-- dump date 20140619_154305 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1310115000001 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1310115000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1310115000003 Walker A motif; other site 1310115000004 ATP binding site [chemical binding]; other site 1310115000005 Walker B motif; other site 1310115000006 arginine finger; other site 1310115000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1310115000008 DnaA box-binding interface [nucleotide binding]; other site 1310115000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 1310115000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1310115000011 putative DNA binding surface [nucleotide binding]; other site 1310115000012 dimer interface [polypeptide binding]; other site 1310115000013 beta-clamp/clamp loader binding surface; other site 1310115000014 beta-clamp/translesion DNA polymerase binding surface; other site 1310115000015 recF protein; Region: recf; TIGR00611 1310115000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1310115000017 Walker A/P-loop; other site 1310115000018 ATP binding site [chemical binding]; other site 1310115000019 Q-loop/lid; other site 1310115000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1310115000021 ABC transporter signature motif; other site 1310115000022 Walker B; other site 1310115000023 D-loop; other site 1310115000024 H-loop/switch region; other site 1310115000025 Protein of unknown function (DUF721); Region: DUF721; cl02324 1310115000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1310115000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1310115000028 Mg2+ binding site [ion binding]; other site 1310115000029 G-X-G motif; other site 1310115000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1310115000031 anchoring element; other site 1310115000032 dimer interface [polypeptide binding]; other site 1310115000033 ATP binding site [chemical binding]; other site 1310115000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1310115000035 active site 1310115000036 putative metal-binding site [ion binding]; other site 1310115000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1310115000038 DNA gyrase subunit A; Validated; Region: PRK05560 1310115000039 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1310115000040 CAP-like domain; other site 1310115000041 active site 1310115000042 primary dimer interface [polypeptide binding]; other site 1310115000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1310115000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1310115000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1310115000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1310115000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1310115000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1310115000049 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 1310115000050 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 1310115000051 Protein of unknown function (DUF2562); Region: DUF2562; pfam10814 1310115000052 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1310115000053 active site 1310115000054 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1310115000055 putative septation inhibitor protein; Reviewed; Region: PRK00159 1310115000056 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1310115000057 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1310115000058 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1310115000059 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1310115000060 glutamine binding [chemical binding]; other site 1310115000061 catalytic triad [active] 1310115000062 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1310115000063 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1310115000064 active site 1310115000065 ATP binding site [chemical binding]; other site 1310115000066 substrate binding site [chemical binding]; other site 1310115000067 activation loop (A-loop); other site 1310115000068 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1310115000069 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1310115000070 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1310115000071 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1310115000072 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1310115000073 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1310115000074 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1310115000075 substrate binding site [chemical binding]; other site 1310115000076 activation loop (A-loop); other site 1310115000077 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1310115000078 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1310115000079 active site 1310115000080 ATP binding site [chemical binding]; other site 1310115000081 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1310115000082 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1310115000083 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1310115000084 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1310115000085 active site 1310115000086 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1310115000087 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1310115000088 phosphopeptide binding site; other site 1310115000089 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 1310115000090 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1310115000091 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1310115000092 phosphopeptide binding site; other site 1310115000093 Nitronate monooxygenase; Region: NMO; pfam03060 1310115000094 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1310115000095 FMN binding site [chemical binding]; other site 1310115000096 substrate binding site [chemical binding]; other site 1310115000097 putative catalytic residue [active] 1310115000098 Transcription factor WhiB; Region: Whib; pfam02467 1310115000099 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1310115000100 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1310115000101 non-specific DNA binding site [nucleotide binding]; other site 1310115000102 salt bridge; other site 1310115000103 sequence-specific DNA binding site [nucleotide binding]; other site 1310115000104 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1310115000105 NlpC/P60 family; Region: NLPC_P60; pfam00877 1310115000106 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 1310115000107 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 1310115000108 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 1310115000109 Protein of unknown function (DUF2694); Region: DUF2694; pfam10904 1310115000110 Protein of unknown function (DUF2710); Region: DUF2710; pfam10921 1310115000111 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1310115000112 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 1310115000113 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1310115000114 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1310115000115 catalytic residue [active] 1310115000116 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1310115000117 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 1310115000118 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1310115000119 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1310115000120 acyl-activating enzyme (AAE) consensus motif; other site 1310115000121 active site 1310115000122 TIGR03084 family protein; Region: TIGR03084 1310115000123 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1310115000124 Wyosine base formation; Region: Wyosine_form; pfam08608 1310115000125 H+ Antiporter protein; Region: 2A0121; TIGR00900 1310115000126 hypothetical protein; Validated; Region: PRK00228 1310115000127 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 1310115000128 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1310115000129 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1310115000130 active site 1310115000131 HIGH motif; other site 1310115000132 nucleotide binding site [chemical binding]; other site 1310115000133 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1310115000134 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1310115000135 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1310115000136 active site 1310115000137 KMSKS motif; other site 1310115000138 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1310115000139 tRNA binding surface [nucleotide binding]; other site 1310115000140 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1310115000141 MarR family; Region: MarR; pfam01047 1310115000142 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1310115000143 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1310115000144 DNA-binding site [nucleotide binding]; DNA binding site 1310115000145 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 1310115000146 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1310115000147 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1310115000148 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 1310115000149 inositol 1-phosphate synthase, Actinobacterial type; Region: mycothiol_INO1; TIGR03450 1310115000150 Predicted transcriptional regulators [Transcription]; Region: COG1695 1310115000151 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1310115000152 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 1310115000153 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1310115000154 Transglycosylase; Region: Transgly; pfam00912 1310115000155 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1310115000156 Predicted integral membrane protein [Function unknown]; Region: COG5650 1310115000157 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1310115000158 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1310115000159 conserved cys residue [active] 1310115000160 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1310115000161 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1310115000162 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1310115000163 dimer interface [polypeptide binding]; other site 1310115000164 ssDNA binding site [nucleotide binding]; other site 1310115000165 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1310115000166 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1310115000167 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1310115000168 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1310115000169 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1310115000170 replicative DNA helicase; Validated; Region: PRK07773 1310115000171 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1310115000172 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1310115000173 Walker A motif; other site 1310115000174 ATP binding site [chemical binding]; other site 1310115000175 Walker B motif; other site 1310115000176 DNA binding loops [nucleotide binding] 1310115000177 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1310115000178 protein-splicing catalytic site; other site 1310115000179 thioester formation/cholesterol transfer; other site 1310115000180 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1310115000181 protein-splicing catalytic site; other site 1310115000182 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1310115000183 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 1310115000184 ADP-ribose binding site [chemical binding]; other site 1310115000185 Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1 [General function prediction only]; Region: COG2110 1310115000186 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 1310115000187 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1310115000188 FAD binding domain; Region: FAD_binding_4; pfam01565 1310115000189 Berberine and berberine like; Region: BBE; pfam08031 1310115000190 hypothetical protein; Provisional; Region: PRK12438 1310115000191 hypothetical protein; Validated; Region: PRK00068 1310115000192 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1310115000193 homotetrameric interface [polypeptide binding]; other site 1310115000194 putative active site [active] 1310115000195 metal binding site [ion binding]; metal-binding site 1310115000196 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 1310115000197 Monomeric isocitrate dehydrogenase; Region: IDH; pfam03971 1310115000198 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310115000199 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310115000200 short chain dehydrogenase; Provisional; Region: PRK06197 1310115000201 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1310115000202 putative NAD(P) binding site [chemical binding]; other site 1310115000203 active site 1310115000204 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1310115000205 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1310115000206 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1310115000207 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1310115000208 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1310115000209 catalytic residue [active] 1310115000210 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1310115000211 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1310115000212 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 1310115000213 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1310115000214 putative NTP binding site [chemical binding]; other site 1310115000215 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1310115000216 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1310115000217 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1310115000218 Walker A/P-loop; other site 1310115000219 ATP binding site [chemical binding]; other site 1310115000220 Q-loop/lid; other site 1310115000221 ABC transporter signature motif; other site 1310115000222 Walker B; other site 1310115000223 D-loop; other site 1310115000224 H-loop/switch region; other site 1310115000225 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1310115000226 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1310115000227 ligand binding site [chemical binding]; other site 1310115000228 flexible hinge region; other site 1310115000229 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1310115000230 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1310115000231 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1310115000232 active site 1310115000233 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1310115000234 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1310115000235 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310115000236 homodimer interface [polypeptide binding]; other site 1310115000237 catalytic residue [active] 1310115000238 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1310115000239 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310115000240 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310115000241 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1310115000242 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1310115000243 dimerization interface [polypeptide binding]; other site 1310115000244 putative DNA binding site [nucleotide binding]; other site 1310115000245 putative Zn2+ binding site [ion binding]; other site 1310115000246 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 1310115000247 hydrogenase 4 subunit B; Validated; Region: PRK06521 1310115000248 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1310115000249 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1310115000250 NADH dehydrogenase; Region: NADHdh; cl00469 1310115000251 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; COG4237 1310115000252 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1310115000253 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 1310115000254 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 1310115000255 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 1310115000256 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 1310115000257 putative hydrophobic ligand binding site [chemical binding]; other site 1310115000258 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310115000259 S-adenosylmethionine binding site [chemical binding]; other site 1310115000260 Predicted membrane protein [Function unknown]; Region: COG3305 1310115000261 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1310115000262 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1310115000263 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1310115000264 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1310115000265 metal-binding site [ion binding] 1310115000266 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1310115000267 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1310115000268 Predicted integral membrane protein [Function unknown]; Region: COG5660 1310115000269 Putative zinc-finger; Region: zf-HC2; pfam13490 1310115000270 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1310115000271 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1310115000272 active site 1310115000273 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1310115000274 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115000275 PPE family; Region: PPE; pfam00823 1310115000276 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1310115000277 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 1310115000278 FcoT-like thioesterase domain; Region: FcoT; pfam10862 1310115000279 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1310115000280 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1310115000281 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 1310115000282 acyl-activating enzyme (AAE) consensus motif; other site 1310115000283 acyl-activating enzyme (AAE) consensus motif; other site 1310115000284 active site 1310115000285 AMP binding site [chemical binding]; other site 1310115000286 CoA binding site [chemical binding]; other site 1310115000287 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1310115000288 AMP-binding enzyme; Region: AMP-binding; pfam00501 1310115000289 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1310115000290 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1310115000291 acyl-activating enzyme (AAE) consensus motif; other site 1310115000292 acyl-activating enzyme (AAE) consensus motif; other site 1310115000293 active site 1310115000294 AMP binding site [chemical binding]; other site 1310115000295 CoA binding site [chemical binding]; other site 1310115000296 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1310115000297 Condensation domain; Region: Condensation; pfam00668 1310115000298 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1310115000299 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1310115000300 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1310115000301 acyl-activating enzyme (AAE) consensus motif; other site 1310115000302 AMP binding site [chemical binding]; other site 1310115000303 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1310115000304 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 1310115000305 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1310115000306 putative NAD(P) binding site [chemical binding]; other site 1310115000307 active site 1310115000308 putative substrate binding site [chemical binding]; other site 1310115000309 Predicted membrane protein [Function unknown]; Region: COG3336 1310115000310 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1310115000311 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1310115000312 metal-binding site [ion binding] 1310115000313 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1310115000314 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1310115000315 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1310115000316 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1310115000317 ligand binding site [chemical binding]; other site 1310115000318 flexible hinge region; other site 1310115000319 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1310115000320 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1310115000321 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1310115000322 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1310115000323 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1310115000324 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1310115000325 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1310115000326 motif II; other site 1310115000327 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1310115000328 PE family; Region: PE; pfam00934 1310115000329 Rhomboid family; Region: Rhomboid; pfam01694 1310115000330 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1310115000331 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1310115000332 active site 1310115000333 catalytic triad [active] 1310115000334 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1310115000335 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1310115000336 NADP-binding site; other site 1310115000337 homotetramer interface [polypeptide binding]; other site 1310115000338 substrate binding site [chemical binding]; other site 1310115000339 homodimer interface [polypeptide binding]; other site 1310115000340 active site 1310115000341 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1310115000342 dimer interface [polypeptide binding]; other site 1310115000343 active site 1310115000344 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 1310115000345 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1310115000346 active site 1310115000347 motif I; other site 1310115000348 motif II; other site 1310115000349 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 1310115000350 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1310115000351 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1310115000352 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1310115000353 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1310115000354 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1310115000355 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1310115000356 dimerization interface [polypeptide binding]; other site 1310115000357 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 1310115000358 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1310115000359 PYR/PP interface [polypeptide binding]; other site 1310115000360 dimer interface [polypeptide binding]; other site 1310115000361 TPP binding site [chemical binding]; other site 1310115000362 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1310115000363 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 1310115000364 TPP-binding site; other site 1310115000365 dimer interface [polypeptide binding]; other site 1310115000366 acyl-CoA synthetase; Validated; Region: PRK05852 1310115000367 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1310115000368 Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926 1310115000369 acyl-activating enzyme (AAE) consensus motif; other site 1310115000370 acyl-activating enzyme (AAE) consensus motif; other site 1310115000371 putative AMP binding site [chemical binding]; other site 1310115000372 putative active site [active] 1310115000373 putative CoA binding site [chemical binding]; other site 1310115000374 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 1310115000375 elongation factor G; Reviewed; Region: PRK12740 1310115000376 G1 box; other site 1310115000377 putative GEF interaction site [polypeptide binding]; other site 1310115000378 GTP/Mg2+ binding site [chemical binding]; other site 1310115000379 Switch I region; other site 1310115000380 G2 box; other site 1310115000381 G3 box; other site 1310115000382 Switch II region; other site 1310115000383 G4 box; other site 1310115000384 G5 box; other site 1310115000385 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1310115000386 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1310115000387 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1310115000388 PPOX class probable F420-dependent enzyme, Rv0121 family; Region: Rv0121_F420; TIGR03668 1310115000389 PE family; Region: PE; pfam00934 1310115000390 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1310115000391 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1310115000392 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1310115000393 trehalose synthase; Region: treS_nterm; TIGR02456 1310115000394 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 1310115000395 active site 1310115000396 catalytic site [active] 1310115000397 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 1310115000398 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 1310115000399 Predicted membrane protein [Function unknown]; Region: COG3619 1310115000400 Predicted esterase [General function prediction only]; Region: COG0627 1310115000401 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 1310115000402 putative active site [active] 1310115000403 putative catalytic site [active] 1310115000404 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1310115000405 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1310115000406 active site 1310115000407 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 1310115000408 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1310115000409 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1310115000410 Coenzyme A binding pocket [chemical binding]; other site 1310115000411 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1310115000412 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1310115000413 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310115000414 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310115000415 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1310115000416 Cytochrome P450; Region: p450; cl12078 1310115000417 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1310115000418 SnoaL-like domain; Region: SnoaL_2; pfam12680 1310115000419 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1310115000420 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310115000421 NAD(P) binding site [chemical binding]; other site 1310115000422 active site 1310115000423 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 1310115000424 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 1310115000425 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1310115000426 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1310115000427 minor groove reading motif; other site 1310115000428 helix-hairpin-helix signature motif; other site 1310115000429 active site 1310115000430 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1310115000431 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1310115000432 Cl- selectivity filter; other site 1310115000433 Cl- binding residues [ion binding]; other site 1310115000434 pore gating glutamate residue; other site 1310115000435 dimer interface [polypeptide binding]; other site 1310115000436 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310115000437 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1310115000438 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1310115000439 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1310115000440 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1310115000441 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 1310115000442 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 1310115000443 NAD(P) binding site [chemical binding]; other site 1310115000444 catalytic residues [active] 1310115000445 short chain dehydrogenase; Provisional; Region: PRK07791 1310115000446 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 1310115000447 NAD binding site [chemical binding]; other site 1310115000448 homodimer interface [polypeptide binding]; other site 1310115000449 active site 1310115000450 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1310115000451 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 1310115000452 NAD(P) binding site [chemical binding]; other site 1310115000453 PE family; Region: PE; pfam00934 1310115000454 PE-PPE domain; Region: PE-PPE; pfam08237 1310115000455 PE-PPE domain; Region: PE-PPE; pfam08237 1310115000456 PE family; Region: PE; pfam00934 1310115000457 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 1310115000458 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1310115000459 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1310115000460 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 1310115000461 FAD binding site [chemical binding]; other site 1310115000462 substrate binding site [chemical binding]; other site 1310115000463 catalytic base [active] 1310115000464 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 1310115000465 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1310115000466 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1310115000467 ligand binding site [chemical binding]; other site 1310115000468 homodimer interface [polypeptide binding]; other site 1310115000469 NAD(P) binding site [chemical binding]; other site 1310115000470 trimer interface B [polypeptide binding]; other site 1310115000471 trimer interface A [polypeptide binding]; other site 1310115000472 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1310115000473 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1310115000474 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 1310115000475 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1310115000476 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310115000477 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310115000478 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 1310115000479 PE family; Region: PE; pfam00934 1310115000480 PE-PPE domain; Region: PE-PPE; pfam08237 1310115000481 PE family; Region: PE; pfam00934 1310115000482 PE-PPE domain; Region: PE-PPE; pfam08237 1310115000483 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1310115000484 FAD binding domain; Region: FAD_binding_4; pfam01565 1310115000485 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1310115000486 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1310115000487 NAD(P) binding site [chemical binding]; other site 1310115000488 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1310115000489 active site 1310115000490 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1310115000491 putative hydrophobic ligand binding site [chemical binding]; other site 1310115000492 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1310115000493 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1310115000494 DNA-binding site [nucleotide binding]; DNA binding site 1310115000495 FCD domain; Region: FCD; pfam07729 1310115000496 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786 1310115000497 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1310115000498 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1310115000499 acyl-activating enzyme (AAE) consensus motif; other site 1310115000500 acyl-activating enzyme (AAE) consensus motif; other site 1310115000501 putative AMP binding site [chemical binding]; other site 1310115000502 putative active site [active] 1310115000503 putative CoA binding site [chemical binding]; other site 1310115000504 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1310115000505 Permease; Region: Permease; pfam02405 1310115000506 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1310115000507 Permease; Region: Permease; pfam02405 1310115000508 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1310115000509 mce related protein; Region: MCE; pfam02470 1310115000510 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1310115000511 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1310115000512 mce related protein; Region: MCE; pfam02470 1310115000513 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1310115000514 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1310115000515 mce related protein; Region: MCE; pfam02470 1310115000516 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1310115000517 mce related protein; Region: MCE; pfam02470 1310115000518 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1310115000519 mce related protein; Region: MCE; pfam02470 1310115000520 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1310115000521 mce related protein; Region: MCE; pfam02470 1310115000522 RDD family; Region: RDD; pfam06271 1310115000523 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1310115000524 Predicted membrane protein [Function unknown]; Region: COG1511 1310115000525 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1310115000526 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1310115000527 Pirin-related protein [General function prediction only]; Region: COG1741 1310115000528 Pirin; Region: Pirin; pfam02678 1310115000529 RNA polymerase factor sigma-70; Validated; Region: PRK08241 1310115000530 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1310115000531 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1310115000532 DNA binding residues [nucleotide binding] 1310115000533 SnoaL-like domain; Region: SnoaL_2; pfam12680 1310115000534 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1310115000535 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1310115000536 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 1310115000537 putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185 1310115000538 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1310115000539 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1310115000540 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1310115000541 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1310115000542 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1310115000543 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310115000544 S-adenosylmethionine binding site [chemical binding]; other site 1310115000545 SPW repeat; Region: SPW; pfam03779 1310115000546 SPW repeat; Region: SPW; pfam03779 1310115000547 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1310115000548 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1310115000549 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1310115000550 putative homodimer interface [polypeptide binding]; other site 1310115000551 putative homotetramer interface [polypeptide binding]; other site 1310115000552 putative allosteric switch controlling residues; other site 1310115000553 putative metal binding site [ion binding]; other site 1310115000554 putative homodimer-homodimer interface [polypeptide binding]; other site 1310115000555 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1310115000556 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310115000557 putative substrate translocation pore; other site 1310115000558 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1310115000559 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1310115000560 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1310115000561 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1310115000562 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1310115000563 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1310115000564 Walker A/P-loop; other site 1310115000565 ATP binding site [chemical binding]; other site 1310115000566 Q-loop/lid; other site 1310115000567 ABC transporter signature motif; other site 1310115000568 Walker B; other site 1310115000569 D-loop; other site 1310115000570 H-loop/switch region; other site 1310115000571 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1310115000572 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1310115000573 Walker A/P-loop; other site 1310115000574 ATP binding site [chemical binding]; other site 1310115000575 Q-loop/lid; other site 1310115000576 ABC transporter signature motif; other site 1310115000577 Walker B; other site 1310115000578 D-loop; other site 1310115000579 H-loop/switch region; other site 1310115000580 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1310115000581 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1310115000582 dimerization interface [polypeptide binding]; other site 1310115000583 DNA binding residues [nucleotide binding] 1310115000584 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310115000585 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310115000586 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1310115000587 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 1310115000588 putative [Fe4-S4] binding site [ion binding]; other site 1310115000589 putative molybdopterin cofactor binding site [chemical binding]; other site 1310115000590 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1310115000591 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 1310115000592 putative molybdopterin cofactor binding site; other site 1310115000593 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1310115000594 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1310115000595 active site 1310115000596 Zn binding site [ion binding]; other site 1310115000597 potential frameshift: common BLAST hit: gi|471336010|ref|YP_007608723.1| transmembrane transport protein 1310115000598 Predicted integral membrane protein [Function unknown]; Region: COG0392 1310115000599 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1310115000600 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1310115000601 MMPL family; Region: MMPL; pfam03176 1310115000602 MMPL family; Region: MMPL; pfam03176 1310115000603 LabA_like proteins; Region: LabA_like; cd06167 1310115000604 putative metal binding site [ion binding]; other site 1310115000605 Putative methyltransferase; Region: Methyltransf_4; pfam02390 1310115000606 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 1310115000607 active site 1310115000608 substrate-binding site [chemical binding]; other site 1310115000609 metal-binding site [ion binding] 1310115000610 GTP binding site [chemical binding]; other site 1310115000611 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 1310115000612 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 1310115000613 active site 1310115000614 (T/H)XGH motif; other site 1310115000615 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 1310115000616 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 1310115000617 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 1310115000618 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1310115000619 FeS/SAM binding site; other site 1310115000620 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 1310115000621 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1310115000622 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1310115000623 acyl-activating enzyme (AAE) consensus motif; other site 1310115000624 acyl-activating enzyme (AAE) consensus motif; other site 1310115000625 putative AMP binding site [chemical binding]; other site 1310115000626 putative active site [active] 1310115000627 putative CoA binding site [chemical binding]; other site 1310115000628 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1310115000629 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1310115000630 active site 1310115000631 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 1310115000632 putative active site [active] 1310115000633 putative catalytic site [active] 1310115000634 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1310115000635 active site 2 [active] 1310115000636 active site 1 [active] 1310115000637 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1310115000638 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1310115000639 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1310115000640 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321 1310115000641 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1310115000642 Moco binding site; other site 1310115000643 metal coordination site [ion binding]; other site 1310115000644 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1310115000645 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1310115000646 potential frameshift: common BLAST hit: gi|433625323|ref|YP_007258952.1| Putative triacylglycerol synthase (diacylglycerol acyltransferase) 1310115000647 enoyl-CoA hydratase; Provisional; Region: PRK08252 1310115000648 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1310115000649 substrate binding site [chemical binding]; other site 1310115000650 oxyanion hole (OAH) forming residues; other site 1310115000651 trimer interface [polypeptide binding]; other site 1310115000652 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 1310115000653 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1310115000654 NAD binding site [chemical binding]; other site 1310115000655 catalytic residues [active] 1310115000656 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310115000657 S-adenosylmethionine binding site [chemical binding]; other site 1310115000658 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1310115000659 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1310115000660 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 1310115000661 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1310115000662 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1310115000663 putative active site [active] 1310115000664 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 1310115000665 active site 1310115000666 substrate binding pocket [chemical binding]; other site 1310115000667 homodimer interaction site [polypeptide binding]; other site 1310115000668 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1310115000669 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1310115000670 active site 1310115000671 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310115000672 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310115000673 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 1310115000674 active site 1310115000675 diiron metal binding site [ion binding]; other site 1310115000676 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1310115000677 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1310115000678 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1310115000679 NAD(P) binding site [chemical binding]; other site 1310115000680 catalytic residues [active] 1310115000681 Lipase maturation factor; Region: LMF1; pfam06762 1310115000682 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 1310115000683 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 1310115000684 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1310115000685 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1310115000686 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310115000687 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310115000688 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1310115000689 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1310115000690 MaoC like domain; Region: MaoC_dehydratas; pfam01575 1310115000691 active site 2 [active] 1310115000692 active site 1 [active] 1310115000693 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 1310115000694 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310115000695 NAD(P) binding site [chemical binding]; other site 1310115000696 active site 1310115000697 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 1310115000698 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1310115000699 dimer interface [polypeptide binding]; other site 1310115000700 active site 1310115000701 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1310115000702 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1310115000703 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 1310115000704 FAD binding site [chemical binding]; other site 1310115000705 substrate binding site [chemical binding]; other site 1310115000706 catalytic residues [active] 1310115000707 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1310115000708 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1310115000709 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 1310115000710 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1310115000711 catalytic loop [active] 1310115000712 iron binding site [ion binding]; other site 1310115000713 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 1310115000714 L-aspartate oxidase; Provisional; Region: PRK06175 1310115000715 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1310115000716 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1310115000717 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1310115000718 putative dimer interface [polypeptide binding]; other site 1310115000719 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 1310115000720 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1310115000721 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1310115000722 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1310115000723 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 1310115000724 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1310115000725 homotrimer interface [polypeptide binding]; other site 1310115000726 Walker A motif; other site 1310115000727 GTP binding site [chemical binding]; other site 1310115000728 Walker B motif; other site 1310115000729 cobyric acid synthase; Provisional; Region: PRK00784 1310115000730 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 1310115000731 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1310115000732 catalytic triad [active] 1310115000733 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115000734 PPE family; Region: PPE; pfam00823 1310115000735 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1310115000736 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1310115000737 putative active site [active] 1310115000738 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1310115000739 putative active site [active] 1310115000740 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 1310115000741 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1310115000742 active site 1310115000743 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 1310115000744 DNA binding site [nucleotide binding] 1310115000745 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1310115000746 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1310115000747 Coenzyme A binding pocket [chemical binding]; other site 1310115000748 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 1310115000749 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1310115000750 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 1310115000751 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1310115000752 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1310115000753 intersubunit interface [polypeptide binding]; other site 1310115000754 5-oxoprolinase; Region: PLN02666 1310115000755 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 1310115000756 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 1310115000757 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 1310115000758 potential frameshift: common BLAST hit: gi|471336076|ref|YP_007608789.1| integral membrane nitrite extrusion protein 1310115000759 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 1310115000760 potential frameshift: common BLAST hit: gi|397672058|ref|YP_006513593.1| DNA polymerase LigD, polymerase domain-containing protein 1310115000761 acyl-CoA synthetase; Validated; Region: PRK07788 1310115000762 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1310115000763 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1310115000764 active site 1310115000765 CoA binding site [chemical binding]; other site 1310115000766 AMP binding site [chemical binding]; other site 1310115000767 potential frameshift: common BLAST hit: gi|471336081|ref|YP_007608794.1| acyl-CoA dehydrogenase 1310115000768 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1310115000769 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310115000770 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310115000771 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1310115000772 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1310115000773 Zn binding site [ion binding]; other site 1310115000774 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 1310115000775 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1310115000776 putative active site [active] 1310115000777 PE family; Region: PE; pfam00934 1310115000778 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115000779 PPE family; Region: PPE; pfam00823 1310115000780 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115000781 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1310115000782 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1310115000783 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1310115000784 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1310115000785 Walker A motif; other site 1310115000786 ATP binding site [chemical binding]; other site 1310115000787 Walker B motif; other site 1310115000788 arginine finger; other site 1310115000789 potential frameshift: common BLAST hit: gi|433640419|ref|YP_007286178.1| ESX conserved componant EccB3 1310115000790 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1310115000791 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1310115000792 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1310115000793 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1310115000794 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1310115000795 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115000796 PPE family; Region: PPE; pfam00823 1310115000797 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1310115000798 EspG family; Region: ESX-1_EspG; pfam14011 1310115000799 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1310115000800 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1310115000801 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1310115000802 active site 1310115000803 catalytic residues [active] 1310115000804 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1310115000805 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1310115000806 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 1310115000807 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 1310115000808 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310115000809 S-adenosylmethionine binding site [chemical binding]; other site 1310115000810 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4424 1310115000811 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1310115000812 Sulfatase; Region: Sulfatase; cl17466 1310115000813 hypothetical protein; Region: PHA01748 1310115000814 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1310115000815 putative active site [active] 1310115000816 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310115000817 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310115000818 light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs; Region: LPOR_like_SDR_c_like; cd09810 1310115000819 protochlorophyllide reductase; Region: PLN00015 1310115000820 putative NAD(P) binding site [chemical binding]; other site 1310115000821 active site 1310115000822 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115000823 PPE family; Region: PPE; pfam00823 1310115000824 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115000825 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310115000826 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115000827 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310115000828 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310115000829 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115000830 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310115000831 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310115000832 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115000833 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310115000834 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310115000835 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310115000836 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 1310115000837 putative FMN binding site [chemical binding]; other site 1310115000838 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1310115000839 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1310115000840 active site 1310115000841 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 1310115000842 SnoaL-like domain; Region: SnoaL_4; pfam13577 1310115000843 SnoaL-like domain; Region: SnoaL_3; pfam13474 1310115000844 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 1310115000845 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1310115000846 nucleotide binding site [chemical binding]; other site 1310115000847 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]; Region: HtpG; COG0326 1310115000848 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 1310115000849 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 1310115000850 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 1310115000851 active site 1310115000852 catalytic residues [active] 1310115000853 Muconolactone delta-isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CatC1; COG4829 1310115000854 Muconolactone delta-isomerase; Region: MIase; cl01992 1310115000855 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 1310115000856 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1310115000857 putative active site [active] 1310115000858 catalytic site [active] 1310115000859 putative metal binding site [ion binding]; other site 1310115000860 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 1310115000861 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1310115000862 putative substrate binding pocket [chemical binding]; other site 1310115000863 AC domain interface; other site 1310115000864 catalytic triad [active] 1310115000865 AB domain interface; other site 1310115000866 interchain disulfide; other site 1310115000867 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1310115000868 trimer interface [polypeptide binding]; other site 1310115000869 active site 1310115000870 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1310115000871 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1310115000872 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1310115000873 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1310115000874 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 1310115000875 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1310115000876 dimerization interface [polypeptide binding]; other site 1310115000877 putative DNA binding site [nucleotide binding]; other site 1310115000878 putative Zn2+ binding site [ion binding]; other site 1310115000879 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1310115000880 active site residue [active] 1310115000881 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310115000882 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1310115000883 Cytochrome P450; Region: p450; cl12078 1310115000884 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1310115000885 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310115000886 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1310115000887 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310115000888 S-adenosylmethionine binding site [chemical binding]; other site 1310115000889 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310115000890 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310115000891 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1310115000892 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1310115000893 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1310115000894 SnoaL-like domain; Region: SnoaL_2; pfam12680 1310115000895 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1310115000896 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1310115000897 substrate binding site; other site 1310115000898 tetramer interface; other site 1310115000899 PE family; Region: PE; pfam00934 1310115000900 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1310115000901 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1310115000902 active site 1310115000903 aminotransferase AlaT; Validated; Region: PRK09265 1310115000904 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1310115000905 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310115000906 homodimer interface [polypeptide binding]; other site 1310115000907 catalytic residue [active] 1310115000908 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1310115000909 4Fe-4S binding domain; Region: Fer4; pfam00037 1310115000910 Cysteine-rich domain; Region: CCG; pfam02754 1310115000911 Cysteine-rich domain; Region: CCG; pfam02754 1310115000912 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1310115000913 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1310115000914 DNA binding residues [nucleotide binding] 1310115000915 dimerization interface [polypeptide binding]; other site 1310115000916 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 1310115000917 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1310115000918 G1 box; other site 1310115000919 GTP/Mg2+ binding site [chemical binding]; other site 1310115000920 G2 box; other site 1310115000921 Switch I region; other site 1310115000922 G3 box; other site 1310115000923 Switch II region; other site 1310115000924 G4 box; other site 1310115000925 G5 box; other site 1310115000926 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 1310115000927 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1310115000928 G1 box; other site 1310115000929 GTP/Mg2+ binding site [chemical binding]; other site 1310115000930 G2 box; other site 1310115000931 Switch I region; other site 1310115000932 G3 box; other site 1310115000933 Switch II region; other site 1310115000934 Uncharacterized MobA-related protein [General function prediction only]; Region: COG2068 1310115000935 active site 1310115000936 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1310115000937 TIGR04255 family protein; Region: sporadTIGR04255 1310115000938 potential frameshift: common BLAST hit: gi|15839736|ref|NP_334773.1| molecular chaperone DnaK 1310115000939 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 1310115000940 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1310115000941 dimer interface [polypeptide binding]; other site 1310115000942 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1310115000943 chaperone protein DnaJ; Provisional; Region: PRK14279 1310115000944 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1310115000945 HSP70 interaction site [polypeptide binding]; other site 1310115000946 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1310115000947 Zn binding sites [ion binding]; other site 1310115000948 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1310115000949 dimer interface [polypeptide binding]; other site 1310115000950 Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279 1310115000951 DNA binding residues [nucleotide binding] 1310115000952 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1310115000953 putative dimer interface [polypeptide binding]; other site 1310115000954 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115000955 PPE family; Region: PPE; pfam00823 1310115000956 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310115000957 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115000958 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310115000959 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115000960 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310115000961 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115000962 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310115000963 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115000964 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310115000965 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310115000966 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1310115000967 CoenzymeA binding site [chemical binding]; other site 1310115000968 subunit interaction site [polypeptide binding]; other site 1310115000969 PHB binding site; other site 1310115000970 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1310115000971 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1310115000972 GDP-binding site [chemical binding]; other site 1310115000973 ACT binding site; other site 1310115000974 IMP binding site; other site 1310115000975 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1310115000976 Peptidase family M50; Region: Peptidase_M50; pfam02163 1310115000977 active site 1310115000978 putative substrate binding region [chemical binding]; other site 1310115000979 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 1310115000980 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1310115000981 MgtE intracellular N domain; Region: MgtE_N; pfam03448 1310115000982 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1310115000983 Divalent cation transporter; Region: MgtE; pfam01769 1310115000984 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1310115000985 fructose-bisphosphate aldolase, class II, yeast/E. coli subtype; Region: FruBisAldo_II_A; TIGR01520 1310115000986 active site 1310115000987 intersubunit interface [polypeptide binding]; other site 1310115000988 zinc binding site [ion binding]; other site 1310115000989 Na+ binding site [ion binding]; other site 1310115000990 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1310115000991 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1310115000992 Predicted glycosyl hydrolase [Carbohydrate transport and metabolism]; Region: COG4833 1310115000993 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 1310115000994 AAA domain; Region: AAA_33; pfam13671 1310115000995 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 1310115000996 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 1310115000997 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 1310115000998 metal ion-dependent adhesion site (MIDAS); other site 1310115000999 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 1310115001000 putative hydrophobic ligand binding site [chemical binding]; other site 1310115001001 MoxR-like ATPases [General function prediction only]; Region: COG0714 1310115001002 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1310115001003 Ligand binding site; other site 1310115001004 metal-binding site 1310115001005 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1310115001006 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1310115001007 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1310115001008 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 1310115001009 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 1310115001010 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1310115001011 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1310115001012 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1310115001013 catalytic loop [active] 1310115001014 iron binding site [ion binding]; other site 1310115001015 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1310115001016 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1310115001017 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 1310115001018 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1310115001019 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1310115001020 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1310115001021 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1310115001022 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1310115001023 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1310115001024 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1310115001025 dimerization interface [polypeptide binding]; other site 1310115001026 Uncharacterized conserved protein [Function unknown]; Region: COG3360 1310115001027 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1310115001028 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1310115001029 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1310115001030 active site 1310115001031 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1310115001032 Clp amino terminal domain; Region: Clp_N; pfam02861 1310115001033 Clp amino terminal domain; Region: Clp_N; pfam02861 1310115001034 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1310115001035 Walker A motif; other site 1310115001036 ATP binding site [chemical binding]; other site 1310115001037 Walker B motif; other site 1310115001038 arginine finger; other site 1310115001039 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1310115001040 Walker A motif; other site 1310115001041 ATP binding site [chemical binding]; other site 1310115001042 Walker B motif; other site 1310115001043 arginine finger; other site 1310115001044 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1310115001045 potential frameshift: common BLAST hit: gi|392430800|ref|YP_006471844.1| monooxygenase 1310115001046 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1310115001047 cyclase homology domain; Region: CHD; cd07302 1310115001048 nucleotidyl binding site; other site 1310115001049 metal binding site [ion binding]; metal-binding site 1310115001050 dimer interface [polypeptide binding]; other site 1310115001051 Predicted ATPase [General function prediction only]; Region: COG3903 1310115001052 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1310115001053 Walker A motif; other site 1310115001054 ATP binding site [chemical binding]; other site 1310115001055 Walker B motif; other site 1310115001056 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1310115001057 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1310115001058 DNA binding residues [nucleotide binding] 1310115001059 dimerization interface [polypeptide binding]; other site 1310115001060 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115001061 PPE family; Region: PPE; pfam00823 1310115001062 Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase) [Nucleotide transport and metabolism]; Region: PurT; COG0027 1310115001063 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1310115001064 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 1310115001065 active site residue [active] 1310115001066 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 1310115001067 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1310115001068 homodimer interface [polypeptide binding]; other site 1310115001069 substrate-cofactor binding pocket; other site 1310115001070 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310115001071 catalytic residue [active] 1310115001072 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1310115001073 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1310115001074 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1310115001075 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1310115001076 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1310115001077 active site 1310115001078 PLD-like domain; Region: PLDc_2; pfam13091 1310115001079 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1310115001080 Beta-lactamase; Region: Beta-lactamase; pfam00144 1310115001081 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1310115001082 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1310115001083 active site 1310115001084 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 1310115001085 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1310115001086 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1310115001087 acyl-CoA synthetase; Validated; Region: PRK05850 1310115001088 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1310115001089 acyl-activating enzyme (AAE) consensus motif; other site 1310115001090 active site 1310115001091 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1310115001092 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1310115001093 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1310115001094 active site 1310115001095 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1310115001096 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1310115001097 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1310115001098 Thioesterase; Region: PKS_TE; smart00824 1310115001099 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1310115001100 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 1310115001101 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1310115001102 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1310115001103 phosphate acetyltransferase; Reviewed; Region: PRK05632 1310115001104 DRTGG domain; Region: DRTGG; pfam07085 1310115001105 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1310115001106 propionate/acetate kinase; Provisional; Region: PRK12379 1310115001107 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1310115001108 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1310115001109 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1310115001110 active site 1310115001111 ATP binding site [chemical binding]; other site 1310115001112 substrate binding site [chemical binding]; other site 1310115001113 activation loop (A-loop); other site 1310115001114 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1310115001115 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1310115001116 substrate binding pocket [chemical binding]; other site 1310115001117 membrane-bound complex binding site; other site 1310115001118 hinge residues; other site 1310115001119 NUDIX domain; Region: NUDIX; pfam00293 1310115001120 nudix motif; other site 1310115001121 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1310115001122 thiamine phosphate binding site [chemical binding]; other site 1310115001123 active site 1310115001124 pyrophosphate binding site [ion binding]; other site 1310115001125 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1310115001126 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1310115001127 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1310115001128 thiS-thiF/thiG interaction site; other site 1310115001129 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1310115001130 ThiS interaction site; other site 1310115001131 putative active site [active] 1310115001132 tetramer interface [polypeptide binding]; other site 1310115001133 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 1310115001134 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1310115001135 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 1310115001136 PA/protease or protease-like domain interface [polypeptide binding]; other site 1310115001137 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 1310115001138 active site 1310115001139 metal binding site [ion binding]; metal-binding site 1310115001140 Predicted metalloprotease [General function prediction only]; Region: COG2321 1310115001141 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1310115001142 Zn binding site [ion binding]; other site 1310115001143 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1310115001144 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1310115001145 dimer interface [polypeptide binding]; other site 1310115001146 substrate binding site [chemical binding]; other site 1310115001147 ATP binding site [chemical binding]; other site 1310115001148 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1310115001149 ThiC-associated domain; Region: ThiC-associated; pfam13667 1310115001150 ThiC family; Region: ThiC; pfam01964 1310115001151 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1310115001152 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 1310115001153 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1310115001154 motif II; other site 1310115001155 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1310115001156 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1310115001157 putative catalytic site [active] 1310115001158 putative phosphate binding site [ion binding]; other site 1310115001159 active site 1310115001160 metal binding site A [ion binding]; metal-binding site 1310115001161 DNA binding site [nucleotide binding] 1310115001162 putative AP binding site [nucleotide binding]; other site 1310115001163 putative metal binding site B [ion binding]; other site 1310115001164 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1310115001165 active site 1310115001166 catalytic residues [active] 1310115001167 metal binding site [ion binding]; metal-binding site 1310115001168 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 1310115001169 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1310115001170 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1310115001171 E-class dimer interface [polypeptide binding]; other site 1310115001172 P-class dimer interface [polypeptide binding]; other site 1310115001173 active site 1310115001174 Cu2+ binding site [ion binding]; other site 1310115001175 Zn2+ binding site [ion binding]; other site 1310115001176 carboxylate-amine ligase; Provisional; Region: PRK13517 1310115001177 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1310115001178 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 1310115001179 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 1310115001180 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 1310115001181 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1310115001182 Walker A motif; other site 1310115001183 ATP binding site [chemical binding]; other site 1310115001184 Walker B motif; other site 1310115001185 arginine finger; other site 1310115001186 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1310115001187 Walker A motif; other site 1310115001188 ATP binding site [chemical binding]; other site 1310115001189 Walker B motif; other site 1310115001190 arginine finger; other site 1310115001191 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1310115001192 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1310115001193 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 1310115001194 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1310115001195 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1310115001196 dimer interface [polypeptide binding]; other site 1310115001197 putative functional site; other site 1310115001198 putative MPT binding site; other site 1310115001199 short chain dehydrogenase; Provisional; Region: PRK06197 1310115001200 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1310115001201 putative NAD(P) binding site [chemical binding]; other site 1310115001202 active site 1310115001203 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1310115001204 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1310115001205 ring oligomerisation interface [polypeptide binding]; other site 1310115001206 ATP/Mg binding site [chemical binding]; other site 1310115001207 stacking interactions; other site 1310115001208 hinge regions; other site 1310115001209 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115001210 PPE family; Region: PPE; pfam00823 1310115001211 putative anti-sigmaE protein; Provisional; Region: PRK13920 1310115001212 Anti-sigma-K factor rskA; Region: RskA; pfam10099 1310115001213 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 1310115001214 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1310115001215 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1310115001216 DNA binding residues [nucleotide binding] 1310115001217 Steroid 5-alpha reductase family enzyme [General function prediction only]; Region: COG3752 1310115001218 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1310115001219 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310115001220 S-adenosylmethionine binding site [chemical binding]; other site 1310115001221 Uncharacterized conserved protein [Function unknown]; Region: COG3496 1310115001222 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 1310115001223 Subunit A of Class III extradiol dioxygenases; Region: Extradiol_Dioxygenase_3A_like; cl06673 1310115001224 dimer interface [polypeptide binding]; other site 1310115001225 Transport protein; Region: actII; TIGR00833 1310115001226 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1310115001227 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310115001228 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115001229 PPE family; Region: PPE; pfam00823 1310115001230 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115001231 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 1310115001232 enoyl-CoA hydratase; Provisional; Region: PRK12478 1310115001233 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1310115001234 substrate binding site [chemical binding]; other site 1310115001235 oxyanion hole (OAH) forming residues; other site 1310115001236 trimer interface [polypeptide binding]; other site 1310115001237 PemK-like protein; Region: PemK; pfam02452 1310115001238 potential frameshift: common BLAST hit: gi|449062458|ref|YP_007429541.1| peptidase 1310115001239 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 1310115001240 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1310115001241 NAD(P) binding site [chemical binding]; other site 1310115001242 catalytic residues [active] 1310115001243 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3564 1310115001244 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 1310115001245 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1310115001246 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1310115001247 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1310115001248 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1310115001249 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1310115001250 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1310115001251 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1310115001252 non-specific DNA binding site [nucleotide binding]; other site 1310115001253 salt bridge; other site 1310115001254 sequence-specific DNA binding site [nucleotide binding]; other site 1310115001255 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1310115001256 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1310115001257 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1310115001258 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 1310115001259 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1310115001260 active site 1310115001261 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1310115001262 active site 2 [active] 1310115001263 isocitrate lyase; Provisional; Region: PRK15063 1310115001264 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cd06556 1310115001265 oligomerization interface [polypeptide binding]; other site 1310115001266 active site 1310115001267 metal binding site [ion binding]; metal-binding site 1310115001268 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 1310115001269 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1310115001270 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1310115001271 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1310115001272 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310115001273 S-adenosylmethionine binding site [chemical binding]; other site 1310115001274 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1310115001275 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1310115001276 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310115001277 S-adenosylmethionine binding site [chemical binding]; other site 1310115001278 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 1310115001279 UbiA prenyltransferase family; Region: UbiA; pfam01040 1310115001280 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310115001281 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310115001282 Predicted membrane protein [Function unknown]; Region: COG2733 1310115001283 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1310115001284 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1310115001285 non-specific DNA binding site [nucleotide binding]; other site 1310115001286 salt bridge; other site 1310115001287 sequence-specific DNA binding site [nucleotide binding]; other site 1310115001288 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 1310115001289 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 1310115001290 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1310115001291 intersubunit interface [polypeptide binding]; other site 1310115001292 active site 1310115001293 catalytic residue [active] 1310115001294 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1310115001295 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1310115001296 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 1310115001297 putative active site [active] 1310115001298 catalytic triad [active] 1310115001299 putative dimer interface [polypeptide binding]; other site 1310115001300 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 1310115001301 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 1310115001302 FAD binding domain; Region: FAD_binding_4; pfam01565 1310115001303 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1310115001304 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1310115001305 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1310115001306 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1310115001307 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1310115001308 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1310115001309 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310115001310 NAD(P) binding site [chemical binding]; other site 1310115001311 active site 1310115001312 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1310115001313 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1310115001314 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1310115001315 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 1310115001316 putative ADP-binding pocket [chemical binding]; other site 1310115001317 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1310115001318 L-lysine exporter; Region: 2a75; TIGR00948 1310115001319 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1310115001320 catalytic core [active] 1310115001321 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1310115001322 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1310115001323 dimer interface [polypeptide binding]; other site 1310115001324 phosphorylation site [posttranslational modification] 1310115001325 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1310115001326 ATP binding site [chemical binding]; other site 1310115001327 Mg2+ binding site [ion binding]; other site 1310115001328 G-X-G motif; other site 1310115001329 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1310115001330 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1310115001331 active site 1310115001332 phosphorylation site [posttranslational modification] 1310115001333 intermolecular recognition site; other site 1310115001334 dimerization interface [polypeptide binding]; other site 1310115001335 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1310115001336 DNA binding site [nucleotide binding] 1310115001337 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 1310115001338 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1310115001339 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1310115001340 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1310115001341 DNA-binding site [nucleotide binding]; DNA binding site 1310115001342 FCD domain; Region: FCD; pfam07729 1310115001343 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1310115001344 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1310115001345 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1310115001346 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1310115001347 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1310115001348 Diacylglycerol kinase catalytic domain (presumed); Region: DAGKc; smart00046 1310115001349 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1310115001350 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1310115001351 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1310115001352 DNA binding domain, excisionase family; Region: excise; TIGR01764 1310115001353 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1310115001354 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 1310115001355 putative NAD(P) binding site [chemical binding]; other site 1310115001356 active site 1310115001357 putative substrate binding site [chemical binding]; other site 1310115001358 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1310115001359 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1310115001360 putative acyl-acceptor binding pocket; other site 1310115001361 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1310115001362 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1310115001363 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310115001364 S-adenosylmethionine binding site [chemical binding]; other site 1310115001365 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1310115001366 active site 1310115001367 catalytic site [active] 1310115001368 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1310115001369 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 1310115001370 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1310115001371 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1310115001372 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 1310115001373 glutamyl-tRNA reductase; Region: hemA; TIGR01035 1310115001374 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1310115001375 tRNA; other site 1310115001376 putative tRNA binding site [nucleotide binding]; other site 1310115001377 putative NADP binding site [chemical binding]; other site 1310115001378 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1310115001379 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1310115001380 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1310115001381 domain interfaces; other site 1310115001382 active site 1310115001383 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 1310115001384 active site 1310115001385 homodimer interface [polypeptide binding]; other site 1310115001386 SAM binding site [chemical binding]; other site 1310115001387 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1310115001388 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1310115001389 active site 1310115001390 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1310115001391 dimer interface [polypeptide binding]; other site 1310115001392 active site 1310115001393 Schiff base residues; other site 1310115001394 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1310115001395 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1310115001396 active site 1310115001397 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1310115001398 anti sigma factor interaction site; other site 1310115001399 regulatory phosphorylation site [posttranslational modification]; other site 1310115001400 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1310115001401 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1310115001402 active site 1310115001403 catalytic triad [active] 1310115001404 oxyanion hole [active] 1310115001405 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 1310115001406 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310115001407 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1310115001408 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1310115001409 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1310115001410 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1310115001411 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1310115001412 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1310115001413 catalytic residue [active] 1310115001414 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1310115001415 catalytic core [active] 1310115001416 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1310115001417 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1310115001418 catalytic residues [active] 1310115001419 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1310115001420 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1310115001421 potential frameshift: common BLAST hit: gi|471336359|ref|YP_007609072.1| transmembrane protein 1310115001422 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 1310115001423 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1310115001424 AAA domain; Region: AAA_31; pfam13614 1310115001425 P-loop; other site 1310115001426 Magnesium ion binding site [ion binding]; other site 1310115001427 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1310115001428 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 1310115001429 3-oxoacyl-(acyl-carrier-protein) synthase III; Region: fabH; TIGR00747 1310115001430 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1310115001431 dimer interface [polypeptide binding]; other site 1310115001432 active site 1310115001433 CoA binding pocket [chemical binding]; other site 1310115001434 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 1310115001435 UbiA prenyltransferase family; Region: UbiA; pfam01040 1310115001436 potential frameshift: common BLAST hit: gi|471336367|ref|YP_007609080.1| 5'-methylthioadenosine phosphorylase 1310115001437 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1310115001438 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310115001439 NAD(P) binding site [chemical binding]; other site 1310115001440 active site 1310115001441 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1310115001442 Ligand binding site; other site 1310115001443 Putative Catalytic site; other site 1310115001444 DXD motif; other site 1310115001445 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3222 1310115001446 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 1310115001447 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1310115001448 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1310115001449 acyl-activating enzyme (AAE) consensus motif; other site 1310115001450 acyl-activating enzyme (AAE) consensus motif; other site 1310115001451 AMP binding site [chemical binding]; other site 1310115001452 active site 1310115001453 CoA binding site [chemical binding]; other site 1310115001454 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 1310115001455 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1310115001456 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1310115001457 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1310115001458 active site 1310115001459 short chain dehydrogenase; Provisional; Region: PRK05866 1310115001460 classical (c) SDRs; Region: SDR_c; cd05233 1310115001461 NAD(P) binding site [chemical binding]; other site 1310115001462 active site 1310115001463 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1310115001464 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1310115001465 substrate binding site [chemical binding]; other site 1310115001466 oxyanion hole (OAH) forming residues; other site 1310115001467 trimer interface [polypeptide binding]; other site 1310115001468 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1310115001469 putative active site [active] 1310115001470 homotetrameric interface [polypeptide binding]; other site 1310115001471 metal binding site [ion binding]; metal-binding site 1310115001472 Post-segregation antitoxin (ccd killing mechanism protein) encoded by the F plasmid [General function prediction only]; Region: COG5302 1310115001473 acyl-CoA synthetase; Validated; Region: PRK06188 1310115001474 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1310115001475 putative active site [active] 1310115001476 putative CoA binding site [chemical binding]; other site 1310115001477 putative AMP binding site [chemical binding]; other site 1310115001478 Amidohydrolase family; Region: Amidohydro_3; pfam07969 1310115001479 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1310115001480 active site 1310115001481 O-succinylbenzoate synthase; Provisional; Region: PRK02901 1310115001482 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1310115001483 active site 1310115001484 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1310115001485 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1310115001486 TAP-like protein; Region: Abhydrolase_4; pfam08386 1310115001487 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1310115001488 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1310115001489 dimer interface [polypeptide binding]; other site 1310115001490 tetramer interface [polypeptide binding]; other site 1310115001491 PYR/PP interface [polypeptide binding]; other site 1310115001492 TPP binding site [chemical binding]; other site 1310115001493 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1310115001494 TPP-binding site; other site 1310115001495 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1310115001496 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1310115001497 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1310115001498 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1310115001499 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310115001500 S-adenosylmethionine binding site [chemical binding]; other site 1310115001501 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1310115001502 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1310115001503 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310115001504 S-adenosylmethionine binding site [chemical binding]; other site 1310115001505 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1310115001506 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1310115001507 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1310115001508 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1310115001509 substrate binding pocket [chemical binding]; other site 1310115001510 chain length determination region; other site 1310115001511 substrate-Mg2+ binding site; other site 1310115001512 catalytic residues [active] 1310115001513 aspartate-rich region 1; other site 1310115001514 active site lid residues [active] 1310115001515 aspartate-rich region 2; other site 1310115001516 heat shock protein HtpX; Provisional; Region: PRK03072 1310115001517 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439 1310115001518 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1310115001519 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1310115001520 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1310115001521 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1310115001522 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1310115001523 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1310115001524 O-methyltransferase; Region: Methyltransf_2; pfam00891 1310115001525 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1310115001526 Cytochrome P450; Region: p450; cl12078 1310115001527 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 1310115001528 ATP cone domain; Region: ATP-cone; pfam03477 1310115001529 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 1310115001530 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 1310115001531 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 1310115001532 active site 1310115001533 dimer interface [polypeptide binding]; other site 1310115001534 effector binding site; other site 1310115001535 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1310115001536 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1310115001537 active site 1310115001538 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1310115001539 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1310115001540 nicotinate phosphoribosyltransferase; Provisional; Region: PRK12484 1310115001541 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1310115001542 active site 1310115001543 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 1310115001544 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1310115001545 putative active site [active] 1310115001546 putative metal binding site [ion binding]; other site 1310115001547 hypothetical protein; Provisional; Region: PRK07588 1310115001548 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1310115001549 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1310115001550 dimerization interface [polypeptide binding]; other site 1310115001551 putative DNA binding site [nucleotide binding]; other site 1310115001552 putative Zn2+ binding site [ion binding]; other site 1310115001553 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1310115001554 putative hydrophobic ligand binding site [chemical binding]; other site 1310115001555 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1310115001556 TIGR03086 family protein; Region: TIGR03086 1310115001557 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1310115001558 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1310115001559 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1310115001560 PE family; Region: PE; pfam00934 1310115001561 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451 1310115001562 Uncharacterized conserved protein [Function unknown]; Region: COG1656 1310115001563 Protein of unknown function DUF82; Region: DUF82; pfam01927 1310115001564 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1310115001565 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1310115001566 putative active site [active] 1310115001567 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 1310115001568 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 1310115001569 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 1310115001570 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1310115001571 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1310115001572 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1310115001573 DNA-binding site [nucleotide binding]; DNA binding site 1310115001574 FCD domain; Region: FCD; pfam07729 1310115001575 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1310115001576 Permease; Region: Permease; pfam02405 1310115001577 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1310115001578 Permease; Region: Permease; pfam02405 1310115001579 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1310115001580 mce related protein; Region: MCE; pfam02470 1310115001581 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1310115001582 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1310115001583 mce related protein; Region: MCE; pfam02470 1310115001584 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1310115001585 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1310115001586 mce related protein; Region: MCE; pfam02470 1310115001587 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1310115001588 mce related protein; Region: MCE; pfam02470 1310115001589 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1310115001590 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1310115001591 mce related protein; Region: MCE; pfam02470 1310115001592 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1310115001593 mce related protein; Region: MCE; pfam02470 1310115001594 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1310115001595 oligomeric interface; other site 1310115001596 putative active site [active] 1310115001597 homodimer interface [polypeptide binding]; other site 1310115001598 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1310115001599 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 1310115001600 AAA domain; Region: AAA_14; pfam13173 1310115001601 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1310115001602 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 1310115001603 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1310115001604 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1310115001605 ATP binding site [chemical binding]; other site 1310115001606 Mg2+ binding site [ion binding]; other site 1310115001607 G-X-G motif; other site 1310115001608 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1310115001609 dimerization interface [polypeptide binding]; other site 1310115001610 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1310115001611 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1310115001612 active site 1310115001613 phosphorylation site [posttranslational modification] 1310115001614 intermolecular recognition site; other site 1310115001615 dimerization interface [polypeptide binding]; other site 1310115001616 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1310115001617 DNA binding site [nucleotide binding] 1310115001618 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 1310115001619 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 1310115001620 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1310115001621 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 1310115001622 catalytic residues [active] 1310115001623 catalytic nucleophile [active] 1310115001624 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1310115001625 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1310115001626 Probable transposase; Region: OrfB_IS605; pfam01385 1310115001627 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 1310115001628 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 1310115001629 putative active site [active] 1310115001630 SEC-C motif; Region: SEC-C; pfam02810 1310115001631 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB-like; cd09875 1310115001632 putative active site [active] 1310115001633 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 1310115001634 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1310115001635 nucleotide binding site/active site [active] 1310115001636 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1310115001637 galactokinase; Provisional; Region: PRK00555 1310115001638 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1310115001639 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1310115001640 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 1310115001641 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 1310115001642 putative active site [active] 1310115001643 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1310115001644 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1310115001645 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1310115001646 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1310115001647 oligomeric interface; other site 1310115001648 putative active site [active] 1310115001649 homodimer interface [polypeptide binding]; other site 1310115001650 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 1310115001651 FIST N domain; Region: FIST; pfam08495 1310115001652 FIST C domain; Region: FIST_C; pfam10442 1310115001653 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 1310115001654 AAA domain; Region: AAA_30; pfam13604 1310115001655 Family description; Region: UvrD_C_2; pfam13538 1310115001656 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 1310115001657 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1310115001658 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 1310115001659 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1310115001660 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1310115001661 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1310115001662 substrate binding site [chemical binding]; other site 1310115001663 oxyanion hole (OAH) forming residues; other site 1310115001664 trimer interface [polypeptide binding]; other site 1310115001665 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1310115001666 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1310115001667 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1310115001668 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1310115001669 active site 1310115001670 catalytic site [active] 1310115001671 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 1310115001672 active site 1310115001673 catalytic site [active] 1310115001674 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1310115001675 active site 1310115001676 catalytic site [active] 1310115001677 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1310115001678 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1310115001679 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1310115001680 putative homodimer interface [polypeptide binding]; other site 1310115001681 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1310115001682 heterodimer interface [polypeptide binding]; other site 1310115001683 homodimer interface [polypeptide binding]; other site 1310115001684 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1310115001685 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1310115001686 23S rRNA interface [nucleotide binding]; other site 1310115001687 L7/L12 interface [polypeptide binding]; other site 1310115001688 putative thiostrepton binding site; other site 1310115001689 L25 interface [polypeptide binding]; other site 1310115001690 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1310115001691 mRNA/rRNA interface [nucleotide binding]; other site 1310115001692 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1310115001693 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310115001694 S-adenosylmethionine binding site [chemical binding]; other site 1310115001695 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1310115001696 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1310115001697 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310115001698 S-adenosylmethionine binding site [chemical binding]; other site 1310115001699 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1310115001700 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1310115001701 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310115001702 S-adenosylmethionine binding site [chemical binding]; other site 1310115001703 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1310115001704 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1310115001705 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310115001706 S-adenosylmethionine binding site [chemical binding]; other site 1310115001707 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1310115001708 TAP-like protein; Region: Abhydrolase_4; pfam08386 1310115001709 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1310115001710 ABC1 family; Region: ABC1; cl17513 1310115001711 N-terminal catalytic domain of class II alpha-mannosidases and similar proteins; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_like; cd10786 1310115001712 active site 1310115001713 catalytic site [active] 1310115001714 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 1310115001715 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 1310115001716 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 1310115001717 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1310115001718 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1310115001719 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1310115001720 23S rRNA interface [nucleotide binding]; other site 1310115001721 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1310115001722 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1310115001723 core dimer interface [polypeptide binding]; other site 1310115001724 peripheral dimer interface [polypeptide binding]; other site 1310115001725 L10 interface [polypeptide binding]; other site 1310115001726 L11 interface [polypeptide binding]; other site 1310115001727 putative EF-Tu interaction site [polypeptide binding]; other site 1310115001728 putative EF-G interaction site [polypeptide binding]; other site 1310115001729 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310115001730 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310115001731 WHG domain; Region: WHG; pfam13305 1310115001732 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 1310115001733 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 1310115001734 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1310115001735 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1310115001736 Walker A/P-loop; other site 1310115001737 ATP binding site [chemical binding]; other site 1310115001738 Q-loop/lid; other site 1310115001739 ABC transporter signature motif; other site 1310115001740 Walker B; other site 1310115001741 D-loop; other site 1310115001742 H-loop/switch region; other site 1310115001743 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1310115001744 putative active site [active] 1310115001745 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1310115001746 CAAX protease self-immunity; Region: Abi; pfam02517 1310115001747 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1310115001748 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1310115001749 Sulfatase; Region: Sulfatase; pfam00884 1310115001750 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1310115001751 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1310115001752 putative active site [active] 1310115001753 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1310115001754 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1310115001755 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1310115001756 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1310115001757 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1310115001758 RPB10 interaction site [polypeptide binding]; other site 1310115001759 RPB1 interaction site [polypeptide binding]; other site 1310115001760 RPB11 interaction site [polypeptide binding]; other site 1310115001761 RPB3 interaction site [polypeptide binding]; other site 1310115001762 RPB12 interaction site [polypeptide binding]; other site 1310115001763 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1310115001764 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1310115001765 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1310115001766 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1310115001767 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1310115001768 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1310115001769 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1310115001770 G-loop; other site 1310115001771 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1310115001772 DNA binding site [nucleotide binding] 1310115001773 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1310115001774 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; pfam04734 1310115001775 endonuclease IV; Provisional; Region: PRK01060 1310115001776 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1310115001777 AP (apurinic/apyrimidinic) site pocket; other site 1310115001778 DNA interaction; other site 1310115001779 Metal-binding active site; metal-binding site 1310115001780 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1310115001781 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 1310115001782 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 1310115001783 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1310115001784 active site 1310115001785 enoyl-CoA hydratase; Provisional; Region: PRK12478 1310115001786 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1310115001787 substrate binding site [chemical binding]; other site 1310115001788 oxyanion hole (OAH) forming residues; other site 1310115001789 trimer interface [polypeptide binding]; other site 1310115001790 Phenylacetic acid-responsive transcriptional repressor [Transcription]; Region: PaaX; COG3327 1310115001791 PaaX-like protein; Region: PaaX; pfam07848 1310115001792 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 1310115001793 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1310115001794 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1310115001795 substrate binding site [chemical binding]; other site 1310115001796 oxyanion hole (OAH) forming residues; other site 1310115001797 trimer interface [polypeptide binding]; other site 1310115001798 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1310115001799 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1310115001800 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 1310115001801 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 1310115001802 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310115001803 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310115001804 WHG domain; Region: WHG; pfam13305 1310115001805 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1310115001806 S17 interaction site [polypeptide binding]; other site 1310115001807 S8 interaction site; other site 1310115001808 16S rRNA interaction site [nucleotide binding]; other site 1310115001809 streptomycin interaction site [chemical binding]; other site 1310115001810 23S rRNA interaction site [nucleotide binding]; other site 1310115001811 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1310115001812 30S ribosomal protein S7; Validated; Region: PRK05302 1310115001813 elongation factor G; Reviewed; Region: PRK00007 1310115001814 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1310115001815 G1 box; other site 1310115001816 putative GEF interaction site [polypeptide binding]; other site 1310115001817 GTP/Mg2+ binding site [chemical binding]; other site 1310115001818 Switch I region; other site 1310115001819 G2 box; other site 1310115001820 G3 box; other site 1310115001821 Switch II region; other site 1310115001822 G4 box; other site 1310115001823 G5 box; other site 1310115001824 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1310115001825 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1310115001826 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1310115001827 elongation factor Tu; Reviewed; Region: PRK00049 1310115001828 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1310115001829 G1 box; other site 1310115001830 GEF interaction site [polypeptide binding]; other site 1310115001831 GTP/Mg2+ binding site [chemical binding]; other site 1310115001832 Switch I region; other site 1310115001833 G2 box; other site 1310115001834 G3 box; other site 1310115001835 Switch II region; other site 1310115001836 G4 box; other site 1310115001837 G5 box; other site 1310115001838 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1310115001839 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1310115001840 Antibiotic Binding Site [chemical binding]; other site 1310115001841 Short C-terminal domain; Region: SHOCT; pfam09851 1310115001842 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1310115001843 classical (c) SDRs; Region: SDR_c; cd05233 1310115001844 NAD(P) binding site [chemical binding]; other site 1310115001845 active site 1310115001846 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1310115001847 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1310115001848 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4427 1310115001849 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1310115001850 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310115001851 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 1310115001852 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 1310115001853 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1310115001854 FeS/SAM binding site; other site 1310115001855 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1310115001856 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 1310115001857 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1310115001858 phosphate binding site [ion binding]; other site 1310115001859 mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964 1310115001860 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 1310115001861 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1310115001862 Probable Catalytic site; other site 1310115001863 metal-binding site 1310115001864 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 1310115001865 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1310115001866 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1310115001867 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1310115001868 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1310115001869 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1310115001870 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1310115001871 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1310115001872 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1310115001873 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1310115001874 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1310115001875 putative translocon binding site; other site 1310115001876 protein-rRNA interface [nucleotide binding]; other site 1310115001877 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1310115001878 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1310115001879 G-X-X-G motif; other site 1310115001880 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1310115001881 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1310115001882 23S rRNA interface [nucleotide binding]; other site 1310115001883 5S rRNA interface [nucleotide binding]; other site 1310115001884 putative antibiotic binding site [chemical binding]; other site 1310115001885 L25 interface [polypeptide binding]; other site 1310115001886 L27 interface [polypeptide binding]; other site 1310115001887 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1310115001888 putative translocon interaction site; other site 1310115001889 23S rRNA interface [nucleotide binding]; other site 1310115001890 signal recognition particle (SRP54) interaction site; other site 1310115001891 L23 interface [polypeptide binding]; other site 1310115001892 trigger factor interaction site; other site 1310115001893 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1310115001894 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1310115001895 Sulfatase; Region: Sulfatase; pfam00884 1310115001896 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353 1310115001897 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1310115001898 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1310115001899 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1310115001900 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1310115001901 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1310115001902 RNA binding site [nucleotide binding]; other site 1310115001903 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1310115001904 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1310115001905 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1310115001906 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1310115001907 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1310115001908 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1310115001909 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1310115001910 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1310115001911 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1310115001912 5S rRNA interface [nucleotide binding]; other site 1310115001913 23S rRNA interface [nucleotide binding]; other site 1310115001914 L5 interface [polypeptide binding]; other site 1310115001915 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1310115001916 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1310115001917 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1310115001918 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1310115001919 23S rRNA binding site [nucleotide binding]; other site 1310115001920 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1310115001921 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 1310115001922 tandem repeat interface [polypeptide binding]; other site 1310115001923 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1310115001924 oligomer interface [polypeptide binding]; other site 1310115001925 active site residues [active] 1310115001926 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1310115001927 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1310115001928 tandem repeat interface [polypeptide binding]; other site 1310115001929 oligomer interface [polypeptide binding]; other site 1310115001930 active site residues [active] 1310115001931 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1310115001932 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1310115001933 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1310115001934 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1310115001935 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1310115001936 intersubunit interface [polypeptide binding]; other site 1310115001937 active site 1310115001938 Zn2+ binding site [ion binding]; other site 1310115001939 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1310115001940 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1310115001941 NAD binding site [chemical binding]; other site 1310115001942 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1310115001943 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1310115001944 nucleotide binding site [chemical binding]; other site 1310115001945 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1310115001946 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1310115001947 Coenzyme A binding pocket [chemical binding]; other site 1310115001948 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1310115001949 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1310115001950 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1310115001951 SecY translocase; Region: SecY; pfam00344 1310115001952 adenylate kinase; Reviewed; Region: adk; PRK00279 1310115001953 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1310115001954 AMP-binding site [chemical binding]; other site 1310115001955 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1310115001956 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1310115001957 active site 1310115001958 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 1310115001959 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1310115001960 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1310115001961 DNA binding residues [nucleotide binding] 1310115001962 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 1310115001963 Putative zinc-finger; Region: zf-HC2; pfam13490 1310115001964 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1310115001965 MarR family; Region: MarR; pfam01047 1310115001966 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1310115001967 TIGR03086 family protein; Region: TIGR03086 1310115001968 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 1310115001969 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1310115001970 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1310115001971 Helix-turn-helix domain; Region: HTH_17; pfam12728 1310115001972 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 1310115001973 PE family; Region: PE; pfam00934 1310115001974 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1310115001975 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1310115001976 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 1310115001977 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1310115001978 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1310115001979 active site 1310115001980 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1310115001981 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1310115001982 tetrameric interface [polypeptide binding]; other site 1310115001983 NAD binding site [chemical binding]; other site 1310115001984 catalytic residues [active] 1310115001985 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1310115001986 catalytic core [active] 1310115001987 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115001988 PPE family; Region: PPE; pfam00823 1310115001989 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310115001990 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310115001991 Helix-turn-helix domain; Region: HTH_28; pfam13518 1310115001992 Winged helix-turn helix; Region: HTH_29; pfam13551 1310115001993 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1310115001994 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1310115001995 active site 1310115001996 phosphorylation site [posttranslational modification] 1310115001997 intermolecular recognition site; other site 1310115001998 dimerization interface [polypeptide binding]; other site 1310115001999 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1310115002000 DNA binding site [nucleotide binding] 1310115002001 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1310115002002 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1310115002003 dimerization interface [polypeptide binding]; other site 1310115002004 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1310115002005 dimer interface [polypeptide binding]; other site 1310115002006 phosphorylation site [posttranslational modification] 1310115002007 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1310115002008 ATP binding site [chemical binding]; other site 1310115002009 Mg2+ binding site [ion binding]; other site 1310115002010 G-X-G motif; other site 1310115002011 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1310115002012 nucleotide binding site/active site [active] 1310115002013 HIT family signature motif; other site 1310115002014 catalytic residue [active] 1310115002015 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 1310115002016 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1310115002017 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1310115002018 NAD binding site [chemical binding]; other site 1310115002019 catalytic Zn binding site [ion binding]; other site 1310115002020 substrate binding site [chemical binding]; other site 1310115002021 structural Zn binding site [ion binding]; other site 1310115002022 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1310115002023 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1310115002024 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1310115002025 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1310115002026 Cytochrome P450; Region: p450; cl12078 1310115002027 short chain dehydrogenase; Provisional; Region: PRK07775 1310115002028 classical (c) SDRs; Region: SDR_c; cd05233 1310115002029 NAD(P) binding site [chemical binding]; other site 1310115002030 active site 1310115002031 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1310115002032 Cytochrome P450; Region: p450; cl12078 1310115002033 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310115002034 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 1310115002035 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 1310115002036 NAD binding site [chemical binding]; other site 1310115002037 catalytic residues [active] 1310115002038 short chain dehydrogenase; Provisional; Region: PRK07774 1310115002039 classical (c) SDRs; Region: SDR_c; cd05233 1310115002040 NAD(P) binding site [chemical binding]; other site 1310115002041 active site 1310115002042 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1310115002043 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 1310115002044 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1310115002045 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1310115002046 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1310115002047 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1310115002048 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1310115002049 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1310115002050 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1310115002051 Predicted esterase [General function prediction only]; Region: COG0627 1310115002052 S-formylglutathione hydrolase; Region: PLN02442 1310115002053 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1310115002054 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 1310115002055 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 1310115002056 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 1310115002057 tetramer interface [polypeptide binding]; other site 1310115002058 active site 1310115002059 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1310115002060 Cytochrome P450; Region: p450; cl12078 1310115002061 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1310115002062 ATP binding site [chemical binding]; other site 1310115002063 active site 1310115002064 substrate binding site [chemical binding]; other site 1310115002065 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1310115002066 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1310115002067 WHG domain; Region: WHG; pfam13305 1310115002068 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1310115002069 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310115002070 putative substrate translocation pore; other site 1310115002071 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310115002072 Predicted deacetylase [General function prediction only]; Region: COG3233 1310115002073 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 1310115002074 putative active site [active] 1310115002075 putative Zn binding site [ion binding]; other site 1310115002076 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1310115002077 FAD binding domain; Region: FAD_binding_2; pfam00890 1310115002078 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1310115002079 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 1310115002080 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1310115002081 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1310115002082 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1310115002083 putative active site [active] 1310115002084 catalytic triad [active] 1310115002085 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1310115002086 Transglutaminase/protease-like homologues; Region: TGc; smart00460 1310115002087 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1310115002088 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1310115002089 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1310115002090 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1310115002091 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1310115002092 DNA-binding site [nucleotide binding]; DNA binding site 1310115002093 UTRA domain; Region: UTRA; pfam07702 1310115002094 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1310115002095 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1310115002096 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1310115002097 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1310115002098 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1310115002099 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1310115002100 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1310115002101 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1310115002102 Uncharacterized protein, linocin/CFP29 homolog [Function unknown]; Region: COG1659 1310115002103 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 1310115002104 putative aminopeptidase 2; Provisional; Region: PRK02813 1310115002105 metal binding site [ion binding]; metal-binding site 1310115002106 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1310115002107 active site 1310115002108 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1310115002109 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1310115002110 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1310115002111 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1310115002112 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1310115002113 dimerization interface [polypeptide binding]; other site 1310115002114 ATP binding site [chemical binding]; other site 1310115002115 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1310115002116 dimerization interface [polypeptide binding]; other site 1310115002117 ATP binding site [chemical binding]; other site 1310115002118 CAAX protease self-immunity; Region: Abi; pfam02517 1310115002119 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1310115002120 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1310115002121 active site 1310115002122 metal binding site [ion binding]; metal-binding site 1310115002123 hexamer interface [polypeptide binding]; other site 1310115002124 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 1310115002125 amidophosphoribosyltransferase; Provisional; Region: PRK07847 1310115002126 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1310115002127 active site 1310115002128 tetramer interface [polypeptide binding]; other site 1310115002129 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1310115002130 active site 1310115002131 phosphoribosylaminoimidazole synthetase; Region: purM; TIGR00878 1310115002132 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1310115002133 dimerization interface [polypeptide binding]; other site 1310115002134 putative ATP binding site [chemical binding]; other site 1310115002135 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 1310115002136 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1310115002137 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1310115002138 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1310115002139 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1310115002140 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310115002141 catalytic residue [active] 1310115002142 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 1310115002143 heme-binding site [chemical binding]; other site 1310115002144 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 1310115002145 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1310115002146 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1310115002147 active site residue [active] 1310115002148 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1310115002149 active site residue [active] 1310115002150 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1310115002151 catalytic residues [active] 1310115002152 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1310115002153 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1310115002154 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1310115002155 DNA binding site [nucleotide binding] 1310115002156 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 1310115002157 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1310115002158 Coenzyme A binding pocket [chemical binding]; other site 1310115002159 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 1310115002160 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1310115002161 Walker A/P-loop; other site 1310115002162 ATP binding site [chemical binding]; other site 1310115002163 Q-loop/lid; other site 1310115002164 ABC transporter signature motif; other site 1310115002165 Walker B; other site 1310115002166 D-loop; other site 1310115002167 H-loop/switch region; other site 1310115002168 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1310115002169 PhoU domain; Region: PhoU; pfam01895 1310115002170 PhoU domain; Region: PhoU; pfam01895 1310115002171 cell envelope-related function transcriptional attenuator common domain; Region: lytR_cpsA_psr; TIGR00350 1310115002172 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1310115002173 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1310115002174 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1310115002175 FMN binding site [chemical binding]; other site 1310115002176 active site 1310115002177 catalytic residues [active] 1310115002178 substrate binding site [chemical binding]; other site 1310115002179 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 1310115002180 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 1310115002181 homodimer interface [polypeptide binding]; other site 1310115002182 putative substrate binding pocket [chemical binding]; other site 1310115002183 diiron center [ion binding]; other site 1310115002184 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310115002185 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 1310115002186 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1310115002187 dimerization interface [polypeptide binding]; other site 1310115002188 putative DNA binding site [nucleotide binding]; other site 1310115002189 putative Zn2+ binding site [ion binding]; other site 1310115002190 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1310115002191 dimer interface [polypeptide binding]; other site 1310115002192 catalytic motif [active] 1310115002193 nucleoside/Zn binding site; other site 1310115002194 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1310115002195 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1310115002196 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1310115002197 TIGR04255 family protein; Region: sporadTIGR04255 1310115002198 PE family; Region: PE; pfam00934 1310115002199 PE family; Region: PE; pfam00934 1310115002200 PknH-like extracellular domain; Region: PknH_C; pfam14032 1310115002201 Predicted nucleotidyltransferase [General function prediction only]; Region: COG4849 1310115002202 D-ala-D-ala dipeptidase; Region: Peptidase_M15; pfam01427 1310115002203 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310115002204 S-adenosylmethionine binding site [chemical binding]; other site 1310115002205 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 1310115002206 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310115002207 putative substrate translocation pore; other site 1310115002208 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1310115002209 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1310115002210 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1310115002211 tetramer interface [polypeptide binding]; other site 1310115002212 TPP-binding site [chemical binding]; other site 1310115002213 heterodimer interface [polypeptide binding]; other site 1310115002214 phosphorylation loop region [posttranslational modification] 1310115002215 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1310115002216 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1310115002217 active site 1310115002218 phosphorylation site [posttranslational modification] 1310115002219 intermolecular recognition site; other site 1310115002220 dimerization interface [polypeptide binding]; other site 1310115002221 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1310115002222 DNA binding residues [nucleotide binding] 1310115002223 dimerization interface [polypeptide binding]; other site 1310115002224 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1310115002225 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1310115002226 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1310115002227 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1310115002228 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1310115002229 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1310115002230 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1310115002231 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1310115002232 dimer interface [polypeptide binding]; other site 1310115002233 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310115002234 catalytic residue [active] 1310115002235 potential frameshift: common BLAST hit: gi|471336712|ref|YP_007609425.1| integral membrane transport protein 1310115002236 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1310115002237 short chain dehydrogenase; Provisional; Region: PRK05876 1310115002238 classical (c) SDRs; Region: SDR_c; cd05233 1310115002239 NAD(P) binding site [chemical binding]; other site 1310115002240 active site 1310115002241 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1310115002242 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 1310115002243 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 1310115002244 dimer interface [polypeptide binding]; other site 1310115002245 PYR/PP interface [polypeptide binding]; other site 1310115002246 TPP binding site [chemical binding]; other site 1310115002247 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1310115002248 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 1310115002249 TPP-binding site [chemical binding]; other site 1310115002250 dimer interface [polypeptide binding]; other site 1310115002251 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1310115002252 putative hydrophobic ligand binding site [chemical binding]; other site 1310115002253 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1310115002254 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1310115002255 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1310115002256 putative hydrophobic ligand binding site [chemical binding]; other site 1310115002257 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1310115002258 putative hydrophobic ligand binding site [chemical binding]; other site 1310115002259 aminotransferase; Validated; Region: PRK07777 1310115002260 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1310115002261 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310115002262 homodimer interface [polypeptide binding]; other site 1310115002263 catalytic residue [active] 1310115002264 potential frameshift: common BLAST hit: gi|449062892|ref|YP_007429975.1| acetyl-CoA acetyltransferase 1310115002265 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 1310115002266 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1310115002267 substrate binding site [chemical binding]; other site 1310115002268 oxyanion hole (OAH) forming residues; other site 1310115002269 trimer interface [polypeptide binding]; other site 1310115002270 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1310115002271 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1310115002272 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1310115002273 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1310115002274 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1310115002275 ATP binding site [chemical binding]; other site 1310115002276 putative Mg++ binding site [ion binding]; other site 1310115002277 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1310115002278 nucleotide binding region [chemical binding]; other site 1310115002279 ATP-binding site [chemical binding]; other site 1310115002280 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1310115002281 WYL domain; Region: WYL; pfam13280 1310115002282 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1310115002283 trimer interface [polypeptide binding]; other site 1310115002284 dimer interface [polypeptide binding]; other site 1310115002285 putative active site [active] 1310115002286 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1310115002287 MPT binding site; other site 1310115002288 trimer interface [polypeptide binding]; other site 1310115002289 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1310115002290 MoaE homodimer interface [polypeptide binding]; other site 1310115002291 MoaD interaction [polypeptide binding]; other site 1310115002292 active site residues [active] 1310115002293 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1310115002294 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1310115002295 MoaE interaction surface [polypeptide binding]; other site 1310115002296 MoeB interaction surface [polypeptide binding]; other site 1310115002297 thiocarboxylated glycine; other site 1310115002298 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1310115002299 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1310115002300 FeS/SAM binding site; other site 1310115002301 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1310115002302 hypothetical protein; Provisional; Region: PRK11770 1310115002303 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1310115002304 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1310115002305 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1310115002306 DNA-binding site [nucleotide binding]; DNA binding site 1310115002307 RNA-binding motif; other site 1310115002308 PE family; Region: PE; pfam00934 1310115002309 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1310115002310 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1310115002311 active site 1310115002312 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 1310115002313 FIST N domain; Region: FIST; pfam08495 1310115002314 FIST C domain; Region: FIST_C; pfam10442 1310115002315 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 1310115002316 H+ Antiporter protein; Region: 2A0121; TIGR00900 1310115002317 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 1310115002318 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115002319 PPE family; Region: PPE; pfam00823 1310115002320 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310115002321 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310115002322 Protein of unknown function (DUF2530); Region: DUF2530; pfam10745 1310115002323 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1310115002324 MarR family; Region: MarR; pfam01047 1310115002325 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1310115002326 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1310115002327 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1310115002328 Protein of unknown function (DUF2537); Region: DUF2537; pfam10801 1310115002329 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 1310115002330 phosphoserine aminotransferase, putative; Region: serC_3; TIGR01366 1310115002331 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1310115002332 catalytic residue [active] 1310115002333 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 1310115002334 Ferredoxin [Energy production and conversion]; Region: COG1146 1310115002335 4Fe-4S binding domain; Region: Fer4; pfam00037 1310115002336 ferredoxin-NADP+ reductase; Region: PLN02852 1310115002337 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1310115002338 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 1310115002339 putative dimer interface [polypeptide binding]; other site 1310115002340 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1310115002341 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1310115002342 putative catalytic site [active] 1310115002343 putative phosphate binding site [ion binding]; other site 1310115002344 putative metal binding site [ion binding]; other site 1310115002345 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 1310115002346 dimer interface [polypeptide binding]; other site 1310115002347 Citrate synthase; Region: Citrate_synt; pfam00285 1310115002348 active site 1310115002349 citrylCoA binding site [chemical binding]; other site 1310115002350 oxalacetate/citrate binding site [chemical binding]; other site 1310115002351 coenzyme A binding site [chemical binding]; other site 1310115002352 catalytic triad [active] 1310115002353 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1310115002354 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1310115002355 DNA binding residues [nucleotide binding] 1310115002356 dimerization interface [polypeptide binding]; other site 1310115002357 Predicted ATPase [General function prediction only]; Region: COG3903 1310115002358 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1310115002359 cyclase homology domain; Region: CHD; cd07302 1310115002360 nucleotidyl binding site; other site 1310115002361 metal binding site [ion binding]; metal-binding site 1310115002362 dimer interface [polypeptide binding]; other site 1310115002363 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1310115002364 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1310115002365 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1310115002366 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1310115002367 AAA ATPase domain; Region: AAA_16; pfam13191 1310115002368 Predicted ATPase [General function prediction only]; Region: COG3903 1310115002369 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1310115002370 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1310115002371 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1310115002372 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1310115002373 dimer interface [polypeptide binding]; other site 1310115002374 active site 1310115002375 citrylCoA binding site [chemical binding]; other site 1310115002376 NADH binding [chemical binding]; other site 1310115002377 cationic pore residues; other site 1310115002378 oxalacetate/citrate binding site [chemical binding]; other site 1310115002379 coenzyme A binding site [chemical binding]; other site 1310115002380 catalytic triad [active] 1310115002381 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1310115002382 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1310115002383 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 1310115002384 BON domain; Region: BON; pfam04972 1310115002385 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1310115002386 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1310115002387 ligand binding site [chemical binding]; other site 1310115002388 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 1310115002389 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1310115002390 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1310115002391 dimerization interface [polypeptide binding]; other site 1310115002392 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1310115002393 dimer interface [polypeptide binding]; other site 1310115002394 phosphorylation site [posttranslational modification] 1310115002395 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1310115002396 Mg2+ binding site [ion binding]; other site 1310115002397 G-X-G motif; other site 1310115002398 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1310115002399 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1310115002400 active site 1310115002401 phosphorylation site [posttranslational modification] 1310115002402 intermolecular recognition site; other site 1310115002403 dimerization interface [polypeptide binding]; other site 1310115002404 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1310115002405 DNA binding site [nucleotide binding] 1310115002406 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 1310115002407 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; COG0825 1310115002408 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1310115002409 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1310115002410 substrate binding site [chemical binding]; other site 1310115002411 oxyanion hole (OAH) forming residues; other site 1310115002412 trimer interface [polypeptide binding]; other site 1310115002413 potential frameshift: common BLAST hit: gi|433641026|ref|YP_007286785.1| Conserved exported protein of unknown function 1310115002414 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1310115002415 Beta-lactamase; Region: Beta-lactamase; pfam00144 1310115002416 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 1310115002417 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1310115002418 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1310115002419 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1310115002420 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 1310115002421 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1310115002422 hydrophobic ligand binding site; other site 1310115002423 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1310115002424 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1310115002425 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1310115002426 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1310115002427 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 1310115002428 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 1310115002429 potential frameshift: common BLAST hit: gi|449062952|ref|YP_007430035.1| acetyl-CoA acetyltransferase 1310115002430 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115002431 PPE family; Region: PPE; pfam00823 1310115002432 PE family; Region: PE; pfam00934 1310115002433 BCCT family transporter; Region: BCCT; pfam02028 1310115002434 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 1310115002435 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1310115002436 Coenzyme A binding pocket [chemical binding]; other site 1310115002437 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1310115002438 MULE transposase domain; Region: MULE; pfam10551 1310115002439 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1310115002440 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 1310115002441 catalytic residues [active] 1310115002442 catalytic nucleophile [active] 1310115002443 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1310115002444 Probable transposase; Region: OrfB_IS605; pfam01385 1310115002445 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1310115002446 putative active site pocket [active] 1310115002447 dimerization interface [polypeptide binding]; other site 1310115002448 putative catalytic residue [active] 1310115002449 Phage-related replication protein [General function prediction only]; Region: COG4195 1310115002450 manganese transport protein MntH; Reviewed; Region: PRK00701 1310115002451 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1310115002452 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1310115002453 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1310115002454 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1310115002455 short chain dehydrogenase; Provisional; Region: PRK07814 1310115002456 classical (c) SDRs; Region: SDR_c; cd05233 1310115002457 NAD(P) binding site [chemical binding]; other site 1310115002458 active site 1310115002459 phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975 1310115002460 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1310115002461 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1310115002462 dimer interface [polypeptide binding]; other site 1310115002463 conserved gate region; other site 1310115002464 putative PBP binding loops; other site 1310115002465 ABC-ATPase subunit interface; other site 1310115002466 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1310115002467 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1310115002468 dimer interface [polypeptide binding]; other site 1310115002469 conserved gate region; other site 1310115002470 putative PBP binding loops; other site 1310115002471 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1310115002472 ABC-ATPase subunit interface; other site 1310115002473 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1310115002474 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1310115002475 active site 1310115002476 ATP binding site [chemical binding]; other site 1310115002477 substrate binding site [chemical binding]; other site 1310115002478 activation loop (A-loop); other site 1310115002479 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1310115002480 NHL repeat; Region: NHL; pfam01436 1310115002481 NHL repeat; Region: NHL; pfam01436 1310115002482 NHL repeat; Region: NHL; pfam01436 1310115002483 NHL repeat; Region: NHL; pfam01436 1310115002484 NHL repeat; Region: NHL; pfam01436 1310115002485 PBP superfamily domain; Region: PBP_like_2; cl17296 1310115002486 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14271 1310115002487 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1310115002488 Walker A/P-loop; other site 1310115002489 ATP binding site [chemical binding]; other site 1310115002490 Q-loop/lid; other site 1310115002491 ABC transporter signature motif; other site 1310115002492 Walker B; other site 1310115002493 D-loop; other site 1310115002494 H-loop/switch region; other site 1310115002495 phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975 1310115002496 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1310115002497 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1310115002498 dimer interface [polypeptide binding]; other site 1310115002499 conserved gate region; other site 1310115002500 putative PBP binding loops; other site 1310115002501 ABC-ATPase subunit interface; other site 1310115002502 potential frameshift: common BLAST hit: gi|471336807|ref|YP_007609520.1| phosphate ABC transporter transmembrane protein 1310115002503 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 1310115002504 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1310115002505 putative DNA binding site [nucleotide binding]; other site 1310115002506 putative homodimer interface [polypeptide binding]; other site 1310115002507 potential frameshift: common BLAST hit: gi|471336809|ref|YP_007609522.1| ATP-dependent DNA ligase 1310115002508 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1310115002509 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1310115002510 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1310115002511 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1310115002512 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1310115002513 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1310115002514 anti sigma factor interaction site; other site 1310115002515 regulatory phosphorylation site [posttranslational modification]; other site 1310115002516 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1310115002517 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1310115002518 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1310115002519 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1310115002520 short chain dehydrogenase; Provisional; Region: PRK08251 1310115002521 classical (c) SDR, subgroup 6; Region: SDR_c6; cd05350 1310115002522 putative NAD(P) binding site [chemical binding]; other site 1310115002523 active site 1310115002524 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1310115002525 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1310115002526 active site 1310115002527 dimer interface [polypeptide binding]; other site 1310115002528 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1310115002529 dimer interface [polypeptide binding]; other site 1310115002530 active site 1310115002531 Predicted esterase [General function prediction only]; Region: COG0627 1310115002532 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 1310115002533 hypothetical protein; Provisional; Region: PRK07857 1310115002534 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1310115002535 Part of AAA domain; Region: AAA_19; pfam13245 1310115002536 Family description; Region: UvrD_C_2; pfam13538 1310115002537 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1310115002538 potential frameshift: common BLAST hit: gi|433626038|ref|YP_007259667.1| Conserved protein of unknown function, possibly extracellular 1310115002539 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1310115002540 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1310115002541 CoA-ligase; Region: Ligase_CoA; pfam00549 1310115002542 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1310115002543 CoA binding domain; Region: CoA_binding; smart00881 1310115002544 CoA-ligase; Region: Ligase_CoA; pfam00549 1310115002545 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1310115002546 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1310115002547 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1310115002548 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1310115002549 active site 1310115002550 substrate binding site [chemical binding]; other site 1310115002551 cosubstrate binding site; other site 1310115002552 catalytic site [active] 1310115002553 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1310115002554 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1310115002555 purine monophosphate binding site [chemical binding]; other site 1310115002556 dimer interface [polypeptide binding]; other site 1310115002557 putative catalytic residues [active] 1310115002558 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1310115002559 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1310115002560 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 1310115002561 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1310115002562 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 1310115002563 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1310115002564 metal ion-dependent adhesion site (MIDAS); other site 1310115002565 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1310115002566 homotetrameric interface [polypeptide binding]; other site 1310115002567 putative active site [active] 1310115002568 metal binding site [ion binding]; metal-binding site 1310115002569 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1310115002570 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1310115002571 Thermus thermophilus CsoR, a Cu(I)-sensing transcriptional regulator, and related domains; this domain family was previously known as part of DUF156; Region: TthCsoR-like_DUF156; cd10151 1310115002572 putative homodimer interface [polypeptide binding]; other site 1310115002573 putative homotetramer interface [polypeptide binding]; other site 1310115002574 allosteric switch controlling residues; other site 1310115002575 putative metal binding site [ion binding]; other site 1310115002576 putative homodimer-homodimer interface [polypeptide binding]; other site 1310115002577 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 1310115002578 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1310115002579 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1310115002580 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1310115002581 potential frameshift: common BLAST hit: gi|471336848|ref|YP_007609561.1| enoyl-CoA hydratase 1310115002582 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1310115002583 active site 1310115002584 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1310115002585 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1310115002586 active site 1310115002587 potential frameshift: common BLAST hit: gi|385990423|ref|YP_005908721.1| acetyl-/propionyl-CoA carboxylase alpha subunit accA2 1310115002588 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1310115002589 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1310115002590 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1310115002591 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1310115002592 active site 1310115002593 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 1310115002594 PE family; Region: PE; pfam00934 1310115002595 PE family; Region: PE; pfam00934 1310115002596 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1310115002597 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1310115002598 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1310115002599 PE family; Region: PE; pfam00934 1310115002600 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1310115002601 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1310115002602 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1310115002603 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1310115002604 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1310115002605 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1310115002606 active site 1310115002607 phosphorylation site [posttranslational modification] 1310115002608 intermolecular recognition site; other site 1310115002609 dimerization interface [polypeptide binding]; other site 1310115002610 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1310115002611 DNA binding site [nucleotide binding] 1310115002612 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1310115002613 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1310115002614 dimerization interface [polypeptide binding]; other site 1310115002615 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1310115002616 dimer interface [polypeptide binding]; other site 1310115002617 phosphorylation site [posttranslational modification] 1310115002618 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1310115002619 ATP binding site [chemical binding]; other site 1310115002620 Mg2+ binding site [ion binding]; other site 1310115002621 G-X-G motif; other site 1310115002622 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1310115002623 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1310115002624 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1310115002625 MPT binding site; other site 1310115002626 trimer interface [polypeptide binding]; other site 1310115002627 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1310115002628 Large-conductance mechanosensitive channel, MscL; Region: MscL; pfam01741 1310115002629 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1310115002630 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1310115002631 Walker A/P-loop; other site 1310115002632 ATP binding site [chemical binding]; other site 1310115002633 Q-loop/lid; other site 1310115002634 ABC transporter signature motif; other site 1310115002635 Walker B; other site 1310115002636 D-loop; other site 1310115002637 H-loop/switch region; other site 1310115002638 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1310115002639 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1310115002640 FtsX-like permease family; Region: FtsX; pfam02687 1310115002641 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1310115002642 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1310115002643 FtsX-like permease family; Region: FtsX; pfam02687 1310115002644 Predicted secreted hydrolase [General function prediction only]; Region: COG5621 1310115002645 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1310115002646 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1310115002647 substrate binding pocket [chemical binding]; other site 1310115002648 chain length determination region; other site 1310115002649 substrate-Mg2+ binding site; other site 1310115002650 catalytic residues [active] 1310115002651 aspartate-rich region 1; other site 1310115002652 active site lid residues [active] 1310115002653 aspartate-rich region 2; other site 1310115002654 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1310115002655 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2331 1310115002656 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 1310115002657 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1310115002658 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 1310115002659 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1310115002660 active site 1310115002661 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1310115002662 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1310115002663 dimer interface [polypeptide binding]; other site 1310115002664 putative functional site; other site 1310115002665 putative MPT binding site; other site 1310115002666 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1310115002667 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1310115002668 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310115002669 S-adenosylmethionine binding site [chemical binding]; other site 1310115002670 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1310115002671 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1310115002672 ligand binding site [chemical binding]; other site 1310115002673 flexible hinge region; other site 1310115002674 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1310115002675 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1310115002676 Coenzyme A binding pocket [chemical binding]; other site 1310115002677 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 1310115002678 arginine deiminase; Provisional; Region: PRK01388 1310115002679 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 1310115002680 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1310115002681 Predicted methyltransferases [General function prediction only]; Region: COG0313 1310115002682 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1310115002683 putative SAM binding site [chemical binding]; other site 1310115002684 putative homodimer interface [polypeptide binding]; other site 1310115002685 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 1310115002686 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 1310115002687 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 1310115002688 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1310115002689 active site 1310115002690 HIGH motif; other site 1310115002691 KMSKS motif; other site 1310115002692 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1310115002693 tRNA binding surface [nucleotide binding]; other site 1310115002694 anticodon binding site; other site 1310115002695 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1310115002696 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1310115002697 active site 1310115002698 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 1310115002699 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1310115002700 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1310115002701 G5 domain; Region: G5; pfam07501 1310115002702 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1310115002703 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1310115002704 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310115002705 S-adenosylmethionine binding site [chemical binding]; other site 1310115002706 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 1310115002707 Increased loss of mitochondrial DNA protein 1; Region: Ilm1; pfam10311 1310115002708 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1310115002709 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 1310115002710 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1310115002711 acyl-activating enzyme (AAE) consensus motif; other site 1310115002712 AMP binding site [chemical binding]; other site 1310115002713 active site 1310115002714 CoA binding site [chemical binding]; other site 1310115002715 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1310115002716 putative active site [active] 1310115002717 catalytic residue [active] 1310115002718 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1310115002719 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 1310115002720 5S rRNA interface [nucleotide binding]; other site 1310115002721 CTC domain interface [polypeptide binding]; other site 1310115002722 L16 interface [polypeptide binding]; other site 1310115002723 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 1310115002724 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1310115002725 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 1310115002726 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1310115002727 active site 1310115002728 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 1310115002729 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1310115002730 Substrate binding site; other site 1310115002731 Mg++ binding site; other site 1310115002732 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1310115002733 active site 1310115002734 substrate binding site [chemical binding]; other site 1310115002735 CoA binding site [chemical binding]; other site 1310115002736 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310115002737 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310115002738 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1310115002739 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1310115002740 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1310115002741 ATP binding site [chemical binding]; other site 1310115002742 putative Mg++ binding site [ion binding]; other site 1310115002743 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1310115002744 nucleotide binding region [chemical binding]; other site 1310115002745 ATP-binding site [chemical binding]; other site 1310115002746 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1310115002747 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 1310115002748 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1310115002749 homodimer interface [polypeptide binding]; other site 1310115002750 metal binding site [ion binding]; metal-binding site 1310115002751 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 1310115002752 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1310115002753 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1310115002754 enolase; Provisional; Region: eno; PRK00077 1310115002755 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1310115002756 dimer interface [polypeptide binding]; other site 1310115002757 metal binding site [ion binding]; metal-binding site 1310115002758 substrate binding pocket [chemical binding]; other site 1310115002759 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1310115002760 Septum formation initiator; Region: DivIC; pfam04977 1310115002761 Uncharacterized conserved protein [Function unknown]; Region: COG1507 1310115002762 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1310115002763 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1310115002764 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 1310115002765 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1310115002766 active site 1310115002767 phosphorylation site [posttranslational modification] 1310115002768 intermolecular recognition site; other site 1310115002769 dimerization interface [polypeptide binding]; other site 1310115002770 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1310115002771 DNA binding site [nucleotide binding] 1310115002772 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1310115002773 ATP binding site [chemical binding]; other site 1310115002774 G-X-G motif; other site 1310115002775 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1310115002776 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1310115002777 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1310115002778 Ligand Binding Site [chemical binding]; other site 1310115002779 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1310115002780 dimer interface [polypeptide binding]; other site 1310115002781 phosphorylation site [posttranslational modification] 1310115002782 K+-transporting ATPase, KdpA; Region: kdpA; TIGR00680 1310115002783 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1310115002784 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 1310115002785 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1310115002786 K+-transporting ATPase, c chain; Region: KdpC; cl00944 1310115002787 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1310115002788 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1310115002789 dimer interface [polypeptide binding]; other site 1310115002790 phosphorylation site [posttranslational modification] 1310115002791 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1310115002792 ATP binding site [chemical binding]; other site 1310115002793 Mg2+ binding site [ion binding]; other site 1310115002794 G-X-G motif; other site 1310115002795 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1310115002796 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1310115002797 active site 1310115002798 phosphorylation site [posttranslational modification] 1310115002799 intermolecular recognition site; other site 1310115002800 dimerization interface [polypeptide binding]; other site 1310115002801 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1310115002802 DNA binding site [nucleotide binding] 1310115002803 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1310115002804 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1310115002805 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1310115002806 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1310115002807 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1310115002808 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115002809 PPE family; Region: PPE; pfam00823 1310115002810 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1310115002811 PE family; Region: PE; pfam00934 1310115002812 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1310115002813 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1310115002814 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1310115002815 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1310115002816 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1310115002817 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1310115002818 Predicted transcriptional regulator [Transcription]; Region: COG5340 1310115002819 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1310115002820 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 1310115002821 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1310115002822 MULE transposase domain; Region: MULE; pfam10551 1310115002823 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1310115002824 MarR family; Region: MarR_2; pfam12802 1310115002825 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310115002826 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1310115002827 NAD(P) binding site [chemical binding]; other site 1310115002828 active site 1310115002829 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 1310115002830 Helix-turn-helix domain; Region: HTH_17; pfam12728 1310115002831 Fic/DOC family; Region: Fic; pfam02661 1310115002832 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1310115002833 Domain of unknown function (DUF427); Region: DUF427; cl00998 1310115002834 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 1310115002835 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1310115002836 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1310115002837 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1310115002838 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 1310115002839 dimer interface [polypeptide binding]; other site 1310115002840 acyl-activating enzyme (AAE) consensus motif; other site 1310115002841 putative active site [active] 1310115002842 AMP binding site [chemical binding]; other site 1310115002843 putative CoA binding site [chemical binding]; other site 1310115002844 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1310115002845 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 1310115002846 hydrophobic ligand binding site; other site 1310115002847 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 1310115002848 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1310115002849 putative active site [active] 1310115002850 putative dimer interface [polypeptide binding]; other site 1310115002851 Patatin-like phospholipase; Region: Patatin; pfam01734 1310115002852 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1310115002853 nucleophile elbow; other site 1310115002854 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1310115002855 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 1310115002856 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1310115002857 active site residue [active] 1310115002858 PE family; Region: PE; pfam00934 1310115002859 PE family; Region: PE; pfam00934 1310115002860 Predicted membrane protein [Function unknown]; Region: COG4425 1310115002861 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 1310115002862 enoyl-CoA hydratase; Provisional; Region: PRK05862 1310115002863 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1310115002864 substrate binding site [chemical binding]; other site 1310115002865 oxyanion hole (OAH) forming residues; other site 1310115002866 trimer interface [polypeptide binding]; other site 1310115002867 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1310115002868 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1310115002869 substrate binding site [chemical binding]; other site 1310115002870 oxyanion hole (OAH) forming residues; other site 1310115002871 trimer interface [polypeptide binding]; other site 1310115002872 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1310115002873 Predicted membrane protein [Function unknown]; Region: COG4760 1310115002874 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1310115002875 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1310115002876 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 1310115002877 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1310115002878 dimer interface [polypeptide binding]; other site 1310115002879 active site 1310115002880 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 1310115002881 active site 1310115002882 catalytic triad [active] 1310115002883 oxyanion hole [active] 1310115002884 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1310115002885 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1310115002886 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 1310115002887 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1310115002888 dimer interface [polypeptide binding]; other site 1310115002889 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310115002890 catalytic residue [active] 1310115002891 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 1310115002892 RDD family; Region: RDD; pfam06271 1310115002893 cystathionine gamma-synthase; Provisional; Region: PRK07811 1310115002894 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1310115002895 homodimer interface [polypeptide binding]; other site 1310115002896 substrate-cofactor binding pocket; other site 1310115002897 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310115002898 catalytic residue [active] 1310115002899 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1310115002900 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1310115002901 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1310115002902 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 1310115002903 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 1310115002904 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1310115002905 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 1310115002906 catalytic residues [active] 1310115002907 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 1310115002908 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1310115002909 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1310115002910 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1310115002911 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1310115002912 catalytic residue [active] 1310115002913 putative FPP diphosphate binding site; other site 1310115002914 putative FPP binding hydrophobic cleft; other site 1310115002915 dimer interface [polypeptide binding]; other site 1310115002916 putative IPP diphosphate binding site; other site 1310115002917 PE family; Region: PE; pfam00934 1310115002918 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1310115002919 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1310115002920 putative IPP diphosphate binding site; other site 1310115002921 PE family; Region: PE; pfam00934 1310115002922 Glycosyl hydrolase family 12; Region: Glyco_hydro_12; pfam01670 1310115002923 PE family; Region: PE; pfam00934 1310115002924 pantothenate kinase; Provisional; Region: PRK05439 1310115002925 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1310115002926 ATP-binding site [chemical binding]; other site 1310115002927 CoA-binding site [chemical binding]; other site 1310115002928 Mg2+-binding site [ion binding]; other site 1310115002929 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1310115002930 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1310115002931 dimer interface [polypeptide binding]; other site 1310115002932 active site 1310115002933 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1310115002934 folate binding site [chemical binding]; other site 1310115002935 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1310115002936 dinuclear metal binding motif [ion binding]; other site 1310115002937 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1310115002938 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1310115002939 putative active site [active] 1310115002940 PhoH-like protein; Region: PhoH; pfam02562 1310115002941 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1310115002942 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1310115002943 NodB motif; other site 1310115002944 active site 1310115002945 catalytic site [active] 1310115002946 metal binding site [ion binding]; metal-binding site 1310115002947 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1310115002948 Class II fumarases; Region: Fumarase_classII; cd01362 1310115002949 active site 1310115002950 tetramer interface [polypeptide binding]; other site 1310115002951 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1310115002952 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1310115002953 putative active site [active] 1310115002954 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 1310115002955 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1310115002956 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1310115002957 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1310115002958 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1310115002959 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1310115002960 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1310115002961 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1310115002962 3beta-hydroxysteroid dehydrogenases (3b-HSD)-like, extended (e) SDRs; Region: 3b-HSD-like_SDR_e; cd05241 1310115002963 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 1310115002964 putative NAD(P) binding site [chemical binding]; other site 1310115002965 active site 1310115002966 putative substrate binding site [chemical binding]; other site 1310115002967 exodeoxyribonuclease VII, small subunit; Region: xseB; TIGR01280 1310115002968 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 1310115002969 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1310115002970 generic binding surface II; other site 1310115002971 generic binding surface I; other site 1310115002972 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1310115002973 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1310115002974 Yip1 domain; Region: Yip1; pfam04893 1310115002975 GTP-binding protein YchF; Reviewed; Region: PRK09601 1310115002976 YchF GTPase; Region: YchF; cd01900 1310115002977 G1 box; other site 1310115002978 GTP/Mg2+ binding site [chemical binding]; other site 1310115002979 Switch I region; other site 1310115002980 G2 box; other site 1310115002981 Switch II region; other site 1310115002982 G3 box; other site 1310115002983 G4 box; other site 1310115002984 G5 box; other site 1310115002985 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1310115002986 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 1310115002987 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487 1310115002988 putative active site [active] 1310115002989 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1310115002990 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1310115002991 cyclase homology domain; Region: CHD; cd07302 1310115002992 nucleotidyl binding site; other site 1310115002993 metal binding site [ion binding]; metal-binding site 1310115002994 dimer interface [polypeptide binding]; other site 1310115002995 glucose-6-phosphate 1-dehydrogenase; Region: zwf; TIGR00871 1310115002996 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1310115002997 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1310115002998 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1310115002999 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd_rel; TIGR00872 1310115003000 potential frameshift: common BLAST hit: gi|449063184|ref|YP_007430267.1| alpha/beta hydrolase 1310115003001 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1310115003002 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1310115003003 pyruvate phosphate dikinase; Provisional; Region: PRK05878 1310115003004 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1310115003005 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 1310115003006 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1310115003007 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1310115003008 active site 1310115003009 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1310115003010 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1310115003011 non-specific DNA binding site [nucleotide binding]; other site 1310115003012 salt bridge; other site 1310115003013 sequence-specific DNA binding site [nucleotide binding]; other site 1310115003014 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1310115003015 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1310115003016 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1310115003017 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 1310115003018 citrate synthase; Provisional; Region: PRK14033 1310115003019 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 1310115003020 oxalacetate binding site [chemical binding]; other site 1310115003021 citrylCoA binding site [chemical binding]; other site 1310115003022 coenzyme A binding site [chemical binding]; other site 1310115003023 catalytic triad [active] 1310115003024 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 1310115003025 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1310115003026 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1310115003027 THF binding site; other site 1310115003028 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1310115003029 substrate binding site [chemical binding]; other site 1310115003030 THF binding site; other site 1310115003031 zinc-binding site [ion binding]; other site 1310115003032 PPE family; Region: PPE; pfam00823 1310115003033 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1310115003034 active site 1310115003035 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1310115003036 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1310115003037 substrate binding site [chemical binding]; other site 1310115003038 oxyanion hole (OAH) forming residues; other site 1310115003039 enoyl-CoA hydratase; Provisional; Region: PRK06494 1310115003040 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1310115003041 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 1310115003042 CAAX protease self-immunity; Region: Abi; pfam02517 1310115003043 enoyl-CoA hydratase; Provisional; Region: PRK06688 1310115003044 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 1310115003045 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1310115003046 trimer interface [polypeptide binding]; other site 1310115003047 enoyl-CoA hydratase; Provisional; Region: PRK06688 1310115003048 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1310115003049 substrate binding site [chemical binding]; other site 1310115003050 oxyanion hole (OAH) forming residues; other site 1310115003051 trimer interface [polypeptide binding]; other site 1310115003052 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1310115003053 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1310115003054 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 1310115003055 NAD binding site [chemical binding]; other site 1310115003056 homodimer interface [polypeptide binding]; other site 1310115003057 homotetramer interface [polypeptide binding]; other site 1310115003058 active site 1310115003059 MMPL family; Region: MMPL; pfam03176 1310115003060 MMPL family; Region: MMPL; pfam03176 1310115003061 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1310115003062 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1310115003063 active site 1310115003064 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1310115003065 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1310115003066 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1310115003067 NAD-dependent deacetylase; Provisional; Region: PRK00481 1310115003068 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 1310115003069 NAD+ binding site [chemical binding]; other site 1310115003070 substrate binding site [chemical binding]; other site 1310115003071 Zn binding site [ion binding]; other site 1310115003072 Predicted transcriptional regulators [Transcription]; Region: COG1725 1310115003073 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1310115003074 DNA-binding site [nucleotide binding]; DNA binding site 1310115003075 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1310115003076 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1310115003077 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 1310115003078 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1310115003079 uncharacterized HhH-GPD family protein; Region: TIGR03252 1310115003080 minor groove reading motif; other site 1310115003081 helix-hairpin-helix signature motif; other site 1310115003082 mannosyltransferase; Provisional; Region: pimE; PRK13375 1310115003083 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 1310115003084 aromatic arch; other site 1310115003085 DCoH dimer interaction site [polypeptide binding]; other site 1310115003086 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1310115003087 DCoH tetramer interaction site [polypeptide binding]; other site 1310115003088 substrate binding site [chemical binding]; other site 1310115003089 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1310115003090 active site 1310115003091 8-oxo-dGMP binding site [chemical binding]; other site 1310115003092 nudix motif; other site 1310115003093 metal binding site [ion binding]; metal-binding site 1310115003094 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1310115003095 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1310115003096 [4Fe-4S] binding site [ion binding]; other site 1310115003097 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1310115003098 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1310115003099 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1310115003100 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1310115003101 molybdopterin cofactor binding site; other site 1310115003102 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1310115003103 nitrate reductase molybdenum cofactor assembly chaperone; Region: narJ; TIGR00684 1310115003104 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 1310115003105 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1310115003106 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1310115003107 G1 box; other site 1310115003108 putative GEF interaction site [polypeptide binding]; other site 1310115003109 GTP/Mg2+ binding site [chemical binding]; other site 1310115003110 Switch I region; other site 1310115003111 G2 box; other site 1310115003112 G3 box; other site 1310115003113 Switch II region; other site 1310115003114 G4 box; other site 1310115003115 G5 box; other site 1310115003116 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1310115003117 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1310115003118 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1310115003119 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1310115003120 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1310115003121 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310115003122 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310115003123 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115003124 PPE family; Region: PPE; pfam00823 1310115003125 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1310115003126 PE family; Region: PE; pfam00934 1310115003127 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 1310115003128 PE family; Region: PE; pfam00934 1310115003129 FO synthase; Reviewed; Region: fbiC; PRK09234 1310115003130 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1310115003131 FeS/SAM binding site; other site 1310115003132 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1310115003133 FeS/SAM binding site; other site 1310115003134 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1310115003135 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 1310115003136 active site 1310115003137 FMN binding site [chemical binding]; other site 1310115003138 2,4-decadienoyl-CoA binding site; other site 1310115003139 catalytic residue [active] 1310115003140 4Fe-4S cluster binding site [ion binding]; other site 1310115003141 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1310115003142 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1310115003143 Predicted transcriptional regulators [Transcription]; Region: COG1695 1310115003144 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1310115003145 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1310115003146 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 1310115003147 4Fe-4S binding domain; Region: Fer4; pfam00037 1310115003148 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 1310115003149 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1310115003150 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310115003151 homodimer interface [polypeptide binding]; other site 1310115003152 catalytic residue [active] 1310115003153 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1310115003154 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 1310115003155 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1310115003156 ATP binding site [chemical binding]; other site 1310115003157 putative Mg++ binding site [ion binding]; other site 1310115003158 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1310115003159 ATP-binding site [chemical binding]; other site 1310115003160 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1310115003161 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1310115003162 active site 1310115003163 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1310115003164 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1310115003165 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310115003166 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1310115003167 Enoylreductase; Region: PKS_ER; smart00829 1310115003168 NAD(P) binding site [chemical binding]; other site 1310115003169 KR domain; Region: KR; pfam08659 1310115003170 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1310115003171 putative NADP binding site [chemical binding]; other site 1310115003172 active site 1310115003173 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1310115003174 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1310115003175 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1310115003176 PE-PPE domain; Region: PE-PPE; pfam08237 1310115003177 acyl-CoA synthetase; Validated; Region: PRK05850 1310115003178 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1310115003179 acyl-activating enzyme (AAE) consensus motif; other site 1310115003180 active site 1310115003181 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1310115003182 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1310115003183 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 1310115003184 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 1310115003185 Glutamate binding site [chemical binding]; other site 1310115003186 NAD binding site [chemical binding]; other site 1310115003187 catalytic residues [active] 1310115003188 Proline dehydrogenase; Region: Pro_dh; cl03282 1310115003189 RNA polymerase sigma factor SigI; Provisional; Region: sigI; PRK09635 1310115003190 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1310115003191 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1310115003192 DNA binding residues [nucleotide binding] 1310115003193 haloalkane dehalogenase; Provisional; Region: PRK03204 1310115003194 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1310115003195 catalytic site [active] 1310115003196 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1310115003197 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 1310115003198 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1310115003199 PGAP1-like protein; Region: PGAP1; pfam07819 1310115003200 acyl-CoA synthetase; Validated; Region: PRK07787 1310115003201 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1310115003202 acyl-activating enzyme (AAE) consensus motif; other site 1310115003203 AMP binding site [chemical binding]; other site 1310115003204 active site 1310115003205 CoA binding site [chemical binding]; other site 1310115003206 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1310115003207 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1310115003208 PE family; Region: PE; pfam00934 1310115003209 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115003210 PPE family; Region: PPE; pfam00823 1310115003211 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1310115003212 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1310115003213 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1310115003214 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1310115003215 MULE transposase domain; Region: MULE; pfam10551 1310115003216 metabolite-proton symporter; Region: 2A0106; TIGR00883 1310115003217 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310115003218 putative substrate translocation pore; other site 1310115003219 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 1310115003220 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 1310115003221 putative trimer interface [polypeptide binding]; other site 1310115003222 putative CoA binding site [chemical binding]; other site 1310115003223 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 1310115003224 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 1310115003225 metal binding site [ion binding]; metal-binding site 1310115003226 putative dimer interface [polypeptide binding]; other site 1310115003227 TIGR00730 family protein; Region: TIGR00730 1310115003228 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 1310115003229 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 1310115003230 acyl-activating enzyme (AAE) consensus motif; other site 1310115003231 putative AMP binding site [chemical binding]; other site 1310115003232 putative active site [active] 1310115003233 putative CoA binding site [chemical binding]; other site 1310115003234 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1310115003235 dihydropteroate synthase; Region: DHPS; TIGR01496 1310115003236 substrate binding pocket [chemical binding]; other site 1310115003237 dimer interface [polypeptide binding]; other site 1310115003238 inhibitor binding site; inhibition site 1310115003239 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 1310115003240 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1310115003241 DivIVA domain; Region: DivI1A_domain; TIGR03544 1310115003242 DNA-3-methyladenine glycosylase I; Region: tag; TIGR00624 1310115003243 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 1310115003244 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 1310115003245 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1310115003246 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 1310115003247 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1310115003248 ligand binding site; other site 1310115003249 oligomer interface; other site 1310115003250 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1310115003251 dimer interface [polypeptide binding]; other site 1310115003252 N-terminal domain interface [polypeptide binding]; other site 1310115003253 sulfate 1 binding site; other site 1310115003254 PE family; Region: PE; pfam00934 1310115003255 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 1310115003256 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1310115003257 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1310115003258 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 1310115003259 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1310115003260 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1310115003261 Walker A/P-loop; other site 1310115003262 ATP binding site [chemical binding]; other site 1310115003263 Q-loop/lid; other site 1310115003264 ABC transporter signature motif; other site 1310115003265 Walker B; other site 1310115003266 D-loop; other site 1310115003267 H-loop/switch region; other site 1310115003268 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1310115003269 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310115003270 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1310115003271 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310115003272 S-adenosylmethionine binding site [chemical binding]; other site 1310115003273 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 1310115003274 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1310115003275 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1310115003276 DNA binding residues [nucleotide binding] 1310115003277 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1310115003278 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1310115003279 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1310115003280 protein binding site [polypeptide binding]; other site 1310115003281 sec-independent translocase; Provisional; Region: PRK03100 1310115003282 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1310115003283 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1310115003284 active site 1310115003285 motif I; other site 1310115003286 motif II; other site 1310115003287 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1310115003288 Predicted membrane protein [Function unknown]; Region: COG3428 1310115003289 Bacterial PH domain; Region: DUF304; pfam03703 1310115003290 Uncharacterized conserved protein [Function unknown]; Region: COG3402 1310115003291 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 1310115003292 Domain of unknown function DUF59; Region: DUF59; cl00941 1310115003293 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1310115003294 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1310115003295 potential frameshift: common BLAST hit: gi|433630333|ref|YP_007263961.1| Conserved membrane protein of unknown function 1310115003296 Predicted membrane protein [Function unknown]; Region: COG4420 1310115003297 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1310115003298 MgtE intracellular N domain; Region: MgtE_N; smart00924 1310115003299 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1310115003300 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1310115003301 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1310115003302 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1310115003303 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1310115003304 dimer interface [polypeptide binding]; other site 1310115003305 conserved gate region; other site 1310115003306 putative PBP binding loops; other site 1310115003307 ABC-ATPase subunit interface; other site 1310115003308 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1310115003309 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1310115003310 dimer interface [polypeptide binding]; other site 1310115003311 conserved gate region; other site 1310115003312 ABC-ATPase subunit interface; other site 1310115003313 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1310115003314 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1310115003315 Walker A/P-loop; other site 1310115003316 ATP binding site [chemical binding]; other site 1310115003317 Q-loop/lid; other site 1310115003318 ABC transporter signature motif; other site 1310115003319 Walker B; other site 1310115003320 D-loop; other site 1310115003321 H-loop/switch region; other site 1310115003322 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1310115003323 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 1310115003324 oligomer interface [polypeptide binding]; other site 1310115003325 metal binding site [ion binding]; metal-binding site 1310115003326 metal binding site [ion binding]; metal-binding site 1310115003327 putative Cl binding site [ion binding]; other site 1310115003328 basic sphincter; other site 1310115003329 hydrophobic gate; other site 1310115003330 periplasmic entrance; other site 1310115003331 malate dehydrogenase; Provisional; Region: PRK05442 1310115003332 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 1310115003333 NAD(P) binding site [chemical binding]; other site 1310115003334 dimer interface [polypeptide binding]; other site 1310115003335 malate binding site [chemical binding]; other site 1310115003336 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1310115003337 PE family; Region: PE; pfam00934 1310115003338 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1310115003339 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1310115003340 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310115003341 NAD(P) binding site [chemical binding]; other site 1310115003342 active site 1310115003343 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1310115003344 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 1310115003345 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 1310115003346 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1310115003347 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1310115003348 TPP-binding site [chemical binding]; other site 1310115003349 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1310115003350 dimer interface [polypeptide binding]; other site 1310115003351 PYR/PP interface [polypeptide binding]; other site 1310115003352 TPP binding site [chemical binding]; other site 1310115003353 potential frameshift: common BLAST hit: gi|397673089|ref|YP_006514624.1| membrane protein 1310115003354 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1310115003355 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310115003356 putative substrate translocation pore; other site 1310115003357 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310115003358 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 1310115003359 RNase_H superfamily; Region: RNase_H_2; pfam13482 1310115003360 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1310115003361 Part of AAA domain; Region: AAA_19; pfam13245 1310115003362 AAA domain; Region: AAA_12; pfam13087 1310115003363 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 1310115003364 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1310115003365 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1310115003366 ATP binding site [chemical binding]; other site 1310115003367 Mg++ binding site [ion binding]; other site 1310115003368 motif III; other site 1310115003369 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1310115003370 nucleotide binding region [chemical binding]; other site 1310115003371 ATP-binding site [chemical binding]; other site 1310115003372 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 1310115003373 putative RNA binding site [nucleotide binding]; other site 1310115003374 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1310115003375 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310115003376 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310115003377 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1310115003378 FAD binding domain; Region: FAD_binding_4; pfam01565 1310115003379 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1310115003380 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310115003381 H+ Antiporter protein; Region: 2A0121; TIGR00900 1310115003382 putative substrate translocation pore; other site 1310115003383 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 1310115003384 Fe-S cluster binding site [ion binding]; other site 1310115003385 DNA binding site [nucleotide binding] 1310115003386 active site 1310115003387 potential frameshift: common BLAST hit: gi|392433146|ref|YP_006474190.1| oxidoreductase 1310115003388 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1310115003389 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1310115003390 HIT family signature motif; other site 1310115003391 catalytic residue [active] 1310115003392 amidase; Provisional; Region: PRK12470 1310115003393 Amidase; Region: Amidase; pfam01425 1310115003394 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1310115003395 cyclase homology domain; Region: CHD; cd07302 1310115003396 nucleotidyl binding site; other site 1310115003397 metal binding site [ion binding]; metal-binding site 1310115003398 dimer interface [polypeptide binding]; other site 1310115003399 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1310115003400 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1310115003401 active site 1310115003402 ATP binding site [chemical binding]; other site 1310115003403 substrate binding site [chemical binding]; other site 1310115003404 activation loop (A-loop); other site 1310115003405 PknH-like extracellular domain; Region: PknH_C; pfam14032 1310115003406 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 1310115003407 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1310115003408 DNA binding site [nucleotide binding] 1310115003409 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1310115003410 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1310115003411 phosphopeptide binding site; other site 1310115003412 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1310115003413 putative active site [active] 1310115003414 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 1310115003415 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 1310115003416 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1310115003417 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1310115003418 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1310115003419 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1310115003420 Walker A/P-loop; other site 1310115003421 ATP binding site [chemical binding]; other site 1310115003422 Q-loop/lid; other site 1310115003423 ABC transporter signature motif; other site 1310115003424 Walker B; other site 1310115003425 D-loop; other site 1310115003426 H-loop/switch region; other site 1310115003427 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1310115003428 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1310115003429 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1310115003430 Walker A/P-loop; other site 1310115003431 ATP binding site [chemical binding]; other site 1310115003432 Q-loop/lid; other site 1310115003433 ABC transporter signature motif; other site 1310115003434 Walker B; other site 1310115003435 D-loop; other site 1310115003436 H-loop/switch region; other site 1310115003437 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1310115003438 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1310115003439 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1310115003440 catalytic core [active] 1310115003441 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1310115003442 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1310115003443 active site 1310115003444 metal binding site [ion binding]; metal-binding site 1310115003445 DNA binding site [nucleotide binding] 1310115003446 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1310115003447 Walker A/P-loop; other site 1310115003448 ATP binding site [chemical binding]; other site 1310115003449 choline dehydrogenase; Validated; Region: PRK02106 1310115003450 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1310115003451 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1310115003452 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1310115003453 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1310115003454 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 1310115003455 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1310115003456 Walker A/P-loop; other site 1310115003457 ATP binding site [chemical binding]; other site 1310115003458 Q-loop/lid; other site 1310115003459 ABC transporter signature motif; other site 1310115003460 Walker B; other site 1310115003461 D-loop; other site 1310115003462 H-loop/switch region; other site 1310115003463 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1310115003464 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1310115003465 Walker A/P-loop; other site 1310115003466 ATP binding site [chemical binding]; other site 1310115003467 Q-loop/lid; other site 1310115003468 ABC transporter signature motif; other site 1310115003469 Walker B; other site 1310115003470 D-loop; other site 1310115003471 H-loop/switch region; other site 1310115003472 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1310115003473 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1310115003474 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1310115003475 dimer interface [polypeptide binding]; other site 1310115003476 conserved gate region; other site 1310115003477 putative PBP binding loops; other site 1310115003478 ABC-ATPase subunit interface; other site 1310115003479 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 1310115003480 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1310115003481 dimer interface [polypeptide binding]; other site 1310115003482 conserved gate region; other site 1310115003483 putative PBP binding loops; other site 1310115003484 ABC-ATPase subunit interface; other site 1310115003485 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1310115003486 active site clefts [active] 1310115003487 zinc binding site [ion binding]; other site 1310115003488 dimer interface [polypeptide binding]; other site 1310115003489 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1310115003490 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1310115003491 Active Sites [active] 1310115003492 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 1310115003493 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1310115003494 CysD dimerization site [polypeptide binding]; other site 1310115003495 G1 box; other site 1310115003496 putative GEF interaction site [polypeptide binding]; other site 1310115003497 GTP/Mg2+ binding site [chemical binding]; other site 1310115003498 Switch I region; other site 1310115003499 G2 box; other site 1310115003500 G3 box; other site 1310115003501 Switch II region; other site 1310115003502 G4 box; other site 1310115003503 G5 box; other site 1310115003504 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1310115003505 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1310115003506 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1310115003507 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1310115003508 Walker A/P-loop; other site 1310115003509 ligand-binding site [chemical binding]; other site 1310115003510 ATP binding site [chemical binding]; other site 1310115003511 Rrf2 family protein; Region: rrf2_super; TIGR00738 1310115003512 Transcriptional regulator; Region: Rrf2; pfam02082 1310115003513 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1310115003514 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1310115003515 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1310115003516 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1310115003517 Putative esterase; Region: Esterase; pfam00756 1310115003518 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1310115003519 Predicted membrane protein [Function unknown]; Region: COG4325 1310115003520 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 1310115003521 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1310115003522 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1310115003523 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1310115003524 active site 1310115003525 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1310115003526 substrate binding site [chemical binding]; other site 1310115003527 catalytic residues [active] 1310115003528 dimer interface [polypeptide binding]; other site 1310115003529 homoserine dehydrogenase; Provisional; Region: PRK06349 1310115003530 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1310115003531 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1310115003532 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1310115003533 threonine synthase; Reviewed; Region: PRK06721 1310115003534 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1310115003535 homodimer interface [polypeptide binding]; other site 1310115003536 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310115003537 catalytic residue [active] 1310115003538 Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083 1310115003539 transcription termination factor Rho; Provisional; Region: PRK12678 1310115003540 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1310115003541 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1310115003542 RNA binding site [nucleotide binding]; other site 1310115003543 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1310115003544 multimer interface [polypeptide binding]; other site 1310115003545 Walker A motif; other site 1310115003546 ATP binding site [chemical binding]; other site 1310115003547 Walker B motif; other site 1310115003548 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1310115003549 peptide chain release factor 1; Region: prfA; TIGR00019 1310115003550 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1310115003551 RF-1 domain; Region: RF-1; pfam00472 1310115003552 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1310115003553 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310115003554 S-adenosylmethionine binding site [chemical binding]; other site 1310115003555 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1310115003556 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1310115003557 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1310115003558 Mg++ binding site [ion binding]; other site 1310115003559 putative catalytic motif [active] 1310115003560 substrate binding site [chemical binding]; other site 1310115003561 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1310115003562 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1310115003563 F0F1 ATP synthase subunit C; Validated; Region: PRK05880 1310115003564 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1310115003565 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1310115003566 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13428 1310115003567 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1310115003568 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 1310115003569 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1310115003570 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1310115003571 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1310115003572 Walker A motif; other site 1310115003573 ATP binding site [chemical binding]; other site 1310115003574 Walker B motif; other site 1310115003575 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1310115003576 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1310115003577 core domain interface [polypeptide binding]; other site 1310115003578 delta subunit interface [polypeptide binding]; other site 1310115003579 epsilon subunit interface [polypeptide binding]; other site 1310115003580 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1310115003581 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1310115003582 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1310115003583 alpha subunit interaction interface [polypeptide binding]; other site 1310115003584 Walker A motif; other site 1310115003585 ATP binding site [chemical binding]; other site 1310115003586 Walker B motif; other site 1310115003587 inhibitor binding site; inhibition site 1310115003588 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1310115003589 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1310115003590 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1310115003591 gamma subunit interface [polypeptide binding]; other site 1310115003592 epsilon subunit interface [polypeptide binding]; other site 1310115003593 LBP interface [polypeptide binding]; other site 1310115003594 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 1310115003595 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1310115003596 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1310115003597 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 1310115003598 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1310115003599 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1310115003600 hinge; other site 1310115003601 active site 1310115003602 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 1310115003603 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1310115003604 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1310115003605 DNA binding site [nucleotide binding] 1310115003606 active site 1310115003607 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1310115003608 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1310115003609 AlkA N-terminal domain; Region: AlkA_N; pfam06029 1310115003610 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1310115003611 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1310115003612 minor groove reading motif; other site 1310115003613 helix-hairpin-helix signature motif; other site 1310115003614 substrate binding pocket [chemical binding]; other site 1310115003615 active site 1310115003616 HAMP domain; Region: HAMP; pfam00672 1310115003617 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1310115003618 cyclase homology domain; Region: CHD; cd07302 1310115003619 nucleotidyl binding site; other site 1310115003620 metal binding site [ion binding]; metal-binding site 1310115003621 dimer interface [polypeptide binding]; other site 1310115003622 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1310115003623 dimerization interface [polypeptide binding]; other site 1310115003624 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1310115003625 cyclase homology domain; Region: CHD; cd07302 1310115003626 nucleotidyl binding site; other site 1310115003627 metal binding site [ion binding]; metal-binding site 1310115003628 dimer interface [polypeptide binding]; other site 1310115003629 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1310115003630 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1310115003631 dimerization interface [polypeptide binding]; other site 1310115003632 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1310115003633 cyclase homology domain; Region: CHD; cd07302 1310115003634 nucleotidyl binding site; other site 1310115003635 metal binding site [ion binding]; metal-binding site 1310115003636 dimer interface [polypeptide binding]; other site 1310115003637 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 1310115003638 hypothetical protein; Provisional; Region: PRK03298 1310115003639 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1310115003640 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1310115003641 dimer interface [polypeptide binding]; other site 1310115003642 substrate binding site [chemical binding]; other site 1310115003643 metal binding site [ion binding]; metal-binding site 1310115003644 putative acyltransferase; Provisional; Region: PRK05790 1310115003645 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1310115003646 dimer interface [polypeptide binding]; other site 1310115003647 active site 1310115003648 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1310115003649 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1310115003650 PE family; Region: PE; pfam00934 1310115003651 glycogen branching enzyme; Provisional; Region: PRK05402 1310115003652 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1310115003653 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1310115003654 active site 1310115003655 catalytic site [active] 1310115003656 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1310115003657 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 1310115003658 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 1310115003659 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1310115003660 active site 1310115003661 homodimer interface [polypeptide binding]; other site 1310115003662 catalytic site [active] 1310115003663 acceptor binding site [chemical binding]; other site 1310115003664 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 1310115003665 putative homodimer interface [polypeptide binding]; other site 1310115003666 putative active site pocket [active] 1310115003667 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 1310115003668 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1310115003669 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1310115003670 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1310115003671 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1310115003672 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1310115003673 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1310115003674 active site 1310115003675 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1310115003676 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 1310115003677 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 1310115003678 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 1310115003679 putative active site pocket [active] 1310115003680 cleavage site 1310115003681 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 1310115003682 MPN+ (JAMM) motif; other site 1310115003683 Zinc-binding site [ion binding]; other site 1310115003684 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1310115003685 MoaE interaction surface [polypeptide binding]; other site 1310115003686 MoeB interaction surface [polypeptide binding]; other site 1310115003687 thiocarboxylated glycine; other site 1310115003688 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1310115003689 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1310115003690 dimer interface [polypeptide binding]; other site 1310115003691 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310115003692 catalytic residue [active] 1310115003693 Rhomboid family; Region: Rhomboid; pfam01694 1310115003694 glutamate racemase; Provisional; Region: PRK00865 1310115003695 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1310115003696 ribonuclease PH; Reviewed; Region: rph; PRK00173 1310115003697 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1310115003698 hexamer interface [polypeptide binding]; other site 1310115003699 active site 1310115003700 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1310115003701 dimerization interface [polypeptide binding]; other site 1310115003702 active site 1310115003703 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1310115003704 Glucitol operon activator [Transcription]; Region: GutM; COG4578 1310115003705 acyl carrier protein; Validated; Region: PRK05883 1310115003706 long-chain-fatty-acid--[acyl-carrier-protein] ligase; Validated; Region: PRK05851 1310115003707 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1310115003708 acyl-activating enzyme (AAE) consensus motif; other site 1310115003709 active site 1310115003710 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1310115003711 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1310115003712 active site 1310115003713 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1310115003714 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1310115003715 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1310115003716 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1310115003717 FAD binding pocket [chemical binding]; other site 1310115003718 FAD binding motif [chemical binding]; other site 1310115003719 phosphate binding motif [ion binding]; other site 1310115003720 NAD binding pocket [chemical binding]; other site 1310115003721 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1310115003722 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1310115003723 Walker A/P-loop; other site 1310115003724 ATP binding site [chemical binding]; other site 1310115003725 Q-loop/lid; other site 1310115003726 ABC transporter signature motif; other site 1310115003727 Walker B; other site 1310115003728 D-loop; other site 1310115003729 H-loop/switch region; other site 1310115003730 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1310115003731 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1310115003732 Walker A/P-loop; other site 1310115003733 ATP binding site [chemical binding]; other site 1310115003734 Q-loop/lid; other site 1310115003735 ABC transporter signature motif; other site 1310115003736 Walker B; other site 1310115003737 D-loop; other site 1310115003738 H-loop/switch region; other site 1310115003739 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1310115003740 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310115003741 NAD(P) binding site [chemical binding]; other site 1310115003742 active site 1310115003743 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1310115003744 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310115003745 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1310115003746 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1310115003747 GAF domain; Region: GAF; pfam01590 1310115003748 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1310115003749 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1310115003750 metal binding site [ion binding]; metal-binding site 1310115003751 active site 1310115003752 I-site; other site 1310115003753 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1310115003754 hypothetical protein; Provisional; Region: PRK07877 1310115003755 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 1310115003756 ATP binding site [chemical binding]; other site 1310115003757 substrate interface [chemical binding]; other site 1310115003758 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1310115003759 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1310115003760 Predicted ATPase [General function prediction only]; Region: COG3903 1310115003761 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1310115003762 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1310115003763 DNA binding residues [nucleotide binding] 1310115003764 dimerization interface [polypeptide binding]; other site 1310115003765 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1310115003766 cyclase homology domain; Region: CHD; cd07302 1310115003767 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 1310115003768 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1310115003769 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115003770 PPE family; Region: PPE; pfam00823 1310115003771 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1310115003772 PAS fold; Region: PAS_4; pfam08448 1310115003773 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1310115003774 putative active site [active] 1310115003775 heme pocket [chemical binding]; other site 1310115003776 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1310115003777 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1310115003778 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1310115003779 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1310115003780 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1310115003781 anti sigma factor interaction site; other site 1310115003782 regulatory phosphorylation site [posttranslational modification]; other site 1310115003783 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1310115003784 anti sigma factor interaction site; other site 1310115003785 regulatory phosphorylation site [posttranslational modification]; other site 1310115003786 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1310115003787 synthetase active site [active] 1310115003788 NTP binding site [chemical binding]; other site 1310115003789 metal binding site [ion binding]; metal-binding site 1310115003790 Beta-lactamase; Region: Beta-lactamase; pfam00144 1310115003791 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1310115003792 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 1310115003793 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; pfam00173 1310115003794 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1310115003795 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1310115003796 putative di-iron ligands [ion binding]; other site 1310115003797 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1310115003798 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1310115003799 malonyl-CoA binding site [chemical binding]; other site 1310115003800 dimer interface [polypeptide binding]; other site 1310115003801 active site 1310115003802 product binding site; other site 1310115003803 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1310115003804 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1310115003805 uncharacterized domain; Region: TIGR00702 1310115003806 YcaO-like family; Region: YcaO; pfam02624 1310115003807 Uncharacterized conserved protein [Function unknown]; Region: COG3482 1310115003808 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310115003809 S-adenosylmethionine binding site [chemical binding]; other site 1310115003810 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1310115003811 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1310115003812 active site 1310115003813 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 1310115003814 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1310115003815 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1310115003816 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1310115003817 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1310115003818 dihydroorotase; Validated; Region: pyrC; PRK09357 1310115003819 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1310115003820 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1310115003821 active site 1310115003822 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1310115003823 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1310115003824 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1310115003825 catalytic site [active] 1310115003826 subunit interface [polypeptide binding]; other site 1310115003827 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1310115003828 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1310115003829 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1310115003830 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1310115003831 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1310115003832 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1310115003833 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1310115003834 IMP binding site; other site 1310115003835 dimer interface [polypeptide binding]; other site 1310115003836 interdomain contacts; other site 1310115003837 partial ornithine binding site; other site 1310115003838 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1310115003839 active site 1310115003840 dimer interface [polypeptide binding]; other site 1310115003841 PE family; Region: PE; pfam00934 1310115003842 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115003843 PPE family; Region: PPE; pfam00823 1310115003844 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1310115003845 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1310115003846 catalytic site [active] 1310115003847 G-X2-G-X-G-K; other site 1310115003848 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 1310115003849 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1310115003850 Flavoprotein; Region: Flavoprotein; pfam02441 1310115003851 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1310115003852 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1310115003853 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1310115003854 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1310115003855 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1310115003856 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1310115003857 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1310115003858 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1310115003859 Cytochrome P450; Region: p450; cl12078 1310115003860 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1310115003861 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1310115003862 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1310115003863 PE family; Region: PE; pfam00934 1310115003864 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1310115003865 oligomeric interface; other site 1310115003866 putative active site [active] 1310115003867 homodimer interface [polypeptide binding]; other site 1310115003868 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1310115003869 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1310115003870 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1310115003871 substrate binding pocket [chemical binding]; other site 1310115003872 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1310115003873 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1310115003874 substrate binding pocket [chemical binding]; other site 1310115003875 Predicted membrane protein [Function unknown]; Region: COG3714 1310115003876 primosome assembly protein PriA; Provisional; Region: PRK14873 1310115003877 primosome assembly protein PriA; Provisional; Region: PRK14873 1310115003878 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310115003879 S-adenosylmethionine binding site [chemical binding]; other site 1310115003880 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1310115003881 MarR family; Region: MarR; pfam01047 1310115003882 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310115003883 S-adenosylmethionine binding site [chemical binding]; other site 1310115003884 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1310115003885 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1310115003886 putative active site [active] 1310115003887 substrate binding site [chemical binding]; other site 1310115003888 putative cosubstrate binding site; other site 1310115003889 catalytic site [active] 1310115003890 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1310115003891 substrate binding site [chemical binding]; other site 1310115003892 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 1310115003893 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 1310115003894 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 1310115003895 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1310115003896 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1310115003897 substrate binding site [chemical binding]; other site 1310115003898 hexamer interface [polypeptide binding]; other site 1310115003899 metal binding site [ion binding]; metal-binding site 1310115003900 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1310115003901 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1310115003902 catalytic motif [active] 1310115003903 Zn binding site [ion binding]; other site 1310115003904 RibD C-terminal domain; Region: RibD_C; pfam01872 1310115003905 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1310115003906 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310115003907 putative substrate translocation pore; other site 1310115003908 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 1310115003909 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1310115003910 Lumazine binding domain; Region: Lum_binding; pfam00677 1310115003911 Lumazine binding domain; Region: Lum_binding; pfam00677 1310115003912 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1310115003913 catalytic residue [active] 1310115003914 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1310115003915 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1310115003916 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1310115003917 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1310115003918 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1310115003919 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1310115003920 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1310115003921 dimerization interface [polypeptide binding]; other site 1310115003922 active site 1310115003923 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1310115003924 homopentamer interface [polypeptide binding]; other site 1310115003925 active site 1310115003926 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1310115003927 PknH-like extracellular domain; Region: PknH_C; pfam14032 1310115003928 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1310115003929 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1310115003930 putative sugar binding sites [chemical binding]; other site 1310115003931 Q-X-W motif; other site 1310115003932 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1310115003933 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1310115003934 GIY-YIG motif/motif A; other site 1310115003935 active site 1310115003936 catalytic site [active] 1310115003937 putative DNA binding site [nucleotide binding]; other site 1310115003938 metal binding site [ion binding]; metal-binding site 1310115003939 UvrB/uvrC motif; Region: UVR; pfam02151 1310115003940 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1310115003941 Helix-hairpin-helix motif; Region: HHH; pfam00633 1310115003942 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 1310115003943 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1310115003944 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1310115003945 phosphate binding site [ion binding]; other site 1310115003946 putative substrate binding pocket [chemical binding]; other site 1310115003947 dimer interface [polypeptide binding]; other site 1310115003948 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1310115003949 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1310115003950 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1310115003951 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1310115003952 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1310115003953 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1310115003954 acyl-CoA synthetase; Provisional; Region: PRK13382 1310115003955 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1310115003956 acyl-activating enzyme (AAE) consensus motif; other site 1310115003957 putative AMP binding site [chemical binding]; other site 1310115003958 putative active site [active] 1310115003959 putative CoA binding site [chemical binding]; other site 1310115003960 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1310115003961 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1310115003962 putative acyl-acceptor binding pocket; other site 1310115003963 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1310115003964 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1310115003965 PE family; Region: PE; pfam00934 1310115003966 PE-PPE domain; Region: PE-PPE; pfam08237 1310115003967 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 1310115003968 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1310115003969 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1310115003970 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1310115003971 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1310115003972 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1310115003973 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1310115003974 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1310115003975 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1310115003976 Phosphoglycerate kinase; Region: PGK; pfam00162 1310115003977 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1310115003978 substrate binding site [chemical binding]; other site 1310115003979 hinge regions; other site 1310115003980 ADP binding site [chemical binding]; other site 1310115003981 catalytic site [active] 1310115003982 triosephosphate isomerase; Provisional; Region: PRK14567 1310115003983 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1310115003984 substrate binding site [chemical binding]; other site 1310115003985 dimer interface [polypeptide binding]; other site 1310115003986 catalytic triad [active] 1310115003987 SnoaL-like domain; Region: SnoaL_2; pfam12680 1310115003988 Preprotein translocase SecG subunit; Region: SecG; cl09123 1310115003989 PE family; Region: PE; pfam00934 1310115003990 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 1310115003991 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 1310115003992 molybdopterin cofactor binding site [chemical binding]; other site 1310115003993 substrate binding site [chemical binding]; other site 1310115003994 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 1310115003995 molybdopterin cofactor binding site; other site 1310115003996 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1310115003997 hydrophobic ligand binding site; other site 1310115003998 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1310115003999 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1310115004000 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1310115004001 putative active site [active] 1310115004002 potential frameshift: common BLAST hit: gi|397673294|ref|YP_006514829.1| opcA protein 1310115004003 potential frameshift: common BLAST hit: gi|471337370|ref|YP_007610083.1| glucose-6-phosphate 1-dehydrogenase 1310115004004 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 1310115004005 putative active site [active] 1310115004006 transaldolase; Provisional; Region: PRK03903 1310115004007 catalytic residue [active] 1310115004008 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1310115004009 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1310115004010 TPP-binding site [chemical binding]; other site 1310115004011 dimer interface [polypeptide binding]; other site 1310115004012 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1310115004013 PYR/PP interface [polypeptide binding]; other site 1310115004014 dimer interface [polypeptide binding]; other site 1310115004015 TPP binding site [chemical binding]; other site 1310115004016 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1310115004017 UbiA prenyltransferase family; Region: UbiA; pfam01040 1310115004018 PE family; Region: PE; pfam00934 1310115004019 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1310115004020 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1310115004021 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1310115004022 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1310115004023 NADP binding site [chemical binding]; other site 1310115004024 dimer interface [polypeptide binding]; other site 1310115004025 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1310115004026 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1310115004027 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 1310115004028 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1310115004029 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1310115004030 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1310115004031 Walker A/P-loop; other site 1310115004032 ATP binding site [chemical binding]; other site 1310115004033 Q-loop/lid; other site 1310115004034 ABC transporter signature motif; other site 1310115004035 Walker B; other site 1310115004036 D-loop; other site 1310115004037 H-loop/switch region; other site 1310115004038 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1310115004039 Predicted transcriptional regulator [Transcription]; Region: COG2345 1310115004040 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1310115004041 putative DNA binding site [nucleotide binding]; other site 1310115004042 putative Zn2+ binding site [ion binding]; other site 1310115004043 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1310115004044 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1310115004045 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1310115004046 protein-splicing catalytic site; other site 1310115004047 thioester formation/cholesterol transfer; other site 1310115004048 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 1310115004049 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 1310115004050 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1310115004051 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1310115004052 FeS assembly protein SufD; Region: sufD; TIGR01981 1310115004053 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1310115004054 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1310115004055 Walker A/P-loop; other site 1310115004056 ATP binding site [chemical binding]; other site 1310115004057 Q-loop/lid; other site 1310115004058 ABC transporter signature motif; other site 1310115004059 Walker B; other site 1310115004060 D-loop; other site 1310115004061 H-loop/switch region; other site 1310115004062 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1310115004063 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1310115004064 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1310115004065 catalytic residue [active] 1310115004066 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1310115004067 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1310115004068 trimerization site [polypeptide binding]; other site 1310115004069 active site 1310115004070 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1310115004071 potential frameshift: common BLAST hit: gi|471337393|ref|YP_007610106.1| acyl-CoA dehydrogenase 1310115004072 PE family; Region: PE; pfam00934 1310115004073 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1310115004074 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1310115004075 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1310115004076 catalytic residues [active] 1310115004077 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1310115004078 catalytic residues [active] 1310115004079 enoyl-CoA hydratase; Provisional; Region: PRK05864 1310115004080 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1310115004081 substrate binding site [chemical binding]; other site 1310115004082 oxyanion hole (OAH) forming residues; other site 1310115004083 trimer interface [polypeptide binding]; other site 1310115004084 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1310115004085 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1310115004086 Walker A/P-loop; other site 1310115004087 ATP binding site [chemical binding]; other site 1310115004088 Q-loop/lid; other site 1310115004089 ABC transporter signature motif; other site 1310115004090 Walker B; other site 1310115004091 D-loop; other site 1310115004092 H-loop/switch region; other site 1310115004093 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1310115004094 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310115004095 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310115004096 aconitate hydratase; Validated; Region: PRK09277 1310115004097 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1310115004098 substrate binding site [chemical binding]; other site 1310115004099 ligand binding site [chemical binding]; other site 1310115004100 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1310115004101 substrate binding site [chemical binding]; other site 1310115004102 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1310115004103 NlpC/P60 family; Region: NLPC_P60; pfam00877 1310115004104 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1310115004105 NlpC/P60 family; Region: NLPC_P60; pfam00877 1310115004106 MoxR-like ATPases [General function prediction only]; Region: COG0714 1310115004107 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1310115004108 Walker A motif; other site 1310115004109 ATP binding site [chemical binding]; other site 1310115004110 Walker B motif; other site 1310115004111 arginine finger; other site 1310115004112 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1310115004113 hypothetical protein; Provisional; Region: PRK13685 1310115004114 hypothetical protein; Provisional; Region: PRK13685 1310115004115 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1310115004116 metal ion-dependent adhesion site (MIDAS); other site 1310115004117 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1310115004118 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1310115004119 NAD(P) binding site [chemical binding]; other site 1310115004120 homotetramer interface [polypeptide binding]; other site 1310115004121 homodimer interface [polypeptide binding]; other site 1310115004122 active site 1310115004123 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 1310115004124 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1310115004125 NAD binding site [chemical binding]; other site 1310115004126 homotetramer interface [polypeptide binding]; other site 1310115004127 homodimer interface [polypeptide binding]; other site 1310115004128 substrate binding site [chemical binding]; other site 1310115004129 active site 1310115004130 ferrochelatase; Reviewed; Region: hemH; PRK00035 1310115004131 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1310115004132 C-terminal domain interface [polypeptide binding]; other site 1310115004133 active site 1310115004134 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1310115004135 active site 1310115004136 N-terminal domain interface [polypeptide binding]; other site 1310115004137 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 1310115004138 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1310115004139 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1310115004140 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 1310115004141 Transposase domain (DUF772); Region: DUF772; pfam05598 1310115004142 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1310115004143 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1310115004144 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 1310115004145 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 1310115004146 heterodimer interface [polypeptide binding]; other site 1310115004147 substrate interaction site [chemical binding]; other site 1310115004148 Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding) [Lipid metabolism]; Region: Sbm; COG2185 1310115004149 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 1310115004150 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 1310115004151 active site 1310115004152 substrate binding site [chemical binding]; other site 1310115004153 coenzyme B12 binding site [chemical binding]; other site 1310115004154 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1310115004155 B12 binding site [chemical binding]; other site 1310115004156 cobalt ligand [ion binding]; other site 1310115004157 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1310115004158 membrane ATPase/protein kinase; Provisional; Region: PRK09435 1310115004159 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 1310115004160 Walker A; other site 1310115004161 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1310115004162 Beta-lactamase; Region: Beta-lactamase; pfam00144 1310115004163 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1310115004164 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310115004165 S-adenosylmethionine binding site [chemical binding]; other site 1310115004166 Uncharacterized conserved protein [Function unknown]; Region: COG3360 1310115004167 NUDIX domain; Region: NUDIX; pfam00293 1310115004168 nudix motif; other site 1310115004169 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1310115004170 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1310115004171 Ligand binding site; other site 1310115004172 Putative Catalytic site; other site 1310115004173 DXD motif; other site 1310115004174 Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5285 1310115004175 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 1310115004176 active site 1310115004177 potential frameshift: common BLAST hit: gi|433641656|ref|YP_007287415.1| Lipopolysaccharide biosynthesis protein RffA 1310115004178 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 1310115004179 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 1310115004180 putative trimer interface [polypeptide binding]; other site 1310115004181 putative CoA binding site [chemical binding]; other site 1310115004182 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1310115004183 S-adenosylmethionine binding site [chemical binding]; other site 1310115004184 WbqC-like protein family; Region: WbqC; pfam08889 1310115004185 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1310115004186 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310115004187 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310115004188 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1310115004189 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1310115004190 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1310115004191 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1310115004192 NADP-binding site; other site 1310115004193 homotetramer interface [polypeptide binding]; other site 1310115004194 substrate binding site [chemical binding]; other site 1310115004195 homodimer interface [polypeptide binding]; other site 1310115004196 active site 1310115004197 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 1310115004198 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 1310115004199 NADP binding site [chemical binding]; other site 1310115004200 active site 1310115004201 putative substrate binding site [chemical binding]; other site 1310115004202 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1310115004203 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 1310115004204 metal-binding site 1310115004205 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310115004206 S-adenosylmethionine binding site [chemical binding]; other site 1310115004207 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1310115004208 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1310115004209 active site 1310115004210 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1310115004211 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1310115004212 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1310115004213 active site 1310115004214 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 1310115004215 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1310115004216 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1310115004217 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1310115004218 active site 1310115004219 acyl-CoA synthetase; Validated; Region: PRK05850 1310115004220 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1310115004221 acyl-activating enzyme (AAE) consensus motif; other site 1310115004222 active site 1310115004223 Transport protein; Region: actII; TIGR00833 1310115004224 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1310115004225 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310115004226 S-adenosylmethionine binding site [chemical binding]; other site 1310115004227 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1310115004228 active site 1310115004229 TDP-binding site; other site 1310115004230 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1310115004231 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1310115004232 Probable Catalytic site; other site 1310115004233 metal-binding site 1310115004234 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1310115004235 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1310115004236 homodimer interface [polypeptide binding]; other site 1310115004237 active site 1310115004238 TDP-binding site; other site 1310115004239 acceptor substrate-binding pocket; other site 1310115004240 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1310115004241 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1310115004242 active site 1310115004243 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 1310115004244 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1310115004245 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310115004246 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1310115004247 Enoylreductase; Region: PKS_ER; smart00829 1310115004248 NAD(P) binding site [chemical binding]; other site 1310115004249 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1310115004250 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1310115004251 putative NADP binding site [chemical binding]; other site 1310115004252 active site 1310115004253 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1310115004254 acyl-CoA synthetase; Validated; Region: PRK05850 1310115004255 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1310115004256 acyl-activating enzyme (AAE) consensus motif; other site 1310115004257 active site 1310115004258 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1310115004259 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1310115004260 NAD(P) binding site [chemical binding]; other site 1310115004261 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1310115004262 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1310115004263 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1310115004264 CoenzymeA binding site [chemical binding]; other site 1310115004265 subunit interaction site [polypeptide binding]; other site 1310115004266 PHB binding site; other site 1310115004267 Nitronate monooxygenase; Region: NMO; pfam03060 1310115004268 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1310115004269 FMN binding site [chemical binding]; other site 1310115004270 substrate binding site [chemical binding]; other site 1310115004271 putative catalytic residue [active] 1310115004272 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310115004273 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 1310115004274 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1310115004275 HIGH motif; other site 1310115004276 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1310115004277 active site 1310115004278 KMSKS motif; other site 1310115004279 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1310115004280 tRNA binding surface [nucleotide binding]; other site 1310115004281 anticodon binding site; other site 1310115004282 DNA polymerase IV; Provisional; Region: PRK03348 1310115004283 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1310115004284 active site 1310115004285 DNA binding site [nucleotide binding] 1310115004286 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1310115004287 active site 1310115004288 homodimer interface [polypeptide binding]; other site 1310115004289 homotetramer interface [polypeptide binding]; other site 1310115004290 lipoprotein signal peptidase; Provisional; Region: PRK14764 1310115004291 lipoprotein signal peptidase; Provisional; Region: PRK14787 1310115004292 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1310115004293 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1310115004294 active site 1310115004295 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 1310115004296 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1310115004297 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 1310115004298 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1310115004299 apolar tunnel; other site 1310115004300 heme binding site [chemical binding]; other site 1310115004301 dimerization interface [polypeptide binding]; other site 1310115004302 short chain dehydrogenase; Provisional; Region: PRK05866 1310115004303 classical (c) SDRs; Region: SDR_c; cd05233 1310115004304 NAD(P) binding site [chemical binding]; other site 1310115004305 active site 1310115004306 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1310115004307 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310115004308 NAD(P) binding site [chemical binding]; other site 1310115004309 active site 1310115004310 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1310115004311 hydrophobic ligand binding site; other site 1310115004312 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1310115004313 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1310115004314 active site 1310115004315 PHP Thumb interface [polypeptide binding]; other site 1310115004316 metal binding site [ion binding]; metal-binding site 1310115004317 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1310115004318 generic binding surface II; other site 1310115004319 generic binding surface I; other site 1310115004320 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310115004321 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310115004322 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115004323 PPE family; Region: PPE; pfam00823 1310115004324 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1310115004325 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1310115004326 acyl-activating enzyme (AAE) consensus motif; other site 1310115004327 putative AMP binding site [chemical binding]; other site 1310115004328 putative active site [active] 1310115004329 putative CoA binding site [chemical binding]; other site 1310115004330 glycerol-3-phosphate acyltransferase; Reviewed; Region: PRK11915 1310115004331 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1310115004332 putative acyl-acceptor binding pocket; other site 1310115004333 fumarate reductase, flavoprotein subunit; Region: fum_red_Fp; TIGR01176 1310115004334 L-aspartate oxidase; Provisional; Region: PRK06175 1310115004335 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1310115004336 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 1310115004337 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1310115004338 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 1310115004339 D-subunit interface [polypeptide binding]; other site 1310115004340 Iron-sulfur protein interface; other site 1310115004341 proximal quinone binding site [chemical binding]; other site 1310115004342 distal quinone binding site [chemical binding]; other site 1310115004343 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 1310115004344 Iron-sulfur protein interface; other site 1310115004345 proximal quinone binding site [chemical binding]; other site 1310115004346 C-subunit interface; other site 1310115004347 distal quinone binding site; other site 1310115004348 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310115004349 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310115004350 MMPL family; Region: MMPL; pfam03176 1310115004351 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1310115004352 threonine dehydratase; Validated; Region: PRK08639 1310115004353 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1310115004354 tetramer interface [polypeptide binding]; other site 1310115004355 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310115004356 catalytic residue [active] 1310115004357 C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585 1310115004358 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1310115004359 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1310115004360 putative active site [active] 1310115004361 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1310115004362 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 1310115004363 catalytic site [active] 1310115004364 active site 1310115004365 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1310115004366 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 1310115004367 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 1310115004368 active site 1310115004369 catalytic site [active] 1310115004370 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1310115004371 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1310115004372 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1310115004373 active site 1310115004374 catalytic site [active] 1310115004375 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1310115004376 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1310115004377 NlpC/P60 family; Region: NLPC_P60; pfam00877 1310115004378 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 1310115004379 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1310115004380 inhibitor-cofactor binding pocket; inhibition site 1310115004381 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310115004382 catalytic residue [active] 1310115004383 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 1310115004384 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 1310115004385 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1310115004386 catalytic residue [active] 1310115004387 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1310115004388 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 1310115004389 potential frameshift: common BLAST hit: gi|31792762|ref|NP_855255.1| phiRV1 phage protein 1310115004390 Phage head maturation protease [General function prediction only]; Region: COG3740 1310115004391 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: COG3747 1310115004392 Phage associated DNA primase [General function prediction only]; Region: COG3378 1310115004393 D5 N terminal like; Region: D5_N; smart00885 1310115004394 Protein of unknown function (DUF2742); Region: DUF2742; pfam10888 1310115004395 Recombinase; Region: Recombinase; pfam07508 1310115004396 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1310115004397 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1310115004398 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1310115004399 active site 1310115004400 biotin synthase; Validated; Region: PRK06256 1310115004401 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1310115004402 FeS/SAM binding site; other site 1310115004403 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1310115004404 Protein of unknown function (DUF2567); Region: DUF2567; pfam10821 1310115004405 Secretory lipase; Region: LIP; pfam03583 1310115004406 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 1310115004407 nudix motif; other site 1310115004408 quinolinate synthetase; Provisional; Region: PRK09375 1310115004409 L-aspartate oxidase; Provisional; Region: PRK07804 1310115004410 L-aspartate oxidase; Provisional; Region: PRK06175 1310115004411 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1310115004412 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 1310115004413 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1310115004414 dimerization interface [polypeptide binding]; other site 1310115004415 active site 1310115004416 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310115004417 S-adenosylmethionine binding site [chemical binding]; other site 1310115004418 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 1310115004419 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 1310115004420 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1310115004421 NAD binding site [chemical binding]; other site 1310115004422 dimerization interface [polypeptide binding]; other site 1310115004423 product binding site; other site 1310115004424 substrate binding site [chemical binding]; other site 1310115004425 zinc binding site [ion binding]; other site 1310115004426 catalytic residues [active] 1310115004427 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 1310115004428 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1310115004429 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310115004430 homodimer interface [polypeptide binding]; other site 1310115004431 catalytic residue [active] 1310115004432 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1310115004433 4-fold oligomerization interface [polypeptide binding]; other site 1310115004434 putative active site pocket [active] 1310115004435 metal binding residues [ion binding]; metal-binding site 1310115004436 3-fold/trimer interface [polypeptide binding]; other site 1310115004437 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1310115004438 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1310115004439 putative active site [active] 1310115004440 oxyanion strand; other site 1310115004441 catalytic triad [active] 1310115004442 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1310115004443 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1310115004444 catalytic residues [active] 1310115004445 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1310115004446 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1310115004447 active site 1310115004448 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1310115004449 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1310115004450 substrate binding site [chemical binding]; other site 1310115004451 glutamase interaction surface [polypeptide binding]; other site 1310115004452 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1310115004453 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 1310115004454 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1310115004455 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1310115004456 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1310115004457 catalytic triad [active] 1310115004458 anthranilate synthase component I; Provisional; Region: PRK13571 1310115004459 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1310115004460 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1310115004461 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 1310115004462 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1310115004463 active site 1310115004464 ribulose/triose binding site [chemical binding]; other site 1310115004465 phosphate binding site [ion binding]; other site 1310115004466 substrate (anthranilate) binding pocket [chemical binding]; other site 1310115004467 product (indole) binding pocket [chemical binding]; other site 1310115004468 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1310115004469 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1310115004470 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310115004471 catalytic residue [active] 1310115004472 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1310115004473 substrate binding site [chemical binding]; other site 1310115004474 active site 1310115004475 catalytic residues [active] 1310115004476 heterodimer interface [polypeptide binding]; other site 1310115004477 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108 1310115004478 Prolipoprotein diacylglyceryltransferase [Cell envelope biogenesis, outer membrane]; Region: Lgt; COG0682 1310115004479 TM2 domain; Region: TM2; pfam05154 1310115004480 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 1310115004481 pyruvate kinase; Provisional; Region: PRK06247 1310115004482 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1310115004483 domain interfaces; other site 1310115004484 active site 1310115004485 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1310115004486 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1310115004487 active site 1310115004488 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1310115004489 catalytic triad [active] 1310115004490 dimer interface [polypeptide binding]; other site 1310115004491 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1310115004492 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1310115004493 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 1310115004494 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1310115004495 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1310115004496 Walker A/P-loop; other site 1310115004497 Walker A/P-loop; other site 1310115004498 ATP binding site [chemical binding]; other site 1310115004499 ATP binding site [chemical binding]; other site 1310115004500 Q-loop/lid; other site 1310115004501 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1310115004502 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1310115004503 Walker A/P-loop; other site 1310115004504 ATP binding site [chemical binding]; other site 1310115004505 Q-loop/lid; other site 1310115004506 ABC transporter signature motif; other site 1310115004507 Walker B; other site 1310115004508 D-loop; other site 1310115004509 H-loop/switch region; other site 1310115004510 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1310115004511 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1310115004512 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1310115004513 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1310115004514 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 1310115004515 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1310115004516 cyclase homology domain; Region: CHD; cd07302 1310115004517 nucleotidyl binding site; other site 1310115004518 metal binding site [ion binding]; metal-binding site 1310115004519 dimer interface [polypeptide binding]; other site 1310115004520 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1310115004521 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1310115004522 active site 1310115004523 phosphorylation site [posttranslational modification] 1310115004524 intermolecular recognition site; other site 1310115004525 dimerization interface [polypeptide binding]; other site 1310115004526 ANTAR domain; Region: ANTAR; pfam03861 1310115004527 lipid-transfer protein; Provisional; Region: PRK06059 1310115004528 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1310115004529 active site 1310115004530 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1310115004531 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1310115004532 DUF35 OB-fold domain; Region: DUF35; pfam01796 1310115004533 DNA polymerase I; Provisional; Region: PRK05755 1310115004534 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1310115004535 active site 1310115004536 metal binding site 1 [ion binding]; metal-binding site 1310115004537 putative 5' ssDNA interaction site; other site 1310115004538 metal binding site 3; metal-binding site 1310115004539 metal binding site 2 [ion binding]; metal-binding site 1310115004540 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1310115004541 putative DNA binding site [nucleotide binding]; other site 1310115004542 putative metal binding site [ion binding]; other site 1310115004543 3'-5' exonuclease; Region: 35EXOc; smart00474 1310115004544 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1310115004545 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1310115004546 active site 1310115004547 DNA binding site [nucleotide binding] 1310115004548 catalytic site [active] 1310115004549 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 1310115004550 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1310115004551 RNA binding site [nucleotide binding]; other site 1310115004552 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1310115004553 RNA binding site [nucleotide binding]; other site 1310115004554 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1310115004555 RNA binding site [nucleotide binding]; other site 1310115004556 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1310115004557 RNA binding site [nucleotide binding]; other site 1310115004558 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 1310115004559 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1310115004560 CoA-binding site [chemical binding]; other site 1310115004561 ATP-binding [chemical binding]; other site 1310115004562 Uncharacterized conserved protein [Function unknown]; Region: GrpB; COG2320 1310115004563 Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306 1310115004564 excinuclease ABC subunit B; Provisional; Region: PRK05298 1310115004565 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1310115004566 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1310115004567 nucleotide binding region [chemical binding]; other site 1310115004568 ATP-binding site [chemical binding]; other site 1310115004569 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1310115004570 UvrB/uvrC motif; Region: UVR; pfam02151 1310115004571 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310115004572 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1310115004573 putative substrate translocation pore; other site 1310115004574 Predicted membrane protein [Function unknown]; Region: COG5305 1310115004575 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1310115004576 Ligand Binding Site [chemical binding]; other site 1310115004577 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1310115004578 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1310115004579 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1310115004580 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1310115004581 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1310115004582 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1310115004583 Predicted esterase [General function prediction only]; Region: COG0627 1310115004584 potential frameshift: common BLAST hit: gi|392432777|ref|YP_006473821.1| lysyl-tRNA synthetase 2 lysX 1310115004585 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1310115004586 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1310115004587 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1310115004588 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1310115004589 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1310115004590 23S rRNA binding site [nucleotide binding]; other site 1310115004591 L21 binding site [polypeptide binding]; other site 1310115004592 L13 binding site [polypeptide binding]; other site 1310115004593 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1310115004594 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1310115004595 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 1310115004596 PE family; Region: PE; pfam00934 1310115004597 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1310115004598 cyclase homology domain; Region: CHD; cd07302 1310115004599 nucleotidyl binding site; other site 1310115004600 metal binding site [ion binding]; metal-binding site 1310115004601 dimer interface [polypeptide binding]; other site 1310115004602 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1310115004603 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1310115004604 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1310115004605 dimer interface [polypeptide binding]; other site 1310115004606 motif 1; other site 1310115004607 active site 1310115004608 motif 2; other site 1310115004609 motif 3; other site 1310115004610 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1310115004611 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1310115004612 putative tRNA-binding site [nucleotide binding]; other site 1310115004613 B3/4 domain; Region: B3_4; pfam03483 1310115004614 tRNA synthetase B5 domain; Region: B5; smart00874 1310115004615 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1310115004616 dimer interface [polypeptide binding]; other site 1310115004617 motif 1; other site 1310115004618 motif 3; other site 1310115004619 motif 2; other site 1310115004620 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1310115004621 PE family; Region: PE; pfam00934 1310115004622 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 1310115004623 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1310115004624 potential frameshift: common BLAST hit: gi|471337578|ref|YP_007610291.1| bifunctional ornithineacetyltransferase/N-acetylglutamate synthase 1310115004625 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1310115004626 feedback inhibition sensing region; other site 1310115004627 homohexameric interface [polypeptide binding]; other site 1310115004628 nucleotide binding site [chemical binding]; other site 1310115004629 N-acetyl-L-glutamate binding site [chemical binding]; other site 1310115004630 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 1310115004631 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1310115004632 inhibitor-cofactor binding pocket; inhibition site 1310115004633 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310115004634 catalytic residue [active] 1310115004635 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1310115004636 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1310115004637 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1310115004638 arginine repressor; Provisional; Region: PRK03341 1310115004639 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1310115004640 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1310115004641 argininosuccinate synthase; Provisional; Region: PRK13820 1310115004642 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1310115004643 ANP binding site [chemical binding]; other site 1310115004644 Substrate Binding Site II [chemical binding]; other site 1310115004645 Substrate Binding Site I [chemical binding]; other site 1310115004646 argininosuccinate lyase; Provisional; Region: PRK00855 1310115004647 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1310115004648 active sites [active] 1310115004649 tetramer interface [polypeptide binding]; other site 1310115004650 potential frameshift: common BLAST hit: gi|471337585|ref|YP_007610298.1| chalcone synthase 1310115004651 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1310115004652 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1310115004653 active site 1310115004654 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1310115004655 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1310115004656 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1310115004657 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310115004658 Enoylreductase; Region: PKS_ER; smart00829 1310115004659 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1310115004660 NAD(P) binding site [chemical binding]; other site 1310115004661 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1310115004662 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1310115004663 putative NADP binding site [chemical binding]; other site 1310115004664 active site 1310115004665 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1310115004666 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1310115004667 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1310115004668 active site 1310115004669 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1310115004670 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1310115004671 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310115004672 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1310115004673 Enoylreductase; Region: PKS_ER; smart00829 1310115004674 NAD(P) binding site [chemical binding]; other site 1310115004675 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1310115004676 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1310115004677 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1310115004678 putative NADP binding site [chemical binding]; other site 1310115004679 active site 1310115004680 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1310115004681 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1310115004682 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1310115004683 active site 1310115004684 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1310115004685 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1310115004686 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1310115004687 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1310115004688 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1310115004689 malonyl-CoA binding site [chemical binding]; other site 1310115004690 dimer interface [polypeptide binding]; other site 1310115004691 active site 1310115004692 product binding site; other site 1310115004693 Cytochrome P450; Region: p450; cl12078 1310115004694 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1310115004695 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1310115004696 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1310115004697 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1310115004698 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1310115004699 ABC transporter; Region: ABC_tran_2; pfam12848 1310115004700 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1310115004701 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 1310115004702 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310115004703 putative substrate translocation pore; other site 1310115004704 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1310115004705 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1310115004706 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1310115004707 dimerization interface [polypeptide binding]; other site 1310115004708 putative DNA binding site [nucleotide binding]; other site 1310115004709 putative Zn2+ binding site [ion binding]; other site 1310115004710 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1310115004711 active site residue [active] 1310115004712 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1310115004713 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1310115004714 ligand binding site [chemical binding]; other site 1310115004715 flexible hinge region; other site 1310115004716 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1310115004717 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 1310115004718 putative catalytic residues [active] 1310115004719 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 1310115004720 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1310115004721 catalytic residues [active] 1310115004722 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1310115004723 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1310115004724 active site 1310115004725 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 1310115004726 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1310115004727 substrate binding pocket [chemical binding]; other site 1310115004728 membrane-bound complex binding site; other site 1310115004729 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 1310115004730 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1310115004731 FeS/SAM binding site; other site 1310115004732 DivIVA protein; Region: DivIVA; pfam05103 1310115004733 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1310115004734 acyl-CoA synthetase; Validated; Region: PRK07868 1310115004735 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 1310115004736 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1310115004737 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1310115004738 acyl-activating enzyme (AAE) consensus motif; other site 1310115004739 active site 1310115004740 AMP binding site [chemical binding]; other site 1310115004741 CoA binding site [chemical binding]; other site 1310115004742 Uncharacterized conserved protein [Function unknown]; Region: COG2835 1310115004743 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310115004744 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310115004745 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 1310115004746 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1310115004747 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1310115004748 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 1310115004749 Walker A/P-loop; other site 1310115004750 ATP binding site [chemical binding]; other site 1310115004751 Q-loop/lid; other site 1310115004752 ABC transporter signature motif; other site 1310115004753 Walker B; other site 1310115004754 D-loop; other site 1310115004755 H-loop/switch region; other site 1310115004756 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1310115004757 active site 1310115004758 DNA binding site [nucleotide binding] 1310115004759 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1310115004760 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1310115004761 active site 1310115004762 HIGH motif; other site 1310115004763 dimer interface [polypeptide binding]; other site 1310115004764 KMSKS motif; other site 1310115004765 S4 RNA-binding domain; Region: S4; smart00363 1310115004766 RNA binding surface [nucleotide binding]; other site 1310115004767 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1310115004768 Tetratrico peptide repeat; Region: TPR_5; pfam12688 1310115004769 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1310115004770 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 1310115004771 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1310115004772 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1310115004773 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310115004774 S-adenosylmethionine binding site [chemical binding]; other site 1310115004775 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 1310115004776 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1310115004777 DNA repair protein RecN; Region: recN; TIGR00634 1310115004778 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1310115004779 Walker A/P-loop; other site 1310115004780 ATP binding site [chemical binding]; other site 1310115004781 Q-loop/lid; other site 1310115004782 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1310115004783 ABC transporter signature motif; other site 1310115004784 Walker B; other site 1310115004785 D-loop; other site 1310115004786 H-loop/switch region; other site 1310115004787 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 1310115004788 Thiamine pyrophosphokinase; Region: TPK; cl08415 1310115004789 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 1310115004790 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 1310115004791 CTP synthetase; Validated; Region: pyrG; PRK05380 1310115004792 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1310115004793 Catalytic site [active] 1310115004794 active site 1310115004795 UTP binding site [chemical binding]; other site 1310115004796 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1310115004797 active site 1310115004798 putative oxyanion hole; other site 1310115004799 catalytic triad [active] 1310115004800 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1310115004801 dimer interface [polypeptide binding]; other site 1310115004802 ADP-ribose binding site [chemical binding]; other site 1310115004803 active site 1310115004804 nudix motif; other site 1310115004805 metal binding site [ion binding]; metal-binding site 1310115004806 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1310115004807 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1310115004808 active site 1310115004809 DNA binding site [nucleotide binding] 1310115004810 Int/Topo IB signature motif; other site 1310115004811 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1310115004812 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1310115004813 active site 1310115004814 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1310115004815 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310115004816 S-adenosylmethionine binding site [chemical binding]; other site 1310115004817 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 1310115004818 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115004819 PPE family; Region: PPE; pfam00823 1310115004820 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1310115004821 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115004822 PPE family; Region: PPE; pfam00823 1310115004823 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1310115004824 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1310115004825 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1310115004826 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1310115004827 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1310115004828 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1310115004829 P-loop; other site 1310115004830 Magnesium ion binding site [ion binding]; other site 1310115004831 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1310115004832 Magnesium ion binding site [ion binding]; other site 1310115004833 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 1310115004834 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 1310115004835 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1310115004836 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1310115004837 RNA binding surface [nucleotide binding]; other site 1310115004838 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1310115004839 active site 1310115004840 cytidylate kinase; Provisional; Region: cmk; PRK00023 1310115004841 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1310115004842 CMP-binding site; other site 1310115004843 The sites determining sugar specificity; other site 1310115004844 GTP-binding protein Der; Reviewed; Region: PRK03003 1310115004845 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1310115004846 GTP/Mg2+ binding site [chemical binding]; other site 1310115004847 Switch I region; other site 1310115004848 G2 box; other site 1310115004849 Switch II region; other site 1310115004850 G3 box; other site 1310115004851 G4 box; other site 1310115004852 G5 box; other site 1310115004853 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1310115004854 G1 box; other site 1310115004855 GTP/Mg2+ binding site [chemical binding]; other site 1310115004856 Switch I region; other site 1310115004857 G2 box; other site 1310115004858 G3 box; other site 1310115004859 Switch II region; other site 1310115004860 G4 box; other site 1310115004861 G5 box; other site 1310115004862 short chain dehydrogenase; Provisional; Region: PRK07060 1310115004863 classical (c) SDRs; Region: SDR_c; cd05233 1310115004864 NAD(P) binding site [chemical binding]; other site 1310115004865 active site 1310115004866 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1310115004867 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1310115004868 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1310115004869 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1310115004870 Cupin domain; Region: Cupin_2; pfam07883 1310115004871 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 1310115004872 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1310115004873 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1310115004874 putative switch regulator; other site 1310115004875 non-specific DNA interactions [nucleotide binding]; other site 1310115004876 DNA binding site [nucleotide binding] 1310115004877 sequence specific DNA binding site [nucleotide binding]; other site 1310115004878 putative cAMP binding site [chemical binding]; other site 1310115004879 Bacterial transcriptional regulator; Region: IclR; pfam01614 1310115004880 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1310115004881 putative active site [active] 1310115004882 homotetrameric interface [polypeptide binding]; other site 1310115004883 metal binding site [ion binding]; metal-binding site 1310115004884 biotin carboxylase-like protein; Validated; Region: PRK06524 1310115004885 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1310115004886 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1310115004887 Beta-lactamase; Region: Beta-lactamase; pfam00144 1310115004888 Predicted transcriptional regulators [Transcription]; Region: COG1733 1310115004889 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1310115004890 dimerization interface [polypeptide binding]; other site 1310115004891 putative DNA binding site [nucleotide binding]; other site 1310115004892 putative Zn2+ binding site [ion binding]; other site 1310115004893 Predicted transcriptional regulators [Transcription]; Region: COG1733 1310115004894 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1310115004895 FAD binding domain; Region: FAD_binding_4; pfam01565 1310115004896 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1310115004897 Berberine and berberine like; Region: BBE; pfam08031 1310115004898 TIGR03086 family protein; Region: TIGR03086 1310115004899 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1310115004900 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1310115004901 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1310115004902 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1310115004903 Beta-lactamase; Region: Beta-lactamase; pfam00144 1310115004904 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 1310115004905 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 1310115004906 NAD(P) binding site [chemical binding]; other site 1310115004907 catalytic residues [active] 1310115004908 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 1310115004909 putative catalytic residue [active] 1310115004910 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 1310115004911 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1310115004912 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 1310115004913 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 1310115004914 gating phenylalanine in ion channel; other site 1310115004915 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 1310115004916 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1310115004917 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1310115004918 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 1310115004919 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 1310115004920 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310115004921 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 1310115004922 putative substrate translocation pore; other site 1310115004923 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 1310115004924 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1310115004925 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1310115004926 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1310115004927 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1310115004928 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 1310115004929 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3742 1310115004930 putative active site [active] 1310115004931 Protein tyrosine kinase; Region: Pkinase_Tyr; pfam07714 1310115004932 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1310115004933 active site 1310115004934 ATP binding site [chemical binding]; other site 1310115004935 substrate binding site [chemical binding]; other site 1310115004936 activation loop (A-loop); other site 1310115004937 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1310115004938 Thioredoxin; Region: Thioredoxin_4; cl17273 1310115004939 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 1310115004940 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 1310115004941 active site 1310115004942 metal binding site [ion binding]; metal-binding site 1310115004943 nudix motif; other site 1310115004944 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1310115004945 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1310115004946 active site 1310115004947 ATP binding site [chemical binding]; other site 1310115004948 substrate binding site [chemical binding]; other site 1310115004949 activation loop (A-loop); other site 1310115004950 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1310115004951 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1310115004952 phosphopeptide binding site; other site 1310115004953 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1310115004954 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1310115004955 phosphopeptide binding site; other site 1310115004956 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 1310115004957 The Eye Pigment Precursor Transporter (EPP) Family protein; Region: 3a01204; TIGR00955 1310115004958 Walker A/P-loop; other site 1310115004959 ATP binding site [chemical binding]; other site 1310115004960 Q-loop/lid; other site 1310115004961 ABC transporter signature motif; other site 1310115004962 Walker B; other site 1310115004963 D-loop; other site 1310115004964 H-loop/switch region; other site 1310115004965 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1310115004966 acyl-CoA synthetase; Provisional; Region: PRK13388 1310115004967 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1310115004968 acyl-activating enzyme (AAE) consensus motif; other site 1310115004969 AMP binding site [chemical binding]; other site 1310115004970 active site 1310115004971 CoA binding site [chemical binding]; other site 1310115004972 hypothetical protein; Provisional; Region: PRK06185 1310115004973 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1310115004974 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1310115004975 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1310115004976 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115004977 PPE family; Region: PPE; pfam00823 1310115004978 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310115004979 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310115004980 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 1310115004981 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1310115004982 Cutinase; Region: Cutinase; pfam01083 1310115004983 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1310115004984 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1310115004985 Uncharacterized conserved protein [Function unknown]; Region: COG0393 1310115004986 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 1310115004987 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1310115004988 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1310115004989 active site 1310115004990 Integrase core domain; Region: rve; pfam00665 1310115004991 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1310115004992 putative homotetramer interface [polypeptide binding]; other site 1310115004993 putative homodimer interface [polypeptide binding]; other site 1310115004994 putative allosteric switch controlling residues; other site 1310115004995 putative metal binding site [ion binding]; other site 1310115004996 putative homodimer-homodimer interface [polypeptide binding]; other site 1310115004997 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1310115004998 PE family; Region: PE; pfam00934 1310115004999 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1310115005000 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1310115005001 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1310115005002 catalytic residue [active] 1310115005003 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1310115005004 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 1310115005005 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1310115005006 metal binding site [ion binding]; metal-binding site 1310115005007 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 1310115005008 FAD binding domain; Region: FAD_binding_4; pfam01565 1310115005009 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1310115005010 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1310115005011 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1310115005012 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1310115005013 Bacterial transcriptional regulator; Region: IclR; pfam01614 1310115005014 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1310115005015 FAD binding domain; Region: FAD_binding_4; pfam01565 1310115005016 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310115005017 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310115005018 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1310115005019 Cytochrome P450; Region: p450; cl12078 1310115005020 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 1310115005021 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1310115005022 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1310115005023 Protein of unknown function (DUF690); Region: DUF690; pfam05108 1310115005024 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1310115005025 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1310115005026 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1310115005027 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1310115005028 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1310115005029 Cytochrome P450; Region: p450; cl12078 1310115005030 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1310115005031 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115005032 PPE family; Region: PPE; pfam00823 1310115005033 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1310115005034 PE family; Region: PE; pfam00934 1310115005035 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115005036 PPE family; Region: PPE; pfam00823 1310115005037 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1310115005038 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115005039 PPE family; Region: PPE; pfam00823 1310115005040 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1310115005041 PE family; Region: PE; pfam00934 1310115005042 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1310115005043 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1310115005044 EspG family; Region: ESX-1_EspG; pfam14011 1310115005045 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1310115005046 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1310115005047 catalytic residues [active] 1310115005048 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1310115005049 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 1310115005050 active site 1310115005051 catalytic residues [active] 1310115005052 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1310115005053 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1310115005054 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1310115005055 Walker A motif; other site 1310115005056 ATP binding site [chemical binding]; other site 1310115005057 Walker B motif; other site 1310115005058 arginine finger; other site 1310115005059 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115005060 PPE family; Region: PPE; pfam00823 1310115005061 PE-PPE domain; Region: PE-PPE; pfam08237 1310115005062 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115005063 PPE family; Region: PPE; pfam00823 1310115005064 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115005065 PPE family; Region: PPE; pfam00823 1310115005066 PE family; Region: PE; pfam00934 1310115005067 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1310115005068 PE family; Region: PE; pfam00934 1310115005069 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115005070 PPE family; Region: PPE; pfam00823 1310115005071 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115005072 PPE family; Region: PPE; pfam00823 1310115005073 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115005074 PPE family; Region: PPE; pfam00823 1310115005075 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1310115005076 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1310115005077 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1310115005078 MgtC family; Region: MgtC; pfam02308 1310115005079 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1310115005080 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1310115005081 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 1310115005082 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1310115005083 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1310115005084 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310115005085 hypothetical protein; Validated; Region: PRK07121 1310115005086 PE family; Region: PE; pfam00934 1310115005087 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 1310115005088 ABC transporter transmembrane region 2; Region: ABC_membrane_2; pfam06472 1310115005089 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 1310115005090 hypothetical protein; Provisional; Region: PRK05858 1310115005091 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1310115005092 PYR/PP interface [polypeptide binding]; other site 1310115005093 dimer interface [polypeptide binding]; other site 1310115005094 TPP binding site [chemical binding]; other site 1310115005095 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1310115005096 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 1310115005097 TPP-binding site; other site 1310115005098 dimer interface [polypeptide binding]; other site 1310115005099 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 1310115005100 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 1310115005101 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1310115005102 nucleotide binding region [chemical binding]; other site 1310115005103 ATP-binding site [chemical binding]; other site 1310115005104 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1310115005105 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1310115005106 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1310115005107 Protein of unknown function (DUF1290); Region: DUF1290; cl01587 1310115005108 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1310115005109 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1310115005110 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1310115005111 lipoyl attachment site [posttranslational modification]; other site 1310115005112 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1310115005113 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1310115005114 phosphopeptide binding site; other site 1310115005115 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1310115005116 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1310115005117 DNA binding residues [nucleotide binding] 1310115005118 Bifunctional nuclease; Region: DNase-RNase; pfam02577 1310115005119 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1310115005120 DNA binding residues [nucleotide binding] 1310115005121 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1310115005122 putative dimer interface [polypeptide binding]; other site 1310115005123 glycine dehydrogenase; Provisional; Region: PRK05367 1310115005124 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1310115005125 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310115005126 tetramer interface [polypeptide binding]; other site 1310115005127 catalytic residue [active] 1310115005128 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1310115005129 tetramer interface [polypeptide binding]; other site 1310115005130 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310115005131 catalytic residue [active] 1310115005132 haloalkane dehalogenase; Provisional; Region: PRK03204 1310115005133 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1310115005134 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 1310115005135 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 1310115005136 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1310115005137 metal ion-dependent adhesion site (MIDAS); other site 1310115005138 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 1310115005139 active site 1310115005140 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1310115005141 putative active site [active] 1310115005142 Domain of unknown function DUF21; Region: DUF21; pfam01595 1310115005143 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1310115005144 FOG: CBS domain [General function prediction only]; Region: COG0517 1310115005145 Domain of unknown function DUF21; Region: DUF21; pfam01595 1310115005146 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1310115005147 Domain of unknown function DUF21; Region: DUF21; pfam01595 1310115005148 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1310115005149 Transporter associated domain; Region: CorC_HlyC; smart01091 1310115005150 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 1310115005151 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1310115005152 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1310115005153 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1310115005154 active site 1310115005155 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1310115005156 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1310115005157 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1310115005158 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1310115005159 Predicted transcriptional regulator [Transcription]; Region: COG3682 1310115005160 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1310115005161 CoenzymeA binding site [chemical binding]; other site 1310115005162 subunit interaction site [polypeptide binding]; other site 1310115005163 PHB binding site; other site 1310115005164 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1310115005165 alpha-gamma subunit interface [polypeptide binding]; other site 1310115005166 beta-gamma subunit interface [polypeptide binding]; other site 1310115005167 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1310115005168 gamma-beta subunit interface [polypeptide binding]; other site 1310115005169 alpha-beta subunit interface [polypeptide binding]; other site 1310115005170 urease subunit alpha; Reviewed; Region: ureC; PRK13206 1310115005171 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1310115005172 subunit interactions [polypeptide binding]; other site 1310115005173 active site 1310115005174 flap region; other site 1310115005175 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1310115005176 UreF; Region: UreF; pfam01730 1310115005177 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1310115005178 UreD urease accessory protein; Region: UreD; cl00530 1310115005179 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1310115005180 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1310115005181 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1310115005182 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1310115005183 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1310115005184 classical (c) SDRs; Region: SDR_c; cd05233 1310115005185 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 1310115005186 NAD(P) binding site [chemical binding]; other site 1310115005187 active site 1310115005188 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1310115005189 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1310115005190 sulfate transport protein; Provisional; Region: cysT; CHL00187 1310115005191 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1310115005192 dimer interface [polypeptide binding]; other site 1310115005193 conserved gate region; other site 1310115005194 putative PBP binding loops; other site 1310115005195 ABC-ATPase subunit interface; other site 1310115005196 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 1310115005197 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1310115005198 Walker A/P-loop; other site 1310115005199 ATP binding site [chemical binding]; other site 1310115005200 Q-loop/lid; other site 1310115005201 ABC transporter signature motif; other site 1310115005202 Walker B; other site 1310115005203 D-loop; other site 1310115005204 H-loop/switch region; other site 1310115005205 TOBE domain; Region: TOBE; pfam03459 1310115005206 Fibronectin-attachment protein (FAP); Region: FAP; pfam07174 1310115005207 Predicted membrane protein [Function unknown]; Region: COG2261 1310115005208 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 1310115005209 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 1310115005210 putative NAD(P) binding site [chemical binding]; other site 1310115005211 putative substrate binding site [chemical binding]; other site 1310115005212 catalytic Zn binding site [ion binding]; other site 1310115005213 structural Zn binding site [ion binding]; other site 1310115005214 CAAX protease self-immunity; Region: Abi; pfam02517 1310115005215 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1310115005216 MOSC domain; Region: MOSC; pfam03473 1310115005217 short chain dehydrogenase; Provisional; Region: PRK07825 1310115005218 classical (c) SDRs; Region: SDR_c; cd05233 1310115005219 NAD(P) binding site [chemical binding]; other site 1310115005220 active site 1310115005221 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1310115005222 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1310115005223 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1310115005224 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1310115005225 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 1310115005226 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1310115005227 active site 1310115005228 hypothetical protein; Provisional; Region: PRK12320 1310115005229 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310115005230 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1310115005231 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1310115005232 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1310115005233 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1310115005234 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 1310115005235 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 1310115005236 active site 1310115005237 substrate binding site [chemical binding]; other site 1310115005238 FMN binding site [chemical binding]; other site 1310115005239 putative catalytic residues [active] 1310115005240 Uncharacterized conserved protein [Function unknown]; Region: COG5579 1310115005241 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1310115005242 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 1310115005243 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1310115005244 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1310115005245 heme binding site [chemical binding]; other site 1310115005246 ferroxidase pore; other site 1310115005247 ferroxidase diiron center [ion binding]; other site 1310115005248 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310115005249 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1310115005250 putative substrate translocation pore; other site 1310115005251 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310115005252 putative substrate translocation pore; other site 1310115005253 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cl00333 1310115005254 23S rRNA interface [nucleotide binding]; other site 1310115005255 L3 interface [polypeptide binding]; other site 1310115005256 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1310115005257 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1310115005258 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1310115005259 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1310115005260 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1310115005261 Cytochrome P450; Region: p450; cl12078 1310115005262 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 1310115005263 short chain dehydrogenase; Provisional; Region: PRK08267 1310115005264 classical (c) SDR, subgroup 9; Region: SDR_c9; cd08931 1310115005265 putative NAD(P) binding site [chemical binding]; other site 1310115005266 active site 1310115005267 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1310115005268 hydrophobic ligand binding site; other site 1310115005269 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1310115005270 chorismate mutase; Provisional; Region: PRK09269 1310115005271 chorismate mutase, putative; Region: CM_mono2; TIGR01806 1310115005272 Putative esterase; Region: Esterase; pfam00756 1310115005273 potential frameshift: common BLAST hit: gi|433634937|ref|YP_007268564.1| Putative S-adenosyl-L-methionine-dependent methyltransferase 1310115005274 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1310115005275 Nitronate monooxygenase; Region: NMO; pfam03060 1310115005276 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1310115005277 FMN binding site [chemical binding]; other site 1310115005278 substrate binding site [chemical binding]; other site 1310115005279 putative catalytic residue [active] 1310115005280 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 2; Region: FDH_like_2; cd08284 1310115005281 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1310115005282 catalytic Zn binding site [ion binding]; other site 1310115005283 NAD(P) binding site [chemical binding]; other site 1310115005284 structural Zn binding site [ion binding]; other site 1310115005285 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1310115005286 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1310115005287 Leucine carboxyl methyltransferase; Region: LCM; cl01306 1310115005288 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1310115005289 putative active site [active] 1310115005290 dimerization interface [polypeptide binding]; other site 1310115005291 putative tRNAtyr binding site [nucleotide binding]; other site 1310115005292 Domain of unknown function DUF77; Region: DUF77; pfam01910 1310115005293 Macro domain, Unknown family 2. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_2; cd03330 1310115005294 putative ADP-ribose binding site [chemical binding]; other site 1310115005295 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1310115005296 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1310115005297 cyclase homology domain; Region: CHD; cd07302 1310115005298 nucleotidyl binding site; other site 1310115005299 metal binding site [ion binding]; metal-binding site 1310115005300 dimer interface [polypeptide binding]; other site 1310115005301 competence damage-inducible protein A; Provisional; Region: PRK00549 1310115005302 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1310115005303 putative MPT binding site; other site 1310115005304 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 1310115005305 putative sialic acid transporter; Region: 2A0112; TIGR00891 1310115005306 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310115005307 putative substrate translocation pore; other site 1310115005308 Predicted membrane protein [Function unknown]; Region: COG1950 1310115005309 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1310115005310 anti sigma factor interaction site; other site 1310115005311 regulatory phosphorylation site [posttranslational modification]; other site 1310115005312 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1310115005313 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 1310115005314 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1310115005315 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 1310115005316 dimer interface [polypeptide binding]; other site 1310115005317 active site 1310115005318 heme binding site [chemical binding]; other site 1310115005319 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1310115005320 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1310115005321 metal binding site 2 [ion binding]; metal-binding site 1310115005322 putative DNA binding helix; other site 1310115005323 metal binding site 1 [ion binding]; metal-binding site 1310115005324 dimer interface [polypeptide binding]; other site 1310115005325 structural Zn2+ binding site [ion binding]; other site 1310115005326 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1310115005327 substrate binding site [chemical binding]; other site 1310115005328 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1310115005329 substrate binding site [chemical binding]; other site 1310115005330 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1310115005331 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR3; cd08275 1310115005332 putative NAD(P) binding site [chemical binding]; other site 1310115005333 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1310115005334 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1310115005335 tetramer interface [polypeptide binding]; other site 1310115005336 active site 1310115005337 Mg2+/Mn2+ binding site [ion binding]; other site 1310115005338 Isocitrate lyase [Energy production and conversion]; Region: AceA; COG2224 1310115005339 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115005340 PPE family; Region: PPE; pfam00823 1310115005341 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115005342 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310115005343 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310115005344 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115005345 PPE family; Region: PPE; pfam00823 1310115005346 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310115005347 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310115005348 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1310115005349 putative hydrophobic ligand binding site [chemical binding]; other site 1310115005350 protein interface [polypeptide binding]; other site 1310115005351 gate; other site 1310115005352 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1310115005353 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1310115005354 putative acyl-acceptor binding pocket; other site 1310115005355 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1310115005356 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1310115005357 Beta-lactamase; Region: Beta-lactamase; pfam00144 1310115005358 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1310115005359 Beta-lactamase; Region: Beta-lactamase; pfam00144 1310115005360 putative fatty-acid--CoA ligase; Provisional; Region: PRK12476 1310115005361 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1310115005362 acyl-activating enzyme (AAE) consensus motif; other site 1310115005363 active site 1310115005364 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 1310115005365 Uncharacterized conserved protein [Function unknown]; Region: COG3361 1310115005366 short chain dehydrogenase; Provisional; Region: PRK05867 1310115005367 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310115005368 NAD(P) binding site [chemical binding]; other site 1310115005369 active site 1310115005370 TIGR03085 family protein; Region: TIGR03085 1310115005371 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1310115005372 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1310115005373 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1310115005374 Helix-turn-helix domain; Region: HTH_18; pfam12833 1310115005375 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1310115005376 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1310115005377 conserved cys residue [active] 1310115005378 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1310115005379 dimer interface [polypeptide binding]; other site 1310115005380 catalytic triad [active] 1310115005381 peroxidatic and resolving cysteines [active] 1310115005382 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1310115005383 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1310115005384 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1310115005385 active site 1310115005386 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1310115005387 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 1310115005388 FAD binding site [chemical binding]; other site 1310115005389 substrate binding site [chemical binding]; other site 1310115005390 catalytic base [active] 1310115005391 enoyl-CoA hydratase; Provisional; Region: PRK08290 1310115005392 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1310115005393 substrate binding site [chemical binding]; other site 1310115005394 oxyanion hole (OAH) forming residues; other site 1310115005395 trimer interface [polypeptide binding]; other site 1310115005396 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1310115005397 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1310115005398 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 1310115005399 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1310115005400 catalytic loop [active] 1310115005401 iron binding site [ion binding]; other site 1310115005402 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 1310115005403 FAD binding pocket [chemical binding]; other site 1310115005404 FAD binding motif [chemical binding]; other site 1310115005405 phosphate binding motif [ion binding]; other site 1310115005406 beta-alpha-beta structure motif; other site 1310115005407 NAD binding pocket [chemical binding]; other site 1310115005408 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1310115005409 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1310115005410 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1310115005411 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 1310115005412 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1310115005413 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 1310115005414 dimerization interface [polypeptide binding]; other site 1310115005415 active site 1310115005416 classical (c) SDR, subgroup 12; Region: SDR_c12; cd08944 1310115005417 putative NAD(P) binding site [chemical binding]; other site 1310115005418 active site 1310115005419 homodimer interface [polypeptide binding]; other site 1310115005420 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1310115005421 SEC-C motif; Region: SEC-C; pfam02810 1310115005422 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1310115005423 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1310115005424 active site 1310115005425 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 1310115005426 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487 1310115005427 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 1310115005428 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1310115005429 non-specific DNA binding site [nucleotide binding]; other site 1310115005430 salt bridge; other site 1310115005431 sequence-specific DNA binding site [nucleotide binding]; other site 1310115005432 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 1310115005433 Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693 1310115005434 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 1310115005435 putative active site [active] 1310115005436 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1310115005437 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310115005438 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310115005439 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310115005440 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310115005441 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1310115005442 Permease; Region: Permease; pfam02405 1310115005443 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1310115005444 Permease; Region: Permease; pfam02405 1310115005445 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1310115005446 mce related protein; Region: MCE; pfam02470 1310115005447 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1310115005448 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1310115005449 mce related protein; Region: MCE; pfam02470 1310115005450 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1310115005451 mce related protein; Region: MCE; pfam02470 1310115005452 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1310115005453 mce related protein; Region: MCE; pfam02470 1310115005454 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1310115005455 mce related protein; Region: MCE; pfam02470 1310115005456 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1310115005457 mce related protein; Region: MCE; pfam02470 1310115005458 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1310115005459 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1310115005460 YacP-like NYN domain; Region: NYN_YacP; cl01491 1310115005461 Peptidase family M48; Region: Peptidase_M48; pfam01435 1310115005462 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310115005463 S-adenosylmethionine binding site [chemical binding]; other site 1310115005464 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1310115005465 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1310115005466 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1310115005467 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1310115005468 dimer interface [polypeptide binding]; other site 1310115005469 putative radical transfer pathway; other site 1310115005470 diiron center [ion binding]; other site 1310115005471 tyrosyl radical; other site 1310115005472 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 1310115005473 putative active site [active] 1310115005474 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 1310115005475 potential frameshift: common BLAST hit: gi|471337940|ref|YP_007610653.1| PE-PGRS family protein 1310115005476 Cutinase; Region: Cutinase; pfam01083 1310115005477 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 1310115005478 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 1310115005479 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1310115005480 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1310115005481 dimerization interface [polypeptide binding]; other site 1310115005482 Lysine efflux permease [General function prediction only]; Region: COG1279 1310115005483 Cellulose binding domain; Region: CBM_2; pfam00553 1310115005484 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310115005485 S-adenosylmethionine binding site [chemical binding]; other site 1310115005486 Uncharacterized conserved protein [Function unknown]; Region: COG5654 1310115005487 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 1310115005488 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 1310115005489 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310115005490 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1310115005491 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1310115005492 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1310115005493 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1310115005494 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 1310115005495 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1310115005496 dimerization interface [polypeptide binding]; other site 1310115005497 putative DNA binding site [nucleotide binding]; other site 1310115005498 putative Zn2+ binding site [ion binding]; other site 1310115005499 Hemerythrin-like domain; Region: Hr-like; cd12108 1310115005500 Fe binding site [ion binding]; other site 1310115005501 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1310115005502 Ligand Binding Site [chemical binding]; other site 1310115005503 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1310115005504 Ligand Binding Site [chemical binding]; other site 1310115005505 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1310115005506 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1310115005507 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1310115005508 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1310115005509 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1310115005510 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1310115005511 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1310115005512 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1310115005513 tetramer interface [polypeptide binding]; other site 1310115005514 active site 1310115005515 Mg2+/Mn2+ binding site [ion binding]; other site 1310115005516 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1310115005517 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1310115005518 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 1310115005519 3beta17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 3beta-17beta-HSD_like_SDR_c; cd05341 1310115005520 homotetramer interface [polypeptide binding]; other site 1310115005521 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1310115005522 NAD binding site [chemical binding]; other site 1310115005523 homodimer interface [polypeptide binding]; other site 1310115005524 active site 1310115005525 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1310115005526 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310115005527 S-adenosylmethionine binding site [chemical binding]; other site 1310115005528 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1310115005529 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 1310115005530 Predicted kinase [General function prediction only]; Region: COG0645 1310115005531 AAA domain; Region: AAA_17; pfam13207 1310115005532 Universal stress protein family; Region: Usp; pfam00582 1310115005533 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1310115005534 Ligand Binding Site [chemical binding]; other site 1310115005535 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1310115005536 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 1310115005537 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 1310115005538 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1310115005539 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1310115005540 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1310115005541 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1310115005542 Ferredoxin [Energy production and conversion]; Region: COG1146 1310115005543 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1310115005544 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 1310115005545 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1310115005546 Walker A motif; other site 1310115005547 ATP binding site [chemical binding]; other site 1310115005548 Walker B motif; other site 1310115005549 arginine finger; other site 1310115005550 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1310115005551 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1310115005552 putative active site [active] 1310115005553 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1310115005554 MarR family; Region: MarR_2; pfam12802 1310115005555 Phage envelope protein [General function prediction only]; Region: COG5562 1310115005556 Predicted helicase [General function prediction only]; Region: COG4889 1310115005557 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1310115005558 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1310115005559 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1310115005560 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1310115005561 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1310115005562 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1310115005563 active site 1310115005564 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1310115005565 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1310115005566 non-specific DNA binding site [nucleotide binding]; other site 1310115005567 salt bridge; other site 1310115005568 sequence-specific DNA binding site [nucleotide binding]; other site 1310115005569 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 1310115005570 Uncharacterized conserved protein [Function unknown]; Region: COG2442 1310115005571 Predicted helicase [General function prediction only]; Region: COG4889 1310115005572 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1310115005573 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1310115005574 non-specific DNA binding site [nucleotide binding]; other site 1310115005575 salt bridge; other site 1310115005576 sequence-specific DNA binding site [nucleotide binding]; other site 1310115005577 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4683 1310115005578 Restriction endonuclease; Region: Mrr_cat_2; pfam13156 1310115005579 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1310115005580 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 1310115005581 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1310115005582 ATP binding site [chemical binding]; other site 1310115005583 putative Mg++ binding site [ion binding]; other site 1310115005584 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1310115005585 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1310115005586 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1310115005587 Ligand Binding Site [chemical binding]; other site 1310115005588 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1310115005589 Ligand Binding Site [chemical binding]; other site 1310115005590 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1310115005591 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1310115005592 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1310115005593 Histidine kinase; Region: HisKA_3; pfam07730 1310115005594 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1310115005595 Ligand Binding Site [chemical binding]; other site 1310115005596 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1310115005597 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1310115005598 putative substrate binding site [chemical binding]; other site 1310115005599 putative ATP binding site [chemical binding]; other site 1310115005600 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1310115005601 active site 1310115005602 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 1310115005603 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1310115005604 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1310115005605 putative dimer interface [polypeptide binding]; other site 1310115005606 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1310115005607 dimer interface [polypeptide binding]; other site 1310115005608 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 1310115005609 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1310115005610 putative DNA binding site [nucleotide binding]; other site 1310115005611 dimerization interface [polypeptide binding]; other site 1310115005612 putative Zn2+ binding site [ion binding]; other site 1310115005613 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 1310115005614 putative hydrophobic ligand binding site [chemical binding]; other site 1310115005615 CLM binding site; other site 1310115005616 L1 loop; other site 1310115005617 DNA binding site [nucleotide binding] 1310115005618 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1310115005619 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1310115005620 MDMPI C-terminal domain; Region: MDMPI_C; pfam07398 1310115005621 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1310115005622 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 1310115005623 nucleophile elbow; other site 1310115005624 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1310115005625 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1310115005626 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1310115005627 Walker A/P-loop; other site 1310115005628 ATP binding site [chemical binding]; other site 1310115005629 Q-loop/lid; other site 1310115005630 ABC transporter signature motif; other site 1310115005631 Walker B; other site 1310115005632 D-loop; other site 1310115005633 H-loop/switch region; other site 1310115005634 TOBE domain; Region: TOBE_2; pfam08402 1310115005635 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1310115005636 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1310115005637 dimer interface [polypeptide binding]; other site 1310115005638 conserved gate region; other site 1310115005639 putative PBP binding loops; other site 1310115005640 ABC-ATPase subunit interface; other site 1310115005641 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1310115005642 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1310115005643 dimer interface [polypeptide binding]; other site 1310115005644 conserved gate region; other site 1310115005645 putative PBP binding loops; other site 1310115005646 ABC-ATPase subunit interface; other site 1310115005647 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1310115005648 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1310115005649 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 1310115005650 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1310115005651 Isochorismatase family; Region: Isochorismatase; pfam00857 1310115005652 catalytic triad [active] 1310115005653 metal binding site [ion binding]; metal-binding site 1310115005654 conserved cis-peptide bond; other site 1310115005655 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 1310115005656 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1310115005657 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1310115005658 substrate binding pocket [chemical binding]; other site 1310115005659 catalytic triad [active] 1310115005660 hypothetical protein; Provisional; Region: PRK05865 1310115005661 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310115005662 NAD(P) binding site [chemical binding]; other site 1310115005663 active site 1310115005664 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1310115005665 potential frameshift: common BLAST hit: gi|339632088|ref|YP_004723730.1| polyketide synthase 1310115005666 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1310115005667 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1310115005668 active site 1310115005669 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1310115005670 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1310115005671 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310115005672 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1310115005673 Enoylreductase; Region: PKS_ER; smart00829 1310115005674 NAD(P) binding site [chemical binding]; other site 1310115005675 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1310115005676 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1310115005677 putative NADP binding site [chemical binding]; other site 1310115005678 active site 1310115005679 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1310115005680 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 1310115005681 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1310115005682 putative active site [active] 1310115005683 catalytic triad [active] 1310115005684 putative dimer interface [polypeptide binding]; other site 1310115005685 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 1310115005686 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 1310115005687 Ligand binding site; other site 1310115005688 Putative Catalytic site; other site 1310115005689 DXD motif; other site 1310115005690 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1310115005691 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1310115005692 active site 1310115005693 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 1310115005694 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1310115005695 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1310115005696 30S ribosomal protein S18; Provisional; Region: PRK13401 1310115005697 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1310115005698 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1310115005699 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1310115005700 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1310115005701 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1310115005702 intersubunit interface [polypeptide binding]; other site 1310115005703 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1310115005704 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1310115005705 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 1310115005706 potential frameshift: common BLAST hit: gi|15841550|ref|NP_336587.1| cobaltochelatase subunit CobN 1310115005707 PemK-like protein; Region: PemK; pfam02452 1310115005708 precorrin-3B synthase; Region: CobG; TIGR02435 1310115005709 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1310115005710 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 1310115005711 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1310115005712 active site 1310115005713 SAM binding site [chemical binding]; other site 1310115005714 homodimer interface [polypeptide binding]; other site 1310115005715 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1310115005716 active site 1310115005717 SAM binding site [chemical binding]; other site 1310115005718 homodimer interface [polypeptide binding]; other site 1310115005719 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1310115005720 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310115005721 S-adenosylmethionine binding site [chemical binding]; other site 1310115005722 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 1310115005723 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1310115005724 RNA polymerase sigma factor SigC; Reviewed; Region: PRK09649 1310115005725 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1310115005726 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1310115005727 DNA binding residues [nucleotide binding] 1310115005728 potential frameshift: common BLAST hit: gi|471338042|ref|YP_007610755.1| cobalt-precorrin-6x reductase 1310115005729 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1310115005730 active site 1310115005731 SAM binding site [chemical binding]; other site 1310115005732 homodimer interface [polypeptide binding]; other site 1310115005733 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1310115005734 active site 1310115005735 putative homodimer interface [polypeptide binding]; other site 1310115005736 SAM binding site [chemical binding]; other site 1310115005737 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1310115005738 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1310115005739 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310115005740 NAD(P) binding site [chemical binding]; other site 1310115005741 active site 1310115005742 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1310115005743 Catalytic domain of uncharacterized Mycobacterium tuberculosis Rv2075c-like proteins; Region: PI-PLCc_Rv2075c_like; cd08590 1310115005744 putative active site [active] 1310115005745 catalytic site [active] 1310115005746 putative metal binding site [ion binding]; other site 1310115005747 C-type lectin (CTL)/C-type lectin-like (CTLD) domain; Region: CLECT; cl02432 1310115005748 Protein of unknown function (DUF2563); Region: DUF2563; pfam10817 1310115005749 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1310115005750 putative transposase OrfB; Reviewed; Region: PHA02517 1310115005751 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1310115005752 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1310115005753 active site 1310115005754 ATP binding site [chemical binding]; other site 1310115005755 substrate binding site [chemical binding]; other site 1310115005756 activation loop (A-loop); other site 1310115005757 PknH-like extracellular domain; Region: PknH_C; pfam14032 1310115005758 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1310115005759 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1310115005760 active site 1310115005761 5'-3' exonuclease, N-terminal resolvase-like domain; Region: 5_3_exonuc_N; pfam02739 1310115005762 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1310115005763 active site 1310115005764 metal binding site 1 [ion binding]; metal-binding site 1310115005765 putative 5' ssDNA interaction site; other site 1310115005766 metal binding site 3; metal-binding site 1310115005767 metal binding site 2 [ion binding]; metal-binding site 1310115005768 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1310115005769 putative DNA binding site [nucleotide binding]; other site 1310115005770 putative metal binding site [ion binding]; other site 1310115005771 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 1310115005772 potential frameshift: common BLAST hit: gi|471338067|ref|YP_007610780.1| ATP-dependent DNA helicase 1310115005773 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1310115005774 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 1310115005775 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 1310115005776 Predicted transcriptional regulator [Transcription]; Region: COG2378 1310115005777 WYL domain; Region: WYL; pfam13280 1310115005778 Predicted transcriptional regulator [Transcription]; Region: COG2378 1310115005779 WYL domain; Region: WYL; pfam13280 1310115005780 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 1310115005781 PE family; Region: PE; pfam00934 1310115005782 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1310115005783 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1310115005784 active site 1310115005785 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1310115005786 SNF2 Helicase protein; Region: DUF3670; pfam12419 1310115005787 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1310115005788 ATP binding site [chemical binding]; other site 1310115005789 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1310115005790 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1310115005791 ATP-binding site [chemical binding]; other site 1310115005792 Uncharacterized conserved protein [Function unknown]; Region: COG4279 1310115005793 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1310115005794 putative active site [active] 1310115005795 PE family; Region: PE; pfam00934 1310115005796 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115005797 PPE family; Region: PPE; pfam00823 1310115005798 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 1310115005799 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 1310115005800 active site 1310115005801 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 1310115005802 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 1310115005803 active site 1310115005804 Pup-like protein; Region: Pup; pfam05639 1310115005805 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 1310115005806 proteasome ATPase; Region: pup_AAA; TIGR03689 1310115005807 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1310115005808 Walker A motif; other site 1310115005809 ATP binding site [chemical binding]; other site 1310115005810 Walker B motif; other site 1310115005811 arginine finger; other site 1310115005812 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1310115005813 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550 1310115005814 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 1310115005815 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310115005816 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 1310115005817 Predicted membrane protein [Function unknown]; Region: COG3918 1310115005818 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1310115005819 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1310115005820 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1310115005821 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 1310115005822 homodimer interface [polypeptide binding]; other site 1310115005823 putative metal binding site [ion binding]; other site 1310115005824 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115005825 PPE family; Region: PPE; pfam00823 1310115005826 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1310115005827 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 1310115005828 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1310115005829 substrate binding pocket [chemical binding]; other site 1310115005830 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1310115005831 B12 binding site [chemical binding]; other site 1310115005832 cobalt ligand [ion binding]; other site 1310115005833 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1310115005834 PAC2 family; Region: PAC2; pfam09754 1310115005835 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1310115005836 short chain dehydrogenase; Provisional; Region: PRK05872 1310115005837 classical (c) SDRs; Region: SDR_c; cd05233 1310115005838 NAD(P) binding site [chemical binding]; other site 1310115005839 active site 1310115005840 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1310115005841 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 1310115005842 active site 1310115005843 HIGH motif; other site 1310115005844 nucleotide binding site [chemical binding]; other site 1310115005845 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1310115005846 active site 1310115005847 KMSKS motif; other site 1310115005848 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 1310115005849 putative tRNA binding surface [nucleotide binding]; other site 1310115005850 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1310115005851 active site 1310115005852 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1310115005853 conserved hypothetical protein; Region: TIGR03843 1310115005854 conserved hypothetical protein; Region: TIGR03847 1310115005855 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1310115005856 catalytic core [active] 1310115005857 undecaprenyl-diphosphatase UppP; Region: undec_PP_bacA; TIGR00753 1310115005858 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1310115005859 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1310115005860 quinone interaction residues [chemical binding]; other site 1310115005861 active site 1310115005862 catalytic residues [active] 1310115005863 FMN binding site [chemical binding]; other site 1310115005864 substrate binding site [chemical binding]; other site 1310115005865 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1310115005866 substrate binding site [chemical binding]; other site 1310115005867 hypothetical protein; Provisional; Region: PRK07906 1310115005868 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 1310115005869 putative metal binding site [ion binding]; other site 1310115005870 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 1310115005871 putative addiction module component, TIGR02574 family; Region: stabl_TIGR02574 1310115005872 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1310115005873 active site 1310115005874 DivIVA domain; Region: DivI1A_domain; TIGR03544 1310115005875 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1310115005876 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1310115005877 Predicted integral membrane protein [Function unknown]; Region: COG0762 1310115005878 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 1310115005879 Predicted enzyme with a TIM-barrel fold [General function prediction only]; Region: COG0325 1310115005880 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1310115005881 catalytic residue [active] 1310115005882 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1310115005883 uncharacterized protein, YfiH family; Region: TIGR00726 1310115005884 cell division protein FtsZ; Validated; Region: PRK09330 1310115005885 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1310115005886 nucleotide binding site [chemical binding]; other site 1310115005887 SulA interaction site; other site 1310115005888 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1310115005889 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1310115005890 Cell division protein FtsQ; Region: FtsQ; pfam03799 1310115005891 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1310115005892 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1310115005893 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1310115005894 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1310115005895 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1310115005896 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 1310115005897 active site 1310115005898 homodimer interface [polypeptide binding]; other site 1310115005899 cell division protein FtsW; Region: ftsW; TIGR02614 1310115005900 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369 1310115005901 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1310115005902 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1310115005903 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1310115005904 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1310115005905 Mg++ binding site [ion binding]; other site 1310115005906 putative catalytic motif [active] 1310115005907 putative substrate binding site [chemical binding]; other site 1310115005908 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 1310115005909 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1310115005910 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1310115005911 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1310115005912 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1310115005913 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1310115005914 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1310115005915 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310115005916 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310115005917 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1310115005918 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1310115005919 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1310115005920 PE family; Region: PE; pfam00934 1310115005921 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1310115005922 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1310115005923 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1310115005924 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 1310115005925 MraW methylase family; Region: Methyltransf_5; pfam01795 1310115005926 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 1310115005927 MraZ protein; Region: MraZ; pfam02381 1310115005928 MraZ protein; Region: MraZ; pfam02381 1310115005929 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 1310115005930 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 1310115005931 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1310115005932 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1310115005933 substrate binding pocket [chemical binding]; other site 1310115005934 chain length determination region; other site 1310115005935 substrate-Mg2+ binding site; other site 1310115005936 catalytic residues [active] 1310115005937 aspartate-rich region 1; other site 1310115005938 active site lid residues [active] 1310115005939 aspartate-rich region 2; other site 1310115005940 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1310115005941 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1310115005942 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1310115005943 active site 1310115005944 ATP binding site [chemical binding]; other site 1310115005945 substrate binding site [chemical binding]; other site 1310115005946 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1310115005947 substrate binding site [chemical binding]; other site 1310115005948 activation loop (A-loop); other site 1310115005949 activation loop (A-loop); other site 1310115005950 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1310115005951 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1310115005952 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG3200 1310115005953 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 1310115005954 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1310115005955 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1310115005956 putative acyl-acceptor binding pocket; other site 1310115005957 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1310115005958 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1310115005959 DTAP/Switch II; other site 1310115005960 Switch I; other site 1310115005961 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1310115005962 putative hydrophobic ligand binding site [chemical binding]; other site 1310115005963 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1310115005964 acyl-activating enzyme (AAE) consensus motif; other site 1310115005965 CoA binding site [chemical binding]; other site 1310115005966 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1310115005967 CoA binding site [chemical binding]; other site 1310115005968 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1310115005969 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1310115005970 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 1310115005971 hypothetical protein; Validated; Region: PRK07883 1310115005972 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1310115005973 active site 1310115005974 catalytic site [active] 1310115005975 substrate binding site [chemical binding]; other site 1310115005976 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1310115005977 GIY-YIG motif/motif A; other site 1310115005978 active site 1310115005979 catalytic site [active] 1310115005980 putative DNA binding site [nucleotide binding]; other site 1310115005981 metal binding site [ion binding]; metal-binding site 1310115005982 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1310115005983 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1310115005984 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1310115005985 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 1310115005986 Subunit I/III interface [polypeptide binding]; other site 1310115005987 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1310115005988 Cytochrome c; Region: Cytochrom_C; pfam00034 1310115005989 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1310115005990 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1310115005991 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1310115005992 iron-sulfur cluster [ion binding]; other site 1310115005993 [2Fe-2S] cluster binding site [ion binding]; other site 1310115005994 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1310115005995 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1310115005996 heme bH binding site [chemical binding]; other site 1310115005997 intrachain domain interface; other site 1310115005998 heme bL binding site [chemical binding]; other site 1310115005999 interchain domain interface [polypeptide binding]; other site 1310115006000 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 1310115006001 Qo binding site; other site 1310115006002 Protein of unknown function (DUF2561); Region: DUF2561; pfam10812 1310115006003 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1310115006004 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 1310115006005 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1310115006006 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1310115006007 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1310115006008 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1310115006009 dimer interface [polypeptide binding]; other site 1310115006010 active site 1310115006011 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1310115006012 Ligand Binding Site [chemical binding]; other site 1310115006013 Molecular Tunnel; other site 1310115006014 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 1310115006015 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1310115006016 substrate binding site [chemical binding]; other site 1310115006017 ATP binding site [chemical binding]; other site 1310115006018 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1310115006019 Glycerate kinase family; Region: Gly_kinase; pfam02595 1310115006020 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 1310115006021 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1310115006022 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1310115006023 putative dimer interface [polypeptide binding]; other site 1310115006024 active site pocket [active] 1310115006025 putative cataytic base [active] 1310115006026 Cobalamin-5-phosphate synthase; Region: CobS; pfam02654 1310115006027 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1310115006028 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1310115006029 homodimer interface [polypeptide binding]; other site 1310115006030 substrate-cofactor binding pocket; other site 1310115006031 catalytic residue [active] 1310115006032 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1310115006033 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1310115006034 cyclase homology domain; Region: CHD; cd07302 1310115006035 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1310115006036 nucleotidyl binding site; other site 1310115006037 metal binding site [ion binding]; metal-binding site 1310115006038 dimer interface [polypeptide binding]; other site 1310115006039 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1310115006040 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1310115006041 interface (dimer of trimers) [polypeptide binding]; other site 1310115006042 Substrate-binding/catalytic site; other site 1310115006043 Zn-binding sites [ion binding]; other site 1310115006044 short chain dehydrogenase; Validated; Region: PRK05855 1310115006045 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1310115006046 classical (c) SDRs; Region: SDR_c; cd05233 1310115006047 NAD(P) binding site [chemical binding]; other site 1310115006048 active site 1310115006049 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 1310115006050 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1310115006051 E3 interaction surface; other site 1310115006052 lipoyl attachment site [posttranslational modification]; other site 1310115006053 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1310115006054 E3 interaction surface; other site 1310115006055 lipoyl attachment site [posttranslational modification]; other site 1310115006056 e3 binding domain; Region: E3_binding; pfam02817 1310115006057 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1310115006058 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1310115006059 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1310115006060 putative NAD(P) binding site [chemical binding]; other site 1310115006061 putative active site [active] 1310115006062 lipoate-protein ligase B; Provisional; Region: PRK14345 1310115006063 lipoyl synthase; Provisional; Region: PRK05481 1310115006064 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1310115006065 FeS/SAM binding site; other site 1310115006066 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 1310115006067 RDD family; Region: RDD; pfam06271 1310115006068 glutamine synthetase, type I; Region: GlnA; TIGR00653 1310115006069 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1310115006070 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1310115006071 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 1310115006072 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1310115006073 metal binding triad; other site 1310115006074 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1310115006075 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1310115006076 metal binding triad; other site 1310115006077 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1310115006078 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1310115006079 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1310115006080 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1310115006081 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1310115006082 TAP-like protein; Region: Abhydrolase_4; pfam08386 1310115006083 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1310115006084 TAP-like protein; Region: Abhydrolase_4; pfam08386 1310115006085 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1310115006086 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1310115006087 oligomerization interface [polypeptide binding]; other site 1310115006088 active site 1310115006089 metal binding site [ion binding]; metal-binding site 1310115006090 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 1310115006091 putative active site; other site 1310115006092 putative metal binding residues [ion binding]; other site 1310115006093 signature motif; other site 1310115006094 putative triphosphate binding site [ion binding]; other site 1310115006095 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 1310115006096 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3826 1310115006097 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 1310115006098 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1310115006099 RNA/DNA hybrid binding site [nucleotide binding]; other site 1310115006100 active site 1310115006101 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1310115006102 catalytic core [active] 1310115006103 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 1310115006104 Putative zinc ribbon domain; Region: DUF164; pfam02591 1310115006105 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 1310115006106 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1310115006107 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1310115006108 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1310115006109 hypothetical protein; Provisional; Region: PRK07908 1310115006110 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1310115006111 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310115006112 homodimer interface [polypeptide binding]; other site 1310115006113 catalytic residue [active] 1310115006114 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1310115006115 PIN domain nuclease, a component of toxin-antitoxin system (PIN domain) [Signal transduction mechanisms]; Region: COG3744 1310115006116 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1310115006117 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1310115006118 active site 1310115006119 motif I; other site 1310115006120 motif II; other site 1310115006121 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1310115006122 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1310115006123 active site 1310115006124 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1310115006125 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 1310115006126 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 1310115006127 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1310115006128 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 1310115006129 dimer interface [polypeptide binding]; other site 1310115006130 catalytic triad [active] 1310115006131 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 1310115006132 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1310115006133 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1310115006134 dimer interface [polypeptide binding]; other site 1310115006135 TPP-binding site [chemical binding]; other site 1310115006136 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1310115006137 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1310115006138 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1310115006139 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1310115006140 acyl carrier protein; Provisional; Region: acpP; PRK00982 1310115006141 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 1310115006142 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1310115006143 dimer interface [polypeptide binding]; other site 1310115006144 active site 1310115006145 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 1310115006146 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1310115006147 dimer interface [polypeptide binding]; other site 1310115006148 active site 1310115006149 potential frameshift: common BLAST hit: gi|471338227|ref|YP_007610940.1| acetyl/propionyl-CoA carboxylase beta subunit 1310115006150 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1310115006151 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1310115006152 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310115006153 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310115006154 potential frameshift: common BLAST hit: gi|471338231|ref|YP_007610944.1| alkyldihydroxyacetonephosphate synthase 1310115006155 diacylglycerol kinase; Reviewed; Region: PRK11914 1310115006156 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1310115006157 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 1310115006158 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1310115006159 Beta-lactamase; Region: Beta-lactamase; pfam00144 1310115006160 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1310115006161 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310115006162 S-adenosylmethionine binding site [chemical binding]; other site 1310115006163 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 1310115006164 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1310115006165 NAD binding site [chemical binding]; other site 1310115006166 catalytic Zn binding site [ion binding]; other site 1310115006167 substrate binding site [chemical binding]; other site 1310115006168 structural Zn binding site [ion binding]; other site 1310115006169 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1310115006170 potential frameshift: common BLAST hit: gi|253798671|ref|YP_003031672.1| apolipoprotein N-acyltransferase 1310115006171 short chain dehydrogenase; Provisional; Region: PRK05854 1310115006172 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1310115006173 putative NAD(P) binding site [chemical binding]; other site 1310115006174 active site 1310115006175 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 1310115006176 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1310115006177 nucleotide binding site [chemical binding]; other site 1310115006178 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1310115006179 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1310115006180 Cytochrome P450; Region: p450; cl12078 1310115006181 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1310115006182 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1310115006183 Cytochrome P450; Region: p450; cl12078 1310115006184 Septum formation; Region: Septum_form; pfam13845 1310115006185 Protein of unknown function (DUF2695); Region: DUF2695; pfam10905 1310115006186 Predicted membrane protein [Function unknown]; Region: COG2149 1310115006187 Domain of unknown function (DUF202); Region: DUF202; pfam02656 1310115006188 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1310115006189 Cytochrome P450; Region: p450; cl12078 1310115006190 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial protein Rv2277c and similar proteins; Region: GDPD_Rv2277c_like; cd08580 1310115006191 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1310115006192 putative active site [active] 1310115006193 catalytic site [active] 1310115006194 putative metal binding site [ion binding]; other site 1310115006195 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1310115006196 FAD binding domain; Region: FAD_binding_4; pfam01565 1310115006197 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1310115006198 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1310115006199 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1310115006200 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1310115006201 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1310115006202 dimerization interface [polypeptide binding]; other site 1310115006203 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1310115006204 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1310115006205 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1310115006206 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1310115006207 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1310115006208 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1310115006209 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1310115006210 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1310115006211 CDP-diacylglycerol pyrophosphatase [Lipid metabolism]; Region: Cdh; COG2134 1310115006212 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1310115006213 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1310115006214 active site residue [active] 1310115006215 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1310115006216 active site residue [active] 1310115006217 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1310115006218 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1310115006219 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1310115006220 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310115006221 homodimer interface [polypeptide binding]; other site 1310115006222 catalytic residue [active] 1310115006223 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3196 1310115006224 haloalkane dehalogenase; Provisional; Region: PRK00870 1310115006225 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1310115006226 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1310115006227 active site 1310115006228 catalytic tetrad [active] 1310115006229 heat shock protein 90; Provisional; Region: PRK05218 1310115006230 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1310115006231 ATP binding site [chemical binding]; other site 1310115006232 Mg2+ binding site [ion binding]; other site 1310115006233 G-X-G motif; other site 1310115006234 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1310115006235 Cutinase; Region: Cutinase; pfam01083 1310115006236 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 1310115006237 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1310115006238 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 1310115006239 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1310115006240 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1310115006241 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1310115006242 Uncharacterized conserved protein [Function unknown]; Region: COG2442 1310115006243 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1310115006244 DNA binding site [nucleotide binding] 1310115006245 active site 1310115006246 Int/Topo IB signature motif; other site 1310115006247 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1310115006248 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1310115006249 DNA binding residues [nucleotide binding] 1310115006250 Family description; Region: UvrD_C_2; pfam13538 1310115006251 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1310115006252 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1310115006253 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1310115006254 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1310115006255 putative PBP binding loops; other site 1310115006256 ABC-ATPase subunit interface; other site 1310115006257 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1310115006258 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1310115006259 dimer interface [polypeptide binding]; other site 1310115006260 conserved gate region; other site 1310115006261 putative PBP binding loops; other site 1310115006262 ABC-ATPase subunit interface; other site 1310115006263 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1310115006264 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1310115006265 potential frameshift: common BLAST hit: gi|449064386|ref|YP_007431469.1| cationic amino acid transport integral membrane protein RocE 1310115006266 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 1310115006267 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1310115006268 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1310115006269 catalytic residue [active] 1310115006270 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1310115006271 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1310115006272 Amidinotransferase; Region: Amidinotransf; pfam02274 1310115006273 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1310115006274 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1310115006275 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1310115006276 putative DNA binding site [nucleotide binding]; other site 1310115006277 putative Zn2+ binding site [ion binding]; other site 1310115006278 AsnC family; Region: AsnC_trans_reg; pfam01037 1310115006279 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1310115006280 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1310115006281 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1310115006282 Walker A/P-loop; other site 1310115006283 ATP binding site [chemical binding]; other site 1310115006284 Q-loop/lid; other site 1310115006285 ABC transporter signature motif; other site 1310115006286 Walker B; other site 1310115006287 D-loop; other site 1310115006288 H-loop/switch region; other site 1310115006289 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1310115006290 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1310115006291 Walker A/P-loop; other site 1310115006292 ATP binding site [chemical binding]; other site 1310115006293 Q-loop/lid; other site 1310115006294 ABC transporter signature motif; other site 1310115006295 Walker B; other site 1310115006296 D-loop; other site 1310115006297 H-loop/switch region; other site 1310115006298 MarR family; Region: MarR; pfam01047 1310115006299 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1310115006300 PE family; Region: PE; pfam00934 1310115006301 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1310115006302 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310115006303 putative substrate translocation pore; other site 1310115006304 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 1310115006305 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1310115006306 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1310115006307 malate dehydrogenase; Provisional; Region: PRK13529 1310115006308 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1310115006309 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1310115006310 NAD(P) binding site [chemical binding]; other site 1310115006311 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310115006312 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1310115006313 putative substrate translocation pore; other site 1310115006314 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310115006315 putative substrate translocation pore; other site 1310115006316 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1310115006317 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1310115006318 dimer interface [polypeptide binding]; other site 1310115006319 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310115006320 catalytic residue [active] 1310115006321 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 1310115006322 serine O-acetyltransferase; Region: cysE; TIGR01172 1310115006323 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1310115006324 trimer interface [polypeptide binding]; other site 1310115006325 active site 1310115006326 substrate binding site [chemical binding]; other site 1310115006327 CoA binding site [chemical binding]; other site 1310115006328 hypothetical protein; Provisional; Region: PRK14851 1310115006329 hypothetical protein; Validated; Region: PRK08223 1310115006330 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 1310115006331 ATP binding site [chemical binding]; other site 1310115006332 substrate interface [chemical binding]; other site 1310115006333 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1310115006334 PE family; Region: PE; pfam00934 1310115006335 potential frameshift: common BLAST hit: gi|471338326|ref|YP_007611039.1| DNA primase 1310115006336 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 1310115006337 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1310115006338 Zn2+ binding site [ion binding]; other site 1310115006339 Mg2+ binding site [ion binding]; other site 1310115006340 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1310115006341 Repair protein; Region: Repair_PSII; pfam04536 1310115006342 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1310115006343 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1310115006344 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 1310115006345 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1310115006346 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 1310115006347 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1310115006348 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 1310115006349 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1310115006350 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115006351 PPE family; Region: PPE; pfam00823 1310115006352 PPE family; Region: PPE; pfam00823 1310115006353 PPE family; Region: PPE; pfam00823 1310115006354 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1310115006355 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1310115006356 motif 1; other site 1310115006357 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1310115006358 active site 1310115006359 motif 2; other site 1310115006360 motif 3; other site 1310115006361 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1310115006362 anticodon binding site; other site 1310115006363 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1310115006364 dimerization interface [polypeptide binding]; other site 1310115006365 putative DNA binding site [nucleotide binding]; other site 1310115006366 putative Zn2+ binding site [ion binding]; other site 1310115006367 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1310115006368 metal binding site 2 [ion binding]; metal-binding site 1310115006369 putative DNA binding helix; other site 1310115006370 metal binding site 1 [ion binding]; metal-binding site 1310115006371 dimer interface [polypeptide binding]; other site 1310115006372 structural Zn2+ binding site [ion binding]; other site 1310115006373 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1310115006374 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1310115006375 catalytic residue [active] 1310115006376 putative FPP diphosphate binding site; other site 1310115006377 putative FPP binding hydrophobic cleft; other site 1310115006378 dimer interface [polypeptide binding]; other site 1310115006379 putative IPP diphosphate binding site; other site 1310115006380 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1310115006381 Recombination protein O N terminal; Region: RecO_N; pfam11967 1310115006382 Recombination protein O C terminal; Region: RecO_C; pfam02565 1310115006383 amidase; Provisional; Region: PRK06061 1310115006384 Amidase; Region: Amidase; pfam01425 1310115006385 GTPase Era; Reviewed; Region: era; PRK00089 1310115006386 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1310115006387 G1 box; other site 1310115006388 GTP/Mg2+ binding site [chemical binding]; other site 1310115006389 Switch I region; other site 1310115006390 G2 box; other site 1310115006391 Switch II region; other site 1310115006392 G3 box; other site 1310115006393 G4 box; other site 1310115006394 G5 box; other site 1310115006395 KH domain; Region: KH_2; pfam07650 1310115006396 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1310115006397 Domain of unknown function DUF21; Region: DUF21; pfam01595 1310115006398 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1310115006399 Transporter associated domain; Region: CorC_HlyC; smart01091 1310115006400 metal-binding heat shock protein; Provisional; Region: PRK00016 1310115006401 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 1310115006402 K homology RNA-binding domain; Region: KH; smart00322 1310115006403 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1310115006404 PhoH-like protein; Region: PhoH; pfam02562 1310115006405 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1310115006406 PE family; Region: PE; pfam00934 1310115006407 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1310115006408 RNA methyltransferase, RsmE family; Region: TIGR00046 1310115006409 chaperone protein DnaJ; Provisional; Region: PRK14278 1310115006410 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1310115006411 HSP70 interaction site [polypeptide binding]; other site 1310115006412 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1310115006413 Zn binding sites [ion binding]; other site 1310115006414 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1310115006415 dimer interface [polypeptide binding]; other site 1310115006416 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1310115006417 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1310115006418 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 1310115006419 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1310115006420 Condensation domain; Region: Condensation; pfam00668 1310115006421 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1310115006422 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1310115006423 acyl-activating enzyme (AAE) consensus motif; other site 1310115006424 AMP binding site [chemical binding]; other site 1310115006425 Condensation domain; Region: Condensation; pfam00668 1310115006426 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1310115006427 Condensation domain; Region: Condensation; pfam00668 1310115006428 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1310115006429 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1310115006430 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1310115006431 acyl-activating enzyme (AAE) consensus motif; other site 1310115006432 AMP binding site [chemical binding]; other site 1310115006433 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1310115006434 Condensation domain; Region: Condensation; pfam00668 1310115006435 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1310115006436 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1310115006437 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1310115006438 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1310115006439 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1310115006440 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1310115006441 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 1310115006442 NADP binding site [chemical binding]; other site 1310115006443 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1310115006444 active site 1310115006445 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1310115006446 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1310115006447 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1310115006448 active site 1310115006449 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1310115006450 Condensation domain; Region: Condensation; pfam00668 1310115006451 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1310115006452 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1310115006453 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 1310115006454 acyl-activating enzyme (AAE) consensus motif; other site 1310115006455 AMP binding site [chemical binding]; other site 1310115006456 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1310115006457 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1310115006458 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 1310115006459 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1310115006460 acyl-activating enzyme (AAE) consensus motif; other site 1310115006461 active site 1310115006462 AMP binding site [chemical binding]; other site 1310115006463 substrate binding site [chemical binding]; other site 1310115006464 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1310115006465 salicylate synthase MbtI; Reviewed; Region: PRK07912 1310115006466 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1310115006467 Predicted permease [General function prediction only]; Region: COG3329 1310115006468 coproporphyrinogen III oxidase; Validated; Region: PRK05628 1310115006469 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1310115006470 potential frameshift: common BLAST hit: gi|449064453|ref|YP_007431536.1| ferredoxin-dependent nitrite reductase NIRA 1310115006471 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1310115006472 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1310115006473 Active Sites [active] 1310115006474 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1310115006475 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1310115006476 putative active site [active] 1310115006477 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1310115006478 putative active site [active] 1310115006479 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1310115006480 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1310115006481 Predicted membrane protein [Function unknown]; Region: COG1297 1310115006482 putative oligopeptide transporter, OPT family; Region: TIGR00733 1310115006483 PE family; Region: PE; pfam00934 1310115006484 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1310115006485 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 1310115006486 Walker A/P-loop; other site 1310115006487 ATP binding site [chemical binding]; other site 1310115006488 Q-loop/lid; other site 1310115006489 ABC transporter signature motif; other site 1310115006490 Walker B; other site 1310115006491 D-loop; other site 1310115006492 H-loop/switch region; other site 1310115006493 sulfate transport protein; Provisional; Region: cysT; CHL00187 1310115006494 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1310115006495 dimer interface [polypeptide binding]; other site 1310115006496 conserved gate region; other site 1310115006497 putative PBP binding loops; other site 1310115006498 ABC-ATPase subunit interface; other site 1310115006499 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1310115006500 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1310115006501 dimer interface [polypeptide binding]; other site 1310115006502 conserved gate region; other site 1310115006503 putative PBP binding loops; other site 1310115006504 ABC-ATPase subunit interface; other site 1310115006505 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 1310115006506 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1310115006507 PknH-like extracellular domain; Region: PknH_C; pfam14032 1310115006508 GTP-binding protein LepA; Provisional; Region: PRK05433 1310115006509 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1310115006510 G1 box; other site 1310115006511 putative GEF interaction site [polypeptide binding]; other site 1310115006512 GTP/Mg2+ binding site [chemical binding]; other site 1310115006513 Switch I region; other site 1310115006514 G2 box; other site 1310115006515 G3 box; other site 1310115006516 Switch II region; other site 1310115006517 G4 box; other site 1310115006518 G5 box; other site 1310115006519 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1310115006520 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1310115006521 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1310115006522 PemK-like protein; Region: PemK; pfam02452 1310115006523 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 1310115006524 FOG: CBS domain [General function prediction only]; Region: COG0517 1310115006525 ribonuclease Z; Reviewed; Region: PRK00055 1310115006526 PE family; Region: PE; pfam00934 1310115006527 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1310115006528 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1310115006529 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1310115006530 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1310115006531 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1310115006532 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1310115006533 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1310115006534 hypothetical protein; Reviewed; Region: PRK07914 1310115006535 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1310115006536 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1310115006537 Competence protein; Region: Competence; pfam03772 1310115006538 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1310115006539 Helix-hairpin-helix motif; Region: HHH; pfam00633 1310115006540 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 1310115006541 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1310115006542 Coenzyme A binding pocket [chemical binding]; other site 1310115006543 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 1310115006544 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1310115006545 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1310115006546 active site 1310115006547 catalytic triad [active] 1310115006548 oxyanion hole [active] 1310115006549 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1310115006550 catalytic core [active] 1310115006551 Oligomerisation domain; Region: Oligomerisation; cl00519 1310115006552 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1310115006553 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1310115006554 active site 1310115006555 (T/H)XGH motif; other site 1310115006556 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1310115006557 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310115006558 S-adenosylmethionine binding site [chemical binding]; other site 1310115006559 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1310115006560 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1310115006561 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 1310115006562 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1310115006563 metal ion-dependent adhesion site (MIDAS); other site 1310115006564 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1310115006565 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1310115006566 Walker A motif; other site 1310115006567 ATP binding site [chemical binding]; other site 1310115006568 Walker B motif; other site 1310115006569 arginine finger; other site 1310115006570 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1310115006571 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1310115006572 putative catalytic cysteine [active] 1310115006573 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1310115006574 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1310115006575 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1310115006576 dimer interface [polypeptide binding]; other site 1310115006577 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1310115006578 catalytic triad [active] 1310115006579 peroxidatic and resolving cysteines [active] 1310115006580 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 1310115006581 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 1310115006582 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115006583 PPE family; Region: PPE; pfam00823 1310115006584 PE family; Region: PE; pfam00934 1310115006585 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1310115006586 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1310115006587 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1310115006588 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1310115006589 ligand binding site [chemical binding]; other site 1310115006590 flexible hinge region; other site 1310115006591 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1310115006592 dimerization interface [polypeptide binding]; other site 1310115006593 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1310115006594 cyclase homology domain; Region: CHD; cd07302 1310115006595 nucleotidyl binding site; other site 1310115006596 metal binding site [ion binding]; metal-binding site 1310115006597 dimer interface [polypeptide binding]; other site 1310115006598 alpha-dioxygenase; Region: PLN02283 1310115006599 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1310115006600 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1310115006601 substrate binding site [chemical binding]; other site 1310115006602 dimer interface [polypeptide binding]; other site 1310115006603 ATP binding site [chemical binding]; other site 1310115006604 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1310115006605 NAD synthetase; Reviewed; Region: nadE; PRK02628 1310115006606 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1310115006607 multimer interface [polypeptide binding]; other site 1310115006608 active site 1310115006609 catalytic triad [active] 1310115006610 protein interface 1 [polypeptide binding]; other site 1310115006611 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1310115006612 homodimer interface [polypeptide binding]; other site 1310115006613 NAD binding pocket [chemical binding]; other site 1310115006614 ATP binding pocket [chemical binding]; other site 1310115006615 Mg binding site [ion binding]; other site 1310115006616 active-site loop [active] 1310115006617 gamma-glutamyl kinase; Provisional; Region: PRK05429 1310115006618 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1310115006619 nucleotide binding site [chemical binding]; other site 1310115006620 homotetrameric interface [polypeptide binding]; other site 1310115006621 putative phosphate binding site [ion binding]; other site 1310115006622 putative allosteric binding site; other site 1310115006623 PUA domain; Region: PUA; pfam01472 1310115006624 GTPase CgtA; Reviewed; Region: obgE; PRK12296 1310115006625 GTP1/OBG; Region: GTP1_OBG; pfam01018 1310115006626 Obg GTPase; Region: Obg; cd01898 1310115006627 G1 box; other site 1310115006628 GTP/Mg2+ binding site [chemical binding]; other site 1310115006629 Switch I region; other site 1310115006630 G2 box; other site 1310115006631 G3 box; other site 1310115006632 Switch II region; other site 1310115006633 G4 box; other site 1310115006634 G5 box; other site 1310115006635 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1310115006636 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1310115006637 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1310115006638 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1310115006639 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1310115006640 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1310115006641 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1310115006642 homodimer interface [polypeptide binding]; other site 1310115006643 oligonucleotide binding site [chemical binding]; other site 1310115006644 Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are...; Region: NDPk; cl00335 1310115006645 multimer interface [polypeptide binding]; other site 1310115006646 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 1310115006647 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1310115006648 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1310115006649 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1310115006650 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1310115006651 active site 1310115006652 HIGH motif; other site 1310115006653 nucleotide binding site [chemical binding]; other site 1310115006654 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1310115006655 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1310115006656 active site 1310115006657 KMSKS motif; other site 1310115006658 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1310115006659 tRNA binding surface [nucleotide binding]; other site 1310115006660 anticodon binding site; other site 1310115006661 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1310115006662 Uncharacterized conserved protein [Function unknown]; Region: COG3268 1310115006663 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1310115006664 NAD(P) binding pocket [chemical binding]; other site 1310115006665 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1310115006666 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1310115006667 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 1310115006668 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 1310115006669 TPP-binding site [chemical binding]; other site 1310115006670 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1310115006671 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 1310115006672 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1310115006673 dimer interface [polypeptide binding]; other site 1310115006674 PYR/PP interface [polypeptide binding]; other site 1310115006675 TPP binding site [chemical binding]; other site 1310115006676 substrate binding site [chemical binding]; other site 1310115006677 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1310115006678 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1310115006679 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1310115006680 Walker A motif; other site 1310115006681 ATP binding site [chemical binding]; other site 1310115006682 Walker B motif; other site 1310115006683 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1310115006684 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 1310115006685 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1310115006686 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1310115006687 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310115006688 putative substrate translocation pore; other site 1310115006689 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310115006690 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1310115006691 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1310115006692 oligomer interface [polypeptide binding]; other site 1310115006693 active site residues [active] 1310115006694 Clp protease; Region: CLP_protease; pfam00574 1310115006695 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1310115006696 oligomer interface [polypeptide binding]; other site 1310115006697 active site residues [active] 1310115006698 trigger factor; Provisional; Region: tig; PRK01490 1310115006699 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1310115006700 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1310115006701 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1310115006702 Beta-lactamase; Region: Beta-lactamase; pfam00144 1310115006703 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1310115006704 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 1310115006705 putative DNA binding site [nucleotide binding]; other site 1310115006706 catalytic residue [active] 1310115006707 putative H2TH interface [polypeptide binding]; other site 1310115006708 putative catalytic residues [active] 1310115006709 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1310115006710 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1310115006711 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1310115006712 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1310115006713 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1310115006714 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 1310115006715 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 1310115006716 Zn binding site [ion binding]; other site 1310115006717 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1310115006718 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1310115006719 active site 1310115006720 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1310115006721 apolar tunnel; other site 1310115006722 heme binding site [chemical binding]; other site 1310115006723 dimerization interface [polypeptide binding]; other site 1310115006724 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 1310115006725 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1310115006726 active site 1310115006727 catalytic site [active] 1310115006728 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1310115006729 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1310115006730 active site 1310115006731 NAD-specific glutamate dehydrogenase [Amino acid transport and metabolism]; Region: COG2902 1310115006732 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1310115006733 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1310115006734 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1310115006735 ABC transporter; Region: ABC_tran_2; pfam12848 1310115006736 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1310115006737 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1310115006738 dimer interface [polypeptide binding]; other site 1310115006739 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1310115006740 ssDNA binding site [nucleotide binding]; other site 1310115006741 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1310115006742 glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355 1310115006743 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1310115006744 putative acyl-acceptor binding pocket; other site 1310115006745 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1310115006746 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 1310115006747 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1310115006748 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1310115006749 putative acyl-acceptor binding pocket; other site 1310115006750 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1310115006751 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1310115006752 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1310115006753 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1310115006754 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1310115006755 enoyl-CoA hydratase; Provisional; Region: PRK05870 1310115006756 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1310115006757 substrate binding site [chemical binding]; other site 1310115006758 oxyanion hole (OAH) forming residues; other site 1310115006759 trimer interface [polypeptide binding]; other site 1310115006760 PE family; Region: PE; pfam00934 1310115006761 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1310115006762 cyclase homology domain; Region: CHD; cd07302 1310115006763 nucleotidyl binding site; other site 1310115006764 metal binding site [ion binding]; metal-binding site 1310115006765 dimer interface [polypeptide binding]; other site 1310115006766 Predicted ATPase [General function prediction only]; Region: COG3903 1310115006767 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1310115006768 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1310115006769 DNA binding residues [nucleotide binding] 1310115006770 dimerization interface [polypeptide binding]; other site 1310115006771 PE family; Region: PE; pfam00934 1310115006772 TIGR00725 family protein; Region: TIGR00725 1310115006773 thymidylate synthase; Provisional; Region: thyA; PRK00956 1310115006774 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1310115006775 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1310115006776 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1310115006777 E3 interaction surface; other site 1310115006778 lipoyl attachment site [posttranslational modification]; other site 1310115006779 e3 binding domain; Region: E3_binding; pfam02817 1310115006780 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1310115006781 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1310115006782 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1310115006783 alpha subunit interface [polypeptide binding]; other site 1310115006784 TPP binding site [chemical binding]; other site 1310115006785 heterodimer interface [polypeptide binding]; other site 1310115006786 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1310115006787 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1310115006788 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1310115006789 tetramer interface [polypeptide binding]; other site 1310115006790 TPP-binding site [chemical binding]; other site 1310115006791 heterodimer interface [polypeptide binding]; other site 1310115006792 phosphorylation loop region [posttranslational modification] 1310115006793 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1310115006794 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 1310115006795 putative active site [active] 1310115006796 putative catalytic site [active] 1310115006797 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1310115006798 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1310115006799 active site 1310115006800 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1310115006801 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1310115006802 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1310115006803 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1310115006804 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1310115006805 carboxyltransferase (CT) interaction site; other site 1310115006806 biotinylation site [posttranslational modification]; other site 1310115006807 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1310115006808 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1310115006809 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1310115006810 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1310115006811 potential frameshift: common BLAST hit: gi|471338504|ref|YP_007611217.1| succinyl-CoA:3-ketoacid-coenzyme A transferasesubunit alpha 1310115006812 AMP-binding domain protein; Validated; Region: PRK08315 1310115006813 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1310115006814 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1310115006815 acyl-activating enzyme (AAE) consensus motif; other site 1310115006816 acyl-activating enzyme (AAE) consensus motif; other site 1310115006817 putative AMP binding site [chemical binding]; other site 1310115006818 putative active site [active] 1310115006819 putative CoA binding site [chemical binding]; other site 1310115006820 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310115006821 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310115006822 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1310115006823 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1310115006824 classical (c) SDRs; Region: SDR_c; cd05233 1310115006825 NAD(P) binding site [chemical binding]; other site 1310115006826 active site 1310115006827 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 1310115006828 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1310115006829 catalytic site [active] 1310115006830 putative active site [active] 1310115006831 putative substrate binding site [chemical binding]; other site 1310115006832 dimer interface [polypeptide binding]; other site 1310115006833 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1310115006834 MULE transposase domain; Region: MULE; pfam10551 1310115006835 Domain of unknown function (DUF4411); Region: DUF4411; pfam14367 1310115006836 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1310115006837 non-specific DNA binding site [nucleotide binding]; other site 1310115006838 salt bridge; other site 1310115006839 sequence-specific DNA binding site [nucleotide binding]; other site 1310115006840 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 1310115006841 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1310115006842 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1310115006843 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1310115006844 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1310115006845 PE family; Region: PE; pfam00934 1310115006846 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 1310115006847 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1310115006848 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1310115006849 catalytic triad [active] 1310115006850 hypothetical protein; Provisional; Region: PRK07907 1310115006851 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 1310115006852 active site 1310115006853 metal binding site [ion binding]; metal-binding site 1310115006854 dimer interface [polypeptide binding]; other site 1310115006855 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1310115006856 potential frameshift: common BLAST hit: gi|471338525|ref|YP_007611238.1| fatty acid synthase 1310115006857 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1310115006858 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 1310115006859 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1310115006860 phosphate binding site [ion binding]; other site 1310115006861 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 1310115006862 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 1310115006863 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1310115006864 putative active site [active] 1310115006865 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 1310115006866 Mrr N-terminal domain; Region: Mrr_N; pfam14338 1310115006867 Restriction endonuclease; Region: Mrr_cat; pfam04471 1310115006868 ERCC4 domain; Region: ERCC4; pfam02732 1310115006869 Lsr2; Region: Lsr2; pfam11774 1310115006870 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1310115006871 putative active site [active] 1310115006872 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1310115006873 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1310115006874 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1310115006875 catalytic residue [active] 1310115006876 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1310115006877 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1310115006878 putative RNA binding site [nucleotide binding]; other site 1310115006879 elongation factor P; Validated; Region: PRK00529 1310115006880 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1310115006881 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1310115006882 RNA binding site [nucleotide binding]; other site 1310115006883 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1310115006884 RNA binding site [nucleotide binding]; other site 1310115006885 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1310115006886 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1310115006887 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1310115006888 active site 1310115006889 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1310115006890 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1310115006891 trimer interface [polypeptide binding]; other site 1310115006892 active site 1310115006893 dimer interface [polypeptide binding]; other site 1310115006894 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1310115006895 active site 1310115006896 dimer interface [polypeptide binding]; other site 1310115006897 metal binding site [ion binding]; metal-binding site 1310115006898 shikimate kinase; Reviewed; Region: aroK; PRK00131 1310115006899 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1310115006900 ADP binding site [chemical binding]; other site 1310115006901 magnesium binding site [ion binding]; other site 1310115006902 putative shikimate binding site; other site 1310115006903 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1310115006904 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1310115006905 Tetramer interface [polypeptide binding]; other site 1310115006906 active site 1310115006907 FMN-binding site [chemical binding]; other site 1310115006908 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1310115006909 digalactosyldiacylglycerol synthase; Region: PLN02846 1310115006910 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1310115006911 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1310115006912 putative active site [active] 1310115006913 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1310115006914 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1310115006915 oligomeric interface; other site 1310115006916 putative active site [active] 1310115006917 homodimer interface [polypeptide binding]; other site 1310115006918 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1310115006919 putative active site [active] 1310115006920 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1310115006921 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1310115006922 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1310115006923 shikimate-5-dehydrogenase, fungal AROM-type; Region: Shik-DH-AROM; TIGR01809 1310115006924 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1310115006925 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1310115006926 NAD(P) binding site [chemical binding]; other site 1310115006927 shikimate binding site; other site 1310115006928 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 1310115006929 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1310115006930 dimerization interface [polypeptide binding]; other site 1310115006931 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1310115006932 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1310115006933 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1310115006934 motif 1; other site 1310115006935 active site 1310115006936 motif 2; other site 1310115006937 motif 3; other site 1310115006938 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1310115006939 DHHA1 domain; Region: DHHA1; pfam02272 1310115006940 Uncharacterized conserved protein [Function unknown]; Region: COG0432 1310115006941 potential frameshift: common BLAST hit: gi|449064636|ref|YP_007431719.1| recombination factor protein RarA 1310115006942 Predicted integral membrane protein [Function unknown]; Region: COG5473 1310115006943 Protein of unknown function (DUF2652); Region: DUF2652; pfam10851 1310115006944 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1310115006945 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1310115006946 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1310115006947 Walker A/P-loop; other site 1310115006948 ATP binding site [chemical binding]; other site 1310115006949 Q-loop/lid; other site 1310115006950 ABC transporter signature motif; other site 1310115006951 Walker B; other site 1310115006952 D-loop; other site 1310115006953 H-loop/switch region; other site 1310115006954 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1310115006955 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1310115006956 ligand binding site [chemical binding]; other site 1310115006957 flexible hinge region; other site 1310115006958 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1310115006959 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1310115006960 ligand binding site [chemical binding]; other site 1310115006961 flexible hinge region; other site 1310115006962 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1310115006963 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 1310115006964 active site 1310115006965 nucleophile elbow; other site 1310115006966 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1310115006967 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1310115006968 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1310115006969 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 1310115006970 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 1310115006971 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1310115006972 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1310115006973 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1310115006974 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 1310115006975 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 1310115006976 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1310115006977 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1310115006978 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1310115006979 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3801 1310115006980 Predicted membrane protein [Function unknown]; Region: COG4129 1310115006981 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1310115006982 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1310115006983 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1310115006984 dimer interface [polypeptide binding]; other site 1310115006985 anticodon binding site; other site 1310115006986 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1310115006987 homodimer interface [polypeptide binding]; other site 1310115006988 motif 1; other site 1310115006989 active site 1310115006990 motif 2; other site 1310115006991 GAD domain; Region: GAD; pfam02938 1310115006992 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1310115006993 active site 1310115006994 motif 3; other site 1310115006995 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1310115006996 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1310115006997 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1310115006998 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1310115006999 putative hydrophobic ligand binding site [chemical binding]; other site 1310115007000 protein interface [polypeptide binding]; other site 1310115007001 gate; other site 1310115007002 Predicted metalloprotease [General function prediction only]; Region: COG2321 1310115007003 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1310115007004 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1310115007005 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1310115007006 active site 1310115007007 metal binding site [ion binding]; metal-binding site 1310115007008 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1310115007009 haloalkane dehalogenase; Provisional; Region: PRK03592 1310115007010 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1310115007011 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1310115007012 dimer interface [polypeptide binding]; other site 1310115007013 motif 1; other site 1310115007014 active site 1310115007015 motif 2; other site 1310115007016 motif 3; other site 1310115007017 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1310115007018 anticodon binding site; other site 1310115007019 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1310115007020 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1310115007021 active site 1310115007022 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 1310115007023 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1310115007024 Zn2+ binding site [ion binding]; other site 1310115007025 Mg2+ binding site [ion binding]; other site 1310115007026 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1310115007027 synthetase active site [active] 1310115007028 NTP binding site [chemical binding]; other site 1310115007029 metal binding site [ion binding]; metal-binding site 1310115007030 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1310115007031 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1310115007032 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1310115007033 active site 1310115007034 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1310115007035 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1310115007036 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1310115007037 Protein export membrane protein; Region: SecD_SecF; pfam02355 1310115007038 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1310115007039 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1310115007040 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05886 1310115007041 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 1310115007042 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1310115007043 inhibitor-cofactor binding pocket; inhibition site 1310115007044 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310115007045 catalytic residue [active] 1310115007046 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1310115007047 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1310115007048 acyl-activating enzyme (AAE) consensus motif; other site 1310115007049 AMP binding site [chemical binding]; other site 1310115007050 active site 1310115007051 CoA binding site [chemical binding]; other site 1310115007052 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 1310115007053 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1310115007054 putative NAD(P) binding site [chemical binding]; other site 1310115007055 active site 1310115007056 putative substrate binding site [chemical binding]; other site 1310115007057 PE family; Region: PE; pfam00934 1310115007058 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1310115007059 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1310115007060 Walker A motif; other site 1310115007061 ATP binding site [chemical binding]; other site 1310115007062 Walker B motif; other site 1310115007063 arginine finger; other site 1310115007064 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1310115007065 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1310115007066 RuvA N terminal domain; Region: RuvA_N; pfam01330 1310115007067 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1310115007068 active site 1310115007069 putative DNA-binding cleft [nucleotide binding]; other site 1310115007070 dimer interface [polypeptide binding]; other site 1310115007071 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1310115007072 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 1310115007073 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1310115007074 putative active site [active] 1310115007075 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 1310115007076 Protein of unknown function DUF2617; Region: DUF2617; pfam10936 1310115007077 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 1310115007078 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1310115007079 Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only]; Region: COG4262 1310115007080 Spermine/spermidine synthase; Region: Spermine_synth; pfam01564 1310115007081 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 1310115007082 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1310115007083 hypothetical protein; Validated; Region: PRK00110 1310115007084 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1310115007085 predicted active site [active] 1310115007086 catalytic triad [active] 1310115007087 acyl-CoA thioesterase II; Region: tesB; TIGR00189 1310115007088 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1310115007089 active site 1310115007090 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1310115007091 catalytic triad [active] 1310115007092 dimer interface [polypeptide binding]; other site 1310115007093 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1310115007094 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1310115007095 active site 1310115007096 multimer interface [polypeptide binding]; other site 1310115007097 Pyridoxamine-phosphate oxidase [Coenzyme metabolism]; Region: PdxH; COG0259 1310115007098 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1310115007099 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1310115007100 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115007101 PPE family; Region: PPE; pfam00823 1310115007102 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115007103 PE-PPE domain; Region: PE-PPE; pfam08237 1310115007104 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 1310115007105 nudix motif; other site 1310115007106 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1310115007107 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1310115007108 potential frameshift: common BLAST hit: gi|385991914|ref|YP_005910212.1| lipid A biosynthesis lauroyl acyltransferase 1310115007109 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1310115007110 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 1310115007111 nucleotide binding site/active site [active] 1310115007112 HIT family signature motif; other site 1310115007113 catalytic residue [active] 1310115007114 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 1310115007115 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1310115007116 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1310115007117 active site 1310115007118 dimer interface [polypeptide binding]; other site 1310115007119 motif 1; other site 1310115007120 motif 2; other site 1310115007121 motif 3; other site 1310115007122 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1310115007123 anticodon binding site; other site 1310115007124 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1310115007125 phosphate binding site [ion binding]; other site 1310115007126 PE family; Region: PE; pfam00934 1310115007127 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4762 1310115007128 Predicted transcriptional regulator [Transcription]; Region: COG2345 1310115007129 Helix-turn-helix domain; Region: HTH_20; pfam12840 1310115007130 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1310115007131 Predicted transcriptional regulator [Transcription]; Region: COG2345 1310115007132 Helix-turn-helix domain; Region: HTH_20; pfam12840 1310115007133 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310115007134 S-adenosylmethionine binding site [chemical binding]; other site 1310115007135 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1310115007136 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1310115007137 Ligand Binding Site [chemical binding]; other site 1310115007138 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1310115007139 Ligand Binding Site [chemical binding]; other site 1310115007140 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1310115007141 Ligand Binding Site [chemical binding]; other site 1310115007142 Universal stress protein family; Region: Usp; pfam00582 1310115007143 Ligand Binding Site [chemical binding]; other site 1310115007144 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 1310115007145 active site 1310115007146 Peptidase family M50; Region: Peptidase_M50; pfam02163 1310115007147 putative substrate binding region [chemical binding]; other site 1310115007148 FOG: CBS domain [General function prediction only]; Region: COG0517 1310115007149 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 1310115007150 FOG: CBS domain [General function prediction only]; Region: COG0517 1310115007151 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1310115007152 peptide chain release factor 1; Provisional; Region: PRK04011 1310115007153 SHS2 domain protein implicated in nucleic acid metabolism [General function prediction only]; Region: COG1371 1310115007154 Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690 1310115007155 hypothetical protein; Reviewed; Region: PRK09588 1310115007156 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 1310115007157 Hemerythrin-like domain; Region: Hr-like; cd12108 1310115007158 Fe binding site [ion binding]; other site 1310115007159 PE family; Region: PE; pfam00934 1310115007160 Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cd00227 1310115007161 P-loop motif; other site 1310115007162 ATP binding site [chemical binding]; other site 1310115007163 Chloramphenicol (Cm) binding site [chemical binding]; other site 1310115007164 catalytic residue [active] 1310115007165 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1310115007166 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1310115007167 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1310115007168 anti sigma factor interaction site; other site 1310115007169 regulatory phosphorylation site [posttranslational modification]; other site 1310115007170 hypothetical protein; Provisional; Region: PRK02237 1310115007171 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1310115007172 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1310115007173 putative DNA binding site [nucleotide binding]; other site 1310115007174 putative Zn2+ binding site [ion binding]; other site 1310115007175 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 1310115007176 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1310115007177 putative metal binding site [ion binding]; other site 1310115007178 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1310115007179 dimerization interface [polypeptide binding]; other site 1310115007180 putative DNA binding site [nucleotide binding]; other site 1310115007181 putative Zn2+ binding site [ion binding]; other site 1310115007182 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1310115007183 arsenical-resistance protein; Region: acr3; TIGR00832 1310115007184 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1310115007185 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1310115007186 active site 1310115007187 Protein of unknown function (DUF3018); Region: DUF3018; pfam11455 1310115007188 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1310115007189 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 1310115007190 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1310115007191 Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653 1310115007192 Phage capsid family; Region: Phage_capsid; pfam05065 1310115007193 Phage head maturation protease [General function prediction only]; Region: COG3740 1310115007194 Phage terminase, small subunit; Region: Terminase_4; cl01525 1310115007195 Protein of unknown function (DUF3631); Region: DUF3631; pfam12307 1310115007196 Protein of unknown function (DUF2742); Region: DUF2742; pfam10888 1310115007197 DNA binding domain, excisionase family; Region: excise; TIGR01764 1310115007198 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1310115007199 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1310115007200 active site 1310115007201 catalytic residues [active] 1310115007202 DNA binding site [nucleotide binding] 1310115007203 Int/Topo IB signature motif; other site 1310115007204 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1310115007205 MULE transposase domain; Region: MULE; pfam10551 1310115007206 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1310115007207 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1310115007208 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1310115007209 Coenzyme A binding pocket [chemical binding]; other site 1310115007210 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 1310115007211 hypothetical protein; Provisional; Region: PRK14059 1310115007212 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1310115007213 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1310115007214 TAP-like protein; Region: Abhydrolase_4; pfam08386 1310115007215 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1310115007216 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 1310115007217 SelR domain; Region: SelR; pfam01641 1310115007218 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1310115007219 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310115007220 S-adenosylmethionine binding site [chemical binding]; other site 1310115007221 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 1310115007222 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1310115007223 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1310115007224 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1310115007225 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1310115007226 substrate binding site [chemical binding]; other site 1310115007227 active site 1310115007228 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1310115007229 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1310115007230 substrate binding site [chemical binding]; other site 1310115007231 oxyanion hole (OAH) forming residues; other site 1310115007232 trimer interface [polypeptide binding]; other site 1310115007233 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 1310115007234 potential frameshift: common BLAST hit: gi|397674590|ref|YP_006516125.1| ribonuclease D 1310115007235 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 1310115007236 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1310115007237 TPP-binding site; other site 1310115007238 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1310115007239 PYR/PP interface [polypeptide binding]; other site 1310115007240 dimer interface [polypeptide binding]; other site 1310115007241 TPP binding site [chemical binding]; other site 1310115007242 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1310115007243 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1310115007244 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1310115007245 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 1310115007246 transmembrane helices; other site 1310115007247 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1310115007248 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 1310115007249 transmembrane helices; other site 1310115007250 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1310115007251 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1310115007252 Walker A/P-loop; other site 1310115007253 ATP binding site [chemical binding]; other site 1310115007254 Q-loop/lid; other site 1310115007255 ABC transporter signature motif; other site 1310115007256 Walker B; other site 1310115007257 D-loop; other site 1310115007258 H-loop/switch region; other site 1310115007259 TRAM domain; Region: TRAM; cl01282 1310115007260 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1310115007261 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1310115007262 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1310115007263 TrkA-N domain; Region: TrkA_N; pfam02254 1310115007264 TrkA-C domain; Region: TrkA_C; pfam02080 1310115007265 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1310115007266 TrkA-N domain; Region: TrkA_N; pfam02254 1310115007267 TrkA-C domain; Region: TrkA_C; pfam02080 1310115007268 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 1310115007269 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1310115007270 generic binding surface II; other site 1310115007271 ssDNA binding site; other site 1310115007272 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 1310115007273 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1310115007274 trimer interface [polypeptide binding]; other site 1310115007275 active site 1310115007276 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 1310115007277 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 1310115007278 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1310115007279 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1310115007280 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1310115007281 active site 1310115007282 dimerization interface [polypeptide binding]; other site 1310115007283 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1310115007284 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1310115007285 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1310115007286 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1310115007287 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1310115007288 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1310115007289 DNA binding residues [nucleotide binding] 1310115007290 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 1310115007291 homotrimer interaction site [polypeptide binding]; other site 1310115007292 putative active site [active] 1310115007293 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502 1310115007294 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 1310115007295 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 1310115007296 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 1310115007297 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1310115007298 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1310115007299 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1310115007300 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1310115007301 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1310115007302 DNA binding residues [nucleotide binding] 1310115007303 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1310115007304 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1310115007305 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1310115007306 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 1310115007307 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 1310115007308 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 1310115007309 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1310115007310 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1310115007311 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1310115007312 PAC2 family; Region: PAC2; pfam09754 1310115007313 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1310115007314 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1310115007315 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1310115007316 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 1310115007317 heme-binding site [chemical binding]; other site 1310115007318 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1310115007319 ATP cone domain; Region: ATP-cone; pfam03477 1310115007320 LysM domain; Region: LysM; pfam01476 1310115007321 LexA repressor; Validated; Region: PRK00215 1310115007322 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1310115007323 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1310115007324 Catalytic site [active] 1310115007325 Integral membrane protein TerC family; Region: TerC; cl10468 1310115007326 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1310115007327 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1310115007328 active site 1310115007329 GTPases [General function prediction only]; Region: HflX; COG2262 1310115007330 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1310115007331 HflX GTPase family; Region: HflX; cd01878 1310115007332 G1 box; other site 1310115007333 GTP/Mg2+ binding site [chemical binding]; other site 1310115007334 Switch I region; other site 1310115007335 G2 box; other site 1310115007336 G3 box; other site 1310115007337 Switch II region; other site 1310115007338 G4 box; other site 1310115007339 G5 box; other site 1310115007340 diaminopimelate epimerase; Region: DapF; TIGR00652 1310115007341 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1310115007342 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1310115007343 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1310115007344 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1310115007345 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 1310115007346 active site 1310115007347 metal binding site [ion binding]; metal-binding site 1310115007348 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1310115007349 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1310115007350 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1310115007351 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 1310115007352 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1310115007353 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1310115007354 FeS/SAM binding site; other site 1310115007355 TRAM domain; Region: TRAM; cl01282 1310115007356 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 1310115007357 Uncharacterized protein conserved in bacteria [General function prediction only]; Region: OraA; COG2137 1310115007358 DNA recombination protein RecA; Reviewed; Region: recA; PRK09519 1310115007359 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1310115007360 hexamer interface [polypeptide binding]; other site 1310115007361 Walker A motif; other site 1310115007362 ATP binding site [chemical binding]; other site 1310115007363 Walker B motif; other site 1310115007364 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1310115007365 protein-splicing catalytic site; other site 1310115007366 thioester formation/cholesterol transfer; other site 1310115007367 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 1310115007368 recA bacterial DNA recombination protein; Region: RecA; cl17211 1310115007369 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 1310115007370 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 1310115007371 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1310115007372 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1310115007373 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1310115007374 PE family; Region: PE; pfam00934 1310115007375 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 1310115007376 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1310115007377 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1310115007378 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1310115007379 non-specific DNA binding site [nucleotide binding]; other site 1310115007380 salt bridge; other site 1310115007381 sequence-specific DNA binding site [nucleotide binding]; other site 1310115007382 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1310115007383 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1310115007384 Coenzyme A binding pocket [chemical binding]; other site 1310115007385 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1310115007386 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1310115007387 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 1310115007388 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1310115007389 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 1310115007390 classical (c) SDRs; Region: SDR_c; cd05233 1310115007391 NAD(P) binding site [chemical binding]; other site 1310115007392 active site 1310115007393 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1310115007394 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1310115007395 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1310115007396 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1310115007397 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1310115007398 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1310115007399 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1310115007400 dimer interface [polypeptide binding]; other site 1310115007401 active site 1310115007402 catalytic residue [active] 1310115007403 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 1310115007404 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1310115007405 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1310115007406 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1310115007407 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1310115007408 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1310115007409 putative active site [active] 1310115007410 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1310115007411 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 1310115007412 putative active site [active] 1310115007413 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 1310115007414 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1310115007415 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1310115007416 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 1310115007417 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1310115007418 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1310115007419 folate binding site [chemical binding]; other site 1310115007420 NADP+ binding site [chemical binding]; other site 1310115007421 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1310115007422 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1310115007423 dimerization interface [polypeptide binding]; other site 1310115007424 active site 1310115007425 Dienelactone hydrolase family; Region: DLH; pfam01738 1310115007426 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1310115007427 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1310115007428 classical (c) SDRs; Region: SDR_c; cd05233 1310115007429 NAD(P) binding site [chemical binding]; other site 1310115007430 active site 1310115007431 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115007432 PPE family; Region: PPE; pfam00823 1310115007433 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1310115007434 PE family; Region: PE; pfam00934 1310115007435 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1310115007436 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115007437 PPE family; Region: PPE; pfam00823 1310115007438 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1310115007439 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1310115007440 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1310115007441 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1310115007442 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1310115007443 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1310115007444 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1310115007445 Coenzyme A binding pocket [chemical binding]; other site 1310115007446 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1310115007447 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1310115007448 FMN-binding pocket [chemical binding]; other site 1310115007449 flavin binding motif; other site 1310115007450 phosphate binding motif [ion binding]; other site 1310115007451 beta-alpha-beta structure motif; other site 1310115007452 NAD binding pocket [chemical binding]; other site 1310115007453 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1310115007454 catalytic loop [active] 1310115007455 iron binding site [ion binding]; other site 1310115007456 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1310115007457 hydrophobic ligand binding site; other site 1310115007458 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1310115007459 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1310115007460 putative DNA binding site [nucleotide binding]; other site 1310115007461 putative Zn2+ binding site [ion binding]; other site 1310115007462 AsnC family; Region: AsnC_trans_reg; pfam01037 1310115007463 alanine dehydrogenase; Region: alaDH; TIGR00518 1310115007464 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1310115007465 hexamer interface [polypeptide binding]; other site 1310115007466 ligand binding site [chemical binding]; other site 1310115007467 putative active site [active] 1310115007468 NAD(P) binding site [chemical binding]; other site 1310115007469 Nitronate monooxygenase; Region: NMO; pfam03060 1310115007470 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1310115007471 FMN binding site [chemical binding]; other site 1310115007472 substrate binding site [chemical binding]; other site 1310115007473 putative catalytic residue [active] 1310115007474 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1310115007475 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1310115007476 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1310115007477 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 1310115007478 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 1310115007479 oligomer interface [polypeptide binding]; other site 1310115007480 RNA binding site [nucleotide binding]; other site 1310115007481 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1310115007482 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1310115007483 RNase E interface [polypeptide binding]; other site 1310115007484 trimer interface [polypeptide binding]; other site 1310115007485 active site 1310115007486 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1310115007487 putative nucleic acid binding region [nucleotide binding]; other site 1310115007488 G-X-X-G motif; other site 1310115007489 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1310115007490 RNA binding site [nucleotide binding]; other site 1310115007491 domain interface; other site 1310115007492 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1310115007493 16S/18S rRNA binding site [nucleotide binding]; other site 1310115007494 S13e-L30e interaction site [polypeptide binding]; other site 1310115007495 25S rRNA binding site [nucleotide binding]; other site 1310115007496 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1310115007497 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1310115007498 active site 1310115007499 Riboflavin kinase; Region: Flavokinase; pfam01687 1310115007500 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1310115007501 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 1310115007502 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1310115007503 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1310115007504 putative DNA binding site [nucleotide binding]; other site 1310115007505 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1310115007506 FeoA domain; Region: FeoA; pfam04023 1310115007507 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1310115007508 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1310115007509 active site 1310115007510 lipid-transfer protein; Provisional; Region: PRK08256 1310115007511 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1310115007512 active site 1310115007513 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1310115007514 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1310115007515 Probable transposase; Region: OrfB_IS605; pfam01385 1310115007516 potential frameshift: common BLAST hit: gi|471338802|ref|YP_007611515.1| resolvase 1310115007517 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 1310115007518 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1310115007519 RNA binding site [nucleotide binding]; other site 1310115007520 active site 1310115007521 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 1310115007522 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 1310115007523 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1310115007524 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1310115007525 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1310115007526 active site 1310115007527 metal binding site [ion binding]; metal-binding site 1310115007528 Uncharacterized conserved protein [Function unknown]; Region: COG4717 1310115007529 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1310115007530 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1310115007531 Predicted acyl esterases [General function prediction only]; Region: COG2936 1310115007532 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1310115007533 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1310115007534 Uncharacterized conserved protein [Function unknown]; Region: COG5586 1310115007535 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 1310115007536 Integrase core domain; Region: rve; pfam00665 1310115007537 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1310115007538 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1310115007539 Helix-turn-helix domain; Region: HTH_28; pfam13518 1310115007540 Winged helix-turn helix; Region: HTH_29; pfam13551 1310115007541 Integrase core domain; Region: rve; pfam00665 1310115007542 Integrase core domain; Region: rve_3; pfam13683 1310115007543 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 1310115007544 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 1310115007545 putative transposase OrfB; Reviewed; Region: PHA02517 1310115007546 HTH-like domain; Region: HTH_21; pfam13276 1310115007547 Integrase core domain; Region: rve; pfam00665 1310115007548 Integrase core domain; Region: rve_3; pfam13683 1310115007549 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1310115007550 Transposase; Region: HTH_Tnp_1; cl17663 1310115007551 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 1310115007552 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09636 1310115007553 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl09873 1310115007554 CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cd09662 1310115007555 CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cd09663 1310115007556 CRISPR/Cas system-associated RAMP superfamily protein Csm3; Region: Csm3_III-A; cd09684 1310115007557 CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cd09647 1310115007558 Predicted CRISPR-associated polymerase [Defense mechanisms]; Region: COG1353 1310115007559 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 1310115007560 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 1310115007561 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4293 1310115007562 Uncharacterized conserved protein [Function unknown]; Region: COG2253 1310115007563 Protein of unknown function (DUF2005); Region: DUF2005; pfam09407 1310115007564 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4293 1310115007565 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 1310115007566 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 1310115007567 putative active site [active] 1310115007568 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1310115007569 enoyl-CoA hydratase; Provisional; Region: PRK06190 1310115007570 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1310115007571 substrate binding site [chemical binding]; other site 1310115007572 oxyanion hole (OAH) forming residues; other site 1310115007573 trimer interface [polypeptide binding]; other site 1310115007574 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1310115007575 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1310115007576 Walker A/P-loop; other site 1310115007577 ATP binding site [chemical binding]; other site 1310115007578 Q-loop/lid; other site 1310115007579 ABC transporter signature motif; other site 1310115007580 Walker B; other site 1310115007581 D-loop; other site 1310115007582 H-loop/switch region; other site 1310115007583 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1310115007584 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1310115007585 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1310115007586 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1310115007587 dimer interface [polypeptide binding]; other site 1310115007588 conserved gate region; other site 1310115007589 putative PBP binding loops; other site 1310115007590 ABC-ATPase subunit interface; other site 1310115007591 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1310115007592 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1310115007593 dimer interface [polypeptide binding]; other site 1310115007594 conserved gate region; other site 1310115007595 putative PBP binding loops; other site 1310115007596 ABC-ATPase subunit interface; other site 1310115007597 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1310115007598 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1310115007599 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1310115007600 DHH family; Region: DHH; pfam01368 1310115007601 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1310115007602 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1310115007603 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1310115007604 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 1310115007605 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1310115007606 G1 box; other site 1310115007607 putative GEF interaction site [polypeptide binding]; other site 1310115007608 GTP/Mg2+ binding site [chemical binding]; other site 1310115007609 Switch I region; other site 1310115007610 G2 box; other site 1310115007611 G3 box; other site 1310115007612 Switch II region; other site 1310115007613 G4 box; other site 1310115007614 G5 box; other site 1310115007615 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1310115007616 Translation-initiation factor 2; Region: IF-2; pfam11987 1310115007617 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1310115007618 Predicted nucleic-acid-binding protein implicated in transcription termination [Transcription]; Region: COG2740 1310115007619 putative RNA binding cleft [nucleotide binding]; other site 1310115007620 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1310115007621 NusA N-terminal domain; Region: NusA_N; pfam08529 1310115007622 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1310115007623 RNA binding site [nucleotide binding]; other site 1310115007624 homodimer interface [polypeptide binding]; other site 1310115007625 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1310115007626 G-X-X-G motif; other site 1310115007627 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1310115007628 G-X-X-G motif; other site 1310115007629 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1310115007630 Sm and related proteins; Region: Sm_like; cl00259 1310115007631 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1310115007632 putative oligomer interface [polypeptide binding]; other site 1310115007633 putative RNA binding site [nucleotide binding]; other site 1310115007634 Mitochondrial ATP synthase g subunit; Region: ATP-synt_G; pfam04718 1310115007635 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1310115007636 dinuclear metal binding motif [ion binding]; other site 1310115007637 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1310115007638 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1310115007639 dimer interface [polypeptide binding]; other site 1310115007640 motif 1; other site 1310115007641 active site 1310115007642 motif 2; other site 1310115007643 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 1310115007644 putative deacylase active site [active] 1310115007645 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1310115007646 active site 1310115007647 motif 3; other site 1310115007648 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1310115007649 anticodon binding site; other site 1310115007650 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310115007651 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1310115007652 putative substrate translocation pore; other site 1310115007653 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 1310115007654 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1310115007655 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1310115007656 homodimer interface [polypeptide binding]; other site 1310115007657 active site 1310115007658 SAM binding site [chemical binding]; other site 1310115007659 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1310115007660 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1310115007661 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1310115007662 catalytic triad [active] 1310115007663 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1310115007664 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1310115007665 homodimer interface [polypeptide binding]; other site 1310115007666 Walker A motif; other site 1310115007667 ATP binding site [chemical binding]; other site 1310115007668 hydroxycobalamin binding site [chemical binding]; other site 1310115007669 Walker B motif; other site 1310115007670 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 1310115007671 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1310115007672 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 1310115007673 metal ion-dependent adhesion site (MIDAS); other site 1310115007674 Predicted acyltransferase [General function prediction only]; Region: ElaA; COG2153 1310115007675 malate:quinone oxidoreductase; Validated; Region: PRK05257 1310115007676 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1310115007677 PE family; Region: PE; pfam00934 1310115007678 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1310115007679 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1310115007680 mycothione reductase; Reviewed; Region: PRK07846 1310115007681 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1310115007682 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1310115007683 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1310115007684 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 1310115007685 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1310115007686 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1310115007687 short chain dehydrogenase; Provisional; Region: PRK06057 1310115007688 classical (c) SDRs; Region: SDR_c; cd05233 1310115007689 NAD(P) binding site [chemical binding]; other site 1310115007690 active site 1310115007691 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1310115007692 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 1310115007693 NAD(P) binding site [chemical binding]; other site 1310115007694 catalytic residues [active] 1310115007695 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 1310115007696 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1310115007697 catalytic triad [active] 1310115007698 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1310115007699 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1310115007700 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1310115007701 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1310115007702 active site 1310115007703 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1310115007704 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1310115007705 putative active site [active] 1310115007706 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1310115007707 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1310115007708 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1310115007709 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 1310115007710 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1310115007711 Predicted acetyltransferase [General function prediction only]; Region: COG3393 1310115007712 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 1310115007713 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1310115007714 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1310115007715 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1310115007716 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 1310115007717 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1310115007718 active site 1310115007719 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1310115007720 protein binding site [polypeptide binding]; other site 1310115007721 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1310115007722 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1310115007723 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1310115007724 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1310115007725 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1310115007726 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1310115007727 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 1310115007728 Fasciclin domain; Region: Fasciclin; pfam02469 1310115007729 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1310115007730 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1310115007731 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1310115007732 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 1310115007733 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1310115007734 catalytic residues [active] 1310115007735 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 1310115007736 Fasciclin domain; Region: Fasciclin; pfam02469 1310115007737 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 1310115007738 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1310115007739 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 1310115007740 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1310115007741 catalytic residues [active] 1310115007742 potential frameshift: common BLAST hit: gi|386005745|ref|YP_005924024.1| ribosomal RNA large subunit methyltransferase N 1310115007743 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1310115007744 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1310115007745 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1310115007746 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1310115007747 hinge region; other site 1310115007748 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1310115007749 putative nucleotide binding site [chemical binding]; other site 1310115007750 uridine monophosphate binding site [chemical binding]; other site 1310115007751 homohexameric interface [polypeptide binding]; other site 1310115007752 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1310115007753 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1310115007754 DNA binding site [nucleotide binding] 1310115007755 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1310115007756 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1310115007757 Probable transposase; Region: OrfB_IS605; pfam01385 1310115007758 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1310115007759 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 1310115007760 catalytic residues [active] 1310115007761 catalytic nucleophile [active] 1310115007762 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1310115007763 MarR family; Region: MarR; pfam01047 1310115007764 amidase; Provisional; Region: PRK07869 1310115007765 Amidase; Region: Amidase; pfam01425 1310115007766 elongation factor Ts; Provisional; Region: tsf; PRK09377 1310115007767 UBA/TS-N domain; Region: UBA; pfam00627 1310115007768 Elongation factor TS; Region: EF_TS; pfam00889 1310115007769 Elongation factor TS; Region: EF_TS; pfam00889 1310115007770 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1310115007771 rRNA interaction site [nucleotide binding]; other site 1310115007772 S8 interaction site; other site 1310115007773 putative laminin-1 binding site; other site 1310115007774 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1310115007775 Peptidase family M23; Region: Peptidase_M23; pfam01551 1310115007776 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115007777 PPE family; Region: PPE; pfam00823 1310115007778 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1310115007779 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 1310115007780 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1310115007781 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1310115007782 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1310115007783 active site 1310115007784 DNA binding site [nucleotide binding] 1310115007785 Int/Topo IB signature motif; other site 1310115007786 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1310115007787 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1310115007788 FAD binding pocket [chemical binding]; other site 1310115007789 FAD binding motif [chemical binding]; other site 1310115007790 phosphate binding motif [ion binding]; other site 1310115007791 NAD binding pocket [chemical binding]; other site 1310115007792 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 1310115007793 DNA protecting protein DprA; Region: dprA; TIGR00732 1310115007794 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1310115007795 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1310115007796 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1310115007797 Walker A motif; other site 1310115007798 ATP binding site [chemical binding]; other site 1310115007799 Walker B motif; other site 1310115007800 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1310115007801 hypothetical protein; Reviewed; Region: PRK12497 1310115007802 potential frameshift: common BLAST hit: gi|471338923|ref|YP_007611636.1| formate dehydrogenase accessory protein 1310115007803 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 1310115007804 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 1310115007805 putative molybdopterin cofactor binding site [chemical binding]; other site 1310115007806 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 1310115007807 putative molybdopterin cofactor binding site; other site 1310115007808 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 1310115007809 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1310115007810 RNA/DNA hybrid binding site [nucleotide binding]; other site 1310115007811 active site 1310115007812 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1310115007813 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1310115007814 Catalytic site [active] 1310115007815 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1310115007816 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1310115007817 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1310115007818 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1310115007819 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1310115007820 RimM N-terminal domain; Region: RimM; pfam01782 1310115007821 hypothetical protein; Provisional; Region: PRK02821 1310115007822 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1310115007823 G-X-X-G motif; other site 1310115007824 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 1310115007825 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1310115007826 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1310115007827 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1310115007828 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310115007829 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310115007830 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1310115007831 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 1310115007832 active site 1310115007833 putative substrate binding pocket [chemical binding]; other site 1310115007834 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1310115007835 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1310115007836 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1310115007837 active site 1310115007838 ATP binding site [chemical binding]; other site 1310115007839 substrate binding site [chemical binding]; other site 1310115007840 activation loop (A-loop); other site 1310115007841 signal recognition particle protein; Provisional; Region: PRK10867 1310115007842 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1310115007843 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1310115007844 P loop; other site 1310115007845 GTP binding site [chemical binding]; other site 1310115007846 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1310115007847 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1310115007848 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1310115007849 ATP binding site [chemical binding]; other site 1310115007850 putative Mg++ binding site [ion binding]; other site 1310115007851 PII uridylyl-transferase; Provisional; Region: PRK03381 1310115007852 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1310115007853 metal binding triad; other site 1310115007854 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1310115007855 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1310115007856 Zn2+ binding site [ion binding]; other site 1310115007857 Mg2+ binding site [ion binding]; other site 1310115007858 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1310115007859 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1310115007860 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1310115007861 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 1310115007862 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1310115007863 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1310115007864 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1310115007865 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1310115007866 Walker A/P-loop; other site 1310115007867 ATP binding site [chemical binding]; other site 1310115007868 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1310115007869 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1310115007870 ABC transporter signature motif; other site 1310115007871 Walker B; other site 1310115007872 D-loop; other site 1310115007873 H-loop/switch region; other site 1310115007874 acylphosphatase; Provisional; Region: PRK14422 1310115007875 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 1310115007876 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1310115007877 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1310115007878 DNA binding site [nucleotide binding] 1310115007879 catalytic residue [active] 1310115007880 H2TH interface [polypeptide binding]; other site 1310115007881 putative catalytic residues [active] 1310115007882 turnover-facilitating residue; other site 1310115007883 intercalation triad [nucleotide binding]; other site 1310115007884 8OG recognition residue [nucleotide binding]; other site 1310115007885 putative reading head residues; other site 1310115007886 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1310115007887 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1310115007888 ribonuclease III; Reviewed; Region: rnc; PRK00102 1310115007889 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1310115007890 dimerization interface [polypeptide binding]; other site 1310115007891 active site 1310115007892 metal binding site [ion binding]; metal-binding site 1310115007893 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1310115007894 dsRNA binding site [nucleotide binding]; other site 1310115007895 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 1310115007896 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1310115007897 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1310115007898 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1310115007899 acyl-CoA synthetase; Validated; Region: PRK05850 1310115007900 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1310115007901 acyl-activating enzyme (AAE) consensus motif; other site 1310115007902 active site 1310115007903 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1310115007904 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1310115007905 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1310115007906 active site 1310115007907 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 1310115007908 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1310115007909 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 1310115007910 NADP binding site [chemical binding]; other site 1310115007911 KR domain; Region: KR; pfam08659 1310115007912 active site 1310115007913 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1310115007914 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1310115007915 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1310115007916 active site 1310115007917 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1310115007918 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 1310115007919 KR domain; Region: KR; pfam08659 1310115007920 NADP binding site [chemical binding]; other site 1310115007921 active site 1310115007922 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1310115007923 potential frameshift: common BLAST hit: gi|449065013|ref|YP_007432096.1| phenolpthiocerol synthesis type-I polyketide synthase PPSC 1310115007924 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1310115007925 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1310115007926 active site 1310115007927 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1310115007928 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1310115007929 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1310115007930 KR domain; Region: KR; pfam08659 1310115007931 putative NADP binding site [chemical binding]; other site 1310115007932 active site 1310115007933 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1310115007934 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1310115007935 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1310115007936 active site 1310115007937 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1310115007938 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1310115007939 Condensation domain; Region: Condensation; pfam00668 1310115007940 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1310115007941 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1310115007942 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1310115007943 Walker A/P-loop; other site 1310115007944 ATP binding site [chemical binding]; other site 1310115007945 Q-loop/lid; other site 1310115007946 ABC transporter signature motif; other site 1310115007947 Walker B; other site 1310115007948 D-loop; other site 1310115007949 H-loop/switch region; other site 1310115007950 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1310115007951 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 1310115007952 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 1310115007953 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1310115007954 acyltransferase PapA5; Provisional; Region: PRK09294 1310115007955 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1310115007956 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1310115007957 active site 1310115007958 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 1310115007959 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1310115007960 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310115007961 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1310115007962 Enoylreductase; Region: PKS_ER; smart00829 1310115007963 NAD(P) binding site [chemical binding]; other site 1310115007964 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1310115007965 KR domain; Region: KR; pfam08659 1310115007966 putative NADP binding site [chemical binding]; other site 1310115007967 active site 1310115007968 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1310115007969 acyl-CoA synthetase; Validated; Region: PRK05850 1310115007970 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1310115007971 acyl-activating enzyme (AAE) consensus motif; other site 1310115007972 active site 1310115007973 MMPL family; Region: MMPL; pfam03176 1310115007974 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1310115007975 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1310115007976 Integrase core domain; Region: rve; pfam00665 1310115007977 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1310115007978 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1310115007979 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1310115007980 ATP binding site [chemical binding]; other site 1310115007981 Walker A motif; other site 1310115007982 Walker B motif; other site 1310115007983 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 1310115007984 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1310115007985 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1310115007986 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1310115007987 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310115007988 Enoylreductase; Region: PKS_ER; smart00829 1310115007989 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1310115007990 NAD(P) binding site [chemical binding]; other site 1310115007991 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1310115007992 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1310115007993 putative NADP binding site [chemical binding]; other site 1310115007994 active site 1310115007995 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1310115007996 Erythronolide synthase docking; Region: Docking; pfam08990 1310115007997 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1310115007998 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1310115007999 active site 1310115008000 acyl-CoA synthetase; Validated; Region: PRK06060 1310115008001 Benzoate CoA ligase (BCL) and similar adenylate forming enzymes; Region: BCL_like; cd05919 1310115008002 dimer interface [polypeptide binding]; other site 1310115008003 acyl-activating enzyme (AAE) consensus motif; other site 1310115008004 putative active site [active] 1310115008005 putative AMP binding site [chemical binding]; other site 1310115008006 putative CoA binding site [chemical binding]; other site 1310115008007 chemical substrate binding site [chemical binding]; other site 1310115008008 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1310115008009 4-hydroxybenzoate synthetase (chorismate lyase) [Coenzyme metabolism]; Region: UbiC; COG3161 1310115008010 acyl-CoA synthetase; Validated; Region: PRK05850 1310115008011 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1310115008012 acyl-activating enzyme (AAE) consensus motif; other site 1310115008013 active site 1310115008014 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1310115008015 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1310115008016 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310115008017 S-adenosylmethionine binding site [chemical binding]; other site 1310115008018 Uncharacterized conserved protein [Function unknown]; Region: COG3268 1310115008019 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1310115008020 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310115008021 S-adenosylmethionine binding site [chemical binding]; other site 1310115008022 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1310115008023 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1310115008024 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 1310115008025 metal-binding site 1310115008026 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310115008027 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1310115008028 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1310115008029 active site 1310115008030 TDP-binding site; other site 1310115008031 acceptor substrate-binding pocket; other site 1310115008032 Cephalosporin hydroxylase [Defense mechanisms]; Region: CmcI; COG3510 1310115008033 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1310115008034 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1310115008035 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1310115008036 active site 1310115008037 TDP-binding site; other site 1310115008038 acceptor substrate-binding pocket; other site 1310115008039 Predicted permease; Region: DUF318; pfam03773 1310115008040 formyltetrahydrofolate deformylase; Region: PurU; TIGR00655 1310115008041 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1310115008042 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1310115008043 putative active site [active] 1310115008044 putative substrate binding site [chemical binding]; other site 1310115008045 putative cosubstrate binding site; other site 1310115008046 catalytic site [active] 1310115008047 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1310115008048 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1310115008049 active site 1310115008050 (T/H)XGH motif; other site 1310115008051 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1310115008052 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310115008053 S-adenosylmethionine binding site [chemical binding]; other site 1310115008054 pyruvate carboxylase; Reviewed; Region: PRK12999 1310115008055 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1310115008056 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1310115008057 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1310115008058 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1310115008059 active site 1310115008060 catalytic residues [active] 1310115008061 metal binding site [ion binding]; metal-binding site 1310115008062 homodimer binding site [polypeptide binding]; other site 1310115008063 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1310115008064 carboxyltransferase (CT) interaction site; other site 1310115008065 biotinylation site [posttranslational modification]; other site 1310115008066 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 1310115008067 putative active site [active] 1310115008068 redox center [active] 1310115008069 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1310115008070 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 1310115008071 catalytic residues [active] 1310115008072 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1310115008073 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1310115008074 substrate binding pocket [chemical binding]; other site 1310115008075 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 1310115008076 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1310115008077 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1310115008078 active site 1310115008079 catalytic tetrad [active] 1310115008080 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1310115008081 RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200 1310115008082 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1310115008083 generic binding surface II; other site 1310115008084 ssDNA binding site; other site 1310115008085 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1310115008086 ATP binding site [chemical binding]; other site 1310115008087 putative Mg++ binding site [ion binding]; other site 1310115008088 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1310115008089 nucleotide binding region [chemical binding]; other site 1310115008090 ATP-binding site [chemical binding]; other site 1310115008091 DAK2 domain; Region: Dak2; cl03685 1310115008092 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 1310115008093 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1310115008094 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1310115008095 ligand binding site [chemical binding]; other site 1310115008096 active site 1310115008097 UGI interface [polypeptide binding]; other site 1310115008098 catalytic site [active] 1310115008099 thiamine monophosphate kinase; Provisional; Region: PRK05731 1310115008100 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1310115008101 ATP binding site [chemical binding]; other site 1310115008102 dimerization interface [polypeptide binding]; other site 1310115008103 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1310115008104 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1310115008105 Probable transposase; Region: OrfB_IS605; pfam01385 1310115008106 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1310115008107 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 1310115008108 catalytic residues [active] 1310115008109 catalytic nucleophile [active] 1310115008110 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 1310115008111 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1310115008112 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1310115008113 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1310115008114 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1310115008115 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1310115008116 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1310115008117 Predicted nucleotidyltransferase, CobY/MobA/RfbA family [General function prediction only]; Region: COG1920 1310115008118 polyphosphate kinase; Provisional; Region: PRK05443 1310115008119 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1310115008120 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1310115008121 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1310115008122 putative domain interface [polypeptide binding]; other site 1310115008123 putative active site [active] 1310115008124 catalytic site [active] 1310115008125 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1310115008126 putative domain interface [polypeptide binding]; other site 1310115008127 putative active site [active] 1310115008128 catalytic site [active] 1310115008129 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1310115008130 active site 1310115008131 Ap6A binding site [chemical binding]; other site 1310115008132 nudix motif; other site 1310115008133 metal binding site [ion binding]; metal-binding site 1310115008134 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1310115008135 catalytic core [active] 1310115008136 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1310115008137 IHF - DNA interface [nucleotide binding]; other site 1310115008138 IHF dimer interface [polypeptide binding]; other site 1310115008139 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1310115008140 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1310115008141 substrate binding site [chemical binding]; other site 1310115008142 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1310115008143 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1310115008144 substrate binding site [chemical binding]; other site 1310115008145 ligand binding site [chemical binding]; other site 1310115008146 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1310115008147 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1310115008148 Bacterial transcriptional regulator; Region: IclR; pfam01614 1310115008149 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310115008150 S-adenosylmethionine binding site [chemical binding]; other site 1310115008151 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 1310115008152 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1310115008153 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1310115008154 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1310115008155 active site 1310115008156 HIGH motif; other site 1310115008157 nucleotide binding site [chemical binding]; other site 1310115008158 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1310115008159 active site 1310115008160 KMSKS motif; other site 1310115008161 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1310115008162 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1310115008163 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1310115008164 potential frameshift: common BLAST hit: gi|449065079|ref|YP_007432162.1| integral membrane protein 1310115008165 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 1310115008166 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1310115008167 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1310115008168 ligand binding site [chemical binding]; other site 1310115008169 NAD binding site [chemical binding]; other site 1310115008170 dimerization interface [polypeptide binding]; other site 1310115008171 catalytic site [active] 1310115008172 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1310115008173 putative L-serine binding site [chemical binding]; other site 1310115008174 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1310115008175 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1310115008176 Protein of unknown function (DUF433); Region: DUF433; pfam04255 1310115008177 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1310115008178 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1310115008179 phosphorylation site [posttranslational modification] 1310115008180 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 1310115008181 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 1310115008182 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 1310115008183 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1310115008184 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1310115008185 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1310115008186 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1310115008187 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1310115008188 putative valine binding site [chemical binding]; other site 1310115008189 dimer interface [polypeptide binding]; other site 1310115008190 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1310115008191 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 1310115008192 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1310115008193 PYR/PP interface [polypeptide binding]; other site 1310115008194 dimer interface [polypeptide binding]; other site 1310115008195 TPP binding site [chemical binding]; other site 1310115008196 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1310115008197 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1310115008198 TPP-binding site [chemical binding]; other site 1310115008199 dimer interface [polypeptide binding]; other site 1310115008200 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1310115008201 Predicted membrane protein [Function unknown]; Region: COG2259 1310115008202 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 1310115008203 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1310115008204 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1310115008205 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1310115008206 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1310115008207 GatB domain; Region: GatB_Yqey; smart00845 1310115008208 6-phosphofructokinase; Provisional; Region: PRK03202 1310115008209 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1310115008210 active site 1310115008211 ADP/pyrophosphate binding site [chemical binding]; other site 1310115008212 dimerization interface [polypeptide binding]; other site 1310115008213 allosteric effector site; other site 1310115008214 fructose-1,6-bisphosphate binding site; other site 1310115008215 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1310115008216 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1310115008217 aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, C subunit; Region: gatC; TIGR00135 1310115008218 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 1310115008219 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1310115008220 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1310115008221 nucleotide binding pocket [chemical binding]; other site 1310115008222 K-X-D-G motif; other site 1310115008223 catalytic site [active] 1310115008224 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1310115008225 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1310115008226 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1310115008227 Dimer interface [polypeptide binding]; other site 1310115008228 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 1310115008229 PknH-like extracellular domain; Region: PknH_C; pfam14032 1310115008230 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1310115008231 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115008232 PPE family; Region: PPE; pfam00823 1310115008233 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1310115008234 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115008235 PPE family; Region: PPE; pfam00823 1310115008236 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1310115008237 MULE transposase domain; Region: MULE; pfam10551 1310115008238 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1310115008239 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1310115008240 Ligand Binding Site [chemical binding]; other site 1310115008241 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1310115008242 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1310115008243 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1310115008244 catalytic residue [active] 1310115008245 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1310115008246 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1310115008247 putative acyl-acceptor binding pocket; other site 1310115008248 Putative hemolysin [General function prediction only]; Region: COG3176 1310115008249 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1310115008250 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1310115008251 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1310115008252 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1310115008253 Ligand binding site [chemical binding]; other site 1310115008254 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1310115008255 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310115008256 S-adenosylmethionine binding site [chemical binding]; other site 1310115008257 Uncharacterized conserved protein [Function unknown]; Region: COG1543 1310115008258 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1310115008259 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 1310115008260 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1310115008261 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1310115008262 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 1310115008263 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 1310115008264 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1310115008265 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1310115008266 trimer interface [polypeptide binding]; other site 1310115008267 active site 1310115008268 substrate binding site [chemical binding]; other site 1310115008269 CoA binding site [chemical binding]; other site 1310115008270 FOG: WD40-like repeat [Function unknown]; Region: COG1520 1310115008271 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1310115008272 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1310115008273 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1310115008274 substrate binding site [chemical binding]; other site 1310115008275 oxyanion hole (OAH) forming residues; other site 1310115008276 trimer interface [polypeptide binding]; other site 1310115008277 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 1310115008278 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1310115008279 Walker A/P-loop; other site 1310115008280 ATP binding site [chemical binding]; other site 1310115008281 Q-loop/lid; other site 1310115008282 ABC transporter signature motif; other site 1310115008283 Walker B; other site 1310115008284 D-loop; other site 1310115008285 H-loop/switch region; other site 1310115008286 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 1310115008287 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 1310115008288 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1310115008289 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1310115008290 motif II; other site 1310115008291 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1310115008292 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1310115008293 D-pathway; other site 1310115008294 Putative ubiquinol binding site [chemical binding]; other site 1310115008295 Low-spin heme (heme b) binding site [chemical binding]; other site 1310115008296 Putative water exit pathway; other site 1310115008297 Binuclear center (heme o3/CuB) [ion binding]; other site 1310115008298 K-pathway; other site 1310115008299 Putative proton exit pathway; other site 1310115008300 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 1310115008301 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1310115008302 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1310115008303 siderophore binding site; other site 1310115008304 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1310115008305 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1310115008306 putative NAD(P) binding site [chemical binding]; other site 1310115008307 putative substrate binding site [chemical binding]; other site 1310115008308 catalytic Zn binding site [ion binding]; other site 1310115008309 structural Zn binding site [ion binding]; other site 1310115008310 dimer interface [polypeptide binding]; other site 1310115008311 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 1310115008312 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1310115008313 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1310115008314 dimer interface [polypeptide binding]; other site 1310115008315 putative radical transfer pathway; other site 1310115008316 diiron center [ion binding]; other site 1310115008317 tyrosyl radical; other site 1310115008318 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1310115008319 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1310115008320 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310115008321 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310115008322 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 1310115008323 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1310115008324 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1310115008325 active site 1310115008326 dimer interface [polypeptide binding]; other site 1310115008327 catalytic residues [active] 1310115008328 effector binding site; other site 1310115008329 R2 peptide binding site; other site 1310115008330 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1310115008331 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1310115008332 catalytic residues [active] 1310115008333 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1310115008334 Predicted flavoprotein [General function prediction only]; Region: COG0431 1310115008335 DNA polymerase IV; Validated; Region: PRK03352 1310115008336 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1310115008337 active site 1310115008338 DNA binding site [nucleotide binding] 1310115008339 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310115008340 active site 1310115008341 classical (c) SDRs; Region: SDR_c; cd05233 1310115008342 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310115008343 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310115008344 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1310115008345 Cytochrome P450; Region: p450; cl12078 1310115008346 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1310115008347 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1310115008348 DNA-binding site [nucleotide binding]; DNA binding site 1310115008349 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1310115008350 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1310115008351 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1310115008352 DNA-binding site [nucleotide binding]; DNA binding site 1310115008353 FCD domain; Region: FCD; pfam07729 1310115008354 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1310115008355 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1310115008356 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1310115008357 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1310115008358 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1310115008359 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1310115008360 active site 1310115008361 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 1310115008362 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 1310115008363 active site 1310115008364 DNA binding site [nucleotide binding] 1310115008365 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 1310115008366 DNA binding site [nucleotide binding] 1310115008367 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 1310115008368 Carbon starvation protein CstA; Region: CstA; pfam02554 1310115008369 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1310115008370 Predicted membrane protein [Function unknown]; Region: COG2259 1310115008371 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 1310115008372 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1310115008373 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310115008374 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1310115008375 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 1310115008376 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1310115008377 active site 1310115008378 substrate binding site [chemical binding]; other site 1310115008379 metal binding site [ion binding]; metal-binding site 1310115008380 camphor resistance protein CrcB; Provisional; Region: PRK14216 1310115008381 camphor resistance protein CrcB; Provisional; Region: PRK14228 1310115008382 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 1310115008383 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 1310115008384 Uncharacterized ACR, COG1993; Region: DUF190; pfam02641 1310115008385 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1310115008386 Uncharacterized conserved protein [Function unknown]; Region: COG3189 1310115008387 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1310115008388 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1310115008389 active site 1310115008390 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1310115008391 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1310115008392 putative hydrophobic ligand binding site [chemical binding]; other site 1310115008393 protein interface [polypeptide binding]; other site 1310115008394 gate; other site 1310115008395 potential frameshift: common BLAST hit: gi|397675003|ref|YP_006516538.1| hydrolase 1310115008396 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1310115008397 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1310115008398 active site 1310115008399 ATP binding site [chemical binding]; other site 1310115008400 substrate binding site [chemical binding]; other site 1310115008401 activation loop (A-loop); other site 1310115008402 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 1310115008403 AAA ATPase domain; Region: AAA_16; pfam13191 1310115008404 Nucleotidyl transferase of unknown function (DUF2204); Region: DUF2204; pfam09970 1310115008405 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1310115008406 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1310115008407 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1310115008408 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1310115008409 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1310115008410 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1310115008411 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1310115008412 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310115008413 NAD(P) binding site [chemical binding]; other site 1310115008414 active site 1310115008415 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1310115008416 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1310115008417 NAD binding site [chemical binding]; other site 1310115008418 catalytic Zn binding site [ion binding]; other site 1310115008419 substrate binding site [chemical binding]; other site 1310115008420 structural Zn binding site [ion binding]; other site 1310115008421 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1310115008422 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1310115008423 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1310115008424 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1310115008425 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 1310115008426 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1310115008427 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1310115008428 acyl-activating enzyme (AAE) consensus motif; other site 1310115008429 AMP binding site [chemical binding]; other site 1310115008430 active site 1310115008431 CoA binding site [chemical binding]; other site 1310115008432 SPFH domain / Band 7 family; Region: Band_7; pfam01145 1310115008433 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1310115008434 Patatin-like phospholipase; Region: Patatin; pfam01734 1310115008435 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 1310115008436 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 1310115008437 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1310115008438 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1310115008439 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1310115008440 active site 1310115008441 Predicted transcriptional regulators [Transcription]; Region: COG1733 1310115008442 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1310115008443 dimerization interface [polypeptide binding]; other site 1310115008444 putative DNA binding site [nucleotide binding]; other site 1310115008445 putative Zn2+ binding site [ion binding]; other site 1310115008446 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 1310115008447 PE family; Region: PE; pfam00934 1310115008448 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1310115008449 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1310115008450 De-etiolated protein 1 Det1; Region: Det1; pfam09737 1310115008451 PemK-like protein; Region: PemK; pfam02452 1310115008452 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1310115008453 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1310115008454 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1310115008455 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1310115008456 SmpB-tmRNA interface; other site 1310115008457 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1310115008458 FtsX-like permease family; Region: FtsX; pfam02687 1310115008459 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1310115008460 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1310115008461 Walker A/P-loop; other site 1310115008462 ATP binding site [chemical binding]; other site 1310115008463 Q-loop/lid; other site 1310115008464 ABC transporter signature motif; other site 1310115008465 Walker B; other site 1310115008466 D-loop; other site 1310115008467 H-loop/switch region; other site 1310115008468 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1310115008469 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1310115008470 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1310115008471 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1310115008472 RF-1 domain; Region: RF-1; pfam00472 1310115008473 ferredoxin-NADP+ reductase; Region: PLN02852 1310115008474 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1310115008475 FAD binding domain; Region: FAD_binding_4; pfam01565 1310115008476 Molybdenum cofactor biosynthesis enzyme [Coenzyme metabolism]; Region: MoaA; COG2896 1310115008477 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1310115008478 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 1310115008479 aromatic arch; other site 1310115008480 DCoH dimer interaction site [polypeptide binding]; other site 1310115008481 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1310115008482 DCoH tetramer interaction site [polypeptide binding]; other site 1310115008483 substrate binding site [chemical binding]; other site 1310115008484 molybdenum cofactor biosynthesis protein MoaC; Provisional; Region: moaC; PRK09364 1310115008485 trimer interface [polypeptide binding]; other site 1310115008486 dimer interface [polypeptide binding]; other site 1310115008487 putative active site [active] 1310115008488 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1310115008489 MoaE interaction surface [polypeptide binding]; other site 1310115008490 MoeB interaction surface [polypeptide binding]; other site 1310115008491 thiocarboxylated glycine; other site 1310115008492 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1310115008493 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1310115008494 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1310115008495 nucleoside/Zn binding site; other site 1310115008496 dimer interface [polypeptide binding]; other site 1310115008497 catalytic motif [active] 1310115008498 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1310115008499 MULE transposase domain; Region: MULE; pfam10551 1310115008500 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 1310115008501 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1310115008502 ATP binding site [chemical binding]; other site 1310115008503 substrate interface [chemical binding]; other site 1310115008504 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1310115008505 active site residue [active] 1310115008506 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1310115008507 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1310115008508 active site residue [active] 1310115008509 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1310115008510 active site residue [active] 1310115008511 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 1310115008512 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1310115008513 MoaE homodimer interface [polypeptide binding]; other site 1310115008514 MoaD interaction [polypeptide binding]; other site 1310115008515 active site residues [active] 1310115008516 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310115008517 S-adenosylmethionine binding site [chemical binding]; other site 1310115008518 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1310115008519 Cytochrome P450; Region: p450; cl12078 1310115008520 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 1310115008521 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 1310115008522 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1310115008523 DNA binding site [nucleotide binding] 1310115008524 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115008525 PPE family; Region: PPE; pfam00823 1310115008526 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1310115008527 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1310115008528 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1310115008529 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1310115008530 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1310115008531 dimer interface [polypeptide binding]; other site 1310115008532 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1310115008533 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1310115008534 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1310115008535 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1310115008536 Histidine kinase; Region: HisKA_3; pfam07730 1310115008537 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1310115008538 ATP binding site [chemical binding]; other site 1310115008539 Mg2+ binding site [ion binding]; other site 1310115008540 G-X-G motif; other site 1310115008541 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1310115008542 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1310115008543 active site 1310115008544 phosphorylation site [posttranslational modification] 1310115008545 intermolecular recognition site; other site 1310115008546 dimerization interface [polypeptide binding]; other site 1310115008547 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1310115008548 DNA binding residues [nucleotide binding] 1310115008549 dimerization interface [polypeptide binding]; other site 1310115008550 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1310115008551 Ligand Binding Site [chemical binding]; other site 1310115008552 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115008553 PPE family; Region: PPE; pfam00823 1310115008554 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115008555 PPE family; Region: PPE; pfam00823 1310115008556 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1310115008557 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1310115008558 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 1310115008559 active site 1310115008560 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 1310115008561 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1310115008562 FeS/SAM binding site; other site 1310115008563 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1310115008564 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1310115008565 active site 1310115008566 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1310115008567 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1310115008568 active site 1310115008569 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1310115008570 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 1310115008571 NAD(P) binding site [chemical binding]; other site 1310115008572 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1310115008573 active site 1310115008574 phosphorylation site [posttranslational modification] 1310115008575 intermolecular recognition site; other site 1310115008576 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115008577 PPE family; Region: PPE; pfam00823 1310115008578 NADH dehydrogenase subunit A; Validated; Region: PRK07928 1310115008579 NADH dehydrogenase subunit B; Validated; Region: PRK06411 1310115008580 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 1310115008581 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1310115008582 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 1310115008583 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1310115008584 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1310115008585 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1310115008586 putative dimer interface [polypeptide binding]; other site 1310115008587 [2Fe-2S] cluster binding site [ion binding]; other site 1310115008588 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 1310115008589 SLBB domain; Region: SLBB; pfam10531 1310115008590 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 1310115008591 NADH dehydrogenase subunit G; Validated; Region: PRK07860 1310115008592 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1310115008593 catalytic loop [active] 1310115008594 iron binding site [ion binding]; other site 1310115008595 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1310115008596 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 1310115008597 [4Fe-4S] binding site [ion binding]; other site 1310115008598 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 1310115008599 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1310115008600 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1310115008601 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1310115008602 4Fe-4S binding domain; Region: Fer4; pfam00037 1310115008603 4Fe-4S binding domain; Region: Fer4; pfam00037 1310115008604 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1310115008605 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1310115008606 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1310115008607 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1310115008608 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1310115008609 potential frameshift: common BLAST hit: gi|15842733|ref|NP_337770.1| NADH dehydrogenase subunit M 1310115008610 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1310115008611 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1310115008612 potential frameshift: common BLAST hit: gi|449065253|ref|YP_007432336.1| PPE family protein 1310115008613 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1310115008614 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310115008615 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1310115008616 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1310115008617 [2Fe-2S] cluster binding site [ion binding]; other site 1310115008618 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1310115008619 hydrophobic ligand binding site; other site 1310115008620 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1310115008621 Protein of unknown function DUF58; Region: DUF58; pfam01882 1310115008622 MoxR-like ATPases [General function prediction only]; Region: COG0714 1310115008623 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1310115008624 Walker A motif; other site 1310115008625 ATP binding site [chemical binding]; other site 1310115008626 Walker B motif; other site 1310115008627 arginine finger; other site 1310115008628 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1310115008629 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310115008630 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310115008631 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1310115008632 putative active site [active] 1310115008633 putative substrate binding site [chemical binding]; other site 1310115008634 ATP binding site [chemical binding]; other site 1310115008635 Phosphotransferase enzyme family; Region: APH; pfam01636 1310115008636 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1310115008637 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1310115008638 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1310115008639 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1310115008640 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1310115008641 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310115008642 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310115008643 short chain dehydrogenase; Validated; Region: PRK08264 1310115008644 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310115008645 NAD(P) binding site [chemical binding]; other site 1310115008646 active site 1310115008647 short chain dehydrogenase; Validated; Region: PRK08264 1310115008648 amidase; Provisional; Region: PRK06170 1310115008649 Amidase; Region: Amidase; pfam01425 1310115008650 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1310115008651 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1310115008652 TAP-like protein; Region: Abhydrolase_4; pfam08386 1310115008653 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1310115008654 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 1310115008655 AAA domain; Region: AAA_14; pfam13173 1310115008656 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1310115008657 putative active site [active] 1310115008658 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1310115008659 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4683 1310115008660 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1310115008661 non-specific DNA binding site [nucleotide binding]; other site 1310115008662 salt bridge; other site 1310115008663 sequence-specific DNA binding site [nucleotide binding]; other site 1310115008664 RES domain; Region: RES; pfam08808 1310115008665 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1310115008666 Helix-turn-helix domain; Region: HTH_38; pfam13936 1310115008667 Integrase core domain; Region: rve; pfam00665 1310115008668 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1310115008669 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1310115008670 hypothetical protein; Validated; Region: PRK00068 1310115008671 Uncharacterized conserved protein [Function unknown]; Region: COG1615 1310115008672 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 1310115008673 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1310115008674 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1310115008675 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1310115008676 Uncharacterized conserved protein [Function unknown]; Region: COG5282 1310115008677 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 1310115008678 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 1310115008679 ABC1 family; Region: ABC1; pfam03109 1310115008680 Phosphotransferase enzyme family; Region: APH; pfam01636 1310115008681 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1310115008682 active site 1310115008683 ATP binding site [chemical binding]; other site 1310115008684 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1310115008685 Part of AAA domain; Region: AAA_19; pfam13245 1310115008686 Family description; Region: UvrD_C_2; pfam13538 1310115008687 HRDC domain; Region: HRDC; pfam00570 1310115008688 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1310115008689 catalytic residues [active] 1310115008690 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 1310115008691 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1310115008692 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1310115008693 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1310115008694 putative NADH binding site [chemical binding]; other site 1310115008695 putative active site [active] 1310115008696 nudix motif; other site 1310115008697 putative metal binding site [ion binding]; other site 1310115008698 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1310115008699 Part of AAA domain; Region: AAA_19; pfam13245 1310115008700 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 1310115008701 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1310115008702 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1310115008703 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 1310115008704 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1310115008705 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1310115008706 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1310115008707 active site 1310115008708 DNA binding site [nucleotide binding] 1310115008709 TIGR02569 family protein; Region: TIGR02569_actnb 1310115008710 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 1310115008711 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1310115008712 ATP binding site [chemical binding]; other site 1310115008713 substrate interface [chemical binding]; other site 1310115008714 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1310115008715 active site residue [active] 1310115008716 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 1310115008717 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310115008718 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310115008719 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 1310115008720 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like; Region: MiaE_2; pfam13794 1310115008721 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1310115008722 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1310115008723 ATP binding site [chemical binding]; other site 1310115008724 putative Mg++ binding site [ion binding]; other site 1310115008725 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1310115008726 nucleotide binding region [chemical binding]; other site 1310115008727 ATP-binding site [chemical binding]; other site 1310115008728 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1310115008729 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1310115008730 P-loop; other site 1310115008731 Magnesium ion binding site [ion binding]; other site 1310115008732 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1310115008733 Magnesium ion binding site [ion binding]; other site 1310115008734 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1310115008735 catalytic core [active] 1310115008736 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 1310115008737 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1310115008738 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1310115008739 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1310115008740 Transcription factor WhiB; Region: Whib; pfam02467 1310115008741 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 1310115008742 PAS domain S-box; Region: sensory_box; TIGR00229 1310115008743 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1310115008744 Histidine kinase; Region: HisKA_2; pfam07568 1310115008745 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1310115008746 ATP binding site [chemical binding]; other site 1310115008747 Mg2+ binding site [ion binding]; other site 1310115008748 G-X-G motif; other site 1310115008749 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1310115008750 carboxyltransferase (CT) interaction site; other site 1310115008751 biotinylation site [posttranslational modification]; other site 1310115008752 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 1310115008753 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 1310115008754 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1310115008755 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1310115008756 DNA binding residues [nucleotide binding] 1310115008757 short chain dehydrogenase; Provisional; Region: PRK08278 1310115008758 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 1310115008759 NAD(P) binding site [chemical binding]; other site 1310115008760 homodimer interface [polypeptide binding]; other site 1310115008761 active site 1310115008762 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 1310115008763 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 1310115008764 putative deacylase active site [active] 1310115008765 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1310115008766 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1310115008767 Coenzyme A binding pocket [chemical binding]; other site 1310115008768 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 1310115008769 Phosphotransferase enzyme family; Region: APH; pfam01636 1310115008770 putative active site [active] 1310115008771 putative substrate binding site [chemical binding]; other site 1310115008772 ATP binding site [chemical binding]; other site 1310115008773 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 1310115008774 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1310115008775 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1310115008776 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1310115008777 hinge; other site 1310115008778 active site 1310115008779 Predicted GTPases [General function prediction only]; Region: COG1162 1310115008780 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1310115008781 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1310115008782 GTP/Mg2+ binding site [chemical binding]; other site 1310115008783 G4 box; other site 1310115008784 G5 box; other site 1310115008785 G1 box; other site 1310115008786 Switch I region; other site 1310115008787 G2 box; other site 1310115008788 G3 box; other site 1310115008789 Switch II region; other site 1310115008790 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1310115008791 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1310115008792 putative di-iron ligands [ion binding]; other site 1310115008793 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 1310115008794 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1310115008795 FAD binding pocket [chemical binding]; other site 1310115008796 FAD binding motif [chemical binding]; other site 1310115008797 phosphate binding motif [ion binding]; other site 1310115008798 beta-alpha-beta structure motif; other site 1310115008799 NAD binding pocket [chemical binding]; other site 1310115008800 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1310115008801 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1310115008802 catalytic loop [active] 1310115008803 iron binding site [ion binding]; other site 1310115008804 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1310115008805 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1310115008806 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1310115008807 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1310115008808 TrkA-C domain; Region: TrkA_C; pfam02080 1310115008809 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1310115008810 potential frameshift: common BLAST hit: gi|471339290|ref|YP_007612003.1| transmembrane transport protein 1310115008811 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1310115008812 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1310115008813 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1310115008814 30S subunit binding site; other site 1310115008815 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1310115008816 active site 1310115008817 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 1310115008818 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1310115008819 lipoprotein LpqB; Provisional; Region: PRK13616 1310115008820 Sporulation and spore germination; Region: Germane; pfam10646 1310115008821 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1310115008822 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1310115008823 dimerization interface [polypeptide binding]; other site 1310115008824 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1310115008825 dimer interface [polypeptide binding]; other site 1310115008826 phosphorylation site [posttranslational modification] 1310115008827 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1310115008828 ATP binding site [chemical binding]; other site 1310115008829 Mg2+ binding site [ion binding]; other site 1310115008830 G-X-G motif; other site 1310115008831 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1310115008832 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1310115008833 active site 1310115008834 phosphorylation site [posttranslational modification] 1310115008835 intermolecular recognition site; other site 1310115008836 dimerization interface [polypeptide binding]; other site 1310115008837 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1310115008838 DNA binding site [nucleotide binding] 1310115008839 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 1310115008840 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1310115008841 TMP-binding site; other site 1310115008842 ATP-binding site [chemical binding]; other site 1310115008843 Adenosylhomocysteinase; Provisional; Region: PTZ00075 1310115008844 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1310115008845 homotetramer interface [polypeptide binding]; other site 1310115008846 ligand binding site [chemical binding]; other site 1310115008847 catalytic site [active] 1310115008848 NAD binding site [chemical binding]; other site 1310115008849 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310115008850 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1310115008851 Rubredoxin [Energy production and conversion]; Region: COG1773 1310115008852 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1310115008853 iron binding site [ion binding]; other site 1310115008854 Rubredoxin [Energy production and conversion]; Region: COG1773 1310115008855 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1310115008856 iron binding site [ion binding]; other site 1310115008857 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 1310115008858 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1310115008859 Di-iron ligands [ion binding]; other site 1310115008860 amino acid transporter; Region: 2A0306; TIGR00909 1310115008861 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1310115008862 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1310115008863 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1310115008864 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1310115008865 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1310115008866 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1310115008867 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 1310115008868 active site 1310115008869 substrate binding site [chemical binding]; other site 1310115008870 metal binding site [ion binding]; metal-binding site 1310115008871 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 1310115008872 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 1310115008873 Transcription factor WhiB; Region: Whib; pfam02467 1310115008874 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 1310115008875 LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186 1310115008876 phosphate binding site [ion binding]; other site 1310115008877 dimer interface [polypeptide binding]; other site 1310115008878 substrate binding site [chemical binding]; other site 1310115008879 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 1310115008880 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 1310115008881 F420 biosynthesis protein FbiB, C-terminal domain; Region: F420_FbiB_CTERM; TIGR03553 1310115008882 FMN binding site [chemical binding]; other site 1310115008883 dimer interface [polypeptide binding]; other site 1310115008884 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1310115008885 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1310115008886 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1310115008887 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1310115008888 active site 1310115008889 Substrate binding site; other site 1310115008890 Mg++ binding site; other site 1310115008891 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1310115008892 potential frameshift: common BLAST hit: gi|471339319|ref|YP_007612032.1| dTDP-RHA:A-D-GlcNAc-diphosphoryl polyprenolA-3-L-rhamnosyl 1310115008893 dTDP-4-dehydrorhamnose reductase; Region: rmlD; TIGR01214 1310115008894 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1310115008895 NADP binding site [chemical binding]; other site 1310115008896 active site 1310115008897 putative substrate binding site [chemical binding]; other site 1310115008898 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1310115008899 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1310115008900 TIGR03089 family protein; Region: TIGR03089 1310115008901 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 1310115008902 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1310115008903 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1310115008904 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1310115008905 active site 1310115008906 motif I; other site 1310115008907 motif II; other site 1310115008908 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1310115008909 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1310115008910 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1310115008911 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1310115008912 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1310115008913 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: CynT; COG0288 1310115008914 active site clefts [active] 1310115008915 zinc binding site [ion binding]; other site 1310115008916 dimer interface [polypeptide binding]; other site 1310115008917 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1310115008918 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1310115008919 FAD binding site [chemical binding]; other site 1310115008920 homotetramer interface [polypeptide binding]; other site 1310115008921 substrate binding pocket [chemical binding]; other site 1310115008922 catalytic base [active] 1310115008923 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1310115008924 Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) [Nucleotide transport and metabolism]; Region: PurK; COG0026 1310115008925 ATP-grasp domain; Region: ATP-grasp; pfam02222 1310115008926 Predicted membrane protein [Function unknown]; Region: COG2246 1310115008927 GtrA-like protein; Region: GtrA; pfam04138 1310115008928 Bacterial PH domain; Region: DUF304; pfam03703 1310115008929 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1310115008930 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1310115008931 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1310115008932 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1310115008933 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1310115008934 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1310115008935 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 1310115008936 Maf-like protein; Region: Maf; pfam02545 1310115008937 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1310115008938 active site 1310115008939 dimer interface [polypeptide binding]; other site 1310115008940 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1310115008941 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1310115008942 active site residue [active] 1310115008943 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1310115008944 active site residue [active] 1310115008945 Fe-S metabolism associated domain; Region: SufE; pfam02657 1310115008946 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1310115008947 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1310115008948 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1310115008949 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1310115008950 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1310115008951 carboxyltransferase (CT) interaction site; other site 1310115008952 biotinylation site [posttranslational modification]; other site 1310115008953 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 1310115008954 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1310115008955 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1310115008956 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1310115008957 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1310115008958 L-lysine aminotransferase; Provisional; Region: PRK08297 1310115008959 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1310115008960 inhibitor-cofactor binding pocket; inhibition site 1310115008961 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310115008962 catalytic residue [active] 1310115008963 putative DNA binding site [nucleotide binding]; other site 1310115008964 dimerization interface [polypeptide binding]; other site 1310115008965 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1310115008966 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1310115008967 putative Zn2+ binding site [ion binding]; other site 1310115008968 AsnC family; Region: AsnC_trans_reg; pfam01037 1310115008969 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 1310115008970 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 1310115008971 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1310115008972 tetrameric interface [polypeptide binding]; other site 1310115008973 NAD binding site [chemical binding]; other site 1310115008974 catalytic residues [active] 1310115008975 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 1310115008976 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310115008977 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310115008978 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1310115008979 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 1310115008980 ATP binding site [chemical binding]; other site 1310115008981 putative Mg++ binding site [ion binding]; other site 1310115008982 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1310115008983 nucleotide binding region [chemical binding]; other site 1310115008984 ATP-binding site [chemical binding]; other site 1310115008985 DEAD/H associated; Region: DEAD_assoc; pfam08494 1310115008986 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1310115008987 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 1310115008988 putative DNA binding site [nucleotide binding]; other site 1310115008989 catalytic residue [active] 1310115008990 putative H2TH interface [polypeptide binding]; other site 1310115008991 putative catalytic residues [active] 1310115008992 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1310115008993 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1310115008994 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1310115008995 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1310115008996 Sulfatase; Region: Sulfatase; pfam00884 1310115008997 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 1310115008998 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1310115008999 probable active site [active] 1310115009000 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1310115009001 PhoU domain; Region: PhoU; pfam01895 1310115009002 PhoU domain; Region: PhoU; pfam01895 1310115009003 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1310115009004 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 1310115009005 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1310115009006 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1310115009007 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1310115009008 putative active site pocket [active] 1310115009009 dimerization interface [polypeptide binding]; other site 1310115009010 putative catalytic residue [active] 1310115009011 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1310115009012 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 1310115009013 metal binding site [ion binding]; metal-binding site 1310115009014 putative dimer interface [polypeptide binding]; other site 1310115009015 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 1310115009016 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1310115009017 metal binding site [ion binding]; metal-binding site 1310115009018 potential frameshift: common BLAST hit: gi|471339361|ref|YP_007612074.1| purine nucleoside phosphorylase 1310115009019 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1310115009020 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1310115009021 active site 1310115009022 substrate binding site [chemical binding]; other site 1310115009023 metal binding site [ion binding]; metal-binding site 1310115009024 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1310115009025 active site 1310115009026 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1310115009027 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1310115009028 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1310115009029 adenosine deaminase; Provisional; Region: PRK09358 1310115009030 active site 1310115009031 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 1310115009032 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1310115009033 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1310115009034 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1310115009035 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1310115009036 active site 1310115009037 catalytic motif [active] 1310115009038 Zn binding site [ion binding]; other site 1310115009039 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 1310115009040 putative Iron-sulfur protein interface [polypeptide binding]; other site 1310115009041 putative proximal heme binding site [chemical binding]; other site 1310115009042 putative SdhD-like interface [polypeptide binding]; other site 1310115009043 putative distal heme binding site [chemical binding]; other site 1310115009044 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 1310115009045 putative Iron-sulfur protein interface [polypeptide binding]; other site 1310115009046 putative proximal heme binding site [chemical binding]; other site 1310115009047 putative SdhC-like subunit interface [polypeptide binding]; other site 1310115009048 putative distal heme binding site [chemical binding]; other site 1310115009049 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 1310115009050 L-aspartate oxidase; Provisional; Region: PRK06175 1310115009051 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1310115009052 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1310115009053 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1310115009054 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1310115009055 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1310115009056 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310115009057 S-adenosylmethionine binding site [chemical binding]; other site 1310115009058 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1310115009059 MoaE interaction surface [polypeptide binding]; other site 1310115009060 MoeB interaction surface [polypeptide binding]; other site 1310115009061 thiocarboxylated glycine; other site 1310115009062 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1310115009063 MoaE homodimer interface [polypeptide binding]; other site 1310115009064 MoaD interaction [polypeptide binding]; other site 1310115009065 active site residues [active] 1310115009066 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1310115009067 trimer interface [polypeptide binding]; other site 1310115009068 dimer interface [polypeptide binding]; other site 1310115009069 putative active site [active] 1310115009070 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942 1310115009071 substrate binding site [chemical binding]; other site 1310115009072 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1310115009073 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1310115009074 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1310115009075 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1310115009076 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 1310115009077 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1310115009078 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1310115009079 DNA binding residues [nucleotide binding] 1310115009080 SnoaL-like domain; Region: SnoaL_2; pfam12680 1310115009081 hypothetical protein; Provisional; Region: PRK06541 1310115009082 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1310115009083 inhibitor-cofactor binding pocket; inhibition site 1310115009084 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310115009085 catalytic residue [active] 1310115009086 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1310115009087 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1310115009088 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1310115009089 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310115009090 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1310115009091 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1310115009092 active site 1310115009093 dimer interface [polypeptide binding]; other site 1310115009094 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1310115009095 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 1310115009096 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1310115009097 DNA binding residues [nucleotide binding] 1310115009098 dimer interface [polypeptide binding]; other site 1310115009099 metal binding site [ion binding]; metal-binding site 1310115009100 inner membrane protein YhjD; Region: TIGR00766 1310115009101 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1310115009102 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1310115009103 active site 1310115009104 HIGH motif; other site 1310115009105 dimer interface [polypeptide binding]; other site 1310115009106 KMSKS motif; other site 1310115009107 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1310115009108 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 1310115009109 isocitrate dehydrogenase; Validated; Region: PRK08299 1310115009110 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 1310115009111 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1310115009112 homodimer interface [polypeptide binding]; other site 1310115009113 substrate-cofactor binding pocket; other site 1310115009114 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310115009115 catalytic residue [active] 1310115009116 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 1310115009117 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 1310115009118 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1310115009119 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310115009120 S-adenosylmethionine binding site [chemical binding]; other site 1310115009121 PPE family; Region: PPE; pfam00823 1310115009122 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115009123 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115009124 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310115009125 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310115009126 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310115009127 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115009128 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310115009129 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310115009130 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115009131 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310115009132 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310115009133 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310115009134 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115009135 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310115009136 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310115009137 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310115009138 PE family; Region: PE; pfam00934 1310115009139 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 1310115009140 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115009141 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310115009142 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310115009143 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115009144 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310115009145 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310115009146 PPE family; Region: PPE; pfam00823 1310115009147 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310115009148 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310115009149 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115009150 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310115009151 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310115009152 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1310115009153 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1310115009154 potential frameshift: common BLAST hit: gi|392433836|ref|YP_006474880.1| PPE family protein 1310115009155 Berberine and berberine like; Region: BBE; pfam08031 1310115009156 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1310115009157 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1310115009158 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 1310115009159 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 1310115009160 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1310115009161 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1310115009162 homodimer interface [polypeptide binding]; other site 1310115009163 NADP binding site [chemical binding]; other site 1310115009164 substrate binding site [chemical binding]; other site 1310115009165 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 1310115009166 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 1310115009167 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1310115009168 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 1310115009169 active site 1310115009170 FMN binding site [chemical binding]; other site 1310115009171 substrate binding site [chemical binding]; other site 1310115009172 putative catalytic residue [active] 1310115009173 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1310115009174 phosphate binding site [ion binding]; other site 1310115009175 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1310115009176 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1310115009177 phosphopeptide binding site; other site 1310115009178 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1310115009179 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1310115009180 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1310115009181 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1310115009182 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1310115009183 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 1310115009184 G1 box; other site 1310115009185 GTP/Mg2+ binding site [chemical binding]; other site 1310115009186 G2 box; other site 1310115009187 Switch I region; other site 1310115009188 G3 box; other site 1310115009189 Switch II region; other site 1310115009190 G4 box; other site 1310115009191 G5 box; other site 1310115009192 Protein of unknown function (DUF742); Region: DUF742; pfam05331 1310115009193 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 1310115009194 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1310115009195 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1310115009196 ATP binding site [chemical binding]; other site 1310115009197 Mg2+ binding site [ion binding]; other site 1310115009198 G-X-G motif; other site 1310115009199 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1310115009200 PE family; Region: PE; pfam00934 1310115009201 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 1310115009202 FMN binding site [chemical binding]; other site 1310115009203 dimer interface [polypeptide binding]; other site 1310115009204 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1310115009205 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 1310115009206 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1310115009207 active site 1310115009208 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1310115009209 generic binding surface II; other site 1310115009210 generic binding surface I; other site 1310115009211 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1310115009212 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1310115009213 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1310115009214 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 1310115009215 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1310115009216 active site 1310115009217 motif I; other site 1310115009218 motif II; other site 1310115009219 PE family; Region: PE; pfam00934 1310115009220 potential frameshift: common BLAST hit: gi|449065488|ref|YP_007432571.1| enoyl-CoA hydratase 1310115009221 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1310115009222 Amidase; Region: Amidase; pfam01425 1310115009223 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1310115009224 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1310115009225 motif II; other site 1310115009226 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 1310115009227 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 1310115009228 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1310115009229 TPP-binding site [chemical binding]; other site 1310115009230 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1310115009231 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1310115009232 PYR/PP interface [polypeptide binding]; other site 1310115009233 dimer interface [polypeptide binding]; other site 1310115009234 TPP binding site [chemical binding]; other site 1310115009235 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1310115009236 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1310115009237 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1310115009238 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1310115009239 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1310115009240 substrate binding pocket [chemical binding]; other site 1310115009241 chain length determination region; other site 1310115009242 substrate-Mg2+ binding site; other site 1310115009243 catalytic residues [active] 1310115009244 aspartate-rich region 1; other site 1310115009245 active site lid residues [active] 1310115009246 aspartate-rich region 2; other site 1310115009247 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 1310115009248 putative active site [active] 1310115009249 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1310115009250 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1310115009251 Transposase domain (DUF772); Region: DUF772; pfam05598 1310115009252 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1310115009253 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1310115009254 PE family; Region: PE; pfam00934 1310115009255 enoyl-CoA hydratase; Region: PLN02864 1310115009256 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1310115009257 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 1310115009258 dimer interaction site [polypeptide binding]; other site 1310115009259 substrate-binding tunnel; other site 1310115009260 active site 1310115009261 catalytic site [active] 1310115009262 substrate binding site [chemical binding]; other site 1310115009263 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1310115009264 short chain dehydrogenase; Provisional; Region: PRK07201 1310115009265 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 1310115009266 putative NAD(P) binding site [chemical binding]; other site 1310115009267 active site 1310115009268 putative substrate binding site [chemical binding]; other site 1310115009269 classical (c) SDRs; Region: SDR_c; cd05233 1310115009270 NAD(P) binding site [chemical binding]; other site 1310115009271 active site 1310115009272 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1310115009273 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310115009274 S-adenosylmethionine binding site [chemical binding]; other site 1310115009275 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 1310115009276 active site 1310115009277 DNA Polymerase Y-family; Region: PolY_like; cd03468 1310115009278 DNA binding site [nucleotide binding] 1310115009279 GMP synthase; Reviewed; Region: guaA; PRK00074 1310115009280 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1310115009281 AMP/PPi binding site [chemical binding]; other site 1310115009282 candidate oxyanion hole; other site 1310115009283 catalytic triad [active] 1310115009284 potential glutamine specificity residues [chemical binding]; other site 1310115009285 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1310115009286 ATP Binding subdomain [chemical binding]; other site 1310115009287 Ligand Binding sites [chemical binding]; other site 1310115009288 Dimerization subdomain; other site 1310115009289 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1310115009290 active site lid residues [active] 1310115009291 substrate binding pocket [chemical binding]; other site 1310115009292 catalytic residues [active] 1310115009293 substrate-Mg2+ binding site; other site 1310115009294 aspartate-rich region 1; other site 1310115009295 aspartate-rich region 2; other site 1310115009296 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1310115009297 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1310115009298 substrate binding pocket [chemical binding]; other site 1310115009299 chain length determination region; other site 1310115009300 substrate-Mg2+ binding site; other site 1310115009301 catalytic residues [active] 1310115009302 aspartate-rich region 1; other site 1310115009303 active site lid residues [active] 1310115009304 aspartate-rich region 2; other site 1310115009305 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1310115009306 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1310115009307 potential frameshift: common BLAST hit: gi|449065513|ref|YP_007432596.1| hydrolase 1310115009308 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1310115009309 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1310115009310 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1310115009311 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1310115009312 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1310115009313 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1310115009314 inhibitor-cofactor binding pocket; inhibition site 1310115009315 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310115009316 catalytic residue [active] 1310115009317 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 1310115009318 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1310115009319 hypothetical protein; Provisional; Region: PRK07579 1310115009320 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 1310115009321 active site 1310115009322 cosubstrate binding site; other site 1310115009323 substrate binding site [chemical binding]; other site 1310115009324 catalytic site [active] 1310115009325 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310115009326 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310115009327 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1310115009328 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1310115009329 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1310115009330 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 1310115009331 putative active site [active] 1310115009332 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1310115009333 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1310115009334 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1310115009335 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 1310115009336 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1310115009337 phosphate binding site [ion binding]; other site 1310115009338 potential frameshift: common BLAST hit: gi|449065524|ref|YP_007432607.1| inosine 5'-monophosphate dehydrogenase 1310115009339 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 1310115009340 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1310115009341 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1310115009342 DNA binding residues [nucleotide binding] 1310115009343 Transcription factor WhiB; Region: Whib; pfam02467 1310115009344 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1310115009345 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1310115009346 ring oligomerisation interface [polypeptide binding]; other site 1310115009347 ATP/Mg binding site [chemical binding]; other site 1310115009348 stacking interactions; other site 1310115009349 hinge regions; other site 1310115009350 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1310115009351 oligomerisation interface [polypeptide binding]; other site 1310115009352 mobile loop; other site 1310115009353 roof hairpin; other site 1310115009354 UGMP family protein; Validated; Region: PRK09604 1310115009355 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1310115009356 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1310115009357 Coenzyme A binding pocket [chemical binding]; other site 1310115009358 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 1310115009359 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 1310115009360 alanine racemase; Reviewed; Region: alr; PRK00053 1310115009361 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1310115009362 active site 1310115009363 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1310115009364 dimer interface [polypeptide binding]; other site 1310115009365 substrate binding site [chemical binding]; other site 1310115009366 catalytic residues [active] 1310115009367 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115009368 PPE family; Region: PPE; pfam00823 1310115009369 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115009370 PPE family; Region: PPE; pfam00823 1310115009371 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1310115009372 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1310115009373 Walker A motif; other site 1310115009374 ATP binding site [chemical binding]; other site 1310115009375 Walker B motif; other site 1310115009376 arginine finger; other site 1310115009377 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115009378 PPE family; Region: PPE; pfam00823 1310115009379 Integrase core domain; Region: rve; pfam00665 1310115009380 Integrase core domain; Region: rve_3; pfam13683 1310115009381 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1310115009382 MULE transposase domain; Region: MULE; pfam10551 1310115009383 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 1310115009384 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310115009385 catalytic residue [active] 1310115009386 Uncharacterized conserved protein [Function unknown]; Region: COG0062 1310115009387 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1310115009388 putative substrate binding site [chemical binding]; other site 1310115009389 putative ATP binding site [chemical binding]; other site 1310115009390 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1310115009391 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1310115009392 glutaminase active site [active] 1310115009393 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1310115009394 dimer interface [polypeptide binding]; other site 1310115009395 active site 1310115009396 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1310115009397 dimer interface [polypeptide binding]; other site 1310115009398 active site 1310115009399 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 1310115009400 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 1310115009401 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1310115009402 active site 1310115009403 substrate binding site [chemical binding]; other site 1310115009404 metal binding site [ion binding]; metal-binding site 1310115009405 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1310115009406 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1310115009407 23S rRNA interface [nucleotide binding]; other site 1310115009408 L3 interface [polypeptide binding]; other site 1310115009409 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1310115009410 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1310115009411 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 1310115009412 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1310115009413 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1310115009414 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1310115009415 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1310115009416 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1310115009417 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1310115009418 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1310115009419 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1310115009420 active site 1310115009421 catalytic residues [active] 1310115009422 Protein of unknown function (DUF690); Region: DUF690; pfam05108 1310115009423 Cutinase; Region: Cutinase; pfam01083 1310115009424 Cutinase; Region: Cutinase; pfam01083 1310115009425 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1310115009426 Pseudouridylate synthase [Translation, ribosomal structure and biogenesis]; Region: TruA; COG0101 1310115009427 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1310115009428 dimerization interface 3.5A [polypeptide binding]; other site 1310115009429 active site 1310115009430 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1310115009431 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1310115009432 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1310115009433 alphaNTD - beta interaction site [polypeptide binding]; other site 1310115009434 alphaNTD homodimer interface [polypeptide binding]; other site 1310115009435 alphaNTD - beta' interaction site [polypeptide binding]; other site 1310115009436 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1310115009437 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1310115009438 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1310115009439 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1310115009440 RNA binding surface [nucleotide binding]; other site 1310115009441 30S ribosomal protein S11; Validated; Region: PRK05309 1310115009442 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1310115009443 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1310115009444 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1310115009445 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1310115009446 rRNA binding site [nucleotide binding]; other site 1310115009447 predicted 30S ribosome binding site; other site 1310115009448 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1310115009449 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 1310115009450 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1310115009451 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1310115009452 NAD binding site [chemical binding]; other site 1310115009453 substrate binding site [chemical binding]; other site 1310115009454 homodimer interface [polypeptide binding]; other site 1310115009455 active site 1310115009456 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 1310115009457 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1310115009458 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1310115009459 active site 1310115009460 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1310115009461 extended (e) SDRs; Region: SDR_e; cd08946 1310115009462 NAD(P) binding site [chemical binding]; other site 1310115009463 active site 1310115009464 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 1310115009465 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 1310115009466 active site 1310115009467 catalytic residues [active] 1310115009468 metal binding site [ion binding]; metal-binding site 1310115009469 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1310115009470 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1310115009471 PYR/PP interface [polypeptide binding]; other site 1310115009472 dimer interface [polypeptide binding]; other site 1310115009473 TPP binding site [chemical binding]; other site 1310115009474 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1310115009475 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1310115009476 TPP-binding site [chemical binding]; other site 1310115009477 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1310115009478 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1310115009479 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1310115009480 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1310115009481 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310115009482 metabolite-proton symporter; Region: 2A0106; TIGR00883 1310115009483 putative substrate translocation pore; other site 1310115009484 PE family; Region: PE; pfam00934 1310115009485 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115009486 PPE family; Region: PPE; pfam00823 1310115009487 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1310115009488 patatin-related protein; Region: TIGR03607 1310115009489 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1310115009490 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1310115009491 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 1310115009492 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1310115009493 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 1310115009494 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 1310115009495 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1310115009496 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1310115009497 short chain dehydrogenase; Provisional; Region: PRK05875 1310115009498 classical (c) SDRs; Region: SDR_c; cd05233 1310115009499 NAD(P) binding site [chemical binding]; other site 1310115009500 active site 1310115009501 Predicted membrane protein [Function unknown]; Region: COG2259 1310115009502 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1310115009503 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1310115009504 Predicted transcriptional regulators [Transcription]; Region: COG1695 1310115009505 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1310115009506 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 1310115009507 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1310115009508 active site 1310115009509 homotetramer interface [polypeptide binding]; other site 1310115009510 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1310115009511 mce related protein; Region: MCE; pfam02470 1310115009512 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1310115009513 mce related protein; Region: MCE; pfam02470 1310115009514 mce related protein; Region: MCE; pfam02470 1310115009515 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1310115009516 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1310115009517 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1310115009518 mce related protein; Region: MCE; pfam02470 1310115009519 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1310115009520 mce related protein; Region: MCE; pfam02470 1310115009521 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1310115009522 mce related protein; Region: MCE; pfam02470 1310115009523 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1310115009524 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1310115009525 Permease; Region: Permease; pfam02405 1310115009526 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1310115009527 Permease; Region: Permease; pfam02405 1310115009528 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 1310115009529 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310115009530 NAD(P) binding site [chemical binding]; other site 1310115009531 active site 1310115009532 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1310115009533 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1310115009534 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1310115009535 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 1310115009536 FAD binding site [chemical binding]; other site 1310115009537 substrate binding site [chemical binding]; other site 1310115009538 catalytic base [active] 1310115009539 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1310115009540 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1310115009541 active site 1310115009542 acyl-CoA synthetase; Validated; Region: PRK07867 1310115009543 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 1310115009544 acyl-activating enzyme (AAE) consensus motif; other site 1310115009545 putative AMP binding site [chemical binding]; other site 1310115009546 putative active site [active] 1310115009547 putative CoA binding site [chemical binding]; other site 1310115009548 PE family; Region: PE; pfam00934 1310115009549 PE family; Region: PE; pfam00934 1310115009550 hypothetical protein; Validated; Region: PRK07586 1310115009551 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1310115009552 PYR/PP interface [polypeptide binding]; other site 1310115009553 dimer interface [polypeptide binding]; other site 1310115009554 TPP binding site [chemical binding]; other site 1310115009555 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 1310115009556 TPP-binding site [chemical binding]; other site 1310115009557 dimer interface [polypeptide binding]; other site 1310115009558 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1310115009559 PE family; Region: PE; pfam00934 1310115009560 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1310115009561 CoA binding site [chemical binding]; other site 1310115009562 PE family; Region: PE; pfam00934 1310115009563 acyl-CoA synthetase; Validated; Region: PRK07798 1310115009564 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1310115009565 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 1310115009566 acyl-activating enzyme (AAE) consensus motif; other site 1310115009567 acyl-activating enzyme (AAE) consensus motif; other site 1310115009568 putative AMP binding site [chemical binding]; other site 1310115009569 putative active site [active] 1310115009570 putative CoA binding site [chemical binding]; other site 1310115009571 enoyl-CoA hydratase; Provisional; Region: PRK07799 1310115009572 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1310115009573 substrate binding site [chemical binding]; other site 1310115009574 oxyanion hole (OAH) forming residues; other site 1310115009575 trimer interface [polypeptide binding]; other site 1310115009576 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1310115009577 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1310115009578 Cytochrome P450; Region: p450; cl12078 1310115009579 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 1310115009580 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1310115009581 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 1310115009582 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1310115009583 DUF35 OB-fold domain; Region: DUF35; pfam01796 1310115009584 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1310115009585 DUF35 OB-fold domain; Region: DUF35; pfam01796 1310115009586 lipid-transfer protein; Provisional; Region: PRK07937 1310115009587 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1310115009588 active site 1310115009589 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 1310115009590 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1310115009591 active site 1310115009592 NHL repeat; Region: NHL; pfam01436 1310115009593 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1310115009594 NHL repeat; Region: NHL; pfam01436 1310115009595 NHL repeat; Region: NHL; pfam01436 1310115009596 NHL repeat; Region: NHL; pfam01436 1310115009597 NHL repeat; Region: NHL; pfam01436 1310115009598 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1310115009599 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1310115009600 trimer interface [polypeptide binding]; other site 1310115009601 putative metal binding site [ion binding]; other site 1310115009602 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1310115009603 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 1310115009604 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 1310115009605 short chain dehydrogenase; Provisional; Region: PRK07890 1310115009606 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310115009607 NAD(P) binding site [chemical binding]; other site 1310115009608 active site 1310115009609 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115009610 PPE family; Region: PPE; pfam00823 1310115009611 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1310115009612 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115009613 PPE family; Region: PPE; pfam00823 1310115009614 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310115009615 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310115009616 DmpG-like communication domain; Region: DmpG_comm; pfam07836 1310115009617 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 1310115009618 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 1310115009619 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 1310115009620 active site 1310115009621 catalytic residues [active] 1310115009622 metal binding site [ion binding]; metal-binding site 1310115009623 acetaldehyde dehydrogenase; Validated; Region: PRK08300 1310115009624 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1310115009625 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 1310115009626 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971 1310115009627 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 1310115009628 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1310115009629 potential frameshift: common BLAST hit: gi|471339619|ref|YP_007612332.1| dehydrogenase 1310115009630 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115009631 PPE family; Region: PPE; pfam00823 1310115009632 PE-PPE domain; Region: PE-PPE; pfam08237 1310115009633 lipid-transfer protein; Provisional; Region: PRK07855 1310115009634 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1310115009635 active site 1310115009636 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 1310115009637 putative active site [active] 1310115009638 putative catalytic site [active] 1310115009639 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1310115009640 active site 1310115009641 catalytic site [active] 1310115009642 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1310115009643 DUF35 OB-fold domain; Region: DUF35; pfam01796 1310115009644 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1310115009645 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1310115009646 active site 1310115009647 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1310115009648 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1310115009649 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1310115009650 active site 1310115009651 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1310115009652 Cytochrome P450; Region: p450; cl12078 1310115009653 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 1310115009654 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1310115009655 dimer interface [polypeptide binding]; other site 1310115009656 active site 1310115009657 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1310115009658 short chain dehydrogenase; Provisional; Region: PRK07791 1310115009659 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 1310115009660 homodimer interface [polypeptide binding]; other site 1310115009661 NAD binding site [chemical binding]; other site 1310115009662 active site 1310115009663 short chain dehydrogenase; Provisional; Region: PRK07856 1310115009664 classical (c) SDRs; Region: SDR_c; cd05233 1310115009665 NAD(P) binding site [chemical binding]; other site 1310115009666 active site 1310115009667 enoyl-CoA hydratase; Provisional; Region: PRK06495 1310115009668 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1310115009669 substrate binding site [chemical binding]; other site 1310115009670 oxyanion hole (OAH) forming residues; other site 1310115009671 trimer interface [polypeptide binding]; other site 1310115009672 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1310115009673 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057 1310115009674 potential frameshift: common BLAST hit: gi|471339634|ref|YP_007612347.1| oxidoreductase 1310115009675 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1310115009676 Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514 1310115009677 putative di-iron ligands [ion binding]; other site 1310115009678 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1310115009679 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1310115009680 FAD binding pocket [chemical binding]; other site 1310115009681 FAD binding motif [chemical binding]; other site 1310115009682 phosphate binding motif [ion binding]; other site 1310115009683 beta-alpha-beta structure motif; other site 1310115009684 NAD(p) ribose binding residues [chemical binding]; other site 1310115009685 NAD binding pocket [chemical binding]; other site 1310115009686 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1310115009687 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1310115009688 catalytic loop [active] 1310115009689 iron binding site [ion binding]; other site 1310115009690 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1310115009691 putative active site [active] 1310115009692 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 1310115009693 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1310115009694 dimer interface [polypeptide binding]; other site 1310115009695 active site 1310115009696 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310115009697 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310115009698 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115009699 PPE family; Region: PPE; pfam00823 1310115009700 short chain dehydrogenase; Provisional; Region: PRK07831 1310115009701 classical (c) SDRs; Region: SDR_c; cd05233 1310115009702 NAD(P) binding site [chemical binding]; other site 1310115009703 active site 1310115009704 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1310115009705 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1310115009706 active site 1310115009707 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1310115009708 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1310115009709 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1310115009710 acyl-activating enzyme (AAE) consensus motif; other site 1310115009711 putative AMP binding site [chemical binding]; other site 1310115009712 putative active site [active] 1310115009713 putative CoA binding site [chemical binding]; other site 1310115009714 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1310115009715 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1310115009716 active site 1310115009717 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1310115009718 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1310115009719 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1310115009720 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1310115009721 active site 1310115009722 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1310115009723 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1310115009724 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1310115009725 active site 1310115009726 aspartate aminotransferase; Provisional; Region: PRK05764 1310115009727 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1310115009728 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310115009729 homodimer interface [polypeptide binding]; other site 1310115009730 catalytic residue [active] 1310115009731 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 1310115009732 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1310115009733 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 1310115009734 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 1310115009735 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 1310115009736 active site 1310115009737 Fe binding site [ion binding]; other site 1310115009738 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 1310115009739 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1310115009740 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 1310115009741 Flavin binding site [chemical binding]; other site 1310115009742 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1310115009743 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1310115009744 FAD binding pocket [chemical binding]; other site 1310115009745 FAD binding motif [chemical binding]; other site 1310115009746 phosphate binding motif [ion binding]; other site 1310115009747 beta-alpha-beta structure motif; other site 1310115009748 NAD(p) ribose binding residues [chemical binding]; other site 1310115009749 NAD binding pocket [chemical binding]; other site 1310115009750 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1310115009751 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1310115009752 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1310115009753 catalytic loop [active] 1310115009754 iron binding site [ion binding]; other site 1310115009755 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1310115009756 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1310115009757 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1310115009758 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1310115009759 active site 1310115009760 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310115009761 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310115009762 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1310115009763 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1310115009764 DNA binding site [nucleotide binding] 1310115009765 domain linker motif; other site 1310115009766 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 1310115009767 putative dimerization interface [polypeptide binding]; other site 1310115009768 putative ligand binding site [chemical binding]; other site 1310115009769 PknH-like extracellular domain; Region: PknH_C; pfam14032 1310115009770 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1310115009771 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1310115009772 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1310115009773 transmembrane helices; other site 1310115009774 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1310115009775 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1310115009776 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1310115009777 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1310115009778 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1310115009779 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1310115009780 active site 1310115009781 HIGH motif; other site 1310115009782 nucleotide binding site [chemical binding]; other site 1310115009783 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1310115009784 KMSKS motif; other site 1310115009785 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1310115009786 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1310115009787 homotrimer interaction site [polypeptide binding]; other site 1310115009788 zinc binding site [ion binding]; other site 1310115009789 CDP-binding sites; other site 1310115009790 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1310115009791 substrate binding site; other site 1310115009792 dimer interface; other site 1310115009793 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 1310115009794 DNA repair protein RadA; Provisional; Region: PRK11823 1310115009795 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1310115009796 Walker A motif/ATP binding site; other site 1310115009797 ATP binding site [chemical binding]; other site 1310115009798 Walker B motif; other site 1310115009799 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1310115009800 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 1310115009801 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1310115009802 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 1310115009803 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 1310115009804 active site clefts [active] 1310115009805 zinc binding site [ion binding]; other site 1310115009806 dimer interface [polypeptide binding]; other site 1310115009807 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1310115009808 endonuclease III; Region: ENDO3c; smart00478 1310115009809 minor groove reading motif; other site 1310115009810 helix-hairpin-helix signature motif; other site 1310115009811 substrate binding pocket [chemical binding]; other site 1310115009812 active site 1310115009813 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1310115009814 PE family; Region: PE; pfam00934 1310115009815 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1310115009816 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1310115009817 catalytic site [active] 1310115009818 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1310115009819 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 1310115009820 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1310115009821 Ami_2 domain; Region: Ami_2; smart00644 1310115009822 amidase catalytic site [active] 1310115009823 Zn binding residues [ion binding]; other site 1310115009824 substrate binding site [chemical binding]; other site 1310115009825 PE family; Region: PE; pfam00934 1310115009826 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1310115009827 Clp amino terminal domain; Region: Clp_N; pfam02861 1310115009828 Clp amino terminal domain; Region: Clp_N; pfam02861 1310115009829 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1310115009830 Walker A motif; other site 1310115009831 ATP binding site [chemical binding]; other site 1310115009832 Walker B motif; other site 1310115009833 arginine finger; other site 1310115009834 UvrB/uvrC motif; Region: UVR; pfam02151 1310115009835 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1310115009836 Walker A motif; other site 1310115009837 ATP binding site [chemical binding]; other site 1310115009838 Walker B motif; other site 1310115009839 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1310115009840 Lsr2; Region: Lsr2; pfam11774 1310115009841 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1310115009842 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1310115009843 dimer interface [polypeptide binding]; other site 1310115009844 putative anticodon binding site; other site 1310115009845 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1310115009846 motif 1; other site 1310115009847 dimer interface [polypeptide binding]; other site 1310115009848 active site 1310115009849 motif 2; other site 1310115009850 motif 3; other site 1310115009851 pantothenate kinase; Reviewed; Region: PRK13318 1310115009852 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1310115009853 tetramerization interface [polypeptide binding]; other site 1310115009854 active site 1310115009855 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1310115009856 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1310115009857 active site 1310115009858 ATP-binding site [chemical binding]; other site 1310115009859 pantoate-binding site; other site 1310115009860 HXXH motif; other site 1310115009861 Rossmann-like domain; Region: Rossmann-like; pfam10727 1310115009862 Uncharacterized conserved protein [Function unknown]; Region: COG5495 1310115009863 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 1310115009864 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 1310115009865 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1310115009866 catalytic center binding site [active] 1310115009867 ATP binding site [chemical binding]; other site 1310115009868 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1310115009869 homooctamer interface [polypeptide binding]; other site 1310115009870 active site 1310115009871 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1310115009872 dihydropteroate synthase; Region: DHPS; TIGR01496 1310115009873 substrate binding pocket [chemical binding]; other site 1310115009874 dimer interface [polypeptide binding]; other site 1310115009875 inhibitor binding site; inhibition site 1310115009876 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1310115009877 homodecamer interface [polypeptide binding]; other site 1310115009878 GTP cyclohydrolase I; Provisional; Region: PLN03044 1310115009879 active site 1310115009880 putative catalytic site residues [active] 1310115009881 zinc binding site [ion binding]; other site 1310115009882 GTP-CH-I/GFRP interaction surface; other site 1310115009883 FtsH Extracellular; Region: FtsH_ext; pfam06480 1310115009884 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1310115009885 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1310115009886 Walker A motif; other site 1310115009887 ATP binding site [chemical binding]; other site 1310115009888 Walker B motif; other site 1310115009889 arginine finger; other site 1310115009890 Peptidase family M41; Region: Peptidase_M41; pfam01434 1310115009891 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 1310115009892 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1310115009893 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1310115009894 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1310115009895 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1310115009896 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1310115009897 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1310115009898 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115009899 PPE family; Region: PPE; pfam00823 1310115009900 PE family; Region: PE; pfam00934 1310115009901 Uncharacterized conserved protein [Function unknown]; Region: COG2968 1310115009902 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 1310115009903 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1310115009904 active site 1310115009905 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1310115009906 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1310115009907 Ligand Binding Site [chemical binding]; other site 1310115009908 Uncharacterized conserved protein [Function unknown]; Region: COG5282 1310115009909 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 1310115009910 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113 1310115009911 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1310115009912 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1310115009913 dimer interface [polypeptide binding]; other site 1310115009914 substrate binding site [chemical binding]; other site 1310115009915 metal binding sites [ion binding]; metal-binding site 1310115009916 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2899 1310115009917 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1310115009918 Ligand binding site; other site 1310115009919 Putative Catalytic site; other site 1310115009920 DXD motif; other site 1310115009921 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 1310115009922 Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5285 1310115009923 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1310115009924 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310115009925 NAD(P) binding site [chemical binding]; other site 1310115009926 active site 1310115009927 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1310115009928 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 1310115009929 Integrase core domain; Region: rve; pfam00665 1310115009930 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1310115009931 transposase; Provisional; Region: PRK06526 1310115009932 IstB-like ATP binding protein; Region: IstB_IS21; pfam01695 1310115009933 Walker B motif; other site 1310115009934 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1310115009935 MULE transposase domain; Region: MULE; pfam10551 1310115009936 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 1310115009937 Fic/DOC family; Region: Fic; cl00960 1310115009938 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 1310115009939 DNA polymerase III subunit delta'; Validated; Region: PRK07940 1310115009940 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1310115009941 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1310115009942 dimerization interface [polypeptide binding]; other site 1310115009943 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1310115009944 cyclase homology domain; Region: CHD; cd07302 1310115009945 nucleotidyl binding site; other site 1310115009946 metal binding site [ion binding]; metal-binding site 1310115009947 dimer interface [polypeptide binding]; other site 1310115009948 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1310115009949 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1310115009950 active site 1310115009951 interdomain interaction site; other site 1310115009952 putative metal-binding site [ion binding]; other site 1310115009953 nucleotide binding site [chemical binding]; other site 1310115009954 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 1310115009955 domain I; other site 1310115009956 phosphate binding site [ion binding]; other site 1310115009957 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1310115009958 domain II; other site 1310115009959 domain III; other site 1310115009960 nucleotide binding site [chemical binding]; other site 1310115009961 DNA binding groove [nucleotide binding] 1310115009962 catalytic site [active] 1310115009963 domain IV; other site 1310115009964 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1310115009965 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1310115009966 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1310115009967 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1310115009968 DNA-binding site [nucleotide binding]; DNA binding site 1310115009969 RNA-binding motif; other site 1310115009970 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 1310115009971 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1310115009972 ATP binding site [chemical binding]; other site 1310115009973 putative Mg++ binding site [ion binding]; other site 1310115009974 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1310115009975 nucleotide binding region [chemical binding]; other site 1310115009976 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1310115009977 PE family; Region: PE; pfam00934 1310115009978 PE family; Region: PE; pfam00934 1310115009979 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 1310115009980 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1310115009981 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1310115009982 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1310115009983 Walker A motif; other site 1310115009984 hexamer interface [polypeptide binding]; other site 1310115009985 ATP binding site [chemical binding]; other site 1310115009986 Walker B motif; other site 1310115009987 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 1310115009988 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1310115009989 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1310115009990 motif II; other site 1310115009991 potential frameshift: common BLAST hit: gi|471339745|ref|YP_007612458.1| peptide ABC transporter ATP-binding protein 1310115009992 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1310115009993 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1310115009994 ABC-ATPase subunit interface; other site 1310115009995 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1310115009996 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1310115009997 dimer interface [polypeptide binding]; other site 1310115009998 conserved gate region; other site 1310115009999 ABC-ATPase subunit interface; other site 1310115010000 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1310115010001 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1310115010002 acetyl-CoA synthetase; Provisional; Region: PRK00174 1310115010003 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1310115010004 active site 1310115010005 CoA binding site [chemical binding]; other site 1310115010006 acyl-activating enzyme (AAE) consensus motif; other site 1310115010007 AMP binding site [chemical binding]; other site 1310115010008 acetate binding site [chemical binding]; other site 1310115010009 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 1310115010010 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1310115010011 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1310115010012 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1310115010013 putative active site [active] 1310115010014 putative CoA binding site [chemical binding]; other site 1310115010015 nudix motif; other site 1310115010016 metal binding site [ion binding]; metal-binding site 1310115010017 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1310115010018 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1310115010019 catalytic residues [active] 1310115010020 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1310115010021 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1310115010022 minor groove reading motif; other site 1310115010023 helix-hairpin-helix signature motif; other site 1310115010024 substrate binding pocket [chemical binding]; other site 1310115010025 active site 1310115010026 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1310115010027 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1310115010028 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1310115010029 ligand binding site [chemical binding]; other site 1310115010030 flexible hinge region; other site 1310115010031 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1310115010032 putative switch regulator; other site 1310115010033 non-specific DNA interactions [nucleotide binding]; other site 1310115010034 DNA binding site [nucleotide binding] 1310115010035 sequence specific DNA binding site [nucleotide binding]; other site 1310115010036 putative cAMP binding site [chemical binding]; other site 1310115010037 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1310115010038 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1310115010039 homotrimer interaction site [polypeptide binding]; other site 1310115010040 putative active site [active] 1310115010041 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1310115010042 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1310115010043 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1310115010044 P loop; other site 1310115010045 Nucleotide binding site [chemical binding]; other site 1310115010046 DTAP/Switch II; other site 1310115010047 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1310115010048 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1310115010049 DTAP/Switch II; other site 1310115010050 Switch I; other site 1310115010051 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1310115010052 Transcription factor WhiB; Region: Whib; pfam02467 1310115010053 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1310115010054 Transglycosylase; Region: Transgly; pfam00912 1310115010055 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1310115010056 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1310115010057 phosphodiesterase YaeI; Provisional; Region: PRK11340 1310115010058 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1310115010059 putative active site [active] 1310115010060 putative metal binding site [ion binding]; other site 1310115010061 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1310115010062 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1310115010063 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1310115010064 catalytic residue [active] 1310115010065 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1310115010066 Cytochrome P450; Region: p450; cl12078 1310115010067 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1310115010068 anti sigma factor interaction site; other site 1310115010069 regulatory phosphorylation site [posttranslational modification]; other site 1310115010070 Uncharacterized conserved protein [Function unknown]; Region: COG1610 1310115010071 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1310115010072 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 1310115010073 MoxR-like ATPases [General function prediction only]; Region: COG0714 1310115010074 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1310115010075 Walker A motif; other site 1310115010076 ATP binding site [chemical binding]; other site 1310115010077 Walker B motif; other site 1310115010078 arginine finger; other site 1310115010079 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1310115010080 Protein of unknown function DUF58; Region: DUF58; pfam01882 1310115010081 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 1310115010082 Predicted membrane protein/domain [Function unknown]; Region: COG1714 1310115010083 glycerol kinase; Provisional; Region: glpK; PRK00047 1310115010084 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1310115010085 nucleotide binding site [chemical binding]; other site 1310115010086 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1310115010087 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1310115010088 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1310115010089 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310115010090 S-adenosylmethionine binding site [chemical binding]; other site 1310115010091 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1310115010092 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1310115010093 catalytic residue [active] 1310115010094 Uncharacterized conserved protein [Function unknown]; Region: COG4301 1310115010095 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 1310115010096 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 1310115010097 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1310115010098 putative active site [active] 1310115010099 putative dimer interface [polypeptide binding]; other site 1310115010100 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 1310115010101 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1310115010102 Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG3572 1310115010103 PknH-like extracellular domain; Region: PknH_C; pfam14032 1310115010104 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 1310115010105 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1310115010106 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1310115010107 aspartate kinase; Reviewed; Region: PRK06635 1310115010108 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1310115010109 putative nucleotide binding site [chemical binding]; other site 1310115010110 putative catalytic residues [active] 1310115010111 putative Mg ion binding site [ion binding]; other site 1310115010112 putative aspartate binding site [chemical binding]; other site 1310115010113 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1310115010114 putative allosteric regulatory site; other site 1310115010115 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1310115010116 putative allosteric regulatory residue; other site 1310115010117 2-isopropylmalate synthase; Validated; Region: PRK03739 1310115010118 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1310115010119 active site 1310115010120 catalytic residues [active] 1310115010121 metal binding site [ion binding]; metal-binding site 1310115010122 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1310115010123 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 1310115010124 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1310115010125 active site 1310115010126 catalytic site [active] 1310115010127 substrate binding site [chemical binding]; other site 1310115010128 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1310115010129 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1310115010130 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1310115010131 catalytic triad [active] 1310115010132 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1310115010133 putative active site [active] 1310115010134 recombination protein RecR; Reviewed; Region: recR; PRK00076 1310115010135 RecR protein; Region: RecR; pfam02132 1310115010136 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1310115010137 putative active site [active] 1310115010138 putative metal-binding site [ion binding]; other site 1310115010139 tetramer interface [polypeptide binding]; other site 1310115010140 hypothetical protein; Validated; Region: PRK00153 1310115010141 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1310115010142 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1310115010143 active site 1310115010144 metal binding site [ion binding]; metal-binding site 1310115010145 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 1310115010146 hydrophobic ligand binding site; other site 1310115010147 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1310115010148 FAD binding domain; Region: FAD_binding_4; pfam01565 1310115010149 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1310115010150 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310115010151 S-adenosylmethionine binding site [chemical binding]; other site 1310115010152 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14952 1310115010153 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1310115010154 Walker A motif; other site 1310115010155 ATP binding site [chemical binding]; other site 1310115010156 Walker B motif; other site 1310115010157 arginine finger; other site 1310115010158 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1310115010159 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 1310115010160 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1310115010161 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1310115010162 catalytic residue [active] 1310115010163 Cutinase; Region: Cutinase; pfam01083 1310115010164 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310115010165 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1310115010166 NAD(P) binding site [chemical binding]; other site 1310115010167 active site 1310115010168 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1310115010169 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 1310115010170 putative NAD(P) binding site [chemical binding]; other site 1310115010171 catalytic Zn binding site [ion binding]; other site 1310115010172 Uncharacterized conserved protein [Function unknown]; Region: COG3349 1310115010173 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 1310115010174 potential frameshift: common BLAST hit: gi|433643918|ref|YP_007289677.1| Conserved two-domain membrane protein of unknown function 1310115010175 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 1310115010176 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1310115010177 FeS/SAM binding site; other site 1310115010178 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1310115010179 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310115010180 S-adenosylmethionine binding site [chemical binding]; other site 1310115010181 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 1310115010182 nucleotide binding site [chemical binding]; other site 1310115010183 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 1310115010184 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 1310115010185 active site 1310115010186 DNA binding site [nucleotide binding] 1310115010187 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 1310115010188 DNA binding site [nucleotide binding] 1310115010189 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4402 1310115010190 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_5; cd04662 1310115010191 nudix motif; other site 1310115010192 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1310115010193 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1310115010194 Uncharacterized conserved protein [Function unknown]; Region: COG1839 1310115010195 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1310115010196 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1310115010197 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1310115010198 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1310115010199 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1310115010200 Uncharacterized conserved protein [Function unknown]; Region: COG3610 1310115010201 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115010202 PPE family; Region: PPE; pfam00823 1310115010203 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1310115010204 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1310115010205 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1310115010206 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1310115010207 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 1310115010208 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1310115010209 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1310115010210 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1310115010211 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1310115010212 dimerization interface [polypeptide binding]; other site 1310115010213 putative DNA binding site [nucleotide binding]; other site 1310115010214 putative Zn2+ binding site [ion binding]; other site 1310115010215 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3651 1310115010216 DNA binding domain, excisionase family; Region: excise; TIGR01764 1310115010217 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1310115010218 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1310115010219 nucleoside/Zn binding site; other site 1310115010220 dimer interface [polypeptide binding]; other site 1310115010221 catalytic motif [active] 1310115010222 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 1310115010223 prephenate dehydrogenase; Validated; Region: PRK06545 1310115010224 prephenate dehydrogenase; Validated; Region: PRK08507 1310115010225 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3554 1310115010226 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1310115010227 ABC-ATPase subunit interface; other site 1310115010228 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 1310115010229 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1310115010230 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1310115010231 Walker A/P-loop; other site 1310115010232 ATP binding site [chemical binding]; other site 1310115010233 Q-loop/lid; other site 1310115010234 ABC transporter signature motif; other site 1310115010235 Walker B; other site 1310115010236 D-loop; other site 1310115010237 H-loop/switch region; other site 1310115010238 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1310115010239 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 1310115010240 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1310115010241 putative active site [active] 1310115010242 putative substrate binding site [chemical binding]; other site 1310115010243 ATP binding site [chemical binding]; other site 1310115010244 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 1310115010245 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1310115010246 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 1310115010247 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1310115010248 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1310115010249 dimerization interface [polypeptide binding]; other site 1310115010250 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1310115010251 dimer interface [polypeptide binding]; other site 1310115010252 phosphorylation site [posttranslational modification] 1310115010253 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1310115010254 ATP binding site [chemical binding]; other site 1310115010255 Mg2+ binding site [ion binding]; other site 1310115010256 G-X-G motif; other site 1310115010257 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1310115010258 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1310115010259 active site 1310115010260 phosphorylation site [posttranslational modification] 1310115010261 intermolecular recognition site; other site 1310115010262 dimerization interface [polypeptide binding]; other site 1310115010263 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1310115010264 DNA binding site [nucleotide binding] 1310115010265 Photosystem II reaction centre W protein (PsbW); Region: PsbW; cl06243 1310115010266 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1310115010267 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1310115010268 SnoaL-like domain; Region: SnoaL_2; pfam12680 1310115010269 potential frameshift: common BLAST hit: gi|449065888|ref|YP_007432971.1| aminotransferase 1310115010270 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1310115010271 TIGR03086 family protein; Region: TIGR03086 1310115010272 enoyl-CoA hydratase; Provisional; Region: PRK06142 1310115010273 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1310115010274 substrate binding site [chemical binding]; other site 1310115010275 oxyanion hole (OAH) forming residues; other site 1310115010276 trimer interface [polypeptide binding]; other site 1310115010277 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1310115010278 Beta-lactamase; Region: Beta-lactamase; pfam00144 1310115010279 potential protein location (hypothetical protein J114_20175 [Mycobacterium tuberculosis EAI5/NITR206]) that overlaps RNA (tRNA-S) 1310115010280 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1310115010281 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1310115010282 NAD(P) binding site [chemical binding]; other site 1310115010283 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1310115010284 cysteine desulfurase family protein, VC1184 subfamily; Region: am_tr_V_VC1184; TIGR01976 1310115010285 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1310115010286 catalytic residue [active] 1310115010287 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 1310115010288 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1310115010289 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1310115010290 Walker A/P-loop; other site 1310115010291 ATP binding site [chemical binding]; other site 1310115010292 Q-loop/lid; other site 1310115010293 ABC transporter signature motif; other site 1310115010294 Walker B; other site 1310115010295 D-loop; other site 1310115010296 H-loop/switch region; other site 1310115010297 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1310115010298 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1310115010299 active site 1310115010300 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1310115010301 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1310115010302 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1310115010303 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 1310115010304 NAD binding site [chemical binding]; other site 1310115010305 substrate binding site [chemical binding]; other site 1310115010306 active site 1310115010307 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1310115010308 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 1310115010309 active site 1310115010310 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1310115010311 Peptidase family M23; Region: Peptidase_M23; pfam01551 1310115010312 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1310115010313 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1310115010314 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05892 1310115010315 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1310115010316 Predicted membrane protein [Function unknown]; Region: COG2246 1310115010317 GtrA-like protein; Region: GtrA; pfam04138 1310115010318 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1310115010319 FAD binding domain; Region: FAD_binding_4; pfam01565 1310115010320 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1310115010321 short chain dehydrogenase; Provisional; Region: PRK07904 1310115010322 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1310115010323 NAD(P) binding site [chemical binding]; other site 1310115010324 active site 1310115010325 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 1310115010326 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 1310115010327 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1310115010328 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1310115010329 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1310115010330 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1310115010331 potential frameshift: common BLAST hit: gi|471339891|ref|YP_007612604.1| acyl-CoA dehydrogenase 1310115010332 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1310115010333 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1310115010334 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1310115010335 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1310115010336 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1310115010337 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1310115010338 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1310115010339 active site 1310115010340 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1310115010341 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1310115010342 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1310115010343 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1310115010344 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1310115010345 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1310115010346 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1310115010347 active site 1310115010348 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1310115010349 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 1310115010350 acyl-activating enzyme (AAE) consensus motif; other site 1310115010351 active site 1310115010352 Cutinase; Region: Cutinase; pfam01083 1310115010353 Predicted esterase [General function prediction only]; Region: COG0627 1310115010354 Putative esterase; Region: Esterase; pfam00756 1310115010355 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 1310115010356 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1310115010357 active site 1310115010358 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1310115010359 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1310115010360 active site 1310115010361 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 1310115010362 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1310115010363 UDP-galactopyranose mutase; Region: GLF; pfam03275 1310115010364 PE family; Region: PE; pfam00934 1310115010365 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1310115010366 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1310115010367 active site 1310115010368 motif I; other site 1310115010369 motif II; other site 1310115010370 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1310115010371 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1310115010372 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1310115010373 putative acyl-acceptor binding pocket; other site 1310115010374 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1310115010375 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1310115010376 putative acyl-acceptor binding pocket; other site 1310115010377 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1310115010378 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1310115010379 putative acyl-acceptor binding pocket; other site 1310115010380 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 1310115010381 Phosphotransferase enzyme family; Region: APH; pfam01636 1310115010382 active site 1310115010383 ATP binding site [chemical binding]; other site 1310115010384 antibiotic binding site [chemical binding]; other site 1310115010385 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1310115010386 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1310115010387 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1310115010388 iron-sulfur cluster [ion binding]; other site 1310115010389 [2Fe-2S] cluster binding site [ion binding]; other site 1310115010390 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1310115010391 PE-PPE domain; Region: PE-PPE; pfam08237 1310115010392 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1310115010393 Condensation domain; Region: Condensation; pfam00668 1310115010394 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1310115010395 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1310115010396 active site 1310115010397 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1310115010398 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1310115010399 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310115010400 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1310115010401 Enoylreductase; Region: PKS_ER; smart00829 1310115010402 NAD(P) binding site [chemical binding]; other site 1310115010403 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1310115010404 KR domain; Region: KR; pfam08659 1310115010405 putative NADP binding site [chemical binding]; other site 1310115010406 active site 1310115010407 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1310115010408 acyl-CoA synthetase; Validated; Region: PRK05850 1310115010409 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1310115010410 acyl-activating enzyme (AAE) consensus motif; other site 1310115010411 active site 1310115010412 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1310115010413 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1310115010414 Probable transposase; Region: OrfB_IS605; pfam01385 1310115010415 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1310115010416 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 1310115010417 catalytic residues [active] 1310115010418 catalytic nucleophile [active] 1310115010419 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1310115010420 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1310115010421 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1310115010422 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310115010423 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 1310115010424 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310115010425 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1310115010426 Cupin domain; Region: Cupin_2; cl17218 1310115010427 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1310115010428 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1310115010429 seryl-tRNA synthetase; Provisional; Region: PRK05431 1310115010430 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1310115010431 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1310115010432 dimer interface [polypeptide binding]; other site 1310115010433 active site 1310115010434 motif 1; other site 1310115010435 motif 2; other site 1310115010436 motif 3; other site 1310115010437 Septum formation; Region: Septum_form; pfam13845 1310115010438 Septum formation; Region: Septum_form; pfam13845 1310115010439 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 1310115010440 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1310115010441 catalytic core [active] 1310115010442 Prephenate dehydratase; Region: PDT; pfam00800 1310115010443 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1310115010444 putative L-Phe binding site [chemical binding]; other site 1310115010445 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1310115010446 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1310115010447 Ferritin-like domain; Region: Ferritin; pfam00210 1310115010448 ferroxidase diiron center [ion binding]; other site 1310115010449 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 1310115010450 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1310115010451 putative active site [active] 1310115010452 catalytic site [active] 1310115010453 putative metal binding site [ion binding]; other site 1310115010454 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 1310115010455 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1310115010456 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1310115010457 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1310115010458 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1310115010459 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1310115010460 Predicted membrane protein [Function unknown]; Region: COG2119 1310115010461 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1310115010462 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1310115010463 Fimbrial protein; Region: Fimbrial; cl01416 1310115010464 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1310115010465 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1310115010466 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1310115010467 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310115010468 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310115010469 hypothetical protein; Provisional; Region: PRK07945 1310115010470 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1310115010471 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 1310115010472 active site 1310115010473 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1310115010474 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1310115010475 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1310115010476 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1310115010477 active site 1310115010478 dimer interface [polypeptide binding]; other site 1310115010479 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1310115010480 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1310115010481 active site 1310115010482 FMN binding site [chemical binding]; other site 1310115010483 substrate binding site [chemical binding]; other site 1310115010484 3Fe-4S cluster binding site [ion binding]; other site 1310115010485 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1310115010486 domain interface; other site 1310115010487 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1310115010488 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1310115010489 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 1310115010490 EspG family; Region: ESX-1_EspG; pfam14011 1310115010491 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1310115010492 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1310115010493 Walker A motif; other site 1310115010494 ATP binding site [chemical binding]; other site 1310115010495 Walker B motif; other site 1310115010496 arginine finger; other site 1310115010497 Protein of unknown function (DUF690); Region: DUF690; pfam05108 1310115010498 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1310115010499 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1310115010500 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1310115010501 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1310115010502 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1310115010503 PE family; Region: PE; pfam00934 1310115010504 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310115010505 PPE family; Region: PPE; pfam00823 1310115010506 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1310115010507 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1310115010508 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1310115010509 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1310115010510 potential frameshift: common BLAST hit: gi|433629023|ref|YP_007262652.1| ESX-1 secretion-associated protein EspJ 1310115010511 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 1310115010512 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1310115010513 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1310115010514 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1310115010515 active site 1310115010516 catalytic residues [active] 1310115010517 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1310115010518 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1310115010519 Walker A motif; other site 1310115010520 ATP binding site [chemical binding]; other site 1310115010521 Walker B motif; other site 1310115010522 arginine finger; other site 1310115010523 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1310115010524 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1310115010525 catalytic residues [active] 1310115010526 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1310115010527 active site 1310115010528 catalytic residues [active] 1310115010529 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1310115010530 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1310115010531 EspG family; Region: ESX-1_EspG; pfam14011 1310115010532 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1310115010533 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1310115010534 PPE family; Region: PPE; pfam00823 1310115010535 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1310115010536 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1310115010537 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1310115010538 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1310115010539 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1310115010540 Protein of unknown function (DUF690); Region: DUF690; pfam05108 1310115010541 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1310115010542 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1310115010543 catalytic residue [active] 1310115010544 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 1310115010545 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1310115010546 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 1310115010547 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1310115010548 active site 1310115010549 NTP binding site [chemical binding]; other site 1310115010550 metal binding triad [ion binding]; metal-binding site 1310115010551 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1310115010552 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1310115010553 Zn2+ binding site [ion binding]; other site 1310115010554 Mg2+ binding site [ion binding]; other site 1310115010555 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1310115010556 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1310115010557 active site 1310115010558 Ap6A binding site [chemical binding]; other site 1310115010559 nudix motif; other site 1310115010560 metal binding site [ion binding]; metal-binding site 1310115010561 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1310115010562 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1310115010563 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 1310115010564 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1310115010565 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1310115010566 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1310115010567 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1310115010568 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1310115010569 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1310115010570 catalytic residues [active] 1310115010571 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1310115010572 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1310115010573 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1310115010574 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1310115010575 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1310115010576 active site 1310115010577 metal binding site [ion binding]; metal-binding site 1310115010578 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1310115010579 ParB-like nuclease domain; Region: ParB; smart00470 1310115010580 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1310115010581 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1310115010582 P-loop; other site 1310115010583 Magnesium ion binding site [ion binding]; other site 1310115010584 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1310115010585 Magnesium ion binding site [ion binding]; other site 1310115010586 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 1310115010587 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1310115010588 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1310115010589 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1310115010590 G-X-X-G motif; other site 1310115010591 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1310115010592 RxxxH motif; other site 1310115010593 potential frameshift: common BLAST hit: gi|433637018|ref|YP_007270645.1| Putative OxaA-like inner membrane protein translocase component 1310115010594 Uncharacterized conserved protein [Function unknown]; Region: COG0759 1310115010595 ribonuclease P; Reviewed; Region: rnpA; PRK00588 1310115010596 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399