactamase; pfam00144 443150004108 Methyltransferase domain; Region: Methyltransf_31; pfam13847 443150004109 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443150004110 S-adenosylmethionine binding site [chemical binding]; other site 443150004111 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 443150004112 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 443150004113 Ligand binding site; other site 443150004114 Putative Catalytic site; other site 443150004115 DXD motif; other site 443150004116 Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5285 443150004117 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 443150004118 active site 443150004119 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 443150004120 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 443150004121 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443150004122 catalytic residue [active] 443150004123 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 443150004124 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 443150004125 putative trimer interface [polypeptide binding]; other site 443150004126 putative CoA binding site [chemical binding]; other site 443150004127 WbqC-like protein family; Region: WbqC; pfam08889 443150004128 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 443150004129 Methyltransferase domain; Region: Methyltransf_23; pfam13489 443150004130 Methyltransferase domain; Region: Methyltransf_12; pfam08242 443150004131 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 443150004132 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 443150004133 NADP-binding site; other site 443150004134 homotetramer interface [polypeptide binding]; other site 443150004135 substrate binding site [chemical binding]; other site 443150004136 homodimer interface [polypeptide binding]; other site 443150004137 active site 443150004138 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 443150004139 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 443150004140 NADP binding site [chemical binding]; other site 443150004141 active site 443150004142 putative substrate binding site [chemical binding]; other site 443150004143 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 443150004144 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 443150004145 metal-binding site 443150004146 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443150004147 S-adenosylmethionine binding site [chemical binding]; other site 443150004148 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 443150004149 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 443150004150 active site 443150004151 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 443150004152 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 443150004153 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 443150004154 active site 443150004155 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 443150004156 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 443150004157 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 443150004158 active site 443150004159 acyl-CoA synthetase; Validated; Region: PRK05850 443150004160 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 443150004161 acyl-activating enzyme (AAE) consensus motif; other site 443150004162 active site 443150004163 Transport protein; Region: actII; TIGR00833 443150004164 Methyltransferase domain; Region: Methyltransf_23; pfam13489 443150004165 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443150004166 S-adenosylmethionine binding site [chemical binding]; other site 443150004167 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 443150004168 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 443150004169 homodimer interface [polypeptide binding]; other site 443150004170 active site 443150004171 TDP-binding site; other site 443150004172 acceptor substrate-binding pocket; other site 443150004173 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 443150004174 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 443150004175 Probable Catalytic site; other site 443150004176 metal-binding site 443150004177 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 443150004178 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 443150004179 homodimer interface [polypeptide binding]; other site 443150004180 active site 443150004181 TDP-binding site; other site 443150004182 acceptor substrate-binding pocket; other site 443150004183 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 443150004184 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 443150004185 active site 443150004186 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 443150004187 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 443150004188 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443150004189 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 443150004190 Enoylreductase; Region: PKS_ER; smart00829 443150004191 NAD(P) binding site [chemical binding]; other site 443150004192 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 443150004193 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 443150004194 putative NADP binding site [chemical binding]; other site 443150004195 active site 443150004196 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 443150004197 acyl-CoA synthetase; Validated; Region: PRK05850 443150004198 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 443150004199 acyl-activating enzyme (AAE) consensus motif; other site 443150004200 active site 443150004201 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 443150004202 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 443150004203 NAD(P) binding site [chemical binding]; other site 443150004204 Uncharacterized conserved protein [Function unknown]; Region: COG2128 443150004205 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 443150004206 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 443150004207 CoenzymeA binding site [chemical binding]; other site 443150004208 subunit interaction site [polypeptide binding]; other site 443150004209 PHB binding site; other site 443150004210 Nitronate monooxygenase; Region: NMO; pfam03060 443150004211 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 443150004212 FMN binding site [chemical binding]; other site 443150004213 substrate binding site [chemical binding]; other site 443150004214 putative catalytic residue [active] 443150004215 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443150004216 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 443150004217 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 443150004218 HIGH motif; other site 443150004219 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 443150004220 active site 443150004221 KMSKS motif; other site 443150004222 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 443150004223 tRNA binding surface [nucleotide binding]; other site 443150004224 anticodon binding site; other site 443150004225 DNA polymerase IV; Provisional; Region: PRK03348 443150004226 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 443150004227 active site 443150004228 DNA binding site [nucleotide binding] 443150004229 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 443150004230 active site 443150004231 homodimer interface [polypeptide binding]; other site 443150004232 homotetramer interface [polypeptide binding]; other site 443150004233 lipoprotein signal peptidase; Provisional; Region: PRK14764 443150004234 lipoprotein signal peptidase; Provisional; Region: PRK14787 443150004235 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 443150004236 active site 443150004237 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 443150004238 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 443150004239 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 443150004240 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 443150004241 apolar tunnel; other site 443150004242 heme binding site [chemical binding]; other site 443150004243 dimerization interface [polypeptide binding]; other site 443150004244 short chain dehydrogenase; Provisional; Region: PRK05866 443150004245 classical (c) SDRs; Region: SDR_c; cd05233 443150004246 NAD(P) binding site [chemical binding]; other site 443150004247 active site 443150004248 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 443150004249 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443150004250 NAD(P) binding site [chemical binding]; other site 443150004251 active site 443150004252 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 443150004253 hydrophobic ligand binding site; other site 443150004254 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 443150004255 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 443150004256 active site 443150004257 PHP Thumb interface [polypeptide binding]; other site 443150004258 metal binding site [ion binding]; metal-binding site 443150004259 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 443150004260 generic binding surface II; other site 443150004261 generic binding surface I; other site 443150004262 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150004263 PPE family; Region: PPE; pfam00823 443150004264 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443150004265 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443150004266 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443150004267 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 443150004268 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 443150004269 acyl-activating enzyme (AAE) consensus motif; other site 443150004270 putative AMP binding site [chemical binding]; other site 443150004271 putative active site [active] 443150004272 putative CoA binding site [chemical binding]; other site 443150004273 potential frameshift: common BLAST hit: gi|383307406|ref|YP_005360217.1| glycerol-3-phosphate acyltransferase 443150004274 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 443150004275 putative acyl-acceptor binding pocket; other site 443150004276 glycerol-3-phosphate acyltransferase; Reviewed; Region: PRK11915 443150004277 fumarate reductase, flavoprotein subunit; Region: fum_red_Fp; TIGR01176 443150004278 L-aspartate oxidase; Provisional; Region: PRK06175 443150004279 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 443150004280 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 443150004281 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 443150004282 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 443150004283 D-subunit interface [polypeptide binding]; other site 443150004284 Iron-sulfur protein interface; other site 443150004285 proximal quinone binding site [chemical binding]; other site 443150004286 distal quinone binding site [chemical binding]; other site 443150004287 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 443150004288 Iron-sulfur protein interface; other site 443150004289 proximal quinone binding site [chemical binding]; other site 443150004290 C-subunit interface; other site 443150004291 distal quinone binding site; other site 443150004292 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443150004293 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443150004294 MMPL family; Region: MMPL; pfam03176 443150004295 Domain of unknown function (DUF385); Region: DUF385; pfam04075 443150004296 threonine dehydratase; Validated; Region: PRK08639 443150004297 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 443150004298 tetramer interface [polypeptide binding]; other site 443150004299 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443150004300 catalytic residue [active] 443150004301 C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585 443150004302 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 443150004303 putative active site [active] 443150004304 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 443150004305 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 443150004306 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 443150004307 catalytic site [active] 443150004308 active site 443150004309 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 443150004310 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 443150004311 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 443150004312 active site 443150004313 catalytic site [active] 443150004314 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 443150004315 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 443150004316 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 443150004317 active site 443150004318 catalytic site [active] 443150004319 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 443150004320 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 443150004321 NlpC/P60 family; Region: NLPC_P60; pfam00877 443150004322 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 443150004323 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 443150004324 inhibitor-cofactor binding pocket; inhibition site 443150004325 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443150004326 catalytic residue [active] 443150004327 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 443150004328 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 443150004329 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443150004330 catalytic residue [active] 443150004331 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 443150004332 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 443150004333 Domain of unknown function (DUF222); Region: DUF222; pfam02720 443150004334 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 443150004335 active site 443150004336 biotin synthase; Validated; Region: PRK06256 443150004337 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443150004338 FeS/SAM binding site; other site 443150004339 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 443150004340 Protein of unknown function (DUF2567); Region: DUF2567; pfam10821 443150004341 Secretory lipase; Region: LIP; pfam03583 443150004342 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 443150004343 nudix motif; other site 443150004344 quinolinate synthetase; Provisional; Region: PRK09375 443150004345 L-aspartate oxidase; Provisional; Region: PRK07804 443150004346 L-aspartate oxidase; Provisional; Region: PRK06175 443150004347 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 443150004348 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 443150004349 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 443150004350 dimerization interface [polypeptide binding]; other site 443150004351 active site 443150004352 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443150004353 S-adenosylmethionine binding site [chemical binding]; other site 443150004354 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 443150004355 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 443150004356 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 443150004357 NAD binding site [chemical binding]; other site 443150004358 dimerization interface [polypeptide binding]; other site 443150004359 product binding site; other site 443150004360 substrate binding site [chemical binding]; other site 443150004361 zinc binding site [ion binding]; other site 443150004362 catalytic residues [active] 443150004363 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 443150004364 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443150004365 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443150004366 homodimer interface [polypeptide binding]; other site 443150004367 catalytic residue [active] 443150004368 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 443150004369 4-fold oligomerization interface [polypeptide binding]; other site 443150004370 putative active site pocket [active] 443150004371 metal binding residues [ion binding]; metal-binding site 443150004372 3-fold/trimer interface [polypeptide binding]; other site 443150004373 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 443150004374 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 443150004375 putative active site [active] 443150004376 oxyanion strand; other site 443150004377 catalytic triad [active] 443150004378 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 443150004379 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 443150004380 catalytic residues [active] 443150004381 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 443150004382 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 443150004383 active site 443150004384 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 443150004385 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 443150004386 substrate binding site [chemical binding]; other site 443150004387 glutamase interaction surface [polypeptide binding]; other site 443150004388 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 443150004389 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 443150004390 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 443150004391 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 443150004392 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 443150004393 catalytic triad [active] 443150004394 anthranilate synthase component I; Provisional; Region: PRK13571 443150004395 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 443150004396 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 443150004397 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 443150004398 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 443150004399 active site 443150004400 ribulose/triose binding site [chemical binding]; other site 443150004401 phosphate binding site [ion binding]; other site 443150004402 substrate (anthranilate) binding pocket [chemical binding]; other site 443150004403 product (indole) binding pocket [chemical binding]; other site 443150004404 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 443150004405 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 443150004406 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443150004407 catalytic residue [active] 443150004408 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 443150004409 substrate binding site [chemical binding]; other site 443150004410 active site 443150004411 catalytic residues [active] 443150004412 heterodimer interface [polypeptide binding]; other site 443150004413 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108 443150004414 Prolipoprotein diacylglyceryltransferase [Cell envelope biogenesis, outer membrane]; Region: Lgt; COG0682 443150004415 TM2 domain; Region: TM2; pfam05154 443150004416 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 443150004417 pyruvate kinase; Provisional; Region: PRK06247 443150004418 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 443150004419 domain interfaces; other site 443150004420 active site 443150004421 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 443150004422 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 443150004423 active site 443150004424 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 443150004425 catalytic triad [active] 443150004426 dimer interface [polypeptide binding]; other site 443150004427 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 443150004428 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443150004429 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 443150004430 Walker A/P-loop; other site 443150004431 Walker A/P-loop; other site 443150004432 ATP binding site [chemical binding]; other site 443150004433 ATP binding site [chemical binding]; other site 443150004434 Q-loop/lid; other site 443150004435 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 443150004436 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443150004437 Walker A/P-loop; other site 443150004438 ATP binding site [chemical binding]; other site 443150004439 Q-loop/lid; other site 443150004440 ABC transporter signature motif; other site 443150004441 Walker B; other site 443150004442 D-loop; other site 443150004443 H-loop/switch region; other site 443150004444 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 443150004445 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 443150004446 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 443150004447 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 443150004448 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 443150004449 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 443150004450 cyclase homology domain; Region: CHD; cd07302 443150004451 nucleotidyl binding site; other site 443150004452 metal binding site [ion binding]; metal-binding site 443150004453 dimer interface [polypeptide binding]; other site 443150004454 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 443150004455 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443150004456 active site 443150004457 phosphorylation site [posttranslational modification] 443150004458 intermolecular recognition site; other site 443150004459 dimerization interface [polypeptide binding]; other site 443150004460 ANTAR domain; Region: ANTAR; pfam03861 443150004461 lipid-transfer protein; Provisional; Region: PRK06059 443150004462 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 443150004463 active site 443150004464 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 443150004465 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 443150004466 DUF35 OB-fold domain; Region: DUF35; pfam01796 443150004467 DNA polymerase I; Provisional; Region: PRK05755 443150004468 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 443150004469 active site 443150004470 metal binding site 1 [ion binding]; metal-binding site 443150004471 putative 5' ssDNA interaction site; other site 443150004472 metal binding site 3; metal-binding site 443150004473 metal binding site 2 [ion binding]; metal-binding site 443150004474 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 443150004475 putative DNA binding site [nucleotide binding]; other site 443150004476 putative metal binding site [ion binding]; other site 443150004477 3'-5' exonuclease; Region: 35EXOc; smart00474 443150004478 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 443150004479 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 443150004480 active site 443150004481 DNA binding site [nucleotide binding] 443150004482 catalytic site [active] 443150004483 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 443150004484 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 443150004485 RNA binding site [nucleotide binding]; other site 443150004486 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 443150004487 RNA binding site [nucleotide binding]; other site 443150004488 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 443150004489 RNA binding site [nucleotide binding]; other site 443150004490 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 443150004491 RNA binding site [nucleotide binding]; other site 443150004492 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 443150004493 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 443150004494 CoA-binding site [chemical binding]; other site 443150004495 ATP-binding [chemical binding]; other site 443150004496 Uncharacterized conserved protein [Function unknown]; Region: GrpB; COG2320 443150004497 Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306 443150004498 excinuclease ABC subunit B; Provisional; Region: PRK05298 443150004499 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443150004500 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443150004501 nucleotide binding region [chemical binding]; other site 443150004502 ATP-binding site [chemical binding]; other site 443150004503 Ultra-violet resistance protein B; Region: UvrB; pfam12344 443150004504 UvrB/uvrC motif; Region: UVR; pfam02151 443150004505 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443150004506 Major Facilitator Superfamily; Region: MFS_1; pfam07690 443150004507 putative substrate translocation pore; other site 443150004508 Predicted membrane protein [Function unknown]; Region: COG5305 443150004509 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 443150004510 Ligand Binding Site [chemical binding]; other site 443150004511 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 443150004512 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 443150004513 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 443150004514 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 443150004515 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 443150004516 Predicted esterase [General function prediction only]; Region: COG0627 443150004517 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 443150004518 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 443150004519 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 443150004520 dimer interface [polypeptide binding]; other site 443150004521 putative anticodon binding site; other site 443150004522 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 443150004523 motif 1; other site 443150004524 dimer interface [polypeptide binding]; other site 443150004525 active site 443150004526 motif 2; other site 443150004527 motif 3; other site 443150004528 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 443150004529 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 443150004530 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 443150004531 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 443150004532 23S rRNA binding site [nucleotide binding]; other site 443150004533 L21 binding site [polypeptide binding]; other site 443150004534 L13 binding site [polypeptide binding]; other site 443150004535 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 443150004536 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 443150004537 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 443150004538 PE family; Region: PE; pfam00934 443150004539 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 443150004540 cyclase homology domain; Region: CHD; cd07302 443150004541 nucleotidyl binding site; other site 443150004542 metal binding site [ion binding]; metal-binding site 443150004543 dimer interface [polypeptide binding]; other site 443150004544 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 443150004545 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 443150004546 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 443150004547 dimer interface [polypeptide binding]; other site 443150004548 motif 1; other site 443150004549 active site 443150004550 motif 2; other site 443150004551 motif 3; other site 443150004552 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 443150004553 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 443150004554 putative tRNA-binding site [nucleotide binding]; other site 443150004555 B3/4 domain; Region: B3_4; pfam03483 443150004556 tRNA synthetase B5 domain; Region: B5; smart00874 443150004557 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 443150004558 dimer interface [polypeptide binding]; other site 443150004559 motif 1; other site 443150004560 motif 3; other site 443150004561 motif 2; other site 443150004562 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 443150004563 PE family; Region: PE; pfam00934 443150004564 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 443150004565 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 443150004566 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 443150004567 heterotetramer interface [polypeptide binding]; other site 443150004568 active site pocket [active] 443150004569 cleavage site 443150004570 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 443150004571 feedback inhibition sensing region; other site 443150004572 homohexameric interface [polypeptide binding]; other site 443150004573 nucleotide binding site [chemical binding]; other site 443150004574 N-acetyl-L-glutamate binding site [chemical binding]; other site 443150004575 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 443150004576 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 443150004577 inhibitor-cofactor binding pocket; inhibition site 443150004578 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443150004579 catalytic residue [active] 443150004580 ornithine carbamoyltransferase; Provisional; Region: PRK00779 443150004581 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 443150004582 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 443150004583 arginine repressor; Provisional; Region: PRK03341 443150004584 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 443150004585 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 443150004586 argininosuccinate synthase; Provisional; Region: PRK13820 443150004587 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 443150004588 ANP binding site [chemical binding]; other site 443150004589 Substrate Binding Site II [chemical binding]; other site 443150004590 Substrate Binding Site I [chemical binding]; other site 443150004591 argininosuccinate lyase; Provisional; Region: PRK00855 443150004592 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 443150004593 active sites [active] 443150004594 tetramer interface [polypeptide binding]; other site 443150004595 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 443150004596 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 443150004597 malonyl-CoA binding site [chemical binding]; other site 443150004598 dimer interface [polypeptide binding]; other site 443150004599 active site 443150004600 product binding site; other site 443150004601 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 443150004602 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 443150004603 active site 443150004604 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 443150004605 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 443150004606 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443150004607 Enoylreductase; Region: PKS_ER; smart00829 443150004608 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 443150004609 NAD(P) binding site [chemical binding]; other site 443150004610 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 443150004611 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 443150004612 putative NADP binding site [chemical binding]; other site 443150004613 active site 443150004614 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 443150004615 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 443150004616 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 443150004617 active site 443150004618 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 443150004619 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 443150004620 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443150004621 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 443150004622 Enoylreductase; Region: PKS_ER; smart00829 443150004623 NAD(P) binding site [chemical binding]; other site 443150004624 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 443150004625 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 443150004626 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 443150004627 putative NADP binding site [chemical binding]; other site 443150004628 active site 443150004629 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 443150004630 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 443150004631 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 443150004632 active site 443150004633 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 443150004634 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 443150004635 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 443150004636 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 443150004637 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 443150004638 malonyl-CoA binding site [chemical binding]; other site 443150004639 dimer interface [polypeptide binding]; other site 443150004640 active site 443150004641 product binding site; other site 443150004642 Cytochrome P450; Region: p450; cl12078 443150004643 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443150004644 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 443150004645 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 443150004646 ABC transporter; Region: ABC_tran_2; pfam12848 443150004647 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 443150004648 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 443150004649 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443150004650 putative substrate translocation pore; other site 443150004651 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 443150004652 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 443150004653 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443150004654 dimerization interface [polypeptide binding]; other site 443150004655 putative DNA binding site [nucleotide binding]; other site 443150004656 putative Zn2+ binding site [ion binding]; other site 443150004657 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 443150004658 active site residue [active] 443150004659 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 443150004660 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 443150004661 ligand binding site [chemical binding]; other site 443150004662 flexible hinge region; other site 443150004663 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 443150004664 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 443150004665 putative catalytic residues [active] 443150004666 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 443150004667 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 443150004668 catalytic residues [active] 443150004669 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443150004670 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443150004671 active site 443150004672 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 443150004673 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 443150004674 substrate binding pocket [chemical binding]; other site 443150004675 membrane-bound complex binding site; other site 443150004676 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 443150004677 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443150004678 FeS/SAM binding site; other site 443150004679 DivIVA protein; Region: DivIVA; pfam05103 443150004680 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 443150004681 acyl-CoA synthetase; Validated; Region: PRK07868 443150004682 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 443150004683 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443150004684 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443150004685 acyl-activating enzyme (AAE) consensus motif; other site 443150004686 AMP binding site [chemical binding]; other site 443150004687 active site 443150004688 CoA binding site [chemical binding]; other site 443150004689 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443150004690 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 443150004691 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 443150004692 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 443150004693 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 443150004694 Walker A/P-loop; other site 443150004695 ATP binding site [chemical binding]; other site 443150004696 Q-loop/lid; other site 443150004697 ABC transporter signature motif; other site 443150004698 Walker B; other site 443150004699 D-loop; other site 443150004700 H-loop/switch region; other site 443150004701 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 443150004702 active site 443150004703 DNA binding site [nucleotide binding] 443150004704 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 443150004705 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 443150004706 active site 443150004707 HIGH motif; other site 443150004708 dimer interface [polypeptide binding]; other site 443150004709 KMSKS motif; other site 443150004710 S4 RNA-binding domain; Region: S4; smart00363 443150004711 RNA binding surface [nucleotide binding]; other site 443150004712 Protein of unknown function (DUF732); Region: DUF732; pfam05305 443150004713 Tetratrico peptide repeat; Region: TPR_5; pfam12688 443150004714 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 443150004715 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 443150004716 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 443150004717 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 443150004718 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 443150004719 RNA binding surface [nucleotide binding]; other site 443150004720 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443150004721 S-adenosylmethionine binding site [chemical binding]; other site 443150004722 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 443150004723 ATP-NAD kinase; Region: NAD_kinase; pfam01513 443150004724 DNA repair protein RecN; Region: recN; TIGR00634 443150004725 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 443150004726 Walker A/P-loop; other site 443150004727 ATP binding site [chemical binding]; other site 443150004728 Q-loop/lid; other site 443150004729 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 443150004730 ABC transporter signature motif; other site 443150004731 Walker B; other site 443150004732 D-loop; other site 443150004733 H-loop/switch region; other site 443150004734 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 443150004735 Thiamine pyrophosphokinase; Region: TPK; cl08415 443150004736 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 443150004737 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 443150004738 CTP synthetase; Validated; Region: pyrG; PRK05380 443150004739 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 443150004740 Catalytic site [active] 443150004741 active site 443150004742 UTP binding site [chemical binding]; other site 443150004743 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 443150004744 active site 443150004745 putative oxyanion hole; other site 443150004746 catalytic triad [active] 443150004747 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 443150004748 dimer interface [polypeptide binding]; other site 443150004749 ADP-ribose binding site [chemical binding]; other site 443150004750 active site 443150004751 nudix motif; other site 443150004752 metal binding site [ion binding]; metal-binding site 443150004753 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 443150004754 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 443150004755 active site 443150004756 DNA binding site [nucleotide binding] 443150004757 Int/Topo IB signature motif; other site 443150004758 Domain of unknown function (DUF222); Region: DUF222; pfam02720 443150004759 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 443150004760 active site 443150004761 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 443150004762 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443150004763 S-adenosylmethionine binding site [chemical binding]; other site 443150004764 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 443150004765 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150004766 PPE family; Region: PPE; pfam00823 443150004767 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 443150004768 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150004769 PPE family; Region: PPE; pfam00823 443150004770 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 443150004771 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 443150004772 Sulfate transporter family; Region: Sulfate_transp; pfam00916 443150004773 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 443150004774 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 443150004775 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 443150004776 P-loop; other site 443150004777 Magnesium ion binding site [ion binding]; other site 443150004778 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 443150004779 Magnesium ion binding site [ion binding]; other site 443150004780 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 443150004781 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 443150004782 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 443150004783 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 443150004784 RNA binding surface [nucleotide binding]; other site 443150004785 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 443150004786 active site 443150004787 cytidylate kinase; Provisional; Region: cmk; PRK00023 443150004788 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 443150004789 CMP-binding site; other site 443150004790 The sites determining sugar specificity; other site 443150004791 GTP-binding protein Der; Reviewed; Region: PRK03003 443150004792 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 443150004793 GTP/Mg2+ binding site [chemical binding]; other site 443150004794 Switch I region; other site 443150004795 G2 box; other site 443150004796 Switch II region; other site 443150004797 G3 box; other site 443150004798 G4 box; other site 443150004799 G5 box; other site 443150004800 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 443150004801 G1 box; other site 443150004802 GTP/Mg2+ binding site [chemical binding]; other site 443150004803 Switch I region; other site 443150004804 G2 box; other site 443150004805 G3 box; other site 443150004806 Switch II region; other site 443150004807 G4 box; other site 443150004808 G5 box; other site 443150004809 short chain dehydrogenase; Provisional; Region: PRK06841 443150004810 classical (c) SDRs; Region: SDR_c; cd05233 443150004811 NAD(P) binding site [chemical binding]; other site 443150004812 active site 443150004813 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 443150004814 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 443150004815 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 443150004816 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 443150004817 Cupin domain; Region: Cupin_2; pfam07883 443150004818 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 443150004819 Transcriptional regulator [Transcription]; Region: IclR; COG1414 443150004820 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 443150004821 putative switch regulator; other site 443150004822 non-specific DNA interactions [nucleotide binding]; other site 443150004823 DNA binding site [nucleotide binding] 443150004824 sequence specific DNA binding site [nucleotide binding]; other site 443150004825 putative cAMP binding site [chemical binding]; other site 443150004826 Bacterial transcriptional regulator; Region: IclR; pfam01614 443150004827 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 443150004828 putative active site [active] 443150004829 homotetrameric interface [polypeptide binding]; other site 443150004830 metal binding site [ion binding]; metal-binding site 443150004831 biotin carboxylase-like protein; Validated; Region: PRK06524 443150004832 ATP-grasp domain; Region: ATP-grasp_4; cl17255 443150004833 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 443150004834 Beta-lactamase; Region: Beta-lactamase; pfam00144 443150004835 Predicted transcriptional regulators [Transcription]; Region: COG1733 443150004836 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443150004837 dimerization interface [polypeptide binding]; other site 443150004838 putative DNA binding site [nucleotide binding]; other site 443150004839 putative Zn2+ binding site [ion binding]; other site 443150004840 Predicted transcriptional regulators [Transcription]; Region: COG1733 443150004841 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 443150004842 FAD binding domain; Region: FAD_binding_4; pfam01565 443150004843 Berberine and berberine like; Region: BBE; pfam08031 443150004844 TIGR03086 family protein; Region: TIGR03086 443150004845 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 443150004846 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 443150004847 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 443150004848 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 443150004849 Beta-lactamase; Region: Beta-lactamase; pfam00144 443150004850 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 443150004851 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 443150004852 NAD(P) binding site [chemical binding]; other site 443150004853 catalytic residues [active] 443150004854 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 443150004855 putative catalytic residue [active] 443150004856 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 443150004857 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 443150004858 gating phenylalanine in ion channel; other site 443150004859 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 443150004860 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 443150004861 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 443150004862 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 443150004863 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443150004864 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 443150004865 putative substrate translocation pore; other site 443150004866 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 443150004867 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 443150004868 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 443150004869 Sulfate transporter family; Region: Sulfate_transp; pfam00916 443150004870 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 443150004871 Protein tyrosine kinase; Region: Pkinase_Tyr; pfam07714 443150004872 Catalytic domain of Protein Kinases; Region: PKc; cd00180 443150004873 active site 443150004874 ATP binding site [chemical binding]; other site 443150004875 substrate binding site [chemical binding]; other site 443150004876 activation loop (A-loop); other site 443150004877 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 443150004878 Thioredoxin; Region: Thioredoxin_4; cl17273 443150004879 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 443150004880 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 443150004881 active site 443150004882 metal binding site [ion binding]; metal-binding site 443150004883 nudix motif; other site 443150004884 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 443150004885 Catalytic domain of Protein Kinases; Region: PKc; cd00180 443150004886 active site 443150004887 ATP binding site [chemical binding]; other site 443150004888 substrate binding site [chemical binding]; other site 443150004889 activation loop (A-loop); other site 443150004890 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 443150004891 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 443150004892 phosphopeptide binding site; other site 443150004893 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 443150004894 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 443150004895 phosphopeptide binding site; other site 443150004896 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 443150004897 The Eye Pigment Precursor Transporter (EPP) Family protein; Region: 3a01204; TIGR00955 443150004898 Walker A/P-loop; other site 443150004899 ATP binding site [chemical binding]; other site 443150004900 Q-loop/lid; other site 443150004901 ABC transporter signature motif; other site 443150004902 Walker B; other site 443150004903 D-loop; other site 443150004904 H-loop/switch region; other site 443150004905 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 443150004906 acyl-CoA synthetase; Provisional; Region: PRK13388 443150004907 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443150004908 acyl-activating enzyme (AAE) consensus motif; other site 443150004909 AMP binding site [chemical binding]; other site 443150004910 active site 443150004911 CoA binding site [chemical binding]; other site 443150004912 hypothetical protein; Provisional; Region: PRK06185 443150004913 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 443150004914 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 443150004915 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150004916 PPE family; Region: PPE; pfam00823 443150004917 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443150004918 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443150004919 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 443150004920 putative transposase OrfB; Reviewed; Region: PHA02517 443150004921 HTH-like domain; Region: HTH_21; pfam13276 443150004922 Integrase core domain; Region: rve; pfam00665 443150004923 Integrase core domain; Region: rve_3; pfam13683 443150004924 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 443150004925 Transposase; Region: HTH_Tnp_1; cl17663 443150004926 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 443150004927 PE family; Region: PE; pfam00934 443150004928 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 443150004929 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 443150004930 dimer interface [polypeptide binding]; other site 443150004931 active site 443150004932 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 443150004933 substrate binding site [chemical binding]; other site 443150004934 catalytic residue [active] 443150004935 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 443150004936 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 443150004937 metal binding site [ion binding]; metal-binding site 443150004938 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 443150004939 FAD binding domain; Region: FAD_binding_4; pfam01565 443150004940 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 443150004941 Transcriptional regulator [Transcription]; Region: IclR; COG1414 443150004942 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 443150004943 Bacterial transcriptional regulator; Region: IclR; pfam01614 443150004944 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 443150004945 FAD binding domain; Region: FAD_binding_4; pfam01565 443150004946 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443150004947 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443150004948 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443150004949 Cytochrome P450; Region: p450; cl12078 443150004950 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 443150004951 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 443150004952 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 443150004953 Protein of unknown function (DUF690); Region: DUF690; pfam05108 443150004954 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 443150004955 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 443150004956 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 443150004957 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 443150004958 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443150004959 Cytochrome P450; Region: p450; cl12078 443150004960 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150004961 PPE family; Region: PPE; pfam00823 443150004962 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 443150004963 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150004964 PPE family; Region: PPE; pfam00823 443150004965 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 443150004966 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150004967 PPE family; Region: PPE; pfam00823 443150004968 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 443150004969 EspG family; Region: ESX-1_EspG; pfam14011 443150004970 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 443150004971 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 443150004972 catalytic residues [active] 443150004973 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 443150004974 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 443150004975 active site 443150004976 catalytic residues [active] 443150004977 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 443150004978 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 443150004979 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443150004980 Walker A motif; other site 443150004981 ATP binding site [chemical binding]; other site 443150004982 Walker B motif; other site 443150004983 arginine finger; other site 443150004984 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150004985 PPE family; Region: PPE; pfam00823 443150004986 PE-PPE domain; Region: PE-PPE; pfam08237 443150004987 putative transposase OrfB; Reviewed; Region: PHA02517 443150004988 HTH-like domain; Region: HTH_21; pfam13276 443150004989 Integrase core domain; Region: rve; pfam00665 443150004990 Integrase core domain; Region: rve_3; pfam13683 443150004991 PE-PPE domain; Region: PE-PPE; pfam08237 443150004992 penicillin-binding protein 2; Provisional; Region: PRK10795 443150004993 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150004994 PPE family; Region: PPE; pfam00823 443150004995 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150004996 PPE family; Region: PPE; pfam00823 443150004997 PE family; Region: PE; pfam00934 443150004998 Protein of unknown function (DUF732); Region: DUF732; pfam05305 443150004999 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150005000 PPE family; Region: PPE; pfam00823 443150005001 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150005002 PPE family; Region: PPE; pfam00823 443150005003 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150005004 PPE family; Region: PPE; pfam00823 443150005005 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 443150005006 Protein of unknown function (DUF732); Region: DUF732; pfam05305 443150005007 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 443150005008 MgtC family; Region: MgtC; pfam02308 443150005009 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 443150005010 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 443150005011 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 443150005012 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 443150005013 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 443150005014 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443150005015 hypothetical protein; Validated; Region: PRK07121 443150005016 PE family; Region: PE; pfam00934 443150005017 ABC transporter transmembrane region 2; Region: ABC_membrane_2; pfam06472 443150005018 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 443150005019 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 443150005020 hypothetical protein; Provisional; Region: PRK05858 443150005021 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 443150005022 PYR/PP interface [polypeptide binding]; other site 443150005023 dimer interface [polypeptide binding]; other site 443150005024 TPP binding site [chemical binding]; other site 443150005025 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 443150005026 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 443150005027 TPP-binding site; other site 443150005028 dimer interface [polypeptide binding]; other site 443150005029 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 443150005030 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 443150005031 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 443150005032 nucleotide binding region [chemical binding]; other site 443150005033 ATP-binding site [chemical binding]; other site 443150005034 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 443150005035 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 443150005036 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 443150005037 Protein of unknown function (DUF1290); Region: DUF1290; cl01587 443150005038 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 443150005039 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 443150005040 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 443150005041 lipoyl attachment site [posttranslational modification]; other site 443150005042 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 443150005043 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 443150005044 phosphopeptide binding site; other site 443150005045 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 443150005046 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 443150005047 DNA binding residues [nucleotide binding] 443150005048 Bifunctional nuclease; Region: DNase-RNase; pfam02577 443150005049 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 443150005050 DNA binding residues [nucleotide binding] 443150005051 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 443150005052 putative dimer interface [polypeptide binding]; other site 443150005053 potential frameshift: common BLAST hit: gi|383307653|ref|YP_005360464.1| glycine dehydrogenase 443150005054 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 443150005055 glycine dehydrogenase; Provisional; Region: PRK05367 443150005056 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 443150005057 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 443150005058 tetramer interface [polypeptide binding]; other site 443150005059 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443150005060 catalytic residue [active] 443150005061 haloalkane dehalogenase; Provisional; Region: PRK03204 443150005062 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443150005063 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 443150005064 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 443150005065 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 443150005066 metal ion-dependent adhesion site (MIDAS); other site 443150005067 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 443150005068 active site 443150005069 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 443150005070 putative active site [active] 443150005071 Domain of unknown function DUF21; Region: DUF21; pfam01595 443150005072 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 443150005073 FOG: CBS domain [General function prediction only]; Region: COG0517 443150005074 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 443150005075 Domain of unknown function DUF21; Region: DUF21; pfam01595 443150005076 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 443150005077 Transporter associated domain; Region: CorC_HlyC; smart01091 443150005078 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 443150005079 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 443150005080 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 443150005081 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 443150005082 active site 443150005083 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 443150005084 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 443150005085 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 443150005086 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 443150005087 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 443150005088 CoenzymeA binding site [chemical binding]; other site 443150005089 subunit interaction site [polypeptide binding]; other site 443150005090 PHB binding site; other site 443150005091 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 443150005092 alpha-gamma subunit interface [polypeptide binding]; other site 443150005093 beta-gamma subunit interface [polypeptide binding]; other site 443150005094 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 443150005095 gamma-beta subunit interface [polypeptide binding]; other site 443150005096 alpha-beta subunit interface [polypeptide binding]; other site 443150005097 urease subunit alpha; Reviewed; Region: ureC; PRK13206 443150005098 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 443150005099 subunit interactions [polypeptide binding]; other site 443150005100 active site 443150005101 flap region; other site 443150005102 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 443150005103 UreF; Region: UreF; pfam01730 443150005104 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 443150005105 UreD urease accessory protein; Region: UreD; cl00530 443150005106 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 443150005107 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443150005108 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 443150005109 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 443150005110 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 443150005111 classical (c) SDRs; Region: SDR_c; cd05233 443150005112 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 443150005113 NAD(P) binding site [chemical binding]; other site 443150005114 active site 443150005115 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 443150005116 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 443150005117 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 443150005118 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443150005119 dimer interface [polypeptide binding]; other site 443150005120 conserved gate region; other site 443150005121 putative PBP binding loops; other site 443150005122 ABC-ATPase subunit interface; other site 443150005123 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 443150005124 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443150005125 Walker A/P-loop; other site 443150005126 ATP binding site [chemical binding]; other site 443150005127 Q-loop/lid; other site 443150005128 ABC transporter signature motif; other site 443150005129 Walker B; other site 443150005130 D-loop; other site 443150005131 H-loop/switch region; other site 443150005132 TOBE domain; Region: TOBE; pfam03459 443150005133 Fibronectin-attachment protein (FAP); Region: FAP; pfam07174 443150005134 Predicted membrane protein [Function unknown]; Region: COG2261 443150005135 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 443150005136 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 443150005137 putative NAD(P) binding site [chemical binding]; other site 443150005138 putative substrate binding site [chemical binding]; other site 443150005139 catalytic Zn binding site [ion binding]; other site 443150005140 structural Zn binding site [ion binding]; other site 443150005141 CAAX protease self-immunity; Region: Abi; pfam02517 443150005142 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 443150005143 MOSC domain; Region: MOSC; pfam03473 443150005144 short chain dehydrogenase; Provisional; Region: PRK07825 443150005145 classical (c) SDRs; Region: SDR_c; cd05233 443150005146 NAD(P) binding site [chemical binding]; other site 443150005147 active site 443150005148 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 443150005149 CoA-transferase family III; Region: CoA_transf_3; pfam02515 443150005150 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 443150005151 CoA-transferase family III; Region: CoA_transf_3; pfam02515 443150005152 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 443150005153 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 443150005154 active site 443150005155 hypothetical protein; Provisional; Region: PRK12320 443150005156 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443150005157 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 443150005158 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 443150005159 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443150005160 Domain of unknown function (DUF385); Region: DUF385; pfam04075 443150005161 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 443150005162 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 443150005163 active site 443150005164 substrate binding site [chemical binding]; other site 443150005165 FMN binding site [chemical binding]; other site 443150005166 putative catalytic residues [active] 443150005167 Uncharacterized conserved protein [Function unknown]; Region: COG5579 443150005168 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 443150005169 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 443150005170 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 443150005171 heme binding site [chemical binding]; other site 443150005172 ferroxidase pore; other site 443150005173 ferroxidase diiron center [ion binding]; other site 443150005174 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443150005175 Major Facilitator Superfamily; Region: MFS_1; pfam07690 443150005176 putative substrate translocation pore; other site 443150005177 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443150005178 putative substrate translocation pore; other site 443150005179 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cl00333 443150005180 23S rRNA interface [nucleotide binding]; other site 443150005181 L3 interface [polypeptide binding]; other site 443150005182 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 443150005183 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 443150005184 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 443150005185 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 443150005186 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443150005187 Cytochrome P450; Region: p450; cl12078 443150005188 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 443150005189 short chain dehydrogenase; Provisional; Region: PRK08267 443150005190 classical (c) SDR, subgroup 9; Region: SDR_c9; cd08931 443150005191 putative NAD(P) binding site [chemical binding]; other site 443150005192 active site 443150005193 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 443150005194 hydrophobic ligand binding site; other site 443150005195 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 443150005196 chorismate mutase; Provisional; Region: PRK09269 443150005197 chorismate mutase, putative; Region: CM_mono2; TIGR01806 443150005198 Putative esterase; Region: Esterase; pfam00756 443150005199 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 443150005200 Leucine carboxyl methyltransferase; Region: LCM; cl01306 443150005201 YceI-like domain; Region: YceI; cl01001 443150005202 Nitronate monooxygenase; Region: NMO; pfam03060 443150005203 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 443150005204 FMN binding site [chemical binding]; other site 443150005205 substrate binding site [chemical binding]; other site 443150005206 putative catalytic residue [active] 443150005207 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 443150005208 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 443150005209 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 443150005210 putative active site [active] 443150005211 dimerization interface [polypeptide binding]; other site 443150005212 putative tRNAtyr binding site [nucleotide binding]; other site 443150005213 Domain of unknown function DUF77; Region: DUF77; pfam01910 443150005214 Macro domain, Unknown family 2. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_2; cd03330 443150005215 putative ADP-ribose binding site [chemical binding]; other site 443150005216 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443150005217 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 443150005218 cyclase homology domain; Region: CHD; cd07302 443150005219 nucleotidyl binding site; other site 443150005220 metal binding site [ion binding]; metal-binding site 443150005221 dimer interface [polypeptide binding]; other site 443150005222 competence damage-inducible protein A; Provisional; Region: PRK00549 443150005223 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 443150005224 putative MPT binding site; other site 443150005225 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 443150005226 putative sialic acid transporter; Region: 2A0112; TIGR00891 443150005227 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443150005228 putative substrate translocation pore; other site 443150005229 Predicted membrane protein [Function unknown]; Region: COG1950 443150005230 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 443150005231 anti sigma factor interaction site; other site 443150005232 regulatory phosphorylation site [posttranslational modification]; other site 443150005233 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 443150005234 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 443150005235 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 443150005236 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 443150005237 dimer interface [polypeptide binding]; other site 443150005238 active site 443150005239 heme binding site [chemical binding]; other site 443150005240 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 443150005241 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 443150005242 metal binding site 2 [ion binding]; metal-binding site 443150005243 putative DNA binding helix; other site 443150005244 metal binding site 1 [ion binding]; metal-binding site 443150005245 dimer interface [polypeptide binding]; other site 443150005246 structural Zn2+ binding site [ion binding]; other site 443150005247 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 443150005248 substrate binding site [chemical binding]; other site 443150005249 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 443150005250 substrate binding site [chemical binding]; other site 443150005251 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 443150005252 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR3; cd08275 443150005253 putative NAD(P) binding site [chemical binding]; other site 443150005254 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 443150005255 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 443150005256 tetramer interface [polypeptide binding]; other site 443150005257 active site 443150005258 Mg2+/Mn2+ binding site [ion binding]; other site 443150005259 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 443150005260 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150005261 PPE family; Region: PPE; pfam00823 443150005262 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150005263 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443150005264 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443150005265 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150005266 PPE family; Region: PPE; pfam00823 443150005267 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443150005268 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443150005269 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 443150005270 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 443150005271 putative acyl-acceptor binding pocket; other site 443150005272 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 443150005273 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 443150005274 Beta-lactamase; Region: Beta-lactamase; pfam00144 443150005275 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 443150005276 Beta-lactamase; Region: Beta-lactamase; pfam00144 443150005277 putative fatty-acid--CoA ligase; Provisional; Region: PRK12476 443150005278 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 443150005279 acyl-activating enzyme (AAE) consensus motif; other site 443150005280 active site 443150005281 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 443150005282 Uncharacterized conserved protein [Function unknown]; Region: COG3361 443150005283 short chain dehydrogenase; Provisional; Region: PRK05867 443150005284 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443150005285 NAD(P) binding site [chemical binding]; other site 443150005286 active site 443150005287 TIGR03085 family protein; Region: TIGR03085 443150005288 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 443150005289 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 443150005290 dimer interface [polypeptide binding]; other site 443150005291 catalytic triad [active] 443150005292 peroxidatic and resolving cysteines [active] 443150005293 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443150005294 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 443150005295 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 443150005296 active site 443150005297 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443150005298 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 443150005299 FAD binding site [chemical binding]; other site 443150005300 substrate binding site [chemical binding]; other site 443150005301 catalytic base [active] 443150005302 enoyl-CoA hydratase; Provisional; Region: PRK08290 443150005303 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443150005304 substrate binding site [chemical binding]; other site 443150005305 oxyanion hole (OAH) forming residues; other site 443150005306 trimer interface [polypeptide binding]; other site 443150005307 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 443150005308 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 443150005309 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 443150005310 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443150005311 catalytic loop [active] 443150005312 iron binding site [ion binding]; other site 443150005313 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 443150005314 FAD binding pocket [chemical binding]; other site 443150005315 FAD binding motif [chemical binding]; other site 443150005316 phosphate binding motif [ion binding]; other site 443150005317 beta-alpha-beta structure motif; other site 443150005318 NAD binding pocket [chemical binding]; other site 443150005319 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443150005320 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 443150005321 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 443150005322 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 443150005323 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 443150005324 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 443150005325 dimerization interface [polypeptide binding]; other site 443150005326 active site 443150005327 classical (c) SDR, subgroup 12; Region: SDR_c12; cd08944 443150005328 putative NAD(P) binding site [chemical binding]; other site 443150005329 active site 443150005330 homodimer interface [polypeptide binding]; other site 443150005331 SEC-C motif; Region: SEC-C; pfam02810 443150005332 Domain of unknown function (DUF222); Region: DUF222; pfam02720 443150005333 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 443150005334 active site 443150005335 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487 443150005336 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 443150005337 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443150005338 non-specific DNA binding site [nucleotide binding]; other site 443150005339 salt bridge; other site 443150005340 sequence-specific DNA binding site [nucleotide binding]; other site 443150005341 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 443150005342 putative active site [active] 443150005343 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443150005344 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443150005345 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443150005346 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 443150005347 Permease; Region: Permease; pfam02405 443150005348 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 443150005349 Permease; Region: Permease; pfam02405 443150005350 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443150005351 mce related protein; Region: MCE; pfam02470 443150005352 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 443150005353 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443150005354 mce related protein; Region: MCE; pfam02470 443150005355 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443150005356 mce related protein; Region: MCE; pfam02470 443150005357 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443150005358 mce related protein; Region: MCE; pfam02470 443150005359 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443150005360 mce related protein; Region: MCE; pfam02470 443150005361 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443150005362 mce related protein; Region: MCE; pfam02470 443150005363 Protein of unknown function (DUF732); Region: DUF732; pfam05305 443150005364 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 443150005365 YacP-like NYN domain; Region: NYN_YacP; cl01491 443150005366 PE family; Region: PE; pfam00934 443150005367 Peptidase family M48; Region: Peptidase_M48; pfam01435 443150005368 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443150005369 S-adenosylmethionine binding site [chemical binding]; other site 443150005370 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 443150005371 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 443150005372 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 443150005373 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 443150005374 dimer interface [polypeptide binding]; other site 443150005375 putative radical transfer pathway; other site 443150005376 diiron center [ion binding]; other site 443150005377 tyrosyl radical; other site 443150005378 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 443150005379 putative active site [active] 443150005380 PE family; Region: PE; pfam00934 443150005381 Cutinase; Region: Cutinase; pfam01083 443150005382 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 443150005383 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 443150005384 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 443150005385 dimerization interface [polypeptide binding]; other site 443150005386 Lysine efflux permease [General function prediction only]; Region: COG1279 443150005387 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443150005388 S-adenosylmethionine binding site [chemical binding]; other site 443150005389 Uncharacterized conserved protein [Function unknown]; Region: COG5654 443150005390 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 443150005391 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 443150005392 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 443150005393 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 443150005394 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443150005395 dimerization interface [polypeptide binding]; other site 443150005396 putative DNA binding site [nucleotide binding]; other site 443150005397 putative Zn2+ binding site [ion binding]; other site 443150005398 Hemerythrin-like domain; Region: Hr-like; cd12108 443150005399 Fe binding site [ion binding]; other site 443150005400 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 443150005401 Ligand Binding Site [chemical binding]; other site 443150005402 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 443150005403 Ligand Binding Site [chemical binding]; other site 443150005404 potential frameshift: common BLAST hit: gi|375296201|ref|YP_005100468.1| metal cation transporting P-type ATPase ctpF 443150005405 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 443150005406 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 443150005407 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 443150005408 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 443150005409 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 443150005410 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 443150005411 Soluble P-type ATPase [General function prediction only]; Region: COG4087 443150005412 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 443150005413 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 443150005414 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 443150005415 tetramer interface [polypeptide binding]; other site 443150005416 active site 443150005417 Mg2+/Mn2+ binding site [ion binding]; other site 443150005418 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 443150005419 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 443150005420 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 443150005421 3beta17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 3beta-17beta-HSD_like_SDR_c; cd05341 443150005422 homotetramer interface [polypeptide binding]; other site 443150005423 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 443150005424 NAD binding site [chemical binding]; other site 443150005425 homodimer interface [polypeptide binding]; other site 443150005426 active site 443150005427 Methyltransferase domain; Region: Methyltransf_23; pfam13489 443150005428 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443150005429 S-adenosylmethionine binding site [chemical binding]; other site 443150005430 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 443150005431 Predicted kinase [General function prediction only]; Region: COG0645 443150005432 AAA domain; Region: AAA_17; pfam13207 443150005433 Universal stress protein family; Region: Usp; pfam00582 443150005434 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 443150005435 Ligand Binding Site [chemical binding]; other site 443150005436 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 443150005437 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 443150005438 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 443150005439 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 443150005440 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 443150005441 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 443150005442 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 443150005443 Ferredoxin [Energy production and conversion]; Region: COG1146 443150005444 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 443150005445 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 443150005446 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443150005447 Walker A motif; other site 443150005448 ATP binding site [chemical binding]; other site 443150005449 Walker B motif; other site 443150005450 arginine finger; other site 443150005451 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 443150005452 putative active site [active] 443150005453 Transcriptional regulators [Transcription]; Region: MarR; COG1846 443150005454 MarR family; Region: MarR_2; pfam12802 443150005455 Phage envelope protein [General function prediction only]; Region: COG5562 443150005456 Transposase; Region: DEDD_Tnp_IS110; pfam01548 443150005457 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 443150005458 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 443150005459 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 443150005460 Domain of unknown function (DUF222); Region: DUF222; pfam02720 443150005461 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 443150005462 active site 443150005463 putative transposase OrfB; Reviewed; Region: PHA02517 443150005464 HTH-like domain; Region: HTH_21; pfam13276 443150005465 Integrase core domain; Region: rve; pfam00665 443150005466 Integrase core domain; Region: rve_3; pfam13683 443150005467 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 443150005468 Transposase; Region: HTH_Tnp_1; cl17663 443150005469 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 443150005470 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443150005471 non-specific DNA binding site [nucleotide binding]; other site 443150005472 salt bridge; other site 443150005473 sequence-specific DNA binding site [nucleotide binding]; other site 443150005474 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 443150005475 Uncharacterized conserved protein [Function unknown]; Region: COG2442 443150005476 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443150005477 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 443150005478 non-specific DNA binding site [nucleotide binding]; other site 443150005479 salt bridge; other site 443150005480 sequence-specific DNA binding site [nucleotide binding]; other site 443150005481 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4683 443150005482 Predicted helicase [General function prediction only]; Region: COG4889 443150005483 Restriction endonuclease; Region: Mrr_cat_2; pfam13156 443150005484 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 443150005485 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443150005486 ATP binding site [chemical binding]; other site 443150005487 putative Mg++ binding site [ion binding]; other site 443150005488 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 443150005489 ATP-binding site [chemical binding]; other site 443150005490 Methyltransferase domain; Region: Methyltransf_26; pfam13659 443150005491 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 443150005492 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 443150005493 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 443150005494 Ligand Binding Site [chemical binding]; other site 443150005495 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 443150005496 Ligand Binding Site [chemical binding]; other site 443150005497 potential frameshift: common BLAST hit: gi|383307840|ref|YP_005360651.1| histidine kinase response regulator 443150005498 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 443150005499 Histidine kinase; Region: HisKA_3; pfam07730 443150005500 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 443150005501 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 443150005502 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 443150005503 Ligand Binding Site [chemical binding]; other site 443150005504 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 443150005505 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 443150005506 putative substrate binding site [chemical binding]; other site 443150005507 putative ATP binding site [chemical binding]; other site 443150005508 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 443150005509 active site 443150005510 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 443150005511 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 443150005512 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 443150005513 putative dimer interface [polypeptide binding]; other site 443150005514 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 443150005515 dimer interface [polypeptide binding]; other site 443150005516 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 443150005517 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443150005518 putative DNA binding site [nucleotide binding]; other site 443150005519 dimerization interface [polypeptide binding]; other site 443150005520 putative Zn2+ binding site [ion binding]; other site 443150005521 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 443150005522 putative hydrophobic ligand binding site [chemical binding]; other site 443150005523 CLM binding site; other site 443150005524 L1 loop; other site 443150005525 DNA binding site [nucleotide binding] 443150005526 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 443150005527 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 443150005528 MDMPI C-terminal domain; Region: MDMPI_C; pfam07398 443150005529 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 443150005530 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 443150005531 nucleophile elbow; other site 443150005532 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 443150005533 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 443150005534 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 443150005535 Walker A/P-loop; other site 443150005536 ATP binding site [chemical binding]; other site 443150005537 Q-loop/lid; other site 443150005538 ABC transporter signature motif; other site 443150005539 Walker B; other site 443150005540 D-loop; other site 443150005541 H-loop/switch region; other site 443150005542 TOBE domain; Region: TOBE_2; pfam08402 443150005543 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 443150005544 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443150005545 dimer interface [polypeptide binding]; other site 443150005546 conserved gate region; other site 443150005547 putative PBP binding loops; other site 443150005548 ABC-ATPase subunit interface; other site 443150005549 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 443150005550 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443150005551 dimer interface [polypeptide binding]; other site 443150005552 conserved gate region; other site 443150005553 putative PBP binding loops; other site 443150005554 ABC-ATPase subunit interface; other site 443150005555 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 443150005556 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 443150005557 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 443150005558 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 443150005559 Isochorismatase family; Region: Isochorismatase; pfam00857 443150005560 catalytic triad [active] 443150005561 metal binding site [ion binding]; metal-binding site 443150005562 conserved cis-peptide bond; other site 443150005563 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 443150005564 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 443150005565 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 443150005566 substrate binding pocket [chemical binding]; other site 443150005567 catalytic triad [active] 443150005568 hypothetical protein; Provisional; Region: PRK05865 443150005569 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443150005570 NAD(P) binding site [chemical binding]; other site 443150005571 active site 443150005572 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 443150005573 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 443150005574 NAD(P) binding site [chemical binding]; other site 443150005575 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 443150005576 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 443150005577 putative NADP binding site [chemical binding]; other site 443150005578 active site 443150005579 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 443150005580 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 443150005581 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 443150005582 active site 443150005583 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 443150005584 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 443150005585 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443150005586 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 443150005587 Enoylreductase; Region: PKS_ER; smart00829 443150005588 NAD(P) binding site [chemical binding]; other site 443150005589 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 443150005590 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 443150005591 putative NADP binding site [chemical binding]; other site 443150005592 active site 443150005593 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 443150005594 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 443150005595 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 443150005596 active site 443150005597 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 443150005598 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 443150005599 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 443150005600 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443150005601 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 443150005602 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 443150005603 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 443150005604 putative active site [active] 443150005605 catalytic triad [active] 443150005606 putative dimer interface [polypeptide binding]; other site 443150005607 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 443150005608 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 443150005609 Ligand binding site; other site 443150005610 Putative Catalytic site; other site 443150005611 DXD motif; other site 443150005612 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 443150005613 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 443150005614 active site 443150005615 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 443150005616 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 443150005617 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 443150005618 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 443150005619 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 443150005620 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 443150005621 intersubunit interface [polypeptide binding]; other site 443150005622 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 443150005623 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 443150005624 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 443150005625 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 443150005626 precorrin-3B synthase; Region: CobG; TIGR02435 443150005627 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 443150005628 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 443150005629 Precorrin-8X methylmutase; Region: CbiC; pfam02570 443150005630 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 443150005631 active site 443150005632 SAM binding site [chemical binding]; other site 443150005633 homodimer interface [polypeptide binding]; other site 443150005634 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 443150005635 active site 443150005636 SAM binding site [chemical binding]; other site 443150005637 homodimer interface [polypeptide binding]; other site 443150005638 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 443150005639 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 443150005640 RNA polymerase sigma factor SigC; Reviewed; Region: PRK09649 443150005641 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443150005642 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443150005643 DNA binding residues [nucleotide binding] 443150005644 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 443150005645 precorrin-6x reductase; Region: precor6x_red; TIGR00715 443150005646 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 443150005647 active site 443150005648 SAM binding site [chemical binding]; other site 443150005649 homodimer interface [polypeptide binding]; other site 443150005650 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 443150005651 active site 443150005652 putative homodimer interface [polypeptide binding]; other site 443150005653 SAM binding site [chemical binding]; other site 443150005654 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 443150005655 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 443150005656 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443150005657 NAD(P) binding site [chemical binding]; other site 443150005658 active site 443150005659 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 443150005660 Catalytic domain of uncharacterized Mycobacterium tuberculosis Rv2075c-like proteins; Region: PI-PLCc_Rv2075c_like; cd08590 443150005661 putative active site [active] 443150005662 catalytic site [active] 443150005663 putative metal binding site [ion binding]; other site 443150005664 C-type lectin (CTL)/C-type lectin-like (CTLD) domain; Region: CLECT; cl02432 443150005665 Protein of unknown function (DUF2563); Region: DUF2563; pfam10817 443150005666 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 443150005667 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 443150005668 Catalytic domain of Protein Kinases; Region: PKc; cd00180 443150005669 active site 443150005670 ATP binding site [chemical binding]; other site 443150005671 substrate binding site [chemical binding]; other site 443150005672 activation loop (A-loop); other site 443150005673 PknH-like extracellular domain; Region: PknH_C; pfam14032 443150005674 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 443150005675 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 443150005676 active site 443150005677 5'-3' exonuclease, N-terminal resolvase-like domain; Region: 5_3_exonuc_N; pfam02739 443150005678 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 443150005679 active site 443150005680 metal binding site 1 [ion binding]; metal-binding site 443150005681 putative 5' ssDNA interaction site; other site 443150005682 metal binding site 3; metal-binding site 443150005683 metal binding site 2 [ion binding]; metal-binding site 443150005684 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 443150005685 putative DNA binding site [nucleotide binding]; other site 443150005686 putative metal binding site [ion binding]; other site 443150005687 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 443150005688 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 443150005689 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443150005690 ATP binding site [chemical binding]; other site 443150005691 putative Mg++ binding site [ion binding]; other site 443150005692 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443150005693 nucleotide binding region [chemical binding]; other site 443150005694 ATP-binding site [chemical binding]; other site 443150005695 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 443150005696 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 443150005697 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 443150005698 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 443150005699 Predicted transcriptional regulator [Transcription]; Region: COG2378 443150005700 WYL domain; Region: WYL; pfam13280 443150005701 Predicted transcriptional regulator [Transcription]; Region: COG2378 443150005702 WYL domain; Region: WYL; pfam13280 443150005703 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 443150005704 PE family; Region: PE; pfam00934 443150005705 Domain of unknown function (DUF222); Region: DUF222; pfam02720 443150005706 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 443150005707 active site 443150005708 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 443150005709 SNF2 Helicase protein; Region: DUF3670; pfam12419 443150005710 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443150005711 ATP binding site [chemical binding]; other site 443150005712 putative Mg++ binding site [ion binding]; other site 443150005713 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443150005714 nucleotide binding region [chemical binding]; other site 443150005715 ATP-binding site [chemical binding]; other site 443150005716 Uncharacterized conserved protein [Function unknown]; Region: COG4279 443150005717 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 443150005718 putative active site [active] 443150005719 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 443150005720 Transposase; Region: HTH_Tnp_1; cl17663 443150005721 putative transposase OrfB; Reviewed; Region: PHA02517 443150005722 HTH-like domain; Region: HTH_21; pfam13276 443150005723 Integrase core domain; Region: rve; pfam00665 443150005724 Integrase core domain; Region: rve_3; pfam13683 443150005725 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150005726 PPE family; Region: PPE; pfam00823 443150005727 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 443150005728 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 443150005729 active site 443150005730 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 443150005731 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 443150005732 active site 443150005733 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 443150005734 proteasome ATPase; Region: pup_AAA; TIGR03689 443150005735 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443150005736 Walker A motif; other site 443150005737 ATP binding site [chemical binding]; other site 443150005738 Walker B motif; other site 443150005739 arginine finger; other site 443150005740 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 443150005741 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 443150005742 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443150005743 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 443150005744 Predicted membrane protein [Function unknown]; Region: COG3918 443150005745 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 443150005746 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 443150005747 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 443150005748 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150005749 PPE family; Region: PPE; pfam00823 443150005750 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 443150005751 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 443150005752 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 443150005753 substrate binding pocket [chemical binding]; other site 443150005754 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 443150005755 B12 binding site [chemical binding]; other site 443150005756 cobalt ligand [ion binding]; other site 443150005757 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 443150005758 PAC2 family; Region: PAC2; pfam09754 443150005759 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 443150005760 short chain dehydrogenase; Provisional; Region: PRK05872 443150005761 classical (c) SDRs; Region: SDR_c; cd05233 443150005762 NAD(P) binding site [chemical binding]; other site 443150005763 active site 443150005764 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 443150005765 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 443150005766 active site 443150005767 HIGH motif; other site 443150005768 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 443150005769 active site 443150005770 KMSKS motif; other site 443150005771 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 443150005772 putative tRNA binding surface [nucleotide binding]; other site 443150005773 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 443150005774 active site 443150005775 conserved hypothetical protein; Region: TIGR03843 443150005776 conserved hypothetical protein; Region: TIGR03847 443150005777 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 443150005778 catalytic core [active] 443150005779 undecaprenyl-diphosphatase UppP; Region: undec_PP_bacA; TIGR00753 443150005780 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 443150005781 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 443150005782 quinone interaction residues [chemical binding]; other site 443150005783 active site 443150005784 catalytic residues [active] 443150005785 FMN binding site [chemical binding]; other site 443150005786 substrate binding site [chemical binding]; other site 443150005787 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 443150005788 substrate binding site [chemical binding]; other site 443150005789 hypothetical protein; Provisional; Region: PRK07906 443150005790 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 443150005791 putative metal binding site [ion binding]; other site 443150005792 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 443150005793 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 443150005794 active site 443150005795 DivIVA domain; Region: DivI1A_domain; TIGR03544 443150005796 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 443150005797 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 443150005798 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 443150005799 Predicted enzyme with a TIM-barrel fold [General function prediction only]; Region: COG0325 443150005800 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 443150005801 catalytic residue [active] 443150005802 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 443150005803 uncharacterized protein, YfiH family; Region: TIGR00726 443150005804 cell division protein FtsZ; Validated; Region: PRK09330 443150005805 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 443150005806 nucleotide binding site [chemical binding]; other site 443150005807 SulA interaction site; other site 443150005808 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 443150005809 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 443150005810 Cell division protein FtsQ; Region: FtsQ; pfam03799 443150005811 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 443150005812 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 443150005813 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 443150005814 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 443150005815 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 443150005816 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 443150005817 active site 443150005818 homodimer interface [polypeptide binding]; other site 443150005819 cell division protein FtsW; Region: ftsW; TIGR02614 443150005820 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369 443150005821 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 443150005822 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 443150005823 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 443150005824 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 443150005825 Mg++ binding site [ion binding]; other site 443150005826 putative catalytic motif [active] 443150005827 putative substrate binding site [chemical binding]; other site 443150005828 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 443150005829 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 443150005830 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 443150005831 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 443150005832 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 443150005833 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 443150005834 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 443150005835 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443150005836 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443150005837 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 443150005838 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 443150005839 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 443150005840 PE family; Region: PE; pfam00934 443150005841 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 443150005842 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 443150005843 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 443150005844 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 443150005845 MraW methylase family; Region: Methyltransf_5; pfam01795 443150005846 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 443150005847 MraZ protein; Region: MraZ; pfam02381 443150005848 MraZ protein; Region: MraZ; pfam02381 443150005849 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 443150005850 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 443150005851 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 443150005852 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 443150005853 substrate binding pocket [chemical binding]; other site 443150005854 chain length determination region; other site 443150005855 substrate-Mg2+ binding site; other site 443150005856 catalytic residues [active] 443150005857 aspartate-rich region 1; other site 443150005858 active site lid residues [active] 443150005859 aspartate-rich region 2; other site 443150005860 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 443150005861 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 443150005862 Catalytic domain of Protein Kinases; Region: PKc; cd00180 443150005863 active site 443150005864 ATP binding site [chemical binding]; other site 443150005865 substrate binding site [chemical binding]; other site 443150005866 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 443150005867 substrate binding site [chemical binding]; other site 443150005868 activation loop (A-loop); other site 443150005869 activation loop (A-loop); other site 443150005870 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 443150005871 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 443150005872 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG3200 443150005873 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 443150005874 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 443150005875 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 443150005876 putative acyl-acceptor binding pocket; other site 443150005877 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 443150005878 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 443150005879 DTAP/Switch II; other site 443150005880 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 443150005881 putative hydrophobic ligand binding site [chemical binding]; other site 443150005882 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 443150005883 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 443150005884 acyl-activating enzyme (AAE) consensus motif; other site 443150005885 putative AMP binding site [chemical binding]; other site 443150005886 putative active site [active] 443150005887 putative CoA binding site [chemical binding]; other site 443150005888 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 443150005889 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443150005890 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 443150005891 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 443150005892 NlpC/P60 family; Region: NLPC_P60; pfam00877 443150005893 hypothetical protein; Validated; Region: PRK07883 443150005894 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 443150005895 active site 443150005896 catalytic site [active] 443150005897 substrate binding site [chemical binding]; other site 443150005898 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 443150005899 GIY-YIG motif/motif A; other site 443150005900 active site 443150005901 catalytic site [active] 443150005902 putative DNA binding site [nucleotide binding]; other site 443150005903 metal binding site [ion binding]; metal-binding site 443150005904 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 443150005905 Subunit I/III interface [polypeptide binding]; other site 443150005906 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 443150005907 Cytochrome c; Region: Cytochrom_C; pfam00034 443150005908 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 443150005909 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 443150005910 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 443150005911 iron-sulfur cluster [ion binding]; other site 443150005912 [2Fe-2S] cluster binding site [ion binding]; other site 443150005913 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 443150005914 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 443150005915 heme bH binding site [chemical binding]; other site 443150005916 intrachain domain interface; other site 443150005917 heme bL binding site [chemical binding]; other site 443150005918 interchain domain interface [polypeptide binding]; other site 443150005919 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 443150005920 Qo binding site; other site 443150005921 Protein of unknown function (DUF2561); Region: DUF2561; pfam10812 443150005922 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 443150005923 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 443150005924 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 443150005925 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 443150005926 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 443150005927 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 443150005928 dimer interface [polypeptide binding]; other site 443150005929 active site 443150005930 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 443150005931 Ligand Binding Site [chemical binding]; other site 443150005932 Molecular Tunnel; other site 443150005933 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 443150005934 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 443150005935 substrate binding site [chemical binding]; other site 443150005936 ATP binding site [chemical binding]; other site 443150005937 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 443150005938 Glycerate kinase family; Region: Gly_kinase; pfam02595 443150005939 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 443150005940 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 443150005941 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 443150005942 putative dimer interface [polypeptide binding]; other site 443150005943 active site pocket [active] 443150005944 putative cataytic base [active] 443150005945 Cobalamin-5-phosphate synthase; Region: CobS; pfam02654 443150005946 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 443150005947 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 443150005948 homodimer interface [polypeptide binding]; other site 443150005949 substrate-cofactor binding pocket; other site 443150005950 catalytic residue [active] 443150005951 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 443150005952 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 443150005953 cyclase homology domain; Region: CHD; cd07302 443150005954 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 443150005955 nucleotidyl binding site; other site 443150005956 metal binding site [ion binding]; metal-binding site 443150005957 dimer interface [polypeptide binding]; other site 443150005958 multifunctional aminopeptidase A; Provisional; Region: PRK00913 443150005959 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 443150005960 interface (dimer of trimers) [polypeptide binding]; other site 443150005961 Substrate-binding/catalytic site; other site 443150005962 Zn-binding sites [ion binding]; other site 443150005963 short chain dehydrogenase; Validated; Region: PRK05855 443150005964 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 443150005965 classical (c) SDRs; Region: SDR_c; cd05233 443150005966 NAD(P) binding site [chemical binding]; other site 443150005967 active site 443150005968 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 443150005969 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 443150005970 E3 interaction surface; other site 443150005971 lipoyl attachment site [posttranslational modification]; other site 443150005972 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 443150005973 E3 interaction surface; other site 443150005974 lipoyl attachment site [posttranslational modification]; other site 443150005975 e3 binding domain; Region: E3_binding; pfam02817 443150005976 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 443150005977 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 443150005978 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 443150005979 putative NAD(P) binding site [chemical binding]; other site 443150005980 putative active site [active] 443150005981 lipoate-protein ligase B; Provisional; Region: PRK14345 443150005982 lipoyl synthase; Provisional; Region: PRK05481 443150005983 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443150005984 FeS/SAM binding site; other site 443150005985 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 443150005986 RDD family; Region: RDD; pfam06271 443150005987 glutamine synthetase, type I; Region: GlnA; TIGR00653 443150005988 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 443150005989 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 443150005990 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 443150005991 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 443150005992 metal binding triad; other site 443150005993 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 443150005994 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 443150005995 metal binding triad; other site 443150005996 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 443150005997 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 443150005998 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 443150005999 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 443150006000 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 443150006001 TAP-like protein; Region: Abhydrolase_4; pfam08386 443150006002 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 443150006003 TAP-like protein; Region: Abhydrolase_4; pfam08386 443150006004 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 443150006005 oligomerization interface [polypeptide binding]; other site 443150006006 active site 443150006007 metal binding site [ion binding]; metal-binding site 443150006008 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 443150006009 putative active site; other site 443150006010 putative metal binding residues [ion binding]; other site 443150006011 signature motif; other site 443150006012 putative triphosphate binding site [ion binding]; other site 443150006013 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 443150006014 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3826 443150006015 potential frameshift: common BLAST hit: gi|383308027|ref|YP_005360838.1| bifunctional RNase H/acid phosphatase 443150006016 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 443150006017 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 443150006018 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 443150006019 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 443150006020 RNA/DNA hybrid binding site [nucleotide binding]; other site 443150006021 active site 443150006022 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 443150006023 Putative zinc ribbon domain; Region: DUF164; pfam02591 443150006024 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 443150006025 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 443150006026 Uncharacterized conserved protein [Function unknown]; Region: COG0327 443150006027 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 443150006028 hypothetical protein; Provisional; Region: PRK07908 443150006029 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443150006030 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443150006031 homodimer interface [polypeptide binding]; other site 443150006032 catalytic residue [active] 443150006033 phosphoglycolate phosphatase; Provisional; Region: PRK13222 443150006034 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443150006035 active site 443150006036 motif I; other site 443150006037 motif II; other site 443150006038 Low molecular weight phosphatase family; Region: LMWPc; cd00115 443150006039 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 443150006040 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 443150006041 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 443150006042 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 443150006043 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 443150006044 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 443150006045 dimer interface [polypeptide binding]; other site 443150006046 catalytic triad [active] 443150006047 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 443150006048 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 443150006049 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 443150006050 dimer interface [polypeptide binding]; other site 443150006051 TPP-binding site [chemical binding]; other site 443150006052 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 443150006053 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 443150006054 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 443150006055 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 443150006056 acyl carrier protein; Provisional; Region: acpP; PRK00982 443150006057 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 443150006058 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 443150006059 dimer interface [polypeptide binding]; other site 443150006060 active site 443150006061 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 443150006062 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 443150006063 dimer interface [polypeptide binding]; other site 443150006064 active site 443150006065 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 443150006066 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 443150006067 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 443150006068 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 443150006069 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 443150006070 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443150006071 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443150006072 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 443150006073 FAD binding domain; Region: FAD_binding_4; pfam01565 443150006074 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 443150006075 diacylglycerol kinase; Reviewed; Region: PRK11914 443150006076 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 443150006077 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 443150006078 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 443150006079 Beta-lactamase; Region: Beta-lactamase; pfam00144 443150006080 Methyltransferase domain; Region: Methyltransf_31; pfam13847 443150006081 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443150006082 S-adenosylmethionine binding site [chemical binding]; other site 443150006083 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 443150006084 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 443150006085 NAD binding site [chemical binding]; other site 443150006086 catalytic Zn binding site [ion binding]; other site 443150006087 substrate binding site [chemical binding]; other site 443150006088 structural Zn binding site [ion binding]; other site 443150006089 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 443150006090 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 443150006091 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 443150006092 putative active site [active] 443150006093 catalytic triad [active] 443150006094 putative dimer interface [polypeptide binding]; other site 443150006095 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443150006096 active site 443150006097 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 443150006098 nucleotide binding site [chemical binding]; other site 443150006099 Major Facilitator Superfamily; Region: MFS_1; pfam07690 443150006100 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443150006101 Cytochrome P450; Region: p450; cl12078 443150006102 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 443150006103 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443150006104 Cytochrome P450; Region: p450; cl12078 443150006105 Septum formation; Region: Septum_form; pfam13845 443150006106 Predicted membrane protein [Function unknown]; Region: COG2149 443150006107 Domain of unknown function (DUF202); Region: DUF202; pfam02656 443150006108 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443150006109 Cytochrome P450; Region: p450; cl12078 443150006110 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial protein Rv2277c and similar proteins; Region: GDPD_Rv2277c_like; cd08580 443150006111 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 443150006112 putative active site [active] 443150006113 catalytic site [active] 443150006114 putative metal binding site [ion binding]; other site 443150006115 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 443150006116 FAD binding domain; Region: FAD_binding_4; pfam01565 443150006117 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 443150006118 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 443150006119 Transcriptional regulator [Transcription]; Region: LysR; COG0583 443150006120 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 443150006121 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 443150006122 dimerization interface [polypeptide binding]; other site 443150006123 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 443150006124 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 443150006125 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 443150006126 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443150006127 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443150006128 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 443150006129 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 443150006130 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 443150006131 CDP-diacylglycerol pyrophosphatase [Lipid metabolism]; Region: Cdh; COG2134 443150006132 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 443150006133 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 443150006134 active site residue [active] 443150006135 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 443150006136 active site residue [active] 443150006137 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 443150006138 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 443150006139 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443150006140 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443150006141 homodimer interface [polypeptide binding]; other site 443150006142 catalytic residue [active] 443150006143 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3196 443150006144 haloalkane dehalogenase; Provisional; Region: PRK00870 443150006145 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 443150006146 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 443150006147 active site 443150006148 catalytic tetrad [active] 443150006149 heat shock protein 90; Provisional; Region: PRK05218 443150006150 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443150006151 ATP binding site [chemical binding]; other site 443150006152 Mg2+ binding site [ion binding]; other site 443150006153 G-X-G motif; other site 443150006154 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 443150006155 Cutinase; Region: Cutinase; pfam01083 443150006156 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 443150006157 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 443150006158 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 443150006159 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 443150006160 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 443150006161 Uncharacterized conserved protein [Function unknown]; Region: COG2442 443150006162 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 443150006163 DNA binding site [nucleotide binding] 443150006164 active site 443150006165 Int/Topo IB signature motif; other site 443150006166 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 443150006167 DNA binding residues [nucleotide binding] 443150006168 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507 443150006169 Uncharacterized conserved protein [Function unknown]; Region: COG2128 443150006170 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 443150006171 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 443150006172 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443150006173 putative PBP binding loops; other site 443150006174 ABC-ATPase subunit interface; other site 443150006175 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 443150006176 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443150006177 dimer interface [polypeptide binding]; other site 443150006178 conserved gate region; other site 443150006179 putative PBP binding loops; other site 443150006180 ABC-ATPase subunit interface; other site 443150006181 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 443150006182 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 443150006183 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 443150006184 Ligand Binding Site [chemical binding]; other site 443150006185 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 443150006186 Ligand Binding Site [chemical binding]; other site 443150006187 amino acid transporter; Region: 2A0306; TIGR00909 443150006188 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 443150006189 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 443150006190 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 443150006191 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443150006192 catalytic residue [active] 443150006193 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 443150006194 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443150006195 Amidinotransferase; Region: Amidinotransf; pfam02274 443150006196 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 443150006197 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 443150006198 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 443150006199 putative DNA binding site [nucleotide binding]; other site 443150006200 putative Zn2+ binding site [ion binding]; other site 443150006201 AsnC family; Region: AsnC_trans_reg; pfam01037 443150006202 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 443150006203 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 443150006204 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 443150006205 Walker A/P-loop; other site 443150006206 ATP binding site [chemical binding]; other site 443150006207 Q-loop/lid; other site 443150006208 ABC transporter signature motif; other site 443150006209 Walker B; other site 443150006210 D-loop; other site 443150006211 H-loop/switch region; other site 443150006212 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 443150006213 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 443150006214 Walker A/P-loop; other site 443150006215 ATP binding site [chemical binding]; other site 443150006216 Q-loop/lid; other site 443150006217 ABC transporter signature motif; other site 443150006218 Walker B; other site 443150006219 D-loop; other site 443150006220 H-loop/switch region; other site 443150006221 MarR family; Region: MarR; pfam01047 443150006222 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 443150006223 PE family; Region: PE; pfam00934 443150006224 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 443150006225 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443150006226 putative substrate translocation pore; other site 443150006227 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 443150006228 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 443150006229 malate dehydrogenase; Provisional; Region: PRK13529 443150006230 Malic enzyme, N-terminal domain; Region: malic; pfam00390 443150006231 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 443150006232 NAD(P) binding site [chemical binding]; other site 443150006233 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443150006234 Major Facilitator Superfamily; Region: MFS_1; pfam07690 443150006235 putative substrate translocation pore; other site 443150006236 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443150006237 putative substrate translocation pore; other site 443150006238 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 443150006239 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 443150006240 dimer interface [polypeptide binding]; other site 443150006241 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443150006242 catalytic residue [active] 443150006243 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 443150006244 serine O-acetyltransferase; Region: cysE; TIGR01172 443150006245 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 443150006246 trimer interface [polypeptide binding]; other site 443150006247 active site 443150006248 substrate binding site [chemical binding]; other site 443150006249 CoA binding site [chemical binding]; other site 443150006250 hypothetical protein; Provisional; Region: PRK14851 443150006251 hypothetical protein; Validated; Region: PRK08223 443150006252 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 443150006253 ATP binding site [chemical binding]; other site 443150006254 substrate interface [chemical binding]; other site 443150006255 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 443150006256 PE family; Region: PE; pfam00934 443150006257 DNA primase; Validated; Region: dnaG; PRK05667 443150006258 CHC2 zinc finger; Region: zf-CHC2; pfam01807 443150006259 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 443150006260 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 443150006261 active site 443150006262 metal binding site [ion binding]; metal-binding site 443150006263 interdomain interaction site; other site 443150006264 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 443150006265 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 443150006266 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 443150006267 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443150006268 Zn2+ binding site [ion binding]; other site 443150006269 Mg2+ binding site [ion binding]; other site 443150006270 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 443150006271 Repair protein; Region: Repair_PSII; pfam04536 443150006272 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 443150006273 Phosphoesterase family; Region: Phosphoesterase; pfam04185 443150006274 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 443150006275 Phosphoesterase family; Region: Phosphoesterase; pfam04185 443150006276 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 443150006277 Phosphoesterase family; Region: Phosphoesterase; pfam04185 443150006278 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150006279 PPE family; Region: PPE; pfam00823 443150006280 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 443150006281 Transposase; Region: HTH_Tnp_1; cl17663 443150006282 putative transposase OrfB; Reviewed; Region: PHA02517 443150006283 HTH-like domain; Region: HTH_21; pfam13276 443150006284 Integrase core domain; Region: rve; pfam00665 443150006285 Integrase core domain; Region: rve_3; pfam13683 443150006286 PPE family; Region: PPE; pfam00823 443150006287 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150006288 PPE family; Region: PPE; pfam00823 443150006289 PPE family; Region: PPE; pfam00823 443150006290 glycyl-tRNA synthetase; Provisional; Region: PRK04173 443150006291 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 443150006292 motif 1; other site 443150006293 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 443150006294 active site 443150006295 motif 2; other site 443150006296 motif 3; other site 443150006297 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 443150006298 anticodon binding site; other site 443150006299 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443150006300 dimerization interface [polypeptide binding]; other site 443150006301 putative DNA binding site [nucleotide binding]; other site 443150006302 putative Zn2+ binding site [ion binding]; other site 443150006303 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 443150006304 metal binding site 2 [ion binding]; metal-binding site 443150006305 putative DNA binding helix; other site 443150006306 metal binding site 1 [ion binding]; metal-binding site 443150006307 dimer interface [polypeptide binding]; other site 443150006308 structural Zn2+ binding site [ion binding]; other site 443150006309 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 443150006310 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 443150006311 catalytic residue [active] 443150006312 putative FPP diphosphate binding site; other site 443150006313 putative FPP binding hydrophobic cleft; other site 443150006314 dimer interface [polypeptide binding]; other site 443150006315 putative IPP diphosphate binding site; other site 443150006316 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 443150006317 Recombination protein O N terminal; Region: RecO_N; pfam11967 443150006318 Recombination protein O C terminal; Region: RecO_C; pfam02565 443150006319 amidase; Provisional; Region: PRK06061 443150006320 Amidase; Region: Amidase; pfam01425 443150006321 GTPase Era; Reviewed; Region: era; PRK00089 443150006322 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 443150006323 G1 box; other site 443150006324 GTP/Mg2+ binding site [chemical binding]; other site 443150006325 Switch I region; other site 443150006326 G2 box; other site 443150006327 Switch II region; other site 443150006328 G3 box; other site 443150006329 G4 box; other site 443150006330 G5 box; other site 443150006331 KH domain; Region: KH_2; pfam07650 443150006332 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 443150006333 Domain of unknown function DUF21; Region: DUF21; pfam01595 443150006334 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 443150006335 Transporter associated domain; Region: CorC_HlyC; smart01091 443150006336 metal-binding heat shock protein; Provisional; Region: PRK00016 443150006337 K homology RNA-binding domain; Region: KH; smart00322 443150006338 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 443150006339 PhoH-like protein; Region: PhoH; pfam02562 443150006340 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 443150006341 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 443150006342 RNA methyltransferase, RsmE family; Region: TIGR00046 443150006343 chaperone protein DnaJ; Provisional; Region: PRK14278 443150006344 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 443150006345 HSP70 interaction site [polypeptide binding]; other site 443150006346 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 443150006347 Zn binding sites [ion binding]; other site 443150006348 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 443150006349 dimer interface [polypeptide binding]; other site 443150006350 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 443150006351 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 443150006352 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 443150006353 Condensation domain; Region: Condensation; pfam00668 443150006354 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 443150006355 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 443150006356 acyl-activating enzyme (AAE) consensus motif; other site 443150006357 AMP binding site [chemical binding]; other site 443150006358 Condensation domain; Region: Condensation; pfam00668 443150006359 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 443150006360 Condensation domain; Region: Condensation; pfam00668 443150006361 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 443150006362 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 443150006363 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 443150006364 acyl-activating enzyme (AAE) consensus motif; other site 443150006365 AMP binding site [chemical binding]; other site 443150006366 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 443150006367 Condensation domain; Region: Condensation; pfam00668 443150006368 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 443150006369 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 443150006370 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443150006371 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 443150006372 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 443150006373 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 443150006374 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 443150006375 NADP binding site [chemical binding]; other site 443150006376 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 443150006377 active site 443150006378 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 443150006379 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 443150006380 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 443150006381 active site 443150006382 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 443150006383 Condensation domain; Region: Condensation; pfam00668 443150006384 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 443150006385 Nonribosomal peptide synthase; Region: NRPS; pfam08415 443150006386 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 443150006387 acyl-activating enzyme (AAE) consensus motif; other site 443150006388 AMP binding site [chemical binding]; other site 443150006389 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 443150006390 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 443150006391 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 443150006392 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 443150006393 acyl-activating enzyme (AAE) consensus motif; other site 443150006394 active site 443150006395 AMP binding site [chemical binding]; other site 443150006396 substrate binding site [chemical binding]; other site 443150006397 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 443150006398 salicylate synthase MbtI; Reviewed; Region: PRK07912 443150006399 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 443150006400 Predicted permease [General function prediction only]; Region: COG3329 443150006401 coproporphyrinogen III oxidase; Validated; Region: PRK05628 443150006402 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 443150006403 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 443150006404 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 443150006405 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 443150006406 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 443150006407 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 443150006408 Active Sites [active] 443150006409 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 443150006410 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 443150006411 putative active site [active] 443150006412 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 443150006413 putative active site [active] 443150006414 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 443150006415 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 443150006416 Predicted membrane protein [Function unknown]; Region: COG1297 443150006417 putative oligopeptide transporter, OPT family; Region: TIGR00733 443150006418 PE family; Region: PE; pfam00934 443150006419 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 443150006420 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 443150006421 Walker A/P-loop; other site 443150006422 ATP binding site [chemical binding]; other site 443150006423 Q-loop/lid; other site 443150006424 ABC transporter signature motif; other site 443150006425 Walker B; other site 443150006426 D-loop; other site 443150006427 H-loop/switch region; other site 443150006428 sulfate transport protein; Provisional; Region: cysT; CHL00187 443150006429 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443150006430 dimer interface [polypeptide binding]; other site 443150006431 conserved gate region; other site 443150006432 putative PBP binding loops; other site 443150006433 ABC-ATPase subunit interface; other site 443150006434 sulfate transport protein; Provisional; Region: cysT; CHL00187 443150006435 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443150006436 dimer interface [polypeptide binding]; other site 443150006437 conserved gate region; other site 443150006438 putative PBP binding loops; other site 443150006439 ABC-ATPase subunit interface; other site 443150006440 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 443150006441 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 443150006442 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 443150006443 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 443150006444 PknH-like extracellular domain; Region: PknH_C; pfam14032 443150006445 GTP-binding protein LepA; Provisional; Region: PRK05433 443150006446 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 443150006447 G1 box; other site 443150006448 putative GEF interaction site [polypeptide binding]; other site 443150006449 GTP/Mg2+ binding site [chemical binding]; other site 443150006450 Switch I region; other site 443150006451 G2 box; other site 443150006452 G3 box; other site 443150006453 Switch II region; other site 443150006454 G4 box; other site 443150006455 G5 box; other site 443150006456 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 443150006457 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 443150006458 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 443150006459 PemK-like protein; Region: PemK; pfam02452 443150006460 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 443150006461 FOG: CBS domain [General function prediction only]; Region: COG0517 443150006462 ribonuclease Z; Reviewed; Region: PRK00055 443150006463 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 443150006464 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 443150006465 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 443150006466 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 443150006467 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 443150006468 Uncharacterized conserved protein [Function unknown]; Region: COG2308 443150006469 hypothetical protein; Reviewed; Region: PRK07914 443150006470 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 443150006471 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 443150006472 Competence protein; Region: Competence; pfam03772 443150006473 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 443150006474 Helix-hairpin-helix motif; Region: HHH; pfam00633 443150006475 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 443150006476 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443150006477 Coenzyme A binding pocket [chemical binding]; other site 443150006478 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 443150006479 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 443150006480 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 443150006481 active site 443150006482 catalytic triad [active] 443150006483 oxyanion hole [active] 443150006484 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 443150006485 catalytic core [active] 443150006486 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 443150006487 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 443150006488 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 443150006489 active site 443150006490 (T/H)XGH motif; other site 443150006491 Methyltransferase domain; Region: Methyltransf_23; pfam13489 443150006492 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443150006493 S-adenosylmethionine binding site [chemical binding]; other site 443150006494 Transposase; Region: DEDD_Tnp_IS110; pfam01548 443150006495 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 443150006496 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 443150006497 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 443150006498 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 443150006499 metal ion-dependent adhesion site (MIDAS); other site 443150006500 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 443150006501 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443150006502 Walker A motif; other site 443150006503 ATP binding site [chemical binding]; other site 443150006504 Walker B motif; other site 443150006505 arginine finger; other site 443150006506 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 443150006507 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 443150006508 putative catalytic cysteine [active] 443150006509 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 443150006510 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 443150006511 dimer interface [polypeptide binding]; other site 443150006512 decamer (pentamer of dimers) interface [polypeptide binding]; other site 443150006513 catalytic triad [active] 443150006514 peroxidatic and resolving cysteines [active] 443150006515 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 443150006516 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 443150006517 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150006518 PPE family; Region: PPE; pfam00823 443150006519 potential frameshift: common BLAST hit: gi|378772168|ref|YP_005171901.1| putative transmembrane protein 443150006520 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 443150006521 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 443150006522 ligand binding site [chemical binding]; other site 443150006523 flexible hinge region; other site 443150006524 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 443150006525 Mechanosensitive ion channel; Region: MS_channel; pfam00924 443150006526 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443150006527 dimerization interface [polypeptide binding]; other site 443150006528 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 443150006529 cyclase homology domain; Region: CHD; cd07302 443150006530 nucleotidyl binding site; other site 443150006531 metal binding site [ion binding]; metal-binding site 443150006532 dimer interface [polypeptide binding]; other site 443150006533 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 443150006534 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 443150006535 substrate binding site [chemical binding]; other site 443150006536 ATP binding site [chemical binding]; other site 443150006537 NAD synthetase; Reviewed; Region: nadE; PRK02628 443150006538 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 443150006539 multimer interface [polypeptide binding]; other site 443150006540 active site 443150006541 catalytic triad [active] 443150006542 protein interface 1 [polypeptide binding]; other site 443150006543 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 443150006544 homodimer interface [polypeptide binding]; other site 443150006545 NAD binding pocket [chemical binding]; other site 443150006546 ATP binding pocket [chemical binding]; other site 443150006547 Mg binding site [ion binding]; other site 443150006548 active-site loop [active] 443150006549 glutamate 5-kinase; Region: proB; TIGR01027 443150006550 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 443150006551 nucleotide binding site [chemical binding]; other site 443150006552 homotetrameric interface [polypeptide binding]; other site 443150006553 putative phosphate binding site [ion binding]; other site 443150006554 putative allosteric binding site; other site 443150006555 PUA domain; Region: PUA; pfam01472 443150006556 GTPase CgtA; Reviewed; Region: obgE; PRK12296 443150006557 GTP1/OBG; Region: GTP1_OBG; pfam01018 443150006558 Obg GTPase; Region: Obg; cd01898 443150006559 G1 box; other site 443150006560 GTP/Mg2+ binding site [chemical binding]; other site 443150006561 Switch I region; other site 443150006562 G2 box; other site 443150006563 G3 box; other site 443150006564 Switch II region; other site 443150006565 G4 box; other site 443150006566 G5 box; other site 443150006567 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 443150006568 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 443150006569 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 443150006570 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 443150006571 homodimer interface [polypeptide binding]; other site 443150006572 oligonucleotide binding site [chemical binding]; other site 443150006573 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 443150006574 active site 443150006575 multimer interface [polypeptide binding]; other site 443150006576 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 443150006577 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 443150006578 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 443150006579 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 443150006580 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 443150006581 active site 443150006582 HIGH motif; other site 443150006583 nucleotide binding site [chemical binding]; other site 443150006584 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 443150006585 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 443150006586 active site 443150006587 KMSKS motif; other site 443150006588 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 443150006589 tRNA binding surface [nucleotide binding]; other site 443150006590 anticodon binding site; other site 443150006591 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 443150006592 Uncharacterized conserved protein [Function unknown]; Region: COG3268 443150006593 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 443150006594 NAD(P) binding pocket [chemical binding]; other site 443150006595 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 443150006596 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 443150006597 GTP binding site; other site 443150006598 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 443150006599 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 443150006600 TPP-binding site [chemical binding]; other site 443150006601 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 443150006602 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 443150006603 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 443150006604 dimer interface [polypeptide binding]; other site 443150006605 PYR/PP interface [polypeptide binding]; other site 443150006606 TPP binding site [chemical binding]; other site 443150006607 substrate binding site [chemical binding]; other site 443150006608 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 443150006609 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 443150006610 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443150006611 Walker A motif; other site 443150006612 ATP binding site [chemical binding]; other site 443150006613 Walker B motif; other site 443150006614 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 443150006615 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 443150006616 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 443150006617 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443150006618 Major Facilitator Superfamily; Region: MFS_1; pfam07690 443150006619 putative substrate translocation pore; other site 443150006620 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443150006621 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 443150006622 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 443150006623 oligomer interface [polypeptide binding]; other site 443150006624 active site residues [active] 443150006625 Clp protease; Region: CLP_protease; pfam00574 443150006626 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 443150006627 oligomer interface [polypeptide binding]; other site 443150006628 active site residues [active] 443150006629 trigger factor; Provisional; Region: tig; PRK01490 443150006630 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 443150006631 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 443150006632 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 443150006633 Beta-lactamase; Region: Beta-lactamase; pfam00144 443150006634 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 443150006635 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 443150006636 putative DNA binding site [nucleotide binding]; other site 443150006637 catalytic residue [active] 443150006638 putative H2TH interface [polypeptide binding]; other site 443150006639 putative catalytic residues [active] 443150006640 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 443150006641 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 443150006642 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 443150006643 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 443150006644 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 443150006645 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 443150006646 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 443150006647 Zn binding site [ion binding]; other site 443150006648 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 443150006649 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 443150006650 active site 443150006651 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 443150006652 apolar tunnel; other site 443150006653 heme binding site [chemical binding]; other site 443150006654 dimerization interface [polypeptide binding]; other site 443150006655 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 443150006656 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 443150006657 active site 443150006658 catalytic site [active] 443150006659 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 443150006660 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 443150006661 active site 443150006662 NAD-specific glutamate dehydrogenase [Amino acid transport and metabolism]; Region: COG2902 443150006663 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 443150006664 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 443150006665 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 443150006666 ABC transporter; Region: ABC_tran_2; pfam12848 443150006667 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 443150006668 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 443150006669 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 443150006670 dimer interface [polypeptide binding]; other site 443150006671 ssDNA binding site [nucleotide binding]; other site 443150006672 tetramer (dimer of dimers) interface [polypeptide binding]; other site 443150006673 glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355 443150006674 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 443150006675 putative acyl-acceptor binding pocket; other site 443150006676 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 443150006677 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 443150006678 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 443150006679 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 443150006680 putative acyl-acceptor binding pocket; other site 443150006681 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443150006682 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443150006683 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 443150006684 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 443150006685 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 443150006686 enoyl-CoA hydratase; Provisional; Region: PRK05870 443150006687 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443150006688 substrate binding site [chemical binding]; other site 443150006689 oxyanion hole (OAH) forming residues; other site 443150006690 trimer interface [polypeptide binding]; other site 443150006691 PE family; Region: PE; pfam00934 443150006692 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 443150006693 cyclase homology domain; Region: CHD; cd07302 443150006694 nucleotidyl binding site; other site 443150006695 metal binding site [ion binding]; metal-binding site 443150006696 dimer interface [polypeptide binding]; other site 443150006697 AAA ATPase domain; Region: AAA_16; pfam13191 443150006698 Predicted ATPase [General function prediction only]; Region: COG3903 443150006699 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443150006700 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443150006701 DNA binding residues [nucleotide binding] 443150006702 dimerization interface [polypeptide binding]; other site 443150006703 PE family; Region: PE; pfam00934 443150006704 TIGR00725 family protein; Region: TIGR00725 443150006705 thymidylate synthase; Provisional; Region: thyA; PRK00956 443150006706 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 443150006707 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 443150006708 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 443150006709 E3 interaction surface; other site 443150006710 lipoyl attachment site [posttranslational modification]; other site 443150006711 e3 binding domain; Region: E3_binding; pfam02817 443150006712 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 443150006713 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 443150006714 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 443150006715 alpha subunit interface [polypeptide binding]; other site 443150006716 TPP binding site [chemical binding]; other site 443150006717 heterodimer interface [polypeptide binding]; other site 443150006718 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 443150006719 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 443150006720 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 443150006721 tetramer interface [polypeptide binding]; other site 443150006722 TPP-binding site [chemical binding]; other site 443150006723 heterodimer interface [polypeptide binding]; other site 443150006724 phosphorylation loop region [posttranslational modification] 443150006725 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 443150006726 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 443150006727 putative active site [active] 443150006728 putative catalytic site [active] 443150006729 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443150006730 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443150006731 active site 443150006732 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 443150006733 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 443150006734 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 443150006735 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 443150006736 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 443150006737 carboxyltransferase (CT) interaction site; other site 443150006738 biotinylation site [posttranslational modification]; other site 443150006739 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 443150006740 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 443150006741 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 443150006742 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 443150006743 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 443150006744 AMP-binding domain protein; Validated; Region: PRK08315 443150006745 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443150006746 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 443150006747 acyl-activating enzyme (AAE) consensus motif; other site 443150006748 acyl-activating enzyme (AAE) consensus motif; other site 443150006749 putative AMP binding site [chemical binding]; other site 443150006750 putative active site [active] 443150006751 putative CoA binding site [chemical binding]; other site 443150006752 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443150006753 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443150006754 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 443150006755 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 443150006756 classical (c) SDRs; Region: SDR_c; cd05233 443150006757 NAD(P) binding site [chemical binding]; other site 443150006758 active site 443150006759 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 443150006760 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 443150006761 catalytic site [active] 443150006762 putative active site [active] 443150006763 putative substrate binding site [chemical binding]; other site 443150006764 dimer interface [polypeptide binding]; other site 443150006765 Transposase, Mutator family; Region: Transposase_mut; pfam00872 443150006766 MULE transposase domain; Region: MULE; pfam10551 443150006767 Domain of unknown function (DUF4411); Region: DUF4411; pfam14367 443150006768 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443150006769 non-specific DNA binding site [nucleotide binding]; other site 443150006770 salt bridge; other site 443150006771 sequence-specific DNA binding site [nucleotide binding]; other site 443150006772 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 443150006773 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893 443150006774 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 443150006775 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 443150006776 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 443150006777 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 443150006778 PE family; Region: PE; pfam00934 443150006779 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 443150006780 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 443150006781 catalytic triad [active] 443150006782 hypothetical protein; Provisional; Region: PRK07907 443150006783 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 443150006784 active site 443150006785 metal binding site [ion binding]; metal-binding site 443150006786 dimer interface [polypeptide binding]; other site 443150006787 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 443150006788 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 443150006789 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 443150006790 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 443150006791 phosphate binding site [ion binding]; other site 443150006792 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 443150006793 FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447 443150006794 putative active site [active] 443150006795 putative catalytic site [active] 443150006796 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 443150006797 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 443150006798 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 443150006799 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 443150006800 putative NAD(P) binding site [chemical binding]; other site 443150006801 active site 443150006802 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 443150006803 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 443150006804 active site 443150006805 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 443150006806 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 443150006807 putative active site [active] 443150006808 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 443150006809 Mrr N-terminal domain; Region: Mrr_N; pfam14338 443150006810 Restriction endonuclease; Region: Mrr_cat; pfam04471 443150006811 ERCC4 domain; Region: ERCC4; pfam02732 443150006812 Lsr2; Region: Lsr2; pfam11774 443150006813 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 443150006814 putative active site [active] 443150006815 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 443150006816 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 443150006817 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443150006818 catalytic residue [active] 443150006819 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 443150006820 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 443150006821 elongation factor P; Validated; Region: PRK00529 443150006822 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 443150006823 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 443150006824 RNA binding site [nucleotide binding]; other site 443150006825 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 443150006826 RNA binding site [nucleotide binding]; other site 443150006827 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 443150006828 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 443150006829 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 443150006830 active site 443150006831 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 443150006832 Dehydroquinase class II; Region: DHquinase_II; pfam01220 443150006833 trimer interface [polypeptide binding]; other site 443150006834 active site 443150006835 dimer interface [polypeptide binding]; other site 443150006836 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 443150006837 active site 443150006838 dimer interface [polypeptide binding]; other site 443150006839 metal binding site [ion binding]; metal-binding site 443150006840 shikimate kinase; Reviewed; Region: aroK; PRK00131 443150006841 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 443150006842 ADP binding site [chemical binding]; other site 443150006843 magnesium binding site [ion binding]; other site 443150006844 putative shikimate binding site; other site 443150006845 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 443150006846 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 443150006847 Tetramer interface [polypeptide binding]; other site 443150006848 active site 443150006849 FMN-binding site [chemical binding]; other site 443150006850 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 443150006851 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 443150006852 putative active site [active] 443150006853 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 443150006854 oligomeric interface; other site 443150006855 putative active site [active] 443150006856 homodimer interface [polypeptide binding]; other site 443150006857 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402 443150006858 putative active site [active] 443150006859 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 443150006860 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 443150006861 shikimate-5-dehydrogenase, fungal AROM-type; Region: Shik-DH-AROM; TIGR01809 443150006862 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 443150006863 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 443150006864 NAD(P) binding site [chemical binding]; other site 443150006865 shikimate binding site; other site 443150006866 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 443150006867 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 443150006868 dimerization interface [polypeptide binding]; other site 443150006869 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 443150006870 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 443150006871 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 443150006872 motif 1; other site 443150006873 active site 443150006874 motif 2; other site 443150006875 motif 3; other site 443150006876 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 443150006877 DHHA1 domain; Region: DHHA1; pfam02272 443150006878 Uncharacterized conserved protein [Function unknown]; Region: COG0432 443150006879 recombination factor protein RarA; Reviewed; Region: PRK13342 443150006880 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443150006881 Walker A motif; other site 443150006882 ATP binding site [chemical binding]; other site 443150006883 Walker B motif; other site 443150006884 arginine finger; other site 443150006885 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 443150006886 Predicted integral membrane protein [Function unknown]; Region: COG5473 443150006887 Protein of unknown function (DUF2652); Region: DUF2652; pfam10851 443150006888 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 443150006889 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 443150006890 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 443150006891 Walker A/P-loop; other site 443150006892 ATP binding site [chemical binding]; other site 443150006893 Q-loop/lid; other site 443150006894 ABC transporter signature motif; other site 443150006895 Walker B; other site 443150006896 D-loop; other site 443150006897 H-loop/switch region; other site 443150006898 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 443150006899 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 443150006900 ligand binding site [chemical binding]; other site 443150006901 flexible hinge region; other site 443150006902 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 443150006903 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 443150006904 ligand binding site [chemical binding]; other site 443150006905 flexible hinge region; other site 443150006906 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 443150006907 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 443150006908 active site 443150006909 nucleophile elbow; other site 443150006910 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 443150006911 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 443150006912 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 443150006913 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 443150006914 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 443150006915 Uncharacterized conserved protein [Function unknown]; Region: COG2308 443150006916 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 443150006917 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 443150006918 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 443150006919 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 443150006920 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 443150006921 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 443150006922 Transglutaminase/protease-like homologues; Region: TGc; smart00460 443150006923 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3801 443150006924 Predicted membrane protein [Function unknown]; Region: COG4129 443150006925 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 443150006926 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 443150006927 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 443150006928 dimer interface [polypeptide binding]; other site 443150006929 anticodon binding site; other site 443150006930 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 443150006931 homodimer interface [polypeptide binding]; other site 443150006932 motif 1; other site 443150006933 active site 443150006934 motif 2; other site 443150006935 GAD domain; Region: GAD; pfam02938 443150006936 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 443150006937 active site 443150006938 motif 3; other site 443150006939 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 443150006940 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 443150006941 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 443150006942 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 443150006943 putative hydrophobic ligand binding site [chemical binding]; other site 443150006944 protein interface [polypeptide binding]; other site 443150006945 gate; other site 443150006946 Predicted metalloprotease [General function prediction only]; Region: COG2321 443150006947 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 443150006948 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 443150006949 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 443150006950 active site 443150006951 metal binding site [ion binding]; metal-binding site 443150006952 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 443150006953 haloalkane dehalogenase; Provisional; Region: PRK03592 443150006954 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 443150006955 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 443150006956 dimer interface [polypeptide binding]; other site 443150006957 motif 1; other site 443150006958 active site 443150006959 motif 2; other site 443150006960 motif 3; other site 443150006961 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 443150006962 anticodon binding site; other site 443150006963 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 443150006964 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 443150006965 active site 443150006966 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 443150006967 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443150006968 Zn2+ binding site [ion binding]; other site 443150006969 Mg2+ binding site [ion binding]; other site 443150006970 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 443150006971 synthetase active site [active] 443150006972 NTP binding site [chemical binding]; other site 443150006973 metal binding site [ion binding]; metal-binding site 443150006974 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 443150006975 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 443150006976 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 443150006977 active site 443150006978 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 443150006979 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 443150006980 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 443150006981 Protein export membrane protein; Region: SecD_SecF; pfam02355 443150006982 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 443150006983 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 443150006984 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05886 443150006985 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 443150006986 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 443150006987 inhibitor-cofactor binding pocket; inhibition site 443150006988 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443150006989 catalytic residue [active] 443150006990 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 443150006991 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443150006992 acyl-activating enzyme (AAE) consensus motif; other site 443150006993 AMP binding site [chemical binding]; other site 443150006994 active site 443150006995 CoA binding site [chemical binding]; other site 443150006996 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 443150006997 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 443150006998 putative NAD(P) binding site [chemical binding]; other site 443150006999 active site 443150007000 putative substrate binding site [chemical binding]; other site 443150007001 PE family; Region: PE; pfam00934 443150007002 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 443150007003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443150007004 ATP binding site [chemical binding]; other site 443150007005 Walker B motif; other site 443150007006 arginine finger; other site 443150007007 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 443150007008 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 443150007009 RuvA N terminal domain; Region: RuvA_N; pfam01330 443150007010 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 443150007011 active site 443150007012 putative DNA-binding cleft [nucleotide binding]; other site 443150007013 dimer interface [polypeptide binding]; other site 443150007014 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 443150007015 putative active site [active] 443150007016 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 443150007017 Protein of unknown function DUF2617; Region: DUF2617; pfam10936 443150007018 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 443150007019 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 443150007020 Spermine/spermidine synthase; Region: Spermine_synth; pfam01564 443150007021 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 443150007022 hypothetical protein; Validated; Region: PRK00110 443150007023 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 443150007024 predicted active site [active] 443150007025 catalytic triad [active] 443150007026 acyl-CoA thioesterase II; Region: tesB; TIGR00189 443150007027 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 443150007028 active site 443150007029 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 443150007030 catalytic triad [active] 443150007031 dimer interface [polypeptide binding]; other site 443150007032 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 443150007033 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 443150007034 active site 443150007035 multimer interface [polypeptide binding]; other site 443150007036 Pyridoxamine-phosphate oxidase [Coenzyme metabolism]; Region: PdxH; COG0259 443150007037 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 443150007038 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 443150007039 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150007040 PPE family; Region: PPE; pfam00823 443150007041 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150007042 PE-PPE domain; Region: PE-PPE; pfam08237 443150007043 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 443150007044 nudix motif; other site 443150007045 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443150007046 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 443150007047 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 443150007048 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 443150007049 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 443150007050 putative acyl-acceptor binding pocket; other site 443150007051 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 443150007052 nucleotide binding site/active site [active] 443150007053 HIT family signature motif; other site 443150007054 catalytic residue [active] 443150007055 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 443150007056 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 443150007057 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 443150007058 active site 443150007059 dimer interface [polypeptide binding]; other site 443150007060 motif 1; other site 443150007061 motif 2; other site 443150007062 motif 3; other site 443150007063 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 443150007064 anticodon binding site; other site 443150007065 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4762 443150007066 Helix-turn-helix domain; Region: HTH_20; pfam12840 443150007067 Predicted transcriptional regulator [Transcription]; Region: COG2345 443150007068 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 443150007069 Predicted transcriptional regulator [Transcription]; Region: COG2345 443150007070 Helix-turn-helix domain; Region: HTH_20; pfam12840 443150007071 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443150007072 S-adenosylmethionine binding site [chemical binding]; other site 443150007073 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 443150007074 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 443150007075 Ligand Binding Site [chemical binding]; other site 443150007076 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 443150007077 Ligand Binding Site [chemical binding]; other site 443150007078 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 443150007079 Ligand Binding Site [chemical binding]; other site 443150007080 Universal stress protein family; Region: Usp; pfam00582 443150007081 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 443150007082 active site 443150007083 Peptidase family M50; Region: Peptidase_M50; pfam02163 443150007084 putative substrate binding region [chemical binding]; other site 443150007085 FOG: CBS domain [General function prediction only]; Region: COG0517 443150007086 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 443150007087 FOG: CBS domain [General function prediction only]; Region: COG0517 443150007088 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 443150007089 peptide chain release factor 1; Provisional; Region: PRK04011 443150007090 Archease protein family (MTH1598/TM1083); Region: Archease; cl00606 443150007091 Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690 443150007092 hypothetical protein; Reviewed; Region: PRK09588 443150007093 Hemerythrin-like domain; Region: Hr-like; cd12108 443150007094 Fe binding site [ion binding]; other site 443150007095 PE family; Region: PE; pfam00934 443150007096 Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cd00227 443150007097 P-loop motif; other site 443150007098 ATP binding site [chemical binding]; other site 443150007099 Chloramphenicol (Cm) binding site [chemical binding]; other site 443150007100 catalytic residue [active] 443150007101 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 443150007102 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 443150007103 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 443150007104 anti sigma factor interaction site; other site 443150007105 regulatory phosphorylation site [posttranslational modification]; other site 443150007106 hypothetical protein; Provisional; Region: PRK02237 443150007107 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443150007108 Transcriptional regulators [Transcription]; Region: MarR; COG1846 443150007109 putative DNA binding site [nucleotide binding]; other site 443150007110 putative Zn2+ binding site [ion binding]; other site 443150007111 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 443150007112 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443150007113 putative metal binding site [ion binding]; other site 443150007114 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443150007115 dimerization interface [polypeptide binding]; other site 443150007116 putative DNA binding site [nucleotide binding]; other site 443150007117 putative Zn2+ binding site [ion binding]; other site 443150007118 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 443150007119 arsenical-resistance protein; Region: acr3; TIGR00832 443150007120 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 443150007121 Low molecular weight phosphatase family; Region: LMWPc; cd00115 443150007122 active site 443150007123 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 443150007124 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 443150007125 active site 443150007126 DNA binding site [nucleotide binding] 443150007127 Int/Topo IB signature motif; other site 443150007128 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 443150007129 ParB-like nuclease domain; Region: ParBc; cl02129 443150007130 Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653 443150007131 Phage capsid family; Region: Phage_capsid; pfam05065 443150007132 phage prohead protease, HK97 family; Region: proheadase_HK97; TIGR01543 443150007133 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: COG3747 443150007134 Protein of unknown function (DUF3631); Region: DUF3631; pfam12307 443150007135 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 443150007136 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 443150007137 active site 443150007138 catalytic residues [active] 443150007139 DNA binding site [nucleotide binding] 443150007140 Int/Topo IB signature motif; other site 443150007141 Transposase, Mutator family; Region: Transposase_mut; pfam00872 443150007142 MULE transposase domain; Region: MULE; pfam10551 443150007143 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 443150007144 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 443150007145 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443150007146 Coenzyme A binding pocket [chemical binding]; other site 443150007147 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 443150007148 hypothetical protein; Provisional; Region: PRK14059 443150007149 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 443150007150 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443150007151 TAP-like protein; Region: Abhydrolase_4; pfam08386 443150007152 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 443150007153 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 443150007154 SelR domain; Region: SelR; pfam01641 443150007155 Methyltransferase domain; Region: Methyltransf_31; pfam13847 443150007156 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443150007157 S-adenosylmethionine binding site [chemical binding]; other site 443150007158 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 443150007159 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 443150007160 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 443150007161 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 443150007162 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 443150007163 substrate binding site [chemical binding]; other site 443150007164 active site 443150007165 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443150007166 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 443150007167 substrate binding site [chemical binding]; other site 443150007168 oxyanion hole (OAH) forming residues; other site 443150007169 trimer interface [polypeptide binding]; other site 443150007170 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 443150007171 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 443150007172 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 443150007173 catalytic site [active] 443150007174 putative active site [active] 443150007175 putative substrate binding site [chemical binding]; other site 443150007176 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 443150007177 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 443150007178 TPP-binding site; other site 443150007179 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 443150007180 PYR/PP interface [polypeptide binding]; other site 443150007181 dimer interface [polypeptide binding]; other site 443150007182 TPP binding site [chemical binding]; other site 443150007183 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 443150007184 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 443150007185 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 443150007186 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 443150007187 transmembrane helices; other site 443150007188 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 443150007189 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 443150007190 transmembrane helices; other site 443150007191 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 443150007192 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 443150007193 Walker A/P-loop; other site 443150007194 ATP binding site [chemical binding]; other site 443150007195 Q-loop/lid; other site 443150007196 ABC transporter signature motif; other site 443150007197 Walker B; other site 443150007198 D-loop; other site 443150007199 H-loop/switch region; other site 443150007200 TRAM domain; Region: TRAM; cl01282 443150007201 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 443150007202 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 443150007203 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 443150007204 TrkA-N domain; Region: TrkA_N; pfam02254 443150007205 TrkA-C domain; Region: TrkA_C; pfam02080 443150007206 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 443150007207 TrkA-N domain; Region: TrkA_N; pfam02254 443150007208 TrkA-C domain; Region: TrkA_C; pfam02080 443150007209 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 443150007210 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 443150007211 generic binding surface II; other site 443150007212 ssDNA binding site; other site 443150007213 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 443150007214 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 443150007215 trimer interface [polypeptide binding]; other site 443150007216 active site 443150007217 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 443150007218 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 443150007219 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 443150007220 active site 443150007221 dimerization interface [polypeptide binding]; other site 443150007222 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 443150007223 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 443150007224 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 443150007225 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443150007226 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 443150007227 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443150007228 DNA binding residues [nucleotide binding] 443150007229 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 443150007230 homotrimer interaction site [polypeptide binding]; other site 443150007231 putative active site [active] 443150007232 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 443150007233 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 443150007234 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 443150007235 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 443150007236 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443150007237 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 443150007238 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443150007239 DNA binding residues [nucleotide binding] 443150007240 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 443150007241 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 443150007242 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 443150007243 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 443150007244 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 443150007245 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 443150007246 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 443150007247 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443150007248 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 443150007249 PAC2 family; Region: PAC2; pfam09754 443150007250 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443150007251 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 443150007252 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 443150007253 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 443150007254 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 443150007255 heme-binding site [chemical binding]; other site 443150007256 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 443150007257 ATP cone domain; Region: ATP-cone; pfam03477 443150007258 LexA repressor; Validated; Region: PRK00215 443150007259 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 443150007260 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 443150007261 Catalytic site [active] 443150007262 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 443150007263 LGFP repeat; Region: LGFP; pfam08310 443150007264 LGFP repeat; Region: LGFP; pfam08310 443150007265 LGFP repeat; Region: LGFP; pfam08310 443150007266 LGFP repeat; Region: LGFP; pfam08310 443150007267 LGFP repeat; Region: LGFP; pfam08310 443150007268 Integral membrane protein TerC family; Region: TerC; cl10468 443150007269 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443150007270 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443150007271 active site 443150007272 GTPases [General function prediction only]; Region: HflX; COG2262 443150007273 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 443150007274 HflX GTPase family; Region: HflX; cd01878 443150007275 G1 box; other site 443150007276 GTP/Mg2+ binding site [chemical binding]; other site 443150007277 Switch I region; other site 443150007278 G2 box; other site 443150007279 G3 box; other site 443150007280 Switch II region; other site 443150007281 G4 box; other site 443150007282 G5 box; other site 443150007283 diaminopimelate epimerase; Region: DapF; TIGR00652 443150007284 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 443150007285 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 443150007286 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 443150007287 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 443150007288 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 443150007289 active site 443150007290 metal binding site [ion binding]; metal-binding site 443150007291 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 443150007292 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 443150007293 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 443150007294 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 443150007295 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443150007296 FeS/SAM binding site; other site 443150007297 TRAM domain; Region: TRAM; cl01282 443150007298 Uncharacterized protein conserved in bacteria [General function prediction only]; Region: OraA; COG2137 443150007299 DNA recombination protein RecA; Reviewed; Region: recA; PRK09519 443150007300 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 443150007301 hexamer interface [polypeptide binding]; other site 443150007302 Walker A motif; other site 443150007303 ATP binding site [chemical binding]; other site 443150007304 Walker B motif; other site 443150007305 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 443150007306 protein-splicing catalytic site; other site 443150007307 thioester formation/cholesterol transfer; other site 443150007308 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 443150007309 recA bacterial DNA recombination protein; Region: RecA; cl17211 443150007310 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 443150007311 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 443150007312 Limonene-1,2-epoxide hydrolase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LimA; COG4308 443150007313 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 443150007314 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443150007315 non-specific DNA binding site [nucleotide binding]; other site 443150007316 salt bridge; other site 443150007317 sequence-specific DNA binding site [nucleotide binding]; other site 443150007318 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 443150007319 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443150007320 Coenzyme A binding pocket [chemical binding]; other site 443150007321 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 443150007322 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 443150007323 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 443150007324 Uncharacterized conserved protein [Function unknown]; Region: COG1359 443150007325 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 443150007326 classical (c) SDRs; Region: SDR_c; cd05233 443150007327 NAD(P) binding site [chemical binding]; other site 443150007328 active site 443150007329 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 443150007330 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 443150007331 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 443150007332 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 443150007333 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 443150007334 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 443150007335 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 443150007336 dimer interface [polypeptide binding]; other site 443150007337 active site 443150007338 catalytic residue [active] 443150007339 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 443150007340 HsdM N-terminal domain; Region: HsdM_N; pfam12161 443150007341 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 443150007342 Methyltransferase domain; Region: Methyltransf_26; pfam13659 443150007343 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 443150007344 putative active site [active] 443150007345 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 443150007346 putative active site [active] 443150007347 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 443150007348 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 443150007349 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 443150007350 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 443150007351 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 443150007352 folate binding site [chemical binding]; other site 443150007353 NADP+ binding site [chemical binding]; other site 443150007354 thymidylate synthase; Reviewed; Region: thyA; PRK01827 443150007355 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 443150007356 dimerization interface [polypeptide binding]; other site 443150007357 active site 443150007358 Dienelactone hydrolase family; Region: DLH; pfam01738 443150007359 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 443150007360 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 443150007361 classical (c) SDRs; Region: SDR_c; cd05233 443150007362 NAD(P) binding site [chemical binding]; other site 443150007363 active site 443150007364 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150007365 PPE family; Region: PPE; pfam00823 443150007366 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 443150007367 PE family; Region: PE; pfam00934 443150007368 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 443150007369 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150007370 PPE family; Region: PPE; pfam00823 443150007371 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 443150007372 dihydrodipicolinate reductase; Provisional; Region: PRK00048 443150007373 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 443150007374 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 443150007375 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 443150007376 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443150007377 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 443150007378 Coenzyme A binding pocket [chemical binding]; other site 443150007379 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 443150007380 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 443150007381 FMN-binding pocket [chemical binding]; other site 443150007382 flavin binding motif; other site 443150007383 phosphate binding motif [ion binding]; other site 443150007384 beta-alpha-beta structure motif; other site 443150007385 NAD binding pocket [chemical binding]; other site 443150007386 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443150007387 catalytic loop [active] 443150007388 iron binding site [ion binding]; other site 443150007389 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 443150007390 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 443150007391 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 443150007392 hydrophobic ligand binding site; other site 443150007393 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 443150007394 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 443150007395 AsnC family; Region: AsnC_trans_reg; pfam01037 443150007396 potential frameshift: common BLAST hit: gi|383308538|ref|YP_005361349.1| alanine dehydrogenase 443150007397 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 443150007398 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 443150007399 Nitronate monooxygenase; Region: NMO; pfam03060 443150007400 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 443150007401 FMN binding site [chemical binding]; other site 443150007402 substrate binding site [chemical binding]; other site 443150007403 putative catalytic residue [active] 443150007404 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 443150007405 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 443150007406 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 443150007407 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 443150007408 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 443150007409 oligomer interface [polypeptide binding]; other site 443150007410 RNA binding site [nucleotide binding]; other site 443150007411 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 443150007412 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 443150007413 RNase E interface [polypeptide binding]; other site 443150007414 trimer interface [polypeptide binding]; other site 443150007415 active site 443150007416 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 443150007417 putative nucleic acid binding region [nucleotide binding]; other site 443150007418 G-X-X-G motif; other site 443150007419 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 443150007420 RNA binding site [nucleotide binding]; other site 443150007421 domain interface; other site 443150007422 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 443150007423 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 443150007424 active site 443150007425 Riboflavin kinase; Region: Flavokinase; pfam01687 443150007426 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 443150007427 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 443150007428 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 443150007429 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443150007430 putative DNA binding site [nucleotide binding]; other site 443150007431 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 443150007432 FeoA domain; Region: FeoA; pfam04023 443150007433 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443150007434 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443150007435 active site 443150007436 lipid-transfer protein; Provisional; Region: PRK08256 443150007437 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 443150007438 active site 443150007439 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 443150007440 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 443150007441 Probable transposase; Region: OrfB_IS605; pfam01385 443150007442 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 443150007443 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 443150007444 catalytic residues [active] 443150007445 catalytic nucleophile [active] 443150007446 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 443150007447 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 443150007448 RNA binding site [nucleotide binding]; other site 443150007449 active site 443150007450 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 443150007451 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 443150007452 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 443150007453 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 443150007454 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 443150007455 active site 443150007456 metal binding site [ion binding]; metal-binding site 443150007457 Uncharacterized conserved protein [Function unknown]; Region: COG4717 443150007458 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 443150007459 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 443150007460 Predicted acyl esterases [General function prediction only]; Region: COG2936 443150007461 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 443150007462 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 443150007463 Uncharacterized conserved protein [Function unknown]; Region: COG5586 443150007464 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 443150007465 Integrase core domain; Region: rve; pfam00665 443150007466 Helix-turn-helix domain; Region: HTH_28; pfam13518 443150007467 Winged helix-turn helix; Region: HTH_29; pfam13551 443150007468 Integrase core domain; Region: rve; pfam00665 443150007469 Integrase core domain; Region: rve_3; pfam13683 443150007470 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 443150007471 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 443150007472 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 443150007473 Transposase; Region: HTH_Tnp_1; cl17663 443150007474 putative transposase OrfB; Reviewed; Region: PHA02517 443150007475 HTH-like domain; Region: HTH_21; pfam13276 443150007476 Integrase core domain; Region: rve; pfam00665 443150007477 Integrase core domain; Region: rve_3; pfam13683 443150007478 CRISPR/Cas system-associated RAMP superfamily protein Csm3; Region: Csm3_III-A; cd09684 443150007479 CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cd09647 443150007480 Predicted CRISPR-associated polymerase [Defense mechanisms]; Region: COG1353 443150007481 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 443150007482 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 443150007483 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4293 443150007484 Uncharacterized conserved protein [Function unknown]; Region: COG2253 443150007485 Protein of unknown function (DUF2005); Region: DUF2005; pfam09407 443150007486 Domain of unknown function (DUF1802); Region: DUF1802; cl01755 443150007487 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 443150007488 putative active site [active] 443150007489 enoyl-CoA hydratase; Provisional; Region: PRK06190 443150007490 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443150007491 substrate binding site [chemical binding]; other site 443150007492 oxyanion hole (OAH) forming residues; other site 443150007493 trimer interface [polypeptide binding]; other site 443150007494 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 443150007495 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 443150007496 Walker A/P-loop; other site 443150007497 ATP binding site [chemical binding]; other site 443150007498 Q-loop/lid; other site 443150007499 ABC transporter signature motif; other site 443150007500 Walker B; other site 443150007501 D-loop; other site 443150007502 H-loop/switch region; other site 443150007503 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 443150007504 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 443150007505 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 443150007506 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443150007507 dimer interface [polypeptide binding]; other site 443150007508 conserved gate region; other site 443150007509 putative PBP binding loops; other site 443150007510 ABC-ATPase subunit interface; other site 443150007511 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 443150007512 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443150007513 dimer interface [polypeptide binding]; other site 443150007514 conserved gate region; other site 443150007515 putative PBP binding loops; other site 443150007516 ABC-ATPase subunit interface; other site 443150007517 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 443150007518 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 443150007519 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 443150007520 DHH family; Region: DHH; pfam01368 443150007521 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 443150007522 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 443150007523 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 443150007524 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 443150007525 G1 box; other site 443150007526 putative GEF interaction site [polypeptide binding]; other site 443150007527 GTP/Mg2+ binding site [chemical binding]; other site 443150007528 Switch I region; other site 443150007529 G2 box; other site 443150007530 G3 box; other site 443150007531 Switch II region; other site 443150007532 G4 box; other site 443150007533 G5 box; other site 443150007534 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 443150007535 Translation-initiation factor 2; Region: IF-2; pfam11987 443150007536 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 443150007537 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 443150007538 NusA N-terminal domain; Region: NusA_N; pfam08529 443150007539 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 443150007540 RNA binding site [nucleotide binding]; other site 443150007541 homodimer interface [polypeptide binding]; other site 443150007542 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 443150007543 G-X-X-G motif; other site 443150007544 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 443150007545 G-X-X-G motif; other site 443150007546 ribosome maturation protein RimP; Reviewed; Region: PRK00092 443150007547 Sm and related proteins; Region: Sm_like; cl00259 443150007548 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 443150007549 putative oligomer interface [polypeptide binding]; other site 443150007550 putative RNA binding site [nucleotide binding]; other site 443150007551 Mitochondrial ATP synthase g subunit; Region: ATP-synt_G; pfam04718 443150007552 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 443150007553 dinuclear metal binding motif [ion binding]; other site 443150007554 prolyl-tRNA synthetase; Provisional; Region: PRK09194 443150007555 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 443150007556 dimer interface [polypeptide binding]; other site 443150007557 motif 1; other site 443150007558 active site 443150007559 motif 2; other site 443150007560 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 443150007561 putative deacylase active site [active] 443150007562 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 443150007563 active site 443150007564 motif 3; other site 443150007565 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 443150007566 anticodon binding site; other site 443150007567 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443150007568 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 443150007569 putative substrate translocation pore; other site 443150007570 Putative NAD(P)-binding; Region: NAD_binding_7; cl17660 443150007571 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 443150007572 homodimer interface [polypeptide binding]; other site 443150007573 active site 443150007574 SAM binding site [chemical binding]; other site 443150007575 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 443150007576 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 443150007577 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 443150007578 catalytic triad [active] 443150007579 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 443150007580 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 443150007581 homodimer interface [polypeptide binding]; other site 443150007582 Walker A motif; other site 443150007583 ATP binding site [chemical binding]; other site 443150007584 hydroxycobalamin binding site [chemical binding]; other site 443150007585 Walker B motif; other site 443150007586 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 443150007587 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443150007588 Walker A motif; other site 443150007589 ATP binding site [chemical binding]; other site 443150007590 Walker B motif; other site 443150007591 arginine finger; other site 443150007592 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 443150007593 metal ion-dependent adhesion site (MIDAS); other site 443150007594 Predicted acyltransferase [General function prediction only]; Region: ElaA; COG2153 443150007595 malate:quinone oxidoreductase; Validated; Region: PRK05257 443150007596 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 443150007597 PE family; Region: PE; pfam00934 443150007598 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 443150007599 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 443150007600 mycothione reductase; Reviewed; Region: PRK07846 443150007601 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 443150007602 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443150007603 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 443150007604 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 443150007605 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 443150007606 short chain dehydrogenase; Provisional; Region: PRK06057 443150007607 classical (c) SDRs; Region: SDR_c; cd05233 443150007608 NAD(P) binding site [chemical binding]; other site 443150007609 active site 443150007610 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 443150007611 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 443150007612 NAD(P) binding site [chemical binding]; other site 443150007613 catalytic residues [active] 443150007614 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 443150007615 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 443150007616 catalytic triad [active] 443150007617 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 443150007618 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 443150007619 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 443150007620 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 443150007621 active site 443150007622 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 443150007623 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 443150007624 putative active site [active] 443150007625 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 443150007626 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 443150007627 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 443150007628 Predicted acetyltransferase [General function prediction only]; Region: COG3393 443150007629 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 443150007630 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 443150007631 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 443150007632 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 443150007633 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 443150007634 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 443150007635 active site 443150007636 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 443150007637 protein binding site [polypeptide binding]; other site 443150007638 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 443150007639 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 443150007640 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 443150007641 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 443150007642 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 443150007643 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 443150007644 Fasciclin domain; Region: Fasciclin; pfam02469 443150007645 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 443150007646 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 443150007647 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 443150007648 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 443150007649 catalytic residues [active] 443150007650 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 443150007651 Fasciclin domain; Region: Fasciclin; pfam02469 443150007652 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 443150007653 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 443150007654 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 443150007655 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 443150007656 catalytic residues [active] 443150007657 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 443150007658 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443150007659 FeS/SAM binding site; other site 443150007660 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 443150007661 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 443150007662 ribosome recycling factor; Reviewed; Region: frr; PRK00083 443150007663 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 443150007664 hinge region; other site 443150007665 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 443150007666 putative nucleotide binding site [chemical binding]; other site 443150007667 uridine monophosphate binding site [chemical binding]; other site 443150007668 homohexameric interface [polypeptide binding]; other site 443150007669 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 443150007670 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443150007671 DNA binding site [nucleotide binding] 443150007672 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 443150007673 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 443150007674 Probable transposase; Region: OrfB_IS605; pfam01385 443150007675 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 443150007676 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 443150007677 catalytic residues [active] 443150007678 catalytic nucleophile [active] 443150007679 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 443150007680 MarR family; Region: MarR; pfam01047 443150007681 amidase; Provisional; Region: PRK07869 443150007682 Amidase; Region: Amidase; pfam01425 443150007683 elongation factor Ts; Provisional; Region: tsf; PRK09377 443150007684 UBA/TS-N domain; Region: UBA; pfam00627 443150007685 Elongation factor TS; Region: EF_TS; pfam00889 443150007686 Elongation factor TS; Region: EF_TS; pfam00889 443150007687 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 443150007688 rRNA interaction site [nucleotide binding]; other site 443150007689 S8 interaction site; other site 443150007690 putative laminin-1 binding site; other site 443150007691 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150007692 PPE family; Region: PPE; pfam00823 443150007693 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 443150007694 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 443150007695 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 443150007696 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 443150007697 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 443150007698 active site 443150007699 DNA binding site [nucleotide binding] 443150007700 Int/Topo IB signature motif; other site 443150007701 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 443150007702 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 443150007703 FAD binding pocket [chemical binding]; other site 443150007704 FAD binding motif [chemical binding]; other site 443150007705 phosphate binding motif [ion binding]; other site 443150007706 NAD binding pocket [chemical binding]; other site 443150007707 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 443150007708 DNA protecting protein DprA; Region: dprA; TIGR00732 443150007709 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 443150007710 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 443150007711 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443150007712 Walker A motif; other site 443150007713 ATP binding site [chemical binding]; other site 443150007714 Walker B motif; other site 443150007715 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 443150007716 hypothetical protein; Reviewed; Region: PRK12497 443150007717 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 443150007718 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 443150007719 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 443150007720 putative molybdopterin cofactor binding site [chemical binding]; other site 443150007721 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 443150007722 putative molybdopterin cofactor binding site; other site 443150007723 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 443150007724 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 443150007725 RNA/DNA hybrid binding site [nucleotide binding]; other site 443150007726 active site 443150007727 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 443150007728 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 443150007729 Catalytic site [active] 443150007730 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 443150007731 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 443150007732 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 443150007733 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 443150007734 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 443150007735 RimM N-terminal domain; Region: RimM; pfam01782 443150007736 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 443150007737 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 443150007738 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 443150007739 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 443150007740 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443150007741 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443150007742 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 443150007743 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 443150007744 active site 443150007745 putative substrate binding pocket [chemical binding]; other site 443150007746 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 443150007747 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 443150007748 Catalytic domain of Protein Kinases; Region: PKc; cd00180 443150007749 active site 443150007750 ATP binding site [chemical binding]; other site 443150007751 substrate binding site [chemical binding]; other site 443150007752 activation loop (A-loop); other site 443150007753 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 443150007754 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 443150007755 active site 443150007756 signal recognition particle protein; Provisional; Region: PRK10867 443150007757 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 443150007758 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 443150007759 P loop; other site 443150007760 GTP binding site [chemical binding]; other site 443150007761 Signal peptide binding domain; Region: SRP_SPB; pfam02978 443150007762 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 443150007763 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 443150007764 ATP binding site [chemical binding]; other site 443150007765 putative Mg++ binding site [ion binding]; other site 443150007766 PII uridylyl-transferase; Provisional; Region: PRK03381 443150007767 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 443150007768 metal binding triad; other site 443150007769 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 443150007770 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443150007771 Zn2+ binding site [ion binding]; other site 443150007772 Mg2+ binding site [ion binding]; other site 443150007773 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 443150007774 Nitrogen regulatory protein P-II; Region: P-II; smart00938 443150007775 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 443150007776 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 443150007777 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 443150007778 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 443150007779 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 443150007780 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 443150007781 Walker A/P-loop; other site 443150007782 ATP binding site [chemical binding]; other site 443150007783 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 443150007784 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 443150007785 ABC transporter signature motif; other site 443150007786 Walker B; other site 443150007787 D-loop; other site 443150007788 H-loop/switch region; other site 443150007789 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 443150007790 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 443150007791 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 443150007792 DNA binding site [nucleotide binding] 443150007793 catalytic residue [active] 443150007794 H2TH interface [polypeptide binding]; other site 443150007795 putative catalytic residues [active] 443150007796 turnover-facilitating residue; other site 443150007797 intercalation triad [nucleotide binding]; other site 443150007798 8OG recognition residue [nucleotide binding]; other site 443150007799 putative reading head residues; other site 443150007800 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 443150007801 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 443150007802 ribonuclease III; Reviewed; Region: rnc; PRK00102 443150007803 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 443150007804 dimerization interface [polypeptide binding]; other site 443150007805 active site 443150007806 metal binding site [ion binding]; metal-binding site 443150007807 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 443150007808 dsRNA binding site [nucleotide binding]; other site 443150007809 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 443150007810 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 443150007811 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 443150007812 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 443150007813 acyl-CoA synthetase; Validated; Region: PRK05850 443150007814 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 443150007815 acyl-activating enzyme (AAE) consensus motif; other site 443150007816 active site 443150007817 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 443150007818 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 443150007819 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 443150007820 active site 443150007821 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 443150007822 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 443150007823 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 443150007824 NADP binding site [chemical binding]; other site 443150007825 KR domain; Region: KR; pfam08659 443150007826 active site 443150007827 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 443150007828 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 443150007829 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 443150007830 active site 443150007831 Acyl transferase domain; Region: Acyl_transf_1; cl08282 443150007832 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 443150007833 KR domain; Region: KR; pfam08659 443150007834 NADP binding site [chemical binding]; other site 443150007835 active site 443150007836 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 443150007837 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 443150007838 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 443150007839 active site 443150007840 Acyl transferase domain; Region: Acyl_transf_1; cl08282 443150007841 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 443150007842 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443150007843 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 443150007844 Enoylreductase; Region: PKS_ER; smart00829 443150007845 NAD(P) binding site [chemical binding]; other site 443150007846 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 443150007847 KR domain; Region: KR; pfam08659 443150007848 putative NADP binding site [chemical binding]; other site 443150007849 active site 443150007850 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 443150007851 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 443150007852 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 443150007853 active site 443150007854 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 443150007855 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 443150007856 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 443150007857 KR domain; Region: KR; pfam08659 443150007858 putative NADP binding site [chemical binding]; other site 443150007859 active site 443150007860 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 443150007861 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 443150007862 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 443150007863 active site 443150007864 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 443150007865 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 443150007866 Condensation domain; Region: Condensation; pfam00668 443150007867 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 443150007868 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443150007869 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 443150007870 Walker A/P-loop; other site 443150007871 ATP binding site [chemical binding]; other site 443150007872 Q-loop/lid; other site 443150007873 ABC transporter signature motif; other site 443150007874 Walker B; other site 443150007875 D-loop; other site 443150007876 H-loop/switch region; other site 443150007877 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 443150007878 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 443150007879 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 443150007880 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 443150007881 acyltransferase PapA5; Provisional; Region: PRK09294 443150007882 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 443150007883 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 443150007884 active site 443150007885 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 443150007886 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 443150007887 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443150007888 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 443150007889 Enoylreductase; Region: PKS_ER; smart00829 443150007890 NAD(P) binding site [chemical binding]; other site 443150007891 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 443150007892 KR domain; Region: KR; pfam08659 443150007893 putative NADP binding site [chemical binding]; other site 443150007894 active site 443150007895 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 443150007896 acyl-CoA synthetase; Validated; Region: PRK05850 443150007897 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 443150007898 acyl-activating enzyme (AAE) consensus motif; other site 443150007899 active site 443150007900 MMPL family; Region: MMPL; pfam03176 443150007901 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 443150007902 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 443150007903 Integrase core domain; Region: rve; pfam00665 443150007904 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 443150007905 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 443150007906 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 443150007907 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 443150007908 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 443150007909 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443150007910 Enoylreductase; Region: PKS_ER; smart00829 443150007911 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 443150007912 NAD(P) binding site [chemical binding]; other site 443150007913 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 443150007914 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 443150007915 putative NADP binding site [chemical binding]; other site 443150007916 active site 443150007917 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 443150007918 Erythronolide synthase docking; Region: Docking; pfam08990 443150007919 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 443150007920 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 443150007921 active site 443150007922 acyl-CoA synthetase; Validated; Region: PRK06060 443150007923 Benzoate CoA ligase (BCL) and similar adenylate forming enzymes; Region: BCL_like; cd05919 443150007924 dimer interface [polypeptide binding]; other site 443150007925 acyl-activating enzyme (AAE) consensus motif; other site 443150007926 putative active site [active] 443150007927 putative AMP binding site [chemical binding]; other site 443150007928 putative CoA binding site [chemical binding]; other site 443150007929 chemical substrate binding site [chemical binding]; other site 443150007930 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 443150007931 acyl-CoA synthetase; Validated; Region: PRK05850 443150007932 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 443150007933 acyl-activating enzyme (AAE) consensus motif; other site 443150007934 active site 443150007935 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 443150007936 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 443150007937 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443150007938 S-adenosylmethionine binding site [chemical binding]; other site 443150007939 Uncharacterized conserved protein [Function unknown]; Region: COG3268 443150007940 Methyltransferase domain; Region: Methyltransf_23; pfam13489 443150007941 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443150007942 S-adenosylmethionine binding site [chemical binding]; other site 443150007943 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 443150007944 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 443150007945 metal-binding site 443150007946 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 443150007947 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 443150007948 active site 443150007949 TDP-binding site; other site 443150007950 acceptor substrate-binding pocket; other site 443150007951 Cephalosporin hydroxylase [Defense mechanisms]; Region: CmcI; COG3510 443150007952 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 443150007953 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 443150007954 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 443150007955 active site 443150007956 TDP-binding site; other site 443150007957 Predicted permease; Region: DUF318; pfam03773 443150007958 formyltetrahydrofolate deformylase; Region: PurU; TIGR00655 443150007959 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 443150007960 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 443150007961 putative active site [active] 443150007962 putative substrate binding site [chemical binding]; other site 443150007963 putative cosubstrate binding site; other site 443150007964 catalytic site [active] 443150007965 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 443150007966 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 443150007967 active site 443150007968 (T/H)XGH motif; other site 443150007969 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 443150007970 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443150007971 S-adenosylmethionine binding site [chemical binding]; other site 443150007972 pyruvate carboxylase; Reviewed; Region: PRK12999 443150007973 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 443150007974 ATP-grasp domain; Region: ATP-grasp_4; cl17255 443150007975 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 443150007976 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 443150007977 active site 443150007978 catalytic residues [active] 443150007979 metal binding site [ion binding]; metal-binding site 443150007980 homodimer binding site [polypeptide binding]; other site 443150007981 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 443150007982 carboxyltransferase (CT) interaction site; other site 443150007983 biotinylation site [posttranslational modification]; other site 443150007984 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 443150007985 putative active site [active] 443150007986 redox center [active] 443150007987 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 443150007988 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 443150007989 catalytic residues [active] 443150007990 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 443150007991 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 443150007992 substrate binding pocket [chemical binding]; other site 443150007993 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 443150007994 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 443150007995 active site 443150007996 catalytic tetrad [active] 443150007997 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 443150007998 RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200 443150007999 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 443150008000 generic binding surface II; other site 443150008001 ssDNA binding site; other site 443150008002 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443150008003 ATP binding site [chemical binding]; other site 443150008004 putative Mg++ binding site [ion binding]; other site 443150008005 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443150008006 nucleotide binding region [chemical binding]; other site 443150008007 ATP-binding site [chemical binding]; other site 443150008008 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 443150008009 DAK2 domain; Region: Dak2; cl03685 443150008010 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 443150008011 ligand binding site [chemical binding]; other site 443150008012 active site 443150008013 UGI interface [polypeptide binding]; other site 443150008014 catalytic site [active] 443150008015 thiamine monophosphate kinase; Provisional; Region: PRK05731 443150008016 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 443150008017 ATP binding site [chemical binding]; other site 443150008018 dimerization interface [polypeptide binding]; other site 443150008019 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 443150008020 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 443150008021 Probable transposase; Region: OrfB_IS605; pfam01385 443150008022 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 443150008023 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 443150008024 catalytic residues [active] 443150008025 catalytic nucleophile [active] 443150008026 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 443150008027 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 443150008028 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 443150008029 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 443150008030 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 443150008031 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 443150008032 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 443150008033 Predicted nucleotidyltransferase, CobY/MobA/RfbA family [General function prediction only]; Region: COG1920 443150008034 polyphosphate kinase; Provisional; Region: PRK05443 443150008035 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 443150008036 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 443150008037 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 443150008038 putative domain interface [polypeptide binding]; other site 443150008039 putative active site [active] 443150008040 catalytic site [active] 443150008041 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 443150008042 putative domain interface [polypeptide binding]; other site 443150008043 putative active site [active] 443150008044 catalytic site [active] 443150008045 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 443150008046 active site 443150008047 Ap6A binding site [chemical binding]; other site 443150008048 nudix motif; other site 443150008049 metal binding site [ion binding]; metal-binding site 443150008050 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 443150008051 catalytic core [active] 443150008052 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 443150008053 IHF - DNA interface [nucleotide binding]; other site 443150008054 IHF dimer interface [polypeptide binding]; other site 443150008055 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 443150008056 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 443150008057 substrate binding site [chemical binding]; other site 443150008058 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 443150008059 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 443150008060 substrate binding site [chemical binding]; other site 443150008061 ligand binding site [chemical binding]; other site 443150008062 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 443150008063 Transcriptional regulator [Transcription]; Region: IclR; COG1414 443150008064 Bacterial transcriptional regulator; Region: IclR; pfam01614 443150008065 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443150008066 S-adenosylmethionine binding site [chemical binding]; other site 443150008067 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 443150008068 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 443150008069 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 443150008070 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 443150008071 active site 443150008072 HIGH motif; other site 443150008073 nucleotide binding site [chemical binding]; other site 443150008074 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 443150008075 active site 443150008076 KMSKS motif; other site 443150008077 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 443150008078 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 443150008079 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 443150008080 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 443150008081 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 443150008082 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 443150008083 ligand binding site [chemical binding]; other site 443150008084 NAD binding site [chemical binding]; other site 443150008085 dimerization interface [polypeptide binding]; other site 443150008086 catalytic site [active] 443150008087 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 443150008088 putative L-serine binding site [chemical binding]; other site 443150008089 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 443150008090 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 443150008091 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 443150008092 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 443150008093 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 443150008094 ketol-acid reductoisomerase; Provisional; Region: PRK05479 443150008095 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 443150008096 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 443150008097 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 443150008098 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 443150008099 putative valine binding site [chemical binding]; other site 443150008100 dimer interface [polypeptide binding]; other site 443150008101 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 443150008102 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 443150008103 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 443150008104 PYR/PP interface [polypeptide binding]; other site 443150008105 dimer interface [polypeptide binding]; other site 443150008106 TPP binding site [chemical binding]; other site 443150008107 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 443150008108 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 443150008109 TPP-binding site [chemical binding]; other site 443150008110 dimer interface [polypeptide binding]; other site 443150008111 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 443150008112 Predicted membrane protein [Function unknown]; Region: COG2259 443150008113 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 443150008114 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 443150008115 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 443150008116 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 443150008117 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 443150008118 GatB domain; Region: GatB_Yqey; smart00845 443150008119 6-phosphofructokinase; Provisional; Region: PRK03202 443150008120 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 443150008121 active site 443150008122 ADP/pyrophosphate binding site [chemical binding]; other site 443150008123 dimerization interface [polypeptide binding]; other site 443150008124 allosteric effector site; other site 443150008125 fructose-1,6-bisphosphate binding site; other site 443150008126 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 443150008127 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 443150008128 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 443150008129 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 443150008130 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 443150008131 nucleotide binding pocket [chemical binding]; other site 443150008132 K-X-D-G motif; other site 443150008133 catalytic site [active] 443150008134 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 443150008135 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 443150008136 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 443150008137 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 443150008138 Dimer interface [polypeptide binding]; other site 443150008139 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 443150008140 PknH-like extracellular domain; Region: PknH_C; pfam14032 443150008141 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 443150008142 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150008143 PPE family; Region: PPE; pfam00823 443150008144 putative transposase OrfB; Reviewed; Region: PHA02517 443150008145 HTH-like domain; Region: HTH_21; pfam13276 443150008146 Integrase core domain; Region: rve; pfam00665 443150008147 Integrase core domain; Region: rve_3; pfam13683 443150008148 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 443150008149 Transposase; Region: HTH_Tnp_1; cl17663 443150008150 HTH-like domain; Region: HTH_21; pfam13276 443150008151 Integrase core domain; Region: rve; pfam00665 443150008152 Integrase core domain; Region: rve_3; pfam13683 443150008153 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150008154 PPE family; Region: PPE; pfam00823 443150008155 Transposase, Mutator family; Region: Transposase_mut; pfam00872 443150008156 MULE transposase domain; Region: MULE; pfam10551 443150008157 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 443150008158 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 443150008159 Ligand Binding Site [chemical binding]; other site 443150008160 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 443150008161 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 443150008162 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443150008163 catalytic residue [active] 443150008164 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 443150008165 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 443150008166 putative acyl-acceptor binding pocket; other site 443150008167 Putative hemolysin [General function prediction only]; Region: COG3176 443150008168 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 443150008169 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 443150008170 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 443150008171 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 443150008172 Ligand binding site [chemical binding]; other site 443150008173 Electron transfer flavoprotein domain; Region: ETF; pfam01012 443150008174 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443150008175 S-adenosylmethionine binding site [chemical binding]; other site 443150008176 Uncharacterized conserved protein [Function unknown]; Region: COG1543 443150008177 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 443150008178 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 443150008179 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443150008180 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 443150008181 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 443150008182 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 443150008183 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 443150008184 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 443150008185 trimer interface [polypeptide binding]; other site 443150008186 active site 443150008187 substrate binding site [chemical binding]; other site 443150008188 CoA binding site [chemical binding]; other site 443150008189 FOG: WD40-like repeat [Function unknown]; Region: COG1520 443150008190 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 443150008191 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443150008192 S-adenosylmethionine binding site [chemical binding]; other site 443150008193 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443150008194 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 443150008195 substrate binding site [chemical binding]; other site 443150008196 oxyanion hole (OAH) forming residues; other site 443150008197 trimer interface [polypeptide binding]; other site 443150008198 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 443150008199 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443150008200 Walker A/P-loop; other site 443150008201 ATP binding site [chemical binding]; other site 443150008202 Q-loop/lid; other site 443150008203 ABC transporter signature motif; other site 443150008204 Walker B; other site 443150008205 D-loop; other site 443150008206 H-loop/switch region; other site 443150008207 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 443150008208 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 443150008209 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 443150008210 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443150008211 motif II; other site 443150008212 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 443150008213 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 443150008214 D-pathway; other site 443150008215 Putative ubiquinol binding site [chemical binding]; other site 443150008216 Low-spin heme (heme b) binding site [chemical binding]; other site 443150008217 Putative water exit pathway; other site 443150008218 Binuclear center (heme o3/CuB) [ion binding]; other site 443150008219 K-pathway; other site 443150008220 Putative proton exit pathway; other site 443150008221 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 443150008222 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 443150008223 siderophore binding site; other site 443150008224 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 443150008225 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 443150008226 putative NAD(P) binding site [chemical binding]; other site 443150008227 putative substrate binding site [chemical binding]; other site 443150008228 catalytic Zn binding site [ion binding]; other site 443150008229 structural Zn binding site [ion binding]; other site 443150008230 dimer interface [polypeptide binding]; other site 443150008231 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 443150008232 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 443150008233 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 443150008234 dimer interface [polypeptide binding]; other site 443150008235 putative radical transfer pathway; other site 443150008236 diiron center [ion binding]; other site 443150008237 tyrosyl radical; other site 443150008238 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 443150008239 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 443150008240 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443150008241 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443150008242 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 443150008243 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 443150008244 Class I ribonucleotide reductase; Region: RNR_I; cd01679 443150008245 active site 443150008246 dimer interface [polypeptide binding]; other site 443150008247 catalytic residues [active] 443150008248 effector binding site; other site 443150008249 R2 peptide binding site; other site 443150008250 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 443150008251 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 443150008252 Predicted flavoprotein [General function prediction only]; Region: COG0431 443150008253 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443150008254 DNA polymerase IV; Validated; Region: PRK03352 443150008255 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 443150008256 active site 443150008257 DNA binding site [nucleotide binding] 443150008258 short chain dehydrogenase; Provisional; Region: PRK07832 443150008259 classical (c) SDRs; Region: SDR_c; cd05233 443150008260 NAD(P) binding site [chemical binding]; other site 443150008261 active site 443150008262 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443150008263 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443150008264 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443150008265 Cytochrome P450; Region: p450; cl12078 443150008266 Transcriptional regulators [Transcription]; Region: FadR; COG2186 443150008267 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443150008268 DNA-binding site [nucleotide binding]; DNA binding site 443150008269 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 443150008270 Transcriptional regulators [Transcription]; Region: FadR; COG2186 443150008271 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443150008272 DNA-binding site [nucleotide binding]; DNA binding site 443150008273 FCD domain; Region: FCD; pfam07729 443150008274 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443150008275 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 443150008276 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443150008277 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443150008278 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443150008279 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443150008280 active site 443150008281 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 443150008282 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 443150008283 active site 443150008284 DNA binding site [nucleotide binding] 443150008285 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 443150008286 DNA binding site [nucleotide binding] 443150008287 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 443150008288 Carbon starvation protein CstA; Region: CstA; pfam02554 443150008289 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 443150008290 DoxX; Region: DoxX; pfam07681 443150008291 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 443150008292 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 443150008293 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443150008294 Protein of unknown function (DUF732); Region: DUF732; pfam05305 443150008295 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 443150008296 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 443150008297 active site 443150008298 substrate binding site [chemical binding]; other site 443150008299 metal binding site [ion binding]; metal-binding site 443150008300 camphor resistance protein CrcB; Provisional; Region: PRK14216 443150008301 camphor resistance protein CrcB; Provisional; Region: PRK14228 443150008302 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 443150008303 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 443150008304 Uncharacterized ACR, COG1993; Region: DUF190; pfam02641 443150008305 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 443150008306 Uncharacterized conserved protein [Function unknown]; Region: COG3189 443150008307 Domain of unknown function (DUF222); Region: DUF222; pfam02720 443150008308 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 443150008309 active site 443150008310 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 443150008311 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 443150008312 putative hydrophobic ligand binding site [chemical binding]; other site 443150008313 protein interface [polypeptide binding]; other site 443150008314 gate; other site 443150008315 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 443150008316 Sulfatase; Region: Sulfatase; pfam00884 443150008317 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 443150008318 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 443150008319 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 443150008320 Catalytic domain of Protein Kinases; Region: PKc; cd00180 443150008321 active site 443150008322 ATP binding site [chemical binding]; other site 443150008323 substrate binding site [chemical binding]; other site 443150008324 activation loop (A-loop); other site 443150008325 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 443150008326 AAA ATPase domain; Region: AAA_16; pfam13191 443150008327 Nucleotidyl transferase of unknown function (DUF2204); Region: DUF2204; cl17690 443150008328 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 443150008329 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 443150008330 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 443150008331 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 443150008332 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 443150008333 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 443150008334 short chain dehydrogenase; Provisional; Region: PRK07832 443150008335 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443150008336 NAD(P) binding site [chemical binding]; other site 443150008337 active site 443150008338 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 443150008339 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 443150008340 NAD binding site [chemical binding]; other site 443150008341 catalytic Zn binding site [ion binding]; other site 443150008342 substrate binding site [chemical binding]; other site 443150008343 structural Zn binding site [ion binding]; other site 443150008344 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443150008345 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443150008346 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443150008347 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443150008348 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 443150008349 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 443150008350 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443150008351 acyl-activating enzyme (AAE) consensus motif; other site 443150008352 AMP binding site [chemical binding]; other site 443150008353 active site 443150008354 CoA binding site [chemical binding]; other site 443150008355 SPFH domain / Band 7 family; Region: Band_7; pfam01145 443150008356 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 443150008357 Patatin-like phospholipase; Region: Patatin; pfam01734 443150008358 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 443150008359 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 443150008360 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443150008361 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443150008362 active site 443150008363 Predicted transcriptional regulators [Transcription]; Region: COG1733 443150008364 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443150008365 dimerization interface [polypeptide binding]; other site 443150008366 putative DNA binding site [nucleotide binding]; other site 443150008367 putative Zn2+ binding site [ion binding]; other site 443150008368 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 443150008369 PE family; Region: PE; pfam00934 443150008370 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 443150008371 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 443150008372 PemK-like protein; Region: PemK; pfam02452 443150008373 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 443150008374 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 443150008375 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 443150008376 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 443150008377 SmpB-tmRNA interface; other site 443150008378 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 443150008379 FtsX-like permease family; Region: FtsX; pfam02687 443150008380 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 443150008381 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443150008382 Walker A/P-loop; other site 443150008383 ATP binding site [chemical binding]; other site 443150008384 Q-loop/lid; other site 443150008385 ABC transporter signature motif; other site 443150008386 Walker B; other site 443150008387 D-loop; other site 443150008388 H-loop/switch region; other site 443150008389 Mechanosensitive ion channel; Region: MS_channel; pfam00924 443150008390 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 443150008391 peptide chain release factor 2; Validated; Region: prfB; PRK00578 443150008392 This domain is found in peptide chain release factors; Region: PCRF; smart00937 443150008393 RF-1 domain; Region: RF-1; pfam00472 443150008394 ferredoxin-NADP+ reductase; Region: PLN02852 443150008395 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 443150008396 FAD binding domain; Region: FAD_binding_4; pfam01565 443150008397 Molybdenum cofactor biosynthesis enzyme [Coenzyme metabolism]; Region: MoaA; COG2896 443150008398 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443150008399 FeS/SAM binding site; other site 443150008400 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 443150008401 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 443150008402 trimer interface [polypeptide binding]; other site 443150008403 dimer interface [polypeptide binding]; other site 443150008404 putative active site [active] 443150008405 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 443150008406 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 443150008407 Transposase, Mutator family; Region: Transposase_mut; pfam00872 443150008408 MULE transposase domain; Region: MULE; pfam10551 443150008409 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 443150008410 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 443150008411 ATP binding site [chemical binding]; other site 443150008412 substrate interface [chemical binding]; other site 443150008413 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 443150008414 active site residue [active] 443150008415 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 443150008416 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 443150008417 active site residue [active] 443150008418 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 443150008419 active site residue [active] 443150008420 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 443150008421 MoaE homodimer interface [polypeptide binding]; other site 443150008422 MoaD interaction [polypeptide binding]; other site 443150008423 active site residues [active] 443150008424 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443150008425 S-adenosylmethionine binding site [chemical binding]; other site 443150008426 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443150008427 Cytochrome P450; Region: p450; cl12078 443150008428 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 443150008429 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 443150008430 DNA binding site [nucleotide binding] 443150008431 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150008432 PPE family; Region: PPE; pfam00823 443150008433 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 443150008434 putative transposase OrfB; Reviewed; Region: PHA02517 443150008435 HTH-like domain; Region: HTH_21; pfam13276 443150008436 Integrase core domain; Region: rve; pfam00665 443150008437 Integrase core domain; Region: rve_3; pfam13683 443150008438 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 443150008439 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443150008440 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443150008441 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 443150008442 dimer interface [polypeptide binding]; other site 443150008443 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 443150008444 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 443150008445 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 443150008446 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 443150008447 Histidine kinase; Region: HisKA_3; pfam07730 443150008448 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443150008449 ATP binding site [chemical binding]; other site 443150008450 Mg2+ binding site [ion binding]; other site 443150008451 G-X-G motif; other site 443150008452 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443150008453 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443150008454 active site 443150008455 phosphorylation site [posttranslational modification] 443150008456 intermolecular recognition site; other site 443150008457 dimerization interface [polypeptide binding]; other site 443150008458 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443150008459 DNA binding residues [nucleotide binding] 443150008460 dimerization interface [polypeptide binding]; other site 443150008461 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 443150008462 Ligand Binding Site [chemical binding]; other site 443150008463 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150008464 PPE family; Region: PPE; pfam00823 443150008465 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150008466 PPE family; Region: PPE; pfam00823 443150008467 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 443150008468 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 443150008469 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 443150008470 active site 443150008471 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 443150008472 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443150008473 FeS/SAM binding site; other site 443150008474 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443150008475 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443150008476 active site 443150008477 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443150008478 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443150008479 active site 443150008480 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 443150008481 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 443150008482 NAD(P) binding site [chemical binding]; other site 443150008483 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443150008484 active site 443150008485 phosphorylation site [posttranslational modification] 443150008486 intermolecular recognition site; other site 443150008487 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150008488 PPE family; Region: PPE; pfam00823 443150008489 NADH dehydrogenase subunit A; Validated; Region: PRK07928 443150008490 NADH dehydrogenase subunit B; Validated; Region: PRK06411 443150008491 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 443150008492 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 443150008493 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 443150008494 NADH dehydrogenase subunit D; Validated; Region: PRK06075 443150008495 NADH dehydrogenase subunit E; Validated; Region: PRK07539 443150008496 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 443150008497 putative dimer interface [polypeptide binding]; other site 443150008498 [2Fe-2S] cluster binding site [ion binding]; other site 443150008499 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 443150008500 SLBB domain; Region: SLBB; pfam10531 443150008501 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 443150008502 NADH dehydrogenase subunit G; Validated; Region: PRK07860 443150008503 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443150008504 catalytic loop [active] 443150008505 iron binding site [ion binding]; other site 443150008506 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 443150008507 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 443150008508 [4Fe-4S] binding site [ion binding]; other site 443150008509 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 443150008510 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 443150008511 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 443150008512 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 443150008513 4Fe-4S binding domain; Region: Fer4; pfam00037 443150008514 4Fe-4S binding domain; Region: Fer4; pfam00037 443150008515 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 443150008516 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 443150008517 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 443150008518 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 443150008519 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 443150008520 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 443150008521 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 443150008522 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 443150008523 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150008524 PPE family; Region: PPE; pfam00823 443150008525 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150008526 PPE family; Region: PPE; pfam00823 443150008527 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 443150008528 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443150008529 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 443150008530 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 443150008531 [2Fe-2S] cluster binding site [ion binding]; other site 443150008532 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_1; cd08885 443150008533 putative alpha subunit interface [polypeptide binding]; other site 443150008534 putative active site [active] 443150008535 putative substrate binding site [chemical binding]; other site 443150008536 Fe binding site [ion binding]; other site 443150008537 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 443150008538 Protein of unknown function DUF58; Region: DUF58; pfam01882 443150008539 MoxR-like ATPases [General function prediction only]; Region: COG0714 443150008540 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443150008541 Walker A motif; other site 443150008542 ATP binding site [chemical binding]; other site 443150008543 Walker B motif; other site 443150008544 arginine finger; other site 443150008545 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 443150008546 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443150008547 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443150008548 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 443150008549 putative active site [active] 443150008550 putative substrate binding site [chemical binding]; other site 443150008551 ATP binding site [chemical binding]; other site 443150008552 Phosphotransferase enzyme family; Region: APH; pfam01636 443150008553 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 443150008554 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 443150008555 hydroxyglutarate oxidase; Provisional; Region: PRK11728 443150008556 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443150008557 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 443150008558 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443150008559 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443150008560 short chain dehydrogenase; Validated; Region: PRK08264 443150008561 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443150008562 NAD(P) binding site [chemical binding]; other site 443150008563 active site 443150008564 amidase; Provisional; Region: PRK06170 443150008565 Amidase; Region: Amidase; pfam01425 443150008566 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443150008567 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443150008568 TAP-like protein; Region: Abhydrolase_4; pfam08386 443150008569 Domain of unknown function (DUF385); Region: DUF385; pfam04075 443150008570 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 443150008571 Transposase; Region: HTH_Tnp_1; cl17663 443150008572 putative transposase OrfB; Reviewed; Region: PHA02517 443150008573 HTH-like domain; Region: HTH_21; pfam13276 443150008574 Integrase core domain; Region: rve; pfam00665 443150008575 Integrase core domain; Region: rve_3; pfam13683 443150008576 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 443150008577 AAA domain; Region: AAA_14; pfam13173 443150008578 putative transposase OrfB; Reviewed; Region: PHA02517 443150008579 HTH-like domain; Region: HTH_21; pfam13276 443150008580 Integrase core domain; Region: rve; pfam00665 443150008581 Integrase core domain; Region: rve_3; pfam13683 443150008582 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 443150008583 Transposase; Region: HTH_Tnp_1; cl17663 443150008584 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 443150008585 putative active site [active] 443150008586 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4683 443150008587 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443150008588 non-specific DNA binding site [nucleotide binding]; other site 443150008589 salt bridge; other site 443150008590 sequence-specific DNA binding site [nucleotide binding]; other site 443150008591 Winged helix-turn helix; Region: HTH_29; pfam13551 443150008592 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 443150008593 Helix-turn-helix domain; Region: HTH_38; pfam13936 443150008594 Integrase core domain; Region: rve; pfam00665 443150008595 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 443150008596 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 443150008597 Uncharacterized conserved protein [Function unknown]; Region: COG1615 443150008598 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 443150008599 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 443150008600 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 443150008601 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 443150008602 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 443150008603 Uncharacterized conserved protein [Function unknown]; Region: COG5282 443150008604 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 443150008605 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 443150008606 ABC1 family; Region: ABC1; pfam03109 443150008607 Phosphotransferase enzyme family; Region: APH; pfam01636 443150008608 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 443150008609 active site 443150008610 ATP binding site [chemical binding]; other site 443150008611 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 443150008612 Part of AAA domain; Region: AAA_19; pfam13245 443150008613 Family description; Region: UvrD_C_2; pfam13538 443150008614 HRDC domain; Region: HRDC; pfam00570 443150008615 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 443150008616 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 443150008617 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 443150008618 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 443150008619 putative NADH binding site [chemical binding]; other site 443150008620 putative active site [active] 443150008621 nudix motif; other site 443150008622 putative metal binding site [ion binding]; other site 443150008623 Ion channel; Region: Ion_trans_2; pfam07885 443150008624 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 443150008625 TrkA-N domain; Region: TrkA_N; pfam02254 443150008626 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 443150008627 Part of AAA domain; Region: AAA_19; pfam13245 443150008628 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 443150008629 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 443150008630 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 443150008631 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 443150008632 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443150008633 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 443150008634 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 443150008635 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 443150008636 active site 443150008637 DNA binding site [nucleotide binding] 443150008638 TIGR02569 family protein; Region: TIGR02569_actnb 443150008639 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 443150008640 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 443150008641 ATP binding site [chemical binding]; other site 443150008642 substrate interface [chemical binding]; other site 443150008643 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 443150008644 active site residue [active] 443150008645 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 443150008646 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443150008647 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443150008648 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like; Region: MiaE_2; pfam13794 443150008649 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 443150008650 DEAD-like helicases superfamily; Region: DEXDc; smart00487 443150008651 ATP binding site [chemical binding]; other site 443150008652 Mg++ binding site [ion binding]; other site 443150008653 motif III; other site 443150008654 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443150008655 nucleotide binding region [chemical binding]; other site 443150008656 ATP-binding site [chemical binding]; other site 443150008657 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 443150008658 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 443150008659 P-loop; other site 443150008660 Magnesium ion binding site [ion binding]; other site 443150008661 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 443150008662 Magnesium ion binding site [ion binding]; other site 443150008663 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 443150008664 catalytic core [active] 443150008665 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 443150008666 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 443150008667 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 443150008668 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 443150008669 PAS domain S-box; Region: sensory_box; TIGR00229 443150008670 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 443150008671 Histidine kinase; Region: HisKA_2; pfam07568 443150008672 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443150008673 ATP binding site [chemical binding]; other site 443150008674 Mg2+ binding site [ion binding]; other site 443150008675 G-X-G motif; other site 443150008676 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 443150008677 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 443150008678 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443150008679 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443150008680 DNA binding residues [nucleotide binding] 443150008681 short chain dehydrogenase; Provisional; Region: PRK08278 443150008682 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 443150008683 NAD(P) binding site [chemical binding]; other site 443150008684 homodimer interface [polypeptide binding]; other site 443150008685 active site 443150008686 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 443150008687 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443150008688 Coenzyme A binding pocket [chemical binding]; other site 443150008689 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 443150008690 Phosphotransferase enzyme family; Region: APH; pfam01636 443150008691 putative active site [active] 443150008692 putative substrate binding site [chemical binding]; other site 443150008693 ATP binding site [chemical binding]; other site 443150008694 Uncharacterized conserved protein [Function unknown]; Region: COG2135 443150008695 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 443150008696 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 443150008697 hinge; other site 443150008698 active site 443150008699 Predicted GTPases [General function prediction only]; Region: COG1162 443150008700 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 443150008701 GTPase/Zn-binding domain interface [polypeptide binding]; other site 443150008702 GTP/Mg2+ binding site [chemical binding]; other site 443150008703 G4 box; other site 443150008704 G5 box; other site 443150008705 G1 box; other site 443150008706 Switch I region; other site 443150008707 G2 box; other site 443150008708 G3 box; other site 443150008709 Switch II region; other site 443150008710 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 443150008711 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 443150008712 putative di-iron ligands [ion binding]; other site 443150008713 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 443150008714 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 443150008715 FAD binding pocket [chemical binding]; other site 443150008716 FAD binding motif [chemical binding]; other site 443150008717 phosphate binding motif [ion binding]; other site 443150008718 beta-alpha-beta structure motif; other site 443150008719 NAD binding pocket [chemical binding]; other site 443150008720 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443150008721 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 443150008722 catalytic loop [active] 443150008723 iron binding site [ion binding]; other site 443150008724 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 443150008725 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443150008726 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443150008727 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 443150008728 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 443150008729 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 443150008730 TrkA-C domain; Region: TrkA_C; pfam02080 443150008731 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 443150008732 potential frameshift: common BLAST hit: gi|378772987|ref|YP_005172720.1| putative transmembrane transport protein 443150008733 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 443150008734 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 443150008735 ligand binding site [chemical binding]; other site 443150008736 flexible hinge region; other site 443150008737 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 443150008738 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 443150008739 nucleophile elbow; other site 443150008740 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443150008741 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 443150008742 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 443150008743 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 443150008744 30S subunit binding site; other site 443150008745 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 443150008746 active site 443150008747 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 443150008748 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 443150008749 lipoprotein LpqB; Provisional; Region: PRK13616 443150008750 Sporulation and spore germination; Region: Germane; pfam10646 443150008751 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 443150008752 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443150008753 dimerization interface [polypeptide binding]; other site 443150008754 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443150008755 dimer interface [polypeptide binding]; other site 443150008756 phosphorylation site [posttranslational modification] 443150008757 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443150008758 ATP binding site [chemical binding]; other site 443150008759 Mg2+ binding site [ion binding]; other site 443150008760 G-X-G motif; other site 443150008761 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 443150008762 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443150008763 active site 443150008764 phosphorylation site [posttranslational modification] 443150008765 intermolecular recognition site; other site 443150008766 dimerization interface [polypeptide binding]; other site 443150008767 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443150008768 DNA binding site [nucleotide binding] 443150008769 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 443150008770 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 443150008771 TMP-binding site; other site 443150008772 ATP-binding site [chemical binding]; other site 443150008773 Adenosylhomocysteinase; Provisional; Region: PTZ00075 443150008774 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 443150008775 homotetramer interface [polypeptide binding]; other site 443150008776 ligand binding site [chemical binding]; other site 443150008777 catalytic site [active] 443150008778 NAD binding site [chemical binding]; other site 443150008779 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443150008780 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 443150008781 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 443150008782 Fatty acid desaturase; Region: FA_desaturase; pfam00487 443150008783 Di-iron ligands [ion binding]; other site 443150008784 amino acid transporter; Region: 2A0306; TIGR00909 443150008785 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 443150008786 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 443150008787 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 443150008788 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 443150008789 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 443150008790 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 443150008791 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 443150008792 active site 443150008793 substrate binding site [chemical binding]; other site 443150008794 metal binding site [ion binding]; metal-binding site 443150008795 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 443150008796 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 443150008797 Transcription factor WhiB; Region: Whib; pfam02467 443150008798 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 443150008799 LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186 443150008800 phosphate binding site [ion binding]; other site 443150008801 dimer interface [polypeptide binding]; other site 443150008802 substrate binding site [chemical binding]; other site 443150008803 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 443150008804 F420-0:gamma-glutamyl ligase; Region: F420_cofE; TIGR01916 443150008805 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 443150008806 putative FMN binding site [chemical binding]; other site 443150008807 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 443150008808 Methyltransferase domain; Region: Methyltransf_26; pfam13659 443150008809 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 443150008810 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 443150008811 active site 443150008812 Substrate binding site; other site 443150008813 Mg++ binding site; other site 443150008814 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 443150008815 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 443150008816 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 443150008817 Probable Catalytic site; other site 443150008818 metal-binding site 443150008819 dTDP-4-dehydrorhamnose reductase; Region: rmlD; TIGR01214 443150008820 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 443150008821 NADP binding site [chemical binding]; other site 443150008822 active site 443150008823 putative substrate binding site [chemical binding]; other site 443150008824 Transcriptional regulator [Transcription]; Region: LytR; COG1316 443150008825 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 443150008826 TIGR03089 family protein; Region: TIGR03089 443150008827 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 443150008828 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 443150008829 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 443150008830 active site 443150008831 motif I; other site 443150008832 motif II; other site 443150008833 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 443150008834 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 443150008835 CoA-transferase family III; Region: CoA_transf_3; pfam02515 443150008836 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 443150008837 Sulfate transporter family; Region: Sulfate_transp; pfam00916 443150008838 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: CynT; COG0288 443150008839 active site clefts [active] 443150008840 zinc binding site [ion binding]; other site 443150008841 dimer interface [polypeptide binding]; other site 443150008842 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443150008843 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 443150008844 FAD binding site [chemical binding]; other site 443150008845 homotetramer interface [polypeptide binding]; other site 443150008846 substrate binding pocket [chemical binding]; other site 443150008847 catalytic base [active] 443150008848 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 443150008849 Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) [Nucleotide transport and metabolism]; Region: PurK; COG0026 443150008850 ATP-grasp domain; Region: ATP-grasp; pfam02222 443150008851 Predicted membrane protein [Function unknown]; Region: COG2246 443150008852 GtrA-like protein; Region: GtrA; pfam04138 443150008853 Bacterial PH domain; Region: DUF304; pfam03703 443150008854 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 443150008855 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 443150008856 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 443150008857 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 443150008858 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 443150008859 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 443150008860 Maf-like protein; Region: Maf; pfam02545 443150008861 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 443150008862 active site 443150008863 dimer interface [polypeptide binding]; other site 443150008864 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 443150008865 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 443150008866 active site residue [active] 443150008867 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 443150008868 active site residue [active] 443150008869 Fe-S metabolism associated domain; Region: SufE; pfam02657 443150008870 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 443150008871 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 443150008872 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 443150008873 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 443150008874 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 443150008875 carboxyltransferase (CT) interaction site; other site 443150008876 biotinylation site [posttranslational modification]; other site 443150008877 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 443150008878 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443150008879 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 443150008880 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 443150008881 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 443150008882 L-lysine aminotransferase; Provisional; Region: PRK08297 443150008883 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 443150008884 inhibitor-cofactor binding pocket; inhibition site 443150008885 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443150008886 catalytic residue [active] 443150008887 putative DNA binding site [nucleotide binding]; other site 443150008888 dimerization interface [polypeptide binding]; other site 443150008889 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 443150008890 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 443150008891 putative Zn2+ binding site [ion binding]; other site 443150008892 AsnC family; Region: AsnC_trans_reg; pfam01037 443150008893 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 443150008894 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 443150008895 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 443150008896 tetrameric interface [polypeptide binding]; other site 443150008897 NAD binding site [chemical binding]; other site 443150008898 catalytic residues [active] 443150008899 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 443150008900 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443150008901 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443150008902 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443150008903 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 443150008904 ATP binding site [chemical binding]; other site 443150008905 putative Mg++ binding site [ion binding]; other site 443150008906 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443150008907 nucleotide binding region [chemical binding]; other site 443150008908 ATP-binding site [chemical binding]; other site 443150008909 DEAD/H associated; Region: DEAD_assoc; pfam08494 443150008910 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 443150008911 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 443150008912 putative DNA binding site [nucleotide binding]; other site 443150008913 catalytic residue [active] 443150008914 putative H2TH interface [polypeptide binding]; other site 443150008915 putative catalytic residues [active] 443150008916 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 443150008917 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 443150008918 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 443150008919 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 443150008920 Sulfatase; Region: Sulfatase; pfam00884 443150008921 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 443150008922 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 443150008923 probable active site [active] 443150008924 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 443150008925 PhoU domain; Region: PhoU; pfam01895 443150008926 PhoU domain; Region: PhoU; pfam01895 443150008927 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 443150008928 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 443150008929 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443150008930 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 443150008931 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 443150008932 putative active site pocket [active] 443150008933 dimerization interface [polypeptide binding]; other site 443150008934 putative catalytic residue [active] 443150008935 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 443150008936 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 443150008937 metal binding site [ion binding]; metal-binding site 443150008938 putative dimer interface [polypeptide binding]; other site 443150008939 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 443150008940 amidohydrolase; Region: amidohydrolases; TIGR01891 443150008941 metal binding site [ion binding]; metal-binding site 443150008942 purine nucleoside phosphorylase; Provisional; Region: PRK08202 443150008943 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 443150008944 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 443150008945 active site 443150008946 substrate binding site [chemical binding]; other site 443150008947 metal binding site [ion binding]; metal-binding site 443150008948 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 443150008949 active site 443150008950 Phosphoesterase family; Region: Phosphoesterase; pfam04185 443150008951 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443150008952 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 443150008953 adenosine deaminase; Provisional; Region: PRK09358 443150008954 active site 443150008955 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 443150008956 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 443150008957 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 443150008958 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 443150008959 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 443150008960 active site 443150008961 catalytic motif [active] 443150008962 Zn binding site [ion binding]; other site 443150008963 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 443150008964 putative Iron-sulfur protein interface [polypeptide binding]; other site 443150008965 putative proximal heme binding site [chemical binding]; other site 443150008966 putative SdhD-like interface [polypeptide binding]; other site 443150008967 putative distal heme binding site [chemical binding]; other site 443150008968 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 443150008969 putative Iron-sulfur protein interface [polypeptide binding]; other site 443150008970 putative proximal heme binding site [chemical binding]; other site 443150008971 putative SdhC-like subunit interface [polypeptide binding]; other site 443150008972 putative distal heme binding site [chemical binding]; other site 443150008973 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 443150008974 L-aspartate oxidase; Provisional; Region: PRK06175 443150008975 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 443150008976 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 443150008977 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 443150008978 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 443150008979 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443150008980 S-adenosylmethionine binding site [chemical binding]; other site 443150008981 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 443150008982 MoaE interaction surface [polypeptide binding]; other site 443150008983 MoeB interaction surface [polypeptide binding]; other site 443150008984 thiocarboxylated glycine; other site 443150008985 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 443150008986 MoaE homodimer interface [polypeptide binding]; other site 443150008987 MoaD interaction [polypeptide binding]; other site 443150008988 active site residues [active] 443150008989 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 443150008990 trimer interface [polypeptide binding]; other site 443150008991 dimer interface [polypeptide binding]; other site 443150008992 putative active site [active] 443150008993 Molybdenum cofactor biosynthesis enzyme [Coenzyme metabolism]; Region: MoaA; COG2896 443150008994 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443150008995 FeS/SAM binding site; other site 443150008996 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 443150008997 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 443150008998 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 443150008999 DNA binding site [nucleotide binding] 443150009000 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 443150009001 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 443150009002 phosphopeptide binding site; other site 443150009003 putative transposase OrfB; Reviewed; Region: PHA02517 443150009004 HTH-like domain; Region: HTH_21; pfam13276 443150009005 Integrase core domain; Region: rve; pfam00665 443150009006 Integrase core domain; Region: rve_3; pfam13683 443150009007 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 443150009008 Transposase; Region: DEDD_Tnp_IS110; pfam01548 443150009009 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 443150009010 Uncharacterized conserved protein [Function unknown]; Region: COG2128 443150009011 hypothetical protein; Provisional; Region: PRK06541 443150009012 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 443150009013 inhibitor-cofactor binding pocket; inhibition site 443150009014 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443150009015 catalytic residue [active] 443150009016 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 443150009017 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 443150009018 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 443150009019 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443150009020 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 443150009021 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 443150009022 active site 443150009023 dimer interface [polypeptide binding]; other site 443150009024 Protein of unknown function (DUF732); Region: DUF732; pfam05305 443150009025 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 443150009026 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 443150009027 DNA binding residues [nucleotide binding] 443150009028 dimer interface [polypeptide binding]; other site 443150009029 metal binding site [ion binding]; metal-binding site 443150009030 inner membrane protein YhjD; Region: TIGR00766 443150009031 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 443150009032 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 443150009033 active site 443150009034 dimer interface [polypeptide binding]; other site 443150009035 KMSKS motif; other site 443150009036 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 443150009037 isocitrate dehydrogenase; Validated; Region: PRK08299 443150009038 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 443150009039 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 443150009040 homodimer interface [polypeptide binding]; other site 443150009041 substrate-cofactor binding pocket; other site 443150009042 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443150009043 catalytic residue [active] 443150009044 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 443150009045 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 443150009046 Methyltransferase domain; Region: Methyltransf_23; pfam13489 443150009047 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443150009048 S-adenosylmethionine binding site [chemical binding]; other site 443150009049 PPE family; Region: PPE; pfam00823 443150009050 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150009051 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150009052 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443150009053 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443150009054 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443150009055 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150009056 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443150009057 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443150009058 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150009059 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443150009060 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443150009061 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443150009062 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150009063 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443150009064 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443150009065 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443150009066 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150009067 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443150009068 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443150009069 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443150009070 PE family; Region: PE; pfam00934 443150009071 PPE family; Region: PPE; pfam00823 443150009072 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443150009073 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443150009074 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150009075 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443150009076 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443150009077 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150009078 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443150009079 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443150009080 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150009081 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443150009082 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443150009083 Transposase; Region: DEDD_Tnp_IS110; pfam01548 443150009084 Transposase; Region: DDE_Tnp_ISL3; pfam01610 443150009085 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150009086 PPE family; Region: PPE; pfam00823 443150009087 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150009088 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443150009089 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443150009090 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150009091 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443150009092 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443150009093 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443150009094 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443150009095 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150009096 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443150009097 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443150009098 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150009099 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443150009100 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443150009101 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443150009102 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443150009103 Berberine and berberine like; Region: BBE; pfam08031 443150009104 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 443150009105 Protein of unknown function (DUF732); Region: DUF732; pfam05305 443150009106 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 443150009107 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 443150009108 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 443150009109 homodimer interface [polypeptide binding]; other site 443150009110 NADP binding site [chemical binding]; other site 443150009111 substrate binding site [chemical binding]; other site 443150009112 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 443150009113 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 443150009114 active site 443150009115 FMN binding site [chemical binding]; other site 443150009116 substrate binding site [chemical binding]; other site 443150009117 putative catalytic residue [active] 443150009118 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 443150009119 phosphate binding site [ion binding]; other site 443150009120 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 443150009121 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 443150009122 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 443150009123 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 443150009124 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 443150009125 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 443150009126 G1 box; other site 443150009127 GTP/Mg2+ binding site [chemical binding]; other site 443150009128 G2 box; other site 443150009129 Switch I region; other site 443150009130 G3 box; other site 443150009131 Switch II region; other site 443150009132 G4 box; other site 443150009133 G5 box; other site 443150009134 Protein of unknown function (DUF742); Region: DUF742; pfam05331 443150009135 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 443150009136 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443150009137 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443150009138 ATP binding site [chemical binding]; other site 443150009139 Mg2+ binding site [ion binding]; other site 443150009140 G-X-G motif; other site 443150009141 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 443150009142 PE family; Region: PE; pfam00934 443150009143 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 443150009144 FMN binding site [chemical binding]; other site 443150009145 dimer interface [polypeptide binding]; other site 443150009146 PPOX class probable F420-dependent enzyme, Rv3369 family; Region: Rv3369; TIGR03667 443150009147 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 443150009148 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 443150009149 active site 443150009150 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 443150009151 generic binding surface II; other site 443150009152 generic binding surface I; other site 443150009153 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443150009154 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443150009155 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 443150009156 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 443150009157 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443150009158 active site 443150009159 motif I; other site 443150009160 motif II; other site 443150009161 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443150009162 substrate binding site [chemical binding]; other site 443150009163 oxyanion hole (OAH) forming residues; other site 443150009164 trimer interface [polypeptide binding]; other site 443150009165 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 443150009166 Amidase; Region: Amidase; pfam01425 443150009167 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 443150009168 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443150009169 motif II; other site 443150009170 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 443150009171 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 443150009172 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12571 443150009173 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 443150009174 TPP-binding site; other site 443150009175 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 443150009176 PYR/PP interface [polypeptide binding]; other site 443150009177 dimer interface [polypeptide binding]; other site 443150009178 TPP binding site [chemical binding]; other site 443150009179 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 443150009180 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 443150009181 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 443150009182 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 443150009183 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 443150009184 substrate binding pocket [chemical binding]; other site 443150009185 chain length determination region; other site 443150009186 substrate-Mg2+ binding site; other site 443150009187 catalytic residues [active] 443150009188 aspartate-rich region 1; other site 443150009189 active site lid residues [active] 443150009190 aspartate-rich region 2; other site 443150009191 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 443150009192 putative active site [active] 443150009193 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 443150009194 Transposase domain (DUF772); Region: DUF772; pfam05598 443150009195 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 443150009196 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 443150009197 PE family; Region: PE; pfam00934 443150009198 enoyl-CoA hydratase; Region: PLN02864 443150009199 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 443150009200 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 443150009201 dimer interaction site [polypeptide binding]; other site 443150009202 substrate-binding tunnel; other site 443150009203 active site 443150009204 catalytic site [active] 443150009205 substrate binding site [chemical binding]; other site 443150009206 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 443150009207 short chain dehydrogenase; Provisional; Region: PRK07201 443150009208 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 443150009209 putative NAD(P) binding site [chemical binding]; other site 443150009210 active site 443150009211 putative substrate binding site [chemical binding]; other site 443150009212 classical (c) SDRs; Region: SDR_c; cd05233 443150009213 NAD(P) binding site [chemical binding]; other site 443150009214 active site 443150009215 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 443150009216 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443150009217 S-adenosylmethionine binding site [chemical binding]; other site 443150009218 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 443150009219 active site 443150009220 DNA Polymerase Y-family; Region: PolY_like; cd03468 443150009221 DNA binding site [nucleotide binding] 443150009222 GMP synthase; Reviewed; Region: guaA; PRK00074 443150009223 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 443150009224 AMP/PPi binding site [chemical binding]; other site 443150009225 candidate oxyanion hole; other site 443150009226 catalytic triad [active] 443150009227 potential glutamine specificity residues [chemical binding]; other site 443150009228 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 443150009229 ATP Binding subdomain [chemical binding]; other site 443150009230 Ligand Binding sites [chemical binding]; other site 443150009231 Dimerization subdomain; other site 443150009232 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 443150009233 active site lid residues [active] 443150009234 substrate binding pocket [chemical binding]; other site 443150009235 catalytic residues [active] 443150009236 substrate-Mg2+ binding site; other site 443150009237 aspartate-rich region 1; other site 443150009238 aspartate-rich region 2; other site 443150009239 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 443150009240 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 443150009241 substrate binding pocket [chemical binding]; other site 443150009242 chain length determination region; other site 443150009243 substrate-Mg2+ binding site; other site 443150009244 catalytic residues [active] 443150009245 aspartate-rich region 1; other site 443150009246 active site lid residues [active] 443150009247 aspartate-rich region 2; other site 443150009248 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 443150009249 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 443150009250 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 443150009251 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 443150009252 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 443150009253 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 443150009254 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 443150009255 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 443150009256 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 443150009257 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 443150009258 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443150009259 catalytic residue [active] 443150009260 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 443150009261 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 443150009262 hypothetical protein; Provisional; Region: PRK07579 443150009263 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 443150009264 active site 443150009265 cosubstrate binding site; other site 443150009266 substrate binding site [chemical binding]; other site 443150009267 catalytic site [active] 443150009268 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443150009269 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443150009270 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 443150009271 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 443150009272 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 443150009273 putative active site [active] 443150009274 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 443150009275 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 443150009276 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 443150009277 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 443150009278 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 443150009279 phosphate binding site [ion binding]; other site 443150009280 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 443150009281 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 443150009282 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 443150009283 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 443150009284 active site 443150009285 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 443150009286 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443150009287 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 443150009288 DNA binding residues [nucleotide binding] 443150009289 Transcription factor WhiB; Region: Whib; pfam02467 443150009290 potential frameshift: common BLAST hit: gi|378773203|ref|YP_005172936.1| 60 kDa chaperonin 2 443150009291 chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777 443150009292 chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777 443150009293 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 443150009294 oligomerisation interface [polypeptide binding]; other site 443150009295 mobile loop; other site 443150009296 roof hairpin; other site 443150009297 UGMP family protein; Validated; Region: PRK09604 443150009298 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 443150009299 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 443150009300 Coenzyme A binding pocket [chemical binding]; other site 443150009301 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 443150009302 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 443150009303 alanine racemase; Reviewed; Region: alr; PRK00053 443150009304 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 443150009305 active site 443150009306 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 443150009307 dimer interface [polypeptide binding]; other site 443150009308 substrate binding site [chemical binding]; other site 443150009309 catalytic residues [active] 443150009310 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150009311 PPE family; Region: PPE; pfam00823 443150009312 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 443150009313 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443150009314 Walker A motif; other site 443150009315 ATP binding site [chemical binding]; other site 443150009316 Walker B motif; other site 443150009317 arginine finger; other site 443150009318 putative transposase OrfB; Reviewed; Region: PHA02517 443150009319 HTH-like domain; Region: HTH_21; pfam13276 443150009320 Integrase core domain; Region: rve; pfam00665 443150009321 Integrase core domain; Region: rve_3; pfam13683 443150009322 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 443150009323 Integrase core domain; Region: rve; pfam00665 443150009324 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150009325 PPE family; Region: PPE; pfam00823 443150009326 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 443150009327 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150009328 PPE family; Region: PPE; pfam00823 443150009329 Integrase core domain; Region: rve; pfam00665 443150009330 Integrase core domain; Region: rve_3; pfam13683 443150009331 Transposase, Mutator family; Region: Transposase_mut; pfam00872 443150009332 MULE transposase domain; Region: MULE; pfam10551 443150009333 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 443150009334 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443150009335 catalytic residue [active] 443150009336 Uncharacterized conserved protein [Function unknown]; Region: COG0062 443150009337 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 443150009338 putative substrate binding site [chemical binding]; other site 443150009339 putative ATP binding site [chemical binding]; other site 443150009340 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 443150009341 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 443150009342 glutaminase active site [active] 443150009343 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 443150009344 dimer interface [polypeptide binding]; other site 443150009345 active site 443150009346 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 443150009347 dimer interface [polypeptide binding]; other site 443150009348 active site 443150009349 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 443150009350 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 443150009351 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 443150009352 active site 443150009353 substrate binding site [chemical binding]; other site 443150009354 metal binding site [ion binding]; metal-binding site 443150009355 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 443150009356 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 443150009357 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 443150009358 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 443150009359 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 443150009360 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 443150009361 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 443150009362 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 443150009363 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 443150009364 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 443150009365 potential frameshift: common BLAST hit: gi|378773231|ref|YP_005172964.1| putative secreted serine protease 443150009366 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 443150009367 active site 443150009368 catalytic residues [active] 443150009369 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 443150009370 catalytic residues [active] 443150009371 Protein of unknown function (DUF690); Region: DUF690; cl04939 443150009372 Cutinase; Region: Cutinase; pfam01083 443150009373 Cutinase; Region: Cutinase; pfam01083 443150009374 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 443150009375 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 443150009376 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 443150009377 active site 443150009378 dimerization interface 3.5A [polypeptide binding]; other site 443150009379 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 443150009380 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 443150009381 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 443150009382 alphaNTD - beta interaction site [polypeptide binding]; other site 443150009383 alphaNTD homodimer interface [polypeptide binding]; other site 443150009384 alphaNTD - beta' interaction site [polypeptide binding]; other site 443150009385 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 443150009386 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 443150009387 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 443150009388 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 443150009389 RNA binding surface [nucleotide binding]; other site 443150009390 30S ribosomal protein S11; Validated; Region: PRK05309 443150009391 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 443150009392 30S ribosomal protein S13; Region: bact_S13; TIGR03631 443150009393 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 443150009394 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 443150009395 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 443150009396 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 443150009397 NAD binding site [chemical binding]; other site 443150009398 substrate binding site [chemical binding]; other site 443150009399 homodimer interface [polypeptide binding]; other site 443150009400 active site 443150009401 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 443150009402 Domain of unknown function (DUF222); Region: DUF222; pfam02720 443150009403 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 443150009404 active site 443150009405 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 443150009406 extended (e) SDRs; Region: SDR_e; cd08946 443150009407 NAD(P) binding site [chemical binding]; other site 443150009408 active site 443150009409 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 443150009410 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 443150009411 active site 443150009412 catalytic residues [active] 443150009413 metal binding site [ion binding]; metal-binding site 443150009414 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 443150009415 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 443150009416 PYR/PP interface [polypeptide binding]; other site 443150009417 dimer interface [polypeptide binding]; other site 443150009418 TPP binding site [chemical binding]; other site 443150009419 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 443150009420 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 443150009421 TPP-binding site [chemical binding]; other site 443150009422 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 443150009423 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 443150009424 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443150009425 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 443150009426 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443150009427 metabolite-proton symporter; Region: 2A0106; TIGR00883 443150009428 putative substrate translocation pore; other site 443150009429 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150009430 PPE family; Region: PPE; pfam00823 443150009431 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 443150009432 patatin-related protein; Region: TIGR03607 443150009433 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443150009434 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443150009435 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 443150009436 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 443150009437 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 443150009438 Transcriptional regulator [Transcription]; Region: LytR; COG1316 443150009439 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 443150009440 short chain dehydrogenase; Provisional; Region: PRK05875 443150009441 classical (c) SDRs; Region: SDR_c; cd05233 443150009442 NAD(P) binding site [chemical binding]; other site 443150009443 active site 443150009444 Predicted membrane protein [Function unknown]; Region: COG2259 443150009445 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 443150009446 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 443150009447 Predicted transcriptional regulators [Transcription]; Region: COG1695 443150009448 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 443150009449 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 443150009450 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 443150009451 active site 443150009452 homotetramer interface [polypeptide binding]; other site 443150009453 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443150009454 mce related protein; Region: MCE; pfam02470 443150009455 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443150009456 mce related protein; Region: MCE; pfam02470 443150009457 mce related protein; Region: MCE; pfam02470 443150009458 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443150009459 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 443150009460 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443150009461 mce related protein; Region: MCE; pfam02470 443150009462 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443150009463 mce related protein; Region: MCE; pfam02470 443150009464 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443150009465 mce related protein; Region: MCE; pfam02470 443150009466 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 443150009467 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 443150009468 Permease; Region: Permease; pfam02405 443150009469 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 443150009470 Permease; Region: Permease; pfam02405 443150009471 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 443150009472 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443150009473 NAD(P) binding site [chemical binding]; other site 443150009474 active site 443150009475 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443150009476 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 443150009477 FAD binding site [chemical binding]; other site 443150009478 substrate binding site [chemical binding]; other site 443150009479 catalytic base [active] 443150009480 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443150009481 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443150009482 active site 443150009483 acyl-CoA synthetase; Validated; Region: PRK07867 443150009484 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 443150009485 acyl-activating enzyme (AAE) consensus motif; other site 443150009486 putative AMP binding site [chemical binding]; other site 443150009487 putative active site [active] 443150009488 putative CoA binding site [chemical binding]; other site 443150009489 potential frameshift: common BLAST hit: gi|375297775|ref|YP_005102042.1| PE-PGRS family protein 443150009490 PE family; Region: PE; pfam00934 443150009491 PE family; Region: PE; pfam00934 443150009492 hypothetical protein; Validated; Region: PRK07586 443150009493 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 443150009494 PYR/PP interface [polypeptide binding]; other site 443150009495 dimer interface [polypeptide binding]; other site 443150009496 TPP binding site [chemical binding]; other site 443150009497 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 443150009498 TPP-binding site [chemical binding]; other site 443150009499 dimer interface [polypeptide binding]; other site 443150009500 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 443150009501 PE family; Region: PE; pfam00934 443150009502 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443150009503 CoA binding site [chemical binding]; other site 443150009504 PE family; Region: PE; pfam00934 443150009505 acyl-CoA synthetase; Validated; Region: PRK07798 443150009506 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443150009507 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 443150009508 acyl-activating enzyme (AAE) consensus motif; other site 443150009509 acyl-activating enzyme (AAE) consensus motif; other site 443150009510 putative AMP binding site [chemical binding]; other site 443150009511 putative active site [active] 443150009512 putative CoA binding site [chemical binding]; other site 443150009513 enoyl-CoA hydratase; Provisional; Region: PRK07799 443150009514 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443150009515 substrate binding site [chemical binding]; other site 443150009516 oxyanion hole (OAH) forming residues; other site 443150009517 trimer interface [polypeptide binding]; other site 443150009518 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 443150009519 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443150009520 Cytochrome P450; Region: p450; cl12078 443150009521 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 443150009522 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 443150009523 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 443150009524 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 443150009525 DUF35 OB-fold domain; Region: DUF35; pfam01796 443150009526 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 443150009527 DUF35 OB-fold domain; Region: DUF35; pfam01796 443150009528 lipid-transfer protein; Provisional; Region: PRK07937 443150009529 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 443150009530 active site 443150009531 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 443150009532 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 443150009533 active site 443150009534 NHL repeat; Region: NHL; pfam01436 443150009535 Uncharacterized conserved protein [Function unknown]; Region: COG3391 443150009536 NHL repeat; Region: NHL; pfam01436 443150009537 NHL repeat; Region: NHL; pfam01436 443150009538 NHL repeat; Region: NHL; pfam01436 443150009539 NHL repeat; Region: NHL; pfam01436 443150009540 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 443150009541 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 443150009542 trimer interface [polypeptide binding]; other site 443150009543 putative metal binding site [ion binding]; other site 443150009544 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 443150009545 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 443150009546 iron-sulfur cluster [ion binding]; other site 443150009547 [2Fe-2S] cluster binding site [ion binding]; other site 443150009548 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 443150009549 short chain dehydrogenase; Provisional; Region: PRK07890 443150009550 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443150009551 NAD(P) binding site [chemical binding]; other site 443150009552 active site 443150009553 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150009554 PPE family; Region: PPE; pfam00823 443150009555 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 443150009556 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150009557 PPE family; Region: PPE; pfam00823 443150009558 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443150009559 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443150009560 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 443150009561 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 443150009562 active site 443150009563 catalytic residues [active] 443150009564 metal binding site [ion binding]; metal-binding site 443150009565 DmpG-like communication domain; Region: DmpG_comm; pfam07836 443150009566 acetaldehyde dehydrogenase; Validated; Region: PRK08300 443150009567 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 443150009568 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 443150009569 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971 443150009570 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 443150009571 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 443150009572 enoyl-CoA hydratase; Region: PLN02864 443150009573 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 443150009574 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 443150009575 dimer interaction site [polypeptide binding]; other site 443150009576 substrate-binding tunnel; other site 443150009577 active site 443150009578 catalytic site [active] 443150009579 substrate binding site [chemical binding]; other site 443150009580 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150009581 PPE family; Region: PPE; pfam00823 443150009582 PE-PPE domain; Region: PE-PPE; pfam08237 443150009583 lipid-transfer protein; Provisional; Region: PRK07855 443150009584 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 443150009585 active site 443150009586 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 443150009587 putative active site [active] 443150009588 putative catalytic site [active] 443150009589 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 443150009590 active site 443150009591 catalytic site [active] 443150009592 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 443150009593 DUF35 OB-fold domain; Region: DUF35; pfam01796 443150009594 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443150009595 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443150009596 active site 443150009597 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443150009598 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 443150009599 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443150009600 active site 443150009601 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443150009602 Cytochrome P450; Region: p450; cl12078 443150009603 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 443150009604 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 443150009605 dimer interface [polypeptide binding]; other site 443150009606 active site 443150009607 Domain of unknown function (DUF385); Region: DUF385; pfam04075 443150009608 short chain dehydrogenase; Provisional; Region: PRK07791 443150009609 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 443150009610 homodimer interface [polypeptide binding]; other site 443150009611 NAD binding site [chemical binding]; other site 443150009612 active site 443150009613 short chain dehydrogenase; Provisional; Region: PRK07856 443150009614 classical (c) SDRs; Region: SDR_c; cd05233 443150009615 NAD(P) binding site [chemical binding]; other site 443150009616 active site 443150009617 enoyl-CoA hydratase; Provisional; Region: PRK06495 443150009618 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443150009619 substrate binding site [chemical binding]; other site 443150009620 oxyanion hole (OAH) forming residues; other site 443150009621 trimer interface [polypeptide binding]; other site 443150009622 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 443150009623 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057 443150009624 Nitronate monooxygenase; Region: NMO; pfam03060 443150009625 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 443150009626 FMN binding site [chemical binding]; other site 443150009627 substrate binding site [chemical binding]; other site 443150009628 putative catalytic residue [active] 443150009629 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 443150009630 Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514 443150009631 putative di-iron ligands [ion binding]; other site 443150009632 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 443150009633 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 443150009634 FAD binding pocket [chemical binding]; other site 443150009635 FAD binding motif [chemical binding]; other site 443150009636 phosphate binding motif [ion binding]; other site 443150009637 beta-alpha-beta structure motif; other site 443150009638 NAD(p) ribose binding residues [chemical binding]; other site 443150009639 NAD binding pocket [chemical binding]; other site 443150009640 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 443150009641 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443150009642 catalytic loop [active] 443150009643 iron binding site [ion binding]; other site 443150009644 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 443150009645 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 443150009646 putative active site [active] 443150009647 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 443150009648 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 443150009649 dimer interface [polypeptide binding]; other site 443150009650 active site 443150009651 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443150009652 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443150009653 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150009654 PPE family; Region: PPE; pfam00823 443150009655 short chain dehydrogenase; Provisional; Region: PRK07831 443150009656 classical (c) SDRs; Region: SDR_c; cd05233 443150009657 NAD(P) binding site [chemical binding]; other site 443150009658 active site 443150009659 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443150009660 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443150009661 active site 443150009662 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 443150009663 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443150009664 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 443150009665 acyl-activating enzyme (AAE) consensus motif; other site 443150009666 putative AMP binding site [chemical binding]; other site 443150009667 putative active site [active] 443150009668 putative CoA binding site [chemical binding]; other site 443150009669 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443150009670 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443150009671 active site 443150009672 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443150009673 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 443150009674 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443150009675 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443150009676 active site 443150009677 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 443150009678 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443150009679 active site 443150009680 aspartate aminotransferase; Provisional; Region: PRK05764 443150009681 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443150009682 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443150009683 homodimer interface [polypeptide binding]; other site 443150009684 catalytic residue [active] 443150009685 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 443150009686 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 443150009687 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 443150009688 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 443150009689 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 443150009690 active site 443150009691 Fe binding site [ion binding]; other site 443150009692 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 443150009693 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443150009694 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 443150009695 Flavin binding site [chemical binding]; other site 443150009696 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 443150009697 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 443150009698 FAD binding pocket [chemical binding]; other site 443150009699 FAD binding motif [chemical binding]; other site 443150009700 phosphate binding motif [ion binding]; other site 443150009701 beta-alpha-beta structure motif; other site 443150009702 NAD(p) ribose binding residues [chemical binding]; other site 443150009703 NAD binding pocket [chemical binding]; other site 443150009704 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 443150009705 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 443150009706 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443150009707 catalytic loop [active] 443150009708 iron binding site [ion binding]; other site 443150009709 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443150009710 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443150009711 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443150009712 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443150009713 active site 443150009714 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443150009715 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443150009716 Transcriptional regulators [Transcription]; Region: PurR; COG1609 443150009717 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 443150009718 DNA binding site [nucleotide binding] 443150009719 domain linker motif; other site 443150009720 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 443150009721 putative dimerization interface [polypeptide binding]; other site 443150009722 putative ligand binding site [chemical binding]; other site 443150009723 PknH-like extracellular domain; Region: PknH_C; pfam14032 443150009724 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 443150009725 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 443150009726 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 443150009727 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 443150009728 transmembrane helices; other site 443150009729 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 443150009730 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 443150009731 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 443150009732 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 443150009733 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 443150009734 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 443150009735 active site 443150009736 HIGH motif; other site 443150009737 nucleotide binding site [chemical binding]; other site 443150009738 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 443150009739 KMSKS motif; other site 443150009740 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 443150009741 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 443150009742 homotrimer interaction site [polypeptide binding]; other site 443150009743 zinc binding site [ion binding]; other site 443150009744 CDP-binding sites; other site 443150009745 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 443150009746 substrate binding site; other site 443150009747 dimer interface; other site 443150009748 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 443150009749 DNA repair protein RadA; Provisional; Region: PRK11823 443150009750 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 443150009751 Walker A motif; other site 443150009752 ATP binding site [chemical binding]; other site 443150009753 Walker B motif; other site 443150009754 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 443150009755 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 443150009756 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 443150009757 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 443150009758 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 443150009759 active site clefts [active] 443150009760 zinc binding site [ion binding]; other site 443150009761 dimer interface [polypeptide binding]; other site 443150009762 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 443150009763 helix-hairpin-helix signature motif; other site 443150009764 substrate binding pocket [chemical binding]; other site 443150009765 active site 443150009766 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 443150009767 PE family; Region: PE; pfam00934 443150009768 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443150009769 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 443150009770 catalytic site [active] 443150009771 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 443150009772 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 443150009773 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 443150009774 Ami_2 domain; Region: Ami_2; smart00644 443150009775 amidase catalytic site [active] 443150009776 Zn binding residues [ion binding]; other site 443150009777 substrate binding site [chemical binding]; other site 443150009778 PE family; Region: PE; pfam00934 443150009779 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 443150009780 Clp amino terminal domain; Region: Clp_N; pfam02861 443150009781 Clp amino terminal domain; Region: Clp_N; pfam02861 443150009782 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443150009783 Walker A motif; other site 443150009784 ATP binding site [chemical binding]; other site 443150009785 Walker B motif; other site 443150009786 arginine finger; other site 443150009787 UvrB/uvrC motif; Region: UVR; pfam02151 443150009788 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443150009789 Walker A motif; other site 443150009790 ATP binding site [chemical binding]; other site 443150009791 Walker B motif; other site 443150009792 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 443150009793 Lsr2; Region: Lsr2; pfam11774 443150009794 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 443150009795 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 443150009796 dimer interface [polypeptide binding]; other site 443150009797 putative anticodon binding site; other site 443150009798 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 443150009799 motif 1; other site 443150009800 dimer interface [polypeptide binding]; other site 443150009801 active site 443150009802 motif 2; other site 443150009803 motif 3; other site 443150009804 pantothenate kinase; Reviewed; Region: PRK13318 443150009805 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 443150009806 tetramerization interface [polypeptide binding]; other site 443150009807 active site 443150009808 Pantoate-beta-alanine ligase; Region: PanC; cd00560 443150009809 pantoate--beta-alanine ligase; Region: panC; TIGR00018 443150009810 active site 443150009811 ATP-binding site [chemical binding]; other site 443150009812 pantoate-binding site; other site 443150009813 HXXH motif; other site 443150009814 Rossmann-like domain; Region: Rossmann-like; pfam10727 443150009815 Uncharacterized conserved protein [Function unknown]; Region: COG5495 443150009816 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 443150009817 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 443150009818 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 443150009819 catalytic center binding site [active] 443150009820 ATP binding site [chemical binding]; other site 443150009821 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 443150009822 homooctamer interface [polypeptide binding]; other site 443150009823 active site 443150009824 dihydropteroate synthase; Region: DHPS; TIGR01496 443150009825 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 443150009826 substrate binding pocket [chemical binding]; other site 443150009827 dimer interface [polypeptide binding]; other site 443150009828 inhibitor binding site; inhibition site 443150009829 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 443150009830 homodecamer interface [polypeptide binding]; other site 443150009831 GTP cyclohydrolase I; Provisional; Region: PLN03044 443150009832 active site 443150009833 putative catalytic site residues [active] 443150009834 zinc binding site [ion binding]; other site 443150009835 GTP-CH-I/GFRP interaction surface; other site 443150009836 FtsH Extracellular; Region: FtsH_ext; pfam06480 443150009837 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 443150009838 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443150009839 Walker A motif; other site 443150009840 ATP binding site [chemical binding]; other site 443150009841 Walker B motif; other site 443150009842 arginine finger; other site 443150009843 Peptidase family M41; Region: Peptidase_M41; pfam01434 443150009844 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 443150009845 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 443150009846 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443150009847 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 443150009848 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 443150009849 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 443150009850 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 443150009851 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150009852 PPE family; Region: PPE; pfam00823 443150009853 Uncharacterized conserved protein [Function unknown]; Region: COG2968 443150009854 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 443150009855 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 443150009856 active site 443150009857 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 443150009858 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 443150009859 Ligand Binding Site [chemical binding]; other site 443150009860 Uncharacterized conserved protein [Function unknown]; Region: COG5282 443150009861 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 443150009862 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113 443150009863 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 443150009864 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 443150009865 dimer interface [polypeptide binding]; other site 443150009866 substrate binding site [chemical binding]; other site 443150009867 metal binding sites [ion binding]; metal-binding site 443150009868 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2899 443150009869 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 443150009870 Putative Catalytic site; other site 443150009871 DXD motif; other site 443150009872 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 443150009873 Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5285 443150009874 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 443150009875 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443150009876 NAD(P) binding site [chemical binding]; other site 443150009877 active site 443150009878 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 443150009879 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 443150009880 Integrase core domain; Region: rve; pfam00665 443150009881 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 443150009882 transposase; Provisional; Region: PRK06526 443150009883 IstB-like ATP binding protein; Region: IstB_IS21; pfam01695 443150009884 Walker B motif; other site 443150009885 Transposase, Mutator family; Region: Transposase_mut; pfam00872 443150009886 MULE transposase domain; Region: MULE; pfam10551 443150009887 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 443150009888 Fic/DOC family; Region: Fic; cl00960 443150009889 DNA polymerase III subunit delta'; Validated; Region: PRK07940 443150009890 DNA polymerase III subunit delta'; Validated; Region: PRK08485 443150009891 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443150009892 dimerization interface [polypeptide binding]; other site 443150009893 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 443150009894 cyclase homology domain; Region: CHD; cd07302 443150009895 nucleotidyl binding site; other site 443150009896 metal binding site [ion binding]; metal-binding site 443150009897 dimer interface [polypeptide binding]; other site 443150009898 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 443150009899 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 443150009900 active site 443150009901 interdomain interaction site; other site 443150009902 putative metal-binding site [ion binding]; other site 443150009903 nucleotide binding site [chemical binding]; other site 443150009904 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 443150009905 domain I; other site 443150009906 phosphate binding site [ion binding]; other site 443150009907 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 443150009908 domain II; other site 443150009909 domain III; other site 443150009910 nucleotide binding site [chemical binding]; other site 443150009911 DNA binding groove [nucleotide binding] 443150009912 catalytic site [active] 443150009913 domain IV; other site 443150009914 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 443150009915 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 443150009916 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 443150009917 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 443150009918 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443150009919 ATP binding site [chemical binding]; other site 443150009920 putative Mg++ binding site [ion binding]; other site 443150009921 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443150009922 nucleotide binding region [chemical binding]; other site 443150009923 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 443150009924 PE family; Region: PE; pfam00934 443150009925 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 443150009926 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 443150009927 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 443150009928 Walker A motif; other site 443150009929 ATP binding site [chemical binding]; other site 443150009930 Walker B motif; other site 443150009931 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 443150009932 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 443150009933 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443150009934 motif II; other site 443150009935 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 443150009936 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 443150009937 Walker A/P-loop; other site 443150009938 ATP binding site [chemical binding]; other site 443150009939 Q-loop/lid; other site 443150009940 ABC transporter signature motif; other site 443150009941 Walker B; other site 443150009942 D-loop; other site 443150009943 H-loop/switch region; other site 443150009944 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 443150009945 Walker A/P-loop; other site 443150009946 ATP binding site [chemical binding]; other site 443150009947 Q-loop/lid; other site 443150009948 ABC transporter signature motif; other site 443150009949 Walker B; other site 443150009950 D-loop; other site 443150009951 H-loop/switch region; other site 443150009952 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 443150009953 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 443150009954 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443150009955 ABC-ATPase subunit interface; other site 443150009956 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 443150009957 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443150009958 dimer interface [polypeptide binding]; other site 443150009959 conserved gate region; other site 443150009960 putative PBP binding loops; other site 443150009961 ABC-ATPase subunit interface; other site 443150009962 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 443150009963 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 443150009964 acetyl-CoA synthetase; Provisional; Region: PRK00174 443150009965 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 443150009966 active site 443150009967 CoA binding site [chemical binding]; other site 443150009968 acyl-activating enzyme (AAE) consensus motif; other site 443150009969 AMP binding site [chemical binding]; other site 443150009970 acetate binding site [chemical binding]; other site 443150009971 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 443150009972 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443150009973 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 443150009974 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 443150009975 putative active site [active] 443150009976 putative CoA binding site [chemical binding]; other site 443150009977 nudix motif; other site 443150009978 metal binding site [ion binding]; metal-binding site 443150009979 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 443150009980 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 443150009981 catalytic residues [active] 443150009982 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 443150009983 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 443150009984 minor groove reading motif; other site 443150009985 helix-hairpin-helix signature motif; other site 443150009986 substrate binding pocket [chemical binding]; other site 443150009987 active site 443150009988 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 443150009989 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 443150009990 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 443150009991 ligand binding site [chemical binding]; other site 443150009992 flexible hinge region; other site 443150009993 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 443150009994 putative switch regulator; other site 443150009995 non-specific DNA interactions [nucleotide binding]; other site 443150009996 DNA binding site [nucleotide binding] 443150009997 sequence specific DNA binding site [nucleotide binding]; other site 443150009998 putative cAMP binding site [chemical binding]; other site 443150009999 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 443150010000 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 443150010001 homotrimer interaction site [polypeptide binding]; other site 443150010002 putative active site [active] 443150010003 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 443150010004 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 443150010005 P loop; other site 443150010006 Nucleotide binding site [chemical binding]; other site 443150010007 DTAP/Switch II; other site 443150010008 Switch I; other site 443150010009 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 443150010010 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 443150010011 DTAP/Switch II; other site 443150010012 Switch I; other site 443150010013 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 443150010014 Transcription factor WhiB; Region: Whib; pfam02467 443150010015 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 443150010016 Transglycosylase; Region: Transgly; pfam00912 443150010017 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 443150010018 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 443150010019 phosphodiesterase YaeI; Provisional; Region: PRK11340 443150010020 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 443150010021 putative active site [active] 443150010022 putative metal binding site [ion binding]; other site 443150010023 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 443150010024 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 443150010025 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443150010026 catalytic residue [active] 443150010027 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443150010028 Cytochrome P450; Region: p450; cl12078 443150010029 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 443150010030 anti sigma factor interaction site; other site 443150010031 regulatory phosphorylation site [posttranslational modification]; other site 443150010032 Uncharacterized conserved protein [Function unknown]; Region: COG1610 443150010033 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 443150010034 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 443150010035 MoxR-like ATPases [General function prediction only]; Region: COG0714 443150010036 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443150010037 Walker A motif; other site 443150010038 ATP binding site [chemical binding]; other site 443150010039 Walker B motif; other site 443150010040 arginine finger; other site 443150010041 potential frameshift: common BLAST hit: gi|378773470|ref|YP_005173203.1| membrane protein 443150010042 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 443150010043 Protein of unknown function DUF58; Region: DUF58; pfam01882 443150010044 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 443150010045 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 443150010046 Predicted membrane protein/domain [Function unknown]; Region: COG1714 443150010047 glycerol kinase; Provisional; Region: glpK; PRK00047 443150010048 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 443150010049 nucleotide binding site [chemical binding]; other site 443150010050 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 443150010051 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 443150010052 Methyltransferase domain; Region: Methyltransf_23; pfam13489 443150010053 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443150010054 S-adenosylmethionine binding site [chemical binding]; other site 443150010055 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 443150010056 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 443150010057 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443150010058 catalytic residue [active] 443150010059 Uncharacterized conserved protein [Function unknown]; Region: COG4301 443150010060 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 443150010061 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 443150010062 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 443150010063 putative dimer interface [polypeptide binding]; other site 443150010064 putative active site [active] 443150010065 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 443150010066 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 443150010067 Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG3572 443150010068 PknH-like extracellular domain; Region: PknH_C; pfam14032 443150010069 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 443150010070 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 443150010071 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 443150010072 aspartate kinase; Reviewed; Region: PRK06635 443150010073 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 443150010074 putative nucleotide binding site [chemical binding]; other site 443150010075 putative catalytic residues [active] 443150010076 putative Mg ion binding site [ion binding]; other site 443150010077 putative aspartate binding site [chemical binding]; other site 443150010078 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 443150010079 putative allosteric regulatory site; other site 443150010080 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 443150010081 putative allosteric regulatory residue; other site 443150010082 2-isopropylmalate synthase; Validated; Region: PRK03739 443150010083 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 443150010084 active site 443150010085 catalytic residues [active] 443150010086 metal binding site [ion binding]; metal-binding site 443150010087 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 443150010088 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 443150010089 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 443150010090 active site 443150010091 catalytic site [active] 443150010092 substrate binding site [chemical binding]; other site 443150010093 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 443150010094 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 443150010095 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 443150010096 catalytic triad [active] 443150010097 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 443150010098 putative active site [active] 443150010099 recombination protein RecR; Reviewed; Region: recR; PRK00076 443150010100 RecR protein; Region: RecR; pfam02132 443150010101 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 443150010102 putative active site [active] 443150010103 putative metal-binding site [ion binding]; other site 443150010104 tetramer interface [polypeptide binding]; other site 443150010105 hypothetical protein; Validated; Region: PRK00153 443150010106 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 443150010107 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 443150010108 active site 443150010109 metal binding site [ion binding]; metal-binding site 443150010110 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 443150010111 hydrophobic ligand binding site; other site 443150010112 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 443150010113 FAD binding domain; Region: FAD_binding_4; pfam01565 443150010114 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 443150010115 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443150010116 S-adenosylmethionine binding site [chemical binding]; other site 443150010117 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14952 443150010118 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443150010119 Walker A motif; other site 443150010120 ATP binding site [chemical binding]; other site 443150010121 Walker B motif; other site 443150010122 arginine finger; other site 443150010123 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 443150010124 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 443150010125 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 443150010126 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443150010127 catalytic residue [active] 443150010128 Cutinase; Region: Cutinase; pfam01083 443150010129 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 443150010130 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443150010131 NAD(P) binding site [chemical binding]; other site 443150010132 active site 443150010133 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 443150010134 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 443150010135 putative NAD(P) binding site [chemical binding]; other site 443150010136 catalytic Zn binding site [ion binding]; other site 443150010137 Uncharacterized conserved protein [Function unknown]; Region: COG3349 443150010138 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 443150010139 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 443150010140 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443150010141 putative substrate translocation pore; other site 443150010142 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 443150010143 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 443150010144 ligand binding site [chemical binding]; other site 443150010145 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 443150010146 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 443150010147 active site 443150010148 nucleophile elbow; other site 443150010149 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 443150010150 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443150010151 FeS/SAM binding site; other site 443150010152 Methyltransferase domain; Region: Methyltransf_31; pfam13847 443150010153 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443150010154 S-adenosylmethionine binding site [chemical binding]; other site 443150010155 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 443150010156 nucleotide binding site [chemical binding]; other site 443150010157 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 443150010158 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 443150010159 active site 443150010160 DNA binding site [nucleotide binding] 443150010161 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 443150010162 DNA binding site [nucleotide binding] 443150010163 Uncharacterized protein conserved in bacteria (DUF2330); Region: DUF2330; cl01827 443150010164 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_5; cd04662 443150010165 nudix motif; other site 443150010166 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443150010167 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443150010168 Uncharacterized conserved protein [Function unknown]; Region: COG1839 443150010169 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 443150010170 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 443150010171 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 443150010172 Uncharacterized conserved protein [Function unknown]; Region: COG2966 443150010173 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 443150010174 Uncharacterized conserved protein [Function unknown]; Region: COG3610 443150010175 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150010176 PPE family; Region: PPE; pfam00823 443150010177 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443150010178 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443150010179 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 443150010180 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 443150010181 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 443150010182 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 443150010183 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 443150010184 Soluble P-type ATPase [General function prediction only]; Region: COG4087 443150010185 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443150010186 dimerization interface [polypeptide binding]; other site 443150010187 putative DNA binding site [nucleotide binding]; other site 443150010188 putative Zn2+ binding site [ion binding]; other site 443150010189 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 443150010190 DNA binding domain, excisionase family; Region: excise; TIGR01764 443150010191 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 443150010192 nucleoside/Zn binding site; other site 443150010193 dimer interface [polypeptide binding]; other site 443150010194 catalytic motif [active] 443150010195 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 443150010196 prephenate dehydrogenase; Validated; Region: PRK06545 443150010197 prephenate dehydrogenase; Validated; Region: PRK08507 443150010198 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3554 443150010199 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443150010200 ABC-ATPase subunit interface; other site 443150010201 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 443150010202 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 443150010203 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 443150010204 Walker A/P-loop; other site 443150010205 ATP binding site [chemical binding]; other site 443150010206 Q-loop/lid; other site 443150010207 ABC transporter signature motif; other site 443150010208 Walker B; other site 443150010209 D-loop; other site 443150010210 H-loop/switch region; other site 443150010211 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 443150010212 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 443150010213 putative active site [active] 443150010214 putative substrate binding site [chemical binding]; other site 443150010215 ATP binding site [chemical binding]; other site 443150010216 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 443150010217 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 443150010218 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 443150010219 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443150010220 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 443150010221 dimerization interface [polypeptide binding]; other site 443150010222 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443150010223 dimer interface [polypeptide binding]; other site 443150010224 phosphorylation site [posttranslational modification] 443150010225 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443150010226 ATP binding site [chemical binding]; other site 443150010227 Mg2+ binding site [ion binding]; other site 443150010228 G-X-G motif; other site 443150010229 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 443150010230 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443150010231 active site 443150010232 phosphorylation site [posttranslational modification] 443150010233 intermolecular recognition site; other site 443150010234 dimerization interface [polypeptide binding]; other site 443150010235 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443150010236 DNA binding site [nucleotide binding] 443150010237 Photosystem II reaction centre W protein (PsbW); Region: PsbW; cl06243 443150010238 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 443150010239 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 443150010240 SnoaL-like domain; Region: SnoaL_2; pfam12680 443150010241 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 443150010242 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443150010243 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443150010244 homodimer interface [polypeptide binding]; other site 443150010245 catalytic residue [active] 443150010246 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 443150010247 TIGR03086 family protein; Region: TIGR03086 443150010248 enoyl-CoA hydratase; Provisional; Region: PRK06142 443150010249 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443150010250 substrate binding site [chemical binding]; other site 443150010251 oxyanion hole (OAH) forming residues; other site 443150010252 trimer interface [polypeptide binding]; other site 443150010253 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 443150010254 Beta-lactamase; Region: Beta-lactamase; pfam00144 443150010255 potential protein location (hypothetical protein CCDC5180_3454 [Mycobacterium tuberculosis CCDC5180]) that overlaps RNA (tRNA-S) 443150010256 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 443150010257 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 443150010258 NAD(P) binding site [chemical binding]; other site 443150010259 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 443150010260 cysteine desulfurase family protein, VC1184 subfamily; Region: am_tr_V_VC1184; TIGR01976 443150010261 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443150010262 catalytic residue [active] 443150010263 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 443150010264 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 443150010265 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 443150010266 Walker A/P-loop; other site 443150010267 ATP binding site [chemical binding]; other site 443150010268 Q-loop/lid; other site 443150010269 ABC transporter signature motif; other site 443150010270 Walker B; other site 443150010271 D-loop; other site 443150010272 H-loop/switch region; other site 443150010273 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 443150010274 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 443150010275 active site 443150010276 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 443150010277 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 443150010278 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 443150010279 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 443150010280 NAD binding site [chemical binding]; other site 443150010281 substrate binding site [chemical binding]; other site 443150010282 active site 443150010283 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 443150010284 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 443150010285 active site 443150010286 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 443150010287 Peptidase family M23; Region: Peptidase_M23; pfam01551 443150010288 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 443150010289 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 443150010290 Predicted membrane protein [Function unknown]; Region: COG2246 443150010291 GtrA-like protein; Region: GtrA; pfam04138 443150010292 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 443150010293 FAD binding domain; Region: FAD_binding_4; pfam01565 443150010294 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 443150010295 short chain dehydrogenase; Provisional; Region: PRK07904 443150010296 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 443150010297 NAD(P) binding site [chemical binding]; other site 443150010298 active site 443150010299 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 443150010300 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 443150010301 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 443150010302 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 443150010303 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 443150010304 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 443150010305 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 443150010306 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443150010307 FAD binding site [chemical binding]; other site 443150010308 substrate binding site [chemical binding]; other site 443150010309 catalytic residues [active] 443150010310 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 443150010311 Transposase; Region: DDE_Tnp_ISL3; pfam01610 443150010312 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 443150010313 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 443150010314 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 443150010315 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 443150010316 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 443150010317 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 443150010318 active site 443150010319 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 443150010320 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 443150010321 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 443150010322 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 443150010323 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 443150010324 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 443150010325 acyl-activating enzyme (AAE) consensus motif; other site 443150010326 active site 443150010327 Cutinase; Region: Cutinase; pfam01083 443150010328 Predicted esterase [General function prediction only]; Region: COG0627 443150010329 Putative esterase; Region: Esterase; pfam00756 443150010330 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 443150010331 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 443150010332 active site 443150010333 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 443150010334 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 443150010335 active site 443150010336 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 443150010337 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 443150010338 UDP-galactopyranose mutase; Region: GLF; pfam03275 443150010339 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 443150010340 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 443150010341 amidase catalytic site [active] 443150010342 Zn binding residues [ion binding]; other site 443150010343 substrate binding site [chemical binding]; other site 443150010344 LGFP repeat; Region: LGFP; pfam08310 443150010345 PE family; Region: PE; pfam00934 443150010346 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443150010347 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 443150010348 active site 443150010349 motif I; other site 443150010350 motif II; other site 443150010351 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 443150010352 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 443150010353 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 443150010354 putative acyl-acceptor binding pocket; other site 443150010355 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 443150010356 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 443150010357 putative acyl-acceptor binding pocket; other site 443150010358 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 443150010359 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 443150010360 putative acyl-acceptor binding pocket; other site 443150010361 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 443150010362 Phosphotransferase enzyme family; Region: APH; pfam01636 443150010363 active site 443150010364 ATP binding site [chemical binding]; other site 443150010365 antibiotic binding site [chemical binding]; other site 443150010366 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 443150010367 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 443150010368 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 443150010369 dimerization interface [polypeptide binding]; other site 443150010370 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 443150010371 iron-sulfur cluster [ion binding]; other site 443150010372 [2Fe-2S] cluster binding site [ion binding]; other site 443150010373 Condensation domain; Region: Condensation; pfam00668 443150010374 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 443150010375 PE-PPE domain; Region: PE-PPE; pfam08237 443150010376 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 443150010377 peptide synthase; Provisional; Region: PRK12316 443150010378 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 443150010379 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 443150010380 active site 443150010381 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 443150010382 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 443150010383 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443150010384 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 443150010385 Enoylreductase; Region: PKS_ER; smart00829 443150010386 NAD(P) binding site [chemical binding]; other site 443150010387 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 443150010388 KR domain; Region: KR; pfam08659 443150010389 putative NADP binding site [chemical binding]; other site 443150010390 active site 443150010391 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 443150010392 acyl-CoA synthetase; Validated; Region: PRK05850 443150010393 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 443150010394 acyl-activating enzyme (AAE) consensus motif; other site 443150010395 active site 443150010396 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 443150010397 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 443150010398 Probable transposase; Region: OrfB_IS605; pfam01385 443150010399 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 443150010400 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 443150010401 catalytic residues [active] 443150010402 catalytic nucleophile [active] 443150010403 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 443150010404 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443150010405 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 443150010406 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 443150010407 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 443150010408 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443150010409 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 443150010410 Cupin domain; Region: Cupin_2; cl17218 443150010411 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 443150010412 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 443150010413 seryl-tRNA synthetase; Provisional; Region: PRK05431 443150010414 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 443150010415 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 443150010416 dimer interface [polypeptide binding]; other site 443150010417 active site 443150010418 motif 1; other site 443150010419 motif 2; other site 443150010420 motif 3; other site 443150010421 Septum formation; Region: Septum_form; pfam13845 443150010422 Septum formation; Region: Septum_form; pfam13845 443150010423 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 443150010424 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 443150010425 catalytic core [active] 443150010426 prephenate dehydratase; Provisional; Region: PRK11898 443150010427 Prephenate dehydratase; Region: PDT; pfam00800 443150010428 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 443150010429 putative L-Phe binding site [chemical binding]; other site 443150010430 Transcriptional regulator [Transcription]; Region: LytR; COG1316 443150010431 Ferritin-like domain; Region: Ferritin; pfam00210 443150010432 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 443150010433 ferroxidase diiron center [ion binding]; other site 443150010434 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 443150010435 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 443150010436 putative active site [active] 443150010437 catalytic site [active] 443150010438 putative metal binding site [ion binding]; other site 443150010439 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 443150010440 Transposase; Region: DEDD_Tnp_IS110; pfam01548 443150010441 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 443150010442 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 443150010443 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 443150010444 Predicted membrane protein [Function unknown]; Region: COG2119 443150010445 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 443150010446 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 443150010447 Fimbrial protein; Region: Fimbrial; cl01416 443150010448 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 443150010449 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 443150010450 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 443150010451 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443150010452 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443150010453 hypothetical protein; Provisional; Region: PRK07945 443150010454 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 443150010455 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 443150010456 active site 443150010457 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 443150010458 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 443150010459 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 443150010460 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 443150010461 active site 443150010462 dimer interface [polypeptide binding]; other site 443150010463 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 443150010464 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 443150010465 active site 443150010466 FMN binding site [chemical binding]; other site 443150010467 substrate binding site [chemical binding]; other site 443150010468 3Fe-4S cluster binding site [ion binding]; other site 443150010469 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 443150010470 domain interface; other site 443150010471 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 443150010472 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 443150010473 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 443150010474 EspG family; Region: ESX-1_EspG; pfam14011 443150010475 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 443150010476 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443150010477 Walker A motif; other site 443150010478 ATP binding site [chemical binding]; other site 443150010479 Walker B motif; other site 443150010480 arginine finger; other site 443150010481 Protein of unknown function (DUF690); Region: DUF690; pfam05108 443150010482 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 443150010483 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 443150010484 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 443150010485 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 443150010486 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 443150010487 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443150010488 PPE family; Region: PPE; pfam00823 443150010489 Proteins of 100 residues with WXG; Region: WXG100; cl02005 443150010490 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 443150010491 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 443150010492 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 443150010493 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 443150010494 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 443150010495 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 443150010496 active site 443150010497 catalytic residues [active] 443150010498 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 443150010499 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443150010500 Walker A motif; other site 443150010501 ATP binding site [chemical binding]; other site 443150010502 Walker B motif; other site 443150010503 arginine finger; other site 443150010504 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 443150010505 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 443150010506 catalytic residues [active] 443150010507 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 443150010508 active site 443150010509 catalytic residues [active] 443150010510 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 443150010511 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 443150010512 EspG family; Region: ESX-1_EspG; pfam14011 443150010513 PPE family; Region: PPE; pfam00823 443150010514 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 443150010515 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 443150010516 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 443150010517 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 443150010518 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 443150010519 Protein of unknown function (DUF690); Region: DUF690; pfam05108 443150010520 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 443150010521 N-acetyl-D-glucosamine binding site [chemical binding]; other site 443150010522 catalytic residue [active] 443150010523 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 443150010524 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 443150010525 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 443150010526 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 443150010527 active site 443150010528 NTP binding site [chemical binding]; other site 443150010529 metal binding triad [ion binding]; metal-binding site 443150010530 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 443150010531 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443150010532 Zn2+ binding site [ion binding]; other site 443150010533 Mg2+ binding site [ion binding]; other site 443150010534 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 443150010535 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 443150010536 active site 443150010537 Ap6A binding site [chemical binding]; other site 443150010538 nudix motif; other site 443150010539 metal binding site [ion binding]; metal-binding site 443150010540 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 443150010541 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 443150010542 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 443150010543 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443150010544 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 443150010545 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 443150010546 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443150010547 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 443150010548 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 443150010549 catalytic residues [active] 443150010550 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 443150010551 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 443150010552 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 443150010553 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 443150010554 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 443150010555 active site 443150010556 metal binding site [ion binding]; metal-binding site 443150010557 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 443150010558 ParB-like nuclease domain; Region: ParB; smart00470 443150010559 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 443150010560 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 443150010561 P-loop; other site 443150010562 Magnesium ion binding site [ion binding]; other site 443150010563 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 443150010564 Magnesium ion binding site [ion binding]; other site 443150010565 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 443150010566 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 443150010567 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 443150010568 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 443150010569 G-X-X-G motif; other site 443150010570 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 443150010571 RxxxH motif; other site 443150010572 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449