-- dump date 20140619_154349 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1306414000001 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1306414000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1306414000003 Walker A motif; other site 1306414000004 ATP binding site [chemical binding]; other site 1306414000005 Walker B motif; other site 1306414000006 arginine finger; other site 1306414000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1306414000008 DnaA box-binding interface [nucleotide binding]; other site 1306414000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 1306414000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1306414000011 putative DNA binding surface [nucleotide binding]; other site 1306414000012 dimer interface [polypeptide binding]; other site 1306414000013 beta-clamp/clamp loader binding surface; other site 1306414000014 beta-clamp/translesion DNA polymerase binding surface; other site 1306414000015 recF protein; Region: recf; TIGR00611 1306414000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1306414000017 Walker A/P-loop; other site 1306414000018 ATP binding site [chemical binding]; other site 1306414000019 Q-loop/lid; other site 1306414000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1306414000021 ABC transporter signature motif; other site 1306414000022 Walker B; other site 1306414000023 D-loop; other site 1306414000024 H-loop/switch region; other site 1306414000025 hypothetical protein; Provisional; Region: PRK03195 1306414000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1306414000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1306414000028 Mg2+ binding site [ion binding]; other site 1306414000029 G-X-G motif; other site 1306414000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1306414000031 anchoring element; other site 1306414000032 dimer interface [polypeptide binding]; other site 1306414000033 ATP binding site [chemical binding]; other site 1306414000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1306414000035 active site 1306414000036 putative metal-binding site [ion binding]; other site 1306414000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1306414000038 DNA gyrase subunit A; Validated; Region: PRK05560 1306414000039 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1306414000040 CAP-like domain; other site 1306414000041 active site 1306414000042 primary dimer interface [polypeptide binding]; other site 1306414000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1306414000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1306414000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1306414000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1306414000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1306414000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1306414000049 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 1306414000050 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 1306414000051 Protein of unknown function (DUF2562); Region: DUF2562; pfam10814 1306414000052 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1306414000053 active site 1306414000054 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1306414000055 putative septation inhibitor protein; Reviewed; Region: PRK00159 1306414000056 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1306414000057 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1306414000058 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1306414000059 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1306414000060 glutamine binding [chemical binding]; other site 1306414000061 catalytic triad [active] 1306414000062 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1306414000063 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1306414000064 active site 1306414000065 ATP binding site [chemical binding]; other site 1306414000066 substrate binding site [chemical binding]; other site 1306414000067 activation loop (A-loop); other site 1306414000068 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1306414000069 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1306414000070 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1306414000071 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1306414000072 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1306414000073 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1306414000074 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1306414000075 active site 1306414000076 ATP binding site [chemical binding]; other site 1306414000077 substrate binding site [chemical binding]; other site 1306414000078 activation loop (A-loop); other site 1306414000079 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1306414000080 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1306414000081 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1306414000082 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1306414000083 active site 1306414000084 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1306414000085 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1306414000086 phosphopeptide binding site; other site 1306414000087 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 1306414000088 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1306414000089 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1306414000090 phosphopeptide binding site; other site 1306414000091 Nitronate monooxygenase; Region: NMO; pfam03060 1306414000092 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1306414000093 FMN binding site [chemical binding]; other site 1306414000094 substrate binding site [chemical binding]; other site 1306414000095 putative catalytic residue [active] 1306414000096 Transcription factor WhiB; Region: Whib; pfam02467 1306414000097 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1306414000098 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1306414000099 non-specific DNA binding site [nucleotide binding]; other site 1306414000100 salt bridge; other site 1306414000101 sequence-specific DNA binding site [nucleotide binding]; other site 1306414000102 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1306414000103 NlpC/P60 family; Region: NLPC_P60; pfam00877 1306414000104 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 1306414000105 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 1306414000106 Protein of unknown function (DUF2694); Region: DUF2694; pfam10904 1306414000107 Protein of unknown function (DUF2710); Region: DUF2710; pfam10921 1306414000108 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1306414000109 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 1306414000110 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1306414000111 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1306414000112 catalytic residue [active] 1306414000113 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1306414000114 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 1306414000115 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1306414000116 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1306414000117 acyl-activating enzyme (AAE) consensus motif; other site 1306414000118 active site 1306414000119 TIGR03084 family protein; Region: TIGR03084 1306414000120 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1306414000121 Wyosine base formation; Region: Wyosine_form; pfam08608 1306414000122 H+ Antiporter protein; Region: 2A0121; TIGR00900 1306414000123 hypothetical protein; Validated; Region: PRK00228 1306414000124 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 1306414000125 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1306414000126 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1306414000127 active site 1306414000128 HIGH motif; other site 1306414000129 nucleotide binding site [chemical binding]; other site 1306414000130 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1306414000131 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1306414000132 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1306414000133 active site 1306414000134 KMSKS motif; other site 1306414000135 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1306414000136 tRNA binding surface [nucleotide binding]; other site 1306414000137 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1306414000138 MarR family; Region: MarR; pfam01047 1306414000139 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1306414000140 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1306414000141 DNA-binding site [nucleotide binding]; DNA binding site 1306414000142 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 1306414000143 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1306414000144 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1306414000145 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 1306414000146 inositol 1-phosphate synthase, Actinobacterial type; Region: mycothiol_INO1; TIGR03450 1306414000147 Predicted transcriptional regulators [Transcription]; Region: COG1695 1306414000148 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1306414000149 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1306414000150 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1306414000151 Transglycosylase; Region: Transgly; pfam00912 1306414000152 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1306414000153 Predicted integral membrane protein [Function unknown]; Region: COG5650 1306414000154 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1306414000155 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1306414000156 conserved cys residue [active] 1306414000157 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1306414000158 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1306414000159 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1306414000160 dimer interface [polypeptide binding]; other site 1306414000161 ssDNA binding site [nucleotide binding]; other site 1306414000162 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1306414000163 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1306414000164 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1306414000165 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1306414000166 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1306414000167 replicative DNA helicase; Validated; Region: PRK07773 1306414000168 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1306414000169 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1306414000170 Walker A motif; other site 1306414000171 ATP binding site [chemical binding]; other site 1306414000172 Walker B motif; other site 1306414000173 DNA binding loops [nucleotide binding] 1306414000174 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1306414000175 protein-splicing catalytic site; other site 1306414000176 thioester formation/cholesterol transfer; other site 1306414000177 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1306414000178 protein-splicing catalytic site; other site 1306414000179 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1306414000180 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 1306414000181 ADP-ribose binding site [chemical binding]; other site 1306414000182 Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1 [General function prediction only]; Region: COG2110 1306414000183 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 1306414000184 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1306414000185 FAD binding domain; Region: FAD_binding_4; pfam01565 1306414000186 Berberine and berberine like; Region: BBE; pfam08031 1306414000187 hypothetical protein; Provisional; Region: PRK12438 1306414000188 hypothetical protein; Validated; Region: PRK00068 1306414000189 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1306414000190 homotetrameric interface [polypeptide binding]; other site 1306414000191 putative active site [active] 1306414000192 metal binding site [ion binding]; metal-binding site 1306414000193 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 1306414000194 Monomeric isocitrate dehydrogenase; Region: IDH; pfam03971 1306414000195 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306414000196 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306414000197 short chain dehydrogenase; Provisional; Region: PRK06197 1306414000198 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1306414000199 putative NAD(P) binding site [chemical binding]; other site 1306414000200 active site 1306414000201 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1306414000202 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1306414000203 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1306414000204 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1306414000205 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1306414000206 dimer interface [polypeptide binding]; other site 1306414000207 active site 1306414000208 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1306414000209 folate binding site [chemical binding]; other site 1306414000210 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1306414000211 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1306414000212 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1306414000213 Walker A/P-loop; other site 1306414000214 ATP binding site [chemical binding]; other site 1306414000215 Q-loop/lid; other site 1306414000216 ABC transporter signature motif; other site 1306414000217 Walker B; other site 1306414000218 D-loop; other site 1306414000219 H-loop/switch region; other site 1306414000220 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1306414000221 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1306414000222 ligand binding site [chemical binding]; other site 1306414000223 flexible hinge region; other site 1306414000224 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1306414000225 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1306414000226 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1306414000227 homodimer interface [polypeptide binding]; other site 1306414000228 catalytic residue [active] 1306414000229 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1306414000230 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306414000231 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306414000232 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1306414000233 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1306414000234 dimerization interface [polypeptide binding]; other site 1306414000235 putative DNA binding site [nucleotide binding]; other site 1306414000236 putative Zn2+ binding site [ion binding]; other site 1306414000237 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 1306414000238 hydrogenase 4 subunit B; Validated; Region: PRK06521 1306414000239 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1306414000240 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1306414000241 NADH dehydrogenase; Region: NADHdh; cl00469 1306414000242 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; COG4237 1306414000243 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1306414000244 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 1306414000245 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 1306414000246 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 1306414000247 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 1306414000248 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 1306414000249 putative hydrophobic ligand binding site [chemical binding]; other site 1306414000250 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306414000251 S-adenosylmethionine binding site [chemical binding]; other site 1306414000252 Predicted membrane protein [Function unknown]; Region: COG3305 1306414000253 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1306414000254 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1306414000255 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1306414000256 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1306414000257 metal-binding site [ion binding] 1306414000258 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1306414000259 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1306414000260 Predicted integral membrane protein [Function unknown]; Region: COG5660 1306414000261 Putative zinc-finger; Region: zf-HC2; pfam13490 1306414000262 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306414000263 PPE family; Region: PPE; pfam00823 1306414000264 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1306414000265 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 1306414000266 FcoT-like thioesterase domain; Region: FcoT; pfam10862 1306414000267 acyl-CoA synthetase; Validated; Region: PRK05857 1306414000268 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1306414000269 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 1306414000270 acyl-activating enzyme (AAE) consensus motif; other site 1306414000271 acyl-activating enzyme (AAE) consensus motif; other site 1306414000272 AMP binding site [chemical binding]; other site 1306414000273 active site 1306414000274 CoA binding site [chemical binding]; other site 1306414000275 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1306414000276 AMP-binding enzyme; Region: AMP-binding; pfam00501 1306414000277 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1306414000278 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1306414000279 acyl-activating enzyme (AAE) consensus motif; other site 1306414000280 acyl-activating enzyme (AAE) consensus motif; other site 1306414000281 active site 1306414000282 AMP binding site [chemical binding]; other site 1306414000283 CoA binding site [chemical binding]; other site 1306414000284 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1306414000285 Condensation domain; Region: Condensation; pfam00668 1306414000286 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1306414000287 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1306414000288 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1306414000289 acyl-activating enzyme (AAE) consensus motif; other site 1306414000290 AMP binding site [chemical binding]; other site 1306414000291 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1306414000292 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 1306414000293 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1306414000294 putative NAD(P) binding site [chemical binding]; other site 1306414000295 active site 1306414000296 putative substrate binding site [chemical binding]; other site 1306414000297 Predicted membrane protein [Function unknown]; Region: COG3336 1306414000298 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1306414000299 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1306414000300 metal-binding site [ion binding] 1306414000301 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1306414000302 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1306414000303 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1306414000304 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1306414000305 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1306414000306 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1306414000307 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1306414000308 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1306414000309 motif II; other site 1306414000310 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1306414000311 Rhomboid family; Region: Rhomboid; pfam01694 1306414000312 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1306414000313 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1306414000314 active site 1306414000315 catalytic triad [active] 1306414000316 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1306414000317 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1306414000318 NADP-binding site; other site 1306414000319 homotetramer interface [polypeptide binding]; other site 1306414000320 substrate binding site [chemical binding]; other site 1306414000321 homodimer interface [polypeptide binding]; other site 1306414000322 active site 1306414000323 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1306414000324 dimer interface [polypeptide binding]; other site 1306414000325 active site 1306414000326 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 1306414000327 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1306414000328 active site 1306414000329 motif I; other site 1306414000330 motif II; other site 1306414000331 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1306414000332 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1306414000333 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1306414000334 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1306414000335 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1306414000336 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1306414000337 dimerization interface [polypeptide binding]; other site 1306414000338 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 1306414000339 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1306414000340 PYR/PP interface [polypeptide binding]; other site 1306414000341 dimer interface [polypeptide binding]; other site 1306414000342 TPP binding site [chemical binding]; other site 1306414000343 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1306414000344 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 1306414000345 TPP-binding site; other site 1306414000346 dimer interface [polypeptide binding]; other site 1306414000347 acyl-CoA synthetase; Validated; Region: PRK05852 1306414000348 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1306414000349 Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926 1306414000350 acyl-activating enzyme (AAE) consensus motif; other site 1306414000351 acyl-activating enzyme (AAE) consensus motif; other site 1306414000352 putative AMP binding site [chemical binding]; other site 1306414000353 putative active site [active] 1306414000354 putative CoA binding site [chemical binding]; other site 1306414000355 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 1306414000356 elongation factor G; Reviewed; Region: PRK12740 1306414000357 G1 box; other site 1306414000358 putative GEF interaction site [polypeptide binding]; other site 1306414000359 GTP/Mg2+ binding site [chemical binding]; other site 1306414000360 Switch I region; other site 1306414000361 G2 box; other site 1306414000362 G3 box; other site 1306414000363 Switch II region; other site 1306414000364 G4 box; other site 1306414000365 G5 box; other site 1306414000366 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1306414000367 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1306414000368 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1306414000369 PPOX class probable F420-dependent enzyme, Rv0121 family; Region: Rv0121_F420; TIGR03668 1306414000370 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1306414000371 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1306414000372 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1306414000373 trehalose synthase; Region: treS_nterm; TIGR02456 1306414000374 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 1306414000375 active site 1306414000376 catalytic site [active] 1306414000377 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 1306414000378 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 1306414000379 Predicted membrane protein [Function unknown]; Region: COG3619 1306414000380 Predicted esterase [General function prediction only]; Region: COG0627 1306414000381 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 1306414000382 putative active site [active] 1306414000383 putative catalytic site [active] 1306414000384 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306414000385 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1306414000386 active site 1306414000387 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 1306414000388 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1306414000389 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1306414000390 Coenzyme A binding pocket [chemical binding]; other site 1306414000391 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1306414000392 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1306414000393 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306414000394 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306414000395 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1306414000396 Cytochrome P450; Region: p450; cl12078 1306414000397 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1306414000398 SnoaL-like domain; Region: SnoaL_2; pfam12680 1306414000399 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1306414000400 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1306414000401 NAD(P) binding site [chemical binding]; other site 1306414000402 active site 1306414000403 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 1306414000404 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 1306414000405 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1306414000406 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1306414000407 minor groove reading motif; other site 1306414000408 helix-hairpin-helix signature motif; other site 1306414000409 active site 1306414000410 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1306414000411 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1306414000412 Cl- selectivity filter; other site 1306414000413 Cl- binding residues [ion binding]; other site 1306414000414 pore gating glutamate residue; other site 1306414000415 dimer interface [polypeptide binding]; other site 1306414000416 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1306414000417 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1306414000418 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1306414000419 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1306414000420 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 1306414000421 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 1306414000422 NAD(P) binding site [chemical binding]; other site 1306414000423 catalytic residues [active] 1306414000424 short chain dehydrogenase; Provisional; Region: PRK07791 1306414000425 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 1306414000426 NAD binding site [chemical binding]; other site 1306414000427 homodimer interface [polypeptide binding]; other site 1306414000428 active site 1306414000429 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1306414000430 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 1306414000431 NAD(P) binding site [chemical binding]; other site 1306414000432 PE family; Region: PE; pfam00934 1306414000433 PE-PPE domain; Region: PE-PPE; pfam08237 1306414000434 PE-PPE domain; Region: PE-PPE; pfam08237 1306414000435 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 1306414000436 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1306414000437 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1306414000438 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306414000439 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 1306414000440 FAD binding site [chemical binding]; other site 1306414000441 substrate binding site [chemical binding]; other site 1306414000442 catalytic base [active] 1306414000443 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1306414000444 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1306414000445 ligand binding site [chemical binding]; other site 1306414000446 homodimer interface [polypeptide binding]; other site 1306414000447 NAD(P) binding site [chemical binding]; other site 1306414000448 trimer interface B [polypeptide binding]; other site 1306414000449 trimer interface A [polypeptide binding]; other site 1306414000450 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1306414000451 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1306414000452 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 1306414000453 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1306414000454 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306414000455 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306414000456 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 1306414000457 PE family; Region: PE; pfam00934 1306414000458 PE-PPE domain; Region: PE-PPE; pfam08237 1306414000459 PE family; Region: PE; pfam00934 1306414000460 PE-PPE domain; Region: PE-PPE; pfam08237 1306414000461 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1306414000462 FAD binding domain; Region: FAD_binding_4; pfam01565 1306414000463 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1306414000464 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1306414000465 NAD(P) binding site [chemical binding]; other site 1306414000466 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1306414000467 active site 1306414000468 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1306414000469 putative hydrophobic ligand binding site [chemical binding]; other site 1306414000470 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1306414000471 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1306414000472 DNA-binding site [nucleotide binding]; DNA binding site 1306414000473 FCD domain; Region: FCD; pfam07729 1306414000474 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786 1306414000475 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1306414000476 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1306414000477 acyl-activating enzyme (AAE) consensus motif; other site 1306414000478 acyl-activating enzyme (AAE) consensus motif; other site 1306414000479 putative AMP binding site [chemical binding]; other site 1306414000480 putative active site [active] 1306414000481 putative CoA binding site [chemical binding]; other site 1306414000482 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1306414000483 Permease; Region: Permease; pfam02405 1306414000484 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1306414000485 Permease; Region: Permease; pfam02405 1306414000486 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1306414000487 mce related protein; Region: MCE; pfam02470 1306414000488 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1306414000489 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1306414000490 mce related protein; Region: MCE; pfam02470 1306414000491 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1306414000492 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1306414000493 mce related protein; Region: MCE; pfam02470 1306414000494 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1306414000495 mce related protein; Region: MCE; pfam02470 1306414000496 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1306414000497 mce related protein; Region: MCE; pfam02470 1306414000498 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1306414000499 mce related protein; Region: MCE; pfam02470 1306414000500 RDD family; Region: RDD; pfam06271 1306414000501 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1306414000502 Predicted membrane protein [Function unknown]; Region: COG1511 1306414000503 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1306414000504 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1306414000505 Pirin-related protein [General function prediction only]; Region: COG1741 1306414000506 Pirin; Region: Pirin; pfam02678 1306414000507 RNA polymerase factor sigma-70; Validated; Region: PRK08241 1306414000508 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1306414000509 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1306414000510 DNA binding residues [nucleotide binding] 1306414000511 SnoaL-like domain; Region: SnoaL_2; pfam12680 1306414000512 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1306414000513 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1306414000514 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 1306414000515 putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185 1306414000516 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1306414000517 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1306414000518 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1306414000519 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1306414000520 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1306414000521 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306414000522 S-adenosylmethionine binding site [chemical binding]; other site 1306414000523 SPW repeat; Region: SPW; pfam03779 1306414000524 SPW repeat; Region: SPW; pfam03779 1306414000525 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1306414000526 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1306414000527 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1306414000528 putative homodimer interface [polypeptide binding]; other site 1306414000529 putative homotetramer interface [polypeptide binding]; other site 1306414000530 putative allosteric switch controlling residues; other site 1306414000531 putative metal binding site [ion binding]; other site 1306414000532 putative homodimer-homodimer interface [polypeptide binding]; other site 1306414000533 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1306414000534 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1306414000535 putative substrate translocation pore; other site 1306414000536 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1306414000537 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1306414000538 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1306414000539 Walker A/P-loop; other site 1306414000540 ATP binding site [chemical binding]; other site 1306414000541 Q-loop/lid; other site 1306414000542 ABC transporter signature motif; other site 1306414000543 Walker B; other site 1306414000544 D-loop; other site 1306414000545 H-loop/switch region; other site 1306414000546 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1306414000547 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1306414000548 Walker A/P-loop; other site 1306414000549 ATP binding site [chemical binding]; other site 1306414000550 Q-loop/lid; other site 1306414000551 ABC transporter signature motif; other site 1306414000552 Walker B; other site 1306414000553 D-loop; other site 1306414000554 H-loop/switch region; other site 1306414000555 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1306414000556 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1306414000557 dimerization interface [polypeptide binding]; other site 1306414000558 DNA binding residues [nucleotide binding] 1306414000559 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306414000560 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306414000561 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1306414000562 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 1306414000563 putative [Fe4-S4] binding site [ion binding]; other site 1306414000564 putative molybdopterin cofactor binding site [chemical binding]; other site 1306414000565 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1306414000566 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 1306414000567 putative molybdopterin cofactor binding site; other site 1306414000568 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1306414000569 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1306414000570 active site 1306414000571 Zn binding site [ion binding]; other site 1306414000572 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1306414000573 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 1306414000574 Predicted integral membrane protein [Function unknown]; Region: COG0392 1306414000575 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1306414000576 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1306414000577 MMPL family; Region: MMPL; pfam03176 1306414000578 MMPL family; Region: MMPL; pfam03176 1306414000579 LabA_like proteins; Region: LabA_like; cd06167 1306414000580 putative metal binding site [ion binding]; other site 1306414000581 Putative methyltransferase; Region: Methyltransf_4; pfam02390 1306414000582 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 1306414000583 active site 1306414000584 substrate-binding site [chemical binding]; other site 1306414000585 metal-binding site [ion binding] 1306414000586 GTP binding site [chemical binding]; other site 1306414000587 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 1306414000588 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 1306414000589 active site 1306414000590 (T/H)XGH motif; other site 1306414000591 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 1306414000592 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 1306414000593 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 1306414000594 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1306414000595 FeS/SAM binding site; other site 1306414000596 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 1306414000597 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1306414000598 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1306414000599 acyl-activating enzyme (AAE) consensus motif; other site 1306414000600 acyl-activating enzyme (AAE) consensus motif; other site 1306414000601 putative AMP binding site [chemical binding]; other site 1306414000602 putative active site [active] 1306414000603 putative CoA binding site [chemical binding]; other site 1306414000604 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306414000605 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1306414000606 active site 1306414000607 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 1306414000608 putative active site [active] 1306414000609 putative catalytic site [active] 1306414000610 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1306414000611 active site 2 [active] 1306414000612 active site 1 [active] 1306414000613 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1306414000614 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1306414000615 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1306414000616 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321 1306414000617 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1306414000618 Moco binding site; other site 1306414000619 metal coordination site [ion binding]; other site 1306414000620 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1306414000621 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1306414000622 enoyl-CoA hydratase; Provisional; Region: PRK08252 1306414000623 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1306414000624 substrate binding site [chemical binding]; other site 1306414000625 oxyanion hole (OAH) forming residues; other site 1306414000626 trimer interface [polypeptide binding]; other site 1306414000627 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 1306414000628 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1306414000629 NAD binding site [chemical binding]; other site 1306414000630 catalytic residues [active] 1306414000631 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306414000632 S-adenosylmethionine binding site [chemical binding]; other site 1306414000633 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1306414000634 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1306414000635 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 1306414000636 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1306414000637 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1306414000638 putative active site [active] 1306414000639 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1306414000640 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 1306414000641 active site 1306414000642 substrate binding pocket [chemical binding]; other site 1306414000643 homodimer interaction site [polypeptide binding]; other site 1306414000644 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306414000645 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1306414000646 active site 1306414000647 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306414000648 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306414000649 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 1306414000650 active site 1306414000651 diiron metal binding site [ion binding]; other site 1306414000652 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1306414000653 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1306414000654 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1306414000655 NAD(P) binding site [chemical binding]; other site 1306414000656 catalytic residues [active] 1306414000657 Lipase maturation factor; Region: LMF1; pfam06762 1306414000658 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 1306414000659 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 1306414000660 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1306414000661 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1306414000662 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306414000663 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306414000664 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1306414000665 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1306414000666 MaoC like domain; Region: MaoC_dehydratas; pfam01575 1306414000667 active site 2 [active] 1306414000668 active site 1 [active] 1306414000669 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 1306414000670 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1306414000671 NAD(P) binding site [chemical binding]; other site 1306414000672 active site 1306414000673 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 1306414000674 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1306414000675 dimer interface [polypeptide binding]; other site 1306414000676 active site 1306414000677 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1306414000678 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1306414000679 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 1306414000680 FAD binding site [chemical binding]; other site 1306414000681 substrate binding site [chemical binding]; other site 1306414000682 catalytic residues [active] 1306414000683 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1306414000684 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1306414000685 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 1306414000686 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1306414000687 catalytic loop [active] 1306414000688 iron binding site [ion binding]; other site 1306414000689 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 1306414000690 L-aspartate oxidase; Provisional; Region: PRK06175 1306414000691 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1306414000692 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1306414000693 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1306414000694 putative dimer interface [polypeptide binding]; other site 1306414000695 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 1306414000696 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1306414000697 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1306414000698 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1306414000699 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 1306414000700 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1306414000701 homotrimer interface [polypeptide binding]; other site 1306414000702 Walker A motif; other site 1306414000703 GTP binding site [chemical binding]; other site 1306414000704 Walker B motif; other site 1306414000705 cobyric acid synthase; Provisional; Region: PRK00784 1306414000706 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 1306414000707 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1306414000708 catalytic triad [active] 1306414000709 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306414000710 PPE family; Region: PPE; pfam00823 1306414000711 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1306414000712 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1306414000713 putative active site [active] 1306414000714 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1306414000715 putative active site [active] 1306414000716 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 1306414000717 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1306414000718 active site 1306414000719 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 1306414000720 DNA binding site [nucleotide binding] 1306414000721 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1306414000722 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1306414000723 Coenzyme A binding pocket [chemical binding]; other site 1306414000724 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 1306414000725 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1306414000726 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 1306414000727 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1306414000728 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1306414000729 intersubunit interface [polypeptide binding]; other site 1306414000730 5-oxoprolinase; Region: PLN02666 1306414000731 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 1306414000732 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 1306414000733 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 1306414000734 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1306414000735 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 1306414000736 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 1306414000737 nucleotide binding site [chemical binding]; other site 1306414000738 acyl-CoA synthetase; Validated; Region: PRK07788 1306414000739 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1306414000740 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1306414000741 active site 1306414000742 CoA binding site [chemical binding]; other site 1306414000743 AMP binding site [chemical binding]; other site 1306414000744 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306414000745 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1306414000746 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 1306414000747 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306414000748 FAD binding site [chemical binding]; other site 1306414000749 substrate binding site [chemical binding]; other site 1306414000750 catalytic base [active] 1306414000751 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1306414000752 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306414000753 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306414000754 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1306414000755 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1306414000756 Zn binding site [ion binding]; other site 1306414000757 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 1306414000758 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1306414000759 putative active site [active] 1306414000760 PE family; Region: PE; pfam00934 1306414000761 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306414000762 PPE family; Region: PPE; pfam00823 1306414000763 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306414000764 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1306414000765 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1306414000766 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1306414000767 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1306414000768 Walker A motif; other site 1306414000769 ATP binding site [chemical binding]; other site 1306414000770 Walker B motif; other site 1306414000771 arginine finger; other site 1306414000772 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1306414000773 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1306414000774 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1306414000775 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1306414000776 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1306414000777 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306414000778 PPE family; Region: PPE; pfam00823 1306414000779 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1306414000780 EspG family; Region: ESX-1_EspG; pfam14011 1306414000781 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1306414000782 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1306414000783 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1306414000784 active site 1306414000785 catalytic residues [active] 1306414000786 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1306414000787 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1306414000788 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 1306414000789 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 1306414000790 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306414000791 S-adenosylmethionine binding site [chemical binding]; other site 1306414000792 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4424 1306414000793 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1306414000794 Sulfatase; Region: Sulfatase; cl17466 1306414000795 hypothetical protein; Region: PHA01748 1306414000796 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1306414000797 putative active site [active] 1306414000798 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306414000799 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306414000800 light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs; Region: LPOR_like_SDR_c_like; cd09810 1306414000801 protochlorophyllide reductase; Region: PLN00015 1306414000802 putative NAD(P) binding site [chemical binding]; other site 1306414000803 active site 1306414000804 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 1306414000805 putative FMN binding site [chemical binding]; other site 1306414000806 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1306414000807 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1306414000808 active site 1306414000809 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 1306414000810 SnoaL-like domain; Region: SnoaL_4; pfam13577 1306414000811 SnoaL-like domain; Region: SnoaL_3; pfam13474 1306414000812 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 1306414000813 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1306414000814 nucleotide binding site [chemical binding]; other site 1306414000815 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]; Region: HtpG; COG0326 1306414000816 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 1306414000817 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 1306414000818 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 1306414000819 active site 1306414000820 catalytic residues [active] 1306414000821 Muconolactone delta-isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CatC1; COG4829 1306414000822 Muconolactone delta-isomerase; Region: MIase; cl01992 1306414000823 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 1306414000824 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1306414000825 putative active site [active] 1306414000826 catalytic site [active] 1306414000827 putative metal binding site [ion binding]; other site 1306414000828 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 1306414000829 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1306414000830 putative substrate binding pocket [chemical binding]; other site 1306414000831 AC domain interface; other site 1306414000832 catalytic triad [active] 1306414000833 AB domain interface; other site 1306414000834 interchain disulfide; other site 1306414000835 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1306414000836 trimer interface [polypeptide binding]; other site 1306414000837 active site 1306414000838 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1306414000839 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1306414000840 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1306414000841 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1306414000842 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 1306414000843 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1306414000844 dimerization interface [polypeptide binding]; other site 1306414000845 putative DNA binding site [nucleotide binding]; other site 1306414000846 putative Zn2+ binding site [ion binding]; other site 1306414000847 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1306414000848 active site residue [active] 1306414000849 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306414000850 S-adenosylmethionine binding site [chemical binding]; other site 1306414000851 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1306414000852 Cytochrome P450; Region: p450; cl12078 1306414000853 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1306414000854 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306414000855 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1306414000856 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1306414000857 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306414000858 S-adenosylmethionine binding site [chemical binding]; other site 1306414000859 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306414000860 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306414000861 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1306414000862 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1306414000863 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1306414000864 SnoaL-like domain; Region: SnoaL_2; pfam12680 1306414000865 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1306414000866 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1306414000867 substrate binding site; other site 1306414000868 tetramer interface; other site 1306414000869 PE family; Region: PE; pfam00934 1306414000870 aminotransferase AlaT; Validated; Region: PRK09265 1306414000871 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1306414000872 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1306414000873 homodimer interface [polypeptide binding]; other site 1306414000874 catalytic residue [active] 1306414000875 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1306414000876 4Fe-4S binding domain; Region: Fer4; pfam00037 1306414000877 Cysteine-rich domain; Region: CCG; pfam02754 1306414000878 Cysteine-rich domain; Region: CCG; pfam02754 1306414000879 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1306414000880 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1306414000881 DNA binding residues [nucleotide binding] 1306414000882 dimerization interface [polypeptide binding]; other site 1306414000883 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 1306414000884 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1306414000885 G1 box; other site 1306414000886 GTP/Mg2+ binding site [chemical binding]; other site 1306414000887 G2 box; other site 1306414000888 Switch I region; other site 1306414000889 G3 box; other site 1306414000890 Switch II region; other site 1306414000891 G4 box; other site 1306414000892 G5 box; other site 1306414000893 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 1306414000894 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1306414000895 G1 box; other site 1306414000896 GTP/Mg2+ binding site [chemical binding]; other site 1306414000897 G2 box; other site 1306414000898 Switch I region; other site 1306414000899 G3 box; other site 1306414000900 Switch II region; other site 1306414000901 Uncharacterized MobA-related protein [General function prediction only]; Region: COG2068 1306414000902 active site 1306414000903 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1306414000904 TIGR04255 family protein; Region: sporadTIGR04255 1306414000905 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1306414000906 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1306414000907 nucleotide binding site [chemical binding]; other site 1306414000908 NEF interaction site [polypeptide binding]; other site 1306414000909 SBD interface [polypeptide binding]; other site 1306414000910 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 1306414000911 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1306414000912 dimer interface [polypeptide binding]; other site 1306414000913 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1306414000914 chaperone protein DnaJ; Provisional; Region: PRK14279 1306414000915 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1306414000916 HSP70 interaction site [polypeptide binding]; other site 1306414000917 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1306414000918 Zn binding sites [ion binding]; other site 1306414000919 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1306414000920 dimer interface [polypeptide binding]; other site 1306414000921 Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279 1306414000922 DNA binding residues [nucleotide binding] 1306414000923 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1306414000924 putative dimer interface [polypeptide binding]; other site 1306414000925 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1306414000926 CoenzymeA binding site [chemical binding]; other site 1306414000927 subunit interaction site [polypeptide binding]; other site 1306414000928 PHB binding site; other site 1306414000929 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1306414000930 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1306414000931 GDP-binding site [chemical binding]; other site 1306414000932 ACT binding site; other site 1306414000933 IMP binding site; other site 1306414000934 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1306414000935 Peptidase family M50; Region: Peptidase_M50; pfam02163 1306414000936 active site 1306414000937 putative substrate binding region [chemical binding]; other site 1306414000938 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 1306414000939 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1306414000940 MgtE intracellular N domain; Region: MgtE_N; pfam03448 1306414000941 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1306414000942 Divalent cation transporter; Region: MgtE; pfam01769 1306414000943 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1306414000944 fructose-bisphosphate aldolase, class II, yeast/E. coli subtype; Region: FruBisAldo_II_A; TIGR01520 1306414000945 active site 1306414000946 intersubunit interface [polypeptide binding]; other site 1306414000947 zinc binding site [ion binding]; other site 1306414000948 Na+ binding site [ion binding]; other site 1306414000949 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1306414000950 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1306414000951 Predicted glycosyl hydrolase [Carbohydrate transport and metabolism]; Region: COG4833 1306414000952 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 1306414000953 AAA domain; Region: AAA_33; pfam13671 1306414000954 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 1306414000955 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 1306414000956 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1306414000957 metal ion-dependent adhesion site (MIDAS); other site 1306414000958 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 1306414000959 putative hydrophobic ligand binding site [chemical binding]; other site 1306414000960 MoxR-like ATPases [General function prediction only]; Region: COG0714 1306414000961 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1306414000962 Ligand binding site; other site 1306414000963 metal-binding site 1306414000964 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1306414000965 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1306414000966 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1306414000967 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 1306414000968 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 1306414000969 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1306414000970 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1306414000971 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1306414000972 catalytic loop [active] 1306414000973 iron binding site [ion binding]; other site 1306414000974 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1306414000975 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1306414000976 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 1306414000977 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1306414000978 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1306414000979 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1306414000980 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1306414000981 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1306414000982 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1306414000983 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1306414000984 dimerization interface [polypeptide binding]; other site 1306414000985 Uncharacterized conserved protein [Function unknown]; Region: COG3360 1306414000986 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1306414000987 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1306414000988 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1306414000989 active site 1306414000990 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1306414000991 Clp amino terminal domain; Region: Clp_N; pfam02861 1306414000992 Clp amino terminal domain; Region: Clp_N; pfam02861 1306414000993 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1306414000994 Walker A motif; other site 1306414000995 ATP binding site [chemical binding]; other site 1306414000996 Walker B motif; other site 1306414000997 arginine finger; other site 1306414000998 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1306414000999 Walker A motif; other site 1306414001000 ATP binding site [chemical binding]; other site 1306414001001 Walker B motif; other site 1306414001002 arginine finger; other site 1306414001003 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1306414001004 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1306414001005 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1306414001006 heme-binding site [chemical binding]; other site 1306414001007 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 1306414001008 FAD binding pocket [chemical binding]; other site 1306414001009 FAD binding motif [chemical binding]; other site 1306414001010 phosphate binding motif [ion binding]; other site 1306414001011 beta-alpha-beta structure motif; other site 1306414001012 NAD binding pocket [chemical binding]; other site 1306414001013 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1306414001014 cyclase homology domain; Region: CHD; cd07302 1306414001015 nucleotidyl binding site; other site 1306414001016 metal binding site [ion binding]; metal-binding site 1306414001017 dimer interface [polypeptide binding]; other site 1306414001018 Predicted ATPase [General function prediction only]; Region: COG3903 1306414001019 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1306414001020 Walker A motif; other site 1306414001021 ATP binding site [chemical binding]; other site 1306414001022 Walker B motif; other site 1306414001023 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1306414001024 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1306414001025 DNA binding residues [nucleotide binding] 1306414001026 Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase) [Nucleotide transport and metabolism]; Region: PurT; COG0027 1306414001027 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1306414001028 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 1306414001029 active site residue [active] 1306414001030 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 1306414001031 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1306414001032 homodimer interface [polypeptide binding]; other site 1306414001033 substrate-cofactor binding pocket; other site 1306414001034 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1306414001035 catalytic residue [active] 1306414001036 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1306414001037 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1306414001038 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1306414001039 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1306414001040 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1306414001041 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1306414001042 active site 1306414001043 PLD-like domain; Region: PLDc_2; pfam13091 1306414001044 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1306414001045 Beta-lactamase; Region: Beta-lactamase; pfam00144 1306414001046 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 1306414001047 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306414001048 FAD binding site [chemical binding]; other site 1306414001049 substrate binding pocket [chemical binding]; other site 1306414001050 catalytic base [active] 1306414001051 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 1306414001052 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1306414001053 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1306414001054 acyl-CoA synthetase; Validated; Region: PRK05850 1306414001055 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1306414001056 acyl-activating enzyme (AAE) consensus motif; other site 1306414001057 active site 1306414001058 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1306414001059 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1306414001060 active site 1306414001061 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1306414001062 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1306414001063 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1306414001064 Thioesterase; Region: PKS_TE; smart00824 1306414001065 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1306414001066 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 1306414001067 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1306414001068 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1306414001069 phosphate acetyltransferase; Reviewed; Region: PRK05632 1306414001070 DRTGG domain; Region: DRTGG; pfam07085 1306414001071 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1306414001072 propionate/acetate kinase; Provisional; Region: PRK12379 1306414001073 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1306414001074 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1306414001075 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1306414001076 active site 1306414001077 ATP binding site [chemical binding]; other site 1306414001078 substrate binding site [chemical binding]; other site 1306414001079 activation loop (A-loop); other site 1306414001080 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1306414001081 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1306414001082 substrate binding pocket [chemical binding]; other site 1306414001083 membrane-bound complex binding site; other site 1306414001084 hinge residues; other site 1306414001085 NUDIX domain; Region: NUDIX; pfam00293 1306414001086 nudix motif; other site 1306414001087 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1306414001088 thiamine phosphate binding site [chemical binding]; other site 1306414001089 active site 1306414001090 pyrophosphate binding site [ion binding]; other site 1306414001091 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1306414001092 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1306414001093 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1306414001094 thiS-thiF/thiG interaction site; other site 1306414001095 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1306414001096 ThiS interaction site; other site 1306414001097 putative active site [active] 1306414001098 tetramer interface [polypeptide binding]; other site 1306414001099 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 1306414001100 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 1306414001101 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1306414001102 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 1306414001103 PA/protease or protease-like domain interface [polypeptide binding]; other site 1306414001104 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 1306414001105 active site 1306414001106 metal binding site [ion binding]; metal-binding site 1306414001107 Predicted metalloprotease [General function prediction only]; Region: COG2321 1306414001108 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1306414001109 Zn binding site [ion binding]; other site 1306414001110 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1306414001111 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1306414001112 dimer interface [polypeptide binding]; other site 1306414001113 substrate binding site [chemical binding]; other site 1306414001114 ATP binding site [chemical binding]; other site 1306414001115 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1306414001116 ThiC-associated domain; Region: ThiC-associated; pfam13667 1306414001117 ThiC family; Region: ThiC; pfam01964 1306414001118 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1306414001119 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 1306414001120 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1306414001121 motif II; other site 1306414001122 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1306414001123 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1306414001124 putative catalytic site [active] 1306414001125 putative phosphate binding site [ion binding]; other site 1306414001126 active site 1306414001127 metal binding site A [ion binding]; metal-binding site 1306414001128 DNA binding site [nucleotide binding] 1306414001129 putative AP binding site [nucleotide binding]; other site 1306414001130 putative metal binding site B [ion binding]; other site 1306414001131 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1306414001132 active site 1306414001133 catalytic residues [active] 1306414001134 metal binding site [ion binding]; metal-binding site 1306414001135 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 1306414001136 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1306414001137 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1306414001138 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1306414001139 E-class dimer interface [polypeptide binding]; other site 1306414001140 P-class dimer interface [polypeptide binding]; other site 1306414001141 active site 1306414001142 Cu2+ binding site [ion binding]; other site 1306414001143 Zn2+ binding site [ion binding]; other site 1306414001144 carboxylate-amine ligase; Provisional; Region: PRK13517 1306414001145 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1306414001146 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 1306414001147 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 1306414001148 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 1306414001149 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1306414001150 Walker A motif; other site 1306414001151 ATP binding site [chemical binding]; other site 1306414001152 Walker B motif; other site 1306414001153 arginine finger; other site 1306414001154 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1306414001155 Walker A motif; other site 1306414001156 ATP binding site [chemical binding]; other site 1306414001157 Walker B motif; other site 1306414001158 arginine finger; other site 1306414001159 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1306414001160 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1306414001161 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 1306414001162 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1306414001163 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1306414001164 dimer interface [polypeptide binding]; other site 1306414001165 putative functional site; other site 1306414001166 putative MPT binding site; other site 1306414001167 short chain dehydrogenase; Provisional; Region: PRK06197 1306414001168 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1306414001169 putative NAD(P) binding site [chemical binding]; other site 1306414001170 active site 1306414001171 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1306414001172 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1306414001173 ring oligomerisation interface [polypeptide binding]; other site 1306414001174 ATP/Mg binding site [chemical binding]; other site 1306414001175 stacking interactions; other site 1306414001176 hinge regions; other site 1306414001177 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306414001178 PPE family; Region: PPE; pfam00823 1306414001179 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1306414001180 DinB superfamily; Region: DinB_2; pfam12867 1306414001181 putative anti-sigmaE protein; Provisional; Region: PRK13920 1306414001182 Anti-sigma-K factor rskA; Region: RskA; pfam10099 1306414001183 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 1306414001184 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1306414001185 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1306414001186 DNA binding residues [nucleotide binding] 1306414001187 Steroid 5-alpha reductase family enzyme [General function prediction only]; Region: COG3752 1306414001188 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1306414001189 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306414001190 S-adenosylmethionine binding site [chemical binding]; other site 1306414001191 Uncharacterized conserved protein [Function unknown]; Region: COG3496 1306414001192 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 1306414001193 Subunit A of Class III extradiol dioxygenases; Region: Extradiol_Dioxygenase_3A_like; cl06673 1306414001194 dimer interface [polypeptide binding]; other site 1306414001195 Transport protein; Region: actII; TIGR00833 1306414001196 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1306414001197 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306414001198 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306414001199 PPE family; Region: PPE; pfam00823 1306414001200 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306414001201 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 1306414001202 enoyl-CoA hydratase; Provisional; Region: PRK12478 1306414001203 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1306414001204 substrate binding site [chemical binding]; other site 1306414001205 oxyanion hole (OAH) forming residues; other site 1306414001206 trimer interface [polypeptide binding]; other site 1306414001207 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1306414001208 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1306414001209 NAD(P) binding site [chemical binding]; other site 1306414001210 catalytic residues [active] 1306414001211 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3564 1306414001212 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 1306414001213 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1306414001214 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1306414001215 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1306414001216 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1306414001217 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1306414001218 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1306414001219 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1306414001220 non-specific DNA binding site [nucleotide binding]; other site 1306414001221 salt bridge; other site 1306414001222 sequence-specific DNA binding site [nucleotide binding]; other site 1306414001223 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1306414001224 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1306414001225 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1306414001226 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 1306414001227 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1306414001228 active site 1306414001229 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1306414001230 active site 2 [active] 1306414001231 isocitrate lyase; Provisional; Region: PRK15063 1306414001232 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cd06556 1306414001233 oligomerization interface [polypeptide binding]; other site 1306414001234 active site 1306414001235 metal binding site [ion binding]; metal-binding site 1306414001236 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 1306414001237 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1306414001238 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1306414001239 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1306414001240 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306414001241 S-adenosylmethionine binding site [chemical binding]; other site 1306414001242 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1306414001243 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1306414001244 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306414001245 S-adenosylmethionine binding site [chemical binding]; other site 1306414001246 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306414001247 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306414001248 Predicted membrane protein [Function unknown]; Region: COG2733 1306414001249 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1306414001250 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1306414001251 non-specific DNA binding site [nucleotide binding]; other site 1306414001252 salt bridge; other site 1306414001253 sequence-specific DNA binding site [nucleotide binding]; other site 1306414001254 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 1306414001255 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 1306414001256 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1306414001257 intersubunit interface [polypeptide binding]; other site 1306414001258 active site 1306414001259 catalytic residue [active] 1306414001260 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1306414001261 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1306414001262 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 1306414001263 putative active site [active] 1306414001264 catalytic triad [active] 1306414001265 putative dimer interface [polypeptide binding]; other site 1306414001266 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 1306414001267 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 1306414001268 FAD binding domain; Region: FAD_binding_4; pfam01565 1306414001269 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1306414001270 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1306414001271 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1306414001272 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1306414001273 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1306414001274 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1306414001275 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1306414001276 NAD(P) binding site [chemical binding]; other site 1306414001277 active site 1306414001278 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1306414001279 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1306414001280 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1306414001281 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 1306414001282 putative ADP-binding pocket [chemical binding]; other site 1306414001283 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1306414001284 L-lysine exporter; Region: 2a75; TIGR00948 1306414001285 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1306414001286 catalytic core [active] 1306414001287 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1306414001288 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1306414001289 dimer interface [polypeptide binding]; other site 1306414001290 phosphorylation site [posttranslational modification] 1306414001291 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1306414001292 ATP binding site [chemical binding]; other site 1306414001293 Mg2+ binding site [ion binding]; other site 1306414001294 G-X-G motif; other site 1306414001295 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1306414001296 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1306414001297 active site 1306414001298 phosphorylation site [posttranslational modification] 1306414001299 intermolecular recognition site; other site 1306414001300 dimerization interface [polypeptide binding]; other site 1306414001301 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1306414001302 DNA binding site [nucleotide binding] 1306414001303 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 1306414001304 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1306414001305 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1306414001306 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1306414001307 DNA-binding site [nucleotide binding]; DNA binding site 1306414001308 FCD domain; Region: FCD; pfam07729 1306414001309 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1306414001310 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1306414001311 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1306414001312 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1306414001313 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1306414001314 Diacylglycerol kinase catalytic domain (presumed); Region: DAGKc; smart00046 1306414001315 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1306414001316 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1306414001317 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1306414001318 DNA binding domain, excisionase family; Region: excise; TIGR01764 1306414001319 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1306414001320 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 1306414001321 putative NAD(P) binding site [chemical binding]; other site 1306414001322 active site 1306414001323 putative substrate binding site [chemical binding]; other site 1306414001324 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1306414001325 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1306414001326 putative acyl-acceptor binding pocket; other site 1306414001327 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1306414001328 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1306414001329 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306414001330 S-adenosylmethionine binding site [chemical binding]; other site 1306414001331 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1306414001332 active site 1306414001333 catalytic site [active] 1306414001334 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1306414001335 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 1306414001336 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1306414001337 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1306414001338 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 1306414001339 glutamyl-tRNA reductase; Region: hemA; TIGR01035 1306414001340 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1306414001341 tRNA; other site 1306414001342 putative tRNA binding site [nucleotide binding]; other site 1306414001343 putative NADP binding site [chemical binding]; other site 1306414001344 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1306414001345 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1306414001346 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1306414001347 domain interfaces; other site 1306414001348 active site 1306414001349 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 1306414001350 active site 1306414001351 homodimer interface [polypeptide binding]; other site 1306414001352 SAM binding site [chemical binding]; other site 1306414001353 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1306414001354 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1306414001355 active site 1306414001356 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1306414001357 dimer interface [polypeptide binding]; other site 1306414001358 active site 1306414001359 Schiff base residues; other site 1306414001360 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1306414001361 anti sigma factor interaction site; other site 1306414001362 regulatory phosphorylation site [posttranslational modification]; other site 1306414001363 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1306414001364 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1306414001365 active site 1306414001366 catalytic triad [active] 1306414001367 oxyanion hole [active] 1306414001368 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 1306414001369 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306414001370 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1306414001371 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1306414001372 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1306414001373 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1306414001374 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1306414001375 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1306414001376 catalytic residue [active] 1306414001377 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1306414001378 catalytic core [active] 1306414001379 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1306414001380 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1306414001381 catalytic residues [active] 1306414001382 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1306414001383 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1306414001384 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 1306414001385 ResB-like family; Region: ResB; pfam05140 1306414001386 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 1306414001387 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1306414001388 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1306414001389 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 1306414001390 3-oxoacyl-(acyl-carrier-protein) synthase III; Region: fabH; TIGR00747 1306414001391 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1306414001392 dimer interface [polypeptide binding]; other site 1306414001393 active site 1306414001394 CoA binding pocket [chemical binding]; other site 1306414001395 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 1306414001396 UbiA prenyltransferase family; Region: UbiA; pfam01040 1306414001397 5'-methylthioadenosine phosphorylase; Validated; Region: PRK07823 1306414001398 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1306414001399 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1306414001400 NAD(P) binding site [chemical binding]; other site 1306414001401 active site 1306414001402 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1306414001403 Ligand binding site; other site 1306414001404 Putative Catalytic site; other site 1306414001405 DXD motif; other site 1306414001406 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3222 1306414001407 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 1306414001408 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1306414001409 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1306414001410 acyl-activating enzyme (AAE) consensus motif; other site 1306414001411 acyl-activating enzyme (AAE) consensus motif; other site 1306414001412 AMP binding site [chemical binding]; other site 1306414001413 active site 1306414001414 CoA binding site [chemical binding]; other site 1306414001415 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 1306414001416 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1306414001417 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1306414001418 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1306414001419 active site 1306414001420 short chain dehydrogenase; Provisional; Region: PRK05866 1306414001421 classical (c) SDRs; Region: SDR_c; cd05233 1306414001422 NAD(P) binding site [chemical binding]; other site 1306414001423 active site 1306414001424 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1306414001425 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1306414001426 substrate binding site [chemical binding]; other site 1306414001427 oxyanion hole (OAH) forming residues; other site 1306414001428 trimer interface [polypeptide binding]; other site 1306414001429 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1306414001430 putative active site [active] 1306414001431 homotetrameric interface [polypeptide binding]; other site 1306414001432 metal binding site [ion binding]; metal-binding site 1306414001433 Post-segregation antitoxin (ccd killing mechanism protein) encoded by the F plasmid [General function prediction only]; Region: COG5302 1306414001434 acyl-CoA synthetase; Validated; Region: PRK06188 1306414001435 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1306414001436 putative active site [active] 1306414001437 putative CoA binding site [chemical binding]; other site 1306414001438 putative AMP binding site [chemical binding]; other site 1306414001439 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1306414001440 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1306414001441 active site 1306414001442 O-succinylbenzoate synthase; Provisional; Region: PRK02901 1306414001443 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1306414001444 active site 1306414001445 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1306414001446 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1306414001447 TAP-like protein; Region: Abhydrolase_4; pfam08386 1306414001448 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1306414001449 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1306414001450 dimer interface [polypeptide binding]; other site 1306414001451 tetramer interface [polypeptide binding]; other site 1306414001452 PYR/PP interface [polypeptide binding]; other site 1306414001453 TPP binding site [chemical binding]; other site 1306414001454 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1306414001455 TPP-binding site; other site 1306414001456 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1306414001457 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1306414001458 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1306414001459 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1306414001460 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306414001461 S-adenosylmethionine binding site [chemical binding]; other site 1306414001462 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1306414001463 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1306414001464 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306414001465 S-adenosylmethionine binding site [chemical binding]; other site 1306414001466 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1306414001467 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1306414001468 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1306414001469 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1306414001470 substrate binding pocket [chemical binding]; other site 1306414001471 chain length determination region; other site 1306414001472 substrate-Mg2+ binding site; other site 1306414001473 catalytic residues [active] 1306414001474 aspartate-rich region 1; other site 1306414001475 active site lid residues [active] 1306414001476 aspartate-rich region 2; other site 1306414001477 heat shock protein HtpX; Provisional; Region: PRK03072 1306414001478 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439 1306414001479 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1306414001480 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1306414001481 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1306414001482 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1306414001483 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1306414001484 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1306414001485 O-methyltransferase; Region: Methyltransf_2; pfam00891 1306414001486 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1306414001487 Cytochrome P450; Region: p450; cl12078 1306414001488 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 1306414001489 ATP cone domain; Region: ATP-cone; pfam03477 1306414001490 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 1306414001491 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 1306414001492 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 1306414001493 active site 1306414001494 dimer interface [polypeptide binding]; other site 1306414001495 effector binding site; other site 1306414001496 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1306414001497 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1306414001498 active site 1306414001499 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1306414001500 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1306414001501 nicotinate phosphoribosyltransferase; Provisional; Region: PRK12484 1306414001502 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1306414001503 active site 1306414001504 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 1306414001505 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1306414001506 putative active site [active] 1306414001507 putative metal binding site [ion binding]; other site 1306414001508 hypothetical protein; Provisional; Region: PRK07588 1306414001509 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1306414001510 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1306414001511 dimerization interface [polypeptide binding]; other site 1306414001512 putative DNA binding site [nucleotide binding]; other site 1306414001513 putative Zn2+ binding site [ion binding]; other site 1306414001514 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1306414001515 putative hydrophobic ligand binding site [chemical binding]; other site 1306414001516 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1306414001517 TIGR03086 family protein; Region: TIGR03086 1306414001518 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1306414001519 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1306414001520 PE family; Region: PE; pfam00934 1306414001521 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451 1306414001522 Uncharacterized conserved protein [Function unknown]; Region: COG1656 1306414001523 Protein of unknown function DUF82; Region: DUF82; pfam01927 1306414001524 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1306414001525 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1306414001526 putative active site [active] 1306414001527 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 1306414001528 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 1306414001529 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 1306414001530 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1306414001531 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1306414001532 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1306414001533 DNA-binding site [nucleotide binding]; DNA binding site 1306414001534 FCD domain; Region: FCD; pfam07729 1306414001535 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1306414001536 Permease; Region: Permease; pfam02405 1306414001537 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1306414001538 Permease; Region: Permease; pfam02405 1306414001539 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1306414001540 mce related protein; Region: MCE; pfam02470 1306414001541 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1306414001542 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1306414001543 mce related protein; Region: MCE; pfam02470 1306414001544 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1306414001545 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1306414001546 mce related protein; Region: MCE; pfam02470 1306414001547 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1306414001548 mce related protein; Region: MCE; pfam02470 1306414001549 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1306414001550 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1306414001551 mce related protein; Region: MCE; pfam02470 1306414001552 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1306414001553 mce related protein; Region: MCE; pfam02470 1306414001554 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1306414001555 oligomeric interface; other site 1306414001556 putative active site [active] 1306414001557 homodimer interface [polypeptide binding]; other site 1306414001558 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1306414001559 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 1306414001560 AAA domain; Region: AAA_14; pfam13173 1306414001561 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1306414001562 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 1306414001563 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1306414001564 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1306414001565 ATP binding site [chemical binding]; other site 1306414001566 Mg2+ binding site [ion binding]; other site 1306414001567 G-X-G motif; other site 1306414001568 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1306414001569 dimerization interface [polypeptide binding]; other site 1306414001570 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1306414001571 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1306414001572 active site 1306414001573 phosphorylation site [posttranslational modification] 1306414001574 intermolecular recognition site; other site 1306414001575 dimerization interface [polypeptide binding]; other site 1306414001576 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1306414001577 DNA binding site [nucleotide binding] 1306414001578 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 1306414001579 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 1306414001580 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1306414001581 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 1306414001582 catalytic residues [active] 1306414001583 catalytic nucleophile [active] 1306414001584 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1306414001585 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1306414001586 Probable transposase; Region: OrfB_IS605; pfam01385 1306414001587 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 1306414001588 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 1306414001589 putative active site [active] 1306414001590 SEC-C motif; Region: SEC-C; pfam02810 1306414001591 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB-like; cd09875 1306414001592 putative active site [active] 1306414001593 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 1306414001594 dimer interface [polypeptide binding]; other site 1306414001595 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 1306414001596 active site 1306414001597 galactokinase; Provisional; Region: PRK00555 1306414001598 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1306414001599 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1306414001600 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 1306414001601 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 1306414001602 putative active site [active] 1306414001603 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1306414001604 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1306414001605 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1306414001606 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1306414001607 oligomeric interface; other site 1306414001608 putative active site [active] 1306414001609 homodimer interface [polypeptide binding]; other site 1306414001610 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 1306414001611 FIST N domain; Region: FIST; pfam08495 1306414001612 FIST C domain; Region: FIST_C; pfam10442 1306414001613 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 1306414001614 AAA domain; Region: AAA_30; pfam13604 1306414001615 Family description; Region: UvrD_C_2; pfam13538 1306414001616 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 1306414001617 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1306414001618 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 1306414001619 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1306414001620 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1306414001621 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1306414001622 substrate binding site [chemical binding]; other site 1306414001623 oxyanion hole (OAH) forming residues; other site 1306414001624 trimer interface [polypeptide binding]; other site 1306414001625 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1306414001626 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1306414001627 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1306414001628 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1306414001629 active site 1306414001630 catalytic site [active] 1306414001631 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 1306414001632 active site 1306414001633 catalytic site [active] 1306414001634 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1306414001635 active site 1306414001636 catalytic site [active] 1306414001637 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1306414001638 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1306414001639 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1306414001640 putative homodimer interface [polypeptide binding]; other site 1306414001641 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1306414001642 heterodimer interface [polypeptide binding]; other site 1306414001643 homodimer interface [polypeptide binding]; other site 1306414001644 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1306414001645 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1306414001646 23S rRNA interface [nucleotide binding]; other site 1306414001647 L7/L12 interface [polypeptide binding]; other site 1306414001648 putative thiostrepton binding site; other site 1306414001649 L25 interface [polypeptide binding]; other site 1306414001650 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1306414001651 mRNA/rRNA interface [nucleotide binding]; other site 1306414001652 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1306414001653 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306414001654 S-adenosylmethionine binding site [chemical binding]; other site 1306414001655 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1306414001656 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1306414001657 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306414001658 S-adenosylmethionine binding site [chemical binding]; other site 1306414001659 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1306414001660 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1306414001661 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306414001662 S-adenosylmethionine binding site [chemical binding]; other site 1306414001663 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1306414001664 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1306414001665 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306414001666 S-adenosylmethionine binding site [chemical binding]; other site 1306414001667 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1306414001668 TAP-like protein; Region: Abhydrolase_4; pfam08386 1306414001669 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1306414001670 ABC1 family; Region: ABC1; cl17513 1306414001671 N-terminal catalytic domain of class II alpha-mannosidases and similar proteins; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_like; cd10786 1306414001672 active site 1306414001673 catalytic site [active] 1306414001674 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 1306414001675 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 1306414001676 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 1306414001677 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1306414001678 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1306414001679 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1306414001680 23S rRNA interface [nucleotide binding]; other site 1306414001681 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1306414001682 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1306414001683 core dimer interface [polypeptide binding]; other site 1306414001684 peripheral dimer interface [polypeptide binding]; other site 1306414001685 L10 interface [polypeptide binding]; other site 1306414001686 L11 interface [polypeptide binding]; other site 1306414001687 putative EF-Tu interaction site [polypeptide binding]; other site 1306414001688 putative EF-G interaction site [polypeptide binding]; other site 1306414001689 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306414001690 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306414001691 WHG domain; Region: WHG; pfam13305 1306414001692 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 1306414001693 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 1306414001694 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1306414001695 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1306414001696 Walker A/P-loop; other site 1306414001697 ATP binding site [chemical binding]; other site 1306414001698 Q-loop/lid; other site 1306414001699 ABC transporter signature motif; other site 1306414001700 Walker B; other site 1306414001701 D-loop; other site 1306414001702 H-loop/switch region; other site 1306414001703 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1306414001704 CAAX protease self-immunity; Region: Abi; pfam02517 1306414001705 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1306414001706 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG1848 1306414001707 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1306414001708 Sulfatase; Region: Sulfatase; pfam00884 1306414001709 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1306414001710 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1306414001711 putative active site [active] 1306414001712 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1306414001713 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1306414001714 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1306414001715 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1306414001716 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1306414001717 RPB10 interaction site [polypeptide binding]; other site 1306414001718 RPB1 interaction site [polypeptide binding]; other site 1306414001719 RPB11 interaction site [polypeptide binding]; other site 1306414001720 RPB3 interaction site [polypeptide binding]; other site 1306414001721 RPB12 interaction site [polypeptide binding]; other site 1306414001722 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1306414001723 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1306414001724 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1306414001725 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1306414001726 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1306414001727 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1306414001728 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1306414001729 G-loop; other site 1306414001730 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1306414001731 DNA binding site [nucleotide binding] 1306414001732 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1306414001733 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; pfam04734 1306414001734 endonuclease IV; Provisional; Region: PRK01060 1306414001735 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1306414001736 AP (apurinic/apyrimidinic) site pocket; other site 1306414001737 DNA interaction; other site 1306414001738 Metal-binding active site; metal-binding site 1306414001739 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1306414001740 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 1306414001741 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 1306414001742 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1306414001743 active site 1306414001744 enoyl-CoA hydratase; Provisional; Region: PRK12478 1306414001745 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1306414001746 substrate binding site [chemical binding]; other site 1306414001747 oxyanion hole (OAH) forming residues; other site 1306414001748 trimer interface [polypeptide binding]; other site 1306414001749 Phenylacetic acid-responsive transcriptional repressor [Transcription]; Region: PaaX; COG3327 1306414001750 PaaX-like protein; Region: PaaX; pfam07848 1306414001751 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 1306414001752 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1306414001753 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1306414001754 substrate binding site [chemical binding]; other site 1306414001755 oxyanion hole (OAH) forming residues; other site 1306414001756 trimer interface [polypeptide binding]; other site 1306414001757 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1306414001758 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1306414001759 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 1306414001760 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 1306414001761 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306414001762 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306414001763 WHG domain; Region: WHG; pfam13305 1306414001764 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1306414001765 S17 interaction site [polypeptide binding]; other site 1306414001766 S8 interaction site; other site 1306414001767 16S rRNA interaction site [nucleotide binding]; other site 1306414001768 streptomycin interaction site [chemical binding]; other site 1306414001769 23S rRNA interaction site [nucleotide binding]; other site 1306414001770 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1306414001771 30S ribosomal protein S7; Validated; Region: PRK05302 1306414001772 elongation factor G; Reviewed; Region: PRK00007 1306414001773 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1306414001774 G1 box; other site 1306414001775 putative GEF interaction site [polypeptide binding]; other site 1306414001776 GTP/Mg2+ binding site [chemical binding]; other site 1306414001777 Switch I region; other site 1306414001778 G2 box; other site 1306414001779 G3 box; other site 1306414001780 Switch II region; other site 1306414001781 G4 box; other site 1306414001782 G5 box; other site 1306414001783 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1306414001784 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1306414001785 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1306414001786 elongation factor Tu; Reviewed; Region: PRK00049 1306414001787 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1306414001788 G1 box; other site 1306414001789 GEF interaction site [polypeptide binding]; other site 1306414001790 GTP/Mg2+ binding site [chemical binding]; other site 1306414001791 Switch I region; other site 1306414001792 G2 box; other site 1306414001793 G3 box; other site 1306414001794 Switch II region; other site 1306414001795 G4 box; other site 1306414001796 G5 box; other site 1306414001797 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1306414001798 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1306414001799 Antibiotic Binding Site [chemical binding]; other site 1306414001800 Short C-terminal domain; Region: SHOCT; pfam09851 1306414001801 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1306414001802 classical (c) SDRs; Region: SDR_c; cd05233 1306414001803 NAD(P) binding site [chemical binding]; other site 1306414001804 active site 1306414001805 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1306414001806 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1306414001807 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4427 1306414001808 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1306414001809 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306414001810 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 1306414001811 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 1306414001812 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1306414001813 FeS/SAM binding site; other site 1306414001814 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1306414001815 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 1306414001816 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1306414001817 phosphate binding site [ion binding]; other site 1306414001818 mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964 1306414001819 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 1306414001820 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1306414001821 Probable Catalytic site; other site 1306414001822 metal-binding site 1306414001823 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 1306414001824 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1306414001825 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1306414001826 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1306414001827 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1306414001828 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1306414001829 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1306414001830 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1306414001831 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1306414001832 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1306414001833 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1306414001834 putative translocon binding site; other site 1306414001835 protein-rRNA interface [nucleotide binding]; other site 1306414001836 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1306414001837 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1306414001838 G-X-X-G motif; other site 1306414001839 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1306414001840 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1306414001841 23S rRNA interface [nucleotide binding]; other site 1306414001842 5S rRNA interface [nucleotide binding]; other site 1306414001843 putative antibiotic binding site [chemical binding]; other site 1306414001844 L25 interface [polypeptide binding]; other site 1306414001845 L27 interface [polypeptide binding]; other site 1306414001846 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1306414001847 putative translocon interaction site; other site 1306414001848 23S rRNA interface [nucleotide binding]; other site 1306414001849 signal recognition particle (SRP54) interaction site; other site 1306414001850 L23 interface [polypeptide binding]; other site 1306414001851 trigger factor interaction site; other site 1306414001852 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1306414001853 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1306414001854 Sulfatase; Region: Sulfatase; pfam00884 1306414001855 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353 1306414001856 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1306414001857 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1306414001858 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1306414001859 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1306414001860 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1306414001861 RNA binding site [nucleotide binding]; other site 1306414001862 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1306414001863 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1306414001864 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1306414001865 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1306414001866 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1306414001867 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1306414001868 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1306414001869 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1306414001870 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1306414001871 5S rRNA interface [nucleotide binding]; other site 1306414001872 23S rRNA interface [nucleotide binding]; other site 1306414001873 L5 interface [polypeptide binding]; other site 1306414001874 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1306414001875 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1306414001876 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1306414001877 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1306414001878 23S rRNA binding site [nucleotide binding]; other site 1306414001879 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1306414001880 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 1306414001881 tandem repeat interface [polypeptide binding]; other site 1306414001882 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1306414001883 oligomer interface [polypeptide binding]; other site 1306414001884 active site residues [active] 1306414001885 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1306414001886 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1306414001887 tandem repeat interface [polypeptide binding]; other site 1306414001888 oligomer interface [polypeptide binding]; other site 1306414001889 active site residues [active] 1306414001890 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1306414001891 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1306414001892 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1306414001893 intersubunit interface [polypeptide binding]; other site 1306414001894 active site 1306414001895 Zn2+ binding site [ion binding]; other site 1306414001896 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1306414001897 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1306414001898 NAD binding site [chemical binding]; other site 1306414001899 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1306414001900 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1306414001901 nucleotide binding site [chemical binding]; other site 1306414001902 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1306414001903 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1306414001904 Coenzyme A binding pocket [chemical binding]; other site 1306414001905 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1306414001906 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1306414001907 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1306414001908 SecY translocase; Region: SecY; pfam00344 1306414001909 adenylate kinase; Reviewed; Region: adk; PRK00279 1306414001910 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1306414001911 AMP-binding site [chemical binding]; other site 1306414001912 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1306414001913 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1306414001914 active site 1306414001915 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 1306414001916 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1306414001917 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1306414001918 DNA binding residues [nucleotide binding] 1306414001919 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 1306414001920 Putative zinc-finger; Region: zf-HC2; pfam13490 1306414001921 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 1306414001922 PYR/PP interface [polypeptide binding]; other site 1306414001923 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1306414001924 MarR family; Region: MarR; pfam01047 1306414001925 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1306414001926 TIGR03086 family protein; Region: TIGR03086 1306414001927 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 1306414001928 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1306414001929 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1306414001930 Helix-turn-helix domain; Region: HTH_17; pfam12728 1306414001931 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 1306414001932 PE family; Region: PE; pfam00934 1306414001933 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1306414001934 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1306414001935 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1306414001936 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 1306414001937 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306414001938 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1306414001939 active site 1306414001940 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1306414001941 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1306414001942 tetrameric interface [polypeptide binding]; other site 1306414001943 NAD binding site [chemical binding]; other site 1306414001944 catalytic residues [active] 1306414001945 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1306414001946 catalytic core [active] 1306414001947 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306414001948 PPE family; Region: PPE; pfam00823 1306414001949 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306414001950 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306414001951 Helix-turn-helix domain; Region: HTH_28; pfam13518 1306414001952 Winged helix-turn helix; Region: HTH_29; pfam13551 1306414001953 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1306414001954 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1306414001955 active site 1306414001956 phosphorylation site [posttranslational modification] 1306414001957 intermolecular recognition site; other site 1306414001958 dimerization interface [polypeptide binding]; other site 1306414001959 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1306414001960 DNA binding site [nucleotide binding] 1306414001961 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1306414001962 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1306414001963 dimerization interface [polypeptide binding]; other site 1306414001964 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1306414001965 dimer interface [polypeptide binding]; other site 1306414001966 phosphorylation site [posttranslational modification] 1306414001967 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1306414001968 ATP binding site [chemical binding]; other site 1306414001969 Mg2+ binding site [ion binding]; other site 1306414001970 G-X-G motif; other site 1306414001971 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1306414001972 nucleotide binding site/active site [active] 1306414001973 HIT family signature motif; other site 1306414001974 catalytic residue [active] 1306414001975 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 1306414001976 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1306414001977 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1306414001978 NAD binding site [chemical binding]; other site 1306414001979 catalytic Zn binding site [ion binding]; other site 1306414001980 substrate binding site [chemical binding]; other site 1306414001981 structural Zn binding site [ion binding]; other site 1306414001982 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1306414001983 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1306414001984 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1306414001985 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1306414001986 Cytochrome P450; Region: p450; cl12078 1306414001987 short chain dehydrogenase; Provisional; Region: PRK07775 1306414001988 classical (c) SDRs; Region: SDR_c; cd05233 1306414001989 NAD(P) binding site [chemical binding]; other site 1306414001990 active site 1306414001991 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1306414001992 Cytochrome P450; Region: p450; cl12078 1306414001993 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306414001994 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306414001995 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 1306414001996 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 1306414001997 NAD binding site [chemical binding]; other site 1306414001998 catalytic residues [active] 1306414001999 short chain dehydrogenase; Provisional; Region: PRK07774 1306414002000 classical (c) SDRs; Region: SDR_c; cd05233 1306414002001 NAD(P) binding site [chemical binding]; other site 1306414002002 active site 1306414002003 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1306414002004 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 1306414002005 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1306414002006 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1306414002007 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1306414002008 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1306414002009 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1306414002010 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1306414002011 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1306414002012 Predicted esterase [General function prediction only]; Region: COG0627 1306414002013 S-formylglutathione hydrolase; Region: PLN02442 1306414002014 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1306414002015 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 1306414002016 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 1306414002017 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 1306414002018 tetramer interface [polypeptide binding]; other site 1306414002019 active site 1306414002020 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1306414002021 Cytochrome P450; Region: p450; cl12078 1306414002022 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1306414002023 ATP binding site [chemical binding]; other site 1306414002024 active site 1306414002025 substrate binding site [chemical binding]; other site 1306414002026 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1306414002027 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1306414002028 WHG domain; Region: WHG; pfam13305 1306414002029 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1306414002030 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1306414002031 putative substrate translocation pore; other site 1306414002032 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1306414002033 Predicted deacetylase [General function prediction only]; Region: COG3233 1306414002034 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 1306414002035 putative active site [active] 1306414002036 putative Zn binding site [ion binding]; other site 1306414002037 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1306414002038 FAD binding domain; Region: FAD_binding_2; pfam00890 1306414002039 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1306414002040 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1306414002041 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1306414002042 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1306414002043 putative active site [active] 1306414002044 catalytic triad [active] 1306414002045 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1306414002046 Transglutaminase/protease-like homologues; Region: TGc; smart00460 1306414002047 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1306414002048 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1306414002049 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1306414002050 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1306414002051 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1306414002052 DNA-binding site [nucleotide binding]; DNA binding site 1306414002053 UTRA domain; Region: UTRA; pfam07702 1306414002054 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1306414002055 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1306414002056 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1306414002057 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1306414002058 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1306414002059 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1306414002060 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1306414002061 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1306414002062 Uncharacterized protein, linocin/CFP29 homolog [Function unknown]; Region: COG1659 1306414002063 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 1306414002064 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 1306414002065 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 1306414002066 active site 1306414002067 metal binding site [ion binding]; metal-binding site 1306414002068 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1306414002069 active site 1306414002070 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1306414002071 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1306414002072 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1306414002073 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1306414002074 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1306414002075 dimerization interface [polypeptide binding]; other site 1306414002076 ATP binding site [chemical binding]; other site 1306414002077 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1306414002078 dimerization interface [polypeptide binding]; other site 1306414002079 ATP binding site [chemical binding]; other site 1306414002080 CAAX protease self-immunity; Region: Abi; pfam02517 1306414002081 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1306414002082 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1306414002083 hexamer interface [polypeptide binding]; other site 1306414002084 active site 1306414002085 metal binding site [ion binding]; metal-binding site 1306414002086 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 1306414002087 amidophosphoribosyltransferase; Provisional; Region: PRK07847 1306414002088 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1306414002089 active site 1306414002090 tetramer interface [polypeptide binding]; other site 1306414002091 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1306414002092 active site 1306414002093 phosphoribosylaminoimidazole synthetase; Region: purM; TIGR00878 1306414002094 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1306414002095 dimerization interface [polypeptide binding]; other site 1306414002096 putative ATP binding site [chemical binding]; other site 1306414002097 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 1306414002098 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1306414002099 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1306414002100 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1306414002101 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1306414002102 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1306414002103 catalytic residue [active] 1306414002104 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 1306414002105 heme-binding site [chemical binding]; other site 1306414002106 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 1306414002107 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1306414002108 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1306414002109 active site residue [active] 1306414002110 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1306414002111 active site residue [active] 1306414002112 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1306414002113 catalytic residues [active] 1306414002114 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1306414002115 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1306414002116 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1306414002117 DNA binding site [nucleotide binding] 1306414002118 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 1306414002119 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1306414002120 Coenzyme A binding pocket [chemical binding]; other site 1306414002121 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 1306414002122 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1306414002123 Walker A/P-loop; other site 1306414002124 ATP binding site [chemical binding]; other site 1306414002125 Q-loop/lid; other site 1306414002126 ABC transporter signature motif; other site 1306414002127 Walker B; other site 1306414002128 D-loop; other site 1306414002129 H-loop/switch region; other site 1306414002130 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1306414002131 PhoU domain; Region: PhoU; pfam01895 1306414002132 PhoU domain; Region: PhoU; pfam01895 1306414002133 cell envelope-related function transcriptional attenuator common domain; Region: lytR_cpsA_psr; TIGR00350 1306414002134 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1306414002135 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1306414002136 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1306414002137 FMN binding site [chemical binding]; other site 1306414002138 active site 1306414002139 catalytic residues [active] 1306414002140 substrate binding site [chemical binding]; other site 1306414002141 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 1306414002142 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 1306414002143 homodimer interface [polypeptide binding]; other site 1306414002144 putative substrate binding pocket [chemical binding]; other site 1306414002145 diiron center [ion binding]; other site 1306414002146 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306414002147 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 1306414002148 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1306414002149 dimerization interface [polypeptide binding]; other site 1306414002150 putative DNA binding site [nucleotide binding]; other site 1306414002151 putative Zn2+ binding site [ion binding]; other site 1306414002152 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1306414002153 dimer interface [polypeptide binding]; other site 1306414002154 catalytic motif [active] 1306414002155 nucleoside/Zn binding site; other site 1306414002156 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1306414002157 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1306414002158 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1306414002159 TIGR04255 family protein; Region: sporadTIGR04255 1306414002160 PE family; Region: PE; pfam00934 1306414002161 PE family; Region: PE; pfam00934 1306414002162 PknH-like extracellular domain; Region: PknH_C; pfam14032 1306414002163 Predicted nucleotidyltransferase [General function prediction only]; Region: COG4849 1306414002164 D-ala-D-ala dipeptidase; Region: Peptidase_M15; pfam01427 1306414002165 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306414002166 S-adenosylmethionine binding site [chemical binding]; other site 1306414002167 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 1306414002168 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1306414002169 putative substrate translocation pore; other site 1306414002170 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1306414002171 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1306414002172 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1306414002173 tetramer interface [polypeptide binding]; other site 1306414002174 TPP-binding site [chemical binding]; other site 1306414002175 heterodimer interface [polypeptide binding]; other site 1306414002176 phosphorylation loop region [posttranslational modification] 1306414002177 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1306414002178 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1306414002179 active site 1306414002180 phosphorylation site [posttranslational modification] 1306414002181 intermolecular recognition site; other site 1306414002182 dimerization interface [polypeptide binding]; other site 1306414002183 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1306414002184 DNA binding residues [nucleotide binding] 1306414002185 dimerization interface [polypeptide binding]; other site 1306414002186 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1306414002187 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1306414002188 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1306414002189 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1306414002190 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1306414002191 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1306414002192 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1306414002193 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1306414002194 dimer interface [polypeptide binding]; other site 1306414002195 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1306414002196 catalytic residue [active] 1306414002197 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1306414002198 short chain dehydrogenase; Provisional; Region: PRK05876 1306414002199 classical (c) SDRs; Region: SDR_c; cd05233 1306414002200 NAD(P) binding site [chemical binding]; other site 1306414002201 active site 1306414002202 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1306414002203 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 1306414002204 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 1306414002205 dimer interface [polypeptide binding]; other site 1306414002206 PYR/PP interface [polypeptide binding]; other site 1306414002207 TPP binding site [chemical binding]; other site 1306414002208 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1306414002209 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 1306414002210 TPP-binding site [chemical binding]; other site 1306414002211 dimer interface [polypeptide binding]; other site 1306414002212 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1306414002213 putative hydrophobic ligand binding site [chemical binding]; other site 1306414002214 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1306414002215 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1306414002216 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1306414002217 putative hydrophobic ligand binding site [chemical binding]; other site 1306414002218 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1306414002219 putative hydrophobic ligand binding site [chemical binding]; other site 1306414002220 aminotransferase; Validated; Region: PRK07777 1306414002221 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1306414002222 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1306414002223 homodimer interface [polypeptide binding]; other site 1306414002224 catalytic residue [active] 1306414002225 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 1306414002226 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1306414002227 dimer interface [polypeptide binding]; other site 1306414002228 active site 1306414002229 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 1306414002230 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1306414002231 substrate binding site [chemical binding]; other site 1306414002232 oxyanion hole (OAH) forming residues; other site 1306414002233 trimer interface [polypeptide binding]; other site 1306414002234 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1306414002235 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1306414002236 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1306414002237 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1306414002238 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1306414002239 ATP binding site [chemical binding]; other site 1306414002240 putative Mg++ binding site [ion binding]; other site 1306414002241 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1306414002242 nucleotide binding region [chemical binding]; other site 1306414002243 ATP-binding site [chemical binding]; other site 1306414002244 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1306414002245 WYL domain; Region: WYL; pfam13280 1306414002246 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1306414002247 trimer interface [polypeptide binding]; other site 1306414002248 dimer interface [polypeptide binding]; other site 1306414002249 putative active site [active] 1306414002250 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1306414002251 MPT binding site; other site 1306414002252 trimer interface [polypeptide binding]; other site 1306414002253 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1306414002254 MoaE homodimer interface [polypeptide binding]; other site 1306414002255 MoaD interaction [polypeptide binding]; other site 1306414002256 active site residues [active] 1306414002257 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1306414002258 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1306414002259 MoaE interaction surface [polypeptide binding]; other site 1306414002260 MoeB interaction surface [polypeptide binding]; other site 1306414002261 thiocarboxylated glycine; other site 1306414002262 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1306414002263 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1306414002264 FeS/SAM binding site; other site 1306414002265 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1306414002266 hypothetical protein; Provisional; Region: PRK11770 1306414002267 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1306414002268 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1306414002269 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1306414002270 DNA-binding site [nucleotide binding]; DNA binding site 1306414002271 RNA-binding motif; other site 1306414002272 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1306414002273 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306414002274 active site 1306414002275 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 1306414002276 FIST N domain; Region: FIST; pfam08495 1306414002277 FIST C domain; Region: FIST_C; pfam10442 1306414002278 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 1306414002279 H+ Antiporter protein; Region: 2A0121; TIGR00900 1306414002280 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 1306414002281 Protein of unknown function (DUF2530); Region: DUF2530; pfam10745 1306414002282 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1306414002283 MarR family; Region: MarR; pfam01047 1306414002284 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1306414002285 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1306414002286 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1306414002287 Protein of unknown function (DUF2537); Region: DUF2537; pfam10801 1306414002288 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 1306414002289 phosphoserine aminotransferase, putative; Region: serC_3; TIGR01366 1306414002290 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1306414002291 catalytic residue [active] 1306414002292 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 1306414002293 Ferredoxin [Energy production and conversion]; Region: COG1146 1306414002294 4Fe-4S binding domain; Region: Fer4; pfam00037 1306414002295 ferredoxin-NADP+ reductase; Region: PLN02852 1306414002296 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1306414002297 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 1306414002298 putative dimer interface [polypeptide binding]; other site 1306414002299 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1306414002300 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1306414002301 putative catalytic site [active] 1306414002302 putative phosphate binding site [ion binding]; other site 1306414002303 putative metal binding site [ion binding]; other site 1306414002304 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 1306414002305 dimer interface [polypeptide binding]; other site 1306414002306 Citrate synthase; Region: Citrate_synt; pfam00285 1306414002307 active site 1306414002308 citrylCoA binding site [chemical binding]; other site 1306414002309 oxalacetate/citrate binding site [chemical binding]; other site 1306414002310 coenzyme A binding site [chemical binding]; other site 1306414002311 catalytic triad [active] 1306414002312 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1306414002313 cyclase homology domain; Region: CHD; cd07302 1306414002314 dimer interface [polypeptide binding]; other site 1306414002315 nucleotidyl binding site; other site 1306414002316 metal binding site [ion binding]; metal-binding site 1306414002317 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1306414002318 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1306414002319 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1306414002320 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1306414002321 AAA ATPase domain; Region: AAA_16; pfam13191 1306414002322 Predicted ATPase [General function prediction only]; Region: COG3903 1306414002323 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1306414002324 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1306414002325 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1306414002326 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1306414002327 dimer interface [polypeptide binding]; other site 1306414002328 active site 1306414002329 citrylCoA binding site [chemical binding]; other site 1306414002330 NADH binding [chemical binding]; other site 1306414002331 cationic pore residues; other site 1306414002332 oxalacetate/citrate binding site [chemical binding]; other site 1306414002333 coenzyme A binding site [chemical binding]; other site 1306414002334 catalytic triad [active] 1306414002335 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1306414002336 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 1306414002337 BON domain; Region: BON; pfam04972 1306414002338 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1306414002339 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1306414002340 ligand binding site [chemical binding]; other site 1306414002341 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 1306414002342 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1306414002343 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1306414002344 dimerization interface [polypeptide binding]; other site 1306414002345 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1306414002346 dimer interface [polypeptide binding]; other site 1306414002347 phosphorylation site [posttranslational modification] 1306414002348 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1306414002349 Mg2+ binding site [ion binding]; other site 1306414002350 G-X-G motif; other site 1306414002351 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1306414002352 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1306414002353 active site 1306414002354 phosphorylation site [posttranslational modification] 1306414002355 intermolecular recognition site; other site 1306414002356 dimerization interface [polypeptide binding]; other site 1306414002357 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1306414002358 DNA binding site [nucleotide binding] 1306414002359 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 1306414002360 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; COG0825 1306414002361 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1306414002362 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1306414002363 substrate binding site [chemical binding]; other site 1306414002364 oxyanion hole (OAH) forming residues; other site 1306414002365 trimer interface [polypeptide binding]; other site 1306414002366 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1306414002367 Beta-lactamase; Region: Beta-lactamase; pfam00144 1306414002368 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 1306414002369 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1306414002370 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1306414002371 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1306414002372 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 1306414002373 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1306414002374 hydrophobic ligand binding site; other site 1306414002375 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1306414002376 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1306414002377 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1306414002378 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1306414002379 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 1306414002380 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 1306414002381 acetyl-CoA acetyltransferase; Provisional; Region: PRK06289 1306414002382 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1306414002383 active site 1306414002384 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306414002385 PPE family; Region: PPE; pfam00823 1306414002386 PE family; Region: PE; pfam00934 1306414002387 BCCT family transporter; Region: BCCT; pfam02028 1306414002388 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 1306414002389 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1306414002390 Coenzyme A binding pocket [chemical binding]; other site 1306414002391 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1306414002392 MULE transposase domain; Region: MULE; pfam10551 1306414002393 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1306414002394 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 1306414002395 catalytic residues [active] 1306414002396 catalytic nucleophile [active] 1306414002397 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1306414002398 Probable transposase; Region: OrfB_IS605; pfam01385 1306414002399 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1306414002400 putative active site pocket [active] 1306414002401 dimerization interface [polypeptide binding]; other site 1306414002402 putative catalytic residue [active] 1306414002403 Phage-related replication protein [General function prediction only]; Region: COG4195 1306414002404 manganese transport protein MntH; Reviewed; Region: PRK00701 1306414002405 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1306414002406 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1306414002407 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1306414002408 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1306414002409 short chain dehydrogenase; Provisional; Region: PRK07814 1306414002410 classical (c) SDRs; Region: SDR_c; cd05233 1306414002411 NAD(P) binding site [chemical binding]; other site 1306414002412 active site 1306414002413 phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975 1306414002414 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1306414002415 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1306414002416 dimer interface [polypeptide binding]; other site 1306414002417 conserved gate region; other site 1306414002418 putative PBP binding loops; other site 1306414002419 ABC-ATPase subunit interface; other site 1306414002420 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1306414002421 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1306414002422 dimer interface [polypeptide binding]; other site 1306414002423 conserved gate region; other site 1306414002424 putative PBP binding loops; other site 1306414002425 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1306414002426 ABC-ATPase subunit interface; other site 1306414002427 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1306414002428 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1306414002429 active site 1306414002430 ATP binding site [chemical binding]; other site 1306414002431 substrate binding site [chemical binding]; other site 1306414002432 activation loop (A-loop); other site 1306414002433 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1306414002434 NHL repeat; Region: NHL; pfam01436 1306414002435 NHL repeat; Region: NHL; pfam01436 1306414002436 NHL repeat; Region: NHL; pfam01436 1306414002437 NHL repeat; Region: NHL; pfam01436 1306414002438 NHL repeat; Region: NHL; pfam01436 1306414002439 PBP superfamily domain; Region: PBP_like_2; cl17296 1306414002440 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14271 1306414002441 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1306414002442 Walker A/P-loop; other site 1306414002443 ATP binding site [chemical binding]; other site 1306414002444 Q-loop/lid; other site 1306414002445 ABC transporter signature motif; other site 1306414002446 Walker B; other site 1306414002447 D-loop; other site 1306414002448 H-loop/switch region; other site 1306414002449 phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975 1306414002450 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1306414002451 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1306414002452 dimer interface [polypeptide binding]; other site 1306414002453 conserved gate region; other site 1306414002454 putative PBP binding loops; other site 1306414002455 ABC-ATPase subunit interface; other site 1306414002456 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 1306414002457 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1306414002458 putative DNA binding site [nucleotide binding]; other site 1306414002459 putative homodimer interface [polypeptide binding]; other site 1306414002460 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 1306414002461 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 1306414002462 nucleotide binding site [chemical binding]; other site 1306414002463 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 1306414002464 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1306414002465 active site 1306414002466 DNA binding site [nucleotide binding] 1306414002467 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 1306414002468 DNA binding site [nucleotide binding] 1306414002469 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1306414002470 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1306414002471 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1306414002472 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1306414002473 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1306414002474 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1306414002475 anti sigma factor interaction site; other site 1306414002476 regulatory phosphorylation site [posttranslational modification]; other site 1306414002477 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1306414002478 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1306414002479 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1306414002480 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1306414002481 short chain dehydrogenase; Provisional; Region: PRK08251 1306414002482 classical (c) SDR, subgroup 6; Region: SDR_c6; cd05350 1306414002483 putative NAD(P) binding site [chemical binding]; other site 1306414002484 active site 1306414002485 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1306414002486 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1306414002487 active site 1306414002488 dimer interface [polypeptide binding]; other site 1306414002489 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1306414002490 dimer interface [polypeptide binding]; other site 1306414002491 active site 1306414002492 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 1306414002493 hypothetical protein; Provisional; Region: PRK07857 1306414002494 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1306414002495 Part of AAA domain; Region: AAA_19; pfam13245 1306414002496 Family description; Region: UvrD_C_2; pfam13538 1306414002497 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1306414002498 Peptidase family M23; Region: Peptidase_M23; pfam01551 1306414002499 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1306414002500 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1306414002501 CoA-ligase; Region: Ligase_CoA; pfam00549 1306414002502 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1306414002503 CoA binding domain; Region: CoA_binding; smart00881 1306414002504 CoA-ligase; Region: Ligase_CoA; pfam00549 1306414002505 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1306414002506 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1306414002507 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1306414002508 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1306414002509 active site 1306414002510 substrate binding site [chemical binding]; other site 1306414002511 cosubstrate binding site; other site 1306414002512 catalytic site [active] 1306414002513 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1306414002514 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1306414002515 purine monophosphate binding site [chemical binding]; other site 1306414002516 dimer interface [polypeptide binding]; other site 1306414002517 putative catalytic residues [active] 1306414002518 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1306414002519 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1306414002520 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 1306414002521 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1306414002522 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 1306414002523 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1306414002524 metal ion-dependent adhesion site (MIDAS); other site 1306414002525 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1306414002526 homotetrameric interface [polypeptide binding]; other site 1306414002527 putative active site [active] 1306414002528 metal binding site [ion binding]; metal-binding site 1306414002529 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1306414002530 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1306414002531 Thermus thermophilus CsoR, a Cu(I)-sensing transcriptional regulator, and related domains; this domain family was previously known as part of DUF156; Region: TthCsoR-like_DUF156; cd10151 1306414002532 putative homodimer interface [polypeptide binding]; other site 1306414002533 putative homotetramer interface [polypeptide binding]; other site 1306414002534 allosteric switch controlling residues; other site 1306414002535 putative metal binding site [ion binding]; other site 1306414002536 putative homodimer-homodimer interface [polypeptide binding]; other site 1306414002537 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 1306414002538 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1306414002539 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1306414002540 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1306414002541 enoyl-CoA hydratase; Provisional; Region: PRK07827 1306414002542 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1306414002543 substrate binding site [chemical binding]; other site 1306414002544 oxyanion hole (OAH) forming residues; other site 1306414002545 trimer interface [polypeptide binding]; other site 1306414002546 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306414002547 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1306414002548 active site 1306414002549 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1306414002550 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1306414002551 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1306414002552 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1306414002553 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1306414002554 carboxyltransferase (CT) interaction site; other site 1306414002555 biotinylation site [posttranslational modification]; other site 1306414002556 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1306414002557 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1306414002558 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306414002559 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1306414002560 active site 1306414002561 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 1306414002562 PE family; Region: PE; pfam00934 1306414002563 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1306414002564 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1306414002565 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1306414002566 PE family; Region: PE; pfam00934 1306414002567 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1306414002568 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1306414002569 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1306414002570 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1306414002571 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1306414002572 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1306414002573 active site 1306414002574 phosphorylation site [posttranslational modification] 1306414002575 intermolecular recognition site; other site 1306414002576 dimerization interface [polypeptide binding]; other site 1306414002577 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1306414002578 DNA binding site [nucleotide binding] 1306414002579 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1306414002580 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1306414002581 dimerization interface [polypeptide binding]; other site 1306414002582 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1306414002583 dimer interface [polypeptide binding]; other site 1306414002584 phosphorylation site [posttranslational modification] 1306414002585 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1306414002586 ATP binding site [chemical binding]; other site 1306414002587 Mg2+ binding site [ion binding]; other site 1306414002588 G-X-G motif; other site 1306414002589 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1306414002590 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1306414002591 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1306414002592 MPT binding site; other site 1306414002593 trimer interface [polypeptide binding]; other site 1306414002594 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1306414002595 Large-conductance mechanosensitive channel, MscL; Region: MscL; pfam01741 1306414002596 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1306414002597 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1306414002598 Walker A/P-loop; other site 1306414002599 ATP binding site [chemical binding]; other site 1306414002600 Q-loop/lid; other site 1306414002601 ABC transporter signature motif; other site 1306414002602 Walker B; other site 1306414002603 D-loop; other site 1306414002604 H-loop/switch region; other site 1306414002605 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1306414002606 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1306414002607 FtsX-like permease family; Region: FtsX; pfam02687 1306414002608 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1306414002609 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1306414002610 FtsX-like permease family; Region: FtsX; pfam02687 1306414002611 Predicted secreted hydrolase [General function prediction only]; Region: COG5621 1306414002612 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1306414002613 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1306414002614 substrate binding pocket [chemical binding]; other site 1306414002615 chain length determination region; other site 1306414002616 substrate-Mg2+ binding site; other site 1306414002617 catalytic residues [active] 1306414002618 aspartate-rich region 1; other site 1306414002619 active site lid residues [active] 1306414002620 aspartate-rich region 2; other site 1306414002621 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1306414002622 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2331 1306414002623 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 1306414002624 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1306414002625 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 1306414002626 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1306414002627 active site 1306414002628 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1306414002629 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1306414002630 dimer interface [polypeptide binding]; other site 1306414002631 putative functional site; other site 1306414002632 putative MPT binding site; other site 1306414002633 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1306414002634 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1306414002635 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306414002636 S-adenosylmethionine binding site [chemical binding]; other site 1306414002637 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1306414002638 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1306414002639 ligand binding site [chemical binding]; other site 1306414002640 flexible hinge region; other site 1306414002641 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1306414002642 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1306414002643 Coenzyme A binding pocket [chemical binding]; other site 1306414002644 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 1306414002645 arginine deiminase; Provisional; Region: PRK01388 1306414002646 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 1306414002647 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1306414002648 Predicted methyltransferases [General function prediction only]; Region: COG0313 1306414002649 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1306414002650 putative SAM binding site [chemical binding]; other site 1306414002651 putative homodimer interface [polypeptide binding]; other site 1306414002652 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 1306414002653 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 1306414002654 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 1306414002655 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1306414002656 active site 1306414002657 HIGH motif; other site 1306414002658 KMSKS motif; other site 1306414002659 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1306414002660 tRNA binding surface [nucleotide binding]; other site 1306414002661 anticodon binding site; other site 1306414002662 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1306414002663 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1306414002664 active site 1306414002665 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 1306414002666 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1306414002667 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1306414002668 G5 domain; Region: G5; pfam07501 1306414002669 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1306414002670 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1306414002671 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306414002672 S-adenosylmethionine binding site [chemical binding]; other site 1306414002673 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 1306414002674 Increased loss of mitochondrial DNA protein 1; Region: Ilm1; pfam10311 1306414002675 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1306414002676 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 1306414002677 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1306414002678 acyl-activating enzyme (AAE) consensus motif; other site 1306414002679 AMP binding site [chemical binding]; other site 1306414002680 active site 1306414002681 CoA binding site [chemical binding]; other site 1306414002682 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1306414002683 putative active site [active] 1306414002684 catalytic residue [active] 1306414002685 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1306414002686 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 1306414002687 5S rRNA interface [nucleotide binding]; other site 1306414002688 CTC domain interface [polypeptide binding]; other site 1306414002689 L16 interface [polypeptide binding]; other site 1306414002690 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 1306414002691 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1306414002692 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 1306414002693 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1306414002694 active site 1306414002695 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 1306414002696 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1306414002697 Substrate binding site; other site 1306414002698 Mg++ binding site; other site 1306414002699 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1306414002700 active site 1306414002701 substrate binding site [chemical binding]; other site 1306414002702 CoA binding site [chemical binding]; other site 1306414002703 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306414002704 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306414002705 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1306414002706 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1306414002707 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1306414002708 ATP binding site [chemical binding]; other site 1306414002709 putative Mg++ binding site [ion binding]; other site 1306414002710 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1306414002711 nucleotide binding region [chemical binding]; other site 1306414002712 ATP-binding site [chemical binding]; other site 1306414002713 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1306414002714 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 1306414002715 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1306414002716 homodimer interface [polypeptide binding]; other site 1306414002717 metal binding site [ion binding]; metal-binding site 1306414002718 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 1306414002719 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1306414002720 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1306414002721 enolase; Provisional; Region: eno; PRK00077 1306414002722 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1306414002723 dimer interface [polypeptide binding]; other site 1306414002724 metal binding site [ion binding]; metal-binding site 1306414002725 substrate binding pocket [chemical binding]; other site 1306414002726 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1306414002727 Septum formation initiator; Region: DivIC; pfam04977 1306414002728 Uncharacterized conserved protein [Function unknown]; Region: COG1507 1306414002729 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1306414002730 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1306414002731 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 1306414002732 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1306414002733 active site 1306414002734 phosphorylation site [posttranslational modification] 1306414002735 intermolecular recognition site; other site 1306414002736 dimerization interface [polypeptide binding]; other site 1306414002737 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1306414002738 DNA binding site [nucleotide binding] 1306414002739 K+-transporting ATPase, KdpA; Region: kdpA; TIGR00680 1306414002740 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1306414002741 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1306414002742 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1306414002743 potassium-transporting ATPase subunit C; Provisional; Region: PRK14001 1306414002744 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1306414002745 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1306414002746 dimer interface [polypeptide binding]; other site 1306414002747 phosphorylation site [posttranslational modification] 1306414002748 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1306414002749 ATP binding site [chemical binding]; other site 1306414002750 Mg2+ binding site [ion binding]; other site 1306414002751 G-X-G motif; other site 1306414002752 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1306414002753 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1306414002754 active site 1306414002755 phosphorylation site [posttranslational modification] 1306414002756 intermolecular recognition site; other site 1306414002757 dimerization interface [polypeptide binding]; other site 1306414002758 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1306414002759 DNA binding site [nucleotide binding] 1306414002760 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1306414002761 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1306414002762 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1306414002763 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1306414002764 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1306414002765 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306414002766 PPE family; Region: PPE; pfam00823 1306414002767 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1306414002768 PE family; Region: PE; pfam00934 1306414002769 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1306414002770 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1306414002771 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1306414002772 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1306414002773 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1306414002774 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1306414002775 Predicted transcriptional regulator [Transcription]; Region: COG5340 1306414002776 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1306414002777 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 1306414002778 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1306414002779 MULE transposase domain; Region: MULE; pfam10551 1306414002780 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1306414002781 MarR family; Region: MarR_2; pfam12802 1306414002782 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1306414002783 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1306414002784 NAD(P) binding site [chemical binding]; other site 1306414002785 active site 1306414002786 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 1306414002787 Helix-turn-helix domain; Region: HTH_17; pfam12728 1306414002788 Domain of unknown function (DUF427); Region: DUF427; cl00998 1306414002789 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 1306414002790 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1306414002791 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1306414002792 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 1306414002793 dimer interface [polypeptide binding]; other site 1306414002794 acyl-activating enzyme (AAE) consensus motif; other site 1306414002795 putative active site [active] 1306414002796 AMP binding site [chemical binding]; other site 1306414002797 putative CoA binding site [chemical binding]; other site 1306414002798 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1306414002799 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 1306414002800 hydrophobic ligand binding site; other site 1306414002801 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 1306414002802 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1306414002803 putative active site [active] 1306414002804 putative dimer interface [polypeptide binding]; other site 1306414002805 Patatin-like phospholipase; Region: Patatin; pfam01734 1306414002806 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1306414002807 nucleophile elbow; other site 1306414002808 hypothetical protein; Provisional; Region: PRK10279 1306414002809 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 1306414002810 active site 1306414002811 nucleophile elbow; other site 1306414002812 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 1306414002813 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1306414002814 active site residue [active] 1306414002815 PE family; Region: PE; pfam00934 1306414002816 PE family; Region: PE; pfam00934 1306414002817 Predicted membrane protein [Function unknown]; Region: COG4425 1306414002818 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 1306414002819 enoyl-CoA hydratase; Provisional; Region: PRK05862 1306414002820 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1306414002821 substrate binding site [chemical binding]; other site 1306414002822 oxyanion hole (OAH) forming residues; other site 1306414002823 trimer interface [polypeptide binding]; other site 1306414002824 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1306414002825 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1306414002826 substrate binding site [chemical binding]; other site 1306414002827 oxyanion hole (OAH) forming residues; other site 1306414002828 trimer interface [polypeptide binding]; other site 1306414002829 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1306414002830 Predicted membrane protein [Function unknown]; Region: COG4760 1306414002831 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1306414002832 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1306414002833 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 1306414002834 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1306414002835 dimer interface [polypeptide binding]; other site 1306414002836 active site 1306414002837 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 1306414002838 active site 1306414002839 catalytic triad [active] 1306414002840 oxyanion hole [active] 1306414002841 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1306414002842 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1306414002843 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 1306414002844 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1306414002845 dimer interface [polypeptide binding]; other site 1306414002846 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1306414002847 catalytic residue [active] 1306414002848 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 1306414002849 RDD family; Region: RDD; pfam06271 1306414002850 cystathionine gamma-synthase; Provisional; Region: PRK07811 1306414002851 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1306414002852 homodimer interface [polypeptide binding]; other site 1306414002853 substrate-cofactor binding pocket; other site 1306414002854 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1306414002855 catalytic residue [active] 1306414002856 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1306414002857 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1306414002858 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1306414002859 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 1306414002860 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 1306414002861 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1306414002862 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 1306414002863 catalytic residues [active] 1306414002864 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 1306414002865 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1306414002866 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1306414002867 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1306414002868 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1306414002869 catalytic residue [active] 1306414002870 putative FPP diphosphate binding site; other site 1306414002871 putative FPP binding hydrophobic cleft; other site 1306414002872 dimer interface [polypeptide binding]; other site 1306414002873 putative IPP diphosphate binding site; other site 1306414002874 PE family; Region: PE; pfam00934 1306414002875 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1306414002876 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1306414002877 putative IPP diphosphate binding site; other site 1306414002878 Cellulose binding domain; Region: CBM_2; cl17741 1306414002879 Glycosyl hydrolase family 12; Region: Glyco_hydro_12; pfam01670 1306414002880 PE family; Region: PE; pfam00934 1306414002881 pantothenate kinase; Provisional; Region: PRK05439 1306414002882 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1306414002883 ATP-binding site [chemical binding]; other site 1306414002884 CoA-binding site [chemical binding]; other site 1306414002885 Mg2+-binding site [ion binding]; other site 1306414002886 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1306414002887 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1306414002888 dimer interface [polypeptide binding]; other site 1306414002889 active site 1306414002890 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1306414002891 folate binding site [chemical binding]; other site 1306414002892 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1306414002893 dinuclear metal binding motif [ion binding]; other site 1306414002894 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1306414002895 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1306414002896 putative active site [active] 1306414002897 PhoH-like protein; Region: PhoH; pfam02562 1306414002898 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1306414002899 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1306414002900 NodB motif; other site 1306414002901 active site 1306414002902 catalytic site [active] 1306414002903 metal binding site [ion binding]; metal-binding site 1306414002904 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1306414002905 Class II fumarases; Region: Fumarase_classII; cd01362 1306414002906 active site 1306414002907 tetramer interface [polypeptide binding]; other site 1306414002908 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1306414002909 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1306414002910 putative active site [active] 1306414002911 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 1306414002912 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1306414002913 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1306414002914 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1306414002915 3beta-hydroxysteroid dehydrogenases (3b-HSD)-like, extended (e) SDRs; Region: 3b-HSD-like_SDR_e; cd05241 1306414002916 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 1306414002917 putative NAD(P) binding site [chemical binding]; other site 1306414002918 active site 1306414002919 putative substrate binding site [chemical binding]; other site 1306414002920 exodeoxyribonuclease VII, small subunit; Region: xseB; TIGR01280 1306414002921 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 1306414002922 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1306414002923 generic binding surface II; other site 1306414002924 generic binding surface I; other site 1306414002925 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1306414002926 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1306414002927 Yip1 domain; Region: Yip1; pfam04893 1306414002928 GTP-binding protein YchF; Reviewed; Region: PRK09601 1306414002929 YchF GTPase; Region: YchF; cd01900 1306414002930 G1 box; other site 1306414002931 GTP/Mg2+ binding site [chemical binding]; other site 1306414002932 Switch I region; other site 1306414002933 G2 box; other site 1306414002934 Switch II region; other site 1306414002935 G3 box; other site 1306414002936 G4 box; other site 1306414002937 G5 box; other site 1306414002938 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1306414002939 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 1306414002940 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487 1306414002941 putative active site [active] 1306414002942 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1306414002943 glucose-6-phosphate 1-dehydrogenase; Region: zwf; TIGR00871 1306414002944 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1306414002945 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1306414002946 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1306414002947 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd_rel; TIGR00872 1306414002948 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1306414002949 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1306414002950 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1306414002951 pyruvate phosphate dikinase; Provisional; Region: PRK05878 1306414002952 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1306414002953 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 1306414002954 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1306414002955 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1306414002956 active site 1306414002957 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1306414002958 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1306414002959 non-specific DNA binding site [nucleotide binding]; other site 1306414002960 salt bridge; other site 1306414002961 sequence-specific DNA binding site [nucleotide binding]; other site 1306414002962 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1306414002963 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1306414002964 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1306414002965 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 1306414002966 citrate synthase; Provisional; Region: PRK14033 1306414002967 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 1306414002968 oxalacetate binding site [chemical binding]; other site 1306414002969 citrylCoA binding site [chemical binding]; other site 1306414002970 coenzyme A binding site [chemical binding]; other site 1306414002971 catalytic triad [active] 1306414002972 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 1306414002973 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1306414002974 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1306414002975 THF binding site; other site 1306414002976 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1306414002977 substrate binding site [chemical binding]; other site 1306414002978 THF binding site; other site 1306414002979 zinc-binding site [ion binding]; other site 1306414002980 PPE family; Region: PPE; pfam00823 1306414002981 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1306414002982 active site 1306414002983 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1306414002984 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 1306414002985 CAAX protease self-immunity; Region: Abi; pfam02517 1306414002986 enoyl-CoA hydratase; Provisional; Region: PRK06688 1306414002987 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 1306414002988 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1306414002989 trimer interface [polypeptide binding]; other site 1306414002990 enoyl-CoA hydratase; Provisional; Region: PRK06688 1306414002991 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1306414002992 substrate binding site [chemical binding]; other site 1306414002993 oxyanion hole (OAH) forming residues; other site 1306414002994 trimer interface [polypeptide binding]; other site 1306414002995 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1306414002996 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1306414002997 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 1306414002998 NAD binding site [chemical binding]; other site 1306414002999 homodimer interface [polypeptide binding]; other site 1306414003000 homotetramer interface [polypeptide binding]; other site 1306414003001 active site 1306414003002 MMPL family; Region: MMPL; pfam03176 1306414003003 MMPL family; Region: MMPL; pfam03176 1306414003004 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1306414003005 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1306414003006 active site 1306414003007 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1306414003008 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1306414003009 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1306414003010 NAD-dependent deacetylase; Provisional; Region: PRK00481 1306414003011 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 1306414003012 NAD+ binding site [chemical binding]; other site 1306414003013 substrate binding site [chemical binding]; other site 1306414003014 Zn binding site [ion binding]; other site 1306414003015 Predicted transcriptional regulators [Transcription]; Region: COG1725 1306414003016 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1306414003017 DNA-binding site [nucleotide binding]; DNA binding site 1306414003018 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1306414003019 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1306414003020 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 1306414003021 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1306414003022 uncharacterized HhH-GPD family protein; Region: TIGR03252 1306414003023 minor groove reading motif; other site 1306414003024 helix-hairpin-helix signature motif; other site 1306414003025 mannosyltransferase; Provisional; Region: pimE; PRK13375 1306414003026 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 1306414003027 aromatic arch; other site 1306414003028 DCoH dimer interaction site [polypeptide binding]; other site 1306414003029 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1306414003030 DCoH tetramer interaction site [polypeptide binding]; other site 1306414003031 substrate binding site [chemical binding]; other site 1306414003032 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1306414003033 active site 1306414003034 8-oxo-dGMP binding site [chemical binding]; other site 1306414003035 nudix motif; other site 1306414003036 metal binding site [ion binding]; metal-binding site 1306414003037 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1306414003038 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1306414003039 [4Fe-4S] binding site [ion binding]; other site 1306414003040 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1306414003041 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1306414003042 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1306414003043 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1306414003044 molybdopterin cofactor binding site; other site 1306414003045 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1306414003046 nitrate reductase molybdenum cofactor assembly chaperone; Region: narJ; TIGR00684 1306414003047 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 1306414003048 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1306414003049 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1306414003050 G1 box; other site 1306414003051 putative GEF interaction site [polypeptide binding]; other site 1306414003052 GTP/Mg2+ binding site [chemical binding]; other site 1306414003053 Switch I region; other site 1306414003054 G2 box; other site 1306414003055 G3 box; other site 1306414003056 Switch II region; other site 1306414003057 G4 box; other site 1306414003058 G5 box; other site 1306414003059 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1306414003060 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1306414003061 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1306414003062 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1306414003063 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1306414003064 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306414003065 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306414003066 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306414003067 PPE family; Region: PPE; pfam00823 1306414003068 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1306414003069 PE family; Region: PE; pfam00934 1306414003070 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 1306414003071 FO synthase; Reviewed; Region: fbiC; PRK09234 1306414003072 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1306414003073 FeS/SAM binding site; other site 1306414003074 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1306414003075 FeS/SAM binding site; other site 1306414003076 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1306414003077 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 1306414003078 active site 1306414003079 FMN binding site [chemical binding]; other site 1306414003080 2,4-decadienoyl-CoA binding site; other site 1306414003081 catalytic residue [active] 1306414003082 4Fe-4S cluster binding site [ion binding]; other site 1306414003083 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1306414003084 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1306414003085 Predicted transcriptional regulators [Transcription]; Region: COG1695 1306414003086 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1306414003087 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1306414003088 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 1306414003089 4Fe-4S binding domain; Region: Fer4; pfam00037 1306414003090 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 1306414003091 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1306414003092 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1306414003093 homodimer interface [polypeptide binding]; other site 1306414003094 catalytic residue [active] 1306414003095 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1306414003096 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1306414003097 active site 1306414003098 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1306414003099 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1306414003100 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1306414003101 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1306414003102 Enoylreductase; Region: PKS_ER; smart00829 1306414003103 NAD(P) binding site [chemical binding]; other site 1306414003104 KR domain; Region: KR; pfam08659 1306414003105 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1306414003106 putative NADP binding site [chemical binding]; other site 1306414003107 active site 1306414003108 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1306414003109 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1306414003110 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1306414003111 PE-PPE domain; Region: PE-PPE; pfam08237 1306414003112 acyl-CoA synthetase; Validated; Region: PRK05850 1306414003113 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1306414003114 acyl-activating enzyme (AAE) consensus motif; other site 1306414003115 active site 1306414003116 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1306414003117 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1306414003118 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 1306414003119 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 1306414003120 Glutamate binding site [chemical binding]; other site 1306414003121 NAD binding site [chemical binding]; other site 1306414003122 catalytic residues [active] 1306414003123 Proline dehydrogenase; Region: Pro_dh; pfam01619 1306414003124 RNA polymerase sigma factor SigI; Provisional; Region: sigI; PRK09635 1306414003125 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1306414003126 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1306414003127 DNA binding residues [nucleotide binding] 1306414003128 haloalkane dehalogenase; Provisional; Region: PRK03204 1306414003129 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1306414003130 catalytic site [active] 1306414003131 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1306414003132 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 1306414003133 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1306414003134 PGAP1-like protein; Region: PGAP1; pfam07819 1306414003135 acyl-CoA synthetase; Validated; Region: PRK07787 1306414003136 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1306414003137 acyl-activating enzyme (AAE) consensus motif; other site 1306414003138 AMP binding site [chemical binding]; other site 1306414003139 active site 1306414003140 CoA binding site [chemical binding]; other site 1306414003141 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1306414003142 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1306414003143 PE family; Region: PE; pfam00934 1306414003144 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306414003145 PPE family; Region: PPE; pfam00823 1306414003146 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1306414003147 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1306414003148 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1306414003149 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1306414003150 MULE transposase domain; Region: MULE; pfam10551 1306414003151 metabolite-proton symporter; Region: 2A0106; TIGR00883 1306414003152 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1306414003153 putative substrate translocation pore; other site 1306414003154 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 1306414003155 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 1306414003156 putative trimer interface [polypeptide binding]; other site 1306414003157 putative CoA binding site [chemical binding]; other site 1306414003158 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 1306414003159 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 1306414003160 metal binding site [ion binding]; metal-binding site 1306414003161 putative dimer interface [polypeptide binding]; other site 1306414003162 TIGR00730 family protein; Region: TIGR00730 1306414003163 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 1306414003164 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 1306414003165 acyl-activating enzyme (AAE) consensus motif; other site 1306414003166 putative AMP binding site [chemical binding]; other site 1306414003167 putative active site [active] 1306414003168 putative CoA binding site [chemical binding]; other site 1306414003169 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1306414003170 dihydropteroate synthase; Region: DHPS; TIGR01496 1306414003171 substrate binding pocket [chemical binding]; other site 1306414003172 dimer interface [polypeptide binding]; other site 1306414003173 inhibitor binding site; inhibition site 1306414003174 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 1306414003175 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1306414003176 DivIVA domain; Region: DivI1A_domain; TIGR03544 1306414003177 DNA-3-methyladenine glycosylase I; Region: tag; TIGR00624 1306414003178 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 1306414003179 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 1306414003180 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1306414003181 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 1306414003182 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1306414003183 ligand binding site; other site 1306414003184 oligomer interface; other site 1306414003185 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1306414003186 dimer interface [polypeptide binding]; other site 1306414003187 N-terminal domain interface [polypeptide binding]; other site 1306414003188 sulfate 1 binding site; other site 1306414003189 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 1306414003190 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1306414003191 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1306414003192 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1306414003193 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 1306414003194 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1306414003195 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1306414003196 Walker A/P-loop; other site 1306414003197 ATP binding site [chemical binding]; other site 1306414003198 Q-loop/lid; other site 1306414003199 ABC transporter signature motif; other site 1306414003200 Walker B; other site 1306414003201 D-loop; other site 1306414003202 H-loop/switch region; other site 1306414003203 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1306414003204 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306414003205 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1306414003206 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306414003207 S-adenosylmethionine binding site [chemical binding]; other site 1306414003208 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 1306414003209 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1306414003210 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1306414003211 DNA binding residues [nucleotide binding] 1306414003212 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1306414003213 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1306414003214 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1306414003215 protein binding site [polypeptide binding]; other site 1306414003216 sec-independent translocase; Provisional; Region: PRK03100 1306414003217 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1306414003218 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1306414003219 active site 1306414003220 motif I; other site 1306414003221 motif II; other site 1306414003222 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1306414003223 Predicted membrane protein [Function unknown]; Region: COG3428 1306414003224 Bacterial PH domain; Region: DUF304; pfam03703 1306414003225 Uncharacterized conserved protein [Function unknown]; Region: COG3402 1306414003226 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 1306414003227 Domain of unknown function DUF59; Region: DUF59; cl00941 1306414003228 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1306414003229 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1306414003230 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 1306414003231 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1306414003232 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1306414003233 catalytic residue [active] 1306414003234 Predicted membrane protein [Function unknown]; Region: COG4420 1306414003235 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1306414003236 MgtE intracellular N domain; Region: MgtE_N; smart00924 1306414003237 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1306414003238 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1306414003239 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1306414003240 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1306414003241 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1306414003242 dimer interface [polypeptide binding]; other site 1306414003243 conserved gate region; other site 1306414003244 putative PBP binding loops; other site 1306414003245 ABC-ATPase subunit interface; other site 1306414003246 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1306414003247 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1306414003248 dimer interface [polypeptide binding]; other site 1306414003249 conserved gate region; other site 1306414003250 ABC-ATPase subunit interface; other site 1306414003251 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1306414003252 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1306414003253 Walker A/P-loop; other site 1306414003254 ATP binding site [chemical binding]; other site 1306414003255 Q-loop/lid; other site 1306414003256 ABC transporter signature motif; other site 1306414003257 Walker B; other site 1306414003258 D-loop; other site 1306414003259 H-loop/switch region; other site 1306414003260 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1306414003261 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 1306414003262 oligomer interface [polypeptide binding]; other site 1306414003263 metal binding site [ion binding]; metal-binding site 1306414003264 metal binding site [ion binding]; metal-binding site 1306414003265 putative Cl binding site [ion binding]; other site 1306414003266 basic sphincter; other site 1306414003267 hydrophobic gate; other site 1306414003268 periplasmic entrance; other site 1306414003269 malate dehydrogenase; Provisional; Region: PRK05442 1306414003270 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 1306414003271 NAD(P) binding site [chemical binding]; other site 1306414003272 dimer interface [polypeptide binding]; other site 1306414003273 malate binding site [chemical binding]; other site 1306414003274 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1306414003275 PE family; Region: PE; pfam00934 1306414003276 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1306414003277 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1306414003278 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1306414003279 NAD(P) binding site [chemical binding]; other site 1306414003280 active site 1306414003281 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1306414003282 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 1306414003283 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 1306414003284 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1306414003285 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1306414003286 TPP-binding site [chemical binding]; other site 1306414003287 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1306414003288 dimer interface [polypeptide binding]; other site 1306414003289 PYR/PP interface [polypeptide binding]; other site 1306414003290 TPP binding site [chemical binding]; other site 1306414003291 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1306414003292 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1306414003293 putative substrate translocation pore; other site 1306414003294 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1306414003295 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 1306414003296 RNase_H superfamily; Region: RNase_H_2; pfam13482 1306414003297 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1306414003298 Part of AAA domain; Region: AAA_19; pfam13245 1306414003299 AAA domain; Region: AAA_12; pfam13087 1306414003300 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 1306414003301 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1306414003302 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1306414003303 ATP binding site [chemical binding]; other site 1306414003304 Mg++ binding site [ion binding]; other site 1306414003305 motif III; other site 1306414003306 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1306414003307 nucleotide binding region [chemical binding]; other site 1306414003308 ATP-binding site [chemical binding]; other site 1306414003309 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 1306414003310 putative RNA binding site [nucleotide binding]; other site 1306414003311 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1306414003312 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306414003313 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306414003314 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1306414003315 FAD binding domain; Region: FAD_binding_4; pfam01565 1306414003316 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1306414003317 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1306414003318 H+ Antiporter protein; Region: 2A0121; TIGR00900 1306414003319 putative substrate translocation pore; other site 1306414003320 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 1306414003321 Fe-S cluster binding site [ion binding]; other site 1306414003322 DNA binding site [nucleotide binding] 1306414003323 active site 1306414003324 hypothetical protein; Validated; Region: PRK05868 1306414003325 hypothetical protein; Provisional; Region: PRK07236 1306414003326 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1306414003327 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1306414003328 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1306414003329 HIT family signature motif; other site 1306414003330 catalytic residue [active] 1306414003331 amidase; Provisional; Region: PRK12470 1306414003332 Amidase; Region: Amidase; pfam01425 1306414003333 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1306414003334 cyclase homology domain; Region: CHD; cd07302 1306414003335 nucleotidyl binding site; other site 1306414003336 metal binding site [ion binding]; metal-binding site 1306414003337 dimer interface [polypeptide binding]; other site 1306414003338 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 1306414003339 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1306414003340 DNA binding site [nucleotide binding] 1306414003341 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1306414003342 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1306414003343 phosphopeptide binding site; other site 1306414003344 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1306414003345 putative active site [active] 1306414003346 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 1306414003347 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 1306414003348 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1306414003349 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1306414003350 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1306414003351 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1306414003352 Walker A/P-loop; other site 1306414003353 ATP binding site [chemical binding]; other site 1306414003354 Q-loop/lid; other site 1306414003355 ABC transporter signature motif; other site 1306414003356 Walker B; other site 1306414003357 D-loop; other site 1306414003358 H-loop/switch region; other site 1306414003359 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1306414003360 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1306414003361 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1306414003362 Walker A/P-loop; other site 1306414003363 ATP binding site [chemical binding]; other site 1306414003364 Q-loop/lid; other site 1306414003365 ABC transporter signature motif; other site 1306414003366 Walker B; other site 1306414003367 D-loop; other site 1306414003368 H-loop/switch region; other site 1306414003369 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1306414003370 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1306414003371 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1306414003372 catalytic core [active] 1306414003373 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1306414003374 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1306414003375 active site 1306414003376 metal binding site [ion binding]; metal-binding site 1306414003377 DNA binding site [nucleotide binding] 1306414003378 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1306414003379 Walker A/P-loop; other site 1306414003380 ATP binding site [chemical binding]; other site 1306414003381 choline dehydrogenase; Validated; Region: PRK02106 1306414003382 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1306414003383 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1306414003384 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1306414003385 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1306414003386 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 1306414003387 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1306414003388 Walker A/P-loop; other site 1306414003389 ATP binding site [chemical binding]; other site 1306414003390 Q-loop/lid; other site 1306414003391 ABC transporter signature motif; other site 1306414003392 Walker B; other site 1306414003393 D-loop; other site 1306414003394 H-loop/switch region; other site 1306414003395 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1306414003396 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1306414003397 Walker A/P-loop; other site 1306414003398 ATP binding site [chemical binding]; other site 1306414003399 Q-loop/lid; other site 1306414003400 ABC transporter signature motif; other site 1306414003401 Walker B; other site 1306414003402 D-loop; other site 1306414003403 H-loop/switch region; other site 1306414003404 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1306414003405 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1306414003406 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1306414003407 dimer interface [polypeptide binding]; other site 1306414003408 conserved gate region; other site 1306414003409 putative PBP binding loops; other site 1306414003410 ABC-ATPase subunit interface; other site 1306414003411 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 1306414003412 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1306414003413 dimer interface [polypeptide binding]; other site 1306414003414 conserved gate region; other site 1306414003415 putative PBP binding loops; other site 1306414003416 ABC-ATPase subunit interface; other site 1306414003417 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1306414003418 active site clefts [active] 1306414003419 zinc binding site [ion binding]; other site 1306414003420 dimer interface [polypeptide binding]; other site 1306414003421 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1306414003422 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1306414003423 Active Sites [active] 1306414003424 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 1306414003425 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1306414003426 CysD dimerization site [polypeptide binding]; other site 1306414003427 G1 box; other site 1306414003428 putative GEF interaction site [polypeptide binding]; other site 1306414003429 GTP/Mg2+ binding site [chemical binding]; other site 1306414003430 Switch I region; other site 1306414003431 G2 box; other site 1306414003432 G3 box; other site 1306414003433 Switch II region; other site 1306414003434 G4 box; other site 1306414003435 G5 box; other site 1306414003436 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1306414003437 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1306414003438 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1306414003439 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1306414003440 Walker A/P-loop; other site 1306414003441 ligand-binding site [chemical binding]; other site 1306414003442 ATP binding site [chemical binding]; other site 1306414003443 Rrf2 family protein; Region: rrf2_super; TIGR00738 1306414003444 Transcriptional regulator; Region: Rrf2; pfam02082 1306414003445 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1306414003446 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1306414003447 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1306414003448 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1306414003449 Putative esterase; Region: Esterase; pfam00756 1306414003450 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1306414003451 Predicted membrane protein [Function unknown]; Region: COG4325 1306414003452 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 1306414003453 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1306414003454 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1306414003455 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1306414003456 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1306414003457 active site 1306414003458 HIGH motif; other site 1306414003459 KMSK motif region; other site 1306414003460 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1306414003461 tRNA binding surface [nucleotide binding]; other site 1306414003462 anticodon binding site; other site 1306414003463 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1306414003464 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1306414003465 active site 1306414003466 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1306414003467 substrate binding site [chemical binding]; other site 1306414003468 catalytic residues [active] 1306414003469 dimer interface [polypeptide binding]; other site 1306414003470 homoserine dehydrogenase; Provisional; Region: PRK06349 1306414003471 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1306414003472 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1306414003473 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1306414003474 threonine synthase; Reviewed; Region: PRK06721 1306414003475 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1306414003476 homodimer interface [polypeptide binding]; other site 1306414003477 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1306414003478 catalytic residue [active] 1306414003479 Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083 1306414003480 transcription termination factor Rho; Provisional; Region: PRK12678 1306414003481 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1306414003482 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1306414003483 RNA binding site [nucleotide binding]; other site 1306414003484 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1306414003485 multimer interface [polypeptide binding]; other site 1306414003486 Walker A motif; other site 1306414003487 ATP binding site [chemical binding]; other site 1306414003488 Walker B motif; other site 1306414003489 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1306414003490 peptide chain release factor 1; Region: prfA; TIGR00019 1306414003491 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1306414003492 RF-1 domain; Region: RF-1; pfam00472 1306414003493 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1306414003494 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306414003495 S-adenosylmethionine binding site [chemical binding]; other site 1306414003496 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1306414003497 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1306414003498 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1306414003499 Mg++ binding site [ion binding]; other site 1306414003500 putative catalytic motif [active] 1306414003501 substrate binding site [chemical binding]; other site 1306414003502 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1306414003503 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1306414003504 F0F1 ATP synthase subunit C; Validated; Region: PRK05880 1306414003505 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1306414003506 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1306414003507 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13428 1306414003508 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1306414003509 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 1306414003510 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1306414003511 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1306414003512 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1306414003513 Walker A motif; other site 1306414003514 ATP binding site [chemical binding]; other site 1306414003515 Walker B motif; other site 1306414003516 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1306414003517 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1306414003518 core domain interface [polypeptide binding]; other site 1306414003519 delta subunit interface [polypeptide binding]; other site 1306414003520 epsilon subunit interface [polypeptide binding]; other site 1306414003521 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1306414003522 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1306414003523 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1306414003524 alpha subunit interaction interface [polypeptide binding]; other site 1306414003525 Walker A motif; other site 1306414003526 ATP binding site [chemical binding]; other site 1306414003527 Walker B motif; other site 1306414003528 inhibitor binding site; inhibition site 1306414003529 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1306414003530 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1306414003531 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1306414003532 gamma subunit interface [polypeptide binding]; other site 1306414003533 epsilon subunit interface [polypeptide binding]; other site 1306414003534 LBP interface [polypeptide binding]; other site 1306414003535 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 1306414003536 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1306414003537 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1306414003538 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 1306414003539 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1306414003540 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1306414003541 hinge; other site 1306414003542 active site 1306414003543 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 1306414003544 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1306414003545 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1306414003546 DNA binding site [nucleotide binding] 1306414003547 active site 1306414003548 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1306414003549 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1306414003550 AlkA N-terminal domain; Region: AlkA_N; pfam06029 1306414003551 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1306414003552 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1306414003553 minor groove reading motif; other site 1306414003554 helix-hairpin-helix signature motif; other site 1306414003555 substrate binding pocket [chemical binding]; other site 1306414003556 active site 1306414003557 HAMP domain; Region: HAMP; pfam00672 1306414003558 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1306414003559 cyclase homology domain; Region: CHD; cd07302 1306414003560 nucleotidyl binding site; other site 1306414003561 metal binding site [ion binding]; metal-binding site 1306414003562 dimer interface [polypeptide binding]; other site 1306414003563 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1306414003564 dimerization interface [polypeptide binding]; other site 1306414003565 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1306414003566 cyclase homology domain; Region: CHD; cd07302 1306414003567 nucleotidyl binding site; other site 1306414003568 metal binding site [ion binding]; metal-binding site 1306414003569 dimer interface [polypeptide binding]; other site 1306414003570 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1306414003571 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1306414003572 dimerization interface [polypeptide binding]; other site 1306414003573 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1306414003574 cyclase homology domain; Region: CHD; cd07302 1306414003575 nucleotidyl binding site; other site 1306414003576 metal binding site [ion binding]; metal-binding site 1306414003577 dimer interface [polypeptide binding]; other site 1306414003578 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 1306414003579 hypothetical protein; Provisional; Region: PRK03298 1306414003580 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1306414003581 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1306414003582 dimer interface [polypeptide binding]; other site 1306414003583 substrate binding site [chemical binding]; other site 1306414003584 metal binding site [ion binding]; metal-binding site 1306414003585 putative acyltransferase; Provisional; Region: PRK05790 1306414003586 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1306414003587 dimer interface [polypeptide binding]; other site 1306414003588 active site 1306414003589 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1306414003590 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1306414003591 PE family; Region: PE; pfam00934 1306414003592 glycogen branching enzyme; Provisional; Region: PRK05402 1306414003593 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1306414003594 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1306414003595 active site 1306414003596 catalytic site [active] 1306414003597 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1306414003598 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 1306414003599 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 1306414003600 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1306414003601 active site 1306414003602 homodimer interface [polypeptide binding]; other site 1306414003603 catalytic site [active] 1306414003604 acceptor binding site [chemical binding]; other site 1306414003605 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 1306414003606 putative homodimer interface [polypeptide binding]; other site 1306414003607 putative active site pocket [active] 1306414003608 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 1306414003609 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1306414003610 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1306414003611 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1306414003612 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1306414003613 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1306414003614 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1306414003615 active site 1306414003616 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1306414003617 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 1306414003618 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 1306414003619 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 1306414003620 putative active site pocket [active] 1306414003621 cleavage site 1306414003622 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 1306414003623 MPN+ (JAMM) motif; other site 1306414003624 Zinc-binding site [ion binding]; other site 1306414003625 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1306414003626 MoaE interaction surface [polypeptide binding]; other site 1306414003627 MoeB interaction surface [polypeptide binding]; other site 1306414003628 thiocarboxylated glycine; other site 1306414003629 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1306414003630 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1306414003631 dimer interface [polypeptide binding]; other site 1306414003632 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1306414003633 catalytic residue [active] 1306414003634 Rhomboid family; Region: Rhomboid; pfam01694 1306414003635 glutamate racemase; Provisional; Region: PRK00865 1306414003636 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1306414003637 ribonuclease PH; Reviewed; Region: rph; PRK00173 1306414003638 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1306414003639 hexamer interface [polypeptide binding]; other site 1306414003640 active site 1306414003641 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1306414003642 active site 1306414003643 dimerization interface [polypeptide binding]; other site 1306414003644 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1306414003645 Glucitol operon activator [Transcription]; Region: GutM; COG4578 1306414003646 acyl carrier protein; Validated; Region: PRK05883 1306414003647 long-chain-fatty-acid--[acyl-carrier-protein] ligase; Validated; Region: PRK05851 1306414003648 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1306414003649 acyl-activating enzyme (AAE) consensus motif; other site 1306414003650 active site 1306414003651 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306414003652 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1306414003653 active site 1306414003654 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1306414003655 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1306414003656 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1306414003657 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1306414003658 FAD binding pocket [chemical binding]; other site 1306414003659 FAD binding motif [chemical binding]; other site 1306414003660 phosphate binding motif [ion binding]; other site 1306414003661 NAD binding pocket [chemical binding]; other site 1306414003662 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1306414003663 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1306414003664 Walker A/P-loop; other site 1306414003665 ATP binding site [chemical binding]; other site 1306414003666 Q-loop/lid; other site 1306414003667 ABC transporter signature motif; other site 1306414003668 Walker B; other site 1306414003669 D-loop; other site 1306414003670 H-loop/switch region; other site 1306414003671 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1306414003672 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1306414003673 Walker A/P-loop; other site 1306414003674 ATP binding site [chemical binding]; other site 1306414003675 Q-loop/lid; other site 1306414003676 ABC transporter signature motif; other site 1306414003677 Walker B; other site 1306414003678 D-loop; other site 1306414003679 H-loop/switch region; other site 1306414003680 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1306414003681 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1306414003682 NAD(P) binding site [chemical binding]; other site 1306414003683 active site 1306414003684 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1306414003685 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306414003686 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1306414003687 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1306414003688 GAF domain; Region: GAF; pfam01590 1306414003689 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1306414003690 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1306414003691 metal binding site [ion binding]; metal-binding site 1306414003692 active site 1306414003693 I-site; other site 1306414003694 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1306414003695 hypothetical protein; Provisional; Region: PRK07877 1306414003696 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 1306414003697 ATP binding site [chemical binding]; other site 1306414003698 substrate interface [chemical binding]; other site 1306414003699 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1306414003700 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1306414003701 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1306414003702 cyclase homology domain; Region: CHD; cd07302 1306414003703 nucleotidyl binding site; other site 1306414003704 dimer interface [polypeptide binding]; other site 1306414003705 metal binding site [ion binding]; metal-binding site 1306414003706 AAA ATPase domain; Region: AAA_16; pfam13191 1306414003707 Predicted ATPase [General function prediction only]; Region: COG3903 1306414003708 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1306414003709 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1306414003710 DNA binding residues [nucleotide binding] 1306414003711 dimerization interface [polypeptide binding]; other site 1306414003712 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1306414003713 cyclase homology domain; Region: CHD; cd07302 1306414003714 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 1306414003715 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1306414003716 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306414003717 PPE family; Region: PPE; pfam00823 1306414003718 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1306414003719 PAS fold; Region: PAS_4; pfam08448 1306414003720 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1306414003721 putative active site [active] 1306414003722 heme pocket [chemical binding]; other site 1306414003723 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1306414003724 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1306414003725 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1306414003726 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1306414003727 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1306414003728 anti sigma factor interaction site; other site 1306414003729 regulatory phosphorylation site [posttranslational modification]; other site 1306414003730 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1306414003731 anti sigma factor interaction site; other site 1306414003732 regulatory phosphorylation site [posttranslational modification]; other site 1306414003733 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1306414003734 synthetase active site [active] 1306414003735 NTP binding site [chemical binding]; other site 1306414003736 metal binding site [ion binding]; metal-binding site 1306414003737 Beta-lactamase; Region: Beta-lactamase; pfam00144 1306414003738 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1306414003739 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 1306414003740 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; pfam00173 1306414003741 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1306414003742 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1306414003743 putative di-iron ligands [ion binding]; other site 1306414003744 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1306414003745 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1306414003746 malonyl-CoA binding site [chemical binding]; other site 1306414003747 dimer interface [polypeptide binding]; other site 1306414003748 active site 1306414003749 product binding site; other site 1306414003750 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1306414003751 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1306414003752 uncharacterized domain; Region: TIGR00702 1306414003753 YcaO-like family; Region: YcaO; pfam02624 1306414003754 Uncharacterized conserved protein [Function unknown]; Region: COG3482 1306414003755 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306414003756 S-adenosylmethionine binding site [chemical binding]; other site 1306414003757 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1306414003758 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1306414003759 active site 1306414003760 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 1306414003761 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1306414003762 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1306414003763 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1306414003764 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1306414003765 dihydroorotase; Validated; Region: pyrC; PRK09357 1306414003766 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1306414003767 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1306414003768 active site 1306414003769 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1306414003770 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1306414003771 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1306414003772 catalytic site [active] 1306414003773 subunit interface [polypeptide binding]; other site 1306414003774 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1306414003775 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1306414003776 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1306414003777 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1306414003778 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1306414003779 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1306414003780 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1306414003781 IMP binding site; other site 1306414003782 dimer interface [polypeptide binding]; other site 1306414003783 interdomain contacts; other site 1306414003784 partial ornithine binding site; other site 1306414003785 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1306414003786 active site 1306414003787 dimer interface [polypeptide binding]; other site 1306414003788 PE family; Region: PE; pfam00934 1306414003789 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306414003790 PPE family; Region: PPE; pfam00823 1306414003791 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1306414003792 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1306414003793 catalytic site [active] 1306414003794 G-X2-G-X-G-K; other site 1306414003795 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 1306414003796 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1306414003797 Flavoprotein; Region: Flavoprotein; pfam02441 1306414003798 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1306414003799 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1306414003800 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1306414003801 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1306414003802 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1306414003803 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1306414003804 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1306414003805 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1306414003806 Cytochrome P450; Region: p450; cl12078 1306414003807 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1306414003808 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1306414003809 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1306414003810 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1306414003811 oligomeric interface; other site 1306414003812 putative active site [active] 1306414003813 homodimer interface [polypeptide binding]; other site 1306414003814 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1306414003815 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1306414003816 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1306414003817 substrate binding pocket [chemical binding]; other site 1306414003818 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1306414003819 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1306414003820 substrate binding pocket [chemical binding]; other site 1306414003821 Predicted membrane protein [Function unknown]; Region: COG3714 1306414003822 primosome assembly protein PriA; Provisional; Region: PRK14873 1306414003823 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306414003824 S-adenosylmethionine binding site [chemical binding]; other site 1306414003825 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1306414003826 MarR family; Region: MarR; pfam01047 1306414003827 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306414003828 S-adenosylmethionine binding site [chemical binding]; other site 1306414003829 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1306414003830 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1306414003831 putative active site [active] 1306414003832 substrate binding site [chemical binding]; other site 1306414003833 putative cosubstrate binding site; other site 1306414003834 catalytic site [active] 1306414003835 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1306414003836 substrate binding site [chemical binding]; other site 1306414003837 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 1306414003838 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 1306414003839 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 1306414003840 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1306414003841 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1306414003842 substrate binding site [chemical binding]; other site 1306414003843 hexamer interface [polypeptide binding]; other site 1306414003844 metal binding site [ion binding]; metal-binding site 1306414003845 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1306414003846 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1306414003847 catalytic motif [active] 1306414003848 Zn binding site [ion binding]; other site 1306414003849 RibD C-terminal domain; Region: RibD_C; pfam01872 1306414003850 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1306414003851 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1306414003852 putative substrate translocation pore; other site 1306414003853 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 1306414003854 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1306414003855 Lumazine binding domain; Region: Lum_binding; pfam00677 1306414003856 Lumazine binding domain; Region: Lum_binding; pfam00677 1306414003857 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1306414003858 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1306414003859 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1306414003860 dimerization interface [polypeptide binding]; other site 1306414003861 active site 1306414003862 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1306414003863 homopentamer interface [polypeptide binding]; other site 1306414003864 active site 1306414003865 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1306414003866 PknH-like extracellular domain; Region: PknH_C; pfam14032 1306414003867 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1306414003868 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1306414003869 putative sugar binding sites [chemical binding]; other site 1306414003870 Q-X-W motif; other site 1306414003871 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1306414003872 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1306414003873 GIY-YIG motif/motif A; other site 1306414003874 active site 1306414003875 catalytic site [active] 1306414003876 putative DNA binding site [nucleotide binding]; other site 1306414003877 metal binding site [ion binding]; metal-binding site 1306414003878 UvrB/uvrC motif; Region: UVR; pfam02151 1306414003879 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1306414003880 Helix-hairpin-helix motif; Region: HHH; pfam00633 1306414003881 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 1306414003882 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1306414003883 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1306414003884 phosphate binding site [ion binding]; other site 1306414003885 putative substrate binding pocket [chemical binding]; other site 1306414003886 dimer interface [polypeptide binding]; other site 1306414003887 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1306414003888 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1306414003889 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1306414003890 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1306414003891 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1306414003892 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1306414003893 acyl-CoA synthetase; Provisional; Region: PRK13382 1306414003894 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1306414003895 acyl-activating enzyme (AAE) consensus motif; other site 1306414003896 putative AMP binding site [chemical binding]; other site 1306414003897 putative active site [active] 1306414003898 putative CoA binding site [chemical binding]; other site 1306414003899 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1306414003900 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1306414003901 putative acyl-acceptor binding pocket; other site 1306414003902 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1306414003903 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1306414003904 PE family; Region: PE; pfam00934 1306414003905 PE-PPE domain; Region: PE-PPE; pfam08237 1306414003906 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 1306414003907 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1306414003908 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1306414003909 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1306414003910 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1306414003911 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1306414003912 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1306414003913 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1306414003914 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1306414003915 Phosphoglycerate kinase; Region: PGK; pfam00162 1306414003916 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1306414003917 substrate binding site [chemical binding]; other site 1306414003918 hinge regions; other site 1306414003919 ADP binding site [chemical binding]; other site 1306414003920 catalytic site [active] 1306414003921 triosephosphate isomerase; Provisional; Region: PRK14567 1306414003922 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1306414003923 substrate binding site [chemical binding]; other site 1306414003924 dimer interface [polypeptide binding]; other site 1306414003925 catalytic triad [active] 1306414003926 SnoaL-like domain; Region: SnoaL_2; pfam12680 1306414003927 Preprotein translocase SecG subunit; Region: SecG; cl09123 1306414003928 PE family; Region: PE; pfam00934 1306414003929 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 1306414003930 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 1306414003931 molybdopterin cofactor binding site [chemical binding]; other site 1306414003932 substrate binding site [chemical binding]; other site 1306414003933 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 1306414003934 molybdopterin cofactor binding site; other site 1306414003935 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1306414003936 hydrophobic ligand binding site; other site 1306414003937 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1306414003938 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1306414003939 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1306414003940 putative active site [active] 1306414003941 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 1306414003942 Glucose-6-P dehydrogenase subunit [Carbohydrate transport and metabolism]; Region: COG3429 1306414003943 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1306414003944 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1306414003945 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1306414003946 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 1306414003947 putative active site [active] 1306414003948 transaldolase; Provisional; Region: PRK03903 1306414003949 catalytic residue [active] 1306414003950 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1306414003951 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1306414003952 TPP-binding site [chemical binding]; other site 1306414003953 dimer interface [polypeptide binding]; other site 1306414003954 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1306414003955 PYR/PP interface [polypeptide binding]; other site 1306414003956 dimer interface [polypeptide binding]; other site 1306414003957 TPP binding site [chemical binding]; other site 1306414003958 PE family; Region: PE; pfam00934 1306414003959 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1306414003960 UbiA prenyltransferase family; Region: UbiA; pfam01040 1306414003961 PE family; Region: PE; pfam00934 1306414003962 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1306414003963 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1306414003964 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1306414003965 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1306414003966 NADP binding site [chemical binding]; other site 1306414003967 dimer interface [polypeptide binding]; other site 1306414003968 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1306414003969 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1306414003970 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 1306414003971 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1306414003972 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1306414003973 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1306414003974 Walker A/P-loop; other site 1306414003975 ATP binding site [chemical binding]; other site 1306414003976 Q-loop/lid; other site 1306414003977 ABC transporter signature motif; other site 1306414003978 Walker B; other site 1306414003979 D-loop; other site 1306414003980 H-loop/switch region; other site 1306414003981 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1306414003982 Predicted transcriptional regulator [Transcription]; Region: COG2345 1306414003983 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1306414003984 putative DNA binding site [nucleotide binding]; other site 1306414003985 putative Zn2+ binding site [ion binding]; other site 1306414003986 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1306414003987 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1306414003988 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1306414003989 protein-splicing catalytic site; other site 1306414003990 thioester formation/cholesterol transfer; other site 1306414003991 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 1306414003992 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 1306414003993 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1306414003994 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1306414003995 FeS assembly protein SufD; Region: sufD; TIGR01981 1306414003996 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1306414003997 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1306414003998 Walker A/P-loop; other site 1306414003999 ATP binding site [chemical binding]; other site 1306414004000 Q-loop/lid; other site 1306414004001 ABC transporter signature motif; other site 1306414004002 Walker B; other site 1306414004003 D-loop; other site 1306414004004 H-loop/switch region; other site 1306414004005 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1306414004006 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1306414004007 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1306414004008 catalytic residue [active] 1306414004009 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1306414004010 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1306414004011 trimerization site [polypeptide binding]; other site 1306414004012 active site 1306414004013 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1306414004014 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1306414004015 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1306414004016 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1306414004017 active site 1306414004018 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1306414004019 PE family; Region: PE; pfam00934 1306414004020 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1306414004021 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1306414004022 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1306414004023 catalytic residues [active] 1306414004024 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1306414004025 catalytic residues [active] 1306414004026 enoyl-CoA hydratase; Provisional; Region: PRK05864 1306414004027 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1306414004028 substrate binding site [chemical binding]; other site 1306414004029 oxyanion hole (OAH) forming residues; other site 1306414004030 trimer interface [polypeptide binding]; other site 1306414004031 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1306414004032 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1306414004033 Walker A/P-loop; other site 1306414004034 ATP binding site [chemical binding]; other site 1306414004035 Q-loop/lid; other site 1306414004036 ABC transporter signature motif; other site 1306414004037 Walker B; other site 1306414004038 D-loop; other site 1306414004039 H-loop/switch region; other site 1306414004040 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1306414004041 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306414004042 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306414004043 aconitate hydratase; Validated; Region: PRK09277 1306414004044 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1306414004045 substrate binding site [chemical binding]; other site 1306414004046 ligand binding site [chemical binding]; other site 1306414004047 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1306414004048 substrate binding site [chemical binding]; other site 1306414004049 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1306414004050 NlpC/P60 family; Region: NLPC_P60; pfam00877 1306414004051 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1306414004052 NlpC/P60 family; Region: NLPC_P60; pfam00877 1306414004053 MoxR-like ATPases [General function prediction only]; Region: COG0714 1306414004054 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1306414004055 Walker A motif; other site 1306414004056 ATP binding site [chemical binding]; other site 1306414004057 Walker B motif; other site 1306414004058 arginine finger; other site 1306414004059 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1306414004060 Protein of unknown function DUF58; Region: DUF58; pfam01882 1306414004061 hypothetical protein; Provisional; Region: PRK13685 1306414004062 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1306414004063 metal ion-dependent adhesion site (MIDAS); other site 1306414004064 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1306414004065 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1306414004066 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1306414004067 NAD(P) binding site [chemical binding]; other site 1306414004068 homotetramer interface [polypeptide binding]; other site 1306414004069 homodimer interface [polypeptide binding]; other site 1306414004070 active site 1306414004071 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 1306414004072 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1306414004073 NAD binding site [chemical binding]; other site 1306414004074 homotetramer interface [polypeptide binding]; other site 1306414004075 homodimer interface [polypeptide binding]; other site 1306414004076 substrate binding site [chemical binding]; other site 1306414004077 active site 1306414004078 ferrochelatase; Reviewed; Region: hemH; PRK00035 1306414004079 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1306414004080 C-terminal domain interface [polypeptide binding]; other site 1306414004081 active site 1306414004082 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1306414004083 active site 1306414004084 N-terminal domain interface [polypeptide binding]; other site 1306414004085 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 1306414004086 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1306414004087 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1306414004088 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 1306414004089 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1306414004090 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1306414004091 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 1306414004092 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 1306414004093 heterodimer interface [polypeptide binding]; other site 1306414004094 substrate interaction site [chemical binding]; other site 1306414004095 Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding) [Lipid metabolism]; Region: Sbm; COG2185 1306414004096 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 1306414004097 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 1306414004098 active site 1306414004099 substrate binding site [chemical binding]; other site 1306414004100 coenzyme B12 binding site [chemical binding]; other site 1306414004101 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1306414004102 B12 binding site [chemical binding]; other site 1306414004103 cobalt ligand [ion binding]; other site 1306414004104 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1306414004105 membrane ATPase/protein kinase; Provisional; Region: PRK09435 1306414004106 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 1306414004107 Walker A; other site 1306414004108 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1306414004109 Beta-lactamase; Region: Beta-lactamase; pfam00144 1306414004110 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1306414004111 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306414004112 S-adenosylmethionine binding site [chemical binding]; other site 1306414004113 Uncharacterized conserved protein [Function unknown]; Region: COG3360 1306414004114 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1306414004115 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1306414004116 Ligand binding site; other site 1306414004117 Putative Catalytic site; other site 1306414004118 DXD motif; other site 1306414004119 Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5285 1306414004120 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 1306414004121 active site 1306414004122 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1306414004123 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1306414004124 inhibitor-cofactor binding pocket; inhibition site 1306414004125 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1306414004126 catalytic residue [active] 1306414004127 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 1306414004128 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 1306414004129 putative trimer interface [polypeptide binding]; other site 1306414004130 putative CoA binding site [chemical binding]; other site 1306414004131 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1306414004132 S-adenosylmethionine binding site [chemical binding]; other site 1306414004133 WbqC-like protein family; Region: WbqC; pfam08889 1306414004134 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1306414004135 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1306414004136 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1306414004137 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1306414004138 NADP-binding site; other site 1306414004139 homotetramer interface [polypeptide binding]; other site 1306414004140 substrate binding site [chemical binding]; other site 1306414004141 homodimer interface [polypeptide binding]; other site 1306414004142 active site 1306414004143 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 1306414004144 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 1306414004145 NADP binding site [chemical binding]; other site 1306414004146 active site 1306414004147 putative substrate binding site [chemical binding]; other site 1306414004148 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1306414004149 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 1306414004150 metal-binding site 1306414004151 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306414004152 S-adenosylmethionine binding site [chemical binding]; other site 1306414004153 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1306414004154 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1306414004155 active site 1306414004156 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1306414004157 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1306414004158 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1306414004159 active site 1306414004160 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 1306414004161 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1306414004162 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1306414004163 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1306414004164 active site 1306414004165 acyl-CoA synthetase; Validated; Region: PRK05850 1306414004166 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1306414004167 acyl-activating enzyme (AAE) consensus motif; other site 1306414004168 active site 1306414004169 Transport protein; Region: actII; TIGR00833 1306414004170 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1306414004171 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306414004172 S-adenosylmethionine binding site [chemical binding]; other site 1306414004173 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1306414004174 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1306414004175 homodimer interface [polypeptide binding]; other site 1306414004176 active site 1306414004177 TDP-binding site; other site 1306414004178 acceptor substrate-binding pocket; other site 1306414004179 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1306414004180 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1306414004181 Probable Catalytic site; other site 1306414004182 metal-binding site 1306414004183 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1306414004184 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1306414004185 homodimer interface [polypeptide binding]; other site 1306414004186 active site 1306414004187 TDP-binding site; other site 1306414004188 acceptor substrate-binding pocket; other site 1306414004189 acyl-CoA synthetase; Validated; Region: PRK05850 1306414004190 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1306414004191 acyl-activating enzyme (AAE) consensus motif; other site 1306414004192 active site 1306414004193 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1306414004194 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1306414004195 NAD(P) binding site [chemical binding]; other site 1306414004196 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1306414004197 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1306414004198 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1306414004199 CoenzymeA binding site [chemical binding]; other site 1306414004200 subunit interaction site [polypeptide binding]; other site 1306414004201 PHB binding site; other site 1306414004202 Nitronate monooxygenase; Region: NMO; pfam03060 1306414004203 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1306414004204 FMN binding site [chemical binding]; other site 1306414004205 substrate binding site [chemical binding]; other site 1306414004206 putative catalytic residue [active] 1306414004207 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306414004208 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 1306414004209 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1306414004210 HIGH motif; other site 1306414004211 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1306414004212 active site 1306414004213 KMSKS motif; other site 1306414004214 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1306414004215 tRNA binding surface [nucleotide binding]; other site 1306414004216 anticodon binding site; other site 1306414004217 DNA polymerase IV; Provisional; Region: PRK03348 1306414004218 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1306414004219 active site 1306414004220 DNA binding site [nucleotide binding] 1306414004221 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1306414004222 active site 1306414004223 homodimer interface [polypeptide binding]; other site 1306414004224 homotetramer interface [polypeptide binding]; other site 1306414004225 lipoprotein signal peptidase; Provisional; Region: PRK14764 1306414004226 lipoprotein signal peptidase; Provisional; Region: PRK14787 1306414004227 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1306414004228 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1306414004229 active site 1306414004230 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 1306414004231 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1306414004232 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 1306414004233 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1306414004234 apolar tunnel; other site 1306414004235 heme binding site [chemical binding]; other site 1306414004236 dimerization interface [polypeptide binding]; other site 1306414004237 short chain dehydrogenase; Provisional; Region: PRK05866 1306414004238 classical (c) SDRs; Region: SDR_c; cd05233 1306414004239 NAD(P) binding site [chemical binding]; other site 1306414004240 active site 1306414004241 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1306414004242 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1306414004243 NAD(P) binding site [chemical binding]; other site 1306414004244 active site 1306414004245 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1306414004246 hydrophobic ligand binding site; other site 1306414004247 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1306414004248 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1306414004249 active site 1306414004250 PHP Thumb interface [polypeptide binding]; other site 1306414004251 metal binding site [ion binding]; metal-binding site 1306414004252 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1306414004253 generic binding surface II; other site 1306414004254 generic binding surface I; other site 1306414004255 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306414004256 PPE family; Region: PPE; pfam00823 1306414004257 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306414004258 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306414004259 glycerol-3-phosphate acyltransferase; Reviewed; Region: PRK11915 1306414004260 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1306414004261 putative acyl-acceptor binding pocket; other site 1306414004262 fumarate reductase, flavoprotein subunit; Region: fum_red_Fp; TIGR01176 1306414004263 L-aspartate oxidase; Provisional; Region: PRK06175 1306414004264 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1306414004265 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 1306414004266 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1306414004267 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 1306414004268 D-subunit interface [polypeptide binding]; other site 1306414004269 Iron-sulfur protein interface; other site 1306414004270 proximal quinone binding site [chemical binding]; other site 1306414004271 distal quinone binding site [chemical binding]; other site 1306414004272 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 1306414004273 Iron-sulfur protein interface; other site 1306414004274 proximal quinone binding site [chemical binding]; other site 1306414004275 C-subunit interface; other site 1306414004276 distal quinone binding site; other site 1306414004277 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306414004278 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306414004279 MMPL family; Region: MMPL; pfam03176 1306414004280 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1306414004281 threonine dehydratase; Validated; Region: PRK08639 1306414004282 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1306414004283 tetramer interface [polypeptide binding]; other site 1306414004284 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1306414004285 catalytic residue [active] 1306414004286 C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585 1306414004287 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1306414004288 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1306414004289 putative active site [active] 1306414004290 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 1306414004291 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 1306414004292 active site 1306414004293 catalytic site [active] 1306414004294 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1306414004295 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1306414004296 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1306414004297 active site 1306414004298 catalytic site [active] 1306414004299 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1306414004300 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1306414004301 NlpC/P60 family; Region: NLPC_P60; pfam00877 1306414004302 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 1306414004303 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1306414004304 inhibitor-cofactor binding pocket; inhibition site 1306414004305 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1306414004306 catalytic residue [active] 1306414004307 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 1306414004308 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 1306414004309 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1306414004310 catalytic residue [active] 1306414004311 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1306414004312 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 1306414004313 Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653 1306414004314 Phage capsid family; Region: Phage_capsid; pfam05065 1306414004315 Phage head maturation protease [General function prediction only]; Region: COG3740 1306414004316 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: COG3747 1306414004317 Phage associated DNA primase [General function prediction only]; Region: COG3378 1306414004318 D5 N terminal like; Region: D5_N; smart00885 1306414004319 Protein of unknown function (DUF2742); Region: DUF2742; pfam10888 1306414004320 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1306414004321 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1306414004322 catalytic residues [active] 1306414004323 Recombinase; Region: Recombinase; pfam07508 1306414004324 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1306414004325 biotin synthase; Validated; Region: PRK06256 1306414004326 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1306414004327 FeS/SAM binding site; other site 1306414004328 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1306414004329 Protein of unknown function (DUF2567); Region: DUF2567; pfam10821 1306414004330 Secretory lipase; Region: LIP; pfam03583 1306414004331 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 1306414004332 nudix motif; other site 1306414004333 quinolinate synthetase; Provisional; Region: PRK09375 1306414004334 L-aspartate oxidase; Provisional; Region: PRK07804 1306414004335 L-aspartate oxidase; Provisional; Region: PRK06175 1306414004336 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1306414004337 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 1306414004338 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1306414004339 dimerization interface [polypeptide binding]; other site 1306414004340 active site 1306414004341 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306414004342 S-adenosylmethionine binding site [chemical binding]; other site 1306414004343 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 1306414004344 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 1306414004345 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1306414004346 NAD binding site [chemical binding]; other site 1306414004347 dimerization interface [polypeptide binding]; other site 1306414004348 product binding site; other site 1306414004349 substrate binding site [chemical binding]; other site 1306414004350 zinc binding site [ion binding]; other site 1306414004351 catalytic residues [active] 1306414004352 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 1306414004353 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1306414004354 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1306414004355 homodimer interface [polypeptide binding]; other site 1306414004356 catalytic residue [active] 1306414004357 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1306414004358 4-fold oligomerization interface [polypeptide binding]; other site 1306414004359 putative active site pocket [active] 1306414004360 metal binding residues [ion binding]; metal-binding site 1306414004361 3-fold/trimer interface [polypeptide binding]; other site 1306414004362 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1306414004363 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1306414004364 putative active site [active] 1306414004365 oxyanion strand; other site 1306414004366 catalytic triad [active] 1306414004367 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1306414004368 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1306414004369 catalytic residues [active] 1306414004370 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1306414004371 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1306414004372 active site 1306414004373 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1306414004374 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1306414004375 substrate binding site [chemical binding]; other site 1306414004376 glutamase interaction surface [polypeptide binding]; other site 1306414004377 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1306414004378 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 1306414004379 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1306414004380 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1306414004381 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1306414004382 catalytic triad [active] 1306414004383 anthranilate synthase component I; Provisional; Region: PRK13571 1306414004384 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1306414004385 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1306414004386 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 1306414004387 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1306414004388 active site 1306414004389 ribulose/triose binding site [chemical binding]; other site 1306414004390 phosphate binding site [ion binding]; other site 1306414004391 substrate (anthranilate) binding pocket [chemical binding]; other site 1306414004392 product (indole) binding pocket [chemical binding]; other site 1306414004393 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1306414004394 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1306414004395 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1306414004396 catalytic residue [active] 1306414004397 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1306414004398 substrate binding site [chemical binding]; other site 1306414004399 active site 1306414004400 catalytic residues [active] 1306414004401 heterodimer interface [polypeptide binding]; other site 1306414004402 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108 1306414004403 Prolipoprotein diacylglyceryltransferase [Cell envelope biogenesis, outer membrane]; Region: Lgt; COG0682 1306414004404 TM2 domain; Region: TM2; pfam05154 1306414004405 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 1306414004406 pyruvate kinase; Provisional; Region: PRK06247 1306414004407 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1306414004408 domain interfaces; other site 1306414004409 active site 1306414004410 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1306414004411 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1306414004412 active site 1306414004413 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1306414004414 catalytic triad [active] 1306414004415 dimer interface [polypeptide binding]; other site 1306414004416 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1306414004417 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1306414004418 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 1306414004419 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1306414004420 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1306414004421 Walker A/P-loop; other site 1306414004422 Walker A/P-loop; other site 1306414004423 ATP binding site [chemical binding]; other site 1306414004424 ATP binding site [chemical binding]; other site 1306414004425 Q-loop/lid; other site 1306414004426 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1306414004427 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1306414004428 Walker A/P-loop; other site 1306414004429 ATP binding site [chemical binding]; other site 1306414004430 Q-loop/lid; other site 1306414004431 ABC transporter signature motif; other site 1306414004432 Walker B; other site 1306414004433 D-loop; other site 1306414004434 H-loop/switch region; other site 1306414004435 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1306414004436 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1306414004437 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1306414004438 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1306414004439 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 1306414004440 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1306414004441 cyclase homology domain; Region: CHD; cd07302 1306414004442 nucleotidyl binding site; other site 1306414004443 metal binding site [ion binding]; metal-binding site 1306414004444 dimer interface [polypeptide binding]; other site 1306414004445 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1306414004446 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1306414004447 active site 1306414004448 phosphorylation site [posttranslational modification] 1306414004449 intermolecular recognition site; other site 1306414004450 dimerization interface [polypeptide binding]; other site 1306414004451 ANTAR domain; Region: ANTAR; pfam03861 1306414004452 lipid-transfer protein; Provisional; Region: PRK06059 1306414004453 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1306414004454 active site 1306414004455 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1306414004456 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1306414004457 DUF35 OB-fold domain; Region: DUF35; pfam01796 1306414004458 DNA polymerase I; Provisional; Region: PRK05755 1306414004459 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1306414004460 active site 1306414004461 metal binding site 1 [ion binding]; metal-binding site 1306414004462 putative 5' ssDNA interaction site; other site 1306414004463 metal binding site 3; metal-binding site 1306414004464 metal binding site 2 [ion binding]; metal-binding site 1306414004465 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1306414004466 putative DNA binding site [nucleotide binding]; other site 1306414004467 putative metal binding site [ion binding]; other site 1306414004468 3'-5' exonuclease; Region: 35EXOc; smart00474 1306414004469 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1306414004470 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1306414004471 active site 1306414004472 DNA binding site [nucleotide binding] 1306414004473 catalytic site [active] 1306414004474 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 1306414004475 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1306414004476 RNA binding site [nucleotide binding]; other site 1306414004477 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1306414004478 RNA binding site [nucleotide binding]; other site 1306414004479 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1306414004480 RNA binding site [nucleotide binding]; other site 1306414004481 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1306414004482 RNA binding site [nucleotide binding]; other site 1306414004483 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 1306414004484 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1306414004485 CoA-binding site [chemical binding]; other site 1306414004486 ATP-binding [chemical binding]; other site 1306414004487 Uncharacterized conserved protein [Function unknown]; Region: GrpB; COG2320 1306414004488 Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306 1306414004489 excinuclease ABC subunit B; Provisional; Region: PRK05298 1306414004490 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1306414004491 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1306414004492 nucleotide binding region [chemical binding]; other site 1306414004493 ATP-binding site [chemical binding]; other site 1306414004494 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1306414004495 UvrB/uvrC motif; Region: UVR; pfam02151 1306414004496 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1306414004497 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1306414004498 putative substrate translocation pore; other site 1306414004499 Predicted membrane protein [Function unknown]; Region: COG5305 1306414004500 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1306414004501 Ligand Binding Site [chemical binding]; other site 1306414004502 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1306414004503 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1306414004504 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1306414004505 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1306414004506 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1306414004507 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1306414004508 Predicted esterase [General function prediction only]; Region: COG0627 1306414004509 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 1306414004510 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1306414004511 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1306414004512 dimer interface [polypeptide binding]; other site 1306414004513 putative anticodon binding site; other site 1306414004514 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1306414004515 motif 1; other site 1306414004516 dimer interface [polypeptide binding]; other site 1306414004517 active site 1306414004518 motif 2; other site 1306414004519 motif 3; other site 1306414004520 translation initiation factor IF-3; Region: infC; TIGR00168 1306414004521 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1306414004522 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1306414004523 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1306414004524 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1306414004525 23S rRNA binding site [nucleotide binding]; other site 1306414004526 L21 binding site [polypeptide binding]; other site 1306414004527 L13 binding site [polypeptide binding]; other site 1306414004528 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1306414004529 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1306414004530 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 1306414004531 PE family; Region: PE; pfam00934 1306414004532 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1306414004533 cyclase homology domain; Region: CHD; cd07302 1306414004534 nucleotidyl binding site; other site 1306414004535 metal binding site [ion binding]; metal-binding site 1306414004536 dimer interface [polypeptide binding]; other site 1306414004537 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1306414004538 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1306414004539 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1306414004540 dimer interface [polypeptide binding]; other site 1306414004541 motif 1; other site 1306414004542 active site 1306414004543 motif 2; other site 1306414004544 motif 3; other site 1306414004545 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1306414004546 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1306414004547 putative tRNA-binding site [nucleotide binding]; other site 1306414004548 B3/4 domain; Region: B3_4; pfam03483 1306414004549 tRNA synthetase B5 domain; Region: B5; smart00874 1306414004550 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1306414004551 dimer interface [polypeptide binding]; other site 1306414004552 motif 1; other site 1306414004553 motif 3; other site 1306414004554 motif 2; other site 1306414004555 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1306414004556 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 1306414004557 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1306414004558 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1306414004559 heterotetramer interface [polypeptide binding]; other site 1306414004560 active site pocket [active] 1306414004561 cleavage site 1306414004562 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1306414004563 feedback inhibition sensing region; other site 1306414004564 homohexameric interface [polypeptide binding]; other site 1306414004565 nucleotide binding site [chemical binding]; other site 1306414004566 N-acetyl-L-glutamate binding site [chemical binding]; other site 1306414004567 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 1306414004568 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1306414004569 inhibitor-cofactor binding pocket; inhibition site 1306414004570 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1306414004571 catalytic residue [active] 1306414004572 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1306414004573 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1306414004574 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1306414004575 arginine repressor; Provisional; Region: PRK03341 1306414004576 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1306414004577 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1306414004578 argininosuccinate synthase; Provisional; Region: PRK13820 1306414004579 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1306414004580 ANP binding site [chemical binding]; other site 1306414004581 Substrate Binding Site II [chemical binding]; other site 1306414004582 Substrate Binding Site I [chemical binding]; other site 1306414004583 argininosuccinate lyase; Provisional; Region: PRK00855 1306414004584 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1306414004585 active sites [active] 1306414004586 tetramer interface [polypeptide binding]; other site 1306414004587 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1306414004588 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1306414004589 active site 1306414004590 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1306414004591 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1306414004592 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1306414004593 Enoylreductase; Region: PKS_ER; smart00829 1306414004594 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1306414004595 NAD(P) binding site [chemical binding]; other site 1306414004596 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1306414004597 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1306414004598 putative NADP binding site [chemical binding]; other site 1306414004599 active site 1306414004600 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1306414004601 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1306414004602 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1306414004603 active site 1306414004604 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1306414004605 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1306414004606 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1306414004607 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1306414004608 Enoylreductase; Region: PKS_ER; smart00829 1306414004609 NAD(P) binding site [chemical binding]; other site 1306414004610 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1306414004611 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1306414004612 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1306414004613 putative NADP binding site [chemical binding]; other site 1306414004614 active site 1306414004615 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1306414004616 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1306414004617 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1306414004618 active site 1306414004619 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1306414004620 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1306414004621 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1306414004622 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1306414004623 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1306414004624 malonyl-CoA binding site [chemical binding]; other site 1306414004625 dimer interface [polypeptide binding]; other site 1306414004626 active site 1306414004627 product binding site; other site 1306414004628 Cytochrome P450; Region: p450; cl12078 1306414004629 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1306414004630 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 1306414004631 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1306414004632 putative substrate translocation pore; other site 1306414004633 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1306414004634 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1306414004635 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1306414004636 dimerization interface [polypeptide binding]; other site 1306414004637 putative DNA binding site [nucleotide binding]; other site 1306414004638 putative Zn2+ binding site [ion binding]; other site 1306414004639 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1306414004640 active site residue [active] 1306414004641 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1306414004642 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1306414004643 ligand binding site [chemical binding]; other site 1306414004644 flexible hinge region; other site 1306414004645 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1306414004646 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 1306414004647 putative catalytic residues [active] 1306414004648 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 1306414004649 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1306414004650 catalytic residues [active] 1306414004651 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306414004652 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1306414004653 active site 1306414004654 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 1306414004655 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1306414004656 substrate binding pocket [chemical binding]; other site 1306414004657 membrane-bound complex binding site; other site 1306414004658 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 1306414004659 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1306414004660 FeS/SAM binding site; other site 1306414004661 DivIVA protein; Region: DivIVA; pfam05103 1306414004662 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1306414004663 acyl-CoA synthetase; Validated; Region: PRK07868 1306414004664 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 1306414004665 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1306414004666 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1306414004667 acyl-activating enzyme (AAE) consensus motif; other site 1306414004668 AMP binding site [chemical binding]; other site 1306414004669 active site 1306414004670 CoA binding site [chemical binding]; other site 1306414004671 Uncharacterized conserved protein [Function unknown]; Region: COG2835 1306414004672 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306414004673 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306414004674 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 1306414004675 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1306414004676 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1306414004677 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 1306414004678 Walker A/P-loop; other site 1306414004679 ATP binding site [chemical binding]; other site 1306414004680 Q-loop/lid; other site 1306414004681 ABC transporter signature motif; other site 1306414004682 Walker B; other site 1306414004683 D-loop; other site 1306414004684 H-loop/switch region; other site 1306414004685 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1306414004686 active site 1306414004687 DNA binding site [nucleotide binding] 1306414004688 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1306414004689 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1306414004690 active site 1306414004691 HIGH motif; other site 1306414004692 dimer interface [polypeptide binding]; other site 1306414004693 KMSKS motif; other site 1306414004694 S4 RNA-binding domain; Region: S4; smart00363 1306414004695 RNA binding surface [nucleotide binding]; other site 1306414004696 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1306414004697 Tetratrico peptide repeat; Region: TPR_5; pfam12688 1306414004698 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1306414004699 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 1306414004700 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1306414004701 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1306414004702 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1306414004703 RNA binding surface [nucleotide binding]; other site 1306414004704 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306414004705 S-adenosylmethionine binding site [chemical binding]; other site 1306414004706 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 1306414004707 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1306414004708 DNA repair protein RecN; Region: recN; TIGR00634 1306414004709 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1306414004710 Walker A/P-loop; other site 1306414004711 ATP binding site [chemical binding]; other site 1306414004712 Q-loop/lid; other site 1306414004713 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1306414004714 ABC transporter signature motif; other site 1306414004715 Walker B; other site 1306414004716 D-loop; other site 1306414004717 H-loop/switch region; other site 1306414004718 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 1306414004719 Thiamine pyrophosphokinase; Region: TPK; cl08415 1306414004720 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 1306414004721 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 1306414004722 CTP synthetase; Validated; Region: pyrG; PRK05380 1306414004723 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1306414004724 Catalytic site [active] 1306414004725 active site 1306414004726 UTP binding site [chemical binding]; other site 1306414004727 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1306414004728 active site 1306414004729 putative oxyanion hole; other site 1306414004730 catalytic triad [active] 1306414004731 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1306414004732 dimer interface [polypeptide binding]; other site 1306414004733 ADP-ribose binding site [chemical binding]; other site 1306414004734 active site 1306414004735 nudix motif; other site 1306414004736 metal binding site [ion binding]; metal-binding site 1306414004737 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1306414004738 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1306414004739 active site 1306414004740 DNA binding site [nucleotide binding] 1306414004741 Int/Topo IB signature motif; other site 1306414004742 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1306414004743 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1306414004744 active site 1306414004745 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1306414004746 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306414004747 S-adenosylmethionine binding site [chemical binding]; other site 1306414004748 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 1306414004749 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306414004750 PPE family; Region: PPE; pfam00823 1306414004751 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1306414004752 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306414004753 PPE family; Region: PPE; pfam00823 1306414004754 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1306414004755 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1306414004756 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1306414004757 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1306414004758 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1306414004759 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1306414004760 P-loop; other site 1306414004761 Magnesium ion binding site [ion binding]; other site 1306414004762 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1306414004763 Magnesium ion binding site [ion binding]; other site 1306414004764 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 1306414004765 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 1306414004766 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1306414004767 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1306414004768 RNA binding surface [nucleotide binding]; other site 1306414004769 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1306414004770 active site 1306414004771 cytidylate kinase; Provisional; Region: cmk; PRK00023 1306414004772 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1306414004773 CMP-binding site; other site 1306414004774 The sites determining sugar specificity; other site 1306414004775 GTP-binding protein Der; Reviewed; Region: PRK03003 1306414004776 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1306414004777 GTP/Mg2+ binding site [chemical binding]; other site 1306414004778 Switch I region; other site 1306414004779 G2 box; other site 1306414004780 Switch II region; other site 1306414004781 G3 box; other site 1306414004782 G4 box; other site 1306414004783 G5 box; other site 1306414004784 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1306414004785 G1 box; other site 1306414004786 GTP/Mg2+ binding site [chemical binding]; other site 1306414004787 Switch I region; other site 1306414004788 G2 box; other site 1306414004789 G3 box; other site 1306414004790 Switch II region; other site 1306414004791 G4 box; other site 1306414004792 G5 box; other site 1306414004793 short chain dehydrogenase; Provisional; Region: PRK07060 1306414004794 classical (c) SDRs; Region: SDR_c; cd05233 1306414004795 NAD(P) binding site [chemical binding]; other site 1306414004796 active site 1306414004797 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1306414004798 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1306414004799 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1306414004800 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1306414004801 Cupin domain; Region: Cupin_2; pfam07883 1306414004802 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 1306414004803 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1306414004804 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1306414004805 putative switch regulator; other site 1306414004806 non-specific DNA interactions [nucleotide binding]; other site 1306414004807 DNA binding site [nucleotide binding] 1306414004808 sequence specific DNA binding site [nucleotide binding]; other site 1306414004809 putative cAMP binding site [chemical binding]; other site 1306414004810 Bacterial transcriptional regulator; Region: IclR; pfam01614 1306414004811 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1306414004812 putative active site [active] 1306414004813 homotetrameric interface [polypeptide binding]; other site 1306414004814 metal binding site [ion binding]; metal-binding site 1306414004815 biotin carboxylase-like protein; Validated; Region: PRK06524 1306414004816 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1306414004817 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1306414004818 Beta-lactamase; Region: Beta-lactamase; pfam00144 1306414004819 Predicted transcriptional regulators [Transcription]; Region: COG1733 1306414004820 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1306414004821 dimerization interface [polypeptide binding]; other site 1306414004822 putative DNA binding site [nucleotide binding]; other site 1306414004823 putative Zn2+ binding site [ion binding]; other site 1306414004824 Predicted transcriptional regulators [Transcription]; Region: COG1733 1306414004825 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1306414004826 FAD binding domain; Region: FAD_binding_4; pfam01565 1306414004827 Berberine and berberine like; Region: BBE; pfam08031 1306414004828 TIGR03086 family protein; Region: TIGR03086 1306414004829 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1306414004830 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1306414004831 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1306414004832 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1306414004833 Beta-lactamase; Region: Beta-lactamase; pfam00144 1306414004834 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 1306414004835 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 1306414004836 NAD(P) binding site [chemical binding]; other site 1306414004837 catalytic residues [active] 1306414004838 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 1306414004839 putative catalytic residue [active] 1306414004840 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 1306414004841 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1306414004842 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1306414004843 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 1306414004844 putative substrate translocation pore; other site 1306414004845 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 1306414004846 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1306414004847 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1306414004848 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1306414004849 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1306414004850 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 1306414004851 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3742 1306414004852 putative active site [active] 1306414004853 Protein tyrosine kinase; Region: Pkinase_Tyr; pfam07714 1306414004854 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1306414004855 active site 1306414004856 ATP binding site [chemical binding]; other site 1306414004857 substrate binding site [chemical binding]; other site 1306414004858 activation loop (A-loop); other site 1306414004859 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1306414004860 Thioredoxin; Region: Thioredoxin_4; cl17273 1306414004861 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 1306414004862 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 1306414004863 active site 1306414004864 metal binding site [ion binding]; metal-binding site 1306414004865 nudix motif; other site 1306414004866 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1306414004867 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1306414004868 active site 1306414004869 ATP binding site [chemical binding]; other site 1306414004870 substrate binding site [chemical binding]; other site 1306414004871 activation loop (A-loop); other site 1306414004872 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1306414004873 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1306414004874 phosphopeptide binding site; other site 1306414004875 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1306414004876 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1306414004877 phosphopeptide binding site; other site 1306414004878 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 1306414004879 The Eye Pigment Precursor Transporter (EPP) Family protein; Region: 3a01204; TIGR00955 1306414004880 Walker A/P-loop; other site 1306414004881 ATP binding site [chemical binding]; other site 1306414004882 Q-loop/lid; other site 1306414004883 ABC transporter signature motif; other site 1306414004884 Walker B; other site 1306414004885 D-loop; other site 1306414004886 H-loop/switch region; other site 1306414004887 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1306414004888 acyl-CoA synthetase; Provisional; Region: PRK13388 1306414004889 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1306414004890 acyl-activating enzyme (AAE) consensus motif; other site 1306414004891 AMP binding site [chemical binding]; other site 1306414004892 active site 1306414004893 CoA binding site [chemical binding]; other site 1306414004894 hypothetical protein; Provisional; Region: PRK06185 1306414004895 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1306414004896 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1306414004897 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306414004898 PPE family; Region: PPE; pfam00823 1306414004899 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306414004900 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306414004901 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 1306414004902 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1306414004903 Cutinase; Region: Cutinase; pfam01083 1306414004904 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1306414004905 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1306414004906 Uncharacterized conserved protein [Function unknown]; Region: COG0393 1306414004907 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 1306414004908 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1306414004909 putative homotetramer interface [polypeptide binding]; other site 1306414004910 putative homodimer interface [polypeptide binding]; other site 1306414004911 putative allosteric switch controlling residues; other site 1306414004912 putative metal binding site [ion binding]; other site 1306414004913 putative homodimer-homodimer interface [polypeptide binding]; other site 1306414004914 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1306414004915 PE family; Region: PE; pfam00934 1306414004916 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1306414004917 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 1306414004918 dimer interface [polypeptide binding]; other site 1306414004919 active site 1306414004920 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1306414004921 substrate binding site [chemical binding]; other site 1306414004922 catalytic residue [active] 1306414004923 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 1306414004924 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1306414004925 metal binding site [ion binding]; metal-binding site 1306414004926 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 1306414004927 FAD binding domain; Region: FAD_binding_4; pfam01565 1306414004928 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1306414004929 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1306414004930 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1306414004931 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1306414004932 Bacterial transcriptional regulator; Region: IclR; pfam01614 1306414004933 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1306414004934 FAD binding domain; Region: FAD_binding_4; pfam01565 1306414004935 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306414004936 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306414004937 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1306414004938 Cytochrome P450; Region: p450; cl12078 1306414004939 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 1306414004940 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1306414004941 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1306414004942 Protein of unknown function (DUF690); Region: DUF690; pfam05108 1306414004943 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1306414004944 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1306414004945 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1306414004946 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1306414004947 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1306414004948 Cytochrome P450; Region: p450; cl12078 1306414004949 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1306414004950 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306414004951 PPE family; Region: PPE; pfam00823 1306414004952 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1306414004953 PE family; Region: PE; pfam00934 1306414004954 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306414004955 PPE family; Region: PPE; pfam00823 1306414004956 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1306414004957 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306414004958 PPE family; Region: PPE; pfam00823 1306414004959 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1306414004960 PE family; Region: PE; pfam00934 1306414004961 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1306414004962 EspG family; Region: ESX-1_EspG; pfam14011 1306414004963 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1306414004964 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1306414004965 catalytic residues [active] 1306414004966 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1306414004967 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 1306414004968 active site 1306414004969 catalytic residues [active] 1306414004970 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1306414004971 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1306414004972 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1306414004973 Walker A motif; other site 1306414004974 ATP binding site [chemical binding]; other site 1306414004975 Walker B motif; other site 1306414004976 arginine finger; other site 1306414004977 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306414004978 PPE family; Region: PPE; pfam00823 1306414004979 PE-PPE domain; Region: PE-PPE; pfam08237 1306414004980 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306414004981 PPE family; Region: PPE; pfam00823 1306414004982 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306414004983 PPE family; Region: PPE; pfam00823 1306414004984 PE family; Region: PE; pfam00934 1306414004985 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1306414004986 PE family; Region: PE; pfam00934 1306414004987 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306414004988 PPE family; Region: PPE; pfam00823 1306414004989 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306414004990 PPE family; Region: PPE; pfam00823 1306414004991 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306414004992 PPE family; Region: PPE; pfam00823 1306414004993 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1306414004994 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1306414004995 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1306414004996 MgtC family; Region: MgtC; pfam02308 1306414004997 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1306414004998 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1306414004999 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 1306414005000 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1306414005001 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1306414005002 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306414005003 hypothetical protein; Validated; Region: PRK07121 1306414005004 PE family; Region: PE; pfam00934 1306414005005 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 1306414005006 ABC transporter transmembrane region 2; Region: ABC_membrane_2; pfam06472 1306414005007 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 1306414005008 hypothetical protein; Provisional; Region: PRK05858 1306414005009 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1306414005010 PYR/PP interface [polypeptide binding]; other site 1306414005011 dimer interface [polypeptide binding]; other site 1306414005012 TPP binding site [chemical binding]; other site 1306414005013 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1306414005014 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 1306414005015 TPP-binding site; other site 1306414005016 dimer interface [polypeptide binding]; other site 1306414005017 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 1306414005018 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 1306414005019 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1306414005020 nucleotide binding region [chemical binding]; other site 1306414005021 ATP-binding site [chemical binding]; other site 1306414005022 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1306414005023 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1306414005024 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1306414005025 Uncharacterized conserved protein (small basic protein) [Function unknown]; Region: Sbp; COG3856 1306414005026 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1306414005027 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1306414005028 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1306414005029 lipoyl attachment site [posttranslational modification]; other site 1306414005030 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1306414005031 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1306414005032 phosphopeptide binding site; other site 1306414005033 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1306414005034 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1306414005035 DNA binding residues [nucleotide binding] 1306414005036 Bifunctional nuclease; Region: DNase-RNase; pfam02577 1306414005037 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1306414005038 DNA binding residues [nucleotide binding] 1306414005039 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1306414005040 putative dimer interface [polypeptide binding]; other site 1306414005041 glycine dehydrogenase; Provisional; Region: PRK05367 1306414005042 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1306414005043 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1306414005044 tetramer interface [polypeptide binding]; other site 1306414005045 catalytic residue [active] 1306414005046 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1306414005047 tetramer interface [polypeptide binding]; other site 1306414005048 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1306414005049 catalytic residue [active] 1306414005050 haloalkane dehalogenase; Provisional; Region: PRK03204 1306414005051 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1306414005052 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 1306414005053 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 1306414005054 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1306414005055 metal ion-dependent adhesion site (MIDAS); other site 1306414005056 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 1306414005057 active site 1306414005058 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1306414005059 putative active site [active] 1306414005060 Domain of unknown function DUF21; Region: DUF21; pfam01595 1306414005061 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1306414005062 FOG: CBS domain [General function prediction only]; Region: COG0517 1306414005063 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1306414005064 Domain of unknown function DUF21; Region: DUF21; pfam01595 1306414005065 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1306414005066 Transporter associated domain; Region: CorC_HlyC; smart01091 1306414005067 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 1306414005068 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1306414005069 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1306414005070 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1306414005071 active site 1306414005072 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1306414005073 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1306414005074 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1306414005075 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1306414005076 Predicted transcriptional regulator [Transcription]; Region: COG3682 1306414005077 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1306414005078 CoenzymeA binding site [chemical binding]; other site 1306414005079 subunit interaction site [polypeptide binding]; other site 1306414005080 PHB binding site; other site 1306414005081 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1306414005082 alpha-gamma subunit interface [polypeptide binding]; other site 1306414005083 beta-gamma subunit interface [polypeptide binding]; other site 1306414005084 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1306414005085 gamma-beta subunit interface [polypeptide binding]; other site 1306414005086 alpha-beta subunit interface [polypeptide binding]; other site 1306414005087 urease subunit alpha; Reviewed; Region: ureC; PRK13206 1306414005088 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1306414005089 subunit interactions [polypeptide binding]; other site 1306414005090 active site 1306414005091 flap region; other site 1306414005092 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1306414005093 UreF; Region: UreF; pfam01730 1306414005094 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1306414005095 UreD urease accessory protein; Region: UreD; cl00530 1306414005096 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1306414005097 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1306414005098 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1306414005099 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1306414005100 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1306414005101 classical (c) SDRs; Region: SDR_c; cd05233 1306414005102 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 1306414005103 NAD(P) binding site [chemical binding]; other site 1306414005104 active site 1306414005105 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1306414005106 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1306414005107 sulfate transport protein; Provisional; Region: cysT; CHL00187 1306414005108 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1306414005109 dimer interface [polypeptide binding]; other site 1306414005110 conserved gate region; other site 1306414005111 putative PBP binding loops; other site 1306414005112 ABC-ATPase subunit interface; other site 1306414005113 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 1306414005114 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1306414005115 Walker A/P-loop; other site 1306414005116 ATP binding site [chemical binding]; other site 1306414005117 Q-loop/lid; other site 1306414005118 ABC transporter signature motif; other site 1306414005119 Walker B; other site 1306414005120 D-loop; other site 1306414005121 H-loop/switch region; other site 1306414005122 TOBE domain; Region: TOBE; pfam03459 1306414005123 Fibronectin-attachment protein (FAP); Region: FAP; pfam07174 1306414005124 Predicted membrane protein [Function unknown]; Region: COG2261 1306414005125 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 1306414005126 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 1306414005127 putative NAD(P) binding site [chemical binding]; other site 1306414005128 putative substrate binding site [chemical binding]; other site 1306414005129 catalytic Zn binding site [ion binding]; other site 1306414005130 structural Zn binding site [ion binding]; other site 1306414005131 CAAX protease self-immunity; Region: Abi; pfam02517 1306414005132 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1306414005133 MOSC domain; Region: MOSC; pfam03473 1306414005134 short chain dehydrogenase; Provisional; Region: PRK07825 1306414005135 classical (c) SDRs; Region: SDR_c; cd05233 1306414005136 NAD(P) binding site [chemical binding]; other site 1306414005137 active site 1306414005138 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1306414005139 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1306414005140 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1306414005141 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1306414005142 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 1306414005143 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1306414005144 active site 1306414005145 hypothetical protein; Provisional; Region: PRK12320 1306414005146 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1306414005147 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1306414005148 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1306414005149 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1306414005150 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1306414005151 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 1306414005152 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 1306414005153 active site 1306414005154 substrate binding site [chemical binding]; other site 1306414005155 FMN binding site [chemical binding]; other site 1306414005156 putative catalytic residues [active] 1306414005157 Uncharacterized conserved protein [Function unknown]; Region: COG5579 1306414005158 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1306414005159 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1306414005160 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1306414005161 heme binding site [chemical binding]; other site 1306414005162 ferroxidase pore; other site 1306414005163 ferroxidase diiron center [ion binding]; other site 1306414005164 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1306414005165 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1306414005166 putative substrate translocation pore; other site 1306414005167 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1306414005168 putative substrate translocation pore; other site 1306414005169 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cl00333 1306414005170 23S rRNA interface [nucleotide binding]; other site 1306414005171 L3 interface [polypeptide binding]; other site 1306414005172 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1306414005173 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1306414005174 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1306414005175 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1306414005176 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1306414005177 Cytochrome P450; Region: p450; cl12078 1306414005178 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 1306414005179 short chain dehydrogenase; Provisional; Region: PRK08267 1306414005180 classical (c) SDR, subgroup 9; Region: SDR_c9; cd08931 1306414005181 putative NAD(P) binding site [chemical binding]; other site 1306414005182 active site 1306414005183 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1306414005184 hydrophobic ligand binding site; other site 1306414005185 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1306414005186 chorismate mutase; Provisional; Region: PRK09269 1306414005187 chorismate mutase, putative; Region: CM_mono2; TIGR01806 1306414005188 Putative esterase; Region: Esterase; pfam00756 1306414005189 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1306414005190 Nitronate monooxygenase; Region: NMO; pfam03060 1306414005191 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1306414005192 FMN binding site [chemical binding]; other site 1306414005193 substrate binding site [chemical binding]; other site 1306414005194 putative catalytic residue [active] 1306414005195 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1306414005196 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1306414005197 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1306414005198 putative active site [active] 1306414005199 dimerization interface [polypeptide binding]; other site 1306414005200 putative tRNAtyr binding site [nucleotide binding]; other site 1306414005201 Domain of unknown function DUF77; Region: DUF77; pfam01910 1306414005202 Macro domain, Unknown family 2. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_2; cd03330 1306414005203 putative ADP-ribose binding site [chemical binding]; other site 1306414005204 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1306414005205 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1306414005206 cyclase homology domain; Region: CHD; cd07302 1306414005207 nucleotidyl binding site; other site 1306414005208 metal binding site [ion binding]; metal-binding site 1306414005209 dimer interface [polypeptide binding]; other site 1306414005210 competence damage-inducible protein A; Provisional; Region: PRK00549 1306414005211 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1306414005212 putative MPT binding site; other site 1306414005213 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 1306414005214 putative sialic acid transporter; Region: 2A0112; TIGR00891 1306414005215 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1306414005216 putative substrate translocation pore; other site 1306414005217 Predicted membrane protein [Function unknown]; Region: COG1950 1306414005218 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1306414005219 anti sigma factor interaction site; other site 1306414005220 regulatory phosphorylation site [posttranslational modification]; other site 1306414005221 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1306414005222 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 1306414005223 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1306414005224 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 1306414005225 dimer interface [polypeptide binding]; other site 1306414005226 active site 1306414005227 heme binding site [chemical binding]; other site 1306414005228 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1306414005229 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1306414005230 metal binding site 2 [ion binding]; metal-binding site 1306414005231 putative DNA binding helix; other site 1306414005232 metal binding site 1 [ion binding]; metal-binding site 1306414005233 dimer interface [polypeptide binding]; other site 1306414005234 structural Zn2+ binding site [ion binding]; other site 1306414005235 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1306414005236 substrate binding site [chemical binding]; other site 1306414005237 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1306414005238 substrate binding site [chemical binding]; other site 1306414005239 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1306414005240 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1306414005241 tetramer interface [polypeptide binding]; other site 1306414005242 active site 1306414005243 Mg2+/Mn2+ binding site [ion binding]; other site 1306414005244 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 1306414005245 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306414005246 PPE family; Region: PPE; pfam00823 1306414005247 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306414005248 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306414005249 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306414005250 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306414005251 PPE family; Region: PPE; pfam00823 1306414005252 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306414005253 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306414005254 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1306414005255 putative hydrophobic ligand binding site [chemical binding]; other site 1306414005256 protein interface [polypeptide binding]; other site 1306414005257 gate; other site 1306414005258 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1306414005259 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1306414005260 putative acyl-acceptor binding pocket; other site 1306414005261 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1306414005262 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1306414005263 Beta-lactamase; Region: Beta-lactamase; pfam00144 1306414005264 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1306414005265 Beta-lactamase; Region: Beta-lactamase; pfam00144 1306414005266 putative fatty-acid--CoA ligase; Provisional; Region: PRK12476 1306414005267 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1306414005268 acyl-activating enzyme (AAE) consensus motif; other site 1306414005269 active site 1306414005270 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 1306414005271 Uncharacterized conserved protein [Function unknown]; Region: COG3361 1306414005272 short chain dehydrogenase; Provisional; Region: PRK05867 1306414005273 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1306414005274 NAD(P) binding site [chemical binding]; other site 1306414005275 active site 1306414005276 TIGR03085 family protein; Region: TIGR03085 1306414005277 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1306414005278 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1306414005279 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1306414005280 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1306414005281 dimer interface [polypeptide binding]; other site 1306414005282 catalytic triad [active] 1306414005283 peroxidatic and resolving cysteines [active] 1306414005284 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306414005285 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1306414005286 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1306414005287 active site 1306414005288 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306414005289 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 1306414005290 FAD binding site [chemical binding]; other site 1306414005291 substrate binding site [chemical binding]; other site 1306414005292 catalytic base [active] 1306414005293 enoyl-CoA hydratase; Provisional; Region: PRK08290 1306414005294 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1306414005295 substrate binding site [chemical binding]; other site 1306414005296 oxyanion hole (OAH) forming residues; other site 1306414005297 trimer interface [polypeptide binding]; other site 1306414005298 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1306414005299 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1306414005300 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 1306414005301 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1306414005302 catalytic loop [active] 1306414005303 iron binding site [ion binding]; other site 1306414005304 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 1306414005305 FAD binding pocket [chemical binding]; other site 1306414005306 FAD binding motif [chemical binding]; other site 1306414005307 phosphate binding motif [ion binding]; other site 1306414005308 beta-alpha-beta structure motif; other site 1306414005309 NAD binding pocket [chemical binding]; other site 1306414005310 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1306414005311 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1306414005312 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1306414005313 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 1306414005314 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1306414005315 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 1306414005316 dimerization interface [polypeptide binding]; other site 1306414005317 active site 1306414005318 classical (c) SDR, subgroup 12; Region: SDR_c12; cd08944 1306414005319 putative NAD(P) binding site [chemical binding]; other site 1306414005320 active site 1306414005321 homodimer interface [polypeptide binding]; other site 1306414005322 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1306414005323 SEC-C motif; Region: SEC-C; pfam02810 1306414005324 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1306414005325 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1306414005326 active site 1306414005327 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 1306414005328 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487 1306414005329 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 1306414005330 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1306414005331 non-specific DNA binding site [nucleotide binding]; other site 1306414005332 salt bridge; other site 1306414005333 sequence-specific DNA binding site [nucleotide binding]; other site 1306414005334 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 1306414005335 Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693 1306414005336 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 1306414005337 putative active site [active] 1306414005338 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1306414005339 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306414005340 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306414005341 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306414005342 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306414005343 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1306414005344 Permease; Region: Permease; pfam02405 1306414005345 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1306414005346 Permease; Region: Permease; pfam02405 1306414005347 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1306414005348 mce related protein; Region: MCE; pfam02470 1306414005349 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1306414005350 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1306414005351 mce related protein; Region: MCE; pfam02470 1306414005352 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1306414005353 mce related protein; Region: MCE; pfam02470 1306414005354 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1306414005355 mce related protein; Region: MCE; pfam02470 1306414005356 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1306414005357 mce related protein; Region: MCE; pfam02470 1306414005358 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1306414005359 mce related protein; Region: MCE; pfam02470 1306414005360 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1306414005361 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1306414005362 YacP-like NYN domain; Region: NYN_YacP; cl01491 1306414005363 Peptidase family M48; Region: Peptidase_M48; pfam01435 1306414005364 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306414005365 S-adenosylmethionine binding site [chemical binding]; other site 1306414005366 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1306414005367 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1306414005368 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1306414005369 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1306414005370 dimer interface [polypeptide binding]; other site 1306414005371 putative radical transfer pathway; other site 1306414005372 diiron center [ion binding]; other site 1306414005373 tyrosyl radical; other site 1306414005374 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 1306414005375 putative active site [active] 1306414005376 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 1306414005377 PE family; Region: PE; pfam00934 1306414005378 Cutinase; Region: Cutinase; pfam01083 1306414005379 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 1306414005380 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 1306414005381 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1306414005382 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1306414005383 dimerization interface [polypeptide binding]; other site 1306414005384 Lysine efflux permease [General function prediction only]; Region: COG1279 1306414005385 Cellulose binding domain; Region: CBM_2; pfam00553 1306414005386 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306414005387 S-adenosylmethionine binding site [chemical binding]; other site 1306414005388 Uncharacterized conserved protein [Function unknown]; Region: COG5654 1306414005389 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 1306414005390 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 1306414005391 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1306414005392 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1306414005393 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1306414005394 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1306414005395 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1306414005396 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 1306414005397 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1306414005398 dimerization interface [polypeptide binding]; other site 1306414005399 putative DNA binding site [nucleotide binding]; other site 1306414005400 putative Zn2+ binding site [ion binding]; other site 1306414005401 Hemerythrin-like domain; Region: Hr-like; cd12108 1306414005402 Fe binding site [ion binding]; other site 1306414005403 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1306414005404 Ligand Binding Site [chemical binding]; other site 1306414005405 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1306414005406 Ligand Binding Site [chemical binding]; other site 1306414005407 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1306414005408 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1306414005409 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1306414005410 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1306414005411 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1306414005412 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1306414005413 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1306414005414 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1306414005415 tetramer interface [polypeptide binding]; other site 1306414005416 active site 1306414005417 Mg2+/Mn2+ binding site [ion binding]; other site 1306414005418 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1306414005419 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1306414005420 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 1306414005421 3beta17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 3beta-17beta-HSD_like_SDR_c; cd05341 1306414005422 homotetramer interface [polypeptide binding]; other site 1306414005423 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1306414005424 NAD binding site [chemical binding]; other site 1306414005425 homodimer interface [polypeptide binding]; other site 1306414005426 active site 1306414005427 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1306414005428 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306414005429 S-adenosylmethionine binding site [chemical binding]; other site 1306414005430 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 1306414005431 Predicted kinase [General function prediction only]; Region: COG0645 1306414005432 AAA domain; Region: AAA_17; pfam13207 1306414005433 Universal stress protein family; Region: Usp; pfam00582 1306414005434 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1306414005435 Ligand Binding Site [chemical binding]; other site 1306414005436 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1306414005437 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 1306414005438 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 1306414005439 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1306414005440 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1306414005441 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1306414005442 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1306414005443 Ferredoxin [Energy production and conversion]; Region: COG1146 1306414005444 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1306414005445 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 1306414005446 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1306414005447 Walker A motif; other site 1306414005448 ATP binding site [chemical binding]; other site 1306414005449 Walker B motif; other site 1306414005450 arginine finger; other site 1306414005451 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1306414005452 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1306414005453 putative active site [active] 1306414005454 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1306414005455 MarR family; Region: MarR_2; pfam12802 1306414005456 Phage envelope protein [General function prediction only]; Region: COG5562 1306414005457 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1306414005458 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1306414005459 active site 1306414005460 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1306414005461 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1306414005462 non-specific DNA binding site [nucleotide binding]; other site 1306414005463 salt bridge; other site 1306414005464 sequence-specific DNA binding site [nucleotide binding]; other site 1306414005465 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 1306414005466 Uncharacterized conserved protein [Function unknown]; Region: COG2442 1306414005467 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1306414005468 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1306414005469 non-specific DNA binding site [nucleotide binding]; other site 1306414005470 salt bridge; other site 1306414005471 sequence-specific DNA binding site [nucleotide binding]; other site 1306414005472 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4683 1306414005473 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1306414005474 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1306414005475 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1306414005476 Ligand Binding Site [chemical binding]; other site 1306414005477 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1306414005478 Ligand Binding Site [chemical binding]; other site 1306414005479 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1306414005480 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1306414005481 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1306414005482 Histidine kinase; Region: HisKA_3; pfam07730 1306414005483 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1306414005484 Ligand Binding Site [chemical binding]; other site 1306414005485 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1306414005486 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1306414005487 putative substrate binding site [chemical binding]; other site 1306414005488 putative ATP binding site [chemical binding]; other site 1306414005489 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1306414005490 active site 1306414005491 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 1306414005492 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1306414005493 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1306414005494 putative dimer interface [polypeptide binding]; other site 1306414005495 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1306414005496 dimer interface [polypeptide binding]; other site 1306414005497 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 1306414005498 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1306414005499 putative DNA binding site [nucleotide binding]; other site 1306414005500 dimerization interface [polypeptide binding]; other site 1306414005501 putative Zn2+ binding site [ion binding]; other site 1306414005502 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 1306414005503 putative hydrophobic ligand binding site [chemical binding]; other site 1306414005504 CLM binding site; other site 1306414005505 L1 loop; other site 1306414005506 DNA binding site [nucleotide binding] 1306414005507 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1306414005508 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1306414005509 MDMPI C-terminal domain; Region: MDMPI_C; pfam07398 1306414005510 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1306414005511 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 1306414005512 nucleophile elbow; other site 1306414005513 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1306414005514 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1306414005515 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1306414005516 Walker A/P-loop; other site 1306414005517 ATP binding site [chemical binding]; other site 1306414005518 Q-loop/lid; other site 1306414005519 ABC transporter signature motif; other site 1306414005520 Walker B; other site 1306414005521 D-loop; other site 1306414005522 H-loop/switch region; other site 1306414005523 TOBE domain; Region: TOBE_2; pfam08402 1306414005524 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1306414005525 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1306414005526 dimer interface [polypeptide binding]; other site 1306414005527 conserved gate region; other site 1306414005528 putative PBP binding loops; other site 1306414005529 ABC-ATPase subunit interface; other site 1306414005530 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1306414005531 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1306414005532 dimer interface [polypeptide binding]; other site 1306414005533 conserved gate region; other site 1306414005534 putative PBP binding loops; other site 1306414005535 ABC-ATPase subunit interface; other site 1306414005536 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1306414005537 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1306414005538 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 1306414005539 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1306414005540 Isochorismatase family; Region: Isochorismatase; pfam00857 1306414005541 catalytic triad [active] 1306414005542 metal binding site [ion binding]; metal-binding site 1306414005543 conserved cis-peptide bond; other site 1306414005544 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 1306414005545 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1306414005546 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1306414005547 substrate binding pocket [chemical binding]; other site 1306414005548 catalytic triad [active] 1306414005549 hypothetical protein; Provisional; Region: PRK05865 1306414005550 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1306414005551 NAD(P) binding site [chemical binding]; other site 1306414005552 active site 1306414005553 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1306414005554 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1306414005555 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 1306414005556 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1306414005557 putative active site [active] 1306414005558 catalytic triad [active] 1306414005559 putative dimer interface [polypeptide binding]; other site 1306414005560 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 1306414005561 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 1306414005562 Ligand binding site; other site 1306414005563 Putative Catalytic site; other site 1306414005564 DXD motif; other site 1306414005565 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1306414005566 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1306414005567 active site 1306414005568 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 1306414005569 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1306414005570 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1306414005571 30S ribosomal protein S18; Provisional; Region: PRK13401 1306414005572 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1306414005573 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1306414005574 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1306414005575 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1306414005576 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1306414005577 intersubunit interface [polypeptide binding]; other site 1306414005578 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 1306414005579 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 1306414005580 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1306414005581 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1306414005582 precorrin-3B synthase; Region: CobG; TIGR02435 1306414005583 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1306414005584 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 1306414005585 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1306414005586 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1306414005587 active site 1306414005588 SAM binding site [chemical binding]; other site 1306414005589 homodimer interface [polypeptide binding]; other site 1306414005590 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1306414005591 active site 1306414005592 SAM binding site [chemical binding]; other site 1306414005593 homodimer interface [polypeptide binding]; other site 1306414005594 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1306414005595 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306414005596 S-adenosylmethionine binding site [chemical binding]; other site 1306414005597 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 1306414005598 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1306414005599 RNA polymerase sigma factor SigC; Reviewed; Region: PRK09649 1306414005600 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1306414005601 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1306414005602 DNA binding residues [nucleotide binding] 1306414005603 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1306414005604 active site 1306414005605 SAM binding site [chemical binding]; other site 1306414005606 homodimer interface [polypeptide binding]; other site 1306414005607 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1306414005608 active site 1306414005609 putative homodimer interface [polypeptide binding]; other site 1306414005610 SAM binding site [chemical binding]; other site 1306414005611 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1306414005612 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1306414005613 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1306414005614 NAD(P) binding site [chemical binding]; other site 1306414005615 active site 1306414005616 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1306414005617 Catalytic domain of uncharacterized Mycobacterium tuberculosis Rv2075c-like proteins; Region: PI-PLCc_Rv2075c_like; cd08590 1306414005618 putative active site [active] 1306414005619 catalytic site [active] 1306414005620 putative metal binding site [ion binding]; other site 1306414005621 C-type lectin (CTL)/C-type lectin-like (CTLD) domain; Region: CLECT; cl02432 1306414005622 Protein of unknown function (DUF2563); Region: DUF2563; pfam10817 1306414005623 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1306414005624 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1306414005625 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1306414005626 active site 1306414005627 ATP binding site [chemical binding]; other site 1306414005628 substrate binding site [chemical binding]; other site 1306414005629 activation loop (A-loop); other site 1306414005630 PknH-like extracellular domain; Region: PknH_C; pfam14032 1306414005631 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1306414005632 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1306414005633 active site 1306414005634 5'-3' exonuclease, N-terminal resolvase-like domain; Region: 5_3_exonuc_N; pfam02739 1306414005635 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1306414005636 active site 1306414005637 metal binding site 1 [ion binding]; metal-binding site 1306414005638 putative 5' ssDNA interaction site; other site 1306414005639 metal binding site 3; metal-binding site 1306414005640 metal binding site 2 [ion binding]; metal-binding site 1306414005641 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1306414005642 putative DNA binding site [nucleotide binding]; other site 1306414005643 putative metal binding site [ion binding]; other site 1306414005644 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 1306414005645 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 1306414005646 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1306414005647 ATP binding site [chemical binding]; other site 1306414005648 putative Mg++ binding site [ion binding]; other site 1306414005649 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1306414005650 nucleotide binding region [chemical binding]; other site 1306414005651 ATP-binding site [chemical binding]; other site 1306414005652 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 1306414005653 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1306414005654 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 1306414005655 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 1306414005656 Predicted transcriptional regulator [Transcription]; Region: COG2378 1306414005657 WYL domain; Region: WYL; pfam13280 1306414005658 Predicted transcriptional regulator [Transcription]; Region: COG2378 1306414005659 WYL domain; Region: WYL; pfam13280 1306414005660 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 1306414005661 PE family; Region: PE; pfam00934 1306414005662 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1306414005663 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1306414005664 active site 1306414005665 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1306414005666 SNF2 Helicase protein; Region: DUF3670; pfam12419 1306414005667 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1306414005668 ATP binding site [chemical binding]; other site 1306414005669 putative Mg++ binding site [ion binding]; other site 1306414005670 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1306414005671 nucleotide binding region [chemical binding]; other site 1306414005672 ATP-binding site [chemical binding]; other site 1306414005673 Uncharacterized conserved protein [Function unknown]; Region: COG4279 1306414005674 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1306414005675 putative active site [active] 1306414005676 PE family; Region: PE; pfam00934 1306414005677 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306414005678 PPE family; Region: PPE; pfam00823 1306414005679 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 1306414005680 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 1306414005681 active site 1306414005682 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 1306414005683 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 1306414005684 active site 1306414005685 Pup-like protein; Region: Pup; pfam05639 1306414005686 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 1306414005687 proteasome ATPase; Region: pup_AAA; TIGR03689 1306414005688 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1306414005689 Walker A motif; other site 1306414005690 ATP binding site [chemical binding]; other site 1306414005691 Walker B motif; other site 1306414005692 arginine finger; other site 1306414005693 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1306414005694 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550 1306414005695 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 1306414005696 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306414005697 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 1306414005698 Predicted membrane protein [Function unknown]; Region: COG3918 1306414005699 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1306414005700 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1306414005701 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1306414005702 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 1306414005703 homodimer interface [polypeptide binding]; other site 1306414005704 putative metal binding site [ion binding]; other site 1306414005705 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1306414005706 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 1306414005707 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1306414005708 substrate binding pocket [chemical binding]; other site 1306414005709 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1306414005710 B12 binding site [chemical binding]; other site 1306414005711 cobalt ligand [ion binding]; other site 1306414005712 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1306414005713 PAC2 family; Region: PAC2; pfam09754 1306414005714 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1306414005715 short chain dehydrogenase; Provisional; Region: PRK05872 1306414005716 classical (c) SDRs; Region: SDR_c; cd05233 1306414005717 NAD(P) binding site [chemical binding]; other site 1306414005718 active site 1306414005719 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1306414005720 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 1306414005721 active site 1306414005722 HIGH motif; other site 1306414005723 nucleotide binding site [chemical binding]; other site 1306414005724 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1306414005725 active site 1306414005726 KMSKS motif; other site 1306414005727 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 1306414005728 putative tRNA binding surface [nucleotide binding]; other site 1306414005729 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1306414005730 active site 1306414005731 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1306414005732 conserved hypothetical protein; Region: TIGR03843 1306414005733 conserved hypothetical protein; Region: TIGR03847 1306414005734 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1306414005735 catalytic core [active] 1306414005736 undecaprenyl-diphosphatase UppP; Region: undec_PP_bacA; TIGR00753 1306414005737 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1306414005738 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1306414005739 quinone interaction residues [chemical binding]; other site 1306414005740 active site 1306414005741 catalytic residues [active] 1306414005742 FMN binding site [chemical binding]; other site 1306414005743 substrate binding site [chemical binding]; other site 1306414005744 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1306414005745 substrate binding site [chemical binding]; other site 1306414005746 hypothetical protein; Provisional; Region: PRK07906 1306414005747 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 1306414005748 putative metal binding site [ion binding]; other site 1306414005749 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 1306414005750 putative addiction module component, TIGR02574 family; Region: stabl_TIGR02574 1306414005751 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1306414005752 active site 1306414005753 DivIVA domain; Region: DivI1A_domain; TIGR03544 1306414005754 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1306414005755 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1306414005756 Predicted integral membrane protein [Function unknown]; Region: COG0762 1306414005757 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 1306414005758 Predicted enzyme with a TIM-barrel fold [General function prediction only]; Region: COG0325 1306414005759 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1306414005760 catalytic residue [active] 1306414005761 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1306414005762 uncharacterized protein, YfiH family; Region: TIGR00726 1306414005763 cell division protein FtsZ; Validated; Region: PRK09330 1306414005764 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1306414005765 nucleotide binding site [chemical binding]; other site 1306414005766 SulA interaction site; other site 1306414005767 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1306414005768 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1306414005769 Cell division protein FtsQ; Region: FtsQ; pfam03799 1306414005770 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1306414005771 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1306414005772 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1306414005773 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1306414005774 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1306414005775 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1306414005776 active site 1306414005777 homodimer interface [polypeptide binding]; other site 1306414005778 cell division protein FtsW; Region: ftsW; TIGR02614 1306414005779 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369 1306414005780 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1306414005781 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1306414005782 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1306414005783 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1306414005784 Mg++ binding site [ion binding]; other site 1306414005785 putative catalytic motif [active] 1306414005786 putative substrate binding site [chemical binding]; other site 1306414005787 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 1306414005788 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1306414005789 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1306414005790 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1306414005791 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1306414005792 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1306414005793 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1306414005794 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1306414005795 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1306414005796 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1306414005797 PE family; Region: PE; pfam00934 1306414005798 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1306414005799 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1306414005800 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1306414005801 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 1306414005802 MraW methylase family; Region: Methyltransf_5; pfam01795 1306414005803 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 1306414005804 MraZ protein; Region: MraZ; pfam02381 1306414005805 MraZ protein; Region: MraZ; pfam02381 1306414005806 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 1306414005807 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 1306414005808 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1306414005809 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1306414005810 substrate binding pocket [chemical binding]; other site 1306414005811 chain length determination region; other site 1306414005812 substrate-Mg2+ binding site; other site 1306414005813 catalytic residues [active] 1306414005814 aspartate-rich region 1; other site 1306414005815 active site lid residues [active] 1306414005816 aspartate-rich region 2; other site 1306414005817 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1306414005818 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1306414005819 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1306414005820 active site 1306414005821 ATP binding site [chemical binding]; other site 1306414005822 substrate binding site [chemical binding]; other site 1306414005823 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1306414005824 substrate binding site [chemical binding]; other site 1306414005825 activation loop (A-loop); other site 1306414005826 activation loop (A-loop); other site 1306414005827 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1306414005828 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1306414005829 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG3200 1306414005830 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 1306414005831 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1306414005832 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1306414005833 putative acyl-acceptor binding pocket; other site 1306414005834 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1306414005835 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1306414005836 DTAP/Switch II; other site 1306414005837 Switch I; other site 1306414005838 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1306414005839 putative hydrophobic ligand binding site [chemical binding]; other site 1306414005840 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1306414005841 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1306414005842 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 1306414005843 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1306414005844 NlpC/P60 family; Region: NLPC_P60; pfam00877 1306414005845 hypothetical protein; Validated; Region: PRK07883 1306414005846 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1306414005847 active site 1306414005848 catalytic site [active] 1306414005849 substrate binding site [chemical binding]; other site 1306414005850 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1306414005851 GIY-YIG motif/motif A; other site 1306414005852 active site 1306414005853 catalytic site [active] 1306414005854 putative DNA binding site [nucleotide binding]; other site 1306414005855 metal binding site [ion binding]; metal-binding site 1306414005856 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 1306414005857 Subunit I/III interface [polypeptide binding]; other site 1306414005858 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1306414005859 Cytochrome c; Region: Cytochrom_C; pfam00034 1306414005860 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1306414005861 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1306414005862 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1306414005863 iron-sulfur cluster [ion binding]; other site 1306414005864 [2Fe-2S] cluster binding site [ion binding]; other site 1306414005865 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1306414005866 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1306414005867 heme bH binding site [chemical binding]; other site 1306414005868 intrachain domain interface; other site 1306414005869 heme bL binding site [chemical binding]; other site 1306414005870 interchain domain interface [polypeptide binding]; other site 1306414005871 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 1306414005872 Qo binding site; other site 1306414005873 Protein of unknown function (DUF2561); Region: DUF2561; pfam10812 1306414005874 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1306414005875 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 1306414005876 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1306414005877 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1306414005878 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1306414005879 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1306414005880 dimer interface [polypeptide binding]; other site 1306414005881 active site 1306414005882 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1306414005883 Ligand Binding Site [chemical binding]; other site 1306414005884 Molecular Tunnel; other site 1306414005885 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 1306414005886 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1306414005887 substrate binding site [chemical binding]; other site 1306414005888 ATP binding site [chemical binding]; other site 1306414005889 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1306414005890 Glycerate kinase family; Region: Gly_kinase; pfam02595 1306414005891 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 1306414005892 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1306414005893 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1306414005894 putative dimer interface [polypeptide binding]; other site 1306414005895 active site pocket [active] 1306414005896 putative cataytic base [active] 1306414005897 Cobalamin-5-phosphate synthase; Region: CobS; pfam02654 1306414005898 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1306414005899 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1306414005900 homodimer interface [polypeptide binding]; other site 1306414005901 substrate-cofactor binding pocket; other site 1306414005902 catalytic residue [active] 1306414005903 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1306414005904 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1306414005905 cyclase homology domain; Region: CHD; cd07302 1306414005906 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1306414005907 nucleotidyl binding site; other site 1306414005908 metal binding site [ion binding]; metal-binding site 1306414005909 dimer interface [polypeptide binding]; other site 1306414005910 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1306414005911 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1306414005912 interface (dimer of trimers) [polypeptide binding]; other site 1306414005913 Substrate-binding/catalytic site; other site 1306414005914 Zn-binding sites [ion binding]; other site 1306414005915 short chain dehydrogenase; Validated; Region: PRK05855 1306414005916 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1306414005917 classical (c) SDRs; Region: SDR_c; cd05233 1306414005918 NAD(P) binding site [chemical binding]; other site 1306414005919 active site 1306414005920 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 1306414005921 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1306414005922 E3 interaction surface; other site 1306414005923 lipoyl attachment site [posttranslational modification]; other site 1306414005924 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1306414005925 E3 interaction surface; other site 1306414005926 lipoyl attachment site [posttranslational modification]; other site 1306414005927 e3 binding domain; Region: E3_binding; pfam02817 1306414005928 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1306414005929 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1306414005930 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1306414005931 putative NAD(P) binding site [chemical binding]; other site 1306414005932 putative active site [active] 1306414005933 lipoate-protein ligase B; Provisional; Region: PRK14345 1306414005934 lipoyl synthase; Provisional; Region: PRK05481 1306414005935 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1306414005936 FeS/SAM binding site; other site 1306414005937 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 1306414005938 RDD family; Region: RDD; pfam06271 1306414005939 glutamine synthetase, type I; Region: GlnA; TIGR00653 1306414005940 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1306414005941 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1306414005942 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 1306414005943 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1306414005944 metal binding triad; other site 1306414005945 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1306414005946 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1306414005947 metal binding triad; other site 1306414005948 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1306414005949 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1306414005950 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1306414005951 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1306414005952 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1306414005953 TAP-like protein; Region: Abhydrolase_4; pfam08386 1306414005954 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1306414005955 TAP-like protein; Region: Abhydrolase_4; pfam08386 1306414005956 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1306414005957 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1306414005958 oligomerization interface [polypeptide binding]; other site 1306414005959 active site 1306414005960 metal binding site [ion binding]; metal-binding site 1306414005961 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 1306414005962 putative active site; other site 1306414005963 putative metal binding residues [ion binding]; other site 1306414005964 signature motif; other site 1306414005965 putative triphosphate binding site [ion binding]; other site 1306414005966 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 1306414005967 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3826 1306414005968 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 1306414005969 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1306414005970 RNA/DNA hybrid binding site [nucleotide binding]; other site 1306414005971 active site 1306414005972 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1306414005973 catalytic core [active] 1306414005974 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 1306414005975 Putative zinc ribbon domain; Region: DUF164; pfam02591 1306414005976 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 1306414005977 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1306414005978 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1306414005979 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1306414005980 hypothetical protein; Provisional; Region: PRK07908 1306414005981 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1306414005982 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1306414005983 homodimer interface [polypeptide binding]; other site 1306414005984 catalytic residue [active] 1306414005985 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1306414005986 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1306414005987 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1306414005988 active site 1306414005989 motif I; other site 1306414005990 motif II; other site 1306414005991 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1306414005992 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1306414005993 active site 1306414005994 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1306414005995 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 1306414005996 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 1306414005997 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1306414005998 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 1306414005999 dimer interface [polypeptide binding]; other site 1306414006000 catalytic triad [active] 1306414006001 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 1306414006002 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1306414006003 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1306414006004 dimer interface [polypeptide binding]; other site 1306414006005 TPP-binding site [chemical binding]; other site 1306414006006 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1306414006007 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1306414006008 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1306414006009 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1306414006010 acyl carrier protein; Provisional; Region: acpP; PRK00982 1306414006011 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 1306414006012 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1306414006013 dimer interface [polypeptide binding]; other site 1306414006014 active site 1306414006015 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 1306414006016 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1306414006017 dimer interface [polypeptide binding]; other site 1306414006018 active site 1306414006019 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1306414006020 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1306414006021 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1306414006022 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1306414006023 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1306414006024 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1306414006025 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306414006026 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306414006027 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1306414006028 FAD binding domain; Region: FAD_binding_4; pfam01565 1306414006029 diacylglycerol kinase; Reviewed; Region: PRK11914 1306414006030 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1306414006031 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 1306414006032 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1306414006033 Beta-lactamase; Region: Beta-lactamase; pfam00144 1306414006034 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1306414006035 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306414006036 S-adenosylmethionine binding site [chemical binding]; other site 1306414006037 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 1306414006038 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1306414006039 NAD binding site [chemical binding]; other site 1306414006040 catalytic Zn binding site [ion binding]; other site 1306414006041 substrate binding site [chemical binding]; other site 1306414006042 structural Zn binding site [ion binding]; other site 1306414006043 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1306414006044 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 1306414006045 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1306414006046 putative active site [active] 1306414006047 catalytic triad [active] 1306414006048 putative dimer interface [polypeptide binding]; other site 1306414006049 short chain dehydrogenase; Provisional; Region: PRK05854 1306414006050 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1306414006051 putative NAD(P) binding site [chemical binding]; other site 1306414006052 active site 1306414006053 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1306414006054 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1306414006055 Cytochrome P450; Region: p450; cl12078 1306414006056 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1306414006057 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1306414006058 Cytochrome P450; Region: p450; cl12078 1306414006059 Septum formation; Region: Septum_form; pfam13845 1306414006060 Protein of unknown function (DUF2695); Region: DUF2695; pfam10905 1306414006061 Predicted membrane protein [Function unknown]; Region: COG2149 1306414006062 Domain of unknown function (DUF202); Region: DUF202; pfam02656 1306414006063 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1306414006064 Cytochrome P450; Region: p450; cl12078 1306414006065 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial protein Rv2277c and similar proteins; Region: GDPD_Rv2277c_like; cd08580 1306414006066 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1306414006067 putative active site [active] 1306414006068 catalytic site [active] 1306414006069 putative metal binding site [ion binding]; other site 1306414006070 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1306414006071 FAD binding domain; Region: FAD_binding_4; pfam01565 1306414006072 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1306414006073 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1306414006074 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1306414006075 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1306414006076 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1306414006077 dimerization interface [polypeptide binding]; other site 1306414006078 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1306414006079 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1306414006080 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1306414006081 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1306414006082 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1306414006083 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1306414006084 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1306414006085 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1306414006086 CDP-diacylglycerol pyrophosphatase [Lipid metabolism]; Region: Cdh; COG2134 1306414006087 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1306414006088 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1306414006089 active site residue [active] 1306414006090 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1306414006091 active site residue [active] 1306414006092 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1306414006093 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1306414006094 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1306414006095 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1306414006096 homodimer interface [polypeptide binding]; other site 1306414006097 catalytic residue [active] 1306414006098 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3196 1306414006099 haloalkane dehalogenase; Provisional; Region: PRK00870 1306414006100 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1306414006101 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1306414006102 active site 1306414006103 catalytic tetrad [active] 1306414006104 heat shock protein 90; Provisional; Region: PRK05218 1306414006105 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1306414006106 ATP binding site [chemical binding]; other site 1306414006107 Mg2+ binding site [ion binding]; other site 1306414006108 G-X-G motif; other site 1306414006109 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1306414006110 Cutinase; Region: Cutinase; pfam01083 1306414006111 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 1306414006112 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1306414006113 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 1306414006114 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1306414006115 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1306414006116 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1306414006117 Uncharacterized conserved protein [Function unknown]; Region: COG2442 1306414006118 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1306414006119 DNA binding site [nucleotide binding] 1306414006120 active site 1306414006121 Int/Topo IB signature motif; other site 1306414006122 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1306414006123 DNA binding residues [nucleotide binding] 1306414006124 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507 1306414006125 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1306414006126 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1306414006127 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1306414006128 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1306414006129 putative PBP binding loops; other site 1306414006130 ABC-ATPase subunit interface; other site 1306414006131 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1306414006132 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1306414006133 dimer interface [polypeptide binding]; other site 1306414006134 conserved gate region; other site 1306414006135 putative PBP binding loops; other site 1306414006136 ABC-ATPase subunit interface; other site 1306414006137 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1306414006138 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1306414006139 amino acid transporter; Region: 2A0306; TIGR00909 1306414006140 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1306414006141 Amidinotransferase; Region: Amidinotransf; pfam02274 1306414006142 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1306414006143 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1306414006144 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1306414006145 putative DNA binding site [nucleotide binding]; other site 1306414006146 putative Zn2+ binding site [ion binding]; other site 1306414006147 AsnC family; Region: AsnC_trans_reg; pfam01037 1306414006148 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1306414006149 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1306414006150 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1306414006151 Walker A/P-loop; other site 1306414006152 ATP binding site [chemical binding]; other site 1306414006153 Q-loop/lid; other site 1306414006154 ABC transporter signature motif; other site 1306414006155 Walker B; other site 1306414006156 D-loop; other site 1306414006157 H-loop/switch region; other site 1306414006158 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1306414006159 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1306414006160 Walker A/P-loop; other site 1306414006161 ATP binding site [chemical binding]; other site 1306414006162 Q-loop/lid; other site 1306414006163 ABC transporter signature motif; other site 1306414006164 Walker B; other site 1306414006165 D-loop; other site 1306414006166 H-loop/switch region; other site 1306414006167 MarR family; Region: MarR; pfam01047 1306414006168 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1306414006169 PE family; Region: PE; pfam00934 1306414006170 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1306414006171 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1306414006172 putative substrate translocation pore; other site 1306414006173 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 1306414006174 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1306414006175 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1306414006176 malate dehydrogenase; Provisional; Region: PRK13529 1306414006177 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1306414006178 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1306414006179 NAD(P) binding site [chemical binding]; other site 1306414006180 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1306414006181 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1306414006182 putative substrate translocation pore; other site 1306414006183 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1306414006184 putative substrate translocation pore; other site 1306414006185 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1306414006186 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1306414006187 dimer interface [polypeptide binding]; other site 1306414006188 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1306414006189 catalytic residue [active] 1306414006190 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 1306414006191 serine O-acetyltransferase; Region: cysE; TIGR01172 1306414006192 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1306414006193 trimer interface [polypeptide binding]; other site 1306414006194 active site 1306414006195 substrate binding site [chemical binding]; other site 1306414006196 CoA binding site [chemical binding]; other site 1306414006197 hypothetical protein; Provisional; Region: PRK14851 1306414006198 hypothetical protein; Validated; Region: PRK08223 1306414006199 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 1306414006200 ATP binding site [chemical binding]; other site 1306414006201 substrate interface [chemical binding]; other site 1306414006202 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1306414006203 DNA primase; Validated; Region: dnaG; PRK05667 1306414006204 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1306414006205 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1306414006206 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1306414006207 active site 1306414006208 metal binding site [ion binding]; metal-binding site 1306414006209 interdomain interaction site; other site 1306414006210 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1306414006211 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 1306414006212 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 1306414006213 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1306414006214 Zn2+ binding site [ion binding]; other site 1306414006215 Mg2+ binding site [ion binding]; other site 1306414006216 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1306414006217 Repair protein; Region: Repair_PSII; pfam04536 1306414006218 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1306414006219 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1306414006220 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 1306414006221 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1306414006222 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 1306414006223 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1306414006224 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 1306414006225 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1306414006226 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306414006227 PPE family; Region: PPE; pfam00823 1306414006228 PPE family; Region: PPE; pfam00823 1306414006229 PPE family; Region: PPE; pfam00823 1306414006230 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1306414006231 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1306414006232 motif 1; other site 1306414006233 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1306414006234 active site 1306414006235 motif 2; other site 1306414006236 motif 3; other site 1306414006237 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1306414006238 anticodon binding site; other site 1306414006239 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1306414006240 dimerization interface [polypeptide binding]; other site 1306414006241 putative DNA binding site [nucleotide binding]; other site 1306414006242 putative Zn2+ binding site [ion binding]; other site 1306414006243 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1306414006244 metal binding site 2 [ion binding]; metal-binding site 1306414006245 putative DNA binding helix; other site 1306414006246 metal binding site 1 [ion binding]; metal-binding site 1306414006247 dimer interface [polypeptide binding]; other site 1306414006248 structural Zn2+ binding site [ion binding]; other site 1306414006249 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1306414006250 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1306414006251 catalytic residue [active] 1306414006252 putative FPP diphosphate binding site; other site 1306414006253 putative FPP binding hydrophobic cleft; other site 1306414006254 dimer interface [polypeptide binding]; other site 1306414006255 putative IPP diphosphate binding site; other site 1306414006256 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1306414006257 Recombination protein O N terminal; Region: RecO_N; pfam11967 1306414006258 Recombination protein O C terminal; Region: RecO_C; pfam02565 1306414006259 amidase; Provisional; Region: PRK06061 1306414006260 Amidase; Region: Amidase; pfam01425 1306414006261 GTPase Era; Reviewed; Region: era; PRK00089 1306414006262 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1306414006263 G1 box; other site 1306414006264 GTP/Mg2+ binding site [chemical binding]; other site 1306414006265 Switch I region; other site 1306414006266 G2 box; other site 1306414006267 Switch II region; other site 1306414006268 G3 box; other site 1306414006269 G4 box; other site 1306414006270 G5 box; other site 1306414006271 KH domain; Region: KH_2; pfam07650 1306414006272 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1306414006273 Domain of unknown function DUF21; Region: DUF21; pfam01595 1306414006274 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1306414006275 Transporter associated domain; Region: CorC_HlyC; smart01091 1306414006276 metal-binding heat shock protein; Provisional; Region: PRK00016 1306414006277 K homology RNA-binding domain; Region: KH; smart00322 1306414006278 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1306414006279 PhoH-like protein; Region: PhoH; pfam02562 1306414006280 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1306414006281 PE family; Region: PE; pfam00934 1306414006282 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1306414006283 RNA methyltransferase, RsmE family; Region: TIGR00046 1306414006284 chaperone protein DnaJ; Provisional; Region: PRK14278 1306414006285 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1306414006286 HSP70 interaction site [polypeptide binding]; other site 1306414006287 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1306414006288 Zn binding sites [ion binding]; other site 1306414006289 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1306414006290 dimer interface [polypeptide binding]; other site 1306414006291 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1306414006292 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1306414006293 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 1306414006294 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1306414006295 Condensation domain; Region: Condensation; pfam00668 1306414006296 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1306414006297 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1306414006298 acyl-activating enzyme (AAE) consensus motif; other site 1306414006299 AMP binding site [chemical binding]; other site 1306414006300 Condensation domain; Region: Condensation; pfam00668 1306414006301 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1306414006302 Condensation domain; Region: Condensation; pfam00668 1306414006303 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1306414006304 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1306414006305 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1306414006306 acyl-activating enzyme (AAE) consensus motif; other site 1306414006307 AMP binding site [chemical binding]; other site 1306414006308 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1306414006309 Condensation domain; Region: Condensation; pfam00668 1306414006310 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1306414006311 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1306414006312 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1306414006313 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1306414006314 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1306414006315 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1306414006316 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 1306414006317 NADP binding site [chemical binding]; other site 1306414006318 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1306414006319 active site 1306414006320 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1306414006321 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1306414006322 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1306414006323 active site 1306414006324 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1306414006325 Condensation domain; Region: Condensation; pfam00668 1306414006326 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1306414006327 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1306414006328 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 1306414006329 acyl-activating enzyme (AAE) consensus motif; other site 1306414006330 AMP binding site [chemical binding]; other site 1306414006331 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1306414006332 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1306414006333 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 1306414006334 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1306414006335 acyl-activating enzyme (AAE) consensus motif; other site 1306414006336 active site 1306414006337 AMP binding site [chemical binding]; other site 1306414006338 substrate binding site [chemical binding]; other site 1306414006339 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1306414006340 salicylate synthase MbtI; Reviewed; Region: PRK07912 1306414006341 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1306414006342 Predicted permease [General function prediction only]; Region: COG3329 1306414006343 coproporphyrinogen III oxidase; Validated; Region: PRK05628 1306414006344 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1306414006345 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1306414006346 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1306414006347 Active Sites [active] 1306414006348 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1306414006349 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1306414006350 putative active site [active] 1306414006351 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1306414006352 putative active site [active] 1306414006353 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1306414006354 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1306414006355 Predicted membrane protein [Function unknown]; Region: COG1297 1306414006356 putative oligopeptide transporter, OPT family; Region: TIGR00733 1306414006357 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1306414006358 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 1306414006359 Walker A/P-loop; other site 1306414006360 ATP binding site [chemical binding]; other site 1306414006361 Q-loop/lid; other site 1306414006362 ABC transporter signature motif; other site 1306414006363 Walker B; other site 1306414006364 D-loop; other site 1306414006365 H-loop/switch region; other site 1306414006366 sulfate transport protein; Provisional; Region: cysT; CHL00187 1306414006367 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1306414006368 dimer interface [polypeptide binding]; other site 1306414006369 conserved gate region; other site 1306414006370 putative PBP binding loops; other site 1306414006371 ABC-ATPase subunit interface; other site 1306414006372 sulfate transport protein; Provisional; Region: cysT; CHL00187 1306414006373 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1306414006374 dimer interface [polypeptide binding]; other site 1306414006375 conserved gate region; other site 1306414006376 putative PBP binding loops; other site 1306414006377 ABC-ATPase subunit interface; other site 1306414006378 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 1306414006379 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1306414006380 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1306414006381 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1306414006382 PknH-like extracellular domain; Region: PknH_C; pfam14032 1306414006383 GTP-binding protein LepA; Provisional; Region: PRK05433 1306414006384 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1306414006385 G1 box; other site 1306414006386 putative GEF interaction site [polypeptide binding]; other site 1306414006387 GTP/Mg2+ binding site [chemical binding]; other site 1306414006388 Switch I region; other site 1306414006389 G2 box; other site 1306414006390 G3 box; other site 1306414006391 Switch II region; other site 1306414006392 G4 box; other site 1306414006393 G5 box; other site 1306414006394 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1306414006395 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1306414006396 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1306414006397 PemK-like protein; Region: PemK; pfam02452 1306414006398 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 1306414006399 FOG: CBS domain [General function prediction only]; Region: COG0517 1306414006400 ribonuclease Z; Reviewed; Region: PRK00055 1306414006401 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1306414006402 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1306414006403 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1306414006404 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1306414006405 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1306414006406 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1306414006407 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1306414006408 hypothetical protein; Reviewed; Region: PRK07914 1306414006409 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1306414006410 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1306414006411 Competence protein; Region: Competence; pfam03772 1306414006412 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1306414006413 Helix-hairpin-helix motif; Region: HHH; pfam00633 1306414006414 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 1306414006415 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1306414006416 Coenzyme A binding pocket [chemical binding]; other site 1306414006417 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 1306414006418 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1306414006419 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1306414006420 active site 1306414006421 catalytic triad [active] 1306414006422 oxyanion hole [active] 1306414006423 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1306414006424 catalytic core [active] 1306414006425 Oligomerisation domain; Region: Oligomerisation; cl00519 1306414006426 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1306414006427 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1306414006428 active site 1306414006429 (T/H)XGH motif; other site 1306414006430 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1306414006431 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306414006432 S-adenosylmethionine binding site [chemical binding]; other site 1306414006433 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1306414006434 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1306414006435 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1306414006436 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 1306414006437 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1306414006438 metal ion-dependent adhesion site (MIDAS); other site 1306414006439 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1306414006440 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1306414006441 Walker A motif; other site 1306414006442 ATP binding site [chemical binding]; other site 1306414006443 Walker B motif; other site 1306414006444 arginine finger; other site 1306414006445 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1306414006446 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1306414006447 putative catalytic cysteine [active] 1306414006448 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1306414006449 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1306414006450 dimer interface [polypeptide binding]; other site 1306414006451 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1306414006452 catalytic triad [active] 1306414006453 peroxidatic and resolving cysteines [active] 1306414006454 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 1306414006455 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 1306414006456 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306414006457 PPE family; Region: PPE; pfam00823 1306414006458 PE family; Region: PE; pfam00934 1306414006459 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1306414006460 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1306414006461 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1306414006462 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1306414006463 ligand binding site [chemical binding]; other site 1306414006464 flexible hinge region; other site 1306414006465 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1306414006466 dimerization interface [polypeptide binding]; other site 1306414006467 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1306414006468 cyclase homology domain; Region: CHD; cd07302 1306414006469 nucleotidyl binding site; other site 1306414006470 metal binding site [ion binding]; metal-binding site 1306414006471 dimer interface [polypeptide binding]; other site 1306414006472 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1306414006473 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1306414006474 substrate binding site [chemical binding]; other site 1306414006475 dimer interface [polypeptide binding]; other site 1306414006476 ATP binding site [chemical binding]; other site 1306414006477 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1306414006478 NAD synthetase; Reviewed; Region: nadE; PRK02628 1306414006479 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1306414006480 multimer interface [polypeptide binding]; other site 1306414006481 active site 1306414006482 catalytic triad [active] 1306414006483 protein interface 1 [polypeptide binding]; other site 1306414006484 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1306414006485 homodimer interface [polypeptide binding]; other site 1306414006486 NAD binding pocket [chemical binding]; other site 1306414006487 ATP binding pocket [chemical binding]; other site 1306414006488 Mg binding site [ion binding]; other site 1306414006489 active-site loop [active] 1306414006490 gamma-glutamyl kinase; Provisional; Region: PRK05429 1306414006491 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1306414006492 nucleotide binding site [chemical binding]; other site 1306414006493 homotetrameric interface [polypeptide binding]; other site 1306414006494 putative phosphate binding site [ion binding]; other site 1306414006495 putative allosteric binding site; other site 1306414006496 PUA domain; Region: PUA; pfam01472 1306414006497 GTPase CgtA; Reviewed; Region: obgE; PRK12296 1306414006498 GTP1/OBG; Region: GTP1_OBG; pfam01018 1306414006499 Obg GTPase; Region: Obg; cd01898 1306414006500 G1 box; other site 1306414006501 GTP/Mg2+ binding site [chemical binding]; other site 1306414006502 Switch I region; other site 1306414006503 G2 box; other site 1306414006504 G3 box; other site 1306414006505 Switch II region; other site 1306414006506 G4 box; other site 1306414006507 G5 box; other site 1306414006508 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1306414006509 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1306414006510 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1306414006511 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1306414006512 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1306414006513 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1306414006514 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1306414006515 homodimer interface [polypeptide binding]; other site 1306414006516 oligonucleotide binding site [chemical binding]; other site 1306414006517 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1306414006518 active site 1306414006519 multimer interface [polypeptide binding]; other site 1306414006520 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 1306414006521 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1306414006522 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1306414006523 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1306414006524 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1306414006525 active site 1306414006526 HIGH motif; other site 1306414006527 nucleotide binding site [chemical binding]; other site 1306414006528 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1306414006529 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1306414006530 active site 1306414006531 KMSKS motif; other site 1306414006532 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1306414006533 tRNA binding surface [nucleotide binding]; other site 1306414006534 anticodon binding site; other site 1306414006535 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1306414006536 Uncharacterized conserved protein [Function unknown]; Region: COG3268 1306414006537 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1306414006538 NAD(P) binding pocket [chemical binding]; other site 1306414006539 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1306414006540 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1306414006541 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1306414006542 GTP binding site; other site 1306414006543 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 1306414006544 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 1306414006545 TPP-binding site [chemical binding]; other site 1306414006546 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1306414006547 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 1306414006548 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1306414006549 dimer interface [polypeptide binding]; other site 1306414006550 PYR/PP interface [polypeptide binding]; other site 1306414006551 TPP binding site [chemical binding]; other site 1306414006552 substrate binding site [chemical binding]; other site 1306414006553 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1306414006554 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1306414006555 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1306414006556 Walker A motif; other site 1306414006557 ATP binding site [chemical binding]; other site 1306414006558 Walker B motif; other site 1306414006559 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1306414006560 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 1306414006561 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1306414006562 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1306414006563 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1306414006564 putative substrate translocation pore; other site 1306414006565 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1306414006566 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1306414006567 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1306414006568 oligomer interface [polypeptide binding]; other site 1306414006569 active site residues [active] 1306414006570 Clp protease; Region: CLP_protease; pfam00574 1306414006571 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1306414006572 oligomer interface [polypeptide binding]; other site 1306414006573 active site residues [active] 1306414006574 trigger factor; Provisional; Region: tig; PRK01490 1306414006575 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1306414006576 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1306414006577 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1306414006578 Beta-lactamase; Region: Beta-lactamase; pfam00144 1306414006579 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1306414006580 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 1306414006581 putative DNA binding site [nucleotide binding]; other site 1306414006582 catalytic residue [active] 1306414006583 putative H2TH interface [polypeptide binding]; other site 1306414006584 putative catalytic residues [active] 1306414006585 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1306414006586 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1306414006587 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1306414006588 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1306414006589 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1306414006590 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 1306414006591 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 1306414006592 Zn binding site [ion binding]; other site 1306414006593 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1306414006594 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1306414006595 active site 1306414006596 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1306414006597 apolar tunnel; other site 1306414006598 heme binding site [chemical binding]; other site 1306414006599 dimerization interface [polypeptide binding]; other site 1306414006600 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 1306414006601 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1306414006602 active site 1306414006603 catalytic site [active] 1306414006604 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1306414006605 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1306414006606 active site 1306414006607 NAD-specific glutamate dehydrogenase [Amino acid transport and metabolism]; Region: COG2902 1306414006608 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1306414006609 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1306414006610 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1306414006611 ABC transporter; Region: ABC_tran_2; pfam12848 1306414006612 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1306414006613 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1306414006614 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1306414006615 dimer interface [polypeptide binding]; other site 1306414006616 ssDNA binding site [nucleotide binding]; other site 1306414006617 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1306414006618 glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355 1306414006619 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1306414006620 putative acyl-acceptor binding pocket; other site 1306414006621 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1306414006622 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 1306414006623 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1306414006624 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1306414006625 putative acyl-acceptor binding pocket; other site 1306414006626 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1306414006627 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1306414006628 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1306414006629 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1306414006630 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1306414006631 enoyl-CoA hydratase; Provisional; Region: PRK05870 1306414006632 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1306414006633 substrate binding site [chemical binding]; other site 1306414006634 oxyanion hole (OAH) forming residues; other site 1306414006635 trimer interface [polypeptide binding]; other site 1306414006636 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK14653 1306414006637 PE family; Region: PE; pfam00934 1306414006638 TIGR00725 family protein; Region: TIGR00725 1306414006639 thymidylate synthase; Provisional; Region: thyA; PRK00956 1306414006640 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1306414006641 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1306414006642 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1306414006643 E3 interaction surface; other site 1306414006644 lipoyl attachment site [posttranslational modification]; other site 1306414006645 e3 binding domain; Region: E3_binding; pfam02817 1306414006646 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1306414006647 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1306414006648 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1306414006649 alpha subunit interface [polypeptide binding]; other site 1306414006650 TPP binding site [chemical binding]; other site 1306414006651 heterodimer interface [polypeptide binding]; other site 1306414006652 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1306414006653 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1306414006654 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1306414006655 tetramer interface [polypeptide binding]; other site 1306414006656 TPP-binding site [chemical binding]; other site 1306414006657 heterodimer interface [polypeptide binding]; other site 1306414006658 phosphorylation loop region [posttranslational modification] 1306414006659 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1306414006660 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 1306414006661 putative active site [active] 1306414006662 putative catalytic site [active] 1306414006663 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306414006664 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1306414006665 active site 1306414006666 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1306414006667 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1306414006668 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1306414006669 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1306414006670 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1306414006671 carboxyltransferase (CT) interaction site; other site 1306414006672 biotinylation site [posttranslational modification]; other site 1306414006673 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1306414006674 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1306414006675 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1306414006676 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1306414006677 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1306414006678 AMP-binding domain protein; Validated; Region: PRK08315 1306414006679 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1306414006680 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1306414006681 acyl-activating enzyme (AAE) consensus motif; other site 1306414006682 acyl-activating enzyme (AAE) consensus motif; other site 1306414006683 putative AMP binding site [chemical binding]; other site 1306414006684 putative active site [active] 1306414006685 putative CoA binding site [chemical binding]; other site 1306414006686 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306414006687 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306414006688 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1306414006689 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1306414006690 classical (c) SDRs; Region: SDR_c; cd05233 1306414006691 NAD(P) binding site [chemical binding]; other site 1306414006692 active site 1306414006693 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 1306414006694 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1306414006695 catalytic site [active] 1306414006696 putative active site [active] 1306414006697 putative substrate binding site [chemical binding]; other site 1306414006698 dimer interface [polypeptide binding]; other site 1306414006699 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1306414006700 MULE transposase domain; Region: MULE; pfam10551 1306414006701 Domain of unknown function (DUF4411); Region: DUF4411; pfam14367 1306414006702 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1306414006703 non-specific DNA binding site [nucleotide binding]; other site 1306414006704 salt bridge; other site 1306414006705 sequence-specific DNA binding site [nucleotide binding]; other site 1306414006706 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 1306414006707 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893 1306414006708 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1306414006709 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1306414006710 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1306414006711 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1306414006712 PE family; Region: PE; pfam00934 1306414006713 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 1306414006714 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1306414006715 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1306414006716 catalytic triad [active] 1306414006717 hypothetical protein; Provisional; Region: PRK07907 1306414006718 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 1306414006719 active site 1306414006720 metal binding site [ion binding]; metal-binding site 1306414006721 dimer interface [polypeptide binding]; other site 1306414006722 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1306414006723 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1306414006724 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 1306414006725 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1306414006726 phosphate binding site [ion binding]; other site 1306414006727 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 1306414006728 FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447 1306414006729 putative active site [active] 1306414006730 putative catalytic site [active] 1306414006731 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1306414006732 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1306414006733 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 1306414006734 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 1306414006735 putative NAD(P) binding site [chemical binding]; other site 1306414006736 active site 1306414006737 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 1306414006738 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1306414006739 active site 1306414006740 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 1306414006741 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1306414006742 putative active site [active] 1306414006743 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 1306414006744 Mrr N-terminal domain; Region: Mrr_N; pfam14338 1306414006745 Restriction endonuclease; Region: Mrr_cat; pfam04471 1306414006746 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1306414006747 ERCC4 domain; Region: ERCC4; pfam02732 1306414006748 Lsr2; Region: Lsr2; pfam11774 1306414006749 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1306414006750 putative active site [active] 1306414006751 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1306414006752 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1306414006753 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1306414006754 catalytic residue [active] 1306414006755 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1306414006756 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1306414006757 putative RNA binding site [nucleotide binding]; other site 1306414006758 elongation factor P; Validated; Region: PRK00529 1306414006759 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1306414006760 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1306414006761 RNA binding site [nucleotide binding]; other site 1306414006762 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1306414006763 RNA binding site [nucleotide binding]; other site 1306414006764 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1306414006765 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1306414006766 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1306414006767 active site 1306414006768 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1306414006769 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1306414006770 trimer interface [polypeptide binding]; other site 1306414006771 active site 1306414006772 dimer interface [polypeptide binding]; other site 1306414006773 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1306414006774 active site 1306414006775 dimer interface [polypeptide binding]; other site 1306414006776 metal binding site [ion binding]; metal-binding site 1306414006777 shikimate kinase; Reviewed; Region: aroK; PRK00131 1306414006778 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1306414006779 ADP binding site [chemical binding]; other site 1306414006780 magnesium binding site [ion binding]; other site 1306414006781 putative shikimate binding site; other site 1306414006782 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1306414006783 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1306414006784 Tetramer interface [polypeptide binding]; other site 1306414006785 active site 1306414006786 FMN-binding site [chemical binding]; other site 1306414006787 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1306414006788 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1306414006789 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1306414006790 putative active site [active] 1306414006791 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1306414006792 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1306414006793 oligomeric interface; other site 1306414006794 putative active site [active] 1306414006795 homodimer interface [polypeptide binding]; other site 1306414006796 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1306414006797 putative active site [active] 1306414006798 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1306414006799 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1306414006800 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1306414006801 shikimate-5-dehydrogenase, fungal AROM-type; Region: Shik-DH-AROM; TIGR01809 1306414006802 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1306414006803 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1306414006804 NAD(P) binding site [chemical binding]; other site 1306414006805 shikimate binding site; other site 1306414006806 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 1306414006807 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1306414006808 dimerization interface [polypeptide binding]; other site 1306414006809 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1306414006810 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1306414006811 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1306414006812 motif 1; other site 1306414006813 active site 1306414006814 motif 2; other site 1306414006815 motif 3; other site 1306414006816 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1306414006817 DHHA1 domain; Region: DHHA1; pfam02272 1306414006818 Uncharacterized conserved protein [Function unknown]; Region: COG0432 1306414006819 recombination factor protein RarA; Reviewed; Region: PRK13342 1306414006820 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1306414006821 Walker A motif; other site 1306414006822 ATP binding site [chemical binding]; other site 1306414006823 Walker B motif; other site 1306414006824 arginine finger; other site 1306414006825 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1306414006826 Predicted integral membrane protein [Function unknown]; Region: COG5473 1306414006827 Protein of unknown function (DUF2652); Region: DUF2652; pfam10851 1306414006828 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1306414006829 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1306414006830 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1306414006831 Walker A/P-loop; other site 1306414006832 ATP binding site [chemical binding]; other site 1306414006833 Q-loop/lid; other site 1306414006834 ABC transporter signature motif; other site 1306414006835 Walker B; other site 1306414006836 D-loop; other site 1306414006837 H-loop/switch region; other site 1306414006838 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1306414006839 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1306414006840 ligand binding site [chemical binding]; other site 1306414006841 flexible hinge region; other site 1306414006842 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1306414006843 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1306414006844 ligand binding site [chemical binding]; other site 1306414006845 flexible hinge region; other site 1306414006846 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1306414006847 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 1306414006848 active site 1306414006849 nucleophile elbow; other site 1306414006850 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1306414006851 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1306414006852 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1306414006853 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 1306414006854 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 1306414006855 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1306414006856 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1306414006857 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1306414006858 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 1306414006859 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 1306414006860 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1306414006861 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1306414006862 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1306414006863 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3801 1306414006864 Predicted membrane protein [Function unknown]; Region: COG4129 1306414006865 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1306414006866 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1306414006867 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1306414006868 dimer interface [polypeptide binding]; other site 1306414006869 anticodon binding site; other site 1306414006870 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1306414006871 homodimer interface [polypeptide binding]; other site 1306414006872 motif 1; other site 1306414006873 active site 1306414006874 motif 2; other site 1306414006875 GAD domain; Region: GAD; pfam02938 1306414006876 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1306414006877 active site 1306414006878 motif 3; other site 1306414006879 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1306414006880 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1306414006881 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1306414006882 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1306414006883 putative hydrophobic ligand binding site [chemical binding]; other site 1306414006884 protein interface [polypeptide binding]; other site 1306414006885 gate; other site 1306414006886 Predicted metalloprotease [General function prediction only]; Region: COG2321 1306414006887 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1306414006888 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1306414006889 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1306414006890 active site 1306414006891 metal binding site [ion binding]; metal-binding site 1306414006892 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1306414006893 haloalkane dehalogenase; Provisional; Region: PRK03592 1306414006894 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1306414006895 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1306414006896 dimer interface [polypeptide binding]; other site 1306414006897 motif 1; other site 1306414006898 active site 1306414006899 motif 2; other site 1306414006900 motif 3; other site 1306414006901 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1306414006902 anticodon binding site; other site 1306414006903 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1306414006904 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1306414006905 active site 1306414006906 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 1306414006907 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1306414006908 Zn2+ binding site [ion binding]; other site 1306414006909 Mg2+ binding site [ion binding]; other site 1306414006910 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1306414006911 synthetase active site [active] 1306414006912 NTP binding site [chemical binding]; other site 1306414006913 metal binding site [ion binding]; metal-binding site 1306414006914 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1306414006915 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1306414006916 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1306414006917 active site 1306414006918 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1306414006919 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1306414006920 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1306414006921 Protein export membrane protein; Region: SecD_SecF; pfam02355 1306414006922 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1306414006923 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1306414006924 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05886 1306414006925 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 1306414006926 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1306414006927 inhibitor-cofactor binding pocket; inhibition site 1306414006928 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1306414006929 catalytic residue [active] 1306414006930 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1306414006931 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1306414006932 acyl-activating enzyme (AAE) consensus motif; other site 1306414006933 AMP binding site [chemical binding]; other site 1306414006934 active site 1306414006935 CoA binding site [chemical binding]; other site 1306414006936 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 1306414006937 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1306414006938 putative NAD(P) binding site [chemical binding]; other site 1306414006939 active site 1306414006940 putative substrate binding site [chemical binding]; other site 1306414006941 PE family; Region: PE; pfam00934 1306414006942 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1306414006943 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1306414006944 Walker A motif; other site 1306414006945 ATP binding site [chemical binding]; other site 1306414006946 Walker B motif; other site 1306414006947 arginine finger; other site 1306414006948 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1306414006949 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1306414006950 RuvA N terminal domain; Region: RuvA_N; pfam01330 1306414006951 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1306414006952 active site 1306414006953 putative DNA-binding cleft [nucleotide binding]; other site 1306414006954 dimer interface [polypeptide binding]; other site 1306414006955 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1306414006956 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 1306414006957 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1306414006958 putative active site [active] 1306414006959 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 1306414006960 Protein of unknown function DUF2617; Region: DUF2617; pfam10936 1306414006961 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 1306414006962 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1306414006963 Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only]; Region: COG4262 1306414006964 Spermine/spermidine synthase; Region: Spermine_synth; pfam01564 1306414006965 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 1306414006966 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1306414006967 hypothetical protein; Validated; Region: PRK00110 1306414006968 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1306414006969 predicted active site [active] 1306414006970 catalytic triad [active] 1306414006971 acyl-CoA thioesterase II; Region: tesB; TIGR00189 1306414006972 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1306414006973 active site 1306414006974 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1306414006975 catalytic triad [active] 1306414006976 dimer interface [polypeptide binding]; other site 1306414006977 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1306414006978 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1306414006979 active site 1306414006980 multimer interface [polypeptide binding]; other site 1306414006981 Pyridoxamine-phosphate oxidase [Coenzyme metabolism]; Region: PdxH; COG0259 1306414006982 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1306414006983 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1306414006984 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306414006985 PPE family; Region: PPE; pfam00823 1306414006986 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306414006987 PE-PPE domain; Region: PE-PPE; pfam08237 1306414006988 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 1306414006989 nudix motif; other site 1306414006990 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1306414006991 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1306414006992 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1306414006993 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1306414006994 putative acyl-acceptor binding pocket; other site 1306414006995 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1306414006996 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 1306414006997 nucleotide binding site/active site [active] 1306414006998 HIT family signature motif; other site 1306414006999 catalytic residue [active] 1306414007000 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 1306414007001 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1306414007002 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1306414007003 active site 1306414007004 dimer interface [polypeptide binding]; other site 1306414007005 motif 1; other site 1306414007006 motif 2; other site 1306414007007 motif 3; other site 1306414007008 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1306414007009 anticodon binding site; other site 1306414007010 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1306414007011 phosphate binding site [ion binding]; other site 1306414007012 PE family; Region: PE; pfam00934 1306414007013 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4762 1306414007014 Helix-turn-helix domain; Region: HTH_20; pfam12840 1306414007015 Predicted transcriptional regulator [Transcription]; Region: COG2345 1306414007016 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1306414007017 Predicted transcriptional regulator [Transcription]; Region: COG2345 1306414007018 Helix-turn-helix domain; Region: HTH_20; pfam12840 1306414007019 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306414007020 S-adenosylmethionine binding site [chemical binding]; other site 1306414007021 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1306414007022 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1306414007023 Ligand Binding Site [chemical binding]; other site 1306414007024 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1306414007025 Ligand Binding Site [chemical binding]; other site 1306414007026 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1306414007027 Ligand Binding Site [chemical binding]; other site 1306414007028 Universal stress protein family; Region: Usp; pfam00582 1306414007029 Ligand Binding Site [chemical binding]; other site 1306414007030 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 1306414007031 active site 1306414007032 Peptidase family M50; Region: Peptidase_M50; pfam02163 1306414007033 putative substrate binding region [chemical binding]; other site 1306414007034 FOG: CBS domain [General function prediction only]; Region: COG0517 1306414007035 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 1306414007036 FOG: CBS domain [General function prediction only]; Region: COG0517 1306414007037 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1306414007038 peptide chain release factor 1; Provisional; Region: PRK04011 1306414007039 SHS2 domain protein implicated in nucleic acid metabolism [General function prediction only]; Region: COG1371 1306414007040 Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690 1306414007041 hypothetical protein; Reviewed; Region: PRK09588 1306414007042 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 1306414007043 Hemerythrin-like domain; Region: Hr-like; cd12108 1306414007044 Fe binding site [ion binding]; other site 1306414007045 PE family; Region: PE; pfam00934 1306414007046 Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cd00227 1306414007047 P-loop motif; other site 1306414007048 ATP binding site [chemical binding]; other site 1306414007049 Chloramphenicol (Cm) binding site [chemical binding]; other site 1306414007050 catalytic residue [active] 1306414007051 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1306414007052 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1306414007053 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1306414007054 anti sigma factor interaction site; other site 1306414007055 regulatory phosphorylation site [posttranslational modification]; other site 1306414007056 hypothetical protein; Provisional; Region: PRK02237 1306414007057 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1306414007058 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1306414007059 putative DNA binding site [nucleotide binding]; other site 1306414007060 putative Zn2+ binding site [ion binding]; other site 1306414007061 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 1306414007062 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1306414007063 putative metal binding site [ion binding]; other site 1306414007064 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1306414007065 dimerization interface [polypeptide binding]; other site 1306414007066 putative DNA binding site [nucleotide binding]; other site 1306414007067 putative Zn2+ binding site [ion binding]; other site 1306414007068 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1306414007069 arsenical-resistance protein; Region: acr3; TIGR00832 1306414007070 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1306414007071 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1306414007072 active site 1306414007073 Protein of unknown function (DUF3018); Region: DUF3018; pfam11455 1306414007074 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1306414007075 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1306414007076 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1306414007077 active site 1306414007078 DNA binding site [nucleotide binding] 1306414007079 Int/Topo IB signature motif; other site 1306414007080 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1306414007081 ParB-like nuclease domain; Region: ParBc; cl02129 1306414007082 Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653 1306414007083 Phage capsid family; Region: Phage_capsid; pfam05065 1306414007084 Phage head maturation protease [General function prediction only]; Region: COG3740 1306414007085 Phage terminase, small subunit; Region: Terminase_4; cl01525 1306414007086 Protein of unknown function (DUF3631); Region: DUF3631; pfam12307 1306414007087 Protein of unknown function (DUF2742); Region: DUF2742; pfam10888 1306414007088 DNA binding domain, excisionase family; Region: excise; TIGR01764 1306414007089 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1306414007090 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1306414007091 active site 1306414007092 catalytic residues [active] 1306414007093 DNA binding site [nucleotide binding] 1306414007094 Int/Topo IB signature motif; other site 1306414007095 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1306414007096 MULE transposase domain; Region: MULE; pfam10551 1306414007097 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1306414007098 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1306414007099 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1306414007100 Coenzyme A binding pocket [chemical binding]; other site 1306414007101 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 1306414007102 hypothetical protein; Provisional; Region: PRK14059 1306414007103 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1306414007104 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1306414007105 TAP-like protein; Region: Abhydrolase_4; pfam08386 1306414007106 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1306414007107 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 1306414007108 SelR domain; Region: SelR; pfam01641 1306414007109 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1306414007110 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306414007111 S-adenosylmethionine binding site [chemical binding]; other site 1306414007112 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 1306414007113 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1306414007114 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1306414007115 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1306414007116 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1306414007117 substrate binding site [chemical binding]; other site 1306414007118 active site 1306414007119 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1306414007120 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1306414007121 substrate binding site [chemical binding]; other site 1306414007122 oxyanion hole (OAH) forming residues; other site 1306414007123 trimer interface [polypeptide binding]; other site 1306414007124 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 1306414007125 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 1306414007126 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1306414007127 catalytic site [active] 1306414007128 putative active site [active] 1306414007129 putative substrate binding site [chemical binding]; other site 1306414007130 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 1306414007131 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1306414007132 TPP-binding site; other site 1306414007133 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1306414007134 PYR/PP interface [polypeptide binding]; other site 1306414007135 dimer interface [polypeptide binding]; other site 1306414007136 TPP binding site [chemical binding]; other site 1306414007137 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1306414007138 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1306414007139 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1306414007140 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 1306414007141 transmembrane helices; other site 1306414007142 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1306414007143 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 1306414007144 transmembrane helices; other site 1306414007145 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1306414007146 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1306414007147 Walker A/P-loop; other site 1306414007148 ATP binding site [chemical binding]; other site 1306414007149 Q-loop/lid; other site 1306414007150 ABC transporter signature motif; other site 1306414007151 Walker B; other site 1306414007152 D-loop; other site 1306414007153 H-loop/switch region; other site 1306414007154 TRAM domain; Region: TRAM; cl01282 1306414007155 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1306414007156 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1306414007157 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1306414007158 TrkA-N domain; Region: TrkA_N; pfam02254 1306414007159 TrkA-C domain; Region: TrkA_C; pfam02080 1306414007160 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1306414007161 TrkA-N domain; Region: TrkA_N; pfam02254 1306414007162 TrkA-C domain; Region: TrkA_C; pfam02080 1306414007163 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 1306414007164 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1306414007165 generic binding surface II; other site 1306414007166 ssDNA binding site; other site 1306414007167 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 1306414007168 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1306414007169 trimer interface [polypeptide binding]; other site 1306414007170 active site 1306414007171 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 1306414007172 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 1306414007173 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1306414007174 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1306414007175 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1306414007176 active site 1306414007177 dimerization interface [polypeptide binding]; other site 1306414007178 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1306414007179 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1306414007180 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1306414007181 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1306414007182 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1306414007183 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1306414007184 DNA binding residues [nucleotide binding] 1306414007185 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 1306414007186 homotrimer interaction site [polypeptide binding]; other site 1306414007187 putative active site [active] 1306414007188 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 1306414007189 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 1306414007190 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 1306414007191 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1306414007192 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1306414007193 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1306414007194 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1306414007195 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1306414007196 DNA binding residues [nucleotide binding] 1306414007197 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1306414007198 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1306414007199 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1306414007200 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 1306414007201 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 1306414007202 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 1306414007203 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1306414007204 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1306414007205 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1306414007206 PAC2 family; Region: PAC2; pfam09754 1306414007207 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1306414007208 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1306414007209 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1306414007210 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 1306414007211 heme-binding site [chemical binding]; other site 1306414007212 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1306414007213 ATP cone domain; Region: ATP-cone; pfam03477 1306414007214 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 1306414007215 LexA repressor; Validated; Region: PRK00215 1306414007216 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1306414007217 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1306414007218 Catalytic site [active] 1306414007219 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1306414007220 LGFP repeat; Region: LGFP; pfam08310 1306414007221 LGFP repeat; Region: LGFP; pfam08310 1306414007222 LGFP repeat; Region: LGFP; pfam08310 1306414007223 LGFP repeat; Region: LGFP; pfam08310 1306414007224 LGFP repeat; Region: LGFP; pfam08310 1306414007225 Integral membrane protein TerC family; Region: TerC; cl10468 1306414007226 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306414007227 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1306414007228 active site 1306414007229 GTPases [General function prediction only]; Region: HflX; COG2262 1306414007230 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1306414007231 HflX GTPase family; Region: HflX; cd01878 1306414007232 G1 box; other site 1306414007233 GTP/Mg2+ binding site [chemical binding]; other site 1306414007234 Switch I region; other site 1306414007235 G2 box; other site 1306414007236 G3 box; other site 1306414007237 Switch II region; other site 1306414007238 G4 box; other site 1306414007239 G5 box; other site 1306414007240 diaminopimelate epimerase; Region: DapF; TIGR00652 1306414007241 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1306414007242 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1306414007243 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1306414007244 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1306414007245 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 1306414007246 active site 1306414007247 metal binding site [ion binding]; metal-binding site 1306414007248 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1306414007249 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1306414007250 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1306414007251 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 1306414007252 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1306414007253 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1306414007254 FeS/SAM binding site; other site 1306414007255 TRAM domain; Region: TRAM; cl01282 1306414007256 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1306414007257 FeS/SAM binding site; other site 1306414007258 Uncharacterized protein conserved in bacteria [General function prediction only]; Region: OraA; COG2137 1306414007259 DNA recombination protein RecA; Reviewed; Region: recA; PRK09519 1306414007260 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1306414007261 hexamer interface [polypeptide binding]; other site 1306414007262 Walker A motif; other site 1306414007263 ATP binding site [chemical binding]; other site 1306414007264 Walker B motif; other site 1306414007265 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1306414007266 protein-splicing catalytic site; other site 1306414007267 thioester formation/cholesterol transfer; other site 1306414007268 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 1306414007269 recA bacterial DNA recombination protein; Region: RecA; cl17211 1306414007270 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 1306414007271 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 1306414007272 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1306414007273 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1306414007274 Limonene-1,2-epoxide hydrolase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LimA; COG4308 1306414007275 PE family; Region: PE; pfam00934 1306414007276 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 1306414007277 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1306414007278 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1306414007279 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1306414007280 non-specific DNA binding site [nucleotide binding]; other site 1306414007281 salt bridge; other site 1306414007282 sequence-specific DNA binding site [nucleotide binding]; other site 1306414007283 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1306414007284 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1306414007285 Coenzyme A binding pocket [chemical binding]; other site 1306414007286 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1306414007287 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1306414007288 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 1306414007289 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1306414007290 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 1306414007291 classical (c) SDRs; Region: SDR_c; cd05233 1306414007292 NAD(P) binding site [chemical binding]; other site 1306414007293 active site 1306414007294 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1306414007295 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1306414007296 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1306414007297 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1306414007298 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1306414007299 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1306414007300 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1306414007301 dimer interface [polypeptide binding]; other site 1306414007302 active site 1306414007303 catalytic residue [active] 1306414007304 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 1306414007305 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1306414007306 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1306414007307 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1306414007308 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1306414007309 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1306414007310 putative active site [active] 1306414007311 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1306414007312 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 1306414007313 putative active site [active] 1306414007314 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 1306414007315 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1306414007316 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1306414007317 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 1306414007318 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1306414007319 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1306414007320 folate binding site [chemical binding]; other site 1306414007321 NADP+ binding site [chemical binding]; other site 1306414007322 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1306414007323 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1306414007324 dimerization interface [polypeptide binding]; other site 1306414007325 active site 1306414007326 Dienelactone hydrolase family; Region: DLH; pfam01738 1306414007327 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1306414007328 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1306414007329 classical (c) SDRs; Region: SDR_c; cd05233 1306414007330 NAD(P) binding site [chemical binding]; other site 1306414007331 active site 1306414007332 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306414007333 PPE family; Region: PPE; pfam00823 1306414007334 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1306414007335 PE family; Region: PE; pfam00934 1306414007336 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1306414007337 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306414007338 PPE family; Region: PPE; pfam00823 1306414007339 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1306414007340 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1306414007341 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1306414007342 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1306414007343 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1306414007344 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1306414007345 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1306414007346 Coenzyme A binding pocket [chemical binding]; other site 1306414007347 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1306414007348 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1306414007349 FMN-binding pocket [chemical binding]; other site 1306414007350 flavin binding motif; other site 1306414007351 phosphate binding motif [ion binding]; other site 1306414007352 beta-alpha-beta structure motif; other site 1306414007353 NAD binding pocket [chemical binding]; other site 1306414007354 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1306414007355 catalytic loop [active] 1306414007356 iron binding site [ion binding]; other site 1306414007357 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1306414007358 hydrophobic ligand binding site; other site 1306414007359 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1306414007360 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1306414007361 putative DNA binding site [nucleotide binding]; other site 1306414007362 putative Zn2+ binding site [ion binding]; other site 1306414007363 AsnC family; Region: AsnC_trans_reg; pfam01037 1306414007364 alanine dehydrogenase; Region: alaDH; TIGR00518 1306414007365 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1306414007366 hexamer interface [polypeptide binding]; other site 1306414007367 ligand binding site [chemical binding]; other site 1306414007368 putative active site [active] 1306414007369 NAD(P) binding site [chemical binding]; other site 1306414007370 Nitronate monooxygenase; Region: NMO; pfam03060 1306414007371 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1306414007372 FMN binding site [chemical binding]; other site 1306414007373 substrate binding site [chemical binding]; other site 1306414007374 putative catalytic residue [active] 1306414007375 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1306414007376 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1306414007377 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1306414007378 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 1306414007379 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 1306414007380 oligomer interface [polypeptide binding]; other site 1306414007381 RNA binding site [nucleotide binding]; other site 1306414007382 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1306414007383 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1306414007384 RNase E interface [polypeptide binding]; other site 1306414007385 trimer interface [polypeptide binding]; other site 1306414007386 active site 1306414007387 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1306414007388 putative nucleic acid binding region [nucleotide binding]; other site 1306414007389 G-X-X-G motif; other site 1306414007390 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1306414007391 RNA binding site [nucleotide binding]; other site 1306414007392 domain interface; other site 1306414007393 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1306414007394 16S/18S rRNA binding site [nucleotide binding]; other site 1306414007395 S13e-L30e interaction site [polypeptide binding]; other site 1306414007396 25S rRNA binding site [nucleotide binding]; other site 1306414007397 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1306414007398 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1306414007399 active site 1306414007400 Riboflavin kinase; Region: Flavokinase; pfam01687 1306414007401 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1306414007402 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 1306414007403 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1306414007404 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1306414007405 putative DNA binding site [nucleotide binding]; other site 1306414007406 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1306414007407 FeoA domain; Region: FeoA; pfam04023 1306414007408 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306414007409 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1306414007410 active site 1306414007411 lipid-transfer protein; Provisional; Region: PRK08256 1306414007412 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1306414007413 active site 1306414007414 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1306414007415 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1306414007416 Probable transposase; Region: OrfB_IS605; pfam01385 1306414007417 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1306414007418 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 1306414007419 catalytic residues [active] 1306414007420 catalytic nucleophile [active] 1306414007421 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 1306414007422 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1306414007423 RNA binding site [nucleotide binding]; other site 1306414007424 active site 1306414007425 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 1306414007426 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 1306414007427 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1306414007428 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1306414007429 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1306414007430 active site 1306414007431 metal binding site [ion binding]; metal-binding site 1306414007432 Uncharacterized conserved protein [Function unknown]; Region: COG4717 1306414007433 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1306414007434 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1306414007435 Predicted acyl esterases [General function prediction only]; Region: COG2936 1306414007436 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1306414007437 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1306414007438 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 1306414007439 Uncharacterized conserved protein [Function unknown]; Region: COG5586 1306414007440 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 1306414007441 Integrase core domain; Region: rve; pfam00665 1306414007442 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1306414007443 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1306414007444 Helix-turn-helix domain; Region: HTH_28; pfam13518 1306414007445 Winged helix-turn helix; Region: HTH_29; pfam13551 1306414007446 Integrase core domain; Region: rve; pfam00665 1306414007447 Integrase core domain; Region: rve_3; cl15866 1306414007448 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 1306414007449 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 1306414007450 putative transposase OrfB; Reviewed; Region: PHA02517 1306414007451 HTH-like domain; Region: HTH_21; pfam13276 1306414007452 Integrase core domain; Region: rve; pfam00665 1306414007453 Integrase core domain; Region: rve_3; pfam13683 1306414007454 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1306414007455 Transposase; Region: HTH_Tnp_1; cl17663 1306414007456 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 1306414007457 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09636 1306414007458 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cd09699 1306414007459 CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cd09662 1306414007460 CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cd09663 1306414007461 CRISPR/Cas system-associated RAMP superfamily protein Csm3; Region: Csm3_III-A; cd09684 1306414007462 CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cd09647 1306414007463 Predicted CRISPR-associated polymerase [Defense mechanisms]; Region: COG1353 1306414007464 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 1306414007465 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 1306414007466 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4293 1306414007467 Uncharacterized conserved protein [Function unknown]; Region: COG2253 1306414007468 Protein of unknown function (DUF2005); Region: DUF2005; pfam09407 1306414007469 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4293 1306414007470 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 1306414007471 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 1306414007472 putative active site [active] 1306414007473 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1306414007474 enoyl-CoA hydratase; Provisional; Region: PRK06190 1306414007475 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1306414007476 substrate binding site [chemical binding]; other site 1306414007477 oxyanion hole (OAH) forming residues; other site 1306414007478 trimer interface [polypeptide binding]; other site 1306414007479 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1306414007480 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1306414007481 Walker A/P-loop; other site 1306414007482 ATP binding site [chemical binding]; other site 1306414007483 Q-loop/lid; other site 1306414007484 ABC transporter signature motif; other site 1306414007485 Walker B; other site 1306414007486 D-loop; other site 1306414007487 H-loop/switch region; other site 1306414007488 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1306414007489 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1306414007490 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1306414007491 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1306414007492 dimer interface [polypeptide binding]; other site 1306414007493 conserved gate region; other site 1306414007494 putative PBP binding loops; other site 1306414007495 ABC-ATPase subunit interface; other site 1306414007496 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1306414007497 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1306414007498 dimer interface [polypeptide binding]; other site 1306414007499 conserved gate region; other site 1306414007500 putative PBP binding loops; other site 1306414007501 ABC-ATPase subunit interface; other site 1306414007502 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1306414007503 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1306414007504 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1306414007505 DHH family; Region: DHH; pfam01368 1306414007506 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1306414007507 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1306414007508 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1306414007509 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 1306414007510 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1306414007511 G1 box; other site 1306414007512 putative GEF interaction site [polypeptide binding]; other site 1306414007513 GTP/Mg2+ binding site [chemical binding]; other site 1306414007514 Switch I region; other site 1306414007515 G2 box; other site 1306414007516 G3 box; other site 1306414007517 Switch II region; other site 1306414007518 G4 box; other site 1306414007519 G5 box; other site 1306414007520 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1306414007521 Translation-initiation factor 2; Region: IF-2; pfam11987 1306414007522 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1306414007523 Predicted nucleic-acid-binding protein implicated in transcription termination [Transcription]; Region: COG2740 1306414007524 putative RNA binding cleft [nucleotide binding]; other site 1306414007525 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1306414007526 NusA N-terminal domain; Region: NusA_N; pfam08529 1306414007527 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1306414007528 RNA binding site [nucleotide binding]; other site 1306414007529 homodimer interface [polypeptide binding]; other site 1306414007530 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1306414007531 G-X-X-G motif; other site 1306414007532 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1306414007533 G-X-X-G motif; other site 1306414007534 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1306414007535 Sm and related proteins; Region: Sm_like; cl00259 1306414007536 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1306414007537 putative oligomer interface [polypeptide binding]; other site 1306414007538 putative RNA binding site [nucleotide binding]; other site 1306414007539 Mitochondrial ATP synthase g subunit; Region: ATP-synt_G; pfam04718 1306414007540 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1306414007541 dinuclear metal binding motif [ion binding]; other site 1306414007542 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1306414007543 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1306414007544 dimer interface [polypeptide binding]; other site 1306414007545 motif 1; other site 1306414007546 active site 1306414007547 motif 2; other site 1306414007548 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 1306414007549 putative deacylase active site [active] 1306414007550 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1306414007551 active site 1306414007552 motif 3; other site 1306414007553 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1306414007554 anticodon binding site; other site 1306414007555 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1306414007556 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1306414007557 putative substrate translocation pore; other site 1306414007558 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 1306414007559 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1306414007560 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1306414007561 homodimer interface [polypeptide binding]; other site 1306414007562 active site 1306414007563 SAM binding site [chemical binding]; other site 1306414007564 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1306414007565 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1306414007566 homodimer interface [polypeptide binding]; other site 1306414007567 Walker A motif; other site 1306414007568 ATP binding site [chemical binding]; other site 1306414007569 hydroxycobalamin binding site [chemical binding]; other site 1306414007570 Walker B motif; other site 1306414007571 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 1306414007572 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1306414007573 Walker A motif; other site 1306414007574 ATP binding site [chemical binding]; other site 1306414007575 Walker B motif; other site 1306414007576 arginine finger; other site 1306414007577 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 1306414007578 metal ion-dependent adhesion site (MIDAS); other site 1306414007579 Predicted acyltransferase [General function prediction only]; Region: ElaA; COG2153 1306414007580 malate:quinone oxidoreductase; Validated; Region: PRK05257 1306414007581 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1306414007582 PE family; Region: PE; pfam00934 1306414007583 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1306414007584 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1306414007585 mycothione reductase; Reviewed; Region: PRK07846 1306414007586 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1306414007587 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1306414007588 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1306414007589 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 1306414007590 short chain dehydrogenase; Provisional; Region: PRK06057 1306414007591 classical (c) SDRs; Region: SDR_c; cd05233 1306414007592 NAD(P) binding site [chemical binding]; other site 1306414007593 active site 1306414007594 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1306414007595 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 1306414007596 NAD(P) binding site [chemical binding]; other site 1306414007597 catalytic residues [active] 1306414007598 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 1306414007599 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1306414007600 catalytic triad [active] 1306414007601 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1306414007602 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1306414007603 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1306414007604 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1306414007605 active site 1306414007606 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1306414007607 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1306414007608 putative active site [active] 1306414007609 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1306414007610 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1306414007611 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1306414007612 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 1306414007613 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1306414007614 Predicted acetyltransferase [General function prediction only]; Region: COG3393 1306414007615 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 1306414007616 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1306414007617 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1306414007618 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1306414007619 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 1306414007620 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1306414007621 active site 1306414007622 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1306414007623 protein binding site [polypeptide binding]; other site 1306414007624 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1306414007625 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1306414007626 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1306414007627 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1306414007628 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1306414007629 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1306414007630 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 1306414007631 Fasciclin domain; Region: Fasciclin; pfam02469 1306414007632 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1306414007633 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1306414007634 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 1306414007635 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1306414007636 catalytic residues [active] 1306414007637 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 1306414007638 Fasciclin domain; Region: Fasciclin; pfam02469 1306414007639 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 1306414007640 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1306414007641 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 1306414007642 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1306414007643 catalytic residues [active] 1306414007644 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 1306414007645 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1306414007646 FeS/SAM binding site; other site 1306414007647 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1306414007648 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1306414007649 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1306414007650 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1306414007651 hinge region; other site 1306414007652 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1306414007653 putative nucleotide binding site [chemical binding]; other site 1306414007654 uridine monophosphate binding site [chemical binding]; other site 1306414007655 homohexameric interface [polypeptide binding]; other site 1306414007656 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1306414007657 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1306414007658 DNA binding site [nucleotide binding] 1306414007659 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1306414007660 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1306414007661 Probable transposase; Region: OrfB_IS605; pfam01385 1306414007662 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1306414007663 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 1306414007664 catalytic residues [active] 1306414007665 catalytic nucleophile [active] 1306414007666 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1306414007667 MarR family; Region: MarR; pfam01047 1306414007668 amidase; Provisional; Region: PRK07869 1306414007669 Amidase; Region: Amidase; pfam01425 1306414007670 elongation factor Ts; Provisional; Region: tsf; PRK09377 1306414007671 UBA/TS-N domain; Region: UBA; pfam00627 1306414007672 Elongation factor TS; Region: EF_TS; pfam00889 1306414007673 Elongation factor TS; Region: EF_TS; pfam00889 1306414007674 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1306414007675 rRNA interaction site [nucleotide binding]; other site 1306414007676 S8 interaction site; other site 1306414007677 putative laminin-1 binding site; other site 1306414007678 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306414007679 PPE family; Region: PPE; pfam00823 1306414007680 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1306414007681 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 1306414007682 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1306414007683 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1306414007684 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1306414007685 active site 1306414007686 DNA binding site [nucleotide binding] 1306414007687 Int/Topo IB signature motif; other site 1306414007688 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1306414007689 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1306414007690 FAD binding pocket [chemical binding]; other site 1306414007691 FAD binding motif [chemical binding]; other site 1306414007692 phosphate binding motif [ion binding]; other site 1306414007693 NAD binding pocket [chemical binding]; other site 1306414007694 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 1306414007695 DNA protecting protein DprA; Region: dprA; TIGR00732 1306414007696 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1306414007697 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1306414007698 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1306414007699 Walker A motif; other site 1306414007700 ATP binding site [chemical binding]; other site 1306414007701 Walker B motif; other site 1306414007702 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1306414007703 hypothetical protein; Reviewed; Region: PRK12497 1306414007704 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1306414007705 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 1306414007706 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 1306414007707 putative molybdopterin cofactor binding site [chemical binding]; other site 1306414007708 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 1306414007709 putative molybdopterin cofactor binding site; other site 1306414007710 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 1306414007711 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1306414007712 RNA/DNA hybrid binding site [nucleotide binding]; other site 1306414007713 active site 1306414007714 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1306414007715 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1306414007716 Catalytic site [active] 1306414007717 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1306414007718 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1306414007719 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1306414007720 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1306414007721 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1306414007722 RimM N-terminal domain; Region: RimM; pfam01782 1306414007723 hypothetical protein; Provisional; Region: PRK02821 1306414007724 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1306414007725 G-X-X-G motif; other site 1306414007726 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 1306414007727 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1306414007728 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1306414007729 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1306414007730 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306414007731 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306414007732 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1306414007733 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 1306414007734 active site 1306414007735 putative substrate binding pocket [chemical binding]; other site 1306414007736 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1306414007737 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1306414007738 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1306414007739 active site 1306414007740 ATP binding site [chemical binding]; other site 1306414007741 substrate binding site [chemical binding]; other site 1306414007742 activation loop (A-loop); other site 1306414007743 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1306414007744 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 1306414007745 active site 1306414007746 signal recognition particle protein; Provisional; Region: PRK10867 1306414007747 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1306414007748 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1306414007749 P loop; other site 1306414007750 GTP binding site [chemical binding]; other site 1306414007751 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1306414007752 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1306414007753 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1306414007754 ATP binding site [chemical binding]; other site 1306414007755 putative Mg++ binding site [ion binding]; other site 1306414007756 PII uridylyl-transferase; Provisional; Region: PRK03381 1306414007757 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1306414007758 metal binding triad; other site 1306414007759 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1306414007760 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1306414007761 Zn2+ binding site [ion binding]; other site 1306414007762 Mg2+ binding site [ion binding]; other site 1306414007763 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1306414007764 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1306414007765 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1306414007766 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 1306414007767 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1306414007768 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1306414007769 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1306414007770 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1306414007771 Walker A/P-loop; other site 1306414007772 ATP binding site [chemical binding]; other site 1306414007773 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1306414007774 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1306414007775 ABC transporter signature motif; other site 1306414007776 Walker B; other site 1306414007777 D-loop; other site 1306414007778 H-loop/switch region; other site 1306414007779 acylphosphatase; Provisional; Region: PRK14422 1306414007780 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 1306414007781 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1306414007782 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1306414007783 DNA binding site [nucleotide binding] 1306414007784 catalytic residue [active] 1306414007785 H2TH interface [polypeptide binding]; other site 1306414007786 putative catalytic residues [active] 1306414007787 turnover-facilitating residue; other site 1306414007788 intercalation triad [nucleotide binding]; other site 1306414007789 8OG recognition residue [nucleotide binding]; other site 1306414007790 putative reading head residues; other site 1306414007791 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1306414007792 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1306414007793 ribonuclease III; Reviewed; Region: rnc; PRK00102 1306414007794 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1306414007795 dimerization interface [polypeptide binding]; other site 1306414007796 active site 1306414007797 metal binding site [ion binding]; metal-binding site 1306414007798 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1306414007799 dsRNA binding site [nucleotide binding]; other site 1306414007800 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 1306414007801 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1306414007802 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1306414007803 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1306414007804 acyl-CoA synthetase; Validated; Region: PRK05850 1306414007805 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1306414007806 acyl-activating enzyme (AAE) consensus motif; other site 1306414007807 active site 1306414007808 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1306414007809 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1306414007810 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1306414007811 active site 1306414007812 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 1306414007813 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1306414007814 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 1306414007815 NADP binding site [chemical binding]; other site 1306414007816 KR domain; Region: KR; pfam08659 1306414007817 active site 1306414007818 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1306414007819 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1306414007820 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1306414007821 active site 1306414007822 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1306414007823 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 1306414007824 KR domain; Region: KR; pfam08659 1306414007825 NADP binding site [chemical binding]; other site 1306414007826 active site 1306414007827 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1306414007828 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1306414007829 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1306414007830 active site 1306414007831 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1306414007832 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1306414007833 Condensation domain; Region: Condensation; pfam00668 1306414007834 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1306414007835 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1306414007836 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1306414007837 Walker A/P-loop; other site 1306414007838 ATP binding site [chemical binding]; other site 1306414007839 Q-loop/lid; other site 1306414007840 ABC transporter signature motif; other site 1306414007841 Walker B; other site 1306414007842 D-loop; other site 1306414007843 H-loop/switch region; other site 1306414007844 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1306414007845 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 1306414007846 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 1306414007847 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1306414007848 acyltransferase PapA5; Provisional; Region: PRK09294 1306414007849 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1306414007850 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1306414007851 active site 1306414007852 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 1306414007853 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1306414007854 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1306414007855 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1306414007856 Enoylreductase; Region: PKS_ER; smart00829 1306414007857 NAD(P) binding site [chemical binding]; other site 1306414007858 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1306414007859 KR domain; Region: KR; pfam08659 1306414007860 putative NADP binding site [chemical binding]; other site 1306414007861 active site 1306414007862 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1306414007863 acyl-CoA synthetase; Validated; Region: PRK05850 1306414007864 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1306414007865 acyl-activating enzyme (AAE) consensus motif; other site 1306414007866 active site 1306414007867 MMPL family; Region: MMPL; pfam03176 1306414007868 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1306414007869 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1306414007870 Integrase core domain; Region: rve; pfam00665 1306414007871 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 1306414007872 acyl-CoA synthetase; Validated; Region: PRK06060 1306414007873 Benzoate CoA ligase (BCL) and similar adenylate forming enzymes; Region: BCL_like; cd05919 1306414007874 dimer interface [polypeptide binding]; other site 1306414007875 acyl-activating enzyme (AAE) consensus motif; other site 1306414007876 putative active site [active] 1306414007877 putative AMP binding site [chemical binding]; other site 1306414007878 putative CoA binding site [chemical binding]; other site 1306414007879 chemical substrate binding site [chemical binding]; other site 1306414007880 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1306414007881 4-hydroxybenzoate synthetase (chorismate lyase) [Coenzyme metabolism]; Region: UbiC; COG3161 1306414007882 acyl-CoA synthetase; Validated; Region: PRK05850 1306414007883 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1306414007884 acyl-activating enzyme (AAE) consensus motif; other site 1306414007885 active site 1306414007886 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1306414007887 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1306414007888 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306414007889 S-adenosylmethionine binding site [chemical binding]; other site 1306414007890 Uncharacterized conserved protein [Function unknown]; Region: COG3268 1306414007891 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1306414007892 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306414007893 S-adenosylmethionine binding site [chemical binding]; other site 1306414007894 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1306414007895 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1306414007896 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 1306414007897 metal-binding site 1306414007898 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1306414007899 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1306414007900 active site 1306414007901 TDP-binding site; other site 1306414007902 acceptor substrate-binding pocket; other site 1306414007903 Cephalosporin hydroxylase [Defense mechanisms]; Region: CmcI; COG3510 1306414007904 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1306414007905 Predicted permease; Region: DUF318; pfam03773 1306414007906 formyltetrahydrofolate deformylase; Region: PurU; TIGR00655 1306414007907 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1306414007908 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1306414007909 putative active site [active] 1306414007910 putative substrate binding site [chemical binding]; other site 1306414007911 putative cosubstrate binding site; other site 1306414007912 catalytic site [active] 1306414007913 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1306414007914 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1306414007915 active site 1306414007916 (T/H)XGH motif; other site 1306414007917 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1306414007918 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306414007919 S-adenosylmethionine binding site [chemical binding]; other site 1306414007920 pyruvate carboxylase; Reviewed; Region: PRK12999 1306414007921 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1306414007922 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1306414007923 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1306414007924 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1306414007925 active site 1306414007926 catalytic residues [active] 1306414007927 metal binding site [ion binding]; metal-binding site 1306414007928 homodimer binding site [polypeptide binding]; other site 1306414007929 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1306414007930 carboxyltransferase (CT) interaction site; other site 1306414007931 biotinylation site [posttranslational modification]; other site 1306414007932 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 1306414007933 putative active site [active] 1306414007934 redox center [active] 1306414007935 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1306414007936 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 1306414007937 catalytic residues [active] 1306414007938 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1306414007939 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1306414007940 substrate binding pocket [chemical binding]; other site 1306414007941 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1306414007942 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1306414007943 active site 1306414007944 catalytic tetrad [active] 1306414007945 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1306414007946 RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200 1306414007947 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1306414007948 generic binding surface II; other site 1306414007949 ssDNA binding site; other site 1306414007950 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1306414007951 ATP binding site [chemical binding]; other site 1306414007952 putative Mg++ binding site [ion binding]; other site 1306414007953 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1306414007954 nucleotide binding region [chemical binding]; other site 1306414007955 ATP-binding site [chemical binding]; other site 1306414007956 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1306414007957 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1306414007958 ligand binding site [chemical binding]; other site 1306414007959 active site 1306414007960 UGI interface [polypeptide binding]; other site 1306414007961 catalytic site [active] 1306414007962 thiamine monophosphate kinase; Provisional; Region: PRK05731 1306414007963 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1306414007964 ATP binding site [chemical binding]; other site 1306414007965 dimerization interface [polypeptide binding]; other site 1306414007966 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1306414007967 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1306414007968 Probable transposase; Region: OrfB_IS605; pfam01385 1306414007969 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1306414007970 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 1306414007971 catalytic residues [active] 1306414007972 catalytic nucleophile [active] 1306414007973 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 1306414007974 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1306414007975 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1306414007976 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1306414007977 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1306414007978 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1306414007979 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1306414007980 Predicted nucleotidyltransferase, CobY/MobA/RfbA family [General function prediction only]; Region: COG1920 1306414007981 polyphosphate kinase; Provisional; Region: PRK05443 1306414007982 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1306414007983 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1306414007984 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1306414007985 putative domain interface [polypeptide binding]; other site 1306414007986 putative active site [active] 1306414007987 catalytic site [active] 1306414007988 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1306414007989 putative domain interface [polypeptide binding]; other site 1306414007990 putative active site [active] 1306414007991 catalytic site [active] 1306414007992 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1306414007993 active site 1306414007994 Ap6A binding site [chemical binding]; other site 1306414007995 nudix motif; other site 1306414007996 metal binding site [ion binding]; metal-binding site 1306414007997 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1306414007998 catalytic core [active] 1306414007999 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1306414008000 IHF - DNA interface [nucleotide binding]; other site 1306414008001 IHF dimer interface [polypeptide binding]; other site 1306414008002 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1306414008003 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1306414008004 substrate binding site [chemical binding]; other site 1306414008005 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1306414008006 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1306414008007 substrate binding site [chemical binding]; other site 1306414008008 ligand binding site [chemical binding]; other site 1306414008009 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1306414008010 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1306414008011 Bacterial transcriptional regulator; Region: IclR; pfam01614 1306414008012 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306414008013 S-adenosylmethionine binding site [chemical binding]; other site 1306414008014 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 1306414008015 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1306414008016 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1306414008017 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1306414008018 active site 1306414008019 HIGH motif; other site 1306414008020 nucleotide binding site [chemical binding]; other site 1306414008021 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1306414008022 active site 1306414008023 KMSKS motif; other site 1306414008024 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1306414008025 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1306414008026 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1306414008027 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1306414008028 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1306414008029 ligand binding site [chemical binding]; other site 1306414008030 NAD binding site [chemical binding]; other site 1306414008031 dimerization interface [polypeptide binding]; other site 1306414008032 catalytic site [active] 1306414008033 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1306414008034 putative L-serine binding site [chemical binding]; other site 1306414008035 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1306414008036 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1306414008037 Protein of unknown function (DUF433); Region: DUF433; pfam04255 1306414008038 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 1306414008039 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 1306414008040 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 1306414008041 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1306414008042 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1306414008043 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1306414008044 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1306414008045 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1306414008046 putative valine binding site [chemical binding]; other site 1306414008047 dimer interface [polypeptide binding]; other site 1306414008048 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1306414008049 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 1306414008050 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1306414008051 PYR/PP interface [polypeptide binding]; other site 1306414008052 dimer interface [polypeptide binding]; other site 1306414008053 TPP binding site [chemical binding]; other site 1306414008054 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1306414008055 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1306414008056 TPP-binding site [chemical binding]; other site 1306414008057 dimer interface [polypeptide binding]; other site 1306414008058 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1306414008059 Predicted membrane protein [Function unknown]; Region: COG2259 1306414008060 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 1306414008061 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1306414008062 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1306414008063 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1306414008064 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1306414008065 GatB domain; Region: GatB_Yqey; smart00845 1306414008066 6-phosphofructokinase; Provisional; Region: PRK03202 1306414008067 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1306414008068 active site 1306414008069 ADP/pyrophosphate binding site [chemical binding]; other site 1306414008070 dimerization interface [polypeptide binding]; other site 1306414008071 allosteric effector site; other site 1306414008072 fructose-1,6-bisphosphate binding site; other site 1306414008073 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1306414008074 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1306414008075 aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, C subunit; Region: gatC; TIGR00135 1306414008076 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 1306414008077 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1306414008078 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1306414008079 nucleotide binding pocket [chemical binding]; other site 1306414008080 K-X-D-G motif; other site 1306414008081 catalytic site [active] 1306414008082 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1306414008083 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1306414008084 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1306414008085 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1306414008086 Dimer interface [polypeptide binding]; other site 1306414008087 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 1306414008088 PknH-like extracellular domain; Region: PknH_C; pfam14032 1306414008089 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1306414008090 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306414008091 PPE family; Region: PPE; pfam00823 1306414008092 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1306414008093 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1306414008094 MULE transposase domain; Region: MULE; pfam10551 1306414008095 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1306414008096 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1306414008097 Ligand Binding Site [chemical binding]; other site 1306414008098 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1306414008099 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1306414008100 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1306414008101 catalytic residue [active] 1306414008102 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1306414008103 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1306414008104 putative acyl-acceptor binding pocket; other site 1306414008105 Putative hemolysin [General function prediction only]; Region: COG3176 1306414008106 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1306414008107 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1306414008108 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1306414008109 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1306414008110 Ligand binding site [chemical binding]; other site 1306414008111 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1306414008112 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306414008113 S-adenosylmethionine binding site [chemical binding]; other site 1306414008114 Uncharacterized conserved protein [Function unknown]; Region: COG1543 1306414008115 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1306414008116 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 1306414008117 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1306414008118 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1306414008119 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 1306414008120 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 1306414008121 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1306414008122 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1306414008123 trimer interface [polypeptide binding]; other site 1306414008124 active site 1306414008125 substrate binding site [chemical binding]; other site 1306414008126 CoA binding site [chemical binding]; other site 1306414008127 FOG: WD40-like repeat [Function unknown]; Region: COG1520 1306414008128 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1306414008129 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306414008130 S-adenosylmethionine binding site [chemical binding]; other site 1306414008131 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1306414008132 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1306414008133 substrate binding site [chemical binding]; other site 1306414008134 oxyanion hole (OAH) forming residues; other site 1306414008135 trimer interface [polypeptide binding]; other site 1306414008136 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 1306414008137 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1306414008138 Walker A/P-loop; other site 1306414008139 ATP binding site [chemical binding]; other site 1306414008140 Q-loop/lid; other site 1306414008141 ABC transporter signature motif; other site 1306414008142 Walker B; other site 1306414008143 D-loop; other site 1306414008144 H-loop/switch region; other site 1306414008145 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 1306414008146 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 1306414008147 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1306414008148 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1306414008149 motif II; other site 1306414008150 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1306414008151 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1306414008152 D-pathway; other site 1306414008153 Putative ubiquinol binding site [chemical binding]; other site 1306414008154 Low-spin heme (heme b) binding site [chemical binding]; other site 1306414008155 Putative water exit pathway; other site 1306414008156 Binuclear center (heme o3/CuB) [ion binding]; other site 1306414008157 K-pathway; other site 1306414008158 Putative proton exit pathway; other site 1306414008159 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1306414008160 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1306414008161 siderophore binding site; other site 1306414008162 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1306414008163 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1306414008164 putative NAD(P) binding site [chemical binding]; other site 1306414008165 putative substrate binding site [chemical binding]; other site 1306414008166 catalytic Zn binding site [ion binding]; other site 1306414008167 structural Zn binding site [ion binding]; other site 1306414008168 dimer interface [polypeptide binding]; other site 1306414008169 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 1306414008170 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1306414008171 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1306414008172 dimer interface [polypeptide binding]; other site 1306414008173 putative radical transfer pathway; other site 1306414008174 diiron center [ion binding]; other site 1306414008175 tyrosyl radical; other site 1306414008176 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1306414008177 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1306414008178 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306414008179 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306414008180 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 1306414008181 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1306414008182 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1306414008183 active site 1306414008184 dimer interface [polypeptide binding]; other site 1306414008185 catalytic residues [active] 1306414008186 effector binding site; other site 1306414008187 R2 peptide binding site; other site 1306414008188 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1306414008189 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1306414008190 catalytic residues [active] 1306414008191 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1306414008192 Predicted flavoprotein [General function prediction only]; Region: COG0431 1306414008193 DNA polymerase IV; Validated; Region: PRK03352 1306414008194 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1306414008195 active site 1306414008196 DNA binding site [nucleotide binding] 1306414008197 short chain dehydrogenase; Provisional; Region: PRK07832 1306414008198 classical (c) SDRs; Region: SDR_c; cd05233 1306414008199 NAD(P) binding site [chemical binding]; other site 1306414008200 active site 1306414008201 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306414008202 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306414008203 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1306414008204 Cytochrome P450; Region: p450; cl12078 1306414008205 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1306414008206 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1306414008207 DNA-binding site [nucleotide binding]; DNA binding site 1306414008208 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1306414008209 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1306414008210 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1306414008211 DNA-binding site [nucleotide binding]; DNA binding site 1306414008212 FCD domain; Region: FCD; pfam07729 1306414008213 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306414008214 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1306414008215 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1306414008216 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306414008217 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306414008218 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1306414008219 active site 1306414008220 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 1306414008221 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 1306414008222 active site 1306414008223 DNA binding site [nucleotide binding] 1306414008224 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 1306414008225 DNA binding site [nucleotide binding] 1306414008226 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 1306414008227 Carbon starvation protein CstA; Region: CstA; pfam02554 1306414008228 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1306414008229 Predicted membrane protein [Function unknown]; Region: COG2259 1306414008230 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 1306414008231 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1306414008232 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306414008233 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1306414008234 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 1306414008235 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1306414008236 active site 1306414008237 substrate binding site [chemical binding]; other site 1306414008238 metal binding site [ion binding]; metal-binding site 1306414008239 camphor resistance protein CrcB; Provisional; Region: PRK14216 1306414008240 camphor resistance protein CrcB; Provisional; Region: PRK14228 1306414008241 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 1306414008242 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 1306414008243 Uncharacterized ACR, COG1993; Region: DUF190; pfam02641 1306414008244 Uncharacterized conserved protein [Function unknown]; Region: COG3189 1306414008245 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1306414008246 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1306414008247 active site 1306414008248 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1306414008249 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1306414008250 putative hydrophobic ligand binding site [chemical binding]; other site 1306414008251 protein interface [polypeptide binding]; other site 1306414008252 gate; other site 1306414008253 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1306414008254 Sulfatase; Region: Sulfatase; pfam00884 1306414008255 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1306414008256 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1306414008257 active site 1306414008258 ATP binding site [chemical binding]; other site 1306414008259 substrate binding site [chemical binding]; other site 1306414008260 activation loop (A-loop); other site 1306414008261 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 1306414008262 AAA ATPase domain; Region: AAA_16; pfam13191 1306414008263 Nucleotidyl transferase of unknown function (DUF2204); Region: DUF2204; pfam09970 1306414008264 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1306414008265 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1306414008266 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1306414008267 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1306414008268 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1306414008269 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1306414008270 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1306414008271 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1306414008272 NAD(P) binding site [chemical binding]; other site 1306414008273 active site 1306414008274 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1306414008275 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1306414008276 NAD binding site [chemical binding]; other site 1306414008277 catalytic Zn binding site [ion binding]; other site 1306414008278 substrate binding site [chemical binding]; other site 1306414008279 structural Zn binding site [ion binding]; other site 1306414008280 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1306414008281 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1306414008282 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1306414008283 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1306414008284 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 1306414008285 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1306414008286 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1306414008287 acyl-activating enzyme (AAE) consensus motif; other site 1306414008288 AMP binding site [chemical binding]; other site 1306414008289 active site 1306414008290 CoA binding site [chemical binding]; other site 1306414008291 SPFH domain / Band 7 family; Region: Band_7; pfam01145 1306414008292 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1306414008293 Patatin-like phospholipase; Region: Patatin; pfam01734 1306414008294 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 1306414008295 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 1306414008296 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1306414008297 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306414008298 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1306414008299 active site 1306414008300 Predicted transcriptional regulators [Transcription]; Region: COG1733 1306414008301 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1306414008302 dimerization interface [polypeptide binding]; other site 1306414008303 putative DNA binding site [nucleotide binding]; other site 1306414008304 putative Zn2+ binding site [ion binding]; other site 1306414008305 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 1306414008306 PE family; Region: PE; pfam00934 1306414008307 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1306414008308 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1306414008309 De-etiolated protein 1 Det1; Region: Det1; pfam09737 1306414008310 PemK-like protein; Region: PemK; pfam02452 1306414008311 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1306414008312 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1306414008313 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1306414008314 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1306414008315 SmpB-tmRNA interface; other site 1306414008316 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1306414008317 FtsX-like permease family; Region: FtsX; pfam02687 1306414008318 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1306414008319 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1306414008320 Walker A/P-loop; other site 1306414008321 ATP binding site [chemical binding]; other site 1306414008322 Q-loop/lid; other site 1306414008323 ABC transporter signature motif; other site 1306414008324 Walker B; other site 1306414008325 D-loop; other site 1306414008326 H-loop/switch region; other site 1306414008327 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1306414008328 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1306414008329 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1306414008330 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1306414008331 RF-1 domain; Region: RF-1; pfam00472 1306414008332 ferredoxin-NADP+ reductase; Region: PLN02852 1306414008333 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1306414008334 FAD binding domain; Region: FAD_binding_4; pfam01565 1306414008335 Molybdenum cofactor biosynthesis enzyme [Coenzyme metabolism]; Region: MoaA; COG2896 1306414008336 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1306414008337 FeS/SAM binding site; other site 1306414008338 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1306414008339 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 1306414008340 aromatic arch; other site 1306414008341 DCoH dimer interaction site [polypeptide binding]; other site 1306414008342 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1306414008343 DCoH tetramer interaction site [polypeptide binding]; other site 1306414008344 substrate binding site [chemical binding]; other site 1306414008345 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1306414008346 trimer interface [polypeptide binding]; other site 1306414008347 dimer interface [polypeptide binding]; other site 1306414008348 putative active site [active] 1306414008349 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1306414008350 MoaE interaction surface [polypeptide binding]; other site 1306414008351 MoeB interaction surface [polypeptide binding]; other site 1306414008352 thiocarboxylated glycine; other site 1306414008353 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1306414008354 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1306414008355 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1306414008356 nucleoside/Zn binding site; other site 1306414008357 dimer interface [polypeptide binding]; other site 1306414008358 catalytic motif [active] 1306414008359 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1306414008360 MULE transposase domain; Region: MULE; pfam10551 1306414008361 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1306414008362 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1306414008363 active site residue [active] 1306414008364 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1306414008365 active site residue [active] 1306414008366 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 1306414008367 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1306414008368 MoaE homodimer interface [polypeptide binding]; other site 1306414008369 MoaD interaction [polypeptide binding]; other site 1306414008370 active site residues [active] 1306414008371 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306414008372 S-adenosylmethionine binding site [chemical binding]; other site 1306414008373 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1306414008374 Cytochrome P450; Region: p450; cl12078 1306414008375 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 1306414008376 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1306414008377 DNA binding site [nucleotide binding] 1306414008378 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306414008379 PPE family; Region: PPE; pfam00823 1306414008380 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1306414008381 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1306414008382 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1306414008383 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1306414008384 dimer interface [polypeptide binding]; other site 1306414008385 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1306414008386 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1306414008387 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1306414008388 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1306414008389 Histidine kinase; Region: HisKA_3; pfam07730 1306414008390 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1306414008391 ATP binding site [chemical binding]; other site 1306414008392 Mg2+ binding site [ion binding]; other site 1306414008393 G-X-G motif; other site 1306414008394 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1306414008395 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1306414008396 active site 1306414008397 phosphorylation site [posttranslational modification] 1306414008398 intermolecular recognition site; other site 1306414008399 dimerization interface [polypeptide binding]; other site 1306414008400 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1306414008401 DNA binding residues [nucleotide binding] 1306414008402 dimerization interface [polypeptide binding]; other site 1306414008403 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1306414008404 Ligand Binding Site [chemical binding]; other site 1306414008405 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306414008406 PPE family; Region: PPE; pfam00823 1306414008407 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306414008408 PPE family; Region: PPE; pfam00823 1306414008409 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1306414008410 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1306414008411 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 1306414008412 active site 1306414008413 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 1306414008414 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1306414008415 FeS/SAM binding site; other site 1306414008416 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306414008417 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1306414008418 active site 1306414008419 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306414008420 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1306414008421 active site 1306414008422 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1306414008423 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 1306414008424 NAD(P) binding site [chemical binding]; other site 1306414008425 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1306414008426 active site 1306414008427 phosphorylation site [posttranslational modification] 1306414008428 intermolecular recognition site; other site 1306414008429 NADH dehydrogenase subunit A; Validated; Region: PRK07928 1306414008430 NADH dehydrogenase subunit B; Validated; Region: PRK06411 1306414008431 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 1306414008432 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1306414008433 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 1306414008434 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1306414008435 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1306414008436 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1306414008437 putative dimer interface [polypeptide binding]; other site 1306414008438 [2Fe-2S] cluster binding site [ion binding]; other site 1306414008439 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 1306414008440 SLBB domain; Region: SLBB; pfam10531 1306414008441 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 1306414008442 NADH dehydrogenase subunit G; Validated; Region: PRK07860 1306414008443 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1306414008444 catalytic loop [active] 1306414008445 iron binding site [ion binding]; other site 1306414008446 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1306414008447 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 1306414008448 [4Fe-4S] binding site [ion binding]; other site 1306414008449 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 1306414008450 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1306414008451 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1306414008452 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1306414008453 4Fe-4S binding domain; Region: Fer4; pfam00037 1306414008454 4Fe-4S binding domain; Region: Fer4; pfam00037 1306414008455 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1306414008456 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1306414008457 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1306414008458 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1306414008459 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1306414008460 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1306414008461 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1306414008462 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1306414008463 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1306414008464 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306414008465 PPE family; Region: PPE; pfam00823 1306414008466 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1306414008467 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306414008468 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1306414008469 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1306414008470 [2Fe-2S] cluster binding site [ion binding]; other site 1306414008471 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1306414008472 hydrophobic ligand binding site; other site 1306414008473 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1306414008474 Protein of unknown function DUF58; Region: DUF58; pfam01882 1306414008475 MoxR-like ATPases [General function prediction only]; Region: COG0714 1306414008476 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1306414008477 Walker A motif; other site 1306414008478 ATP binding site [chemical binding]; other site 1306414008479 Walker B motif; other site 1306414008480 arginine finger; other site 1306414008481 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1306414008482 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306414008483 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306414008484 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1306414008485 putative active site [active] 1306414008486 putative substrate binding site [chemical binding]; other site 1306414008487 ATP binding site [chemical binding]; other site 1306414008488 Phosphotransferase enzyme family; Region: APH; pfam01636 1306414008489 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1306414008490 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1306414008491 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1306414008492 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1306414008493 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1306414008494 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306414008495 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306414008496 short chain dehydrogenase; Validated; Region: PRK08264 1306414008497 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1306414008498 NAD(P) binding site [chemical binding]; other site 1306414008499 active site 1306414008500 amidase; Provisional; Region: PRK06170 1306414008501 Amidase; Region: Amidase; pfam01425 1306414008502 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1306414008503 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1306414008504 TAP-like protein; Region: Abhydrolase_4; pfam08386 1306414008505 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1306414008506 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 1306414008507 AAA domain; Region: AAA_14; pfam13173 1306414008508 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1306414008509 putative active site [active] 1306414008510 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1306414008511 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4683 1306414008512 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1306414008513 non-specific DNA binding site [nucleotide binding]; other site 1306414008514 salt bridge; other site 1306414008515 sequence-specific DNA binding site [nucleotide binding]; other site 1306414008516 RES domain; Region: RES; pfam08808 1306414008517 Winged helix-turn helix; Region: HTH_29; pfam13551 1306414008518 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1306414008519 Helix-turn-helix domain; Region: HTH_38; pfam13936 1306414008520 Integrase core domain; Region: rve; pfam00665 1306414008521 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1306414008522 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1306414008523 hypothetical protein; Validated; Region: PRK00068 1306414008524 Uncharacterized conserved protein [Function unknown]; Region: COG1615 1306414008525 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 1306414008526 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1306414008527 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1306414008528 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1306414008529 Uncharacterized conserved protein [Function unknown]; Region: COG5282 1306414008530 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 1306414008531 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 1306414008532 ABC1 family; Region: ABC1; pfam03109 1306414008533 Phosphotransferase enzyme family; Region: APH; pfam01636 1306414008534 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1306414008535 active site 1306414008536 ATP binding site [chemical binding]; other site 1306414008537 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1306414008538 Part of AAA domain; Region: AAA_19; pfam13245 1306414008539 Family description; Region: UvrD_C_2; pfam13538 1306414008540 HRDC domain; Region: HRDC; pfam00570 1306414008541 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1306414008542 catalytic residues [active] 1306414008543 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 1306414008544 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1306414008545 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1306414008546 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1306414008547 putative NADH binding site [chemical binding]; other site 1306414008548 putative active site [active] 1306414008549 nudix motif; other site 1306414008550 putative metal binding site [ion binding]; other site 1306414008551 Ion channel; Region: Ion_trans_2; pfam07885 1306414008552 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1306414008553 TrkA-N domain; Region: TrkA_N; pfam02254 1306414008554 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1306414008555 Part of AAA domain; Region: AAA_19; pfam13245 1306414008556 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 1306414008557 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1306414008558 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1306414008559 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 1306414008560 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1306414008561 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1306414008562 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1306414008563 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1306414008564 active site 1306414008565 DNA binding site [nucleotide binding] 1306414008566 TIGR02569 family protein; Region: TIGR02569_actnb 1306414008567 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 1306414008568 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1306414008569 ATP binding site [chemical binding]; other site 1306414008570 substrate interface [chemical binding]; other site 1306414008571 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1306414008572 active site residue [active] 1306414008573 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 1306414008574 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306414008575 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306414008576 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 1306414008577 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like; Region: MiaE_2; pfam13794 1306414008578 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1306414008579 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1306414008580 ATP binding site [chemical binding]; other site 1306414008581 Mg++ binding site [ion binding]; other site 1306414008582 motif III; other site 1306414008583 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1306414008584 nucleotide binding region [chemical binding]; other site 1306414008585 ATP-binding site [chemical binding]; other site 1306414008586 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1306414008587 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1306414008588 P-loop; other site 1306414008589 Magnesium ion binding site [ion binding]; other site 1306414008590 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1306414008591 Magnesium ion binding site [ion binding]; other site 1306414008592 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1306414008593 catalytic core [active] 1306414008594 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 1306414008595 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1306414008596 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1306414008597 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1306414008598 Transcription factor WhiB; Region: Whib; pfam02467 1306414008599 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 1306414008600 PAS domain S-box; Region: sensory_box; TIGR00229 1306414008601 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1306414008602 Histidine kinase; Region: HisKA_2; pfam07568 1306414008603 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1306414008604 ATP binding site [chemical binding]; other site 1306414008605 Mg2+ binding site [ion binding]; other site 1306414008606 G-X-G motif; other site 1306414008607 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1306414008608 carboxyltransferase (CT) interaction site; other site 1306414008609 biotinylation site [posttranslational modification]; other site 1306414008610 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 1306414008611 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 1306414008612 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1306414008613 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1306414008614 DNA binding residues [nucleotide binding] 1306414008615 short chain dehydrogenase; Provisional; Region: PRK08278 1306414008616 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 1306414008617 NAD(P) binding site [chemical binding]; other site 1306414008618 homodimer interface [polypeptide binding]; other site 1306414008619 active site 1306414008620 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1306414008621 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1306414008622 Coenzyme A binding pocket [chemical binding]; other site 1306414008623 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 1306414008624 Phosphotransferase enzyme family; Region: APH; pfam01636 1306414008625 putative active site [active] 1306414008626 putative substrate binding site [chemical binding]; other site 1306414008627 ATP binding site [chemical binding]; other site 1306414008628 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1306414008629 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1306414008630 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1306414008631 hinge; other site 1306414008632 active site 1306414008633 Predicted GTPases [General function prediction only]; Region: COG1162 1306414008634 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1306414008635 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1306414008636 GTP/Mg2+ binding site [chemical binding]; other site 1306414008637 G4 box; other site 1306414008638 G5 box; other site 1306414008639 G1 box; other site 1306414008640 Switch I region; other site 1306414008641 G2 box; other site 1306414008642 G3 box; other site 1306414008643 Switch II region; other site 1306414008644 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1306414008645 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1306414008646 putative di-iron ligands [ion binding]; other site 1306414008647 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 1306414008648 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1306414008649 FAD binding pocket [chemical binding]; other site 1306414008650 FAD binding motif [chemical binding]; other site 1306414008651 phosphate binding motif [ion binding]; other site 1306414008652 beta-alpha-beta structure motif; other site 1306414008653 NAD binding pocket [chemical binding]; other site 1306414008654 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1306414008655 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1306414008656 catalytic loop [active] 1306414008657 iron binding site [ion binding]; other site 1306414008658 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1306414008659 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1306414008660 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1306414008661 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1306414008662 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1306414008663 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1306414008664 TrkA-C domain; Region: TrkA_C; pfam02080 1306414008665 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1306414008666 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1306414008667 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1306414008668 putative substrate translocation pore; other site 1306414008669 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1306414008670 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1306414008671 ligand binding site [chemical binding]; other site 1306414008672 flexible hinge region; other site 1306414008673 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1306414008674 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1306414008675 nucleophile elbow; other site 1306414008676 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1306414008677 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1306414008678 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1306414008679 30S subunit binding site; other site 1306414008680 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1306414008681 active site 1306414008682 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 1306414008683 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1306414008684 lipoprotein LpqB; Provisional; Region: PRK13616 1306414008685 Sporulation and spore germination; Region: Germane; pfam10646 1306414008686 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1306414008687 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1306414008688 dimerization interface [polypeptide binding]; other site 1306414008689 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1306414008690 dimer interface [polypeptide binding]; other site 1306414008691 phosphorylation site [posttranslational modification] 1306414008692 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1306414008693 ATP binding site [chemical binding]; other site 1306414008694 Mg2+ binding site [ion binding]; other site 1306414008695 G-X-G motif; other site 1306414008696 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1306414008697 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1306414008698 active site 1306414008699 phosphorylation site [posttranslational modification] 1306414008700 intermolecular recognition site; other site 1306414008701 dimerization interface [polypeptide binding]; other site 1306414008702 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1306414008703 DNA binding site [nucleotide binding] 1306414008704 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 1306414008705 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1306414008706 TMP-binding site; other site 1306414008707 ATP-binding site [chemical binding]; other site 1306414008708 Adenosylhomocysteinase; Provisional; Region: PTZ00075 1306414008709 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1306414008710 homotetramer interface [polypeptide binding]; other site 1306414008711 ligand binding site [chemical binding]; other site 1306414008712 catalytic site [active] 1306414008713 NAD binding site [chemical binding]; other site 1306414008714 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306414008715 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1306414008716 Rubredoxin [Energy production and conversion]; Region: COG1773 1306414008717 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1306414008718 iron binding site [ion binding]; other site 1306414008719 Rubredoxin [Energy production and conversion]; Region: COG1773 1306414008720 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1306414008721 iron binding site [ion binding]; other site 1306414008722 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 1306414008723 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1306414008724 Di-iron ligands [ion binding]; other site 1306414008725 amino acid transporter; Region: 2A0306; TIGR00909 1306414008726 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1306414008727 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1306414008728 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1306414008729 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1306414008730 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1306414008731 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1306414008732 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 1306414008733 active site 1306414008734 substrate binding site [chemical binding]; other site 1306414008735 metal binding site [ion binding]; metal-binding site 1306414008736 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 1306414008737 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 1306414008738 Transcription factor WhiB; Region: Whib; pfam02467 1306414008739 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 1306414008740 LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186 1306414008741 phosphate binding site [ion binding]; other site 1306414008742 dimer interface [polypeptide binding]; other site 1306414008743 substrate binding site [chemical binding]; other site 1306414008744 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 1306414008745 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 1306414008746 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 1306414008747 putative FMN binding site [chemical binding]; other site 1306414008748 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1306414008749 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1306414008750 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1306414008751 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1306414008752 active site 1306414008753 Substrate binding site; other site 1306414008754 Mg++ binding site; other site 1306414008755 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1306414008756 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1306414008757 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1306414008758 Probable Catalytic site; other site 1306414008759 metal-binding site 1306414008760 dTDP-4-dehydrorhamnose reductase; Region: rmlD; TIGR01214 1306414008761 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1306414008762 NADP binding site [chemical binding]; other site 1306414008763 active site 1306414008764 putative substrate binding site [chemical binding]; other site 1306414008765 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1306414008766 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1306414008767 TIGR03089 family protein; Region: TIGR03089 1306414008768 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 1306414008769 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1306414008770 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1306414008771 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1306414008772 active site 1306414008773 motif I; other site 1306414008774 motif II; other site 1306414008775 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1306414008776 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1306414008777 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1306414008778 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1306414008779 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1306414008780 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: CynT; COG0288 1306414008781 active site clefts [active] 1306414008782 zinc binding site [ion binding]; other site 1306414008783 dimer interface [polypeptide binding]; other site 1306414008784 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306414008785 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1306414008786 FAD binding site [chemical binding]; other site 1306414008787 homotetramer interface [polypeptide binding]; other site 1306414008788 substrate binding pocket [chemical binding]; other site 1306414008789 catalytic base [active] 1306414008790 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1306414008791 Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) [Nucleotide transport and metabolism]; Region: PurK; COG0026 1306414008792 ATP-grasp domain; Region: ATP-grasp; pfam02222 1306414008793 Predicted membrane protein [Function unknown]; Region: COG2246 1306414008794 GtrA-like protein; Region: GtrA; pfam04138 1306414008795 Bacterial PH domain; Region: DUF304; pfam03703 1306414008796 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1306414008797 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1306414008798 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1306414008799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1306414008800 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1306414008801 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1306414008802 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 1306414008803 Maf-like protein; Region: Maf; pfam02545 1306414008804 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1306414008805 active site 1306414008806 dimer interface [polypeptide binding]; other site 1306414008807 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1306414008808 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1306414008809 active site residue [active] 1306414008810 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1306414008811 active site residue [active] 1306414008812 Fe-S metabolism associated domain; Region: SufE; pfam02657 1306414008813 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1306414008814 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1306414008815 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1306414008816 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1306414008817 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1306414008818 carboxyltransferase (CT) interaction site; other site 1306414008819 biotinylation site [posttranslational modification]; other site 1306414008820 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 1306414008821 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1306414008822 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1306414008823 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1306414008824 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1306414008825 L-lysine aminotransferase; Provisional; Region: PRK08297 1306414008826 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1306414008827 inhibitor-cofactor binding pocket; inhibition site 1306414008828 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1306414008829 catalytic residue [active] 1306414008830 putative DNA binding site [nucleotide binding]; other site 1306414008831 dimerization interface [polypeptide binding]; other site 1306414008832 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1306414008833 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1306414008834 putative Zn2+ binding site [ion binding]; other site 1306414008835 AsnC family; Region: AsnC_trans_reg; pfam01037 1306414008836 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 1306414008837 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 1306414008838 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1306414008839 tetrameric interface [polypeptide binding]; other site 1306414008840 NAD binding site [chemical binding]; other site 1306414008841 catalytic residues [active] 1306414008842 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 1306414008843 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306414008844 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306414008845 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1306414008846 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 1306414008847 ATP binding site [chemical binding]; other site 1306414008848 putative Mg++ binding site [ion binding]; other site 1306414008849 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1306414008850 nucleotide binding region [chemical binding]; other site 1306414008851 ATP-binding site [chemical binding]; other site 1306414008852 DEAD/H associated; Region: DEAD_assoc; pfam08494 1306414008853 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1306414008854 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 1306414008855 putative DNA binding site [nucleotide binding]; other site 1306414008856 catalytic residue [active] 1306414008857 putative H2TH interface [polypeptide binding]; other site 1306414008858 putative catalytic residues [active] 1306414008859 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1306414008860 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1306414008861 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1306414008862 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1306414008863 Sulfatase; Region: Sulfatase; pfam00884 1306414008864 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1306414008865 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1306414008866 active site 1306414008867 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1306414008868 PhoU domain; Region: PhoU; pfam01895 1306414008869 PhoU domain; Region: PhoU; pfam01895 1306414008870 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1306414008871 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1306414008872 putative active site pocket [active] 1306414008873 dimerization interface [polypeptide binding]; other site 1306414008874 putative catalytic residue [active] 1306414008875 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1306414008876 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 1306414008877 metal binding site [ion binding]; metal-binding site 1306414008878 putative dimer interface [polypeptide binding]; other site 1306414008879 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 1306414008880 amidohydrolase; Region: amidohydrolases; TIGR01891 1306414008881 metal binding site [ion binding]; metal-binding site 1306414008882 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1306414008883 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1306414008884 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1306414008885 active site 1306414008886 substrate binding site [chemical binding]; other site 1306414008887 metal binding site [ion binding]; metal-binding site 1306414008888 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1306414008889 active site 1306414008890 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1306414008891 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1306414008892 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1306414008893 adenosine deaminase; Provisional; Region: PRK09358 1306414008894 active site 1306414008895 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 1306414008896 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1306414008897 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1306414008898 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1306414008899 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1306414008900 active site 1306414008901 catalytic motif [active] 1306414008902 Zn binding site [ion binding]; other site 1306414008903 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 1306414008904 putative Iron-sulfur protein interface [polypeptide binding]; other site 1306414008905 putative proximal heme binding site [chemical binding]; other site 1306414008906 putative SdhD-like interface [polypeptide binding]; other site 1306414008907 putative distal heme binding site [chemical binding]; other site 1306414008908 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 1306414008909 putative Iron-sulfur protein interface [polypeptide binding]; other site 1306414008910 putative proximal heme binding site [chemical binding]; other site 1306414008911 putative SdhC-like subunit interface [polypeptide binding]; other site 1306414008912 putative distal heme binding site [chemical binding]; other site 1306414008913 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 1306414008914 L-aspartate oxidase; Provisional; Region: PRK06175 1306414008915 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1306414008916 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1306414008917 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1306414008918 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1306414008919 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1306414008920 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306414008921 S-adenosylmethionine binding site [chemical binding]; other site 1306414008922 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1306414008923 MoaE interaction surface [polypeptide binding]; other site 1306414008924 MoeB interaction surface [polypeptide binding]; other site 1306414008925 thiocarboxylated glycine; other site 1306414008926 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1306414008927 MoaE homodimer interface [polypeptide binding]; other site 1306414008928 MoaD interaction [polypeptide binding]; other site 1306414008929 active site residues [active] 1306414008930 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1306414008931 trimer interface [polypeptide binding]; other site 1306414008932 dimer interface [polypeptide binding]; other site 1306414008933 putative active site [active] 1306414008934 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1306414008935 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1306414008936 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1306414008937 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1306414008938 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 1306414008939 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1306414008940 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1306414008941 DNA binding residues [nucleotide binding] 1306414008942 SnoaL-like domain; Region: SnoaL_2; pfam12680 1306414008943 hypothetical protein; Provisional; Region: PRK06541 1306414008944 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1306414008945 inhibitor-cofactor binding pocket; inhibition site 1306414008946 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1306414008947 catalytic residue [active] 1306414008948 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1306414008949 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1306414008950 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1306414008951 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1306414008952 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1306414008953 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1306414008954 active site 1306414008955 dimer interface [polypeptide binding]; other site 1306414008956 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1306414008957 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 1306414008958 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1306414008959 DNA binding residues [nucleotide binding] 1306414008960 dimer interface [polypeptide binding]; other site 1306414008961 metal binding site [ion binding]; metal-binding site 1306414008962 inner membrane protein YhjD; Region: TIGR00766 1306414008963 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1306414008964 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1306414008965 active site 1306414008966 HIGH motif; other site 1306414008967 dimer interface [polypeptide binding]; other site 1306414008968 KMSKS motif; other site 1306414008969 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1306414008970 isocitrate dehydrogenase; Validated; Region: PRK08299 1306414008971 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 1306414008972 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1306414008973 homodimer interface [polypeptide binding]; other site 1306414008974 substrate-cofactor binding pocket; other site 1306414008975 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1306414008976 catalytic residue [active] 1306414008977 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 1306414008978 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 1306414008979 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1306414008980 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306414008981 S-adenosylmethionine binding site [chemical binding]; other site 1306414008982 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306414008983 PPE family; Region: PPE; pfam00823 1306414008984 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306414008985 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306414008986 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306414008987 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306414008988 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306414008989 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306414008990 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306414008991 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306414008992 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306414008993 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306414008994 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306414008995 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306414008996 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306414008997 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306414008998 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306414008999 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 1306414009000 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1306414009001 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1306414009002 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306414009003 PPE family; Region: PPE; pfam00823 1306414009004 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306414009005 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306414009006 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306414009007 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306414009008 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306414009009 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306414009010 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306414009011 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306414009012 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306414009013 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306414009014 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306414009015 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306414009016 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306414009017 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306414009018 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306414009019 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306414009020 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1306414009021 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 1306414009022 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 1306414009023 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1306414009024 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1306414009025 homodimer interface [polypeptide binding]; other site 1306414009026 NADP binding site [chemical binding]; other site 1306414009027 substrate binding site [chemical binding]; other site 1306414009028 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 1306414009029 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 1306414009030 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1306414009031 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1306414009032 phosphopeptide binding site; other site 1306414009033 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1306414009034 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1306414009035 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1306414009036 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1306414009037 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1306414009038 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 1306414009039 G1 box; other site 1306414009040 GTP/Mg2+ binding site [chemical binding]; other site 1306414009041 G2 box; other site 1306414009042 Switch I region; other site 1306414009043 G3 box; other site 1306414009044 Switch II region; other site 1306414009045 G4 box; other site 1306414009046 G5 box; other site 1306414009047 Protein of unknown function (DUF742); Region: DUF742; pfam05331 1306414009048 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 1306414009049 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1306414009050 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1306414009051 ATP binding site [chemical binding]; other site 1306414009052 Mg2+ binding site [ion binding]; other site 1306414009053 G-X-G motif; other site 1306414009054 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1306414009055 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 1306414009056 FMN binding site [chemical binding]; other site 1306414009057 dimer interface [polypeptide binding]; other site 1306414009058 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1306414009059 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 1306414009060 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1306414009061 active site 1306414009062 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1306414009063 generic binding surface II; other site 1306414009064 generic binding surface I; other site 1306414009065 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1306414009066 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1306414009067 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1306414009068 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 1306414009069 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1306414009070 active site 1306414009071 motif I; other site 1306414009072 motif II; other site 1306414009073 PE family; Region: PE; pfam00934 1306414009074 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1306414009075 substrate binding site [chemical binding]; other site 1306414009076 oxyanion hole (OAH) forming residues; other site 1306414009077 trimer interface [polypeptide binding]; other site 1306414009078 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 1306414009079 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1306414009080 Amidase; Region: Amidase; pfam01425 1306414009081 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1306414009082 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1306414009083 motif II; other site 1306414009084 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 1306414009085 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 1306414009086 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12571 1306414009087 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1306414009088 TPP-binding site; other site 1306414009089 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1306414009090 PYR/PP interface [polypeptide binding]; other site 1306414009091 dimer interface [polypeptide binding]; other site 1306414009092 TPP binding site [chemical binding]; other site 1306414009093 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1306414009094 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1306414009095 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1306414009096 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1306414009097 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1306414009098 substrate binding pocket [chemical binding]; other site 1306414009099 chain length determination region; other site 1306414009100 substrate-Mg2+ binding site; other site 1306414009101 catalytic residues [active] 1306414009102 aspartate-rich region 1; other site 1306414009103 active site lid residues [active] 1306414009104 aspartate-rich region 2; other site 1306414009105 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 1306414009106 putative active site [active] 1306414009107 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1306414009108 PE family; Region: PE; pfam00934 1306414009109 enoyl-CoA hydratase; Region: PLN02864 1306414009110 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1306414009111 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 1306414009112 dimer interaction site [polypeptide binding]; other site 1306414009113 substrate-binding tunnel; other site 1306414009114 active site 1306414009115 catalytic site [active] 1306414009116 substrate binding site [chemical binding]; other site 1306414009117 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1306414009118 short chain dehydrogenase; Provisional; Region: PRK07201 1306414009119 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 1306414009120 putative NAD(P) binding site [chemical binding]; other site 1306414009121 active site 1306414009122 putative substrate binding site [chemical binding]; other site 1306414009123 classical (c) SDRs; Region: SDR_c; cd05233 1306414009124 NAD(P) binding site [chemical binding]; other site 1306414009125 active site 1306414009126 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1306414009127 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306414009128 S-adenosylmethionine binding site [chemical binding]; other site 1306414009129 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 1306414009130 active site 1306414009131 DNA Polymerase Y-family; Region: PolY_like; cd03468 1306414009132 DNA binding site [nucleotide binding] 1306414009133 GMP synthase; Reviewed; Region: guaA; PRK00074 1306414009134 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1306414009135 AMP/PPi binding site [chemical binding]; other site 1306414009136 candidate oxyanion hole; other site 1306414009137 catalytic triad [active] 1306414009138 potential glutamine specificity residues [chemical binding]; other site 1306414009139 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1306414009140 ATP Binding subdomain [chemical binding]; other site 1306414009141 Ligand Binding sites [chemical binding]; other site 1306414009142 Dimerization subdomain; other site 1306414009143 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1306414009144 active site lid residues [active] 1306414009145 substrate binding pocket [chemical binding]; other site 1306414009146 catalytic residues [active] 1306414009147 substrate-Mg2+ binding site; other site 1306414009148 aspartate-rich region 1; other site 1306414009149 aspartate-rich region 2; other site 1306414009150 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1306414009151 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1306414009152 substrate binding pocket [chemical binding]; other site 1306414009153 chain length determination region; other site 1306414009154 substrate-Mg2+ binding site; other site 1306414009155 catalytic residues [active] 1306414009156 aspartate-rich region 1; other site 1306414009157 active site lid residues [active] 1306414009158 aspartate-rich region 2; other site 1306414009159 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1306414009160 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1306414009161 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1306414009162 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1306414009163 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1306414009164 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1306414009165 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1306414009166 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1306414009167 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1306414009168 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1306414009169 inhibitor-cofactor binding pocket; inhibition site 1306414009170 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1306414009171 catalytic residue [active] 1306414009172 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 1306414009173 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1306414009174 hypothetical protein; Provisional; Region: PRK07579 1306414009175 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 1306414009176 active site 1306414009177 cosubstrate binding site; other site 1306414009178 substrate binding site [chemical binding]; other site 1306414009179 catalytic site [active] 1306414009180 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306414009181 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306414009182 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1306414009183 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1306414009184 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1306414009185 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 1306414009186 putative active site [active] 1306414009187 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1306414009188 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1306414009189 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1306414009190 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 1306414009191 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1306414009192 phosphate binding site [ion binding]; other site 1306414009193 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1306414009194 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1306414009195 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1306414009196 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1306414009197 active site 1306414009198 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 1306414009199 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1306414009200 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1306414009201 DNA binding residues [nucleotide binding] 1306414009202 Transcription factor WhiB; Region: Whib; pfam02467 1306414009203 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1306414009204 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1306414009205 ring oligomerisation interface [polypeptide binding]; other site 1306414009206 ATP/Mg binding site [chemical binding]; other site 1306414009207 stacking interactions; other site 1306414009208 hinge regions; other site 1306414009209 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1306414009210 oligomerisation interface [polypeptide binding]; other site 1306414009211 mobile loop; other site 1306414009212 roof hairpin; other site 1306414009213 UGMP family protein; Validated; Region: PRK09604 1306414009214 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1306414009215 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1306414009216 Coenzyme A binding pocket [chemical binding]; other site 1306414009217 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 1306414009218 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 1306414009219 alanine racemase; Reviewed; Region: alr; PRK00053 1306414009220 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1306414009221 active site 1306414009222 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1306414009223 dimer interface [polypeptide binding]; other site 1306414009224 substrate binding site [chemical binding]; other site 1306414009225 catalytic residues [active] 1306414009226 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306414009227 PPE family; Region: PPE; pfam00823 1306414009228 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306414009229 PPE family; Region: PPE; pfam00823 1306414009230 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306414009231 PPE family; Region: PPE; pfam00823 1306414009232 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1306414009233 MULE transposase domain; Region: MULE; pfam10551 1306414009234 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 1306414009235 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1306414009236 catalytic residue [active] 1306414009237 Uncharacterized conserved protein [Function unknown]; Region: COG0062 1306414009238 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1306414009239 putative substrate binding site [chemical binding]; other site 1306414009240 putative ATP binding site [chemical binding]; other site 1306414009241 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1306414009242 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1306414009243 glutaminase active site [active] 1306414009244 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1306414009245 dimer interface [polypeptide binding]; other site 1306414009246 active site 1306414009247 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1306414009248 dimer interface [polypeptide binding]; other site 1306414009249 active site 1306414009250 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 1306414009251 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 1306414009252 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1306414009253 active site 1306414009254 substrate binding site [chemical binding]; other site 1306414009255 metal binding site [ion binding]; metal-binding site 1306414009256 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1306414009257 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1306414009258 23S rRNA interface [nucleotide binding]; other site 1306414009259 L3 interface [polypeptide binding]; other site 1306414009260 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1306414009261 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1306414009262 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 1306414009263 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1306414009264 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1306414009265 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1306414009266 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1306414009267 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1306414009268 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1306414009269 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1306414009270 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1306414009271 active site 1306414009272 catalytic residues [active] 1306414009273 Protein of unknown function (DUF690); Region: DUF690; pfam05108 1306414009274 Cutinase; Region: Cutinase; pfam01083 1306414009275 Cutinase; Region: Cutinase; pfam01083 1306414009276 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1306414009277 Pseudouridylate synthase [Translation, ribosomal structure and biogenesis]; Region: TruA; COG0101 1306414009278 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1306414009279 dimerization interface 3.5A [polypeptide binding]; other site 1306414009280 active site 1306414009281 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1306414009282 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1306414009283 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1306414009284 alphaNTD - beta interaction site [polypeptide binding]; other site 1306414009285 alphaNTD homodimer interface [polypeptide binding]; other site 1306414009286 alphaNTD - beta' interaction site [polypeptide binding]; other site 1306414009287 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1306414009288 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1306414009289 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1306414009290 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1306414009291 RNA binding surface [nucleotide binding]; other site 1306414009292 30S ribosomal protein S11; Validated; Region: PRK05309 1306414009293 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1306414009294 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1306414009295 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1306414009296 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1306414009297 rRNA binding site [nucleotide binding]; other site 1306414009298 predicted 30S ribosome binding site; other site 1306414009299 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1306414009300 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 1306414009301 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1306414009302 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1306414009303 NAD binding site [chemical binding]; other site 1306414009304 substrate binding site [chemical binding]; other site 1306414009305 homodimer interface [polypeptide binding]; other site 1306414009306 active site 1306414009307 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 1306414009308 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1306414009309 extended (e) SDRs; Region: SDR_e; cd08946 1306414009310 NAD(P) binding site [chemical binding]; other site 1306414009311 active site 1306414009312 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 1306414009313 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 1306414009314 active site 1306414009315 catalytic residues [active] 1306414009316 metal binding site [ion binding]; metal-binding site 1306414009317 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1306414009318 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1306414009319 PYR/PP interface [polypeptide binding]; other site 1306414009320 dimer interface [polypeptide binding]; other site 1306414009321 TPP binding site [chemical binding]; other site 1306414009322 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1306414009323 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1306414009324 TPP-binding site [chemical binding]; other site 1306414009325 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1306414009326 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1306414009327 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1306414009328 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1306414009329 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1306414009330 metabolite-proton symporter; Region: 2A0106; TIGR00883 1306414009331 putative substrate translocation pore; other site 1306414009332 PE family; Region: PE; pfam00934 1306414009333 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306414009334 PPE family; Region: PPE; pfam00823 1306414009335 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1306414009336 patatin-related protein; Region: TIGR03607 1306414009337 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1306414009338 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1306414009339 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 1306414009340 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1306414009341 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 1306414009342 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 1306414009343 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1306414009344 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1306414009345 short chain dehydrogenase; Provisional; Region: PRK05875 1306414009346 classical (c) SDRs; Region: SDR_c; cd05233 1306414009347 NAD(P) binding site [chemical binding]; other site 1306414009348 active site 1306414009349 Predicted membrane protein [Function unknown]; Region: COG2259 1306414009350 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1306414009351 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1306414009352 Predicted transcriptional regulators [Transcription]; Region: COG1695 1306414009353 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1306414009354 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 1306414009355 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1306414009356 active site 1306414009357 homotetramer interface [polypeptide binding]; other site 1306414009358 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1306414009359 mce related protein; Region: MCE; pfam02470 1306414009360 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1306414009361 mce related protein; Region: MCE; pfam02470 1306414009362 mce related protein; Region: MCE; pfam02470 1306414009363 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1306414009364 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1306414009365 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1306414009366 mce related protein; Region: MCE; pfam02470 1306414009367 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1306414009368 mce related protein; Region: MCE; pfam02470 1306414009369 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1306414009370 mce related protein; Region: MCE; pfam02470 1306414009371 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1306414009372 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1306414009373 Permease; Region: Permease; pfam02405 1306414009374 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1306414009375 Permease; Region: Permease; pfam02405 1306414009376 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 1306414009377 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1306414009378 NAD(P) binding site [chemical binding]; other site 1306414009379 active site 1306414009380 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1306414009381 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1306414009382 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306414009383 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 1306414009384 FAD binding site [chemical binding]; other site 1306414009385 substrate binding site [chemical binding]; other site 1306414009386 catalytic base [active] 1306414009387 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306414009388 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1306414009389 active site 1306414009390 acyl-CoA synthetase; Validated; Region: PRK07867 1306414009391 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 1306414009392 acyl-activating enzyme (AAE) consensus motif; other site 1306414009393 putative AMP binding site [chemical binding]; other site 1306414009394 putative active site [active] 1306414009395 putative CoA binding site [chemical binding]; other site 1306414009396 PE family; Region: PE; pfam00934 1306414009397 PE family; Region: PE; pfam00934 1306414009398 hypothetical protein; Validated; Region: PRK07586 1306414009399 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1306414009400 PYR/PP interface [polypeptide binding]; other site 1306414009401 dimer interface [polypeptide binding]; other site 1306414009402 TPP binding site [chemical binding]; other site 1306414009403 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 1306414009404 TPP-binding site [chemical binding]; other site 1306414009405 dimer interface [polypeptide binding]; other site 1306414009406 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1306414009407 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1306414009408 CoA binding site [chemical binding]; other site 1306414009409 PE family; Region: PE; pfam00934 1306414009410 acyl-CoA synthetase; Validated; Region: PRK07798 1306414009411 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1306414009412 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 1306414009413 acyl-activating enzyme (AAE) consensus motif; other site 1306414009414 acyl-activating enzyme (AAE) consensus motif; other site 1306414009415 putative AMP binding site [chemical binding]; other site 1306414009416 putative active site [active] 1306414009417 putative CoA binding site [chemical binding]; other site 1306414009418 enoyl-CoA hydratase; Provisional; Region: PRK07799 1306414009419 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1306414009420 substrate binding site [chemical binding]; other site 1306414009421 oxyanion hole (OAH) forming residues; other site 1306414009422 trimer interface [polypeptide binding]; other site 1306414009423 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1306414009424 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1306414009425 Cytochrome P450; Region: p450; cl12078 1306414009426 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 1306414009427 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1306414009428 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 1306414009429 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1306414009430 DUF35 OB-fold domain; Region: DUF35; pfam01796 1306414009431 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1306414009432 DUF35 OB-fold domain; Region: DUF35; pfam01796 1306414009433 lipid-transfer protein; Provisional; Region: PRK07937 1306414009434 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1306414009435 active site 1306414009436 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 1306414009437 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1306414009438 active site 1306414009439 NHL repeat; Region: NHL; pfam01436 1306414009440 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1306414009441 NHL repeat; Region: NHL; pfam01436 1306414009442 NHL repeat; Region: NHL; pfam01436 1306414009443 NHL repeat; Region: NHL; pfam01436 1306414009444 NHL repeat; Region: NHL; pfam01436 1306414009445 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1306414009446 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1306414009447 trimer interface [polypeptide binding]; other site 1306414009448 putative metal binding site [ion binding]; other site 1306414009449 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1306414009450 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 1306414009451 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 1306414009452 short chain dehydrogenase; Provisional; Region: PRK07890 1306414009453 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1306414009454 NAD(P) binding site [chemical binding]; other site 1306414009455 active site 1306414009456 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306414009457 PPE family; Region: PPE; pfam00823 1306414009458 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1306414009459 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306414009460 PPE family; Region: PPE; pfam00823 1306414009461 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306414009462 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306414009463 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 1306414009464 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 1306414009465 active site 1306414009466 catalytic residues [active] 1306414009467 metal binding site [ion binding]; metal-binding site 1306414009468 DmpG-like communication domain; Region: DmpG_comm; pfam07836 1306414009469 acetaldehyde dehydrogenase; Validated; Region: PRK08300 1306414009470 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1306414009471 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 1306414009472 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971 1306414009473 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 1306414009474 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1306414009475 enoyl-CoA hydratase; Region: PLN02864 1306414009476 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1306414009477 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 1306414009478 dimer interaction site [polypeptide binding]; other site 1306414009479 substrate-binding tunnel; other site 1306414009480 active site 1306414009481 catalytic site [active] 1306414009482 substrate binding site [chemical binding]; other site 1306414009483 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306414009484 PPE family; Region: PPE; pfam00823 1306414009485 PE-PPE domain; Region: PE-PPE; pfam08237 1306414009486 lipid-transfer protein; Provisional; Region: PRK07855 1306414009487 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1306414009488 active site 1306414009489 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 1306414009490 putative active site [active] 1306414009491 putative catalytic site [active] 1306414009492 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1306414009493 active site 1306414009494 catalytic site [active] 1306414009495 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1306414009496 DUF35 OB-fold domain; Region: DUF35; pfam01796 1306414009497 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306414009498 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1306414009499 active site 1306414009500 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306414009501 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1306414009502 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1306414009503 active site 1306414009504 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1306414009505 Cytochrome P450; Region: p450; cl12078 1306414009506 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 1306414009507 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1306414009508 dimer interface [polypeptide binding]; other site 1306414009509 active site 1306414009510 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1306414009511 short chain dehydrogenase; Provisional; Region: PRK07791 1306414009512 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 1306414009513 homodimer interface [polypeptide binding]; other site 1306414009514 NAD binding site [chemical binding]; other site 1306414009515 active site 1306414009516 short chain dehydrogenase; Provisional; Region: PRK07856 1306414009517 classical (c) SDRs; Region: SDR_c; cd05233 1306414009518 NAD(P) binding site [chemical binding]; other site 1306414009519 active site 1306414009520 enoyl-CoA hydratase; Provisional; Region: PRK06495 1306414009521 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1306414009522 substrate binding site [chemical binding]; other site 1306414009523 oxyanion hole (OAH) forming residues; other site 1306414009524 trimer interface [polypeptide binding]; other site 1306414009525 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1306414009526 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057 1306414009527 Nitronate monooxygenase; Region: NMO; pfam03060 1306414009528 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1306414009529 FMN binding site [chemical binding]; other site 1306414009530 substrate binding site [chemical binding]; other site 1306414009531 putative catalytic residue [active] 1306414009532 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1306414009533 Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514 1306414009534 putative di-iron ligands [ion binding]; other site 1306414009535 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1306414009536 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1306414009537 FAD binding pocket [chemical binding]; other site 1306414009538 FAD binding motif [chemical binding]; other site 1306414009539 phosphate binding motif [ion binding]; other site 1306414009540 beta-alpha-beta structure motif; other site 1306414009541 NAD(p) ribose binding residues [chemical binding]; other site 1306414009542 NAD binding pocket [chemical binding]; other site 1306414009543 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1306414009544 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1306414009545 catalytic loop [active] 1306414009546 iron binding site [ion binding]; other site 1306414009547 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1306414009548 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1306414009549 putative active site [active] 1306414009550 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 1306414009551 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1306414009552 dimer interface [polypeptide binding]; other site 1306414009553 active site 1306414009554 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306414009555 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306414009556 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306414009557 PPE family; Region: PPE; pfam00823 1306414009558 short chain dehydrogenase; Provisional; Region: PRK07831 1306414009559 classical (c) SDRs; Region: SDR_c; cd05233 1306414009560 NAD(P) binding site [chemical binding]; other site 1306414009561 active site 1306414009562 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306414009563 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1306414009564 active site 1306414009565 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1306414009566 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1306414009567 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1306414009568 acyl-activating enzyme (AAE) consensus motif; other site 1306414009569 putative AMP binding site [chemical binding]; other site 1306414009570 putative active site [active] 1306414009571 putative CoA binding site [chemical binding]; other site 1306414009572 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306414009573 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1306414009574 active site 1306414009575 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306414009576 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1306414009577 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1306414009578 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306414009579 active site 1306414009580 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306414009581 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1306414009582 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1306414009583 active site 1306414009584 aspartate aminotransferase; Provisional; Region: PRK05764 1306414009585 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1306414009586 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1306414009587 homodimer interface [polypeptide binding]; other site 1306414009588 catalytic residue [active] 1306414009589 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 1306414009590 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1306414009591 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 1306414009592 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 1306414009593 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 1306414009594 active site 1306414009595 Fe binding site [ion binding]; other site 1306414009596 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 1306414009597 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306414009598 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 1306414009599 Flavin binding site [chemical binding]; other site 1306414009600 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1306414009601 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1306414009602 FAD binding pocket [chemical binding]; other site 1306414009603 FAD binding motif [chemical binding]; other site 1306414009604 phosphate binding motif [ion binding]; other site 1306414009605 beta-alpha-beta structure motif; other site 1306414009606 NAD(p) ribose binding residues [chemical binding]; other site 1306414009607 NAD binding pocket [chemical binding]; other site 1306414009608 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1306414009609 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1306414009610 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1306414009611 catalytic loop [active] 1306414009612 iron binding site [ion binding]; other site 1306414009613 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306414009614 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1306414009615 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1306414009616 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306414009617 active site 1306414009618 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306414009619 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306414009620 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1306414009621 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1306414009622 DNA binding site [nucleotide binding] 1306414009623 domain linker motif; other site 1306414009624 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 1306414009625 putative dimerization interface [polypeptide binding]; other site 1306414009626 putative ligand binding site [chemical binding]; other site 1306414009627 PknH-like extracellular domain; Region: PknH_C; pfam14032 1306414009628 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1306414009629 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1306414009630 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1306414009631 transmembrane helices; other site 1306414009632 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1306414009633 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1306414009634 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1306414009635 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1306414009636 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1306414009637 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1306414009638 active site 1306414009639 HIGH motif; other site 1306414009640 nucleotide binding site [chemical binding]; other site 1306414009641 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1306414009642 KMSKS motif; other site 1306414009643 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1306414009644 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1306414009645 homotrimer interaction site [polypeptide binding]; other site 1306414009646 zinc binding site [ion binding]; other site 1306414009647 CDP-binding sites; other site 1306414009648 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1306414009649 substrate binding site; other site 1306414009650 dimer interface; other site 1306414009651 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 1306414009652 DNA repair protein RadA; Provisional; Region: PRK11823 1306414009653 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1306414009654 Walker A motif/ATP binding site; other site 1306414009655 ATP binding site [chemical binding]; other site 1306414009656 Walker B motif; other site 1306414009657 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1306414009658 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 1306414009659 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1306414009660 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 1306414009661 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 1306414009662 active site clefts [active] 1306414009663 zinc binding site [ion binding]; other site 1306414009664 dimer interface [polypeptide binding]; other site 1306414009665 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1306414009666 endonuclease III; Region: ENDO3c; smart00478 1306414009667 minor groove reading motif; other site 1306414009668 helix-hairpin-helix signature motif; other site 1306414009669 substrate binding pocket [chemical binding]; other site 1306414009670 active site 1306414009671 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1306414009672 PE family; Region: PE; pfam00934 1306414009673 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1306414009674 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1306414009675 catalytic site [active] 1306414009676 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1306414009677 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 1306414009678 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1306414009679 Ami_2 domain; Region: Ami_2; smart00644 1306414009680 amidase catalytic site [active] 1306414009681 Zn binding residues [ion binding]; other site 1306414009682 substrate binding site [chemical binding]; other site 1306414009683 PE family; Region: PE; pfam00934 1306414009684 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1306414009685 Clp amino terminal domain; Region: Clp_N; pfam02861 1306414009686 Clp amino terminal domain; Region: Clp_N; pfam02861 1306414009687 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1306414009688 Walker A motif; other site 1306414009689 ATP binding site [chemical binding]; other site 1306414009690 Walker B motif; other site 1306414009691 arginine finger; other site 1306414009692 UvrB/uvrC motif; Region: UVR; pfam02151 1306414009693 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1306414009694 Walker A motif; other site 1306414009695 ATP binding site [chemical binding]; other site 1306414009696 Walker B motif; other site 1306414009697 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1306414009698 Lsr2; Region: Lsr2; pfam11774 1306414009699 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1306414009700 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1306414009701 dimer interface [polypeptide binding]; other site 1306414009702 putative anticodon binding site; other site 1306414009703 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1306414009704 motif 1; other site 1306414009705 dimer interface [polypeptide binding]; other site 1306414009706 active site 1306414009707 motif 2; other site 1306414009708 motif 3; other site 1306414009709 pantothenate kinase; Reviewed; Region: PRK13318 1306414009710 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1306414009711 tetramerization interface [polypeptide binding]; other site 1306414009712 active site 1306414009713 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1306414009714 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1306414009715 active site 1306414009716 ATP-binding site [chemical binding]; other site 1306414009717 pantoate-binding site; other site 1306414009718 HXXH motif; other site 1306414009719 Rossmann-like domain; Region: Rossmann-like; pfam10727 1306414009720 Uncharacterized conserved protein [Function unknown]; Region: COG5495 1306414009721 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 1306414009722 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 1306414009723 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1306414009724 catalytic center binding site [active] 1306414009725 ATP binding site [chemical binding]; other site 1306414009726 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1306414009727 homooctamer interface [polypeptide binding]; other site 1306414009728 active site 1306414009729 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1306414009730 dihydropteroate synthase; Region: DHPS; TIGR01496 1306414009731 substrate binding pocket [chemical binding]; other site 1306414009732 dimer interface [polypeptide binding]; other site 1306414009733 inhibitor binding site; inhibition site 1306414009734 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1306414009735 homodecamer interface [polypeptide binding]; other site 1306414009736 GTP cyclohydrolase I; Provisional; Region: PLN03044 1306414009737 active site 1306414009738 putative catalytic site residues [active] 1306414009739 zinc binding site [ion binding]; other site 1306414009740 GTP-CH-I/GFRP interaction surface; other site 1306414009741 FtsH Extracellular; Region: FtsH_ext; pfam06480 1306414009742 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1306414009743 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1306414009744 Walker A motif; other site 1306414009745 ATP binding site [chemical binding]; other site 1306414009746 Walker B motif; other site 1306414009747 arginine finger; other site 1306414009748 Peptidase family M41; Region: Peptidase_M41; pfam01434 1306414009749 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 1306414009750 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1306414009751 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1306414009752 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1306414009753 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1306414009754 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1306414009755 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1306414009756 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306414009757 PPE family; Region: PPE; pfam00823 1306414009758 PE family; Region: PE; pfam00934 1306414009759 Uncharacterized conserved protein [Function unknown]; Region: COG2968 1306414009760 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 1306414009761 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1306414009762 active site 1306414009763 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1306414009764 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1306414009765 Ligand Binding Site [chemical binding]; other site 1306414009766 Uncharacterized conserved protein [Function unknown]; Region: COG5282 1306414009767 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 1306414009768 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113 1306414009769 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1306414009770 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1306414009771 dimer interface [polypeptide binding]; other site 1306414009772 substrate binding site [chemical binding]; other site 1306414009773 metal binding sites [ion binding]; metal-binding site 1306414009774 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2899 1306414009775 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1306414009776 Ligand binding site; other site 1306414009777 Putative Catalytic site; other site 1306414009778 DXD motif; other site 1306414009779 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 1306414009780 Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5285 1306414009781 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1306414009782 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1306414009783 NAD(P) binding site [chemical binding]; other site 1306414009784 active site 1306414009785 transposase; Provisional; Region: PRK06526 1306414009786 IstB-like ATP binding protein; Region: IstB_IS21; pfam01695 1306414009787 Walker B motif; other site 1306414009788 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1306414009789 MULE transposase domain; Region: MULE; pfam10551 1306414009790 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 1306414009791 Fic/DOC family; Region: Fic; cl00960 1306414009792 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 1306414009793 DNA polymerase III subunit delta'; Validated; Region: PRK07940 1306414009794 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1306414009795 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1306414009796 dimerization interface [polypeptide binding]; other site 1306414009797 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1306414009798 cyclase homology domain; Region: CHD; cd07302 1306414009799 nucleotidyl binding site; other site 1306414009800 metal binding site [ion binding]; metal-binding site 1306414009801 dimer interface [polypeptide binding]; other site 1306414009802 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1306414009803 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1306414009804 active site 1306414009805 interdomain interaction site; other site 1306414009806 putative metal-binding site [ion binding]; other site 1306414009807 nucleotide binding site [chemical binding]; other site 1306414009808 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 1306414009809 domain I; other site 1306414009810 phosphate binding site [ion binding]; other site 1306414009811 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1306414009812 domain II; other site 1306414009813 domain III; other site 1306414009814 nucleotide binding site [chemical binding]; other site 1306414009815 DNA binding groove [nucleotide binding] 1306414009816 catalytic site [active] 1306414009817 domain IV; other site 1306414009818 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1306414009819 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1306414009820 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1306414009821 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1306414009822 DNA-binding site [nucleotide binding]; DNA binding site 1306414009823 RNA-binding motif; other site 1306414009824 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 1306414009825 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1306414009826 ATP binding site [chemical binding]; other site 1306414009827 putative Mg++ binding site [ion binding]; other site 1306414009828 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1306414009829 nucleotide binding region [chemical binding]; other site 1306414009830 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1306414009831 PE family; Region: PE; pfam00934 1306414009832 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 1306414009833 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1306414009834 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1306414009835 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1306414009836 Walker A motif; other site 1306414009837 ATP binding site [chemical binding]; other site 1306414009838 Walker B motif; other site 1306414009839 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 1306414009840 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1306414009841 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1306414009842 motif II; other site 1306414009843 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1306414009844 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1306414009845 Walker A/P-loop; other site 1306414009846 ATP binding site [chemical binding]; other site 1306414009847 Q-loop/lid; other site 1306414009848 ABC transporter signature motif; other site 1306414009849 Walker B; other site 1306414009850 D-loop; other site 1306414009851 H-loop/switch region; other site 1306414009852 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1306414009853 Walker A/P-loop; other site 1306414009854 ATP binding site [chemical binding]; other site 1306414009855 Q-loop/lid; other site 1306414009856 ABC transporter signature motif; other site 1306414009857 Walker B; other site 1306414009858 D-loop; other site 1306414009859 H-loop/switch region; other site 1306414009860 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1306414009861 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1306414009862 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1306414009863 putative PBP binding loops; other site 1306414009864 dimer interface [polypeptide binding]; other site 1306414009865 ABC-ATPase subunit interface; other site 1306414009866 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1306414009867 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1306414009868 dimer interface [polypeptide binding]; other site 1306414009869 conserved gate region; other site 1306414009870 ABC-ATPase subunit interface; other site 1306414009871 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1306414009872 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1306414009873 acetyl-CoA synthetase; Provisional; Region: PRK00174 1306414009874 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1306414009875 active site 1306414009876 CoA binding site [chemical binding]; other site 1306414009877 acyl-activating enzyme (AAE) consensus motif; other site 1306414009878 AMP binding site [chemical binding]; other site 1306414009879 acetate binding site [chemical binding]; other site 1306414009880 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 1306414009881 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1306414009882 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1306414009883 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1306414009884 putative active site [active] 1306414009885 putative CoA binding site [chemical binding]; other site 1306414009886 nudix motif; other site 1306414009887 metal binding site [ion binding]; metal-binding site 1306414009888 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1306414009889 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1306414009890 catalytic residues [active] 1306414009891 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1306414009892 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1306414009893 minor groove reading motif; other site 1306414009894 helix-hairpin-helix signature motif; other site 1306414009895 substrate binding pocket [chemical binding]; other site 1306414009896 active site 1306414009897 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1306414009898 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1306414009899 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1306414009900 ligand binding site [chemical binding]; other site 1306414009901 flexible hinge region; other site 1306414009902 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1306414009903 putative switch regulator; other site 1306414009904 non-specific DNA interactions [nucleotide binding]; other site 1306414009905 DNA binding site [nucleotide binding] 1306414009906 sequence specific DNA binding site [nucleotide binding]; other site 1306414009907 putative cAMP binding site [chemical binding]; other site 1306414009908 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1306414009909 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1306414009910 homotrimer interaction site [polypeptide binding]; other site 1306414009911 putative active site [active] 1306414009912 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1306414009913 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1306414009914 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1306414009915 P loop; other site 1306414009916 Nucleotide binding site [chemical binding]; other site 1306414009917 DTAP/Switch II; other site 1306414009918 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1306414009919 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1306414009920 DTAP/Switch II; other site 1306414009921 Switch I; other site 1306414009922 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1306414009923 Transcription factor WhiB; Region: Whib; pfam02467 1306414009924 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1306414009925 Transglycosylase; Region: Transgly; pfam00912 1306414009926 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1306414009927 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1306414009928 phosphodiesterase YaeI; Provisional; Region: PRK11340 1306414009929 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1306414009930 putative active site [active] 1306414009931 putative metal binding site [ion binding]; other site 1306414009932 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1306414009933 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1306414009934 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1306414009935 catalytic residue [active] 1306414009936 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1306414009937 Cytochrome P450; Region: p450; cl12078 1306414009938 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1306414009939 anti sigma factor interaction site; other site 1306414009940 regulatory phosphorylation site [posttranslational modification]; other site 1306414009941 Uncharacterized conserved protein [Function unknown]; Region: COG1610 1306414009942 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1306414009943 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 1306414009944 MoxR-like ATPases [General function prediction only]; Region: COG0714 1306414009945 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1306414009946 Walker A motif; other site 1306414009947 ATP binding site [chemical binding]; other site 1306414009948 Walker B motif; other site 1306414009949 arginine finger; other site 1306414009950 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1306414009951 Protein of unknown function DUF58; Region: DUF58; pfam01882 1306414009952 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 1306414009953 Predicted membrane protein/domain [Function unknown]; Region: COG1714 1306414009954 glycerol kinase; Provisional; Region: glpK; PRK00047 1306414009955 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1306414009956 nucleotide binding site [chemical binding]; other site 1306414009957 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1306414009958 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1306414009959 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1306414009960 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306414009961 S-adenosylmethionine binding site [chemical binding]; other site 1306414009962 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1306414009963 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1306414009964 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1306414009965 catalytic residue [active] 1306414009966 Uncharacterized conserved protein [Function unknown]; Region: COG4301 1306414009967 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 1306414009968 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 1306414009969 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1306414009970 putative active site [active] 1306414009971 putative dimer interface [polypeptide binding]; other site 1306414009972 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 1306414009973 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1306414009974 Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG3572 1306414009975 PknH-like extracellular domain; Region: PknH_C; pfam14032 1306414009976 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 1306414009977 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1306414009978 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1306414009979 aspartate kinase; Reviewed; Region: PRK06635 1306414009980 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1306414009981 putative nucleotide binding site [chemical binding]; other site 1306414009982 putative catalytic residues [active] 1306414009983 putative Mg ion binding site [ion binding]; other site 1306414009984 putative aspartate binding site [chemical binding]; other site 1306414009985 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1306414009986 putative allosteric regulatory site; other site 1306414009987 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1306414009988 putative allosteric regulatory residue; other site 1306414009989 2-isopropylmalate synthase; Validated; Region: PRK03739 1306414009990 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1306414009991 active site 1306414009992 catalytic residues [active] 1306414009993 metal binding site [ion binding]; metal-binding site 1306414009994 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1306414009995 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 1306414009996 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1306414009997 active site 1306414009998 catalytic site [active] 1306414009999 substrate binding site [chemical binding]; other site 1306414010000 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1306414010001 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1306414010002 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1306414010003 catalytic triad [active] 1306414010004 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1306414010005 putative active site [active] 1306414010006 recombination protein RecR; Reviewed; Region: recR; PRK00076 1306414010007 RecR protein; Region: RecR; pfam02132 1306414010008 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1306414010009 putative active site [active] 1306414010010 putative metal-binding site [ion binding]; other site 1306414010011 tetramer interface [polypeptide binding]; other site 1306414010012 hypothetical protein; Validated; Region: PRK00153 1306414010013 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1306414010014 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1306414010015 active site 1306414010016 metal binding site [ion binding]; metal-binding site 1306414010017 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 1306414010018 hydrophobic ligand binding site; other site 1306414010019 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1306414010020 FAD binding domain; Region: FAD_binding_4; pfam01565 1306414010021 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1306414010022 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306414010023 S-adenosylmethionine binding site [chemical binding]; other site 1306414010024 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14952 1306414010025 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1306414010026 Walker A motif; other site 1306414010027 ATP binding site [chemical binding]; other site 1306414010028 Walker B motif; other site 1306414010029 arginine finger; other site 1306414010030 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1306414010031 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 1306414010032 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1306414010033 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1306414010034 catalytic residue [active] 1306414010035 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1306414010036 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 1306414010037 putative NAD(P) binding site [chemical binding]; other site 1306414010038 catalytic Zn binding site [ion binding]; other site 1306414010039 Uncharacterized conserved protein [Function unknown]; Region: COG3349 1306414010040 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 1306414010041 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1306414010042 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1306414010043 putative substrate translocation pore; other site 1306414010044 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1306414010045 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1306414010046 ligand binding site [chemical binding]; other site 1306414010047 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1306414010048 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 1306414010049 active site 1306414010050 nucleophile elbow; other site 1306414010051 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 1306414010052 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1306414010053 FeS/SAM binding site; other site 1306414010054 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1306414010055 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306414010056 S-adenosylmethionine binding site [chemical binding]; other site 1306414010057 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 1306414010058 nucleotide binding site [chemical binding]; other site 1306414010059 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 1306414010060 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 1306414010061 active site 1306414010062 DNA binding site [nucleotide binding] 1306414010063 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 1306414010064 DNA binding site [nucleotide binding] 1306414010065 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4402 1306414010066 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_5; cd04662 1306414010067 nudix motif; other site 1306414010068 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1306414010069 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1306414010070 Uncharacterized conserved protein [Function unknown]; Region: COG1839 1306414010071 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1306414010072 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1306414010073 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1306414010074 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1306414010075 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1306414010076 Uncharacterized conserved protein [Function unknown]; Region: COG3610 1306414010077 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306414010078 PPE family; Region: PPE; pfam00823 1306414010079 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1306414010080 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1306414010081 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1306414010082 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1306414010083 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1306414010084 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1306414010085 dimerization interface [polypeptide binding]; other site 1306414010086 putative DNA binding site [nucleotide binding]; other site 1306414010087 putative Zn2+ binding site [ion binding]; other site 1306414010088 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3651 1306414010089 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 1306414010090 DNA binding domain, excisionase family; Region: excise; TIGR01764 1306414010091 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1306414010092 active site 1306414010093 Int/Topo IB signature motif; other site 1306414010094 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1306414010095 nucleoside/Zn binding site; other site 1306414010096 dimer interface [polypeptide binding]; other site 1306414010097 catalytic motif [active] 1306414010098 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 1306414010099 prephenate dehydrogenase; Validated; Region: PRK06545 1306414010100 prephenate dehydrogenase; Validated; Region: PRK08507 1306414010101 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3554 1306414010102 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1306414010103 ABC-ATPase subunit interface; other site 1306414010104 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 1306414010105 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1306414010106 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1306414010107 Walker A/P-loop; other site 1306414010108 ATP binding site [chemical binding]; other site 1306414010109 Q-loop/lid; other site 1306414010110 ABC transporter signature motif; other site 1306414010111 Walker B; other site 1306414010112 D-loop; other site 1306414010113 H-loop/switch region; other site 1306414010114 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1306414010115 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 1306414010116 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1306414010117 putative active site [active] 1306414010118 putative substrate binding site [chemical binding]; other site 1306414010119 ATP binding site [chemical binding]; other site 1306414010120 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 1306414010121 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1306414010122 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 1306414010123 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1306414010124 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1306414010125 dimerization interface [polypeptide binding]; other site 1306414010126 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1306414010127 dimer interface [polypeptide binding]; other site 1306414010128 phosphorylation site [posttranslational modification] 1306414010129 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1306414010130 ATP binding site [chemical binding]; other site 1306414010131 Mg2+ binding site [ion binding]; other site 1306414010132 G-X-G motif; other site 1306414010133 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1306414010134 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1306414010135 active site 1306414010136 phosphorylation site [posttranslational modification] 1306414010137 intermolecular recognition site; other site 1306414010138 dimerization interface [polypeptide binding]; other site 1306414010139 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1306414010140 DNA binding site [nucleotide binding] 1306414010141 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 1306414010142 active site 1306414010143 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1306414010144 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1306414010145 SnoaL-like domain; Region: SnoaL_2; pfam12680 1306414010146 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1306414010147 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1306414010148 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1306414010149 homodimer interface [polypeptide binding]; other site 1306414010150 catalytic residue [active] 1306414010151 enoyl-CoA hydratase; Provisional; Region: PRK06142 1306414010152 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1306414010153 substrate binding site [chemical binding]; other site 1306414010154 oxyanion hole (OAH) forming residues; other site 1306414010155 trimer interface [polypeptide binding]; other site 1306414010156 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1306414010157 Beta-lactamase; Region: Beta-lactamase; pfam00144 1306414010158 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1306414010159 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1306414010160 NAD(P) binding site [chemical binding]; other site 1306414010161 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1306414010162 cysteine desulfurase family protein, VC1184 subfamily; Region: am_tr_V_VC1184; TIGR01976 1306414010163 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1306414010164 catalytic residue [active] 1306414010165 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 1306414010166 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1306414010167 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1306414010168 Walker A/P-loop; other site 1306414010169 ATP binding site [chemical binding]; other site 1306414010170 Q-loop/lid; other site 1306414010171 ABC transporter signature motif; other site 1306414010172 Walker B; other site 1306414010173 D-loop; other site 1306414010174 H-loop/switch region; other site 1306414010175 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1306414010176 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1306414010177 active site 1306414010178 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1306414010179 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1306414010180 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1306414010181 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 1306414010182 NAD binding site [chemical binding]; other site 1306414010183 substrate binding site [chemical binding]; other site 1306414010184 active site 1306414010185 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1306414010186 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1306414010187 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05892 1306414010188 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1306414010189 Predicted membrane protein [Function unknown]; Region: COG2246 1306414010190 GtrA-like protein; Region: GtrA; pfam04138 1306414010191 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1306414010192 FAD binding domain; Region: FAD_binding_4; pfam01565 1306414010193 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1306414010194 short chain dehydrogenase; Provisional; Region: PRK07904 1306414010195 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1306414010196 NAD(P) binding site [chemical binding]; other site 1306414010197 active site 1306414010198 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 1306414010199 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 1306414010200 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1306414010201 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1306414010202 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1306414010203 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1306414010204 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 1306414010205 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306414010206 FAD binding site [chemical binding]; other site 1306414010207 substrate binding site [chemical binding]; other site 1306414010208 catalytic residues [active] 1306414010209 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1306414010210 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1306414010211 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1306414010212 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1306414010213 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1306414010214 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1306414010215 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1306414010216 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1306414010217 active site 1306414010218 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1306414010219 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1306414010220 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1306414010221 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1306414010222 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 1306414010223 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1306414010224 acyl-activating enzyme (AAE) consensus motif; other site 1306414010225 active site 1306414010226 Cutinase; Region: Cutinase; pfam01083 1306414010227 Predicted esterase [General function prediction only]; Region: COG0627 1306414010228 Putative esterase; Region: Esterase; pfam00756 1306414010229 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 1306414010230 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1306414010231 active site 1306414010232 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1306414010233 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1306414010234 active site 1306414010235 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 1306414010236 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1306414010237 UDP-galactopyranose mutase; Region: GLF; pfam03275 1306414010238 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1306414010239 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1306414010240 active site 1306414010241 motif I; other site 1306414010242 motif II; other site 1306414010243 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1306414010244 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1306414010245 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1306414010246 putative acyl-acceptor binding pocket; other site 1306414010247 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1306414010248 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1306414010249 putative acyl-acceptor binding pocket; other site 1306414010250 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1306414010251 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1306414010252 putative acyl-acceptor binding pocket; other site 1306414010253 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 1306414010254 Phosphotransferase enzyme family; Region: APH; pfam01636 1306414010255 active site 1306414010256 ATP binding site [chemical binding]; other site 1306414010257 antibiotic binding site [chemical binding]; other site 1306414010258 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1306414010259 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1306414010260 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1306414010261 iron-sulfur cluster [ion binding]; other site 1306414010262 [2Fe-2S] cluster binding site [ion binding]; other site 1306414010263 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1306414010264 PE-PPE domain; Region: PE-PPE; pfam08237 1306414010265 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1306414010266 Condensation domain; Region: Condensation; pfam00668 1306414010267 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1306414010268 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1306414010269 active site 1306414010270 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1306414010271 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1306414010272 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1306414010273 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1306414010274 Enoylreductase; Region: PKS_ER; smart00829 1306414010275 NAD(P) binding site [chemical binding]; other site 1306414010276 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1306414010277 KR domain; Region: KR; pfam08659 1306414010278 putative NADP binding site [chemical binding]; other site 1306414010279 active site 1306414010280 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1306414010281 acyl-CoA synthetase; Validated; Region: PRK05850 1306414010282 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1306414010283 acyl-activating enzyme (AAE) consensus motif; other site 1306414010284 active site 1306414010285 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1306414010286 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 1306414010287 catalytic residues [active] 1306414010288 catalytic nucleophile [active] 1306414010289 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1306414010290 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1306414010291 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1306414010292 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306414010293 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 1306414010294 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306414010295 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1306414010296 Cupin domain; Region: Cupin_2; cl17218 1306414010297 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1306414010298 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1306414010299 seryl-tRNA synthetase; Provisional; Region: PRK05431 1306414010300 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1306414010301 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1306414010302 dimer interface [polypeptide binding]; other site 1306414010303 active site 1306414010304 motif 1; other site 1306414010305 motif 2; other site 1306414010306 motif 3; other site 1306414010307 Septum formation; Region: Septum_form; pfam13845 1306414010308 Septum formation; Region: Septum_form; pfam13845 1306414010309 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1306414010310 catalytic core [active] 1306414010311 prephenate dehydratase; Provisional; Region: PRK11898 1306414010312 Prephenate dehydratase; Region: PDT; pfam00800 1306414010313 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1306414010314 putative L-Phe binding site [chemical binding]; other site 1306414010315 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1306414010316 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1306414010317 Ferritin-like domain; Region: Ferritin; pfam00210 1306414010318 ferroxidase diiron center [ion binding]; other site 1306414010319 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 1306414010320 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1306414010321 putative active site [active] 1306414010322 catalytic site [active] 1306414010323 putative metal binding site [ion binding]; other site 1306414010324 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 1306414010325 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1306414010326 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1306414010327 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1306414010328 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1306414010329 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1306414010330 Predicted membrane protein [Function unknown]; Region: COG2119 1306414010331 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1306414010332 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1306414010333 Fimbrial protein; Region: Fimbrial; cl01416 1306414010334 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1306414010335 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1306414010336 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1306414010337 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306414010338 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306414010339 hypothetical protein; Provisional; Region: PRK07945 1306414010340 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1306414010341 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 1306414010342 active site 1306414010343 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1306414010344 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1306414010345 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1306414010346 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1306414010347 active site 1306414010348 dimer interface [polypeptide binding]; other site 1306414010349 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1306414010350 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1306414010351 active site 1306414010352 FMN binding site [chemical binding]; other site 1306414010353 substrate binding site [chemical binding]; other site 1306414010354 3Fe-4S cluster binding site [ion binding]; other site 1306414010355 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1306414010356 domain interface; other site 1306414010357 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1306414010358 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1306414010359 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 1306414010360 EspG family; Region: ESX-1_EspG; pfam14011 1306414010361 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1306414010362 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1306414010363 Walker A motif; other site 1306414010364 ATP binding site [chemical binding]; other site 1306414010365 Walker B motif; other site 1306414010366 arginine finger; other site 1306414010367 Protein of unknown function (DUF690); Region: DUF690; pfam05108 1306414010368 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1306414010369 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1306414010370 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1306414010371 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1306414010372 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1306414010373 PE family; Region: PE; pfam00934 1306414010374 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306414010375 PPE family; Region: PPE; pfam00823 1306414010376 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1306414010377 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1306414010378 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1306414010379 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1306414010380 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 1306414010381 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1306414010382 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1306414010383 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1306414010384 active site 1306414010385 catalytic residues [active] 1306414010386 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1306414010387 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1306414010388 Walker A motif; other site 1306414010389 ATP binding site [chemical binding]; other site 1306414010390 Walker B motif; other site 1306414010391 arginine finger; other site 1306414010392 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1306414010393 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1306414010394 catalytic residues [active] 1306414010395 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1306414010396 active site 1306414010397 catalytic residues [active] 1306414010398 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1306414010399 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1306414010400 EspG family; Region: ESX-1_EspG; pfam14011 1306414010401 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1306414010402 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1306414010403 PPE family; Region: PPE; pfam00823 1306414010404 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1306414010405 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1306414010406 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1306414010407 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1306414010408 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1306414010409 Protein of unknown function (DUF690); Region: DUF690; pfam05108 1306414010410 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1306414010411 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1306414010412 catalytic residue [active] 1306414010413 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 1306414010414 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1306414010415 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 1306414010416 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1306414010417 active site 1306414010418 NTP binding site [chemical binding]; other site 1306414010419 metal binding triad [ion binding]; metal-binding site 1306414010420 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1306414010421 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1306414010422 Zn2+ binding site [ion binding]; other site 1306414010423 Mg2+ binding site [ion binding]; other site 1306414010424 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1306414010425 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1306414010426 active site 1306414010427 Ap6A binding site [chemical binding]; other site 1306414010428 nudix motif; other site 1306414010429 metal binding site [ion binding]; metal-binding site 1306414010430 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1306414010431 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1306414010432 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1306414010433 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1306414010434 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1306414010435 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1306414010436 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1306414010437 catalytic residues [active] 1306414010438 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1306414010439 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1306414010440 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1306414010441 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1306414010442 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1306414010443 active site 1306414010444 metal binding site [ion binding]; metal-binding site 1306414010445 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1306414010446 ParB-like nuclease domain; Region: ParB; smart00470 1306414010447 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1306414010448 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1306414010449 P-loop; other site 1306414010450 Magnesium ion binding site [ion binding]; other site 1306414010451 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1306414010452 Magnesium ion binding site [ion binding]; other site 1306414010453 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 1306414010454 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1306414010455 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1306414010456 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1306414010457 G-X-X-G motif; other site 1306414010458 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1306414010459 RxxxH motif; other site 1306414010460 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 1306414010461 Uncharacterized conserved protein [Function unknown]; Region: COG0759 1306414010462 ribonuclease P; Reviewed; Region: rnpA; PRK00588 1306414010463 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399