-- dump date 20140619_154431 -- class Genbank::misc_feature -- table misc_feature_note -- id note 652616000001 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 652616000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 652616000003 Walker A motif; other site 652616000004 ATP binding site [chemical binding]; other site 652616000005 Walker B motif; other site 652616000006 arginine finger; other site 652616000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 652616000008 DnaA box-binding interface [nucleotide binding]; other site 652616000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 652616000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 652616000011 putative DNA binding surface [nucleotide binding]; other site 652616000012 dimer interface [polypeptide binding]; other site 652616000013 beta-clamp/clamp loader binding surface; other site 652616000014 beta-clamp/translesion DNA polymerase binding surface; other site 652616000015 recF protein; Region: recf; TIGR00611 652616000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 652616000017 Walker A/P-loop; other site 652616000018 ATP binding site [chemical binding]; other site 652616000019 Q-loop/lid; other site 652616000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 652616000021 ABC transporter signature motif; other site 652616000022 Walker B; other site 652616000023 D-loop; other site 652616000024 H-loop/switch region; other site 652616000025 hypothetical protein; Provisional; Region: PRK03195 652616000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 652616000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 652616000028 Mg2+ binding site [ion binding]; other site 652616000029 G-X-G motif; other site 652616000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 652616000031 anchoring element; other site 652616000032 dimer interface [polypeptide binding]; other site 652616000033 ATP binding site [chemical binding]; other site 652616000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 652616000035 active site 652616000036 putative metal-binding site [ion binding]; other site 652616000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 652616000038 DNA gyrase subunit A; Validated; Region: PRK05560 652616000039 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 652616000040 CAP-like domain; other site 652616000041 active site 652616000042 primary dimer interface [polypeptide binding]; other site 652616000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 652616000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 652616000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 652616000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 652616000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 652616000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 652616000049 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 652616000050 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 652616000051 Protein of unknown function (DUF2562); Region: DUF2562; pfam10814 652616000052 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 652616000053 active site 652616000054 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 652616000055 putative septation inhibitor protein; Reviewed; Region: PRK00159 652616000056 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 652616000057 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 652616000058 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 652616000059 Glutamine amidotransferase class-I; Region: GATase; pfam00117 652616000060 glutamine binding [chemical binding]; other site 652616000061 catalytic triad [active] 652616000062 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 652616000063 Catalytic domain of Protein Kinases; Region: PKc; cd00180 652616000064 active site 652616000065 ATP binding site [chemical binding]; other site 652616000066 substrate binding site [chemical binding]; other site 652616000067 activation loop (A-loop); other site 652616000068 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 652616000069 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 652616000070 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 652616000071 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 652616000072 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 652616000073 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 652616000074 Catalytic domain of Protein Kinases; Region: PKc; cd00180 652616000075 active site 652616000076 ATP binding site [chemical binding]; other site 652616000077 substrate binding site [chemical binding]; other site 652616000078 activation loop (A-loop); other site 652616000079 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 652616000080 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 652616000081 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 652616000082 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 652616000083 active site 652616000084 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 652616000085 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 652616000086 phosphopeptide binding site; other site 652616000087 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 652616000088 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 652616000089 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 652616000090 phosphopeptide binding site; other site 652616000091 Nitronate monooxygenase; Region: NMO; pfam03060 652616000092 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 652616000093 FMN binding site [chemical binding]; other site 652616000094 substrate binding site [chemical binding]; other site 652616000095 putative catalytic residue [active] 652616000096 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 652616000097 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 652616000098 non-specific DNA binding site [nucleotide binding]; other site 652616000099 salt bridge; other site 652616000100 sequence-specific DNA binding site [nucleotide binding]; other site 652616000101 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 652616000102 NlpC/P60 family; Region: NLPC_P60; pfam00877 652616000103 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 652616000104 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 652616000105 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 652616000106 Protein of unknown function (DUF2694); Region: DUF2694; pfam10904 652616000107 Protein of unknown function (DUF2710); Region: DUF2710; pfam10921 652616000108 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 652616000109 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 652616000110 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 652616000111 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 652616000112 catalytic residue [active] 652616000113 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 652616000114 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 652616000115 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 652616000116 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 652616000117 acyl-activating enzyme (AAE) consensus motif; other site 652616000118 active site 652616000119 TIGR03084 family protein; Region: TIGR03084 652616000120 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 652616000121 Wyosine base formation; Region: Wyosine_form; pfam08608 652616000122 H+ Antiporter protein; Region: 2A0121; TIGR00900 652616000123 hypothetical protein; Validated; Region: PRK00228 652616000124 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 652616000125 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 652616000126 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 652616000127 active site 652616000128 HIGH motif; other site 652616000129 nucleotide binding site [chemical binding]; other site 652616000130 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 652616000131 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 652616000132 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 652616000133 active site 652616000134 KMSKS motif; other site 652616000135 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 652616000136 tRNA binding surface [nucleotide binding]; other site 652616000137 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 652616000138 MarR family; Region: MarR; pfam01047 652616000139 Transcriptional regulators [Transcription]; Region: FadR; COG2186 652616000140 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 652616000141 DNA-binding site [nucleotide binding]; DNA binding site 652616000142 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 652616000143 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 652616000144 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 652616000145 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 652616000146 inositol 1-phosphate synthase, Actinobacterial type; Region: mycothiol_INO1; TIGR03450 652616000147 Predicted transcriptional regulators [Transcription]; Region: COG1695 652616000148 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 652616000149 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 652616000150 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 652616000151 Transglycosylase; Region: Transgly; pfam00912 652616000152 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 652616000153 Predicted integral membrane protein [Function unknown]; Region: COG5650 652616000154 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 652616000155 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 652616000156 conserved cys residue [active] 652616000157 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 652616000158 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 652616000159 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 652616000160 dimer interface [polypeptide binding]; other site 652616000161 ssDNA binding site [nucleotide binding]; other site 652616000162 tetramer (dimer of dimers) interface [polypeptide binding]; other site 652616000163 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 652616000164 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 652616000165 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 652616000166 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 652616000167 replicative DNA helicase; Validated; Region: PRK07773 652616000168 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 652616000169 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 652616000170 Walker A motif; other site 652616000171 ATP binding site [chemical binding]; other site 652616000172 Walker B motif; other site 652616000173 DNA binding loops [nucleotide binding] 652616000174 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 652616000175 protein-splicing catalytic site; other site 652616000176 thioester formation/cholesterol transfer; other site 652616000177 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 652616000178 protein-splicing catalytic site; other site 652616000179 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 652616000180 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 652616000181 ADP-ribose binding site [chemical binding]; other site 652616000182 Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1 [General function prediction only]; Region: COG2110 652616000183 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 652616000184 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 652616000185 FAD binding domain; Region: FAD_binding_4; pfam01565 652616000186 Berberine and berberine like; Region: BBE; pfam08031 652616000187 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 652616000188 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 652616000189 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 652616000190 homotetrameric interface [polypeptide binding]; other site 652616000191 putative active site [active] 652616000192 metal binding site [ion binding]; metal-binding site 652616000193 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 652616000194 Monomeric isocitrate dehydrogenase; Region: IDH; pfam03971 652616000195 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 652616000196 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 652616000197 short chain dehydrogenase; Provisional; Region: PRK06197 652616000198 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 652616000199 putative NAD(P) binding site [chemical binding]; other site 652616000200 active site 652616000201 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 652616000202 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 652616000203 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 652616000204 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 652616000205 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 652616000206 dimer interface [polypeptide binding]; other site 652616000207 active site 652616000208 glycine-pyridoxal phosphate binding site [chemical binding]; other site 652616000209 folate binding site [chemical binding]; other site 652616000210 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 652616000211 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 652616000212 putative NTP binding site [chemical binding]; other site 652616000213 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 652616000214 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 652616000215 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 652616000216 Walker A/P-loop; other site 652616000217 ATP binding site [chemical binding]; other site 652616000218 Q-loop/lid; other site 652616000219 ABC transporter signature motif; other site 652616000220 Walker B; other site 652616000221 D-loop; other site 652616000222 H-loop/switch region; other site 652616000223 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 652616000224 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 652616000225 ligand binding site [chemical binding]; other site 652616000226 flexible hinge region; other site 652616000227 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 652616000228 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 652616000229 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 652616000230 active site 652616000231 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 652616000232 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 652616000233 pyridoxal 5'-phosphate binding site [chemical binding]; other site 652616000234 homodimer interface [polypeptide binding]; other site 652616000235 catalytic residue [active] 652616000236 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 652616000237 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 652616000238 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 652616000239 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 652616000240 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 652616000241 dimerization interface [polypeptide binding]; other site 652616000242 putative DNA binding site [nucleotide binding]; other site 652616000243 putative Zn2+ binding site [ion binding]; other site 652616000244 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 652616000245 hydrogenase 4 subunit B; Validated; Region: PRK06521 652616000246 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 652616000247 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 652616000248 NADH dehydrogenase; Region: NADHdh; cl00469 652616000249 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; COG4237 652616000250 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 652616000251 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 652616000252 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 652616000253 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 652616000254 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 652616000255 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 652616000256 putative hydrophobic ligand binding site [chemical binding]; other site 652616000257 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 652616000258 S-adenosylmethionine binding site [chemical binding]; other site 652616000259 Predicted membrane protein [Function unknown]; Region: COG3305 652616000260 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 652616000261 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 652616000262 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 652616000263 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 652616000264 Soluble P-type ATPase [General function prediction only]; Region: COG4087 652616000265 Domain of unknown function (DUF222); Region: DUF222; pfam02720 652616000266 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 652616000267 active site 652616000268 Domain of unknown function (DUF222); Region: DUF222; pfam02720 652616000269 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616000270 PPE family; Region: PPE; pfam00823 652616000271 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 652616000272 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 652616000273 FcoT-like thioesterase domain; Region: FcoT; pfam10862 652616000274 acyl-CoA synthetase; Validated; Region: PRK05857 652616000275 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 652616000276 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 652616000277 acyl-activating enzyme (AAE) consensus motif; other site 652616000278 acyl-activating enzyme (AAE) consensus motif; other site 652616000279 AMP binding site [chemical binding]; other site 652616000280 active site 652616000281 CoA binding site [chemical binding]; other site 652616000282 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 652616000283 AMP-binding enzyme; Region: AMP-binding; pfam00501 652616000284 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 652616000285 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 652616000286 acyl-activating enzyme (AAE) consensus motif; other site 652616000287 acyl-activating enzyme (AAE) consensus motif; other site 652616000288 active site 652616000289 AMP binding site [chemical binding]; other site 652616000290 CoA binding site [chemical binding]; other site 652616000291 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 652616000292 Condensation domain; Region: Condensation; pfam00668 652616000293 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 652616000294 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 652616000295 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 652616000296 acyl-activating enzyme (AAE) consensus motif; other site 652616000297 AMP binding site [chemical binding]; other site 652616000298 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 652616000299 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 652616000300 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 652616000301 putative NAD(P) binding site [chemical binding]; other site 652616000302 active site 652616000303 putative substrate binding site [chemical binding]; other site 652616000304 Predicted membrane protein [Function unknown]; Region: COG3336 652616000305 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 652616000306 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 652616000307 metal-binding site [ion binding] 652616000308 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 652616000309 Soluble P-type ATPase [General function prediction only]; Region: COG4087 652616000310 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 652616000311 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 652616000312 ligand binding site [chemical binding]; other site 652616000313 flexible hinge region; other site 652616000314 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 652616000315 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 652616000316 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 652616000317 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 652616000318 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 652616000319 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 652616000320 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 652616000321 motif II; other site 652616000322 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 652616000323 PE family; Region: PE; pfam00934 652616000324 Rhomboid family; Region: Rhomboid; pfam01694 652616000325 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 652616000326 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 652616000327 active site 652616000328 catalytic triad [active] 652616000329 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 652616000330 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 652616000331 NADP-binding site; other site 652616000332 homotetramer interface [polypeptide binding]; other site 652616000333 substrate binding site [chemical binding]; other site 652616000334 homodimer interface [polypeptide binding]; other site 652616000335 active site 652616000336 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 652616000337 dimer interface [polypeptide binding]; other site 652616000338 active site 652616000339 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 652616000340 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 652616000341 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 652616000342 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 652616000343 Transcriptional regulator [Transcription]; Region: LysR; COG0583 652616000344 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 652616000345 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 652616000346 dimerization interface [polypeptide binding]; other site 652616000347 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 652616000348 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 652616000349 PYR/PP interface [polypeptide binding]; other site 652616000350 dimer interface [polypeptide binding]; other site 652616000351 TPP binding site [chemical binding]; other site 652616000352 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 652616000353 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 652616000354 TPP-binding site; other site 652616000355 dimer interface [polypeptide binding]; other site 652616000356 acyl-CoA synthetase; Validated; Region: PRK05852 652616000357 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 652616000358 Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926 652616000359 acyl-activating enzyme (AAE) consensus motif; other site 652616000360 acyl-activating enzyme (AAE) consensus motif; other site 652616000361 putative AMP binding site [chemical binding]; other site 652616000362 putative active site [active] 652616000363 putative CoA binding site [chemical binding]; other site 652616000364 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 652616000365 elongation factor G; Reviewed; Region: PRK12740 652616000366 G1 box; other site 652616000367 putative GEF interaction site [polypeptide binding]; other site 652616000368 GTP/Mg2+ binding site [chemical binding]; other site 652616000369 Switch I region; other site 652616000370 G2 box; other site 652616000371 G3 box; other site 652616000372 Switch II region; other site 652616000373 G4 box; other site 652616000374 G5 box; other site 652616000375 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 652616000376 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 652616000377 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 652616000378 PPOX class probable F420-dependent enzyme, Rv0121 family; Region: Rv0121_F420; TIGR03668 652616000379 PE family; Region: PE; pfam00934 652616000380 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 652616000381 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 652616000382 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 652616000383 trehalose synthase; Region: treS_nterm; TIGR02456 652616000384 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 652616000385 active site 652616000386 catalytic site [active] 652616000387 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 652616000388 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 652616000389 Predicted membrane protein [Function unknown]; Region: COG3619 652616000390 Predicted esterase [General function prediction only]; Region: COG0627 652616000391 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 652616000392 putative active site [active] 652616000393 putative catalytic site [active] 652616000394 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 652616000395 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 652616000396 active site 652616000397 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 652616000398 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 652616000399 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 652616000400 Coenzyme A binding pocket [chemical binding]; other site 652616000401 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 652616000402 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 652616000403 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 652616000404 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 652616000405 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 652616000406 Cytochrome P450; Region: p450; cl12078 652616000407 methionine sulfoxide reductase A; Provisional; Region: PRK14054 652616000408 SnoaL-like domain; Region: SnoaL_2; pfam12680 652616000409 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 652616000410 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 652616000411 NAD(P) binding site [chemical binding]; other site 652616000412 active site 652616000413 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 652616000414 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 652616000415 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 652616000416 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 652616000417 minor groove reading motif; other site 652616000418 helix-hairpin-helix signature motif; other site 652616000419 active site 652616000420 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 652616000421 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 652616000422 Cl- selectivity filter; other site 652616000423 Cl- binding residues [ion binding]; other site 652616000424 pore gating glutamate residue; other site 652616000425 dimer interface [polypeptide binding]; other site 652616000426 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 652616000427 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 652616000428 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 652616000429 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 652616000430 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 652616000431 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 652616000432 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 652616000433 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 652616000434 NAD(P) binding site [chemical binding]; other site 652616000435 catalytic residues [active] 652616000436 short chain dehydrogenase; Provisional; Region: PRK07791 652616000437 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 652616000438 NAD binding site [chemical binding]; other site 652616000439 homodimer interface [polypeptide binding]; other site 652616000440 active site 652616000441 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 652616000442 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 652616000443 NAD(P) binding site [chemical binding]; other site 652616000444 PE family; Region: PE; pfam00934 652616000445 PE-PPE domain; Region: PE-PPE; pfam08237 652616000446 PE-PPE domain; Region: PE-PPE; pfam08237 652616000447 PE family; Region: PE; pfam00934 652616000448 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 652616000449 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 652616000450 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 652616000451 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 652616000452 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 652616000453 FAD binding site [chemical binding]; other site 652616000454 substrate binding site [chemical binding]; other site 652616000455 catalytic base [active] 652616000456 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 652616000457 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 652616000458 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 652616000459 ligand binding site [chemical binding]; other site 652616000460 homodimer interface [polypeptide binding]; other site 652616000461 NAD(P) binding site [chemical binding]; other site 652616000462 trimer interface B [polypeptide binding]; other site 652616000463 trimer interface A [polypeptide binding]; other site 652616000464 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 652616000465 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 652616000466 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 652616000467 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 652616000468 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 652616000469 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 652616000470 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 652616000471 PE family; Region: PE; pfam00934 652616000472 PE-PPE domain; Region: PE-PPE; pfam08237 652616000473 PE family; Region: PE; pfam00934 652616000474 PE-PPE domain; Region: PE-PPE; pfam08237 652616000475 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 652616000476 FAD binding domain; Region: FAD_binding_4; pfam01565 652616000477 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 652616000478 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 652616000479 NAD(P) binding site [chemical binding]; other site 652616000480 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 652616000481 active site 652616000482 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 652616000483 putative hydrophobic ligand binding site [chemical binding]; other site 652616000484 Transcriptional regulators [Transcription]; Region: GntR; COG1802 652616000485 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 652616000486 DNA-binding site [nucleotide binding]; DNA binding site 652616000487 FCD domain; Region: FCD; cl11656 652616000488 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786 652616000489 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 652616000490 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 652616000491 acyl-activating enzyme (AAE) consensus motif; other site 652616000492 acyl-activating enzyme (AAE) consensus motif; other site 652616000493 putative AMP binding site [chemical binding]; other site 652616000494 putative active site [active] 652616000495 putative CoA binding site [chemical binding]; other site 652616000496 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 652616000497 Permease; Region: Permease; pfam02405 652616000498 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 652616000499 Permease; Region: Permease; pfam02405 652616000500 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 652616000501 mce related protein; Region: MCE; pfam02470 652616000502 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 652616000503 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 652616000504 mce related protein; Region: MCE; pfam02470 652616000505 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 652616000506 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 652616000507 mce related protein; Region: MCE; pfam02470 652616000508 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 652616000509 mce related protein; Region: MCE; pfam02470 652616000510 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 652616000511 mce related protein; Region: MCE; pfam02470 652616000512 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 652616000513 mce related protein; Region: MCE; pfam02470 652616000514 RDD family; Region: RDD; pfam06271 652616000515 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 652616000516 Predicted membrane protein [Function unknown]; Region: COG1511 652616000517 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 652616000518 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 652616000519 Pirin-related protein [General function prediction only]; Region: COG1741 652616000520 Pirin; Region: Pirin; pfam02678 652616000521 RNA polymerase factor sigma-70; Validated; Region: PRK08241 652616000522 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 652616000523 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 652616000524 DNA binding residues [nucleotide binding] 652616000525 SnoaL-like domain; Region: SnoaL_2; pfam12680 652616000526 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 652616000527 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 652616000528 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 652616000529 putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185 652616000530 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 652616000531 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 652616000532 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 652616000533 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 652616000534 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 652616000535 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 652616000536 S-adenosylmethionine binding site [chemical binding]; other site 652616000537 SPW repeat; Region: SPW; pfam03779 652616000538 SPW repeat; Region: SPW; pfam03779 652616000539 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 652616000540 6-phosphogluconate dehydratase; Region: edd; TIGR01196 652616000541 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 652616000542 putative homodimer interface [polypeptide binding]; other site 652616000543 putative homotetramer interface [polypeptide binding]; other site 652616000544 putative allosteric switch controlling residues; other site 652616000545 putative metal binding site [ion binding]; other site 652616000546 putative homodimer-homodimer interface [polypeptide binding]; other site 652616000547 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 652616000548 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 652616000549 putative substrate translocation pore; other site 652616000550 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 652616000551 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 652616000552 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 652616000553 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 652616000554 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 652616000555 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 652616000556 Walker A/P-loop; other site 652616000557 ATP binding site [chemical binding]; other site 652616000558 Q-loop/lid; other site 652616000559 ABC transporter signature motif; other site 652616000560 Walker B; other site 652616000561 D-loop; other site 652616000562 H-loop/switch region; other site 652616000563 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 652616000564 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 652616000565 Walker A/P-loop; other site 652616000566 ATP binding site [chemical binding]; other site 652616000567 Q-loop/lid; other site 652616000568 ABC transporter signature motif; other site 652616000569 Walker B; other site 652616000570 D-loop; other site 652616000571 H-loop/switch region; other site 652616000572 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 652616000573 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 652616000574 dimerization interface [polypeptide binding]; other site 652616000575 DNA binding residues [nucleotide binding] 652616000576 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 652616000577 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 652616000578 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 652616000579 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 652616000580 putative [Fe4-S4] binding site [ion binding]; other site 652616000581 putative molybdopterin cofactor binding site [chemical binding]; other site 652616000582 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 652616000583 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 652616000584 putative molybdopterin cofactor binding site; other site 652616000585 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 652616000586 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 652616000587 active site 652616000588 Zn binding site [ion binding]; other site 652616000589 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 652616000590 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 652616000591 Predicted integral membrane protein [Function unknown]; Region: COG0392 652616000592 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 652616000593 Domain of unknown function DUF20; Region: UPF0118; pfam01594 652616000594 MMPL family; Region: MMPL; pfam03176 652616000595 MMPL family; Region: MMPL; pfam03176 652616000596 LabA_like proteins; Region: LabA_like; cd06167 652616000597 putative metal binding site [ion binding]; other site 652616000598 Putative methyltransferase; Region: Methyltransf_4; pfam02390 652616000599 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 652616000600 active site 652616000601 substrate-binding site [chemical binding]; other site 652616000602 metal-binding site [ion binding] 652616000603 GTP binding site [chemical binding]; other site 652616000604 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 652616000605 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 652616000606 active site 652616000607 (T/H)XGH motif; other site 652616000608 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 652616000609 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 652616000610 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 652616000611 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 652616000612 FeS/SAM binding site; other site 652616000613 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 652616000614 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 652616000615 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 652616000616 acyl-activating enzyme (AAE) consensus motif; other site 652616000617 acyl-activating enzyme (AAE) consensus motif; other site 652616000618 putative AMP binding site [chemical binding]; other site 652616000619 putative active site [active] 652616000620 putative CoA binding site [chemical binding]; other site 652616000621 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 652616000622 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 652616000623 active site 652616000624 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 652616000625 putative active site [active] 652616000626 putative catalytic site [active] 652616000627 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 652616000628 active site 2 [active] 652616000629 active site 1 [active] 652616000630 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 652616000631 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 652616000632 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 652616000633 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321 652616000634 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 652616000635 Moco binding site; other site 652616000636 metal coordination site [ion binding]; other site 652616000637 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 652616000638 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 652616000639 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 652616000640 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 652616000641 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 652616000642 enoyl-CoA hydratase; Provisional; Region: PRK08252 652616000643 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 652616000644 substrate binding site [chemical binding]; other site 652616000645 oxyanion hole (OAH) forming residues; other site 652616000646 trimer interface [polypeptide binding]; other site 652616000647 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 652616000648 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 652616000649 NAD binding site [chemical binding]; other site 652616000650 catalytic residues [active] 652616000651 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 652616000652 S-adenosylmethionine binding site [chemical binding]; other site 652616000653 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 652616000654 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 652616000655 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 652616000656 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 652616000657 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 652616000658 putative active site [active] 652616000659 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 652616000660 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 652616000661 active site 652616000662 substrate binding pocket [chemical binding]; other site 652616000663 homodimer interaction site [polypeptide binding]; other site 652616000664 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 652616000665 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 652616000666 active site 652616000667 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 652616000668 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 652616000669 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 652616000670 active site 652616000671 diiron metal binding site [ion binding]; other site 652616000672 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 652616000673 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 652616000674 NAD(P) binding site [chemical binding]; other site 652616000675 catalytic residues [active] 652616000676 Lipase maturation factor; Region: LMF1; pfam06762 652616000677 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 652616000678 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 652616000679 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 652616000680 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 652616000681 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 652616000682 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 652616000683 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 652616000684 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 652616000685 MaoC like domain; Region: MaoC_dehydratas; pfam01575 652616000686 active site 2 [active] 652616000687 active site 1 [active] 652616000688 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 652616000689 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 652616000690 NAD(P) binding site [chemical binding]; other site 652616000691 active site 652616000692 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 652616000693 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 652616000694 dimer interface [polypeptide binding]; other site 652616000695 active site 652616000696 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 652616000697 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 652616000698 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 652616000699 FAD binding site [chemical binding]; other site 652616000700 substrate binding site [chemical binding]; other site 652616000701 catalytic residues [active] 652616000702 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 652616000703 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 652616000704 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 652616000705 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 652616000706 catalytic loop [active] 652616000707 iron binding site [ion binding]; other site 652616000708 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 652616000709 L-aspartate oxidase; Provisional; Region: PRK06175 652616000710 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 652616000711 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 652616000712 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 652616000713 putative dimer interface [polypeptide binding]; other site 652616000714 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 652616000715 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 652616000716 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 652616000717 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 652616000718 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 652616000719 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 652616000720 homotrimer interface [polypeptide binding]; other site 652616000721 Walker A motif; other site 652616000722 GTP binding site [chemical binding]; other site 652616000723 Walker B motif; other site 652616000724 cobyric acid synthase; Provisional; Region: PRK00784 652616000725 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 652616000726 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 652616000727 catalytic triad [active] 652616000728 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616000729 PPE family; Region: PPE; pfam00823 652616000730 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 652616000731 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 652616000732 putative active site [active] 652616000733 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 652616000734 putative active site [active] 652616000735 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 652616000736 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 652616000737 active site 652616000738 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 652616000739 DNA binding site [nucleotide binding] 652616000740 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 652616000741 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 652616000742 Coenzyme A binding pocket [chemical binding]; other site 652616000743 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 652616000744 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 652616000745 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 652616000746 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 652616000747 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 652616000748 intersubunit interface [polypeptide binding]; other site 652616000749 5-oxoprolinase; Region: PLN02666 652616000750 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 652616000751 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 652616000752 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 652616000753 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 652616000754 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 652616000755 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 652616000756 nucleotide binding site [chemical binding]; other site 652616000757 acyl-CoA synthetase; Validated; Region: PRK07788 652616000758 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 652616000759 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 652616000760 active site 652616000761 CoA binding site [chemical binding]; other site 652616000762 AMP binding site [chemical binding]; other site 652616000763 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 652616000764 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 652616000765 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 652616000766 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 652616000767 FAD binding site [chemical binding]; other site 652616000768 substrate binding site [chemical binding]; other site 652616000769 catalytic base [active] 652616000770 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 652616000771 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 652616000772 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 652616000773 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 652616000774 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 652616000775 putative active site [active] 652616000776 PE family; Region: PE; pfam00934 652616000777 PE family; Region: PE; pfam00934 652616000778 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616000779 PPE family; Region: PPE; pfam00823 652616000780 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616000781 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 652616000782 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 652616000783 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 652616000784 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 652616000785 Walker A motif; other site 652616000786 ATP binding site [chemical binding]; other site 652616000787 Walker B motif; other site 652616000788 arginine finger; other site 652616000789 Protein of unknown function (DUF690); Region: DUF690; pfam05108 652616000790 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 652616000791 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 652616000792 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 652616000793 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 652616000794 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 652616000795 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616000796 PPE family; Region: PPE; pfam00823 652616000797 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 652616000798 EspG family; Region: ESX-1_EspG; pfam14011 652616000799 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 652616000800 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 652616000801 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 652616000802 active site 652616000803 catalytic residues [active] 652616000804 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 652616000805 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 652616000806 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 652616000807 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 652616000808 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 652616000809 S-adenosylmethionine binding site [chemical binding]; other site 652616000810 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4424 652616000811 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 652616000812 Sulfatase; Region: Sulfatase; cl17466 652616000813 hypothetical protein; Region: PHA01748 652616000814 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 652616000815 putative active site [active] 652616000816 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 652616000817 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 652616000818 light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs; Region: LPOR_like_SDR_c_like; cd09810 652616000819 protochlorophyllide reductase; Region: PLN00015 652616000820 putative NAD(P) binding site [chemical binding]; other site 652616000821 active site 652616000822 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616000823 PPE family; Region: PPE; pfam00823 652616000824 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616000825 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 652616000826 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616000827 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 652616000828 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 652616000829 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616000830 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 652616000831 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 652616000832 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616000833 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 652616000834 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 652616000835 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 652616000836 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 652616000837 putative FMN binding site [chemical binding]; other site 652616000838 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 652616000839 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 652616000840 active site 652616000841 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 652616000842 SnoaL-like domain; Region: SnoaL_4; pfam13577 652616000843 SnoaL-like domain; Region: SnoaL_3; pfam13474 652616000844 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 652616000845 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 652616000846 nucleotide binding site [chemical binding]; other site 652616000847 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]; Region: HtpG; COG0326 652616000848 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 652616000849 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 652616000850 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 652616000851 active site 652616000852 catalytic residues [active] 652616000853 Muconolactone delta-isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CatC1; COG4829 652616000854 Muconolactone delta-isomerase; Region: MIase; cl01992 652616000855 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 652616000856 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 652616000857 putative active site [active] 652616000858 putative metal binding site [ion binding]; other site 652616000859 catalytic site [active] 652616000860 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 652616000861 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 652616000862 putative substrate binding pocket [chemical binding]; other site 652616000863 AC domain interface; other site 652616000864 catalytic triad [active] 652616000865 AB domain interface; other site 652616000866 interchain disulfide; other site 652616000867 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 652616000868 trimer interface [polypeptide binding]; other site 652616000869 active site 652616000870 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 652616000871 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 652616000872 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 652616000873 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 652616000874 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 652616000875 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 652616000876 dimerization interface [polypeptide binding]; other site 652616000877 putative DNA binding site [nucleotide binding]; other site 652616000878 putative Zn2+ binding site [ion binding]; other site 652616000879 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 652616000880 active site residue [active] 652616000881 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 652616000882 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 652616000883 Cytochrome P450; Region: p450; cl12078 652616000884 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 652616000885 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 652616000886 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 652616000887 Methyltransferase domain; Region: Methyltransf_23; pfam13489 652616000888 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 652616000889 S-adenosylmethionine binding site [chemical binding]; other site 652616000890 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 652616000891 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 652616000892 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 652616000893 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 652616000894 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 652616000895 SnoaL-like domain; Region: SnoaL_2; pfam12680 652616000896 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 652616000897 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 652616000898 substrate binding site; other site 652616000899 tetramer interface; other site 652616000900 PE family; Region: PE; pfam00934 652616000901 Domain of unknown function (DUF222); Region: DUF222; pfam02720 652616000902 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 652616000903 active site 652616000904 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 652616000905 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 652616000906 pyridoxal 5'-phosphate binding site [chemical binding]; other site 652616000907 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 652616000908 4Fe-4S binding domain; Region: Fer4; pfam00037 652616000909 Cysteine-rich domain; Region: CCG; pfam02754 652616000910 Cysteine-rich domain; Region: CCG; pfam02754 652616000911 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 652616000912 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 652616000913 DNA binding residues [nucleotide binding] 652616000914 dimerization interface [polypeptide binding]; other site 652616000915 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 652616000916 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 652616000917 G1 box; other site 652616000918 GTP/Mg2+ binding site [chemical binding]; other site 652616000919 G2 box; other site 652616000920 Switch I region; other site 652616000921 G3 box; other site 652616000922 Switch II region; other site 652616000923 G4 box; other site 652616000924 G5 box; other site 652616000925 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 652616000926 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 652616000927 G1 box; other site 652616000928 GTP/Mg2+ binding site [chemical binding]; other site 652616000929 G2 box; other site 652616000930 Switch I region; other site 652616000931 G3 box; other site 652616000932 Switch II region; other site 652616000933 Uncharacterized MobA-related protein [General function prediction only]; Region: COG2068 652616000934 active site 652616000935 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 652616000936 TIGR04255 family protein; Region: sporadTIGR04255 652616000937 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 652616000938 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 652616000939 nucleotide binding site [chemical binding]; other site 652616000940 NEF interaction site [polypeptide binding]; other site 652616000941 SBD interface [polypeptide binding]; other site 652616000942 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 652616000943 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 652616000944 dimer interface [polypeptide binding]; other site 652616000945 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 652616000946 chaperone protein DnaJ; Provisional; Region: PRK14279 652616000947 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 652616000948 HSP70 interaction site [polypeptide binding]; other site 652616000949 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 652616000950 Zn binding sites [ion binding]; other site 652616000951 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 652616000952 dimer interface [polypeptide binding]; other site 652616000953 Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279 652616000954 DNA binding residues [nucleotide binding] 652616000955 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 652616000956 putative dimer interface [polypeptide binding]; other site 652616000957 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616000958 PPE family; Region: PPE; pfam00823 652616000959 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 652616000960 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616000961 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616000962 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616000963 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 652616000964 CoenzymeA binding site [chemical binding]; other site 652616000965 subunit interaction site [polypeptide binding]; other site 652616000966 PHB binding site; other site 652616000967 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 652616000968 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 652616000969 GDP-binding site [chemical binding]; other site 652616000970 ACT binding site; other site 652616000971 IMP binding site; other site 652616000972 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 652616000973 Peptidase family M50; Region: Peptidase_M50; pfam02163 652616000974 active site 652616000975 putative substrate binding region [chemical binding]; other site 652616000976 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 652616000977 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 652616000978 MgtE intracellular N domain; Region: MgtE_N; pfam03448 652616000979 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 652616000980 Divalent cation transporter; Region: MgtE; pfam01769 652616000981 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 652616000982 fructose-bisphosphate aldolase, class II, yeast/E. coli subtype; Region: FruBisAldo_II_A; TIGR01520 652616000983 active site 652616000984 intersubunit interface [polypeptide binding]; other site 652616000985 zinc binding site [ion binding]; other site 652616000986 Na+ binding site [ion binding]; other site 652616000987 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 652616000988 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 652616000989 Predicted glycosyl hydrolase [Carbohydrate transport and metabolism]; Region: COG4833 652616000990 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 652616000991 AAA domain; Region: AAA_33; pfam13671 652616000992 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 652616000993 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 652616000994 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 652616000995 putative hydrophobic ligand binding site [chemical binding]; other site 652616000996 MoxR-like ATPases [General function prediction only]; Region: COG0714 652616000997 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 652616000998 Ligand binding site; other site 652616000999 metal-binding site 652616001000 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 652616001001 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 652616001002 XdhC Rossmann domain; Region: XdhC_C; pfam13478 652616001003 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 652616001004 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 652616001005 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 652616001006 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 652616001007 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 652616001008 catalytic loop [active] 652616001009 iron binding site [ion binding]; other site 652616001010 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 652616001011 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 652616001012 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 652616001013 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 652616001014 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 652616001015 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 652616001016 XdhC Rossmann domain; Region: XdhC_C; pfam13478 652616001017 Transcriptional regulator [Transcription]; Region: LysR; COG0583 652616001018 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 652616001019 LysR substrate binding domain; Region: LysR_substrate; pfam03466 652616001020 dimerization interface [polypeptide binding]; other site 652616001021 Uncharacterized conserved protein [Function unknown]; Region: COG3360 652616001022 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 652616001023 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 652616001024 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 652616001025 active site 652616001026 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 652616001027 Clp amino terminal domain; Region: Clp_N; pfam02861 652616001028 Clp amino terminal domain; Region: Clp_N; pfam02861 652616001029 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 652616001030 Walker A motif; other site 652616001031 ATP binding site [chemical binding]; other site 652616001032 Walker B motif; other site 652616001033 arginine finger; other site 652616001034 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 652616001035 Walker A motif; other site 652616001036 ATP binding site [chemical binding]; other site 652616001037 Walker B motif; other site 652616001038 arginine finger; other site 652616001039 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 652616001040 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 652616001041 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 652616001042 heme-binding site [chemical binding]; other site 652616001043 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 652616001044 FAD binding pocket [chemical binding]; other site 652616001045 FAD binding motif [chemical binding]; other site 652616001046 phosphate binding motif [ion binding]; other site 652616001047 beta-alpha-beta structure motif; other site 652616001048 NAD binding pocket [chemical binding]; other site 652616001049 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 652616001050 cyclase homology domain; Region: CHD; cd07302 652616001051 nucleotidyl binding site; other site 652616001052 metal binding site [ion binding]; metal-binding site 652616001053 dimer interface [polypeptide binding]; other site 652616001054 Predicted ATPase [General function prediction only]; Region: COG3903 652616001055 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 652616001056 Walker A motif; other site 652616001057 ATP binding site [chemical binding]; other site 652616001058 Walker B motif; other site 652616001059 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 652616001060 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 652616001061 DNA binding residues [nucleotide binding] 652616001062 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616001063 PPE family; Region: PPE; pfam00823 652616001064 phosphoribosylglycinamide formyltransferase 2; Region: purT; TIGR01142 652616001065 ATP-grasp domain; Region: ATP-grasp_4; cl17255 652616001066 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 652616001067 active site residue [active] 652616001068 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 652616001069 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 652616001070 homodimer interface [polypeptide binding]; other site 652616001071 substrate-cofactor binding pocket; other site 652616001072 pyridoxal 5'-phosphate binding site [chemical binding]; other site 652616001073 catalytic residue [active] 652616001074 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 652616001075 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 652616001076 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 652616001077 Domain of unknown function (DUF222); Region: DUF222; pfam02720 652616001078 Domain of unknown function (DUF222); Region: DUF222; pfam02720 652616001079 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 652616001080 active site 652616001081 PLD-like domain; Region: PLDc_2; pfam13091 652616001082 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 652616001083 Beta-lactamase; Region: Beta-lactamase; pfam00144 652616001084 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 652616001085 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 652616001086 FAD binding site [chemical binding]; other site 652616001087 substrate binding pocket [chemical binding]; other site 652616001088 catalytic base [active] 652616001089 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 652616001090 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 652616001091 putative transposase OrfB; Reviewed; Region: PHA02517 652616001092 HTH-like domain; Region: HTH_21; pfam13276 652616001093 Integrase core domain; Region: rve; pfam00665 652616001094 Integrase core domain; Region: rve_3; pfam13683 652616001095 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 652616001096 acyl-CoA synthetase; Validated; Region: PRK05850 652616001097 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 652616001098 acyl-activating enzyme (AAE) consensus motif; other site 652616001099 active site 652616001100 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 652616001101 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 652616001102 active site 652616001103 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 652616001104 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 652616001105 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 652616001106 Thioesterase; Region: PKS_TE; smart00824 652616001107 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 652616001108 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 652616001109 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 652616001110 phosphate acetyltransferase; Reviewed; Region: PRK05632 652616001111 DRTGG domain; Region: DRTGG; pfam07085 652616001112 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 652616001113 propionate/acetate kinase; Provisional; Region: PRK12379 652616001114 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 652616001115 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 652616001116 Catalytic domain of Protein Kinases; Region: PKc; cd00180 652616001117 active site 652616001118 ATP binding site [chemical binding]; other site 652616001119 substrate binding site [chemical binding]; other site 652616001120 activation loop (A-loop); other site 652616001121 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 652616001122 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 652616001123 substrate binding pocket [chemical binding]; other site 652616001124 membrane-bound complex binding site; other site 652616001125 hinge residues; other site 652616001126 NUDIX domain; Region: NUDIX; pfam00293 652616001127 nudix motif; other site 652616001128 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 652616001129 thiamine phosphate binding site [chemical binding]; other site 652616001130 active site 652616001131 pyrophosphate binding site [ion binding]; other site 652616001132 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 652616001133 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 652616001134 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 652616001135 thiS-thiF/thiG interaction site; other site 652616001136 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 652616001137 ThiS interaction site; other site 652616001138 putative active site [active] 652616001139 tetramer interface [polypeptide binding]; other site 652616001140 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 652616001141 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 652616001142 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 652616001143 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 652616001144 PA/protease or protease-like domain interface [polypeptide binding]; other site 652616001145 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 652616001146 active site 652616001147 metal binding site [ion binding]; metal-binding site 652616001148 Predicted metalloprotease [General function prediction only]; Region: COG2321 652616001149 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 652616001150 Zn binding site [ion binding]; other site 652616001151 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 652616001152 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 652616001153 dimer interface [polypeptide binding]; other site 652616001154 substrate binding site [chemical binding]; other site 652616001155 ATP binding site [chemical binding]; other site 652616001156 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 652616001157 ThiC-associated domain; Region: ThiC-associated; pfam13667 652616001158 ThiC family; Region: ThiC; pfam01964 652616001159 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 652616001160 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 652616001161 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 652616001162 motif II; other site 652616001163 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 652616001164 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 652616001165 putative catalytic site [active] 652616001166 putative phosphate binding site [ion binding]; other site 652616001167 active site 652616001168 metal binding site A [ion binding]; metal-binding site 652616001169 DNA binding site [nucleotide binding] 652616001170 putative AP binding site [nucleotide binding]; other site 652616001171 putative metal binding site B [ion binding]; other site 652616001172 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 652616001173 active site 652616001174 catalytic residues [active] 652616001175 metal binding site [ion binding]; metal-binding site 652616001176 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 652616001177 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 652616001178 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 652616001179 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 652616001180 E-class dimer interface [polypeptide binding]; other site 652616001181 P-class dimer interface [polypeptide binding]; other site 652616001182 active site 652616001183 Cu2+ binding site [ion binding]; other site 652616001184 Zn2+ binding site [ion binding]; other site 652616001185 carboxylate-amine ligase; Provisional; Region: PRK13517 652616001186 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 652616001187 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 652616001188 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 652616001189 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 652616001190 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 652616001191 Walker A motif; other site 652616001192 ATP binding site [chemical binding]; other site 652616001193 Walker B motif; other site 652616001194 arginine finger; other site 652616001195 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 652616001196 Walker A motif; other site 652616001197 ATP binding site [chemical binding]; other site 652616001198 Walker B motif; other site 652616001199 arginine finger; other site 652616001200 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 652616001201 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 652616001202 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 652616001203 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 652616001204 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 652616001205 dimer interface [polypeptide binding]; other site 652616001206 putative functional site; other site 652616001207 putative MPT binding site; other site 652616001208 short chain dehydrogenase; Provisional; Region: PRK06197 652616001209 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 652616001210 putative NAD(P) binding site [chemical binding]; other site 652616001211 active site 652616001212 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 652616001213 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 652616001214 ring oligomerisation interface [polypeptide binding]; other site 652616001215 ATP/Mg binding site [chemical binding]; other site 652616001216 stacking interactions; other site 652616001217 hinge regions; other site 652616001218 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616001219 PPE family; Region: PPE; pfam00823 652616001220 Protein of unknown function (DUF664); Region: DUF664; pfam04978 652616001221 DinB superfamily; Region: DinB_2; pfam12867 652616001222 putative anti-sigmaE protein; Provisional; Region: PRK13920 652616001223 Anti-sigma-K factor rskA; Region: RskA; pfam10099 652616001224 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 652616001225 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 652616001226 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 652616001227 DNA binding residues [nucleotide binding] 652616001228 Steroid 5-alpha reductase family enzyme [General function prediction only]; Region: COG3752 652616001229 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 652616001230 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 652616001231 S-adenosylmethionine binding site [chemical binding]; other site 652616001232 Uncharacterized conserved protein [Function unknown]; Region: COG3496 652616001233 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 652616001234 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 652616001235 Subunit A of Class III extradiol dioxygenases; Region: Extradiol_Dioxygenase_3A_like; cl06673 652616001236 dimer interface [polypeptide binding]; other site 652616001237 Transport protein; Region: actII; TIGR00833 652616001238 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 652616001239 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 652616001240 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616001241 PPE family; Region: PPE; pfam00823 652616001242 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616001243 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 652616001244 enoyl-CoA hydratase; Provisional; Region: PRK12478 652616001245 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 652616001246 substrate binding site [chemical binding]; other site 652616001247 oxyanion hole (OAH) forming residues; other site 652616001248 trimer interface [polypeptide binding]; other site 652616001249 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 652616001250 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 652616001251 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 652616001252 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 652616001253 NAD(P) binding site [chemical binding]; other site 652616001254 catalytic residues [active] 652616001255 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3564 652616001256 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 652616001257 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 652616001258 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 652616001259 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 652616001260 Uncharacterized conserved protein [Function unknown]; Region: COG2128 652616001261 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 652616001262 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 652616001263 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 652616001264 non-specific DNA binding site [nucleotide binding]; other site 652616001265 salt bridge; other site 652616001266 sequence-specific DNA binding site [nucleotide binding]; other site 652616001267 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 652616001268 Domain of unknown function (DUF955); Region: DUF955; pfam06114 652616001269 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 652616001270 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 652616001271 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 652616001272 active site 652616001273 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 652616001274 active site 2 [active] 652616001275 isocitrate lyase; Provisional; Region: PRK15063 652616001276 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cd06556 652616001277 oligomerization interface [polypeptide binding]; other site 652616001278 active site 652616001279 metal binding site [ion binding]; metal-binding site 652616001280 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 652616001281 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 652616001282 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 652616001283 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 652616001284 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 652616001285 S-adenosylmethionine binding site [chemical binding]; other site 652616001286 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 652616001287 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 652616001288 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 652616001289 S-adenosylmethionine binding site [chemical binding]; other site 652616001290 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 652616001291 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 652616001292 Predicted membrane protein [Function unknown]; Region: COG2733 652616001293 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 652616001294 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 652616001295 non-specific DNA binding site [nucleotide binding]; other site 652616001296 salt bridge; other site 652616001297 sequence-specific DNA binding site [nucleotide binding]; other site 652616001298 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 652616001299 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 652616001300 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 652616001301 intersubunit interface [polypeptide binding]; other site 652616001302 active site 652616001303 catalytic residue [active] 652616001304 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 652616001305 Predicted amidohydrolase [General function prediction only]; Region: COG0388 652616001306 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 652616001307 putative active site [active] 652616001308 catalytic triad [active] 652616001309 putative dimer interface [polypeptide binding]; other site 652616001310 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 652616001311 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 652616001312 FAD binding domain; Region: FAD_binding_4; pfam01565 652616001313 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 652616001314 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 652616001315 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 652616001316 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 652616001317 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 652616001318 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 652616001319 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 652616001320 NAD(P) binding site [chemical binding]; other site 652616001321 active site 652616001322 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 652616001323 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 652616001324 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 652616001325 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 652616001326 putative ADP-binding pocket [chemical binding]; other site 652616001327 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 652616001328 L-lysine exporter; Region: 2a75; TIGR00948 652616001329 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 652616001330 catalytic core [active] 652616001331 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 652616001332 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 652616001333 dimer interface [polypeptide binding]; other site 652616001334 phosphorylation site [posttranslational modification] 652616001335 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 652616001336 ATP binding site [chemical binding]; other site 652616001337 Mg2+ binding site [ion binding]; other site 652616001338 G-X-G motif; other site 652616001339 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 652616001340 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 652616001341 active site 652616001342 phosphorylation site [posttranslational modification] 652616001343 intermolecular recognition site; other site 652616001344 dimerization interface [polypeptide binding]; other site 652616001345 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 652616001346 DNA binding site [nucleotide binding] 652616001347 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 652616001348 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 652616001349 Transcriptional regulators [Transcription]; Region: FadR; COG2186 652616001350 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 652616001351 DNA-binding site [nucleotide binding]; DNA binding site 652616001352 FCD domain; Region: FCD; pfam07729 652616001353 exopolyphosphatase; Region: exo_poly_only; TIGR03706 652616001354 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 652616001355 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 652616001356 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 652616001357 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 652616001358 Diacylglycerol kinase catalytic domain (presumed); Region: DAGKc; smart00046 652616001359 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 652616001360 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 652616001361 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 652616001362 DNA binding domain, excisionase family; Region: excise; TIGR01764 652616001363 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 652616001364 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 652616001365 putative NAD(P) binding site [chemical binding]; other site 652616001366 active site 652616001367 putative substrate binding site [chemical binding]; other site 652616001368 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 652616001369 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 652616001370 putative acyl-acceptor binding pocket; other site 652616001371 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 652616001372 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 652616001373 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 652616001374 S-adenosylmethionine binding site [chemical binding]; other site 652616001375 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 652616001376 active site 652616001377 catalytic site [active] 652616001378 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 652616001379 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 652616001380 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 652616001381 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 652616001382 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 652616001383 glutamyl-tRNA reductase; Region: hemA; TIGR01035 652616001384 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 652616001385 tRNA; other site 652616001386 putative tRNA binding site [nucleotide binding]; other site 652616001387 putative NADP binding site [chemical binding]; other site 652616001388 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 652616001389 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 652616001390 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 652616001391 active site 652616001392 domain interfaces; other site 652616001393 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 652616001394 active site 652616001395 homodimer interface [polypeptide binding]; other site 652616001396 SAM binding site [chemical binding]; other site 652616001397 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 652616001398 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 652616001399 active site 652616001400 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 652616001401 dimer interface [polypeptide binding]; other site 652616001402 active site 652616001403 Schiff base residues; other site 652616001404 Domain of unknown function (DUF222); Region: DUF222; pfam02720 652616001405 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 652616001406 active site 652616001407 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 652616001408 anti sigma factor interaction site; other site 652616001409 regulatory phosphorylation site [posttranslational modification]; other site 652616001410 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 652616001411 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 652616001412 active site 652616001413 catalytic triad [active] 652616001414 oxyanion hole [active] 652616001415 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 652616001416 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 652616001417 Methyltransferase domain; Region: Methyltransf_31; pfam13847 652616001418 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 652616001419 Domain of unknown function (DUF385); Region: DUF385; pfam04075 652616001420 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 652616001421 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 652616001422 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 652616001423 catalytic residue [active] 652616001424 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 652616001425 catalytic core [active] 652616001426 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 652616001427 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 652616001428 catalytic residues [active] 652616001429 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 652616001430 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 652616001431 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 652616001432 ResB-like family; Region: ResB; pfam05140 652616001433 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 652616001434 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 652616001435 AAA domain; Region: AAA_31; pfam13614 652616001436 P-loop; other site 652616001437 Magnesium ion binding site [ion binding]; other site 652616001438 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 652616001439 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 652616001440 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 652616001441 UbiA prenyltransferase family; Region: UbiA; pfam01040 652616001442 5'-methylthioadenosine phosphorylase; Validated; Region: PRK07823 652616001443 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 652616001444 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 652616001445 NAD(P) binding site [chemical binding]; other site 652616001446 active site 652616001447 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 652616001448 Ligand binding site; other site 652616001449 Putative Catalytic site; other site 652616001450 DXD motif; other site 652616001451 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3222 652616001452 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 652616001453 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 652616001454 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 652616001455 acyl-activating enzyme (AAE) consensus motif; other site 652616001456 acyl-activating enzyme (AAE) consensus motif; other site 652616001457 AMP binding site [chemical binding]; other site 652616001458 active site 652616001459 CoA binding site [chemical binding]; other site 652616001460 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 652616001461 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 652616001462 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 652616001463 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 652616001464 active site 652616001465 short chain dehydrogenase; Provisional; Region: PRK05866 652616001466 classical (c) SDRs; Region: SDR_c; cd05233 652616001467 NAD(P) binding site [chemical binding]; other site 652616001468 active site 652616001469 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 652616001470 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 652616001471 substrate binding site [chemical binding]; other site 652616001472 oxyanion hole (OAH) forming residues; other site 652616001473 trimer interface [polypeptide binding]; other site 652616001474 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 652616001475 putative active site [active] 652616001476 homotetrameric interface [polypeptide binding]; other site 652616001477 metal binding site [ion binding]; metal-binding site 652616001478 Post-segregation antitoxin (ccd killing mechanism protein) encoded by the F plasmid [General function prediction only]; Region: COG5302 652616001479 acyl-CoA synthetase; Validated; Region: PRK06188 652616001480 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 652616001481 putative active site [active] 652616001482 putative CoA binding site [chemical binding]; other site 652616001483 putative AMP binding site [chemical binding]; other site 652616001484 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 652616001485 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 652616001486 active site 652616001487 O-succinylbenzoate synthase; Provisional; Region: PRK02901 652616001488 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 652616001489 active site 652616001490 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 652616001491 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 652616001492 TAP-like protein; Region: Abhydrolase_4; pfam08386 652616001493 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 652616001494 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 652616001495 dimer interface [polypeptide binding]; other site 652616001496 tetramer interface [polypeptide binding]; other site 652616001497 PYR/PP interface [polypeptide binding]; other site 652616001498 TPP binding site [chemical binding]; other site 652616001499 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 652616001500 TPP-binding site; other site 652616001501 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 652616001502 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 652616001503 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 652616001504 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 652616001505 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 652616001506 S-adenosylmethionine binding site [chemical binding]; other site 652616001507 Protein of unknown function (DUF732); Region: DUF732; pfam05305 652616001508 Methyltransferase domain; Region: Methyltransf_23; pfam13489 652616001509 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 652616001510 S-adenosylmethionine binding site [chemical binding]; other site 652616001511 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 652616001512 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 652616001513 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 652616001514 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 652616001515 substrate binding pocket [chemical binding]; other site 652616001516 chain length determination region; other site 652616001517 substrate-Mg2+ binding site; other site 652616001518 catalytic residues [active] 652616001519 aspartate-rich region 1; other site 652616001520 active site lid residues [active] 652616001521 aspartate-rich region 2; other site 652616001522 heat shock protein HtpX; Provisional; Region: PRK03072 652616001523 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439 652616001524 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 652616001525 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 652616001526 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 652616001527 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 652616001528 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 652616001529 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 652616001530 O-methyltransferase; Region: Methyltransf_2; pfam00891 652616001531 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 652616001532 Cytochrome P450; Region: p450; cl12078 652616001533 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 652616001534 ATP cone domain; Region: ATP-cone; pfam03477 652616001535 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 652616001536 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 652616001537 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 652616001538 active site 652616001539 dimer interface [polypeptide binding]; other site 652616001540 effector binding site; other site 652616001541 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 652616001542 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 652616001543 active site 652616001544 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 652616001545 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 652616001546 nicotinate phosphoribosyltransferase; Provisional; Region: PRK12484 652616001547 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 652616001548 active site 652616001549 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 652616001550 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 652616001551 putative active site [active] 652616001552 putative metal binding site [ion binding]; other site 652616001553 hypothetical protein; Provisional; Region: PRK07588 652616001554 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 652616001555 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 652616001556 dimerization interface [polypeptide binding]; other site 652616001557 putative DNA binding site [nucleotide binding]; other site 652616001558 putative Zn2+ binding site [ion binding]; other site 652616001559 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 652616001560 putative hydrophobic ligand binding site [chemical binding]; other site 652616001561 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 652616001562 TIGR03086 family protein; Region: TIGR03086 652616001563 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 652616001564 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 652616001565 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 652616001566 PE family; Region: PE; pfam00934 652616001567 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451 652616001568 Uncharacterized conserved protein [Function unknown]; Region: COG1656 652616001569 Protein of unknown function DUF82; Region: DUF82; pfam01927 652616001570 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 652616001571 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 652616001572 putative active site [active] 652616001573 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 652616001574 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 652616001575 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 652616001576 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 652616001577 Transcriptional regulators [Transcription]; Region: FadR; COG2186 652616001578 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 652616001579 DNA-binding site [nucleotide binding]; DNA binding site 652616001580 FCD domain; Region: FCD; pfam07729 652616001581 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 652616001582 Permease; Region: Permease; pfam02405 652616001583 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 652616001584 Permease; Region: Permease; pfam02405 652616001585 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 652616001586 mce related protein; Region: MCE; pfam02470 652616001587 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 652616001588 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 652616001589 mce related protein; Region: MCE; pfam02470 652616001590 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 652616001591 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 652616001592 mce related protein; Region: MCE; pfam02470 652616001593 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 652616001594 mce related protein; Region: MCE; pfam02470 652616001595 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 652616001596 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 652616001597 mce related protein; Region: MCE; pfam02470 652616001598 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 652616001599 mce related protein; Region: MCE; pfam02470 652616001600 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 652616001601 oligomeric interface; other site 652616001602 putative active site [active] 652616001603 homodimer interface [polypeptide binding]; other site 652616001604 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 652616001605 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 652616001606 AAA domain; Region: AAA_14; pfam13173 652616001607 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 652616001608 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 652616001609 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 652616001610 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 652616001611 ATP binding site [chemical binding]; other site 652616001612 Mg2+ binding site [ion binding]; other site 652616001613 G-X-G motif; other site 652616001614 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 652616001615 dimerization interface [polypeptide binding]; other site 652616001616 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 652616001617 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 652616001618 active site 652616001619 phosphorylation site [posttranslational modification] 652616001620 intermolecular recognition site; other site 652616001621 dimerization interface [polypeptide binding]; other site 652616001622 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 652616001623 DNA binding site [nucleotide binding] 652616001624 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 652616001625 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 652616001626 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 652616001627 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 652616001628 catalytic residues [active] 652616001629 catalytic nucleophile [active] 652616001630 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 652616001631 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 652616001632 Probable transposase; Region: OrfB_IS605; pfam01385 652616001633 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 652616001634 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 652616001635 putative active site [active] 652616001636 SEC-C motif; Region: SEC-C; pfam02810 652616001637 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB-like; cd09875 652616001638 putative active site [active] 652616001639 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 652616001640 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 652616001641 nucleotide binding site/active site [active] 652616001642 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 652616001643 galactokinase; Provisional; Region: PRK00555 652616001644 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 652616001645 Protein of unknown function (DUF732); Region: DUF732; pfam05305 652616001646 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 652616001647 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 652616001648 putative active site [active] 652616001649 Uncharacterized conserved protein [Function unknown]; Region: COG0398 652616001650 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 652616001651 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 652616001652 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 652616001653 oligomeric interface; other site 652616001654 putative active site [active] 652616001655 homodimer interface [polypeptide binding]; other site 652616001656 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 652616001657 FIST N domain; Region: FIST; pfam08495 652616001658 FIST C domain; Region: FIST_C; pfam10442 652616001659 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 652616001660 AAA domain; Region: AAA_30; pfam13604 652616001661 Family description; Region: UvrD_C_2; pfam13538 652616001662 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 652616001663 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 652616001664 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 652616001665 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 652616001666 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 652616001667 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 652616001668 substrate binding site [chemical binding]; other site 652616001669 oxyanion hole (OAH) forming residues; other site 652616001670 trimer interface [polypeptide binding]; other site 652616001671 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 652616001672 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 652616001673 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 652616001674 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 652616001675 active site 652616001676 catalytic site [active] 652616001677 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 652616001678 active site 652616001679 catalytic site [active] 652616001680 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 652616001681 active site 652616001682 catalytic site [active] 652616001683 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 652616001684 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 652616001685 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 652616001686 putative homodimer interface [polypeptide binding]; other site 652616001687 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 652616001688 heterodimer interface [polypeptide binding]; other site 652616001689 homodimer interface [polypeptide binding]; other site 652616001690 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 652616001691 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 652616001692 23S rRNA interface [nucleotide binding]; other site 652616001693 L7/L12 interface [polypeptide binding]; other site 652616001694 putative thiostrepton binding site; other site 652616001695 L25 interface [polypeptide binding]; other site 652616001696 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 652616001697 mRNA/rRNA interface [nucleotide binding]; other site 652616001698 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 652616001699 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 652616001700 S-adenosylmethionine binding site [chemical binding]; other site 652616001701 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 652616001702 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 652616001703 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 652616001704 S-adenosylmethionine binding site [chemical binding]; other site 652616001705 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 652616001706 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 652616001707 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 652616001708 S-adenosylmethionine binding site [chemical binding]; other site 652616001709 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 652616001710 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 652616001711 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 652616001712 S-adenosylmethionine binding site [chemical binding]; other site 652616001713 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 652616001714 TAP-like protein; Region: Abhydrolase_4; pfam08386 652616001715 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 652616001716 ABC1 family; Region: ABC1; cl17513 652616001717 N-terminal catalytic domain of class II alpha-mannosidases and similar proteins; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_like; cd10786 652616001718 active site 652616001719 catalytic site [active] 652616001720 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 652616001721 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 652616001722 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 652616001723 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 652616001724 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 652616001725 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 652616001726 23S rRNA interface [nucleotide binding]; other site 652616001727 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 652616001728 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 652616001729 core dimer interface [polypeptide binding]; other site 652616001730 peripheral dimer interface [polypeptide binding]; other site 652616001731 L10 interface [polypeptide binding]; other site 652616001732 L11 interface [polypeptide binding]; other site 652616001733 putative EF-Tu interaction site [polypeptide binding]; other site 652616001734 putative EF-G interaction site [polypeptide binding]; other site 652616001735 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 652616001736 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 652616001737 WHG domain; Region: WHG; pfam13305 652616001738 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 652616001739 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 652616001740 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 652616001741 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 652616001742 Walker A/P-loop; other site 652616001743 ATP binding site [chemical binding]; other site 652616001744 Q-loop/lid; other site 652616001745 ABC transporter signature motif; other site 652616001746 Walker B; other site 652616001747 D-loop; other site 652616001748 H-loop/switch region; other site 652616001749 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 652616001750 putative active site [active] 652616001751 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 652616001752 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 652616001753 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 652616001754 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG1848 652616001755 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 652616001756 Sulfatase; Region: Sulfatase; pfam00884 652616001757 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 652616001758 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 652616001759 putative active site [active] 652616001760 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 652616001761 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 652616001762 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 652616001763 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 652616001764 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 652616001765 RPB10 interaction site [polypeptide binding]; other site 652616001766 RPB1 interaction site [polypeptide binding]; other site 652616001767 RPB11 interaction site [polypeptide binding]; other site 652616001768 RPB3 interaction site [polypeptide binding]; other site 652616001769 RPB12 interaction site [polypeptide binding]; other site 652616001770 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 652616001771 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 652616001772 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 652616001773 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 652616001774 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 652616001775 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 652616001776 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 652616001777 G-loop; other site 652616001778 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 652616001779 DNA binding site [nucleotide binding] 652616001780 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 652616001781 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; pfam04734 652616001782 endonuclease IV; Provisional; Region: PRK01060 652616001783 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 652616001784 AP (apurinic/apyrimidinic) site pocket; other site 652616001785 DNA interaction; other site 652616001786 Metal-binding active site; metal-binding site 652616001787 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 652616001788 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 652616001789 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 652616001790 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 652616001791 active site 652616001792 enoyl-CoA hydratase; Provisional; Region: PRK12478 652616001793 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 652616001794 substrate binding site [chemical binding]; other site 652616001795 oxyanion hole (OAH) forming residues; other site 652616001796 trimer interface [polypeptide binding]; other site 652616001797 PaaX-like protein; Region: PaaX; pfam07848 652616001798 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 652616001799 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 652616001800 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 652616001801 substrate binding site [chemical binding]; other site 652616001802 oxyanion hole (OAH) forming residues; other site 652616001803 trimer interface [polypeptide binding]; other site 652616001804 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 652616001805 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 652616001806 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 652616001807 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 652616001808 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 652616001809 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 652616001810 WHG domain; Region: WHG; pfam13305 652616001811 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 652616001812 S17 interaction site [polypeptide binding]; other site 652616001813 S8 interaction site; other site 652616001814 16S rRNA interaction site [nucleotide binding]; other site 652616001815 streptomycin interaction site [chemical binding]; other site 652616001816 23S rRNA interaction site [nucleotide binding]; other site 652616001817 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 652616001818 30S ribosomal protein S7; Validated; Region: PRK05302 652616001819 elongation factor G; Reviewed; Region: PRK00007 652616001820 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 652616001821 G1 box; other site 652616001822 putative GEF interaction site [polypeptide binding]; other site 652616001823 GTP/Mg2+ binding site [chemical binding]; other site 652616001824 Switch I region; other site 652616001825 G2 box; other site 652616001826 G3 box; other site 652616001827 Switch II region; other site 652616001828 G4 box; other site 652616001829 G5 box; other site 652616001830 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 652616001831 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 652616001832 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 652616001833 elongation factor Tu; Reviewed; Region: PRK00049 652616001834 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 652616001835 G1 box; other site 652616001836 GEF interaction site [polypeptide binding]; other site 652616001837 GTP/Mg2+ binding site [chemical binding]; other site 652616001838 Switch I region; other site 652616001839 G2 box; other site 652616001840 G3 box; other site 652616001841 Switch II region; other site 652616001842 G4 box; other site 652616001843 G5 box; other site 652616001844 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 652616001845 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 652616001846 Antibiotic Binding Site [chemical binding]; other site 652616001847 Short C-terminal domain; Region: SHOCT; pfam09851 652616001848 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 652616001849 classical (c) SDRs; Region: SDR_c; cd05233 652616001850 NAD(P) binding site [chemical binding]; other site 652616001851 active site 652616001852 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 652616001853 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 652616001854 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4427 652616001855 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 652616001856 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 652616001857 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 652616001858 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 652616001859 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 652616001860 FeS/SAM binding site; other site 652616001861 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 652616001862 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 652616001863 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 652616001864 phosphate binding site [ion binding]; other site 652616001865 mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964 652616001866 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 652616001867 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 652616001868 Probable Catalytic site; other site 652616001869 metal-binding site 652616001870 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 652616001871 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 652616001872 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 652616001873 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 652616001874 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 652616001875 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 652616001876 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 652616001877 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 652616001878 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 652616001879 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 652616001880 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 652616001881 putative translocon binding site; other site 652616001882 protein-rRNA interface [nucleotide binding]; other site 652616001883 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 652616001884 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 652616001885 G-X-X-G motif; other site 652616001886 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 652616001887 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 652616001888 23S rRNA interface [nucleotide binding]; other site 652616001889 5S rRNA interface [nucleotide binding]; other site 652616001890 putative antibiotic binding site [chemical binding]; other site 652616001891 L25 interface [polypeptide binding]; other site 652616001892 L27 interface [polypeptide binding]; other site 652616001893 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 652616001894 putative translocon interaction site; other site 652616001895 23S rRNA interface [nucleotide binding]; other site 652616001896 signal recognition particle (SRP54) interaction site; other site 652616001897 L23 interface [polypeptide binding]; other site 652616001898 trigger factor interaction site; other site 652616001899 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 652616001900 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 652616001901 Sulfatase; Region: Sulfatase; pfam00884 652616001902 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353 652616001903 Uncharacterized conserved protein [Function unknown]; Region: COG1262 652616001904 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 652616001905 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 652616001906 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 652616001907 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 652616001908 RNA binding site [nucleotide binding]; other site 652616001909 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 652616001910 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 652616001911 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 652616001912 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 652616001913 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 652616001914 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 652616001915 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 652616001916 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 652616001917 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 652616001918 5S rRNA interface [nucleotide binding]; other site 652616001919 23S rRNA interface [nucleotide binding]; other site 652616001920 L5 interface [polypeptide binding]; other site 652616001921 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 652616001922 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 652616001923 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 652616001924 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 652616001925 23S rRNA binding site [nucleotide binding]; other site 652616001926 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 652616001927 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 652616001928 tandem repeat interface [polypeptide binding]; other site 652616001929 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 652616001930 oligomer interface [polypeptide binding]; other site 652616001931 active site residues [active] 652616001932 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 652616001933 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 652616001934 tandem repeat interface [polypeptide binding]; other site 652616001935 oligomer interface [polypeptide binding]; other site 652616001936 active site residues [active] 652616001937 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 652616001938 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 652616001939 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 652616001940 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 652616001941 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 652616001942 intersubunit interface [polypeptide binding]; other site 652616001943 active site 652616001944 Zn2+ binding site [ion binding]; other site 652616001945 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 652616001946 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 652616001947 NAD binding site [chemical binding]; other site 652616001948 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 652616001949 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 652616001950 nucleotide binding site [chemical binding]; other site 652616001951 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 652616001952 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 652616001953 Coenzyme A binding pocket [chemical binding]; other site 652616001954 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 652616001955 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 652616001956 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 652616001957 SecY translocase; Region: SecY; pfam00344 652616001958 adenylate kinase; Reviewed; Region: adk; PRK00279 652616001959 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 652616001960 AMP-binding site [chemical binding]; other site 652616001961 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 652616001962 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 652616001963 active site 652616001964 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 652616001965 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 652616001966 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 652616001967 DNA binding residues [nucleotide binding] 652616001968 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 652616001969 Putative zinc-finger; Region: zf-HC2; pfam13490 652616001970 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 652616001971 PYR/PP interface [polypeptide binding]; other site 652616001972 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 652616001973 MarR family; Region: MarR; pfam01047 652616001974 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 652616001975 TIGR03086 family protein; Region: TIGR03086 652616001976 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 652616001977 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 652616001978 Transposase; Region: DDE_Tnp_ISL3; pfam01610 652616001979 Helix-turn-helix domain; Region: HTH_17; pfam12728 652616001980 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 652616001981 PE family; Region: PE; pfam00934 652616001982 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 652616001983 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 652616001984 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 652616001985 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 652616001986 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 652616001987 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 652616001988 active site 652616001989 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 652616001990 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 652616001991 tetrameric interface [polypeptide binding]; other site 652616001992 NAD binding site [chemical binding]; other site 652616001993 catalytic residues [active] 652616001994 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 652616001995 catalytic core [active] 652616001996 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616001997 PPE family; Region: PPE; pfam00823 652616001998 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 652616001999 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 652616002000 Helix-turn-helix domain; Region: HTH_28; pfam13518 652616002001 Winged helix-turn helix; Region: HTH_29; pfam13551 652616002002 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 652616002003 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 652616002004 active site 652616002005 phosphorylation site [posttranslational modification] 652616002006 intermolecular recognition site; other site 652616002007 dimerization interface [polypeptide binding]; other site 652616002008 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 652616002009 DNA binding site [nucleotide binding] 652616002010 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 652616002011 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 652616002012 dimerization interface [polypeptide binding]; other site 652616002013 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 652616002014 dimer interface [polypeptide binding]; other site 652616002015 phosphorylation site [posttranslational modification] 652616002016 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 652616002017 ATP binding site [chemical binding]; other site 652616002018 Mg2+ binding site [ion binding]; other site 652616002019 G-X-G motif; other site 652616002020 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 652616002021 nucleotide binding site/active site [active] 652616002022 HIT family signature motif; other site 652616002023 catalytic residue [active] 652616002024 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 652616002025 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 652616002026 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 652616002027 NAD binding site [chemical binding]; other site 652616002028 catalytic Zn binding site [ion binding]; other site 652616002029 substrate binding site [chemical binding]; other site 652616002030 structural Zn binding site [ion binding]; other site 652616002031 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 652616002032 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 652616002033 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 652616002034 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 652616002035 Cytochrome P450; Region: p450; cl12078 652616002036 short chain dehydrogenase; Provisional; Region: PRK07775 652616002037 classical (c) SDRs; Region: SDR_c; cd05233 652616002038 NAD(P) binding site [chemical binding]; other site 652616002039 active site 652616002040 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 652616002041 Cytochrome P450; Region: p450; cl12078 652616002042 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 652616002043 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 652616002044 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 652616002045 NAD binding site [chemical binding]; other site 652616002046 catalytic residues [active] 652616002047 short chain dehydrogenase; Provisional; Region: PRK07774 652616002048 classical (c) SDRs; Region: SDR_c; cd05233 652616002049 NAD(P) binding site [chemical binding]; other site 652616002050 active site 652616002051 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 652616002052 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 652616002053 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 652616002054 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 652616002055 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 652616002056 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 652616002057 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 652616002058 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 652616002059 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 652616002060 Predicted esterase [General function prediction only]; Region: COG0627 652616002061 S-formylglutathione hydrolase; Region: PLN02442 652616002062 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 652616002063 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 652616002064 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 652616002065 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 652616002066 tetramer interface [polypeptide binding]; other site 652616002067 active site 652616002068 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 652616002069 Cytochrome P450; Region: p450; cl12078 652616002070 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 652616002071 ATP binding site [chemical binding]; other site 652616002072 active site 652616002073 substrate binding site [chemical binding]; other site 652616002074 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 652616002075 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 652616002076 WHG domain; Region: WHG; pfam13305 652616002077 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 652616002078 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 652616002079 putative substrate translocation pore; other site 652616002080 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 652616002081 Predicted deacetylase [General function prediction only]; Region: COG3233 652616002082 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 652616002083 putative active site [active] 652616002084 putative Zn binding site [ion binding]; other site 652616002085 FAD binding domain; Region: FAD_binding_2; pfam00890 652616002086 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 652616002087 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 652616002088 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 652616002089 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 652616002090 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 652616002091 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 652616002092 putative active site [active] 652616002093 catalytic triad [active] 652616002094 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 652616002095 Transglutaminase/protease-like homologues; Region: TGc; smart00460 652616002096 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 652616002097 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 652616002098 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 652616002099 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 652616002100 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 652616002101 DNA-binding site [nucleotide binding]; DNA binding site 652616002102 UTRA domain; Region: UTRA; pfam07702 652616002103 Uncharacterized conserved protein [Function unknown]; Region: COG1359 652616002104 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 652616002105 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 652616002106 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 652616002107 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 652616002108 putative transposase OrfB; Reviewed; Region: PHA02517 652616002109 HTH-like domain; Region: HTH_21; pfam13276 652616002110 Integrase core domain; Region: rve; pfam00665 652616002111 Integrase core domain; Region: rve_3; pfam13683 652616002112 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 652616002113 Transposase; Region: HTH_Tnp_1; cl17663 652616002114 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 652616002115 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 652616002116 Uncharacterized protein, linocin/CFP29 homolog [Function unknown]; Region: COG1659 652616002117 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 652616002118 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 652616002119 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 652616002120 active site 652616002121 metal binding site [ion binding]; metal-binding site 652616002122 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 652616002123 active site 652616002124 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 652616002125 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 652616002126 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 652616002127 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 652616002128 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 652616002129 dimerization interface [polypeptide binding]; other site 652616002130 ATP binding site [chemical binding]; other site 652616002131 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 652616002132 dimerization interface [polypeptide binding]; other site 652616002133 ATP binding site [chemical binding]; other site 652616002134 CAAX protease self-immunity; Region: Abi; pfam02517 652616002135 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 652616002136 amidophosphoribosyltransferase; Provisional; Region: PRK07847 652616002137 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 652616002138 active site 652616002139 tetramer interface [polypeptide binding]; other site 652616002140 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 652616002141 active site 652616002142 phosphoribosylaminoimidazole synthetase; Region: purM; TIGR00878 652616002143 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 652616002144 dimerization interface [polypeptide binding]; other site 652616002145 putative ATP binding site [chemical binding]; other site 652616002146 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 652616002147 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 652616002148 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 652616002149 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 652616002150 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 652616002151 pyridoxal 5'-phosphate binding site [chemical binding]; other site 652616002152 catalytic residue [active] 652616002153 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 652616002154 heme-binding site [chemical binding]; other site 652616002155 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 652616002156 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 652616002157 active site residue [active] 652616002158 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 652616002159 active site residue [active] 652616002160 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 652616002161 catalytic residues [active] 652616002162 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 652616002163 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 652616002164 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 652616002165 DNA binding site [nucleotide binding] 652616002166 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 652616002167 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 652616002168 Coenzyme A binding pocket [chemical binding]; other site 652616002169 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 652616002170 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 652616002171 Walker A/P-loop; other site 652616002172 ATP binding site [chemical binding]; other site 652616002173 Q-loop/lid; other site 652616002174 ABC transporter signature motif; other site 652616002175 Walker B; other site 652616002176 D-loop; other site 652616002177 H-loop/switch region; other site 652616002178 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 652616002179 PhoU domain; Region: PhoU; pfam01895 652616002180 PhoU domain; Region: PhoU; pfam01895 652616002181 cell envelope-related function transcriptional attenuator common domain; Region: lytR_cpsA_psr; TIGR00350 652616002182 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 652616002183 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 652616002184 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 652616002185 FMN binding site [chemical binding]; other site 652616002186 active site 652616002187 catalytic residues [active] 652616002188 substrate binding site [chemical binding]; other site 652616002189 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 652616002190 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 652616002191 homodimer interface [polypeptide binding]; other site 652616002192 putative substrate binding pocket [chemical binding]; other site 652616002193 diiron center [ion binding]; other site 652616002194 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 652616002195 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 652616002196 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 652616002197 dimerization interface [polypeptide binding]; other site 652616002198 putative DNA binding site [nucleotide binding]; other site 652616002199 putative Zn2+ binding site [ion binding]; other site 652616002200 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 652616002201 dimer interface [polypeptide binding]; other site 652616002202 catalytic motif [active] 652616002203 nucleoside/Zn binding site; other site 652616002204 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 652616002205 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 652616002206 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 652616002207 TIGR04255 family protein; Region: sporadTIGR04255 652616002208 PE family; Region: PE; pfam00934 652616002209 PE family; Region: PE; pfam00934 652616002210 PknH-like extracellular domain; Region: PknH_C; pfam14032 652616002211 Predicted nucleotidyltransferase [General function prediction only]; Region: COG4849 652616002212 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4861 652616002213 Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952 652616002214 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 652616002215 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 652616002216 S-adenosylmethionine binding site [chemical binding]; other site 652616002217 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 652616002218 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 652616002219 putative substrate translocation pore; other site 652616002220 Major Facilitator Superfamily; Region: MFS_1; pfam07690 652616002221 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 652616002222 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 652616002223 tetramer interface [polypeptide binding]; other site 652616002224 TPP-binding site [chemical binding]; other site 652616002225 heterodimer interface [polypeptide binding]; other site 652616002226 phosphorylation loop region [posttranslational modification] 652616002227 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 652616002228 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 652616002229 active site 652616002230 phosphorylation site [posttranslational modification] 652616002231 intermolecular recognition site; other site 652616002232 dimerization interface [polypeptide binding]; other site 652616002233 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 652616002234 DNA binding residues [nucleotide binding] 652616002235 dimerization interface [polypeptide binding]; other site 652616002236 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 652616002237 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 652616002238 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 652616002239 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 652616002240 Multicopper oxidase; Region: Cu-oxidase; pfam00394 652616002241 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 652616002242 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 652616002243 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 652616002244 dimer interface [polypeptide binding]; other site 652616002245 pyridoxal 5'-phosphate binding site [chemical binding]; other site 652616002246 catalytic residue [active] 652616002247 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 652616002248 multidrug resistance protein MdtH; Provisional; Region: PRK11646 652616002249 putative substrate translocation pore; other site 652616002250 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 652616002251 short chain dehydrogenase; Provisional; Region: PRK05876 652616002252 classical (c) SDRs; Region: SDR_c; cd05233 652616002253 NAD(P) binding site [chemical binding]; other site 652616002254 active site 652616002255 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 652616002256 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 652616002257 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 652616002258 dimer interface [polypeptide binding]; other site 652616002259 PYR/PP interface [polypeptide binding]; other site 652616002260 TPP binding site [chemical binding]; other site 652616002261 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 652616002262 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 652616002263 TPP-binding site [chemical binding]; other site 652616002264 dimer interface [polypeptide binding]; other site 652616002265 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 652616002266 putative hydrophobic ligand binding site [chemical binding]; other site 652616002267 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 652616002268 CoA-transferase family III; Region: CoA_transf_3; pfam02515 652616002269 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 652616002270 putative hydrophobic ligand binding site [chemical binding]; other site 652616002271 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 652616002272 putative hydrophobic ligand binding site [chemical binding]; other site 652616002273 aminotransferase; Validated; Region: PRK07777 652616002274 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 652616002275 pyridoxal 5'-phosphate binding site [chemical binding]; other site 652616002276 homodimer interface [polypeptide binding]; other site 652616002277 catalytic residue [active] 652616002278 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 652616002279 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 652616002280 dimer interface [polypeptide binding]; other site 652616002281 active site 652616002282 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 652616002283 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 652616002284 substrate binding site [chemical binding]; other site 652616002285 oxyanion hole (OAH) forming residues; other site 652616002286 trimer interface [polypeptide binding]; other site 652616002287 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 652616002288 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 652616002289 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 652616002290 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 652616002291 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 652616002292 ATP binding site [chemical binding]; other site 652616002293 putative Mg++ binding site [ion binding]; other site 652616002294 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 652616002295 nucleotide binding region [chemical binding]; other site 652616002296 ATP-binding site [chemical binding]; other site 652616002297 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 652616002298 WYL domain; Region: WYL; pfam13280 652616002299 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 652616002300 trimer interface [polypeptide binding]; other site 652616002301 dimer interface [polypeptide binding]; other site 652616002302 putative active site [active] 652616002303 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 652616002304 MPT binding site; other site 652616002305 trimer interface [polypeptide binding]; other site 652616002306 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 652616002307 MoaE homodimer interface [polypeptide binding]; other site 652616002308 MoaD interaction [polypeptide binding]; other site 652616002309 active site residues [active] 652616002310 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 652616002311 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 652616002312 MoaE interaction surface [polypeptide binding]; other site 652616002313 MoeB interaction surface [polypeptide binding]; other site 652616002314 thiocarboxylated glycine; other site 652616002315 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 652616002316 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 652616002317 FeS/SAM binding site; other site 652616002318 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 652616002319 hypothetical protein; Provisional; Region: PRK11770 652616002320 Domain of unknown function (DUF307); Region: DUF307; pfam03733 652616002321 Domain of unknown function (DUF307); Region: DUF307; pfam03733 652616002322 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 652616002323 DNA-binding site [nucleotide binding]; DNA binding site 652616002324 RNA-binding motif; other site 652616002325 PE family; Region: PE; pfam00934 652616002326 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 652616002327 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 652616002328 active site 652616002329 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 652616002330 FIST N domain; Region: FIST; pfam08495 652616002331 FIST C domain; Region: FIST_C; pfam10442 652616002332 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 652616002333 H+ Antiporter protein; Region: 2A0121; TIGR00900 652616002334 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 652616002335 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616002336 PPE family; Region: PPE; pfam00823 652616002337 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 652616002338 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 652616002339 Protein of unknown function (DUF2530); Region: DUF2530; pfam10745 652616002340 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 652616002341 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 652616002342 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 652616002343 Protein of unknown function (DUF2537); Region: DUF2537; pfam10801 652616002344 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 652616002345 phosphoserine aminotransferase, putative; Region: serC_3; TIGR01366 652616002346 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 652616002347 catalytic residue [active] 652616002348 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 652616002349 Ferredoxin [Energy production and conversion]; Region: COG1146 652616002350 4Fe-4S binding domain; Region: Fer4; pfam00037 652616002351 ferredoxin-NADP+ reductase; Region: PLN02852 652616002352 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 652616002353 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 652616002354 putative dimer interface [polypeptide binding]; other site 652616002355 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 652616002356 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 652616002357 putative catalytic site [active] 652616002358 putative phosphate binding site [ion binding]; other site 652616002359 putative metal binding site [ion binding]; other site 652616002360 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 652616002361 dimer interface [polypeptide binding]; other site 652616002362 Citrate synthase; Region: Citrate_synt; pfam00285 652616002363 active site 652616002364 citrylCoA binding site [chemical binding]; other site 652616002365 oxalacetate/citrate binding site [chemical binding]; other site 652616002366 coenzyme A binding site [chemical binding]; other site 652616002367 catalytic triad [active] 652616002368 Predicted ATPase [General function prediction only]; Region: COG3903 652616002369 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 652616002370 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 652616002371 DNA binding residues [nucleotide binding] 652616002372 dimerization interface [polypeptide binding]; other site 652616002373 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 652616002374 cyclase homology domain; Region: CHD; cd07302 652616002375 nucleotidyl binding site; other site 652616002376 metal binding site [ion binding]; metal-binding site 652616002377 dimer interface [polypeptide binding]; other site 652616002378 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 652616002379 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 652616002380 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 652616002381 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 652616002382 AAA ATPase domain; Region: AAA_16; pfam13191 652616002383 Predicted ATPase [General function prediction only]; Region: COG3903 652616002384 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 652616002385 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 652616002386 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 652616002387 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 652616002388 dimer interface [polypeptide binding]; other site 652616002389 active site 652616002390 citrylCoA binding site [chemical binding]; other site 652616002391 NADH binding [chemical binding]; other site 652616002392 cationic pore residues; other site 652616002393 oxalacetate/citrate binding site [chemical binding]; other site 652616002394 coenzyme A binding site [chemical binding]; other site 652616002395 catalytic triad [active] 652616002396 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 652616002397 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 652616002398 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 652616002399 BON domain; Region: BON; pfam04972 652616002400 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 652616002401 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 652616002402 ligand binding site [chemical binding]; other site 652616002403 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 652616002404 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 652616002405 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 652616002406 dimerization interface [polypeptide binding]; other site 652616002407 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 652616002408 dimer interface [polypeptide binding]; other site 652616002409 phosphorylation site [posttranslational modification] 652616002410 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 652616002411 Mg2+ binding site [ion binding]; other site 652616002412 G-X-G motif; other site 652616002413 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 652616002414 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 652616002415 active site 652616002416 phosphorylation site [posttranslational modification] 652616002417 intermolecular recognition site; other site 652616002418 dimerization interface [polypeptide binding]; other site 652616002419 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 652616002420 DNA binding site [nucleotide binding] 652616002421 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 652616002422 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; COG0825 652616002423 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 652616002424 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 652616002425 substrate binding site [chemical binding]; other site 652616002426 oxyanion hole (OAH) forming residues; other site 652616002427 trimer interface [polypeptide binding]; other site 652616002428 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 652616002429 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 652616002430 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 652616002431 Beta-lactamase; Region: Beta-lactamase; pfam00144 652616002432 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 652616002433 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 652616002434 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 652616002435 Soluble P-type ATPase [General function prediction only]; Region: COG4087 652616002436 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 652616002437 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 652616002438 hydrophobic ligand binding site; other site 652616002439 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 652616002440 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 652616002441 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 652616002442 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 652616002443 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 652616002444 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 652616002445 acetyl-CoA acetyltransferase; Provisional; Region: PRK06289 652616002446 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 652616002447 active site 652616002448 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616002449 PPE family; Region: PPE; pfam00823 652616002450 PE family; Region: PE; pfam00934 652616002451 BCCT family transporter; Region: BCCT; pfam02028 652616002452 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 652616002453 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 652616002454 Coenzyme A binding pocket [chemical binding]; other site 652616002455 Transposase, Mutator family; Region: Transposase_mut; pfam00872 652616002456 MULE transposase domain; Region: MULE; pfam10551 652616002457 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 652616002458 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 652616002459 catalytic residues [active] 652616002460 catalytic nucleophile [active] 652616002461 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 652616002462 Probable transposase; Region: OrfB_IS605; pfam01385 652616002463 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 652616002464 putative active site pocket [active] 652616002465 dimerization interface [polypeptide binding]; other site 652616002466 putative catalytic residue [active] 652616002467 Phage-related replication protein [General function prediction only]; Region: COG4195 652616002468 manganese transport protein MntH; Reviewed; Region: PRK00701 652616002469 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 652616002470 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 652616002471 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 652616002472 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 652616002473 short chain dehydrogenase; Provisional; Region: PRK07814 652616002474 classical (c) SDRs; Region: SDR_c; cd05233 652616002475 NAD(P) binding site [chemical binding]; other site 652616002476 active site 652616002477 phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975 652616002478 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 652616002479 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 652616002480 dimer interface [polypeptide binding]; other site 652616002481 conserved gate region; other site 652616002482 putative PBP binding loops; other site 652616002483 ABC-ATPase subunit interface; other site 652616002484 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 652616002485 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 652616002486 dimer interface [polypeptide binding]; other site 652616002487 conserved gate region; other site 652616002488 putative PBP binding loops; other site 652616002489 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 652616002490 ABC-ATPase subunit interface; other site 652616002491 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 652616002492 Catalytic domain of Protein Kinases; Region: PKc; cd00180 652616002493 active site 652616002494 ATP binding site [chemical binding]; other site 652616002495 substrate binding site [chemical binding]; other site 652616002496 activation loop (A-loop); other site 652616002497 Uncharacterized conserved protein [Function unknown]; Region: COG3391 652616002498 NHL repeat; Region: NHL; pfam01436 652616002499 NHL repeat; Region: NHL; pfam01436 652616002500 NHL repeat; Region: NHL; pfam01436 652616002501 NHL repeat; Region: NHL; pfam01436 652616002502 NHL repeat; Region: NHL; pfam01436 652616002503 PBP superfamily domain; Region: PBP_like_2; cl17296 652616002504 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14271 652616002505 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 652616002506 Walker A/P-loop; other site 652616002507 ATP binding site [chemical binding]; other site 652616002508 Q-loop/lid; other site 652616002509 ABC transporter signature motif; other site 652616002510 Walker B; other site 652616002511 D-loop; other site 652616002512 H-loop/switch region; other site 652616002513 phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975 652616002514 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 652616002515 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 652616002516 dimer interface [polypeptide binding]; other site 652616002517 conserved gate region; other site 652616002518 putative PBP binding loops; other site 652616002519 ABC-ATPase subunit interface; other site 652616002520 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 652616002521 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 652616002522 dimer interface [polypeptide binding]; other site 652616002523 conserved gate region; other site 652616002524 putative PBP binding loops; other site 652616002525 ABC-ATPase subunit interface; other site 652616002526 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 652616002527 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 652616002528 putative DNA binding site [nucleotide binding]; other site 652616002529 putative homodimer interface [polypeptide binding]; other site 652616002530 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 652616002531 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 652616002532 nucleotide binding site [chemical binding]; other site 652616002533 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 652616002534 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 652616002535 active site 652616002536 DNA binding site [nucleotide binding] 652616002537 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 652616002538 DNA binding site [nucleotide binding] 652616002539 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 652616002540 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 652616002541 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 652616002542 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 652616002543 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 652616002544 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 652616002545 anti sigma factor interaction site; other site 652616002546 regulatory phosphorylation site [posttranslational modification]; other site 652616002547 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 652616002548 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 652616002549 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 652616002550 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 652616002551 short chain dehydrogenase; Provisional; Region: PRK08251 652616002552 classical (c) SDR, subgroup 6; Region: SDR_c6; cd05350 652616002553 putative NAD(P) binding site [chemical binding]; other site 652616002554 active site 652616002555 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 652616002556 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 652616002557 active site 652616002558 dimer interface [polypeptide binding]; other site 652616002559 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 652616002560 dimer interface [polypeptide binding]; other site 652616002561 active site 652616002562 Predicted esterase [General function prediction only]; Region: COG0627 652616002563 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 652616002564 hypothetical protein; Provisional; Region: PRK07857 652616002565 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 652616002566 Part of AAA domain; Region: AAA_19; pfam13245 652616002567 Family description; Region: UvrD_C_2; pfam13538 652616002568 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 652616002569 Peptidase family M23; Region: Peptidase_M23; pfam01551 652616002570 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 652616002571 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 652616002572 CoA-ligase; Region: Ligase_CoA; pfam00549 652616002573 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 652616002574 CoA binding domain; Region: CoA_binding; smart00881 652616002575 CoA-ligase; Region: Ligase_CoA; pfam00549 652616002576 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 652616002577 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 652616002578 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 652616002579 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 652616002580 active site 652616002581 cosubstrate binding site; other site 652616002582 substrate binding site [chemical binding]; other site 652616002583 catalytic site [active] 652616002584 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 652616002585 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 652616002586 purine monophosphate binding site [chemical binding]; other site 652616002587 dimer interface [polypeptide binding]; other site 652616002588 putative catalytic residues [active] 652616002589 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 652616002590 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 652616002591 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 652616002592 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 652616002593 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 652616002594 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 652616002595 metal ion-dependent adhesion site (MIDAS); other site 652616002596 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 652616002597 homotetrameric interface [polypeptide binding]; other site 652616002598 putative active site [active] 652616002599 metal binding site [ion binding]; metal-binding site 652616002600 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 652616002601 putative transposase OrfB; Reviewed; Region: PHA02517 652616002602 HTH-like domain; Region: HTH_21; pfam13276 652616002603 Integrase core domain; Region: rve; pfam00665 652616002604 Integrase core domain; Region: rve_3; pfam13683 652616002605 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 652616002606 Transposase; Region: HTH_Tnp_1; cl17663 652616002607 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 652616002608 Thermus thermophilus CsoR, a Cu(I)-sensing transcriptional regulator, and related domains; this domain family was previously known as part of DUF156; Region: TthCsoR-like_DUF156; cd10151 652616002609 putative homodimer interface [polypeptide binding]; other site 652616002610 putative homotetramer interface [polypeptide binding]; other site 652616002611 allosteric switch controlling residues; other site 652616002612 putative metal binding site [ion binding]; other site 652616002613 putative homodimer-homodimer interface [polypeptide binding]; other site 652616002614 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 652616002615 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 652616002616 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 652616002617 Soluble P-type ATPase [General function prediction only]; Region: COG4087 652616002618 enoyl-CoA hydratase; Provisional; Region: PRK07827 652616002619 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 652616002620 substrate binding site [chemical binding]; other site 652616002621 oxyanion hole (OAH) forming residues; other site 652616002622 trimer interface [polypeptide binding]; other site 652616002623 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 652616002624 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 652616002625 active site 652616002626 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 652616002627 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 652616002628 ATP-grasp domain; Region: ATP-grasp_4; cl17255 652616002629 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 652616002630 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 652616002631 carboxyltransferase (CT) interaction site; other site 652616002632 biotinylation site [posttranslational modification]; other site 652616002633 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 652616002634 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 652616002635 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 652616002636 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 652616002637 active site 652616002638 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 652616002639 PE family; Region: PE; pfam00934 652616002640 PE family; Region: PE; pfam00934 652616002641 Uncharacterized conserved protein [Function unknown]; Region: COG3391 652616002642 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 652616002643 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 652616002644 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 652616002645 Uncharacterized conserved protein [Function unknown]; Region: COG3391 652616002646 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 652616002647 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 652616002648 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 652616002649 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 652616002650 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 652616002651 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 652616002652 active site 652616002653 phosphorylation site [posttranslational modification] 652616002654 intermolecular recognition site; other site 652616002655 dimerization interface [polypeptide binding]; other site 652616002656 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 652616002657 DNA binding site [nucleotide binding] 652616002658 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 652616002659 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 652616002660 dimerization interface [polypeptide binding]; other site 652616002661 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 652616002662 dimer interface [polypeptide binding]; other site 652616002663 phosphorylation site [posttranslational modification] 652616002664 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 652616002665 ATP binding site [chemical binding]; other site 652616002666 Mg2+ binding site [ion binding]; other site 652616002667 G-X-G motif; other site 652616002668 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 652616002669 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 652616002670 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 652616002671 MPT binding site; other site 652616002672 trimer interface [polypeptide binding]; other site 652616002673 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 652616002674 Large-conductance mechanosensitive channel, MscL; Region: MscL; pfam01741 652616002675 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 652616002676 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 652616002677 Walker A/P-loop; other site 652616002678 ATP binding site [chemical binding]; other site 652616002679 Q-loop/lid; other site 652616002680 ABC transporter signature motif; other site 652616002681 Walker B; other site 652616002682 D-loop; other site 652616002683 H-loop/switch region; other site 652616002684 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 652616002685 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 652616002686 FtsX-like permease family; Region: FtsX; pfam02687 652616002687 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 652616002688 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 652616002689 Predicted secreted hydrolase [General function prediction only]; Region: COG5621 652616002690 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 652616002691 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 652616002692 substrate binding pocket [chemical binding]; other site 652616002693 chain length determination region; other site 652616002694 substrate-Mg2+ binding site; other site 652616002695 catalytic residues [active] 652616002696 aspartate-rich region 1; other site 652616002697 active site lid residues [active] 652616002698 aspartate-rich region 2; other site 652616002699 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 652616002700 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2331 652616002701 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 652616002702 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 652616002703 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 652616002704 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 652616002705 active site 652616002706 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 652616002707 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 652616002708 dimer interface [polypeptide binding]; other site 652616002709 putative functional site; other site 652616002710 putative MPT binding site; other site 652616002711 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 652616002712 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 652616002713 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 652616002714 S-adenosylmethionine binding site [chemical binding]; other site 652616002715 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 652616002716 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 652616002717 ligand binding site [chemical binding]; other site 652616002718 flexible hinge region; other site 652616002719 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 652616002720 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 652616002721 Coenzyme A binding pocket [chemical binding]; other site 652616002722 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 652616002723 arginine deiminase; Provisional; Region: PRK01388 652616002724 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 652616002725 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 652616002726 Predicted methyltransferases [General function prediction only]; Region: COG0313 652616002727 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 652616002728 putative SAM binding site [chemical binding]; other site 652616002729 putative homodimer interface [polypeptide binding]; other site 652616002730 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 652616002731 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 652616002732 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 652616002733 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 652616002734 active site 652616002735 HIGH motif; other site 652616002736 KMSKS motif; other site 652616002737 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 652616002738 tRNA binding surface [nucleotide binding]; other site 652616002739 anticodon binding site; other site 652616002740 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 652616002741 active site 652616002742 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 652616002743 Domain of unknown function (DUF348); Region: DUF348; pfam03990 652616002744 Domain of unknown function (DUF348); Region: DUF348; pfam03990 652616002745 G5 domain; Region: G5; pfam07501 652616002746 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 652616002747 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 652616002748 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 652616002749 S-adenosylmethionine binding site [chemical binding]; other site 652616002750 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 652616002751 Increased loss of mitochondrial DNA protein 1; Region: Ilm1; pfam10311 652616002752 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 652616002753 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 652616002754 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 652616002755 acyl-activating enzyme (AAE) consensus motif; other site 652616002756 AMP binding site [chemical binding]; other site 652616002757 active site 652616002758 CoA binding site [chemical binding]; other site 652616002759 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 652616002760 putative active site [active] 652616002761 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cl00352 652616002762 catalytic residue [active] 652616002763 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 652616002764 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 652616002765 5S rRNA interface [nucleotide binding]; other site 652616002766 CTC domain interface [polypeptide binding]; other site 652616002767 L16 interface [polypeptide binding]; other site 652616002768 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 652616002769 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 652616002770 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 652616002771 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 652616002772 active site 652616002773 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 652616002774 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 652616002775 Substrate binding site; other site 652616002776 Mg++ binding site; other site 652616002777 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 652616002778 active site 652616002779 substrate binding site [chemical binding]; other site 652616002780 CoA binding site [chemical binding]; other site 652616002781 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 652616002782 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 652616002783 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 652616002784 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 652616002785 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 652616002786 ATP binding site [chemical binding]; other site 652616002787 putative Mg++ binding site [ion binding]; other site 652616002788 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 652616002789 nucleotide binding region [chemical binding]; other site 652616002790 ATP-binding site [chemical binding]; other site 652616002791 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 652616002792 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 652616002793 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 652616002794 homodimer interface [polypeptide binding]; other site 652616002795 metal binding site [ion binding]; metal-binding site 652616002796 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 652616002797 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 652616002798 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 652616002799 N-acetyl-D-glucosamine binding site [chemical binding]; other site 652616002800 enolase; Provisional; Region: eno; PRK00077 652616002801 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 652616002802 dimer interface [polypeptide binding]; other site 652616002803 metal binding site [ion binding]; metal-binding site 652616002804 substrate binding pocket [chemical binding]; other site 652616002805 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 652616002806 Septum formation initiator; Region: DivIC; pfam04977 652616002807 Uncharacterized conserved protein [Function unknown]; Region: COG1507 652616002808 exopolyphosphatase; Region: exo_poly_only; TIGR03706 652616002809 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 652616002810 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 652616002811 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 652616002812 active site 652616002813 phosphorylation site [posttranslational modification] 652616002814 intermolecular recognition site; other site 652616002815 dimerization interface [polypeptide binding]; other site 652616002816 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 652616002817 DNA binding site [nucleotide binding] 652616002818 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 652616002819 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 652616002820 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 652616002821 Ligand Binding Site [chemical binding]; other site 652616002822 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 652616002823 dimer interface [polypeptide binding]; other site 652616002824 phosphorylation site [posttranslational modification] 652616002825 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 652616002826 ATP binding site [chemical binding]; other site 652616002827 Mg2+ binding site [ion binding]; other site 652616002828 G-X-G motif; other site 652616002829 K+-transporting ATPase, KdpA; Region: kdpA; TIGR00680 652616002830 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 652616002831 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 652616002832 Soluble P-type ATPase [General function prediction only]; Region: COG4087 652616002833 potassium-transporting ATPase subunit C; Provisional; Region: PRK14001 652616002834 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 652616002835 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 652616002836 dimer interface [polypeptide binding]; other site 652616002837 phosphorylation site [posttranslational modification] 652616002838 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 652616002839 ATP binding site [chemical binding]; other site 652616002840 Mg2+ binding site [ion binding]; other site 652616002841 G-X-G motif; other site 652616002842 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 652616002843 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 652616002844 active site 652616002845 phosphorylation site [posttranslational modification] 652616002846 intermolecular recognition site; other site 652616002847 dimerization interface [polypeptide binding]; other site 652616002848 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 652616002849 DNA binding site [nucleotide binding] 652616002850 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 652616002851 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 652616002852 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 652616002853 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 652616002854 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 652616002855 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616002856 PPE family; Region: PPE; pfam00823 652616002857 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 652616002858 PE family; Region: PE; pfam00934 652616002859 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 652616002860 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 652616002861 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 652616002862 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 652616002863 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 652616002864 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 652616002865 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 652616002866 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 652616002867 Transposase, Mutator family; Region: Transposase_mut; pfam00872 652616002868 MULE transposase domain; Region: MULE; pfam10551 652616002869 Transcriptional regulators [Transcription]; Region: MarR; COG1846 652616002870 MarR family; Region: MarR_2; pfam12802 652616002871 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 652616002872 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 652616002873 NAD(P) binding site [chemical binding]; other site 652616002874 active site 652616002875 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 652616002876 Helix-turn-helix domain; Region: HTH_17; pfam12728 652616002877 Domain of unknown function (DUF427); Region: DUF427; cl00998 652616002878 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 652616002879 Domain of unknown function (DUF222); Region: DUF222; pfam02720 652616002880 Uncharacterized conserved protein [Function unknown]; Region: COG3391 652616002881 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 652616002882 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 652616002883 dimer interface [polypeptide binding]; other site 652616002884 acyl-activating enzyme (AAE) consensus motif; other site 652616002885 putative active site [active] 652616002886 AMP binding site [chemical binding]; other site 652616002887 putative CoA binding site [chemical binding]; other site 652616002888 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 652616002889 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 652616002890 hydrophobic ligand binding site; other site 652616002891 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 652616002892 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 652616002893 putative dimer interface [polypeptide binding]; other site 652616002894 putative active site [active] 652616002895 Patatin-like phospholipase; Region: Patatin; pfam01734 652616002896 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 652616002897 nucleophile elbow; other site 652616002898 hypothetical protein; Provisional; Region: PRK10279 652616002899 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 652616002900 active site 652616002901 nucleophile elbow; other site 652616002902 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 652616002903 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 652616002904 active site residue [active] 652616002905 PE family; Region: PE; pfam00934 652616002906 Predicted membrane protein [Function unknown]; Region: COG4425 652616002907 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 652616002908 enoyl-CoA hydratase; Provisional; Region: PRK05862 652616002909 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 652616002910 substrate binding site [chemical binding]; other site 652616002911 oxyanion hole (OAH) forming residues; other site 652616002912 trimer interface [polypeptide binding]; other site 652616002913 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 652616002914 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 652616002915 substrate binding site [chemical binding]; other site 652616002916 oxyanion hole (OAH) forming residues; other site 652616002917 trimer interface [polypeptide binding]; other site 652616002918 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 652616002919 Predicted membrane protein [Function unknown]; Region: COG4760 652616002920 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 652616002921 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 652616002922 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 652616002923 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 652616002924 dimer interface [polypeptide binding]; other site 652616002925 active site 652616002926 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 652616002927 active site 652616002928 catalytic triad [active] 652616002929 oxyanion hole [active] 652616002930 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 652616002931 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 652616002932 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 652616002933 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 652616002934 dimer interface [polypeptide binding]; other site 652616002935 pyridoxal 5'-phosphate binding site [chemical binding]; other site 652616002936 catalytic residue [active] 652616002937 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 652616002938 RDD family; Region: RDD; pfam06271 652616002939 cystathionine gamma-synthase; Provisional; Region: PRK07811 652616002940 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 652616002941 homodimer interface [polypeptide binding]; other site 652616002942 substrate-cofactor binding pocket; other site 652616002943 pyridoxal 5'-phosphate binding site [chemical binding]; other site 652616002944 catalytic residue [active] 652616002945 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 652616002946 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 652616002947 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 652616002948 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 652616002949 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 652616002950 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 652616002951 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 652616002952 catalytic residues [active] 652616002953 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 652616002954 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 652616002955 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 652616002956 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 652616002957 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 652616002958 catalytic residue [active] 652616002959 putative FPP diphosphate binding site; other site 652616002960 putative FPP binding hydrophobic cleft; other site 652616002961 dimer interface [polypeptide binding]; other site 652616002962 putative IPP diphosphate binding site; other site 652616002963 PE family; Region: PE; pfam00934 652616002964 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 652616002965 putative IPP diphosphate binding site; other site 652616002966 PE family; Region: PE; pfam00934 652616002967 Cellulose binding domain; Region: CBM_2; cl17741 652616002968 Glycosyl hydrolase family 12; Region: Glyco_hydro_12; pfam01670 652616002969 PE family; Region: PE; pfam00934 652616002970 pantothenate kinase; Provisional; Region: PRK05439 652616002971 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 652616002972 ATP-binding site [chemical binding]; other site 652616002973 CoA-binding site [chemical binding]; other site 652616002974 Mg2+-binding site [ion binding]; other site 652616002975 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 652616002976 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 652616002977 dimer interface [polypeptide binding]; other site 652616002978 active site 652616002979 glycine-pyridoxal phosphate binding site [chemical binding]; other site 652616002980 folate binding site [chemical binding]; other site 652616002981 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 652616002982 dinuclear metal binding motif [ion binding]; other site 652616002983 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 652616002984 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 652616002985 putative active site [active] 652616002986 PhoH-like protein; Region: PhoH; pfam02562 652616002987 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 652616002988 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 652616002989 NodB motif; other site 652616002990 active site 652616002991 catalytic site [active] 652616002992 metal binding site [ion binding]; metal-binding site 652616002993 fumarate hydratase; Reviewed; Region: fumC; PRK00485 652616002994 Class II fumarases; Region: Fumarase_classII; cd01362 652616002995 active site 652616002996 tetramer interface [polypeptide binding]; other site 652616002997 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 652616002998 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 652616002999 putative active site [active] 652616003000 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 652616003001 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 652616003002 Domain of unknown function DUF20; Region: UPF0118; pfam01594 652616003003 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 652616003004 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 652616003005 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 652616003006 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 652616003007 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 652616003008 3beta-hydroxysteroid dehydrogenases (3b-HSD)-like, extended (e) SDRs; Region: 3b-HSD-like_SDR_e; cd05241 652616003009 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 652616003010 putative NAD(P) binding site [chemical binding]; other site 652616003011 active site 652616003012 putative substrate binding site [chemical binding]; other site 652616003013 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 652616003014 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 652616003015 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 652616003016 generic binding surface II; other site 652616003017 generic binding surface I; other site 652616003018 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 652616003019 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 652616003020 GTP-binding protein YchF; Reviewed; Region: PRK09601 652616003021 YchF GTPase; Region: YchF; cd01900 652616003022 G1 box; other site 652616003023 GTP/Mg2+ binding site [chemical binding]; other site 652616003024 Switch I region; other site 652616003025 G2 box; other site 652616003026 Switch II region; other site 652616003027 G3 box; other site 652616003028 G4 box; other site 652616003029 G5 box; other site 652616003030 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 652616003031 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 652616003032 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487 652616003033 putative active site [active] 652616003034 Uncharacterized conserved protein [Function unknown]; Region: COG1359 652616003035 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 652616003036 cyclase homology domain; Region: CHD; cd07302 652616003037 nucleotidyl binding site; other site 652616003038 metal binding site [ion binding]; metal-binding site 652616003039 dimer interface [polypeptide binding]; other site 652616003040 glucose-6-phosphate 1-dehydrogenase; Region: zwf; TIGR00871 652616003041 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 652616003042 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 652616003043 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 652616003044 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd_rel; TIGR00872 652616003045 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 652616003046 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 652616003047 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 652616003048 pyruvate phosphate dikinase; Provisional; Region: PRK05878 652616003049 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 652616003050 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 652616003051 Domain of unknown function (DUF222); Region: DUF222; pfam02720 652616003052 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 652616003053 active site 652616003054 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 652616003055 sequence-specific DNA binding site [nucleotide binding]; other site 652616003056 salt bridge; other site 652616003057 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 652616003058 Domain of unknown function (DUF955); Region: DUF955; pfam06114 652616003059 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 652616003060 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 652616003061 citrate synthase; Provisional; Region: PRK14033 652616003062 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 652616003063 oxalacetate binding site [chemical binding]; other site 652616003064 citrylCoA binding site [chemical binding]; other site 652616003065 coenzyme A binding site [chemical binding]; other site 652616003066 catalytic triad [active] 652616003067 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 652616003068 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 652616003069 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 652616003070 THF binding site; other site 652616003071 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 652616003072 substrate binding site [chemical binding]; other site 652616003073 THF binding site; other site 652616003074 zinc-binding site [ion binding]; other site 652616003075 PPE family; Region: PPE; pfam00823 652616003076 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 652616003077 active site 652616003078 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 652616003079 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 652616003080 substrate binding site [chemical binding]; other site 652616003081 oxyanion hole (OAH) forming residues; other site 652616003082 enoyl-CoA hydratase; Provisional; Region: PRK06494 652616003083 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 652616003084 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 652616003085 CAAX protease self-immunity; Region: Abi; pfam02517 652616003086 enoyl-CoA hydratase; Provisional; Region: PRK06688 652616003087 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 652616003088 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 652616003089 trimer interface [polypeptide binding]; other site 652616003090 enoyl-CoA hydratase; Provisional; Region: PRK06688 652616003091 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 652616003092 substrate binding site [chemical binding]; other site 652616003093 oxyanion hole (OAH) forming residues; other site 652616003094 trimer interface [polypeptide binding]; other site 652616003095 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 652616003096 CoA-transferase family III; Region: CoA_transf_3; pfam02515 652616003097 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 652616003098 NAD binding site [chemical binding]; other site 652616003099 homodimer interface [polypeptide binding]; other site 652616003100 homotetramer interface [polypeptide binding]; other site 652616003101 active site 652616003102 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 652616003103 MMPL family; Region: MMPL; pfam03176 652616003104 DDE superfamily endonuclease; Region: DDE_5; cl17874 652616003105 Domain of unknown function (DUF222); Region: DUF222; pfam02720 652616003106 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 652616003107 active site 652616003108 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 652616003109 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 652616003110 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 652616003111 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 652616003112 NAD-dependent deacetylase; Provisional; Region: PRK00481 652616003113 NAD+ binding site [chemical binding]; other site 652616003114 substrate binding site [chemical binding]; other site 652616003115 Zn binding site [ion binding]; other site 652616003116 Predicted transcriptional regulators [Transcription]; Region: COG1725 652616003117 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 652616003118 DNA-binding site [nucleotide binding]; DNA binding site 652616003119 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 652616003120 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 652616003121 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 652616003122 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 652616003123 uncharacterized HhH-GPD family protein; Region: TIGR03252 652616003124 minor groove reading motif; other site 652616003125 helix-hairpin-helix signature motif; other site 652616003126 mannosyltransferase; Provisional; Region: pimE; PRK13375 652616003127 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 652616003128 aromatic arch; other site 652616003129 DCoH dimer interaction site [polypeptide binding]; other site 652616003130 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 652616003131 DCoH tetramer interaction site [polypeptide binding]; other site 652616003132 substrate binding site [chemical binding]; other site 652616003133 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 652616003134 active site 652616003135 8-oxo-dGMP binding site [chemical binding]; other site 652616003136 nudix motif; other site 652616003137 metal binding site [ion binding]; metal-binding site 652616003138 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 652616003139 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 652616003140 [4Fe-4S] binding site [ion binding]; other site 652616003141 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 652616003142 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 652616003143 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 652616003144 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 652616003145 molybdopterin cofactor binding site; other site 652616003146 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 652616003147 nitrate reductase molybdenum cofactor assembly chaperone; Region: narJ; TIGR00684 652616003148 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 652616003149 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 652616003150 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 652616003151 G1 box; other site 652616003152 putative GEF interaction site [polypeptide binding]; other site 652616003153 GTP/Mg2+ binding site [chemical binding]; other site 652616003154 Switch I region; other site 652616003155 G2 box; other site 652616003156 G3 box; other site 652616003157 Switch II region; other site 652616003158 G4 box; other site 652616003159 G5 box; other site 652616003160 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 652616003161 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 652616003162 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 652616003163 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 652616003164 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 652616003165 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 652616003166 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 652616003167 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616003168 PPE family; Region: PPE; pfam00823 652616003169 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 652616003170 PE family; Region: PE; pfam00934 652616003171 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 652616003172 PE family; Region: PE; pfam00934 652616003173 FO synthase; Reviewed; Region: fbiC; PRK09234 652616003174 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 652616003175 FeS/SAM binding site; other site 652616003176 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 652616003177 FeS/SAM binding site; other site 652616003178 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 652616003179 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 652616003180 active site 652616003181 FMN binding site [chemical binding]; other site 652616003182 2,4-decadienoyl-CoA binding site; other site 652616003183 catalytic residue [active] 652616003184 4Fe-4S cluster binding site [ion binding]; other site 652616003185 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 652616003186 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 652616003187 Predicted transcriptional regulators [Transcription]; Region: COG1695 652616003188 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 652616003189 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 652616003190 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 652616003191 4Fe-4S binding domain; Region: Fer4; pfam00037 652616003192 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 652616003193 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 652616003194 pyridoxal 5'-phosphate binding site [chemical binding]; other site 652616003195 homodimer interface [polypeptide binding]; other site 652616003196 catalytic residue [active] 652616003197 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 652616003198 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 652616003199 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 652616003200 ATP binding site [chemical binding]; other site 652616003201 putative Mg++ binding site [ion binding]; other site 652616003202 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 652616003203 ATP-binding site [chemical binding]; other site 652616003204 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 652616003205 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 652616003206 active site 652616003207 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 652616003208 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 652616003209 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 652616003210 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 652616003211 Enoylreductase; Region: PKS_ER; smart00829 652616003212 NAD(P) binding site [chemical binding]; other site 652616003213 KR domain; Region: KR; pfam08659 652616003214 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 652616003215 putative NADP binding site [chemical binding]; other site 652616003216 active site 652616003217 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 652616003218 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 652616003219 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 652616003220 PE-PPE domain; Region: PE-PPE; pfam08237 652616003221 acyl-CoA synthetase; Validated; Region: PRK05850 652616003222 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 652616003223 acyl-activating enzyme (AAE) consensus motif; other site 652616003224 active site 652616003225 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 652616003226 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 652616003227 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 652616003228 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 652616003229 Glutamate binding site [chemical binding]; other site 652616003230 NAD binding site [chemical binding]; other site 652616003231 catalytic residues [active] 652616003232 Proline dehydrogenase; Region: Pro_dh; pfam01619 652616003233 RNA polymerase sigma factor SigI; Provisional; Region: sigI; PRK09635 652616003234 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 652616003235 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 652616003236 DNA binding residues [nucleotide binding] 652616003237 haloalkane dehalogenase; Provisional; Region: PRK03204 652616003238 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 652616003239 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 652616003240 catalytic site [active] 652616003241 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 652616003242 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 652616003243 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 652616003244 PGAP1-like protein; Region: PGAP1; pfam07819 652616003245 acyl-CoA synthetase; Validated; Region: PRK07787 652616003246 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 652616003247 acyl-activating enzyme (AAE) consensus motif; other site 652616003248 AMP binding site [chemical binding]; other site 652616003249 active site 652616003250 CoA binding site [chemical binding]; other site 652616003251 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 652616003252 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 652616003253 PE family; Region: PE; pfam00934 652616003254 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616003255 PPE family; Region: PPE; pfam00823 652616003256 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 652616003257 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 652616003258 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 652616003259 Transposase, Mutator family; Region: Transposase_mut; pfam00872 652616003260 MULE transposase domain; Region: MULE; pfam10551 652616003261 metabolite-proton symporter; Region: 2A0106; TIGR00883 652616003262 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 652616003263 putative substrate translocation pore; other site 652616003264 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 652616003265 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 652616003266 putative trimer interface [polypeptide binding]; other site 652616003267 putative CoA binding site [chemical binding]; other site 652616003268 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 652616003269 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 652616003270 metal binding site [ion binding]; metal-binding site 652616003271 putative dimer interface [polypeptide binding]; other site 652616003272 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 652616003273 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 652616003274 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 652616003275 acyl-activating enzyme (AAE) consensus motif; other site 652616003276 putative AMP binding site [chemical binding]; other site 652616003277 putative active site [active] 652616003278 putative CoA binding site [chemical binding]; other site 652616003279 dihydropteroate synthase; Region: DHPS; TIGR01496 652616003280 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 652616003281 substrate binding pocket [chemical binding]; other site 652616003282 dimer interface [polypeptide binding]; other site 652616003283 inhibitor binding site; inhibition site 652616003284 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 652616003285 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 652616003286 DivIVA domain; Region: DivI1A_domain; TIGR03544 652616003287 DNA-3-methyladenine glycosylase I; Region: tag; TIGR00624 652616003288 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 652616003289 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 652616003290 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 652616003291 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 652616003292 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 652616003293 ligand binding site; other site 652616003294 oligomer interface; other site 652616003295 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 652616003296 dimer interface [polypeptide binding]; other site 652616003297 N-terminal domain interface [polypeptide binding]; other site 652616003298 sulfate 1 binding site; other site 652616003299 PE family; Region: PE; pfam00934 652616003300 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 652616003301 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 652616003302 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 652616003303 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 652616003304 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 652616003305 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 652616003306 Walker A/P-loop; other site 652616003307 ATP binding site [chemical binding]; other site 652616003308 Q-loop/lid; other site 652616003309 ABC transporter signature motif; other site 652616003310 Walker B; other site 652616003311 D-loop; other site 652616003312 H-loop/switch region; other site 652616003313 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 652616003314 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 652616003315 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 652616003316 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 652616003317 S-adenosylmethionine binding site [chemical binding]; other site 652616003318 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 652616003319 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 652616003320 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 652616003321 DNA binding residues [nucleotide binding] 652616003322 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 652616003323 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 652616003324 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 652616003325 protein binding site [polypeptide binding]; other site 652616003326 sec-independent translocase; Provisional; Region: PRK03100 652616003327 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 652616003328 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 652616003329 active site 652616003330 motif I; other site 652616003331 motif II; other site 652616003332 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 652616003333 Predicted membrane protein [Function unknown]; Region: COG3428 652616003334 Bacterial PH domain; Region: DUF304; pfam03703 652616003335 Uncharacterized conserved protein [Function unknown]; Region: COG3402 652616003336 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 652616003337 Domain of unknown function DUF59; Region: DUF59; cl00941 652616003338 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 652616003339 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 652616003340 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 652616003341 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 652616003342 N-acetyl-D-glucosamine binding site [chemical binding]; other site 652616003343 catalytic residue [active] 652616003344 Predicted membrane protein [Function unknown]; Region: COG4420 652616003345 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 652616003346 MgtE intracellular N domain; Region: MgtE_N; smart00924 652616003347 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 652616003348 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 652616003349 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 652616003350 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 652616003351 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 652616003352 dimer interface [polypeptide binding]; other site 652616003353 conserved gate region; other site 652616003354 putative PBP binding loops; other site 652616003355 ABC-ATPase subunit interface; other site 652616003356 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 652616003357 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 652616003358 dimer interface [polypeptide binding]; other site 652616003359 conserved gate region; other site 652616003360 ABC-ATPase subunit interface; other site 652616003361 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 652616003362 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 652616003363 Walker A/P-loop; other site 652616003364 ATP binding site [chemical binding]; other site 652616003365 Q-loop/lid; other site 652616003366 ABC transporter signature motif; other site 652616003367 Walker B; other site 652616003368 D-loop; other site 652616003369 H-loop/switch region; other site 652616003370 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 652616003371 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 652616003372 oligomer interface [polypeptide binding]; other site 652616003373 metal binding site [ion binding]; metal-binding site 652616003374 metal binding site [ion binding]; metal-binding site 652616003375 putative Cl binding site [ion binding]; other site 652616003376 basic sphincter; other site 652616003377 hydrophobic gate; other site 652616003378 periplasmic entrance; other site 652616003379 malate dehydrogenase; Provisional; Region: PRK05442 652616003380 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 652616003381 NAD(P) binding site [chemical binding]; other site 652616003382 dimer interface [polypeptide binding]; other site 652616003383 malate binding site [chemical binding]; other site 652616003384 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 652616003385 PE family; Region: PE; pfam00934 652616003386 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 652616003387 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 652616003388 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 652616003389 NAD(P) binding site [chemical binding]; other site 652616003390 active site 652616003391 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 652616003392 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 652616003393 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 652616003394 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 652616003395 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 652616003396 TPP-binding site [chemical binding]; other site 652616003397 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 652616003398 dimer interface [polypeptide binding]; other site 652616003399 PYR/PP interface [polypeptide binding]; other site 652616003400 TPP binding site [chemical binding]; other site 652616003401 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 652616003402 RNase_H superfamily; Region: RNase_H_2; pfam13482 652616003403 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 652616003404 Part of AAA domain; Region: AAA_19; pfam13245 652616003405 AAA domain; Region: AAA_12; pfam13087 652616003406 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 652616003407 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 652616003408 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 652616003409 ATP binding site [chemical binding]; other site 652616003410 Mg++ binding site [ion binding]; other site 652616003411 motif III; other site 652616003412 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 652616003413 nucleotide binding region [chemical binding]; other site 652616003414 ATP-binding site [chemical binding]; other site 652616003415 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 652616003416 putative RNA binding site [nucleotide binding]; other site 652616003417 Acyltransferase family; Region: Acyl_transf_3; pfam01757 652616003418 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 652616003419 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 652616003420 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 652616003421 FAD binding domain; Region: FAD_binding_4; pfam01565 652616003422 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 652616003423 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 652616003424 H+ Antiporter protein; Region: 2A0121; TIGR00900 652616003425 putative substrate translocation pore; other site 652616003426 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 652616003427 Fe-S cluster binding site [ion binding]; other site 652616003428 DNA binding site [nucleotide binding] 652616003429 active site 652616003430 hypothetical protein; Validated; Region: PRK05868 652616003431 hypothetical protein; Provisional; Region: PRK07236 652616003432 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 652616003433 Domain of unknown function (DUF385); Region: DUF385; pfam04075 652616003434 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 652616003435 HIT family signature motif; other site 652616003436 catalytic residue [active] 652616003437 amidase; Provisional; Region: PRK12470 652616003438 Amidase; Region: Amidase; pfam01425 652616003439 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 652616003440 cyclase homology domain; Region: CHD; cd07302 652616003441 nucleotidyl binding site; other site 652616003442 metal binding site [ion binding]; metal-binding site 652616003443 dimer interface [polypeptide binding]; other site 652616003444 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 652616003445 Catalytic domain of Protein Kinases; Region: PKc; cd00180 652616003446 active site 652616003447 ATP binding site [chemical binding]; other site 652616003448 substrate binding site [chemical binding]; other site 652616003449 activation loop (A-loop); other site 652616003450 PknH-like extracellular domain; Region: PknH_C; pfam14032 652616003451 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 652616003452 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 652616003453 DNA binding site [nucleotide binding] 652616003454 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 652616003455 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 652616003456 phosphopeptide binding site; other site 652616003457 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 652616003458 putative active site [active] 652616003459 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 652616003460 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 652616003461 Protein of unknown function (DUF732); Region: DUF732; pfam05305 652616003462 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 652616003463 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 652616003464 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 652616003465 Walker A/P-loop; other site 652616003466 ATP binding site [chemical binding]; other site 652616003467 Q-loop/lid; other site 652616003468 ABC transporter signature motif; other site 652616003469 Walker B; other site 652616003470 D-loop; other site 652616003471 H-loop/switch region; other site 652616003472 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 652616003473 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 652616003474 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 652616003475 Walker A/P-loop; other site 652616003476 ATP binding site [chemical binding]; other site 652616003477 Q-loop/lid; other site 652616003478 ABC transporter signature motif; other site 652616003479 Walker B; other site 652616003480 D-loop; other site 652616003481 H-loop/switch region; other site 652616003482 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 652616003483 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 652616003484 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 652616003485 catalytic core [active] 652616003486 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 652616003487 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 652616003488 active site 652616003489 metal binding site [ion binding]; metal-binding site 652616003490 DNA binding site [nucleotide binding] 652616003491 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 652616003492 Walker A/P-loop; other site 652616003493 ATP binding site [chemical binding]; other site 652616003494 choline dehydrogenase; Validated; Region: PRK02106 652616003495 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 652616003496 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 652616003497 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 652616003498 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 652616003499 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 652616003500 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 652616003501 Walker A/P-loop; other site 652616003502 ATP binding site [chemical binding]; other site 652616003503 Q-loop/lid; other site 652616003504 ABC transporter signature motif; other site 652616003505 Walker B; other site 652616003506 D-loop; other site 652616003507 H-loop/switch region; other site 652616003508 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 652616003509 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 652616003510 Walker A/P-loop; other site 652616003511 ATP binding site [chemical binding]; other site 652616003512 Q-loop/lid; other site 652616003513 ABC transporter signature motif; other site 652616003514 Walker B; other site 652616003515 D-loop; other site 652616003516 H-loop/switch region; other site 652616003517 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 652616003518 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 652616003519 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 652616003520 dimer interface [polypeptide binding]; other site 652616003521 conserved gate region; other site 652616003522 putative PBP binding loops; other site 652616003523 ABC-ATPase subunit interface; other site 652616003524 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 652616003525 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 652616003526 dimer interface [polypeptide binding]; other site 652616003527 conserved gate region; other site 652616003528 putative PBP binding loops; other site 652616003529 ABC-ATPase subunit interface; other site 652616003530 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 652616003531 active site clefts [active] 652616003532 zinc binding site [ion binding]; other site 652616003533 dimer interface [polypeptide binding]; other site 652616003534 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 652616003535 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 652616003536 Active Sites [active] 652616003537 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 652616003538 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 652616003539 CysD dimerization site [polypeptide binding]; other site 652616003540 G1 box; other site 652616003541 putative GEF interaction site [polypeptide binding]; other site 652616003542 GTP/Mg2+ binding site [chemical binding]; other site 652616003543 Switch I region; other site 652616003544 G2 box; other site 652616003545 G3 box; other site 652616003546 Switch II region; other site 652616003547 G4 box; other site 652616003548 G5 box; other site 652616003549 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 652616003550 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 652616003551 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 652616003552 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 652616003553 Walker A/P-loop; other site 652616003554 ligand-binding site [chemical binding]; other site 652616003555 ATP binding site [chemical binding]; other site 652616003556 Rrf2 family protein; Region: rrf2_super; TIGR00738 652616003557 Transcriptional regulator; Region: Rrf2; pfam02082 652616003558 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 652616003559 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 652616003560 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 652616003561 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 652616003562 Putative esterase; Region: Esterase; pfam00756 652616003563 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 652616003564 Predicted membrane protein [Function unknown]; Region: COG4325 652616003565 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 652616003566 Protein of unknown function (DUF732); Region: DUF732; pfam05305 652616003567 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 652616003568 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 652616003569 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 652616003570 active site 652616003571 HIGH motif; other site 652616003572 KMSK motif region; other site 652616003573 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 652616003574 tRNA binding surface [nucleotide binding]; other site 652616003575 anticodon binding site; other site 652616003576 diaminopimelate decarboxylase; Region: lysA; TIGR01048 652616003577 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 652616003578 active site 652616003579 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 652616003580 substrate binding site [chemical binding]; other site 652616003581 catalytic residues [active] 652616003582 dimer interface [polypeptide binding]; other site 652616003583 homoserine dehydrogenase; Provisional; Region: PRK06349 652616003584 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 652616003585 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 652616003586 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 652616003587 threonine synthase; Reviewed; Region: PRK06721 652616003588 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 652616003589 homodimer interface [polypeptide binding]; other site 652616003590 pyridoxal 5'-phosphate binding site [chemical binding]; other site 652616003591 catalytic residue [active] 652616003592 Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083 652616003593 transcription termination factor Rho; Provisional; Region: PRK12678 652616003594 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 652616003595 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 652616003596 RNA binding site [nucleotide binding]; other site 652616003597 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 652616003598 multimer interface [polypeptide binding]; other site 652616003599 Walker A motif; other site 652616003600 ATP binding site [chemical binding]; other site 652616003601 Walker B motif; other site 652616003602 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 652616003603 peptide chain release factor 1; Region: prfA; TIGR00019 652616003604 This domain is found in peptide chain release factors; Region: PCRF; smart00937 652616003605 RF-1 domain; Region: RF-1; pfam00472 652616003606 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 652616003607 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 652616003608 S-adenosylmethionine binding site [chemical binding]; other site 652616003609 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 652616003610 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 652616003611 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 652616003612 Mg++ binding site [ion binding]; other site 652616003613 putative catalytic motif [active] 652616003614 substrate binding site [chemical binding]; other site 652616003615 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 652616003616 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 652616003617 F0F1 ATP synthase subunit C; Validated; Region: PRK05880 652616003618 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 652616003619 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 652616003620 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13428 652616003621 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 652616003622 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 652616003623 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 652616003624 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 652616003625 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 652616003626 Walker A motif; other site 652616003627 ATP binding site [chemical binding]; other site 652616003628 Walker B motif; other site 652616003629 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 652616003630 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 652616003631 core domain interface [polypeptide binding]; other site 652616003632 delta subunit interface [polypeptide binding]; other site 652616003633 epsilon subunit interface [polypeptide binding]; other site 652616003634 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 652616003635 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 652616003636 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 652616003637 alpha subunit interaction interface [polypeptide binding]; other site 652616003638 Walker A motif; other site 652616003639 ATP binding site [chemical binding]; other site 652616003640 Walker B motif; other site 652616003641 inhibitor binding site; inhibition site 652616003642 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 652616003643 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 652616003644 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 652616003645 gamma subunit interface [polypeptide binding]; other site 652616003646 epsilon subunit interface [polypeptide binding]; other site 652616003647 LBP interface [polypeptide binding]; other site 652616003648 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 652616003649 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 652616003650 Transposase; Region: DDE_Tnp_ISL3; pfam01610 652616003651 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 652616003652 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 652616003653 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 652616003654 hinge; other site 652616003655 active site 652616003656 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 652616003657 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 652616003658 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 652616003659 DNA binding site [nucleotide binding] 652616003660 active site 652616003661 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 652616003662 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 652616003663 AlkA N-terminal domain; Region: AlkA_N; pfam06029 652616003664 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 652616003665 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 652616003666 minor groove reading motif; other site 652616003667 helix-hairpin-helix signature motif; other site 652616003668 substrate binding pocket [chemical binding]; other site 652616003669 active site 652616003670 HAMP domain; Region: HAMP; pfam00672 652616003671 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 652616003672 cyclase homology domain; Region: CHD; cd07302 652616003673 nucleotidyl binding site; other site 652616003674 metal binding site [ion binding]; metal-binding site 652616003675 dimer interface [polypeptide binding]; other site 652616003676 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 652616003677 dimerization interface [polypeptide binding]; other site 652616003678 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 652616003679 cyclase homology domain; Region: CHD; cd07302 652616003680 nucleotidyl binding site; other site 652616003681 metal binding site [ion binding]; metal-binding site 652616003682 dimer interface [polypeptide binding]; other site 652616003683 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 652616003684 dimerization interface [polypeptide binding]; other site 652616003685 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 652616003686 cyclase homology domain; Region: CHD; cd07302 652616003687 nucleotidyl binding site; other site 652616003688 metal binding site [ion binding]; metal-binding site 652616003689 dimer interface [polypeptide binding]; other site 652616003690 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 652616003691 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 652616003692 dimerization interface [polypeptide binding]; other site 652616003693 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 652616003694 cyclase homology domain; Region: CHD; cd07302 652616003695 nucleotidyl binding site; other site 652616003696 metal binding site [ion binding]; metal-binding site 652616003697 dimer interface [polypeptide binding]; other site 652616003698 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 652616003699 hypothetical protein; Provisional; Region: PRK03298 652616003700 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 652616003701 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 652616003702 dimer interface [polypeptide binding]; other site 652616003703 substrate binding site [chemical binding]; other site 652616003704 metal binding site [ion binding]; metal-binding site 652616003705 putative acyltransferase; Provisional; Region: PRK05790 652616003706 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 652616003707 dimer interface [polypeptide binding]; other site 652616003708 active site 652616003709 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 652616003710 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 652616003711 PE family; Region: PE; pfam00934 652616003712 glycogen branching enzyme; Provisional; Region: PRK05402 652616003713 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 652616003714 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 652616003715 active site 652616003716 catalytic site [active] 652616003717 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 652616003718 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 652616003719 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 652616003720 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 652616003721 active site 652616003722 homodimer interface [polypeptide binding]; other site 652616003723 catalytic site [active] 652616003724 acceptor binding site [chemical binding]; other site 652616003725 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 652616003726 putative homodimer interface [polypeptide binding]; other site 652616003727 putative active site pocket [active] 652616003728 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 652616003729 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 652616003730 DEAD/DEAH box helicase; Region: DEAD; pfam00270 652616003731 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 652616003732 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 652616003733 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 652616003734 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 652616003735 active site 652616003736 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 652616003737 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 652616003738 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 652616003739 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 652616003740 putative active site pocket [active] 652616003741 cleavage site 652616003742 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 652616003743 MPN+ (JAMM) motif; other site 652616003744 Zinc-binding site [ion binding]; other site 652616003745 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 652616003746 MoaE interaction surface [polypeptide binding]; other site 652616003747 MoeB interaction surface [polypeptide binding]; other site 652616003748 thiocarboxylated glycine; other site 652616003749 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 652616003750 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 652616003751 dimer interface [polypeptide binding]; other site 652616003752 pyridoxal 5'-phosphate binding site [chemical binding]; other site 652616003753 catalytic residue [active] 652616003754 Rhomboid family; Region: Rhomboid; cl11446 652616003755 glutamate racemase; Provisional; Region: PRK00865 652616003756 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 652616003757 ribonuclease PH; Reviewed; Region: rph; PRK00173 652616003758 Ribonuclease PH; Region: RNase_PH_bact; cd11362 652616003759 hexamer interface [polypeptide binding]; other site 652616003760 active site 652616003761 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 652616003762 active site 652616003763 dimerization interface [polypeptide binding]; other site 652616003764 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 652616003765 Glucitol operon activator [Transcription]; Region: GutM; COG4578 652616003766 acyl carrier protein; Validated; Region: PRK05883 652616003767 long-chain-fatty-acid--[acyl-carrier-protein] ligase; Validated; Region: PRK05851 652616003768 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 652616003769 acyl-activating enzyme (AAE) consensus motif; other site 652616003770 active site 652616003771 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 652616003772 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 652616003773 active site 652616003774 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 652616003775 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 652616003776 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 652616003777 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 652616003778 FAD binding pocket [chemical binding]; other site 652616003779 FAD binding motif [chemical binding]; other site 652616003780 phosphate binding motif [ion binding]; other site 652616003781 NAD binding pocket [chemical binding]; other site 652616003782 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 652616003783 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 652616003784 Walker A/P-loop; other site 652616003785 ATP binding site [chemical binding]; other site 652616003786 Q-loop/lid; other site 652616003787 ABC transporter signature motif; other site 652616003788 Walker B; other site 652616003789 D-loop; other site 652616003790 H-loop/switch region; other site 652616003791 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 652616003792 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 652616003793 Walker A/P-loop; other site 652616003794 ATP binding site [chemical binding]; other site 652616003795 Q-loop/lid; other site 652616003796 ABC transporter signature motif; other site 652616003797 Walker B; other site 652616003798 D-loop; other site 652616003799 H-loop/switch region; other site 652616003800 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 652616003801 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 652616003802 NAD(P) binding site [chemical binding]; other site 652616003803 active site 652616003804 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 652616003805 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 652616003806 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 652616003807 cyclase homology domain; Region: CHD; cd07302 652616003808 nucleotidyl binding site; other site 652616003809 dimer interface [polypeptide binding]; other site 652616003810 metal binding site [ion binding]; metal-binding site 652616003811 AAA ATPase domain; Region: AAA_16; pfam13191 652616003812 Predicted ATPase [General function prediction only]; Region: COG3903 652616003813 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 652616003814 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 652616003815 DNA binding residues [nucleotide binding] 652616003816 dimerization interface [polypeptide binding]; other site 652616003817 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 652616003818 cyclase homology domain; Region: CHD; cd07302 652616003819 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 652616003820 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 652616003821 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616003822 PPE family; Region: PPE; pfam00823 652616003823 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 652616003824 PAS fold; Region: PAS_4; pfam08448 652616003825 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 652616003826 putative active site [active] 652616003827 heme pocket [chemical binding]; other site 652616003828 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 652616003829 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 652616003830 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 652616003831 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 652616003832 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 652616003833 anti sigma factor interaction site; other site 652616003834 regulatory phosphorylation site [posttranslational modification]; other site 652616003835 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 652616003836 anti sigma factor interaction site; other site 652616003837 regulatory phosphorylation site [posttranslational modification]; other site 652616003838 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 652616003839 synthetase active site [active] 652616003840 NTP binding site [chemical binding]; other site 652616003841 metal binding site [ion binding]; metal-binding site 652616003842 Beta-lactamase; Region: Beta-lactamase; pfam00144 652616003843 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 652616003844 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 652616003845 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; pfam00173 652616003846 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 652616003847 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 652616003848 putative di-iron ligands [ion binding]; other site 652616003849 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 652616003850 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 652616003851 malonyl-CoA binding site [chemical binding]; other site 652616003852 dimer interface [polypeptide binding]; other site 652616003853 active site 652616003854 product binding site; other site 652616003855 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 652616003856 uncharacterized domain; Region: TIGR00702 652616003857 YcaO-like family; Region: YcaO; pfam02624 652616003858 Uncharacterized conserved protein [Function unknown]; Region: COG3482 652616003859 Domain of unknown function (DUF222); Region: DUF222; pfam02720 652616003860 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 652616003861 active site 652616003862 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 652616003863 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 652616003864 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 652616003865 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 652616003866 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 652616003867 dihydroorotase; Validated; Region: pyrC; PRK09357 652616003868 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 652616003869 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 652616003870 active site 652616003871 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 652616003872 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 652616003873 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 652616003874 catalytic site [active] 652616003875 subunit interface [polypeptide binding]; other site 652616003876 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 652616003877 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 652616003878 ATP-grasp domain; Region: ATP-grasp_4; cl17255 652616003879 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 652616003880 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 652616003881 ATP-grasp domain; Region: ATP-grasp_4; cl17255 652616003882 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 652616003883 IMP binding site; other site 652616003884 dimer interface [polypeptide binding]; other site 652616003885 interdomain contacts; other site 652616003886 partial ornithine binding site; other site 652616003887 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 652616003888 active site 652616003889 dimer interface [polypeptide binding]; other site 652616003890 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616003891 PPE family; Region: PPE; pfam00823 652616003892 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 652616003893 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 652616003894 catalytic site [active] 652616003895 G-X2-G-X-G-K; other site 652616003896 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 652616003897 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 652616003898 Flavoprotein; Region: Flavoprotein; pfam02441 652616003899 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 652616003900 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 652616003901 S-adenosylmethionine synthetase; Validated; Region: PRK05250 652616003902 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 652616003903 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 652616003904 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 652616003905 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 652616003906 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 652616003907 Cytochrome P450; Region: p450; cl12078 652616003908 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 652616003909 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 652616003910 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 652616003911 PE family; Region: PE; pfam00934 652616003912 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 652616003913 oligomeric interface; other site 652616003914 putative active site [active] 652616003915 homodimer interface [polypeptide binding]; other site 652616003916 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 652616003917 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 652616003918 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 652616003919 substrate binding pocket [chemical binding]; other site 652616003920 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 652616003921 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 652616003922 substrate binding pocket [chemical binding]; other site 652616003923 Predicted membrane protein [Function unknown]; Region: COG3714 652616003924 primosome assembly protein PriA; Provisional; Region: PRK14873 652616003925 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 652616003926 S-adenosylmethionine binding site [chemical binding]; other site 652616003927 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 652616003928 MarR family; Region: MarR; pfam01047 652616003929 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 652616003930 S-adenosylmethionine binding site [chemical binding]; other site 652616003931 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 652616003932 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 652616003933 putative active site [active] 652616003934 substrate binding site [chemical binding]; other site 652616003935 putative cosubstrate binding site; other site 652616003936 catalytic site [active] 652616003937 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 652616003938 substrate binding site [chemical binding]; other site 652616003939 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 652616003940 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 652616003941 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 652616003942 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 652616003943 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 652616003944 substrate binding site [chemical binding]; other site 652616003945 hexamer interface [polypeptide binding]; other site 652616003946 metal binding site [ion binding]; metal-binding site 652616003947 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 652616003948 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 652616003949 catalytic motif [active] 652616003950 Zn binding site [ion binding]; other site 652616003951 RibD C-terminal domain; Region: RibD_C; pfam01872 652616003952 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 652616003953 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 652616003954 putative substrate translocation pore; other site 652616003955 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 652616003956 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 652616003957 Lumazine binding domain; Region: Lum_binding; pfam00677 652616003958 Lumazine binding domain; Region: Lum_binding; pfam00677 652616003959 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 652616003960 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 652616003961 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 652616003962 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 652616003963 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 652616003964 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 652616003965 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 652616003966 dimerization interface [polypeptide binding]; other site 652616003967 active site 652616003968 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 652616003969 homopentamer interface [polypeptide binding]; other site 652616003970 active site 652616003971 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 652616003972 PknH-like extracellular domain; Region: PknH_C; pfam14032 652616003973 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 652616003974 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 652616003975 putative sugar binding sites [chemical binding]; other site 652616003976 Q-X-W motif; other site 652616003977 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 652616003978 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 652616003979 GIY-YIG motif/motif A; other site 652616003980 active site 652616003981 catalytic site [active] 652616003982 putative DNA binding site [nucleotide binding]; other site 652616003983 metal binding site [ion binding]; metal-binding site 652616003984 UvrB/uvrC motif; Region: UVR; pfam02151 652616003985 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 652616003986 Helix-hairpin-helix motif; Region: HHH; pfam00633 652616003987 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 652616003988 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 652616003989 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 652616003990 phosphate binding site [ion binding]; other site 652616003991 putative substrate binding pocket [chemical binding]; other site 652616003992 dimer interface [polypeptide binding]; other site 652616003993 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 652616003994 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 652616003995 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 652616003996 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 652616003997 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 652616003998 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 652616003999 acyl-CoA synthetase; Provisional; Region: PRK13382 652616004000 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 652616004001 acyl-activating enzyme (AAE) consensus motif; other site 652616004002 putative AMP binding site [chemical binding]; other site 652616004003 putative active site [active] 652616004004 putative CoA binding site [chemical binding]; other site 652616004005 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 652616004006 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 652616004007 putative acyl-acceptor binding pocket; other site 652616004008 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 652616004009 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 652616004010 PE family; Region: PE; pfam00934 652616004011 PE-PPE domain; Region: PE-PPE; pfam08237 652616004012 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 652616004013 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 652616004014 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 652616004015 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 652616004016 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 652616004017 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 652616004018 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 652616004019 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 652616004020 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 652616004021 Phosphoglycerate kinase; Region: PGK; pfam00162 652616004022 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 652616004023 substrate binding site [chemical binding]; other site 652616004024 hinge regions; other site 652616004025 ADP binding site [chemical binding]; other site 652616004026 catalytic site [active] 652616004027 triosephosphate isomerase; Provisional; Region: PRK14567 652616004028 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 652616004029 substrate binding site [chemical binding]; other site 652616004030 dimer interface [polypeptide binding]; other site 652616004031 catalytic triad [active] 652616004032 SnoaL-like domain; Region: SnoaL_2; pfam12680 652616004033 Preprotein translocase SecG subunit; Region: SecG; cl09123 652616004034 PE family; Region: PE; pfam00934 652616004035 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 652616004036 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 652616004037 molybdopterin cofactor binding site [chemical binding]; other site 652616004038 substrate binding site [chemical binding]; other site 652616004039 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 652616004040 molybdopterin cofactor binding site; other site 652616004041 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 652616004042 hydrophobic ligand binding site; other site 652616004043 Proteins of 100 residues with WXG; Region: WXG100; cl02005 652616004044 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 652616004045 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 652616004046 putative active site [active] 652616004047 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 652616004048 Glucose-6-P dehydrogenase subunit [Carbohydrate transport and metabolism]; Region: COG3429 652616004049 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 652616004050 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 652616004051 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 652616004052 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 652616004053 putative active site [active] 652616004054 transaldolase; Provisional; Region: PRK03903 652616004055 catalytic residue [active] 652616004056 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 652616004057 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 652616004058 TPP-binding site [chemical binding]; other site 652616004059 dimer interface [polypeptide binding]; other site 652616004060 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 652616004061 PYR/PP interface [polypeptide binding]; other site 652616004062 dimer interface [polypeptide binding]; other site 652616004063 TPP binding site [chemical binding]; other site 652616004064 PE family; Region: PE; pfam00934 652616004065 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 652616004066 UbiA prenyltransferase family; Region: UbiA; pfam01040 652616004067 PE family; Region: PE; pfam00934 652616004068 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 652616004069 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 652616004070 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 652616004071 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 652616004072 NADP binding site [chemical binding]; other site 652616004073 dimer interface [polypeptide binding]; other site 652616004074 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 652616004075 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 652616004076 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 652616004077 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 652616004078 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 652616004079 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 652616004080 Walker A/P-loop; other site 652616004081 ATP binding site [chemical binding]; other site 652616004082 Q-loop/lid; other site 652616004083 ABC transporter signature motif; other site 652616004084 Walker B; other site 652616004085 D-loop; other site 652616004086 H-loop/switch region; other site 652616004087 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 652616004088 iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702 652616004089 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 652616004090 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 652616004091 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 652616004092 protein-splicing catalytic site; other site 652616004093 thioester formation/cholesterol transfer; other site 652616004094 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 652616004095 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 652616004096 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 652616004097 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 652616004098 FeS assembly protein SufD; Region: sufD; TIGR01981 652616004099 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 652616004100 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 652616004101 Walker A/P-loop; other site 652616004102 ATP binding site [chemical binding]; other site 652616004103 Q-loop/lid; other site 652616004104 ABC transporter signature motif; other site 652616004105 Walker B; other site 652616004106 D-loop; other site 652616004107 H-loop/switch region; other site 652616004108 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 652616004109 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 652616004110 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 652616004111 catalytic residue [active] 652616004112 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 652616004113 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 652616004114 trimerization site [polypeptide binding]; other site 652616004115 active site 652616004116 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 652616004117 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 652616004118 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 652616004119 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 652616004120 active site 652616004121 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 652616004122 PE family; Region: PE; pfam00934 652616004123 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 652616004124 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 652616004125 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 652616004126 catalytic residues [active] 652616004127 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 652616004128 catalytic residues [active] 652616004129 enoyl-CoA hydratase; Provisional; Region: PRK05864 652616004130 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 652616004131 substrate binding site [chemical binding]; other site 652616004132 oxyanion hole (OAH) forming residues; other site 652616004133 trimer interface [polypeptide binding]; other site 652616004134 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 652616004135 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 652616004136 Walker A/P-loop; other site 652616004137 ATP binding site [chemical binding]; other site 652616004138 Q-loop/lid; other site 652616004139 ABC transporter signature motif; other site 652616004140 Walker B; other site 652616004141 D-loop; other site 652616004142 H-loop/switch region; other site 652616004143 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 652616004144 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 652616004145 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 652616004146 aconitate hydratase; Validated; Region: PRK09277 652616004147 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 652616004148 substrate binding site [chemical binding]; other site 652616004149 ligand binding site [chemical binding]; other site 652616004150 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 652616004151 substrate binding site [chemical binding]; other site 652616004152 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 652616004153 NlpC/P60 family; Region: NLPC_P60; pfam00877 652616004154 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 652616004155 NlpC/P60 family; Region: NLPC_P60; pfam00877 652616004156 MoxR-like ATPases [General function prediction only]; Region: COG0714 652616004157 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 652616004158 Walker A motif; other site 652616004159 ATP binding site [chemical binding]; other site 652616004160 Walker B motif; other site 652616004161 arginine finger; other site 652616004162 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 652616004163 Protein of unknown function DUF58; Region: DUF58; pfam01882 652616004164 hypothetical protein; Provisional; Region: PRK13685 652616004165 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 652616004166 metal ion-dependent adhesion site (MIDAS); other site 652616004167 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 652616004168 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 652616004169 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 652616004170 NAD(P) binding site [chemical binding]; other site 652616004171 homotetramer interface [polypeptide binding]; other site 652616004172 homodimer interface [polypeptide binding]; other site 652616004173 active site 652616004174 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 652616004175 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 652616004176 NAD binding site [chemical binding]; other site 652616004177 homotetramer interface [polypeptide binding]; other site 652616004178 homodimer interface [polypeptide binding]; other site 652616004179 substrate binding site [chemical binding]; other site 652616004180 active site 652616004181 ferrochelatase; Reviewed; Region: hemH; PRK00035 652616004182 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 652616004183 C-terminal domain interface [polypeptide binding]; other site 652616004184 active site 652616004185 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 652616004186 active site 652616004187 N-terminal domain interface [polypeptide binding]; other site 652616004188 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 652616004189 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 652616004190 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 652616004191 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 652616004192 Uncharacterized conserved protein [Function unknown]; Region: COG0398 652616004193 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 652616004194 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 652616004195 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 652616004196 heterodimer interface [polypeptide binding]; other site 652616004197 substrate interaction site [chemical binding]; other site 652616004198 Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding) [Lipid metabolism]; Region: Sbm; COG2185 652616004199 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 652616004200 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 652616004201 active site 652616004202 substrate binding site [chemical binding]; other site 652616004203 coenzyme B12 binding site [chemical binding]; other site 652616004204 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 652616004205 B12 binding site [chemical binding]; other site 652616004206 cobalt ligand [ion binding]; other site 652616004207 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 652616004208 membrane ATPase/protein kinase; Provisional; Region: PRK09435 652616004209 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 652616004210 Walker A; other site 652616004211 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 652616004212 Beta-lactamase; Region: Beta-lactamase; pfam00144 652616004213 Methyltransferase domain; Region: Methyltransf_31; pfam13847 652616004214 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 652616004215 S-adenosylmethionine binding site [chemical binding]; other site 652616004216 Uncharacterized conserved protein [Function unknown]; Region: COG3360 652616004217 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 652616004218 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 652616004219 Putative Catalytic site; other site 652616004220 DXD motif; other site 652616004221 Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5285 652616004222 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 652616004223 active site 652616004224 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 652616004225 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 652616004226 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 652616004227 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 652616004228 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 652616004229 catalytic residue [active] 652616004230 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 652616004231 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 652616004232 putative trimer interface [polypeptide binding]; other site 652616004233 putative CoA binding site [chemical binding]; other site 652616004234 WbqC-like protein family; Region: WbqC; pfam08889 652616004235 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 652616004236 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 652616004237 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 652616004238 Methyltransferase domain; Region: Methyltransf_23; pfam13489 652616004239 Methyltransferase domain; Region: Methyltransf_12; pfam08242 652616004240 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 652616004241 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 652616004242 NADP-binding site; other site 652616004243 homotetramer interface [polypeptide binding]; other site 652616004244 substrate binding site [chemical binding]; other site 652616004245 homodimer interface [polypeptide binding]; other site 652616004246 active site 652616004247 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 652616004248 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 652616004249 NADP binding site [chemical binding]; other site 652616004250 active site 652616004251 putative substrate binding site [chemical binding]; other site 652616004252 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 652616004253 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 652616004254 metal-binding site 652616004255 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 652616004256 S-adenosylmethionine binding site [chemical binding]; other site 652616004257 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 652616004258 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 652616004259 active site 652616004260 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 652616004261 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 652616004262 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 652616004263 active site 652616004264 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 652616004265 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 652616004266 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 652616004267 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 652616004268 active site 652616004269 acyl-CoA synthetase; Validated; Region: PRK05850 652616004270 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 652616004271 acyl-activating enzyme (AAE) consensus motif; other site 652616004272 active site 652616004273 Transport protein; Region: actII; TIGR00833 652616004274 Methyltransferase domain; Region: Methyltransf_23; pfam13489 652616004275 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 652616004276 S-adenosylmethionine binding site [chemical binding]; other site 652616004277 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 652616004278 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 652616004279 homodimer interface [polypeptide binding]; other site 652616004280 active site 652616004281 TDP-binding site; other site 652616004282 acceptor substrate-binding pocket; other site 652616004283 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 652616004284 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 652616004285 Probable Catalytic site; other site 652616004286 metal-binding site 652616004287 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 652616004288 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 652616004289 homodimer interface [polypeptide binding]; other site 652616004290 active site 652616004291 TDP-binding site; other site 652616004292 acceptor substrate-binding pocket; other site 652616004293 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 652616004294 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 652616004295 active site 652616004296 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 652616004297 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 652616004298 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 652616004299 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 652616004300 Enoylreductase; Region: PKS_ER; smart00829 652616004301 NAD(P) binding site [chemical binding]; other site 652616004302 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 652616004303 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 652616004304 putative NADP binding site [chemical binding]; other site 652616004305 active site 652616004306 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 652616004307 acyl-CoA synthetase; Validated; Region: PRK05850 652616004308 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 652616004309 acyl-activating enzyme (AAE) consensus motif; other site 652616004310 active site 652616004311 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 652616004312 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 652616004313 NAD(P) binding site [chemical binding]; other site 652616004314 Uncharacterized conserved protein [Function unknown]; Region: COG2128 652616004315 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 652616004316 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 652616004317 CoenzymeA binding site [chemical binding]; other site 652616004318 subunit interaction site [polypeptide binding]; other site 652616004319 PHB binding site; other site 652616004320 Nitronate monooxygenase; Region: NMO; pfam03060 652616004321 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 652616004322 FMN binding site [chemical binding]; other site 652616004323 substrate binding site [chemical binding]; other site 652616004324 putative catalytic residue [active] 652616004325 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 652616004326 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 652616004327 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 652616004328 HIGH motif; other site 652616004329 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 652616004330 active site 652616004331 KMSKS motif; other site 652616004332 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 652616004333 tRNA binding surface [nucleotide binding]; other site 652616004334 anticodon binding site; other site 652616004335 DNA polymerase IV; Provisional; Region: PRK03348 652616004336 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 652616004337 active site 652616004338 DNA binding site [nucleotide binding] 652616004339 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 652616004340 active site 652616004341 homodimer interface [polypeptide binding]; other site 652616004342 homotetramer interface [polypeptide binding]; other site 652616004343 lipoprotein signal peptidase; Provisional; Region: PRK14764 652616004344 lipoprotein signal peptidase; Provisional; Region: PRK14787 652616004345 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 652616004346 active site 652616004347 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 652616004348 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 652616004349 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 652616004350 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 652616004351 apolar tunnel; other site 652616004352 heme binding site [chemical binding]; other site 652616004353 dimerization interface [polypeptide binding]; other site 652616004354 short chain dehydrogenase; Provisional; Region: PRK05866 652616004355 classical (c) SDRs; Region: SDR_c; cd05233 652616004356 NAD(P) binding site [chemical binding]; other site 652616004357 active site 652616004358 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 652616004359 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 652616004360 NAD(P) binding site [chemical binding]; other site 652616004361 active site 652616004362 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 652616004363 hydrophobic ligand binding site; other site 652616004364 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 652616004365 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 652616004366 active site 652616004367 PHP Thumb interface [polypeptide binding]; other site 652616004368 metal binding site [ion binding]; metal-binding site 652616004369 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 652616004370 generic binding surface II; other site 652616004371 generic binding surface I; other site 652616004372 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616004373 PPE family; Region: PPE; pfam00823 652616004374 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 652616004375 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 652616004376 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 652616004377 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 652616004378 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 652616004379 acyl-activating enzyme (AAE) consensus motif; other site 652616004380 putative AMP binding site [chemical binding]; other site 652616004381 putative active site [active] 652616004382 putative CoA binding site [chemical binding]; other site 652616004383 glycerol-3-phosphate acyltransferase; Reviewed; Region: PRK11915 652616004384 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 652616004385 putative acyl-acceptor binding pocket; other site 652616004386 fumarate reductase, flavoprotein subunit; Region: fum_red_Fp; TIGR01176 652616004387 L-aspartate oxidase; Provisional; Region: PRK06175 652616004388 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 652616004389 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 652616004390 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 652616004391 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 652616004392 D-subunit interface [polypeptide binding]; other site 652616004393 Iron-sulfur protein interface; other site 652616004394 proximal quinone binding site [chemical binding]; other site 652616004395 distal quinone binding site [chemical binding]; other site 652616004396 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 652616004397 Iron-sulfur protein interface; other site 652616004398 proximal quinone binding site [chemical binding]; other site 652616004399 C-subunit interface; other site 652616004400 distal quinone binding site; other site 652616004401 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 652616004402 MMPL family; Region: MMPL; pfam03176 652616004403 Domain of unknown function (DUF385); Region: DUF385; pfam04075 652616004404 threonine dehydratase; Validated; Region: PRK08639 652616004405 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 652616004406 tetramer interface [polypeptide binding]; other site 652616004407 pyridoxal 5'-phosphate binding site [chemical binding]; other site 652616004408 catalytic residue [active] 652616004409 C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585 652616004410 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 652616004411 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 652616004412 putative active site [active] 652616004413 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 652616004414 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 652616004415 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 652616004416 catalytic site [active] 652616004417 active site 652616004418 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 652616004419 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 652616004420 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 652616004421 active site 652616004422 catalytic site [active] 652616004423 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 652616004424 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 652616004425 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 652616004426 active site 652616004427 catalytic site [active] 652616004428 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 652616004429 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 652616004430 NlpC/P60 family; Region: NLPC_P60; pfam00877 652616004431 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 652616004432 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 652616004433 inhibitor-cofactor binding pocket; inhibition site 652616004434 pyridoxal 5'-phosphate binding site [chemical binding]; other site 652616004435 catalytic residue [active] 652616004436 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 652616004437 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 652616004438 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 652616004439 catalytic residue [active] 652616004440 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 652616004441 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 652616004442 Domain of unknown function (DUF222); Region: DUF222; pfam02720 652616004443 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 652616004444 active site 652616004445 biotin synthase; Validated; Region: PRK06256 652616004446 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 652616004447 FeS/SAM binding site; other site 652616004448 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 652616004449 Protein of unknown function (DUF2567); Region: DUF2567; pfam10821 652616004450 Secretory lipase; Region: LIP; pfam03583 652616004451 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 652616004452 nudix motif; other site 652616004453 quinolinate synthetase; Provisional; Region: PRK09375 652616004454 L-aspartate oxidase; Provisional; Region: PRK07804 652616004455 L-aspartate oxidase; Provisional; Region: PRK06175 652616004456 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 652616004457 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 652616004458 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 652616004459 dimerization interface [polypeptide binding]; other site 652616004460 active site 652616004461 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 652616004462 S-adenosylmethionine binding site [chemical binding]; other site 652616004463 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 652616004464 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 652616004465 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 652616004466 NAD binding site [chemical binding]; other site 652616004467 dimerization interface [polypeptide binding]; other site 652616004468 product binding site; other site 652616004469 substrate binding site [chemical binding]; other site 652616004470 zinc binding site [ion binding]; other site 652616004471 catalytic residues [active] 652616004472 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 652616004473 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 652616004474 pyridoxal 5'-phosphate binding site [chemical binding]; other site 652616004475 homodimer interface [polypeptide binding]; other site 652616004476 catalytic residue [active] 652616004477 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 652616004478 4-fold oligomerization interface [polypeptide binding]; other site 652616004479 putative active site pocket [active] 652616004480 metal binding residues [ion binding]; metal-binding site 652616004481 3-fold/trimer interface [polypeptide binding]; other site 652616004482 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 652616004483 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 652616004484 putative active site [active] 652616004485 oxyanion strand; other site 652616004486 catalytic triad [active] 652616004487 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 652616004488 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 652616004489 catalytic residues [active] 652616004490 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 652616004491 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 652616004492 active site 652616004493 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 652616004494 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 652616004495 substrate binding site [chemical binding]; other site 652616004496 glutamase interaction surface [polypeptide binding]; other site 652616004497 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 652616004498 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 652616004499 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 652616004500 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 652616004501 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 652616004502 catalytic triad [active] 652616004503 anthranilate synthase component I; Provisional; Region: PRK13571 652616004504 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 652616004505 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 652616004506 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 652616004507 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 652616004508 active site 652616004509 ribulose/triose binding site [chemical binding]; other site 652616004510 phosphate binding site [ion binding]; other site 652616004511 substrate (anthranilate) binding pocket [chemical binding]; other site 652616004512 product (indole) binding pocket [chemical binding]; other site 652616004513 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 652616004514 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 652616004515 pyridoxal 5'-phosphate binding site [chemical binding]; other site 652616004516 catalytic residue [active] 652616004517 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 652616004518 substrate binding site [chemical binding]; other site 652616004519 active site 652616004520 catalytic residues [active] 652616004521 heterodimer interface [polypeptide binding]; other site 652616004522 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108 652616004523 Prolipoprotein diacylglyceryltransferase [Cell envelope biogenesis, outer membrane]; Region: Lgt; COG0682 652616004524 TM2 domain; Region: TM2; pfam05154 652616004525 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 652616004526 pyruvate kinase; Provisional; Region: PRK06247 652616004527 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 652616004528 active site 652616004529 domain interfaces; other site 652616004530 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 652616004531 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 652616004532 active site 652616004533 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 652616004534 catalytic triad [active] 652616004535 dimer interface [polypeptide binding]; other site 652616004536 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 652616004537 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 652616004538 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 652616004539 Walker A/P-loop; other site 652616004540 Walker A/P-loop; other site 652616004541 ATP binding site [chemical binding]; other site 652616004542 ATP binding site [chemical binding]; other site 652616004543 Q-loop/lid; other site 652616004544 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 652616004545 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 652616004546 Walker A/P-loop; other site 652616004547 ATP binding site [chemical binding]; other site 652616004548 Q-loop/lid; other site 652616004549 ABC transporter signature motif; other site 652616004550 Walker B; other site 652616004551 D-loop; other site 652616004552 H-loop/switch region; other site 652616004553 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 652616004554 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 652616004555 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 652616004556 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 652616004557 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 652616004558 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 652616004559 cyclase homology domain; Region: CHD; cd07302 652616004560 nucleotidyl binding site; other site 652616004561 metal binding site [ion binding]; metal-binding site 652616004562 dimer interface [polypeptide binding]; other site 652616004563 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 652616004564 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 652616004565 active site 652616004566 phosphorylation site [posttranslational modification] 652616004567 intermolecular recognition site; other site 652616004568 dimerization interface [polypeptide binding]; other site 652616004569 ANTAR domain; Region: ANTAR; pfam03861 652616004570 lipid-transfer protein; Provisional; Region: PRK06059 652616004571 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 652616004572 active site 652616004573 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 652616004574 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 652616004575 DUF35 OB-fold domain; Region: DUF35; pfam01796 652616004576 DNA polymerase I; Provisional; Region: PRK05755 652616004577 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 652616004578 active site 652616004579 metal binding site 1 [ion binding]; metal-binding site 652616004580 putative 5' ssDNA interaction site; other site 652616004581 metal binding site 3; metal-binding site 652616004582 metal binding site 2 [ion binding]; metal-binding site 652616004583 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 652616004584 putative DNA binding site [nucleotide binding]; other site 652616004585 putative metal binding site [ion binding]; other site 652616004586 3'-5' exonuclease; Region: 35EXOc; smart00474 652616004587 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 652616004588 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 652616004589 active site 652616004590 DNA binding site [nucleotide binding] 652616004591 catalytic site [active] 652616004592 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 652616004593 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 652616004594 RNA binding site [nucleotide binding]; other site 652616004595 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 652616004596 RNA binding site [nucleotide binding]; other site 652616004597 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 652616004598 RNA binding site [nucleotide binding]; other site 652616004599 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 652616004600 RNA binding site [nucleotide binding]; other site 652616004601 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 652616004602 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 652616004603 CoA-binding site [chemical binding]; other site 652616004604 ATP-binding [chemical binding]; other site 652616004605 Uncharacterized conserved protein [Function unknown]; Region: GrpB; COG2320 652616004606 Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306 652616004607 excinuclease ABC subunit B; Provisional; Region: PRK05298 652616004608 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 652616004609 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 652616004610 nucleotide binding region [chemical binding]; other site 652616004611 ATP-binding site [chemical binding]; other site 652616004612 Ultra-violet resistance protein B; Region: UvrB; pfam12344 652616004613 UvrB/uvrC motif; Region: UVR; pfam02151 652616004614 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 652616004615 Major Facilitator Superfamily; Region: MFS_1; pfam07690 652616004616 putative substrate translocation pore; other site 652616004617 Predicted membrane protein [Function unknown]; Region: COG5305 652616004618 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 652616004619 Ligand Binding Site [chemical binding]; other site 652616004620 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 652616004621 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 652616004622 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 652616004623 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 652616004624 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 652616004625 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 652616004626 Predicted esterase [General function prediction only]; Region: COG0627 652616004627 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 652616004628 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 652616004629 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 652616004630 dimer interface [polypeptide binding]; other site 652616004631 putative anticodon binding site; other site 652616004632 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 652616004633 motif 1; other site 652616004634 dimer interface [polypeptide binding]; other site 652616004635 active site 652616004636 motif 2; other site 652616004637 motif 3; other site 652616004638 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 652616004639 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 652616004640 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 652616004641 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 652616004642 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 652616004643 23S rRNA binding site [nucleotide binding]; other site 652616004644 L21 binding site [polypeptide binding]; other site 652616004645 L13 binding site [polypeptide binding]; other site 652616004646 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 652616004647 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 652616004648 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 652616004649 PE family; Region: PE; pfam00934 652616004650 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 652616004651 cyclase homology domain; Region: CHD; cd07302 652616004652 nucleotidyl binding site; other site 652616004653 metal binding site [ion binding]; metal-binding site 652616004654 dimer interface [polypeptide binding]; other site 652616004655 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 652616004656 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 652616004657 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 652616004658 dimer interface [polypeptide binding]; other site 652616004659 motif 1; other site 652616004660 active site 652616004661 motif 2; other site 652616004662 motif 3; other site 652616004663 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 652616004664 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 652616004665 putative tRNA-binding site [nucleotide binding]; other site 652616004666 B3/4 domain; Region: B3_4; pfam03483 652616004667 tRNA synthetase B5 domain; Region: B5; smart00874 652616004668 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 652616004669 dimer interface [polypeptide binding]; other site 652616004670 motif 1; other site 652616004671 motif 3; other site 652616004672 motif 2; other site 652616004673 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 652616004674 PE family; Region: PE; pfam00934 652616004675 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 652616004676 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 652616004677 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 652616004678 heterotetramer interface [polypeptide binding]; other site 652616004679 active site pocket [active] 652616004680 cleavage site 652616004681 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 652616004682 feedback inhibition sensing region; other site 652616004683 homohexameric interface [polypeptide binding]; other site 652616004684 nucleotide binding site [chemical binding]; other site 652616004685 N-acetyl-L-glutamate binding site [chemical binding]; other site 652616004686 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 652616004687 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 652616004688 inhibitor-cofactor binding pocket; inhibition site 652616004689 pyridoxal 5'-phosphate binding site [chemical binding]; other site 652616004690 catalytic residue [active] 652616004691 ornithine carbamoyltransferase; Provisional; Region: PRK00779 652616004692 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 652616004693 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 652616004694 arginine repressor; Provisional; Region: PRK03341 652616004695 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 652616004696 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 652616004697 argininosuccinate synthase; Provisional; Region: PRK13820 652616004698 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 652616004699 ANP binding site [chemical binding]; other site 652616004700 Substrate Binding Site II [chemical binding]; other site 652616004701 Substrate Binding Site I [chemical binding]; other site 652616004702 argininosuccinate lyase; Provisional; Region: PRK00855 652616004703 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 652616004704 active sites [active] 652616004705 tetramer interface [polypeptide binding]; other site 652616004706 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 652616004707 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 652616004708 malonyl-CoA binding site [chemical binding]; other site 652616004709 dimer interface [polypeptide binding]; other site 652616004710 active site 652616004711 product binding site; other site 652616004712 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 652616004713 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 652616004714 active site 652616004715 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 652616004716 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 652616004717 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 652616004718 Enoylreductase; Region: PKS_ER; smart00829 652616004719 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 652616004720 NAD(P) binding site [chemical binding]; other site 652616004721 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 652616004722 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 652616004723 putative NADP binding site [chemical binding]; other site 652616004724 active site 652616004725 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 652616004726 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 652616004727 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 652616004728 active site 652616004729 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 652616004730 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 652616004731 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 652616004732 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 652616004733 Enoylreductase; Region: PKS_ER; smart00829 652616004734 NAD(P) binding site [chemical binding]; other site 652616004735 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 652616004736 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 652616004737 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 652616004738 putative NADP binding site [chemical binding]; other site 652616004739 active site 652616004740 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 652616004741 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 652616004742 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 652616004743 active site 652616004744 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 652616004745 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 652616004746 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 652616004747 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 652616004748 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 652616004749 malonyl-CoA binding site [chemical binding]; other site 652616004750 dimer interface [polypeptide binding]; other site 652616004751 active site 652616004752 product binding site; other site 652616004753 Cytochrome P450; Region: p450; cl12078 652616004754 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 652616004755 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 652616004756 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 652616004757 ABC transporter; Region: ABC_tran_2; pfam12848 652616004758 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 652616004759 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 652616004760 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 652616004761 putative substrate translocation pore; other site 652616004762 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 652616004763 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 652616004764 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 652616004765 dimerization interface [polypeptide binding]; other site 652616004766 putative DNA binding site [nucleotide binding]; other site 652616004767 putative Zn2+ binding site [ion binding]; other site 652616004768 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 652616004769 active site residue [active] 652616004770 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 652616004771 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 652616004772 ligand binding site [chemical binding]; other site 652616004773 flexible hinge region; other site 652616004774 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 652616004775 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 652616004776 putative catalytic residues [active] 652616004777 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 652616004778 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 652616004779 catalytic residues [active] 652616004780 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 652616004781 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 652616004782 active site 652616004783 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 652616004784 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 652616004785 substrate binding pocket [chemical binding]; other site 652616004786 membrane-bound complex binding site; other site 652616004787 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 652616004788 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 652616004789 FeS/SAM binding site; other site 652616004790 DivIVA protein; Region: DivIVA; pfam05103 652616004791 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 652616004792 acyl-CoA synthetase; Validated; Region: PRK07868 652616004793 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 652616004794 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 652616004795 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 652616004796 acyl-activating enzyme (AAE) consensus motif; other site 652616004797 AMP binding site [chemical binding]; other site 652616004798 active site 652616004799 CoA binding site [chemical binding]; other site 652616004800 Uncharacterized conserved protein [Function unknown]; Region: COG2835 652616004801 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 652616004802 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 652616004803 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 652616004804 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 652616004805 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 652616004806 Walker A/P-loop; other site 652616004807 ATP binding site [chemical binding]; other site 652616004808 Q-loop/lid; other site 652616004809 ABC transporter signature motif; other site 652616004810 Walker B; other site 652616004811 D-loop; other site 652616004812 H-loop/switch region; other site 652616004813 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 652616004814 active site 652616004815 DNA binding site [nucleotide binding] 652616004816 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 652616004817 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 652616004818 active site 652616004819 HIGH motif; other site 652616004820 dimer interface [polypeptide binding]; other site 652616004821 KMSKS motif; other site 652616004822 S4 RNA-binding domain; Region: S4; smart00363 652616004823 RNA binding surface [nucleotide binding]; other site 652616004824 Protein of unknown function (DUF732); Region: DUF732; pfam05305 652616004825 Tetratrico peptide repeat; Region: TPR_5; pfam12688 652616004826 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 652616004827 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 652616004828 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 652616004829 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 652616004830 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 652616004831 RNA binding surface [nucleotide binding]; other site 652616004832 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 652616004833 S-adenosylmethionine binding site [chemical binding]; other site 652616004834 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 652616004835 ATP-NAD kinase; Region: NAD_kinase; pfam01513 652616004836 DNA repair protein RecN; Region: recN; TIGR00634 652616004837 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 652616004838 Walker A/P-loop; other site 652616004839 ATP binding site [chemical binding]; other site 652616004840 Q-loop/lid; other site 652616004841 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 652616004842 ABC transporter signature motif; other site 652616004843 Walker B; other site 652616004844 D-loop; other site 652616004845 H-loop/switch region; other site 652616004846 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 652616004847 Thiamine pyrophosphokinase; Region: TPK; cl08415 652616004848 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 652616004849 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 652616004850 CTP synthetase; Validated; Region: pyrG; PRK05380 652616004851 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 652616004852 Catalytic site [active] 652616004853 active site 652616004854 UTP binding site [chemical binding]; other site 652616004855 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 652616004856 active site 652616004857 putative oxyanion hole; other site 652616004858 catalytic triad [active] 652616004859 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 652616004860 dimer interface [polypeptide binding]; other site 652616004861 ADP-ribose binding site [chemical binding]; other site 652616004862 active site 652616004863 nudix motif; other site 652616004864 metal binding site [ion binding]; metal-binding site 652616004865 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 652616004866 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 652616004867 active site 652616004868 DNA binding site [nucleotide binding] 652616004869 Int/Topo IB signature motif; other site 652616004870 Domain of unknown function (DUF222); Region: DUF222; pfam02720 652616004871 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 652616004872 active site 652616004873 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 652616004874 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 652616004875 S-adenosylmethionine binding site [chemical binding]; other site 652616004876 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 652616004877 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616004878 PPE family; Region: PPE; pfam00823 652616004879 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 652616004880 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616004881 PPE family; Region: PPE; pfam00823 652616004882 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 652616004883 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 652616004884 Sulfate transporter family; Region: Sulfate_transp; pfam00916 652616004885 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 652616004886 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 652616004887 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 652616004888 P-loop; other site 652616004889 Magnesium ion binding site [ion binding]; other site 652616004890 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 652616004891 Magnesium ion binding site [ion binding]; other site 652616004892 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 652616004893 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 652616004894 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 652616004895 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 652616004896 RNA binding surface [nucleotide binding]; other site 652616004897 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 652616004898 active site 652616004899 cytidylate kinase; Provisional; Region: cmk; PRK00023 652616004900 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 652616004901 CMP-binding site; other site 652616004902 The sites determining sugar specificity; other site 652616004903 GTP-binding protein Der; Reviewed; Region: PRK03003 652616004904 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 652616004905 GTP/Mg2+ binding site [chemical binding]; other site 652616004906 Switch I region; other site 652616004907 G2 box; other site 652616004908 Switch II region; other site 652616004909 G3 box; other site 652616004910 G4 box; other site 652616004911 G5 box; other site 652616004912 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 652616004913 G1 box; other site 652616004914 GTP/Mg2+ binding site [chemical binding]; other site 652616004915 Switch I region; other site 652616004916 G2 box; other site 652616004917 G3 box; other site 652616004918 Switch II region; other site 652616004919 G4 box; other site 652616004920 G5 box; other site 652616004921 short chain dehydrogenase; Provisional; Region: PRK06841 652616004922 classical (c) SDRs; Region: SDR_c; cd05233 652616004923 NAD(P) binding site [chemical binding]; other site 652616004924 active site 652616004925 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 652616004926 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 652616004927 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 652616004928 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 652616004929 Cupin domain; Region: Cupin_2; pfam07883 652616004930 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 652616004931 Transcriptional regulator [Transcription]; Region: IclR; COG1414 652616004932 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 652616004933 putative switch regulator; other site 652616004934 non-specific DNA interactions [nucleotide binding]; other site 652616004935 DNA binding site [nucleotide binding] 652616004936 sequence specific DNA binding site [nucleotide binding]; other site 652616004937 putative cAMP binding site [chemical binding]; other site 652616004938 Bacterial transcriptional regulator; Region: IclR; pfam01614 652616004939 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 652616004940 putative active site [active] 652616004941 homotetrameric interface [polypeptide binding]; other site 652616004942 metal binding site [ion binding]; metal-binding site 652616004943 biotin carboxylase-like protein; Validated; Region: PRK06524 652616004944 ATP-grasp domain; Region: ATP-grasp_4; cl17255 652616004945 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 652616004946 Beta-lactamase; Region: Beta-lactamase; pfam00144 652616004947 putative transposase OrfB; Reviewed; Region: PHA02517 652616004948 HTH-like domain; Region: HTH_21; pfam13276 652616004949 Integrase core domain; Region: rve; pfam00665 652616004950 Integrase core domain; Region: rve_3; pfam13683 652616004951 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 652616004952 Transposase; Region: HTH_Tnp_1; cl17663 652616004953 Predicted transcriptional regulators [Transcription]; Region: COG1733 652616004954 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 652616004955 dimerization interface [polypeptide binding]; other site 652616004956 putative DNA binding site [nucleotide binding]; other site 652616004957 putative Zn2+ binding site [ion binding]; other site 652616004958 Predicted transcriptional regulators [Transcription]; Region: COG1733 652616004959 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 652616004960 FAD binding domain; Region: FAD_binding_4; pfam01565 652616004961 Berberine and berberine like; Region: BBE; pfam08031 652616004962 TIGR03086 family protein; Region: TIGR03086 652616004963 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 652616004964 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 652616004965 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 652616004966 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 652616004967 Beta-lactamase; Region: Beta-lactamase; pfam00144 652616004968 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 652616004969 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 652616004970 NAD(P) binding site [chemical binding]; other site 652616004971 catalytic residues [active] 652616004972 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 652616004973 putative catalytic residue [active] 652616004974 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 652616004975 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 652616004976 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 652616004977 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 652616004978 gating phenylalanine in ion channel; other site 652616004979 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 652616004980 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 652616004981 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 652616004982 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 652616004983 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 652616004984 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 652616004985 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 652616004986 putative substrate translocation pore; other site 652616004987 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 652616004988 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 652616004989 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 652616004990 Sulfate transporter family; Region: Sulfate_transp; pfam00916 652616004991 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 652616004992 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 652616004993 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3742 652616004994 putative active site [active] 652616004995 Protein tyrosine kinase; Region: Pkinase_Tyr; pfam07714 652616004996 Catalytic domain of Protein Kinases; Region: PKc; cd00180 652616004997 active site 652616004998 ATP binding site [chemical binding]; other site 652616004999 substrate binding site [chemical binding]; other site 652616005000 activation loop (A-loop); other site 652616005001 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 652616005002 Thioredoxin; Region: Thioredoxin_4; cl17273 652616005003 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 652616005004 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 652616005005 active site 652616005006 metal binding site [ion binding]; metal-binding site 652616005007 nudix motif; other site 652616005008 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 652616005009 Catalytic domain of Protein Kinases; Region: PKc; cd00180 652616005010 active site 652616005011 ATP binding site [chemical binding]; other site 652616005012 substrate binding site [chemical binding]; other site 652616005013 activation loop (A-loop); other site 652616005014 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 652616005015 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 652616005016 phosphopeptide binding site; other site 652616005017 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 652616005018 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 652616005019 phosphopeptide binding site; other site 652616005020 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 652616005021 The Eye Pigment Precursor Transporter (EPP) Family protein; Region: 3a01204; TIGR00955 652616005022 Walker A/P-loop; other site 652616005023 ATP binding site [chemical binding]; other site 652616005024 Q-loop/lid; other site 652616005025 ABC transporter signature motif; other site 652616005026 Walker B; other site 652616005027 D-loop; other site 652616005028 H-loop/switch region; other site 652616005029 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 652616005030 acyl-CoA synthetase; Provisional; Region: PRK13388 652616005031 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 652616005032 acyl-activating enzyme (AAE) consensus motif; other site 652616005033 AMP binding site [chemical binding]; other site 652616005034 active site 652616005035 CoA binding site [chemical binding]; other site 652616005036 hypothetical protein; Provisional; Region: PRK06185 652616005037 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 652616005038 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 652616005039 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 652616005040 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616005041 PPE family; Region: PPE; pfam00823 652616005042 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 652616005043 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 652616005044 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 652616005045 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 652616005046 Transposase; Region: HTH_Tnp_1; cl17663 652616005047 putative transposase OrfB; Reviewed; Region: PHA02517 652616005048 HTH-like domain; Region: HTH_21; pfam13276 652616005049 Integrase core domain; Region: rve; pfam00665 652616005050 Integrase core domain; Region: rve_3; pfam13683 652616005051 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 652616005052 Phosphoesterase family; Region: Phosphoesterase; pfam04185 652616005053 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 652616005054 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 652616005055 sulfite oxidase; Provisional; Region: PLN00177 652616005056 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 652616005057 Moco binding site; other site 652616005058 metal coordination site [ion binding]; other site 652616005059 dimerization interface [polypeptide binding]; other site 652616005060 Transport protein; Region: actII; TIGR00833 652616005061 Cutinase; Region: Cutinase; pfam01083 652616005062 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 652616005063 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 652616005064 Uncharacterized conserved protein [Function unknown]; Region: COG0393 652616005065 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 652616005066 Domain of unknown function (DUF222); Region: DUF222; pfam02720 652616005067 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 652616005068 active site 652616005069 Integrase core domain; Region: rve; pfam00665 652616005070 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 652616005071 putative homotetramer interface [polypeptide binding]; other site 652616005072 putative homodimer interface [polypeptide binding]; other site 652616005073 putative allosteric switch controlling residues; other site 652616005074 putative metal binding site [ion binding]; other site 652616005075 putative homodimer-homodimer interface [polypeptide binding]; other site 652616005076 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 652616005077 PE family; Region: PE; pfam00934 652616005078 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 652616005079 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 652616005080 dimer interface [polypeptide binding]; other site 652616005081 active site 652616005082 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 652616005083 substrate binding site [chemical binding]; other site 652616005084 catalytic residue [active] 652616005085 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 652616005086 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 652616005087 metal binding site [ion binding]; metal-binding site 652616005088 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 652616005089 FAD binding domain; Region: FAD_binding_4; pfam01565 652616005090 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 652616005091 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 652616005092 Transcriptional regulator [Transcription]; Region: IclR; COG1414 652616005093 Bacterial transcriptional regulator; Region: IclR; pfam01614 652616005094 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 652616005095 FAD binding domain; Region: FAD_binding_4; pfam01565 652616005096 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 652616005097 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 652616005098 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 652616005099 Cytochrome P450; Region: p450; cl12078 652616005100 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 652616005101 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 652616005102 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 652616005103 Protein of unknown function (DUF690); Region: DUF690; pfam05108 652616005104 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 652616005105 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 652616005106 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 652616005107 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 652616005108 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 652616005109 Cytochrome P450; Region: p450; cl12078 652616005110 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 652616005111 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616005112 PPE family; Region: PPE; pfam00823 652616005113 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 652616005114 PE family; Region: PE; pfam00934 652616005115 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616005116 PPE family; Region: PPE; pfam00823 652616005117 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 652616005118 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616005119 PPE family; Region: PPE; pfam00823 652616005120 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 652616005121 PE family; Region: PE; pfam00934 652616005122 Proteins of 100 residues with WXG; Region: WXG100; cl02005 652616005123 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 652616005124 EspG family; Region: ESX-1_EspG; pfam14011 652616005125 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 652616005126 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 652616005127 catalytic residues [active] 652616005128 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 652616005129 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 652616005130 active site 652616005131 catalytic residues [active] 652616005132 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 652616005133 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 652616005134 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 652616005135 Walker A motif; other site 652616005136 ATP binding site [chemical binding]; other site 652616005137 Walker B motif; other site 652616005138 arginine finger; other site 652616005139 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616005140 PPE family; Region: PPE; pfam00823 652616005141 PE-PPE domain; Region: PE-PPE; pfam08237 652616005142 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616005143 PPE family; Region: PPE; pfam00823 652616005144 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616005145 PPE family; Region: PPE; pfam00823 652616005146 PE family; Region: PE; pfam00934 652616005147 Protein of unknown function (DUF732); Region: DUF732; pfam05305 652616005148 PE family; Region: PE; pfam00934 652616005149 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616005150 PPE family; Region: PPE; pfam00823 652616005151 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616005152 PPE family; Region: PPE; pfam00823 652616005153 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616005154 PPE family; Region: PPE; pfam00823 652616005155 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 652616005156 Protein of unknown function (DUF732); Region: DUF732; pfam05305 652616005157 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 652616005158 MgtC family; Region: MgtC; pfam02308 652616005159 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 652616005160 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 652616005161 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 652616005162 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 652616005163 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 652616005164 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 652616005165 hypothetical protein; Validated; Region: PRK07121 652616005166 ABC transporter transmembrane region 2; Region: ABC_membrane_2; pfam06472 652616005167 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 652616005168 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 652616005169 hypothetical protein; Provisional; Region: PRK05858 652616005170 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 652616005171 PYR/PP interface [polypeptide binding]; other site 652616005172 dimer interface [polypeptide binding]; other site 652616005173 TPP binding site [chemical binding]; other site 652616005174 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 652616005175 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 652616005176 TPP-binding site; other site 652616005177 dimer interface [polypeptide binding]; other site 652616005178 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 652616005179 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 652616005180 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 652616005181 nucleotide binding region [chemical binding]; other site 652616005182 ATP-binding site [chemical binding]; other site 652616005183 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 652616005184 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 652616005185 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 652616005186 Protein of unknown function (DUF1290); Region: DUF1290; cl01587 652616005187 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 652616005188 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 652616005189 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 652616005190 lipoyl attachment site [posttranslational modification]; other site 652616005191 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 652616005192 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 652616005193 phosphopeptide binding site; other site 652616005194 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 652616005195 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 652616005196 DNA binding residues [nucleotide binding] 652616005197 Bifunctional nuclease; Region: DNase-RNase; pfam02577 652616005198 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 652616005199 DNA binding residues [nucleotide binding] 652616005200 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 652616005201 putative dimer interface [polypeptide binding]; other site 652616005202 glycine dehydrogenase; Provisional; Region: PRK05367 652616005203 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 652616005204 pyridoxal 5'-phosphate binding site [chemical binding]; other site 652616005205 tetramer interface [polypeptide binding]; other site 652616005206 catalytic residue [active] 652616005207 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 652616005208 tetramer interface [polypeptide binding]; other site 652616005209 pyridoxal 5'-phosphate binding site [chemical binding]; other site 652616005210 catalytic residue [active] 652616005211 haloalkane dehalogenase; Provisional; Region: PRK03204 652616005212 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 652616005213 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 652616005214 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 652616005215 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 652616005216 metal ion-dependent adhesion site (MIDAS); other site 652616005217 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 652616005218 active site 652616005219 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 652616005220 putative active site [active] 652616005221 Domain of unknown function DUF21; Region: DUF21; pfam01595 652616005222 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 652616005223 FOG: CBS domain [General function prediction only]; Region: COG0517 652616005224 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 652616005225 Domain of unknown function DUF21; Region: DUF21; pfam01595 652616005226 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 652616005227 Transporter associated domain; Region: CorC_HlyC; smart01091 652616005228 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 652616005229 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 652616005230 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 652616005231 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 652616005232 active site 652616005233 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 652616005234 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 652616005235 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 652616005236 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 652616005237 Predicted transcriptional regulator [Transcription]; Region: COG3682 652616005238 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 652616005239 CoenzymeA binding site [chemical binding]; other site 652616005240 subunit interaction site [polypeptide binding]; other site 652616005241 PHB binding site; other site 652616005242 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 652616005243 alpha-gamma subunit interface [polypeptide binding]; other site 652616005244 beta-gamma subunit interface [polypeptide binding]; other site 652616005245 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 652616005246 gamma-beta subunit interface [polypeptide binding]; other site 652616005247 alpha-beta subunit interface [polypeptide binding]; other site 652616005248 urease subunit alpha; Reviewed; Region: ureC; PRK13206 652616005249 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 652616005250 subunit interactions [polypeptide binding]; other site 652616005251 active site 652616005252 flap region; other site 652616005253 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 652616005254 UreF; Region: UreF; pfam01730 652616005255 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 652616005256 UreD urease accessory protein; Region: UreD; cl00530 652616005257 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 652616005258 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 652616005259 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 652616005260 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 652616005261 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 652616005262 classical (c) SDRs; Region: SDR_c; cd05233 652616005263 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 652616005264 NAD(P) binding site [chemical binding]; other site 652616005265 active site 652616005266 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 652616005267 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 652616005268 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 652616005269 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 652616005270 dimer interface [polypeptide binding]; other site 652616005271 conserved gate region; other site 652616005272 putative PBP binding loops; other site 652616005273 ABC-ATPase subunit interface; other site 652616005274 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 652616005275 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 652616005276 Walker A/P-loop; other site 652616005277 ATP binding site [chemical binding]; other site 652616005278 Q-loop/lid; other site 652616005279 ABC transporter signature motif; other site 652616005280 Walker B; other site 652616005281 D-loop; other site 652616005282 H-loop/switch region; other site 652616005283 TOBE domain; Region: TOBE; pfam03459 652616005284 Fibronectin-attachment protein (FAP); Region: FAP; pfam07174 652616005285 Predicted membrane protein [Function unknown]; Region: COG2261 652616005286 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 652616005287 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 652616005288 putative NAD(P) binding site [chemical binding]; other site 652616005289 putative substrate binding site [chemical binding]; other site 652616005290 catalytic Zn binding site [ion binding]; other site 652616005291 structural Zn binding site [ion binding]; other site 652616005292 CAAX protease self-immunity; Region: Abi; pfam02517 652616005293 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 652616005294 MOSC domain; Region: MOSC; pfam03473 652616005295 short chain dehydrogenase; Provisional; Region: PRK07825 652616005296 classical (c) SDRs; Region: SDR_c; cd05233 652616005297 NAD(P) binding site [chemical binding]; other site 652616005298 active site 652616005299 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 652616005300 CoA-transferase family III; Region: CoA_transf_3; pfam02515 652616005301 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 652616005302 CoA-transferase family III; Region: CoA_transf_3; pfam02515 652616005303 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 652616005304 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 652616005305 active site 652616005306 hypothetical protein; Provisional; Region: PRK12320 652616005307 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 652616005308 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 652616005309 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 652616005310 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 652616005311 Domain of unknown function (DUF385); Region: DUF385; pfam04075 652616005312 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 652616005313 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 652616005314 active site 652616005315 substrate binding site [chemical binding]; other site 652616005316 FMN binding site [chemical binding]; other site 652616005317 putative catalytic residues [active] 652616005318 Protein of unknown function (DUF1810); Region: DUF1810; cl02370 652616005319 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 652616005320 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 652616005321 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 652616005322 heme binding site [chemical binding]; other site 652616005323 ferroxidase pore; other site 652616005324 ferroxidase diiron center [ion binding]; other site 652616005325 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 652616005326 Major Facilitator Superfamily; Region: MFS_1; pfam07690 652616005327 putative substrate translocation pore; other site 652616005328 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 652616005329 putative substrate translocation pore; other site 652616005330 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cl00333 652616005331 23S rRNA interface [nucleotide binding]; other site 652616005332 L3 interface [polypeptide binding]; other site 652616005333 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 652616005334 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 652616005335 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 652616005336 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 652616005337 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 652616005338 Cytochrome P450; Region: p450; cl12078 652616005339 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 652616005340 short chain dehydrogenase; Provisional; Region: PRK08267 652616005341 classical (c) SDR, subgroup 9; Region: SDR_c9; cd08931 652616005342 putative NAD(P) binding site [chemical binding]; other site 652616005343 active site 652616005344 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 652616005345 hydrophobic ligand binding site; other site 652616005346 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 652616005347 chorismate mutase; Provisional; Region: PRK09269 652616005348 chorismate mutase, putative; Region: CM_mono2; TIGR01806 652616005349 Putative esterase; Region: Esterase; pfam00756 652616005350 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 652616005351 Leucine carboxyl methyltransferase; Region: LCM; cl01306 652616005352 YceI-like domain; Region: YceI; cl01001 652616005353 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 652616005354 FMN binding site [chemical binding]; other site 652616005355 substrate binding site [chemical binding]; other site 652616005356 putative catalytic residue [active] 652616005357 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 2; Region: FDH_like_2; cd08284 652616005358 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 652616005359 catalytic Zn binding site [ion binding]; other site 652616005360 NAD(P) binding site [chemical binding]; other site 652616005361 structural Zn binding site [ion binding]; other site 652616005362 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 652616005363 dimerization interface [polypeptide binding]; other site 652616005364 putative tRNAtyr binding site [nucleotide binding]; other site 652616005365 putative active site [active] 652616005366 Domain of unknown function DUF77; Region: DUF77; pfam01910 652616005367 Macro domain, Unknown family 2. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_2; cd03330 652616005368 putative ADP-ribose binding site [chemical binding]; other site 652616005369 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 652616005370 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 652616005371 cyclase homology domain; Region: CHD; cd07302 652616005372 nucleotidyl binding site; other site 652616005373 metal binding site [ion binding]; metal-binding site 652616005374 dimer interface [polypeptide binding]; other site 652616005375 competence damage-inducible protein A; Provisional; Region: PRK00549 652616005376 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 652616005377 putative MPT binding site; other site 652616005378 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 652616005379 putative sialic acid transporter; Region: 2A0112; TIGR00891 652616005380 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 652616005381 putative substrate translocation pore; other site 652616005382 Predicted membrane protein [Function unknown]; Region: COG1950 652616005383 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 652616005384 anti sigma factor interaction site; other site 652616005385 regulatory phosphorylation site [posttranslational modification]; other site 652616005386 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 652616005387 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 652616005388 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 652616005389 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 652616005390 dimer interface [polypeptide binding]; other site 652616005391 active site 652616005392 heme binding site [chemical binding]; other site 652616005393 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 652616005394 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 652616005395 metal binding site 2 [ion binding]; metal-binding site 652616005396 putative DNA binding helix; other site 652616005397 metal binding site 1 [ion binding]; metal-binding site 652616005398 dimer interface [polypeptide binding]; other site 652616005399 structural Zn2+ binding site [ion binding]; other site 652616005400 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 652616005401 substrate binding site [chemical binding]; other site 652616005402 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 652616005403 substrate binding site [chemical binding]; other site 652616005404 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 652616005405 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR3; cd08275 652616005406 putative NAD(P) binding site [chemical binding]; other site 652616005407 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 652616005408 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 652616005409 tetramer interface [polypeptide binding]; other site 652616005410 active site 652616005411 Mg2+/Mn2+ binding site [ion binding]; other site 652616005412 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 652616005413 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616005414 PPE family; Region: PPE; pfam00823 652616005415 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616005416 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 652616005417 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 652616005418 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616005419 PPE family; Region: PPE; pfam00823 652616005420 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 652616005421 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 652616005422 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 652616005423 putative hydrophobic ligand binding site [chemical binding]; other site 652616005424 protein interface [polypeptide binding]; other site 652616005425 gate; other site 652616005426 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 652616005427 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 652616005428 putative acyl-acceptor binding pocket; other site 652616005429 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 652616005430 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 652616005431 Beta-lactamase; Region: Beta-lactamase; pfam00144 652616005432 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 652616005433 Beta-lactamase; Region: Beta-lactamase; pfam00144 652616005434 putative fatty-acid--CoA ligase; Provisional; Region: PRK12476 652616005435 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 652616005436 acyl-activating enzyme (AAE) consensus motif; other site 652616005437 active site 652616005438 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 652616005439 Uncharacterized conserved protein [Function unknown]; Region: COG3361 652616005440 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 652616005441 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 652616005442 TIGR03085 family protein; Region: TIGR03085 652616005443 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 652616005444 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 652616005445 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 652616005446 Helix-turn-helix domain; Region: HTH_18; pfam12833 652616005447 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 652616005448 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 652616005449 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 652616005450 dimer interface [polypeptide binding]; other site 652616005451 catalytic triad [active] 652616005452 peroxidatic and resolving cysteines [active] 652616005453 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 652616005454 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 652616005455 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 652616005456 active site 652616005457 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 652616005458 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 652616005459 FAD binding site [chemical binding]; other site 652616005460 substrate binding site [chemical binding]; other site 652616005461 catalytic base [active] 652616005462 enoyl-CoA hydratase; Provisional; Region: PRK08290 652616005463 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 652616005464 substrate binding site [chemical binding]; other site 652616005465 oxyanion hole (OAH) forming residues; other site 652616005466 trimer interface [polypeptide binding]; other site 652616005467 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 652616005468 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 652616005469 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 652616005470 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 652616005471 catalytic loop [active] 652616005472 iron binding site [ion binding]; other site 652616005473 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 652616005474 FAD binding pocket [chemical binding]; other site 652616005475 FAD binding motif [chemical binding]; other site 652616005476 phosphate binding motif [ion binding]; other site 652616005477 beta-alpha-beta structure motif; other site 652616005478 NAD binding pocket [chemical binding]; other site 652616005479 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 652616005480 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 652616005481 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 652616005482 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 652616005483 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 652616005484 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 652616005485 dimerization interface [polypeptide binding]; other site 652616005486 active site 652616005487 classical (c) SDR, subgroup 12; Region: SDR_c12; cd08944 652616005488 putative NAD(P) binding site [chemical binding]; other site 652616005489 active site 652616005490 homodimer interface [polypeptide binding]; other site 652616005491 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 652616005492 SEC-C motif; Region: SEC-C; pfam02810 652616005493 Domain of unknown function (DUF222); Region: DUF222; pfam02720 652616005494 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 652616005495 active site 652616005496 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 652616005497 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487 652616005498 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 652616005499 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 652616005500 non-specific DNA binding site [nucleotide binding]; other site 652616005501 salt bridge; other site 652616005502 sequence-specific DNA binding site [nucleotide binding]; other site 652616005503 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 652616005504 Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693 652616005505 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 652616005506 putative active site [active] 652616005507 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 652616005508 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 652616005509 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 652616005510 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 652616005511 Permease; Region: Permease; pfam02405 652616005512 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 652616005513 Permease; Region: Permease; pfam02405 652616005514 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 652616005515 mce related protein; Region: MCE; pfam02470 652616005516 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 652616005517 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 652616005518 mce related protein; Region: MCE; pfam02470 652616005519 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 652616005520 mce related protein; Region: MCE; pfam02470 652616005521 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 652616005522 mce related protein; Region: MCE; pfam02470 652616005523 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 652616005524 mce related protein; Region: MCE; pfam02470 652616005525 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 652616005526 mce related protein; Region: MCE; pfam02470 652616005527 Protein of unknown function (DUF732); Region: DUF732; pfam05305 652616005528 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 652616005529 YacP-like NYN domain; Region: NYN_YacP; cl01491 652616005530 Peptidase family M48; Region: Peptidase_M48; pfam01435 652616005531 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 652616005532 S-adenosylmethionine binding site [chemical binding]; other site 652616005533 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 652616005534 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 652616005535 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 652616005536 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 652616005537 dimer interface [polypeptide binding]; other site 652616005538 putative radical transfer pathway; other site 652616005539 diiron center [ion binding]; other site 652616005540 tyrosyl radical; other site 652616005541 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 652616005542 putative active site [active] 652616005543 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 652616005544 PE family; Region: PE; pfam00934 652616005545 Cutinase; Region: Cutinase; pfam01083 652616005546 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 652616005547 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 652616005548 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 652616005549 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 652616005550 dimerization interface [polypeptide binding]; other site 652616005551 Lysine efflux permease [General function prediction only]; Region: COG1279 652616005552 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 652616005553 S-adenosylmethionine binding site [chemical binding]; other site 652616005554 Uncharacterized conserved protein [Function unknown]; Region: COG5654 652616005555 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 652616005556 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 652616005557 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 652616005558 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 652616005559 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 652616005560 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 652616005561 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 652616005562 dimerization interface [polypeptide binding]; other site 652616005563 putative DNA binding site [nucleotide binding]; other site 652616005564 putative Zn2+ binding site [ion binding]; other site 652616005565 Hemerythrin-like domain; Region: Hr-like; cd12108 652616005566 Fe binding site [ion binding]; other site 652616005567 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 652616005568 Ligand Binding Site [chemical binding]; other site 652616005569 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 652616005570 Ligand Binding Site [chemical binding]; other site 652616005571 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 652616005572 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 652616005573 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 652616005574 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 652616005575 Soluble P-type ATPase [General function prediction only]; Region: COG4087 652616005576 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 652616005577 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 652616005578 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 652616005579 tetramer interface [polypeptide binding]; other site 652616005580 active site 652616005581 Mg2+/Mn2+ binding site [ion binding]; other site 652616005582 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 652616005583 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 652616005584 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 652616005585 3beta17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 3beta-17beta-HSD_like_SDR_c; cd05341 652616005586 homotetramer interface [polypeptide binding]; other site 652616005587 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 652616005588 NAD binding site [chemical binding]; other site 652616005589 homodimer interface [polypeptide binding]; other site 652616005590 active site 652616005591 Methyltransferase domain; Region: Methyltransf_23; pfam13489 652616005592 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 652616005593 S-adenosylmethionine binding site [chemical binding]; other site 652616005594 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 652616005595 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 652616005596 Predicted kinase [General function prediction only]; Region: COG0645 652616005597 AAA domain; Region: AAA_17; pfam13207 652616005598 Universal stress protein family; Region: Usp; pfam00582 652616005599 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 652616005600 Ligand Binding Site [chemical binding]; other site 652616005601 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 652616005602 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 652616005603 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 652616005604 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 652616005605 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 652616005606 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 652616005607 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 652616005608 Ferredoxin [Energy production and conversion]; Region: COG1146 652616005609 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 652616005610 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 652616005611 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 652616005612 Walker A motif; other site 652616005613 ATP binding site [chemical binding]; other site 652616005614 Walker B motif; other site 652616005615 arginine finger; other site 652616005616 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 652616005617 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 652616005618 putative active site [active] 652616005619 Transcriptional regulators [Transcription]; Region: MarR; COG1846 652616005620 MarR family; Region: MarR_2; pfam12802 652616005621 Phage envelope protein [General function prediction only]; Region: COG5562 652616005622 Predicted helicase [General function prediction only]; Region: COG4889 652616005623 Transposase; Region: DEDD_Tnp_IS110; pfam01548 652616005624 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 652616005625 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 652616005626 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 652616005627 Domain of unknown function (DUF222); Region: DUF222; pfam02720 652616005628 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 652616005629 active site 652616005630 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 652616005631 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 652616005632 non-specific DNA binding site [nucleotide binding]; other site 652616005633 salt bridge; other site 652616005634 sequence-specific DNA binding site [nucleotide binding]; other site 652616005635 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 652616005636 Uncharacterized conserved protein [Function unknown]; Region: COG2442 652616005637 Predicted helicase [General function prediction only]; Region: COG4889 652616005638 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 652616005639 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 652616005640 non-specific DNA binding site [nucleotide binding]; other site 652616005641 salt bridge; other site 652616005642 sequence-specific DNA binding site [nucleotide binding]; other site 652616005643 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4683 652616005644 Predicted helicase [General function prediction only]; Region: COG4889 652616005645 Restriction endonuclease; Region: Mrr_cat_2; pfam13156 652616005646 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 652616005647 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 652616005648 ATP binding site [chemical binding]; other site 652616005649 putative Mg++ binding site [ion binding]; other site 652616005650 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 652616005651 ATP-binding site [chemical binding]; other site 652616005652 Methyltransferase domain; Region: Methyltransf_26; pfam13659 652616005653 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 652616005654 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 652616005655 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 652616005656 Ligand Binding Site [chemical binding]; other site 652616005657 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 652616005658 Ligand Binding Site [chemical binding]; other site 652616005659 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 652616005660 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 652616005661 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 652616005662 Histidine kinase; Region: HisKA_3; pfam07730 652616005663 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 652616005664 Ligand Binding Site [chemical binding]; other site 652616005665 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 652616005666 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 652616005667 putative substrate binding site [chemical binding]; other site 652616005668 putative ATP binding site [chemical binding]; other site 652616005669 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 652616005670 active site 652616005671 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 652616005672 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 652616005673 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 652616005674 putative dimer interface [polypeptide binding]; other site 652616005675 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 652616005676 dimer interface [polypeptide binding]; other site 652616005677 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 652616005678 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 652616005679 putative DNA binding site [nucleotide binding]; other site 652616005680 dimerization interface [polypeptide binding]; other site 652616005681 putative Zn2+ binding site [ion binding]; other site 652616005682 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 652616005683 putative hydrophobic ligand binding site [chemical binding]; other site 652616005684 CLM binding site; other site 652616005685 L1 loop; other site 652616005686 DNA binding site [nucleotide binding] 652616005687 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 652616005688 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 652616005689 MDMPI C-terminal domain; Region: MDMPI_C; pfam07398 652616005690 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 652616005691 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 652616005692 nucleophile elbow; other site 652616005693 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 652616005694 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 652616005695 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 652616005696 Walker A/P-loop; other site 652616005697 ATP binding site [chemical binding]; other site 652616005698 Q-loop/lid; other site 652616005699 ABC transporter signature motif; other site 652616005700 Walker B; other site 652616005701 D-loop; other site 652616005702 H-loop/switch region; other site 652616005703 TOBE domain; Region: TOBE_2; pfam08402 652616005704 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 652616005705 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 652616005706 dimer interface [polypeptide binding]; other site 652616005707 conserved gate region; other site 652616005708 putative PBP binding loops; other site 652616005709 ABC-ATPase subunit interface; other site 652616005710 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 652616005711 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 652616005712 dimer interface [polypeptide binding]; other site 652616005713 conserved gate region; other site 652616005714 putative PBP binding loops; other site 652616005715 ABC-ATPase subunit interface; other site 652616005716 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 652616005717 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 652616005718 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 652616005719 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 652616005720 Isochorismatase family; Region: Isochorismatase; pfam00857 652616005721 catalytic triad [active] 652616005722 metal binding site [ion binding]; metal-binding site 652616005723 conserved cis-peptide bond; other site 652616005724 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 652616005725 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 652616005726 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 652616005727 substrate binding pocket [chemical binding]; other site 652616005728 catalytic triad [active] 652616005729 hypothetical protein; Provisional; Region: PRK05865 652616005730 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 652616005731 NAD(P) binding site [chemical binding]; other site 652616005732 active site 652616005733 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 652616005734 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 652616005735 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 652616005736 active site 652616005737 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 652616005738 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 652616005739 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 652616005740 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 652616005741 Enoylreductase; Region: PKS_ER; smart00829 652616005742 NAD(P) binding site [chemical binding]; other site 652616005743 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 652616005744 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 652616005745 putative NADP binding site [chemical binding]; other site 652616005746 active site 652616005747 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 652616005748 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 652616005749 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 652616005750 active site 652616005751 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 652616005752 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 652616005753 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 652616005754 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 652616005755 Enoylreductase; Region: PKS_ER; smart00829 652616005756 NAD(P) binding site [chemical binding]; other site 652616005757 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 652616005758 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 652616005759 putative NADP binding site [chemical binding]; other site 652616005760 active site 652616005761 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 652616005762 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 652616005763 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 652616005764 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 652616005765 putative active site [active] 652616005766 catalytic triad [active] 652616005767 putative dimer interface [polypeptide binding]; other site 652616005768 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 652616005769 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 652616005770 Ligand binding site; other site 652616005771 Putative Catalytic site; other site 652616005772 DXD motif; other site 652616005773 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 652616005774 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 652616005775 active site 652616005776 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 652616005777 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 652616005778 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 652616005779 30S ribosomal protein S18; Provisional; Region: PRK13401 652616005780 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 652616005781 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 652616005782 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 652616005783 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 652616005784 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 652616005785 intersubunit interface [polypeptide binding]; other site 652616005786 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 652616005787 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 652616005788 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 652616005789 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 652616005790 precorrin-3B synthase; Region: CobG; TIGR02435 652616005791 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 652616005792 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 652616005793 Precorrin-8X methylmutase; Region: CbiC; pfam02570 652616005794 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 652616005795 active site 652616005796 SAM binding site [chemical binding]; other site 652616005797 homodimer interface [polypeptide binding]; other site 652616005798 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 652616005799 active site 652616005800 SAM binding site [chemical binding]; other site 652616005801 homodimer interface [polypeptide binding]; other site 652616005802 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 652616005803 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 652616005804 RNA polymerase sigma factor SigC; Reviewed; Region: PRK09649 652616005805 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 652616005806 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 652616005807 DNA binding residues [nucleotide binding] 652616005808 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 652616005809 precorrin-6x reductase; Region: precor6x_red; TIGR00715 652616005810 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 652616005811 active site 652616005812 SAM binding site [chemical binding]; other site 652616005813 homodimer interface [polypeptide binding]; other site 652616005814 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 652616005815 active site 652616005816 putative homodimer interface [polypeptide binding]; other site 652616005817 SAM binding site [chemical binding]; other site 652616005818 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 652616005819 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 652616005820 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 652616005821 NAD(P) binding site [chemical binding]; other site 652616005822 active site 652616005823 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 652616005824 Catalytic domain of uncharacterized Mycobacterium tuberculosis Rv2075c-like proteins; Region: PI-PLCc_Rv2075c_like; cd08590 652616005825 putative active site [active] 652616005826 catalytic site [active] 652616005827 putative metal binding site [ion binding]; other site 652616005828 C-type lectin (CTL)/C-type lectin-like (CTLD) domain; Region: CLECT; cl02432 652616005829 Protein of unknown function (DUF2563); Region: DUF2563; pfam10817 652616005830 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 652616005831 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 652616005832 Catalytic domain of Protein Kinases; Region: PKc; cd00180 652616005833 active site 652616005834 ATP binding site [chemical binding]; other site 652616005835 substrate binding site [chemical binding]; other site 652616005836 activation loop (A-loop); other site 652616005837 PknH-like extracellular domain; Region: PknH_C; pfam14032 652616005838 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 652616005839 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 652616005840 active site 652616005841 5'-3' exonuclease, N-terminal resolvase-like domain; Region: 5_3_exonuc_N; pfam02739 652616005842 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 652616005843 active site 652616005844 metal binding site 1 [ion binding]; metal-binding site 652616005845 putative 5' ssDNA interaction site; other site 652616005846 metal binding site 3; metal-binding site 652616005847 metal binding site 2 [ion binding]; metal-binding site 652616005848 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 652616005849 putative DNA binding site [nucleotide binding]; other site 652616005850 putative metal binding site [ion binding]; other site 652616005851 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 652616005852 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 652616005853 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 652616005854 ATP binding site [chemical binding]; other site 652616005855 putative Mg++ binding site [ion binding]; other site 652616005856 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 652616005857 nucleotide binding region [chemical binding]; other site 652616005858 ATP-binding site [chemical binding]; other site 652616005859 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 652616005860 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 652616005861 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 652616005862 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 652616005863 Predicted transcriptional regulator [Transcription]; Region: COG2378 652616005864 WYL domain; Region: WYL; pfam13280 652616005865 Predicted transcriptional regulator [Transcription]; Region: COG2378 652616005866 WYL domain; Region: WYL; pfam13280 652616005867 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 652616005868 PE family; Region: PE; pfam00934 652616005869 Domain of unknown function (DUF222); Region: DUF222; pfam02720 652616005870 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 652616005871 active site 652616005872 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 652616005873 SNF2 Helicase protein; Region: DUF3670; pfam12419 652616005874 Uncharacterized conserved protein [Function unknown]; Region: COG4279 652616005875 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 652616005876 putative active site [active] 652616005877 PE family; Region: PE; pfam00934 652616005878 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616005879 PPE family; Region: PPE; pfam00823 652616005880 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 652616005881 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 652616005882 active site 652616005883 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 652616005884 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 652616005885 active site 652616005886 Pup-like protein; Region: Pup; pfam05639 652616005887 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 652616005888 proteasome ATPase; Region: pup_AAA; TIGR03689 652616005889 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 652616005890 Walker A motif; other site 652616005891 ATP binding site [chemical binding]; other site 652616005892 Walker B motif; other site 652616005893 arginine finger; other site 652616005894 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 652616005895 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550 652616005896 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 652616005897 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 652616005898 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 652616005899 Predicted membrane protein [Function unknown]; Region: COG3918 652616005900 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 652616005901 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 652616005902 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 652616005903 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 652616005904 homodimer interface [polypeptide binding]; other site 652616005905 putative metal binding site [ion binding]; other site 652616005906 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616005907 PPE family; Region: PPE; pfam00823 652616005908 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 652616005909 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 652616005910 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 652616005911 substrate binding pocket [chemical binding]; other site 652616005912 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 652616005913 B12 binding site [chemical binding]; other site 652616005914 cobalt ligand [ion binding]; other site 652616005915 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 652616005916 PAC2 family; Region: PAC2; pfam09754 652616005917 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 652616005918 short chain dehydrogenase; Provisional; Region: PRK05872 652616005919 classical (c) SDRs; Region: SDR_c; cd05233 652616005920 NAD(P) binding site [chemical binding]; other site 652616005921 active site 652616005922 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 652616005923 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 652616005924 active site 652616005925 HIGH motif; other site 652616005926 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 652616005927 active site 652616005928 KMSKS motif; other site 652616005929 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 652616005930 putative tRNA binding surface [nucleotide binding]; other site 652616005931 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 652616005932 active site 652616005933 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 652616005934 conserved hypothetical protein; Region: TIGR03843 652616005935 conserved hypothetical protein; Region: TIGR03847 652616005936 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 652616005937 catalytic core [active] 652616005938 undecaprenyl-diphosphatase UppP; Region: undec_PP_bacA; TIGR00753 652616005939 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 652616005940 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 652616005941 quinone interaction residues [chemical binding]; other site 652616005942 active site 652616005943 catalytic residues [active] 652616005944 FMN binding site [chemical binding]; other site 652616005945 substrate binding site [chemical binding]; other site 652616005946 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 652616005947 substrate binding site [chemical binding]; other site 652616005948 hypothetical protein; Provisional; Region: PRK07906 652616005949 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 652616005950 putative metal binding site [ion binding]; other site 652616005951 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 652616005952 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 652616005953 active site 652616005954 DivIVA domain; Region: DivI1A_domain; TIGR03544 652616005955 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 652616005956 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 652616005957 Predicted integral membrane protein [Function unknown]; Region: COG0762 652616005958 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 652616005959 Predicted enzyme with a TIM-barrel fold [General function prediction only]; Region: COG0325 652616005960 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 652616005961 catalytic residue [active] 652616005962 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 652616005963 uncharacterized protein, YfiH family; Region: TIGR00726 652616005964 cell division protein FtsZ; Validated; Region: PRK09330 652616005965 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 652616005966 nucleotide binding site [chemical binding]; other site 652616005967 SulA interaction site; other site 652616005968 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 652616005969 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 652616005970 Cell division protein FtsQ; Region: FtsQ; pfam03799 652616005971 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 652616005972 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 652616005973 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 652616005974 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 652616005975 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 652616005976 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 652616005977 active site 652616005978 homodimer interface [polypeptide binding]; other site 652616005979 cell division protein FtsW; Region: ftsW; TIGR02614 652616005980 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369 652616005981 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 652616005982 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 652616005983 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 652616005984 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 652616005985 Mg++ binding site [ion binding]; other site 652616005986 putative catalytic motif [active] 652616005987 putative substrate binding site [chemical binding]; other site 652616005988 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 652616005989 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 652616005990 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 652616005991 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 652616005992 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 652616005993 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 652616005994 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 652616005995 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 652616005996 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 652616005997 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 652616005998 PE family; Region: PE; pfam00934 652616005999 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 652616006000 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 652616006001 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 652616006002 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 652616006003 MraW methylase family; Region: Methyltransf_5; pfam01795 652616006004 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 652616006005 MraZ protein; Region: MraZ; pfam02381 652616006006 MraZ protein; Region: MraZ; pfam02381 652616006007 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 652616006008 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 652616006009 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 652616006010 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 652616006011 substrate binding pocket [chemical binding]; other site 652616006012 chain length determination region; other site 652616006013 substrate-Mg2+ binding site; other site 652616006014 catalytic residues [active] 652616006015 aspartate-rich region 1; other site 652616006016 active site lid residues [active] 652616006017 aspartate-rich region 2; other site 652616006018 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 652616006019 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 652616006020 Catalytic domain of Protein Kinases; Region: PKc; cd00180 652616006021 active site 652616006022 ATP binding site [chemical binding]; other site 652616006023 substrate binding site [chemical binding]; other site 652616006024 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 652616006025 substrate binding site [chemical binding]; other site 652616006026 activation loop (A-loop); other site 652616006027 activation loop (A-loop); other site 652616006028 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 652616006029 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 652616006030 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG3200 652616006031 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 652616006032 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 652616006033 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 652616006034 putative acyl-acceptor binding pocket; other site 652616006035 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 652616006036 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 652616006037 DTAP/Switch II; other site 652616006038 Switch I; other site 652616006039 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 652616006040 putative hydrophobic ligand binding site [chemical binding]; other site 652616006041 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 652616006042 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 652616006043 acyl-activating enzyme (AAE) consensus motif; other site 652616006044 putative AMP binding site [chemical binding]; other site 652616006045 putative active site [active] 652616006046 putative CoA binding site [chemical binding]; other site 652616006047 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 652616006048 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 652616006049 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 652616006050 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 652616006051 NlpC/P60 family; Region: NLPC_P60; cl17555 652616006052 hypothetical protein; Validated; Region: PRK07883 652616006053 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 652616006054 active site 652616006055 catalytic site [active] 652616006056 substrate binding site [chemical binding]; other site 652616006057 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 652616006058 GIY-YIG motif/motif A; other site 652616006059 active site 652616006060 catalytic site [active] 652616006061 putative DNA binding site [nucleotide binding]; other site 652616006062 metal binding site [ion binding]; metal-binding site 652616006063 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 652616006064 Subunit I/III interface [polypeptide binding]; other site 652616006065 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 652616006066 Cytochrome c; Region: Cytochrom_C; pfam00034 652616006067 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 652616006068 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 652616006069 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 652616006070 iron-sulfur cluster [ion binding]; other site 652616006071 [2Fe-2S] cluster binding site [ion binding]; other site 652616006072 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 652616006073 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 652616006074 heme bH binding site [chemical binding]; other site 652616006075 intrachain domain interface; other site 652616006076 heme bL binding site [chemical binding]; other site 652616006077 interchain domain interface [polypeptide binding]; other site 652616006078 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 652616006079 Qo binding site; other site 652616006080 Protein of unknown function (DUF2561); Region: DUF2561; pfam10812 652616006081 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 652616006082 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 652616006083 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 652616006084 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 652616006085 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 652616006086 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 652616006087 dimer interface [polypeptide binding]; other site 652616006088 active site 652616006089 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 652616006090 Ligand Binding Site [chemical binding]; other site 652616006091 Molecular Tunnel; other site 652616006092 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 652616006093 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 652616006094 substrate binding site [chemical binding]; other site 652616006095 ATP binding site [chemical binding]; other site 652616006096 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 652616006097 Glycerate kinase family; Region: Gly_kinase; pfam02595 652616006098 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 652616006099 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 652616006100 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 652616006101 putative dimer interface [polypeptide binding]; other site 652616006102 active site pocket [active] 652616006103 putative cataytic base [active] 652616006104 Cobalamin-5-phosphate synthase; Region: CobS; pfam02654 652616006105 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 652616006106 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 652616006107 homodimer interface [polypeptide binding]; other site 652616006108 substrate-cofactor binding pocket; other site 652616006109 catalytic residue [active] 652616006110 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 652616006111 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 652616006112 cyclase homology domain; Region: CHD; cd07302 652616006113 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 652616006114 nucleotidyl binding site; other site 652616006115 metal binding site [ion binding]; metal-binding site 652616006116 dimer interface [polypeptide binding]; other site 652616006117 multifunctional aminopeptidase A; Provisional; Region: PRK00913 652616006118 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 652616006119 interface (dimer of trimers) [polypeptide binding]; other site 652616006120 Substrate-binding/catalytic site; other site 652616006121 Zn-binding sites [ion binding]; other site 652616006122 short chain dehydrogenase; Validated; Region: PRK05855 652616006123 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 652616006124 classical (c) SDRs; Region: SDR_c; cd05233 652616006125 NAD(P) binding site [chemical binding]; other site 652616006126 active site 652616006127 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 652616006128 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 652616006129 E3 interaction surface; other site 652616006130 lipoyl attachment site [posttranslational modification]; other site 652616006131 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 652616006132 E3 interaction surface; other site 652616006133 lipoyl attachment site [posttranslational modification]; other site 652616006134 e3 binding domain; Region: E3_binding; pfam02817 652616006135 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 652616006136 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 652616006137 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 652616006138 putative NAD(P) binding site [chemical binding]; other site 652616006139 putative active site [active] 652616006140 lipoate-protein ligase B; Provisional; Region: PRK14345 652616006141 lipoyl synthase; Provisional; Region: PRK05481 652616006142 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 652616006143 FeS/SAM binding site; other site 652616006144 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 652616006145 RDD family; Region: RDD; pfam06271 652616006146 glutamine synthetase, type I; Region: GlnA; TIGR00653 652616006147 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 652616006148 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 652616006149 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 652616006150 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 652616006151 metal binding triad; other site 652616006152 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 652616006153 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 652616006154 metal binding triad; other site 652616006155 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 652616006156 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 652616006157 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 652616006158 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 652616006159 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 652616006160 TAP-like protein; Region: Abhydrolase_4; pfam08386 652616006161 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 652616006162 TAP-like protein; Region: Abhydrolase_4; pfam08386 652616006163 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 652616006164 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 652616006165 active site 652616006166 oligomerization interface [polypeptide binding]; other site 652616006167 metal binding site [ion binding]; metal-binding site 652616006168 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 652616006169 putative active site; other site 652616006170 putative metal binding residues [ion binding]; other site 652616006171 signature motif; other site 652616006172 putative triphosphate binding site [ion binding]; other site 652616006173 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 652616006174 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; cl17606 652616006175 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3826 652616006176 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 652616006177 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 652616006178 RNA/DNA hybrid binding site [nucleotide binding]; other site 652616006179 active site 652616006180 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 652616006181 catalytic core [active] 652616006182 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 652616006183 Putative zinc ribbon domain; Region: DUF164; pfam02591 652616006184 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 652616006185 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 652616006186 Uncharacterized conserved protein [Function unknown]; Region: COG0327 652616006187 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 652616006188 hypothetical protein; Provisional; Region: PRK07908 652616006189 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 652616006190 pyridoxal 5'-phosphate binding site [chemical binding]; other site 652616006191 homodimer interface [polypeptide binding]; other site 652616006192 catalytic residue [active] 652616006193 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 652616006194 phosphoglycolate phosphatase; Provisional; Region: PRK13222 652616006195 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 652616006196 active site 652616006197 motif I; other site 652616006198 motif II; other site 652616006199 Low molecular weight phosphatase family; Region: LMWPc; cd00115 652616006200 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 652616006201 active site 652616006202 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 652616006203 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 652616006204 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 652616006205 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 652616006206 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 652616006207 dimer interface [polypeptide binding]; other site 652616006208 catalytic triad [active] 652616006209 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 652616006210 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 652616006211 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 652616006212 dimer interface [polypeptide binding]; other site 652616006213 TPP-binding site [chemical binding]; other site 652616006214 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 652616006215 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 652616006216 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 652616006217 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 652616006218 acyl carrier protein; Provisional; Region: acpP; PRK00982 652616006219 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 652616006220 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 652616006221 dimer interface [polypeptide binding]; other site 652616006222 active site 652616006223 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 652616006224 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 652616006225 dimer interface [polypeptide binding]; other site 652616006226 active site 652616006227 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 652616006228 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 652616006229 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 652616006230 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 652616006231 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 652616006232 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 652616006233 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 652616006234 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 652616006235 FAD binding domain; Region: FAD_binding_4; pfam01565 652616006236 diacylglycerol kinase; Reviewed; Region: PRK11914 652616006237 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 652616006238 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 652616006239 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 652616006240 Beta-lactamase; Region: Beta-lactamase; pfam00144 652616006241 Methyltransferase domain; Region: Methyltransf_31; pfam13847 652616006242 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 652616006243 S-adenosylmethionine binding site [chemical binding]; other site 652616006244 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 652616006245 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 652616006246 NAD binding site [chemical binding]; other site 652616006247 catalytic Zn binding site [ion binding]; other site 652616006248 substrate binding site [chemical binding]; other site 652616006249 structural Zn binding site [ion binding]; other site 652616006250 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 652616006251 short chain dehydrogenase; Provisional; Region: PRK05854 652616006252 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 652616006253 putative NAD(P) binding site [chemical binding]; other site 652616006254 active site 652616006255 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 652616006256 nucleotide binding site [chemical binding]; other site 652616006257 Major Facilitator Superfamily; Region: MFS_1; pfam07690 652616006258 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 652616006259 Cytochrome P450; Region: p450; cl12078 652616006260 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 652616006261 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 652616006262 Cytochrome P450; Region: p450; cl12078 652616006263 Septum formation; Region: Septum_form; pfam13845 652616006264 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 652616006265 FAD binding domain; Region: FAD_binding_4; pfam01565 652616006266 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 652616006267 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 652616006268 Transcriptional regulator [Transcription]; Region: LysR; COG0583 652616006269 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 652616006270 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 652616006271 dimerization interface [polypeptide binding]; other site 652616006272 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 652616006273 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 652616006274 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 652616006275 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 652616006276 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 652616006277 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 652616006278 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 652616006279 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 652616006280 CDP-diacylglycerol pyrophosphatase [Lipid metabolism]; Region: Cdh; COG2134 652616006281 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 652616006282 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 652616006283 active site residue [active] 652616006284 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 652616006285 active site residue [active] 652616006286 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 652616006287 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 652616006288 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 652616006289 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 652616006290 pyridoxal 5'-phosphate binding site [chemical binding]; other site 652616006291 homodimer interface [polypeptide binding]; other site 652616006292 catalytic residue [active] 652616006293 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3196 652616006294 haloalkane dehalogenase; Provisional; Region: PRK00870 652616006295 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 652616006296 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 652616006297 active site 652616006298 catalytic tetrad [active] 652616006299 heat shock protein 90; Provisional; Region: PRK05218 652616006300 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 652616006301 ATP binding site [chemical binding]; other site 652616006302 Mg2+ binding site [ion binding]; other site 652616006303 G-X-G motif; other site 652616006304 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 652616006305 Cutinase; Region: Cutinase; pfam01083 652616006306 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 652616006307 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 652616006308 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 652616006309 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 652616006310 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 652616006311 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 652616006312 Uncharacterized conserved protein [Function unknown]; Region: COG2442 652616006313 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 652616006314 DNA binding site [nucleotide binding] 652616006315 active site 652616006316 Int/Topo IB signature motif; other site 652616006317 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 652616006318 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 652616006319 DNA binding residues [nucleotide binding] 652616006320 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507 652616006321 Uncharacterized conserved protein [Function unknown]; Region: COG2128 652616006322 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 652616006323 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 652616006324 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 652616006325 putative PBP binding loops; other site 652616006326 ABC-ATPase subunit interface; other site 652616006327 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 652616006328 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 652616006329 dimer interface [polypeptide binding]; other site 652616006330 conserved gate region; other site 652616006331 putative PBP binding loops; other site 652616006332 ABC-ATPase subunit interface; other site 652616006333 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 652616006334 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 652616006335 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 652616006336 Ligand Binding Site [chemical binding]; other site 652616006337 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 652616006338 Ligand Binding Site [chemical binding]; other site 652616006339 amino acid transporter; Region: 2A0306; TIGR00909 652616006340 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 652616006341 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 652616006342 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 652616006343 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 652616006344 catalytic residue [active] 652616006345 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 652616006346 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 652616006347 Amidinotransferase; Region: Amidinotransf; pfam02274 652616006348 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 652616006349 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 652616006350 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 652616006351 putative DNA binding site [nucleotide binding]; other site 652616006352 putative Zn2+ binding site [ion binding]; other site 652616006353 AsnC family; Region: AsnC_trans_reg; pfam01037 652616006354 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 652616006355 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 652616006356 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 652616006357 Walker A/P-loop; other site 652616006358 ATP binding site [chemical binding]; other site 652616006359 Q-loop/lid; other site 652616006360 ABC transporter signature motif; other site 652616006361 Walker B; other site 652616006362 D-loop; other site 652616006363 H-loop/switch region; other site 652616006364 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 652616006365 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 652616006366 Walker A/P-loop; other site 652616006367 ATP binding site [chemical binding]; other site 652616006368 Q-loop/lid; other site 652616006369 ABC transporter signature motif; other site 652616006370 Walker B; other site 652616006371 D-loop; other site 652616006372 H-loop/switch region; other site 652616006373 MarR family; Region: MarR; pfam01047 652616006374 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 652616006375 PE family; Region: PE; pfam00934 652616006376 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 652616006377 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 652616006378 putative substrate translocation pore; other site 652616006379 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 652616006380 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 652616006381 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 652616006382 malate dehydrogenase; Provisional; Region: PRK13529 652616006383 Malic enzyme, N-terminal domain; Region: malic; pfam00390 652616006384 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 652616006385 NAD(P) binding site [chemical binding]; other site 652616006386 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 652616006387 Major Facilitator Superfamily; Region: MFS_1; pfam07690 652616006388 putative substrate translocation pore; other site 652616006389 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 652616006390 putative substrate translocation pore; other site 652616006391 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 652616006392 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 652616006393 dimer interface [polypeptide binding]; other site 652616006394 pyridoxal 5'-phosphate binding site [chemical binding]; other site 652616006395 catalytic residue [active] 652616006396 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 652616006397 serine O-acetyltransferase; Region: cysE; TIGR01172 652616006398 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 652616006399 trimer interface [polypeptide binding]; other site 652616006400 active site 652616006401 substrate binding site [chemical binding]; other site 652616006402 CoA binding site [chemical binding]; other site 652616006403 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 652616006404 Transposase; Region: HTH_Tnp_1; cl17663 652616006405 putative transposase OrfB; Reviewed; Region: PHA02517 652616006406 HTH-like domain; Region: HTH_21; pfam13276 652616006407 Integrase core domain; Region: rve; pfam00665 652616006408 Integrase core domain; Region: rve_3; pfam13683 652616006409 hypothetical protein; Provisional; Region: PRK14851 652616006410 hypothetical protein; Validated; Region: PRK08223 652616006411 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 652616006412 ATP binding site [chemical binding]; other site 652616006413 substrate interface [chemical binding]; other site 652616006414 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 652616006415 PE family; Region: PE; pfam00934 652616006416 DNA primase; Validated; Region: dnaG; PRK05667 652616006417 CHC2 zinc finger; Region: zf-CHC2; pfam01807 652616006418 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 652616006419 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 652616006420 active site 652616006421 metal binding site [ion binding]; metal-binding site 652616006422 interdomain interaction site; other site 652616006423 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 652616006424 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 652616006425 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 652616006426 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 652616006427 Zn2+ binding site [ion binding]; other site 652616006428 Mg2+ binding site [ion binding]; other site 652616006429 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 652616006430 Repair protein; Region: Repair_PSII; pfam04536 652616006431 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 652616006432 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 652616006433 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 652616006434 Phosphoesterase family; Region: Phosphoesterase; pfam04185 652616006435 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 652616006436 Phosphoesterase family; Region: Phosphoesterase; pfam04185 652616006437 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 652616006438 Phosphoesterase family; Region: Phosphoesterase; pfam04185 652616006439 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616006440 PPE family; Region: PPE; pfam00823 652616006441 putative transposase OrfB; Reviewed; Region: PHA02517 652616006442 HTH-like domain; Region: HTH_21; pfam13276 652616006443 Integrase core domain; Region: rve; pfam00665 652616006444 Integrase core domain; Region: rve_3; pfam13683 652616006445 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 652616006446 Transposase; Region: HTH_Tnp_1; cl17663 652616006447 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616006448 PPE family; Region: PPE; pfam00823 652616006449 PPE family; Region: PPE; pfam00823 652616006450 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616006451 PPE family; Region: PPE; pfam00823 652616006452 PPE family; Region: PPE; pfam00823 652616006453 PPE family; Region: PPE; pfam00823 652616006454 glycyl-tRNA synthetase; Provisional; Region: PRK04173 652616006455 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 652616006456 motif 1; other site 652616006457 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 652616006458 active site 652616006459 motif 2; other site 652616006460 motif 3; other site 652616006461 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 652616006462 anticodon binding site; other site 652616006463 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 652616006464 dimerization interface [polypeptide binding]; other site 652616006465 putative DNA binding site [nucleotide binding]; other site 652616006466 putative Zn2+ binding site [ion binding]; other site 652616006467 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 652616006468 metal binding site 2 [ion binding]; metal-binding site 652616006469 putative DNA binding helix; other site 652616006470 metal binding site 1 [ion binding]; metal-binding site 652616006471 dimer interface [polypeptide binding]; other site 652616006472 structural Zn2+ binding site [ion binding]; other site 652616006473 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 652616006474 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 652616006475 catalytic residue [active] 652616006476 putative FPP diphosphate binding site; other site 652616006477 putative FPP binding hydrophobic cleft; other site 652616006478 dimer interface [polypeptide binding]; other site 652616006479 putative IPP diphosphate binding site; other site 652616006480 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 652616006481 Recombination protein O N terminal; Region: RecO_N; pfam11967 652616006482 Recombination protein O C terminal; Region: RecO_C; pfam02565 652616006483 amidase; Provisional; Region: PRK06061 652616006484 Amidase; Region: Amidase; pfam01425 652616006485 GTPase Era; Reviewed; Region: era; PRK00089 652616006486 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 652616006487 G1 box; other site 652616006488 GTP/Mg2+ binding site [chemical binding]; other site 652616006489 Switch I region; other site 652616006490 G2 box; other site 652616006491 Switch II region; other site 652616006492 G3 box; other site 652616006493 G4 box; other site 652616006494 G5 box; other site 652616006495 KH domain; Region: KH_2; pfam07650 652616006496 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 652616006497 Domain of unknown function DUF21; Region: DUF21; pfam01595 652616006498 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 652616006499 Transporter associated domain; Region: CorC_HlyC; smart01091 652616006500 metal-binding heat shock protein; Provisional; Region: PRK00016 652616006501 K homology RNA-binding domain; Region: KH; smart00322 652616006502 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 652616006503 PhoH-like protein; Region: PhoH; pfam02562 652616006504 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 652616006505 PE family; Region: PE; pfam00934 652616006506 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 652616006507 RNA methyltransferase, RsmE family; Region: TIGR00046 652616006508 chaperone protein DnaJ; Provisional; Region: PRK14278 652616006509 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 652616006510 HSP70 interaction site [polypeptide binding]; other site 652616006511 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 652616006512 Zn binding sites [ion binding]; other site 652616006513 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 652616006514 dimer interface [polypeptide binding]; other site 652616006515 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 652616006516 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 652616006517 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 652616006518 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 652616006519 Condensation domain; Region: Condensation; pfam00668 652616006520 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 652616006521 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 652616006522 acyl-activating enzyme (AAE) consensus motif; other site 652616006523 AMP binding site [chemical binding]; other site 652616006524 Condensation domain; Region: Condensation; pfam00668 652616006525 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 652616006526 Condensation domain; Region: Condensation; pfam00668 652616006527 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 652616006528 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 652616006529 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 652616006530 acyl-activating enzyme (AAE) consensus motif; other site 652616006531 AMP binding site [chemical binding]; other site 652616006532 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 652616006533 Condensation domain; Region: Condensation; pfam00668 652616006534 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 652616006535 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 652616006536 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 652616006537 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 652616006538 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 652616006539 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 652616006540 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 652616006541 NADP binding site [chemical binding]; other site 652616006542 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 652616006543 active site 652616006544 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 652616006545 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 652616006546 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 652616006547 active site 652616006548 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 652616006549 Condensation domain; Region: Condensation; pfam00668 652616006550 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 652616006551 Nonribosomal peptide synthase; Region: NRPS; pfam08415 652616006552 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 652616006553 acyl-activating enzyme (AAE) consensus motif; other site 652616006554 AMP binding site [chemical binding]; other site 652616006555 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 652616006556 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 652616006557 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 652616006558 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 652616006559 acyl-activating enzyme (AAE) consensus motif; other site 652616006560 active site 652616006561 AMP binding site [chemical binding]; other site 652616006562 substrate binding site [chemical binding]; other site 652616006563 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 652616006564 salicylate synthase MbtI; Reviewed; Region: PRK07912 652616006565 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 652616006566 Predicted permease [General function prediction only]; Region: COG3329 652616006567 coproporphyrinogen III oxidase; Validated; Region: PRK05628 652616006568 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 652616006569 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 652616006570 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 652616006571 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 652616006572 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 652616006573 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 652616006574 Active Sites [active] 652616006575 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 652616006576 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 652616006577 putative active site [active] 652616006578 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 652616006579 putative active site [active] 652616006580 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 652616006581 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 652616006582 Predicted membrane protein [Function unknown]; Region: COG1297 652616006583 putative oligopeptide transporter, OPT family; Region: TIGR00733 652616006584 PE family; Region: PE; pfam00934 652616006585 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 652616006586 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 652616006587 Walker A/P-loop; other site 652616006588 ATP binding site [chemical binding]; other site 652616006589 Q-loop/lid; other site 652616006590 ABC transporter signature motif; other site 652616006591 Walker B; other site 652616006592 D-loop; other site 652616006593 H-loop/switch region; other site 652616006594 sulfate transport protein; Provisional; Region: cysT; CHL00187 652616006595 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 652616006596 dimer interface [polypeptide binding]; other site 652616006597 conserved gate region; other site 652616006598 putative PBP binding loops; other site 652616006599 ABC-ATPase subunit interface; other site 652616006600 sulfate transport protein; Provisional; Region: cysT; CHL00187 652616006601 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 652616006602 dimer interface [polypeptide binding]; other site 652616006603 conserved gate region; other site 652616006604 putative PBP binding loops; other site 652616006605 ABC-ATPase subunit interface; other site 652616006606 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 652616006607 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 652616006608 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 652616006609 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 652616006610 PknH-like extracellular domain; Region: PknH_C; pfam14032 652616006611 GTP-binding protein LepA; Provisional; Region: PRK05433 652616006612 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 652616006613 G1 box; other site 652616006614 putative GEF interaction site [polypeptide binding]; other site 652616006615 GTP/Mg2+ binding site [chemical binding]; other site 652616006616 Switch I region; other site 652616006617 G2 box; other site 652616006618 G3 box; other site 652616006619 Switch II region; other site 652616006620 G4 box; other site 652616006621 G5 box; other site 652616006622 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 652616006623 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 652616006624 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 652616006625 PemK-like protein; Region: PemK; pfam02452 652616006626 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 652616006627 FOG: CBS domain [General function prediction only]; Region: COG0517 652616006628 ribonuclease Z; Reviewed; Region: PRK00055 652616006629 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 652616006630 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 652616006631 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 652616006632 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 652616006633 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 652616006634 Uncharacterized conserved protein [Function unknown]; Region: COG2308 652616006635 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 652616006636 hypothetical protein; Reviewed; Region: PRK07914 652616006637 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 652616006638 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 652616006639 Competence protein; Region: Competence; pfam03772 652616006640 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 652616006641 Helix-hairpin-helix motif; Region: HHH; pfam00633 652616006642 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 652616006643 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 652616006644 Coenzyme A binding pocket [chemical binding]; other site 652616006645 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 652616006646 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 652616006647 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 652616006648 active site 652616006649 catalytic triad [active] 652616006650 oxyanion hole [active] 652616006651 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 652616006652 catalytic core [active] 652616006653 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 652616006654 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 652616006655 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 652616006656 active site 652616006657 (T/H)XGH motif; other site 652616006658 Methyltransferase domain; Region: Methyltransf_23; pfam13489 652616006659 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 652616006660 S-adenosylmethionine binding site [chemical binding]; other site 652616006661 Transposase; Region: DEDD_Tnp_IS110; pfam01548 652616006662 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 652616006663 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 652616006664 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 652616006665 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 652616006666 metal ion-dependent adhesion site (MIDAS); other site 652616006667 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 652616006668 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 652616006669 Walker A motif; other site 652616006670 ATP binding site [chemical binding]; other site 652616006671 Walker B motif; other site 652616006672 arginine finger; other site 652616006673 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 652616006674 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 652616006675 putative catalytic cysteine [active] 652616006676 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 652616006677 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 652616006678 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 652616006679 dimer interface [polypeptide binding]; other site 652616006680 decamer (pentamer of dimers) interface [polypeptide binding]; other site 652616006681 catalytic triad [active] 652616006682 peroxidatic and resolving cysteines [active] 652616006683 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 652616006684 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 652616006685 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616006686 PPE family; Region: PPE; pfam00823 652616006687 PE family; Region: PE; pfam00934 652616006688 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 652616006689 Mechanosensitive ion channel; Region: MS_channel; pfam00924 652616006690 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 652616006691 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 652616006692 ligand binding site [chemical binding]; other site 652616006693 flexible hinge region; other site 652616006694 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 652616006695 dimerization interface [polypeptide binding]; other site 652616006696 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 652616006697 cyclase homology domain; Region: CHD; cd07302 652616006698 nucleotidyl binding site; other site 652616006699 metal binding site [ion binding]; metal-binding site 652616006700 dimer interface [polypeptide binding]; other site 652616006701 alpha-dioxygenase; Region: PLN02283 652616006702 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 652616006703 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 652616006704 substrate binding site [chemical binding]; other site 652616006705 ATP binding site [chemical binding]; other site 652616006706 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 652616006707 NAD synthetase; Reviewed; Region: nadE; PRK02628 652616006708 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 652616006709 multimer interface [polypeptide binding]; other site 652616006710 active site 652616006711 catalytic triad [active] 652616006712 protein interface 1 [polypeptide binding]; other site 652616006713 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 652616006714 homodimer interface [polypeptide binding]; other site 652616006715 NAD binding pocket [chemical binding]; other site 652616006716 ATP binding pocket [chemical binding]; other site 652616006717 Mg binding site [ion binding]; other site 652616006718 active-site loop [active] 652616006719 glutamate 5-kinase; Region: proB; TIGR01027 652616006720 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 652616006721 nucleotide binding site [chemical binding]; other site 652616006722 homotetrameric interface [polypeptide binding]; other site 652616006723 putative phosphate binding site [ion binding]; other site 652616006724 putative allosteric binding site; other site 652616006725 PUA domain; Region: PUA; pfam01472 652616006726 GTPase CgtA; Reviewed; Region: obgE; PRK12296 652616006727 GTP1/OBG; Region: GTP1_OBG; pfam01018 652616006728 Obg GTPase; Region: Obg; cd01898 652616006729 G1 box; other site 652616006730 GTP/Mg2+ binding site [chemical binding]; other site 652616006731 Switch I region; other site 652616006732 G2 box; other site 652616006733 G3 box; other site 652616006734 Switch II region; other site 652616006735 G4 box; other site 652616006736 G5 box; other site 652616006737 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 652616006738 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 652616006739 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 652616006740 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 652616006741 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 652616006742 homodimer interface [polypeptide binding]; other site 652616006743 oligonucleotide binding site [chemical binding]; other site 652616006744 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 652616006745 active site 652616006746 multimer interface [polypeptide binding]; other site 652616006747 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 652616006748 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 652616006749 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 652616006750 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 652616006751 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 652616006752 active site 652616006753 HIGH motif; other site 652616006754 nucleotide binding site [chemical binding]; other site 652616006755 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 652616006756 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 652616006757 active site 652616006758 KMSKS motif; other site 652616006759 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 652616006760 tRNA binding surface [nucleotide binding]; other site 652616006761 anticodon binding site; other site 652616006762 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 652616006763 Uncharacterized conserved protein [Function unknown]; Region: COG3268 652616006764 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 652616006765 NAD(P) binding pocket [chemical binding]; other site 652616006766 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 652616006767 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 652616006768 GTP binding site; other site 652616006769 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 652616006770 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 652616006771 TPP-binding site [chemical binding]; other site 652616006772 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 652616006773 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 652616006774 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 652616006775 dimer interface [polypeptide binding]; other site 652616006776 PYR/PP interface [polypeptide binding]; other site 652616006777 TPP binding site [chemical binding]; other site 652616006778 substrate binding site [chemical binding]; other site 652616006779 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 652616006780 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 652616006781 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 652616006782 Walker A motif; other site 652616006783 ATP binding site [chemical binding]; other site 652616006784 Walker B motif; other site 652616006785 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 652616006786 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 652616006787 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 652616006788 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 652616006789 Major Facilitator Superfamily; Region: MFS_1; pfam07690 652616006790 putative substrate translocation pore; other site 652616006791 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 652616006792 Clp protease; Region: CLP_protease; pfam00574 652616006793 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 652616006794 oligomer interface [polypeptide binding]; other site 652616006795 active site residues [active] 652616006796 trigger factor; Provisional; Region: tig; PRK01490 652616006797 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 652616006798 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 652616006799 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 652616006800 Beta-lactamase; Region: Beta-lactamase; pfam00144 652616006801 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 652616006802 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 652616006803 putative DNA binding site [nucleotide binding]; other site 652616006804 catalytic residue [active] 652616006805 putative H2TH interface [polypeptide binding]; other site 652616006806 putative catalytic residues [active] 652616006807 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 652616006808 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 652616006809 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 652616006810 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 652616006811 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 652616006812 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 652616006813 Zn binding site [ion binding]; other site 652616006814 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 652616006815 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 652616006816 active site 652616006817 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 652616006818 apolar tunnel; other site 652616006819 heme binding site [chemical binding]; other site 652616006820 dimerization interface [polypeptide binding]; other site 652616006821 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 652616006822 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 652616006823 active site 652616006824 catalytic site [active] 652616006825 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 652616006826 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 652616006827 active site 652616006828 NAD-specific glutamate dehydrogenase [Amino acid transport and metabolism]; Region: COG2902 652616006829 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 652616006830 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 652616006831 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 652616006832 ABC transporter; Region: ABC_tran_2; pfam12848 652616006833 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 652616006834 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 652616006835 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 652616006836 dimer interface [polypeptide binding]; other site 652616006837 ssDNA binding site [nucleotide binding]; other site 652616006838 tetramer (dimer of dimers) interface [polypeptide binding]; other site 652616006839 glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355 652616006840 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 652616006841 putative acyl-acceptor binding pocket; other site 652616006842 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 652616006843 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 652616006844 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 652616006845 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 652616006846 putative acyl-acceptor binding pocket; other site 652616006847 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 652616006848 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 652616006849 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 652616006850 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 652616006851 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 652616006852 enoyl-CoA hydratase; Provisional; Region: PRK05870 652616006853 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 652616006854 substrate binding site [chemical binding]; other site 652616006855 oxyanion hole (OAH) forming residues; other site 652616006856 trimer interface [polypeptide binding]; other site 652616006857 PE family; Region: PE; pfam00934 652616006858 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 652616006859 cyclase homology domain; Region: CHD; cd07302 652616006860 nucleotidyl binding site; other site 652616006861 metal binding site [ion binding]; metal-binding site 652616006862 dimer interface [polypeptide binding]; other site 652616006863 Predicted ATPase [General function prediction only]; Region: COG3903 652616006864 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 652616006865 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 652616006866 DNA binding residues [nucleotide binding] 652616006867 dimerization interface [polypeptide binding]; other site 652616006868 TIGR00725 family protein; Region: TIGR00725 652616006869 thymidylate synthase; Provisional; Region: thyA; PRK00956 652616006870 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 652616006871 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 652616006872 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 652616006873 E3 interaction surface; other site 652616006874 lipoyl attachment site [posttranslational modification]; other site 652616006875 e3 binding domain; Region: E3_binding; pfam02817 652616006876 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 652616006877 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 652616006878 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 652616006879 alpha subunit interface [polypeptide binding]; other site 652616006880 TPP binding site [chemical binding]; other site 652616006881 heterodimer interface [polypeptide binding]; other site 652616006882 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 652616006883 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 652616006884 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 652616006885 tetramer interface [polypeptide binding]; other site 652616006886 TPP-binding site [chemical binding]; other site 652616006887 heterodimer interface [polypeptide binding]; other site 652616006888 phosphorylation loop region [posttranslational modification] 652616006889 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 652616006890 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 652616006891 putative active site [active] 652616006892 putative catalytic site [active] 652616006893 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 652616006894 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 652616006895 active site 652616006896 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 652616006897 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 652616006898 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 652616006899 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 652616006900 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 652616006901 carboxyltransferase (CT) interaction site; other site 652616006902 biotinylation site [posttranslational modification]; other site 652616006903 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 652616006904 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 652616006905 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 652616006906 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 652616006907 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 652616006908 AMP-binding domain protein; Validated; Region: PRK08315 652616006909 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 652616006910 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 652616006911 acyl-activating enzyme (AAE) consensus motif; other site 652616006912 acyl-activating enzyme (AAE) consensus motif; other site 652616006913 putative AMP binding site [chemical binding]; other site 652616006914 putative active site [active] 652616006915 putative CoA binding site [chemical binding]; other site 652616006916 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 652616006917 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 652616006918 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 652616006919 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 652616006920 classical (c) SDRs; Region: SDR_c; cd05233 652616006921 NAD(P) binding site [chemical binding]; other site 652616006922 active site 652616006923 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 652616006924 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 652616006925 catalytic site [active] 652616006926 putative active site [active] 652616006927 putative substrate binding site [chemical binding]; other site 652616006928 dimer interface [polypeptide binding]; other site 652616006929 Transposase, Mutator family; Region: Transposase_mut; pfam00872 652616006930 MULE transposase domain; Region: MULE; pfam10551 652616006931 Domain of unknown function (DUF4411); Region: DUF4411; pfam14367 652616006932 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 652616006933 non-specific DNA binding site [nucleotide binding]; other site 652616006934 salt bridge; other site 652616006935 sequence-specific DNA binding site [nucleotide binding]; other site 652616006936 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 652616006937 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893 652616006938 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 652616006939 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 652616006940 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 652616006941 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 652616006942 PE family; Region: PE; pfam00934 652616006943 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 652616006944 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 652616006945 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 652616006946 catalytic triad [active] 652616006947 hypothetical protein; Provisional; Region: PRK07907 652616006948 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 652616006949 active site 652616006950 metal binding site [ion binding]; metal-binding site 652616006951 dimer interface [polypeptide binding]; other site 652616006952 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 652616006953 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 652616006954 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 652616006955 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 652616006956 phosphate binding site [ion binding]; other site 652616006957 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 652616006958 FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447 652616006959 putative active site [active] 652616006960 putative catalytic site [active] 652616006961 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 652616006962 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 652616006963 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 652616006964 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 652616006965 putative NAD(P) binding site [chemical binding]; other site 652616006966 active site 652616006967 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 652616006968 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 652616006969 active site 652616006970 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 652616006971 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 652616006972 putative active site [active] 652616006973 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 652616006974 Mrr N-terminal domain; Region: Mrr_N; pfam14338 652616006975 Restriction endonuclease; Region: Mrr_cat; pfam04471 652616006976 Mrr N-terminal domain; Region: Mrr_N; pfam14338 652616006977 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 652616006978 ERCC4 domain; Region: ERCC4; pfam02732 652616006979 Lsr2; Region: Lsr2; pfam11774 652616006980 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 652616006981 putative active site [active] 652616006982 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 652616006983 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 652616006984 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 652616006985 catalytic residue [active] 652616006986 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 652616006987 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 652616006988 elongation factor P; Validated; Region: PRK00529 652616006989 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 652616006990 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 652616006991 RNA binding site [nucleotide binding]; other site 652616006992 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 652616006993 RNA binding site [nucleotide binding]; other site 652616006994 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 652616006995 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 652616006996 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 652616006997 active site 652616006998 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 652616006999 Dehydroquinase class II; Region: DHquinase_II; pfam01220 652616007000 trimer interface [polypeptide binding]; other site 652616007001 active site 652616007002 dimer interface [polypeptide binding]; other site 652616007003 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 652616007004 active site 652616007005 dimer interface [polypeptide binding]; other site 652616007006 metal binding site [ion binding]; metal-binding site 652616007007 shikimate kinase; Reviewed; Region: aroK; PRK00131 652616007008 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 652616007009 ADP binding site [chemical binding]; other site 652616007010 magnesium binding site [ion binding]; other site 652616007011 putative shikimate binding site; other site 652616007012 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 652616007013 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 652616007014 Tetramer interface [polypeptide binding]; other site 652616007015 active site 652616007016 FMN-binding site [chemical binding]; other site 652616007017 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 652616007018 digalactosyldiacylglycerol synthase; Region: PLN02846 652616007019 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 652616007020 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 652616007021 putative active site [active] 652616007022 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 652616007023 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 652616007024 oligomeric interface; other site 652616007025 putative active site [active] 652616007026 homodimer interface [polypeptide binding]; other site 652616007027 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402 652616007028 putative active site [active] 652616007029 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 652616007030 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 652616007031 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 652616007032 shikimate-5-dehydrogenase, fungal AROM-type; Region: Shik-DH-AROM; TIGR01809 652616007033 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 652616007034 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 652616007035 NAD(P) binding site [chemical binding]; other site 652616007036 shikimate binding site; other site 652616007037 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 652616007038 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 652616007039 dimerization interface [polypeptide binding]; other site 652616007040 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 652616007041 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 652616007042 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 652616007043 motif 1; other site 652616007044 active site 652616007045 motif 2; other site 652616007046 motif 3; other site 652616007047 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 652616007048 DHHA1 domain; Region: DHHA1; pfam02272 652616007049 Uncharacterized conserved protein [Function unknown]; Region: COG0432 652616007050 recombination factor protein RarA; Reviewed; Region: PRK13342 652616007051 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 652616007052 Walker A motif; other site 652616007053 ATP binding site [chemical binding]; other site 652616007054 Walker B motif; other site 652616007055 arginine finger; other site 652616007056 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 652616007057 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 652616007058 Protein of unknown function (DUF2652); Region: DUF2652; pfam10851 652616007059 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 652616007060 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 652616007061 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 652616007062 Walker A/P-loop; other site 652616007063 ATP binding site [chemical binding]; other site 652616007064 Q-loop/lid; other site 652616007065 ABC transporter signature motif; other site 652616007066 Walker B; other site 652616007067 D-loop; other site 652616007068 H-loop/switch region; other site 652616007069 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 652616007070 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 652616007071 ligand binding site [chemical binding]; other site 652616007072 flexible hinge region; other site 652616007073 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 652616007074 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 652616007075 ligand binding site [chemical binding]; other site 652616007076 flexible hinge region; other site 652616007077 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 652616007078 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 652616007079 active site 652616007080 nucleophile elbow; other site 652616007081 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 652616007082 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 652616007083 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 652616007084 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 652616007085 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 652616007086 Uncharacterized conserved protein [Function unknown]; Region: COG2308 652616007087 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 652616007088 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 652616007089 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 652616007090 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 652616007091 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 652616007092 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 652616007093 Transglutaminase/protease-like homologues; Region: TGc; smart00460 652616007094 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3801 652616007095 Predicted membrane protein [Function unknown]; Region: COG4129 652616007096 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 652616007097 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 652616007098 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 652616007099 dimer interface [polypeptide binding]; other site 652616007100 anticodon binding site; other site 652616007101 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 652616007102 homodimer interface [polypeptide binding]; other site 652616007103 motif 1; other site 652616007104 active site 652616007105 motif 2; other site 652616007106 GAD domain; Region: GAD; pfam02938 652616007107 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 652616007108 active site 652616007109 motif 3; other site 652616007110 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 652616007111 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 652616007112 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 652616007113 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 652616007114 putative hydrophobic ligand binding site [chemical binding]; other site 652616007115 protein interface [polypeptide binding]; other site 652616007116 gate; other site 652616007117 Predicted metalloprotease [General function prediction only]; Region: COG2321 652616007118 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 652616007119 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 652616007120 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 652616007121 active site 652616007122 metal binding site [ion binding]; metal-binding site 652616007123 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 652616007124 haloalkane dehalogenase; Provisional; Region: PRK03592 652616007125 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 652616007126 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 652616007127 dimer interface [polypeptide binding]; other site 652616007128 motif 1; other site 652616007129 active site 652616007130 motif 2; other site 652616007131 motif 3; other site 652616007132 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 652616007133 anticodon binding site; other site 652616007134 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 652616007135 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 652616007136 active site 652616007137 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 652616007138 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 652616007139 Zn2+ binding site [ion binding]; other site 652616007140 Mg2+ binding site [ion binding]; other site 652616007141 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 652616007142 synthetase active site [active] 652616007143 NTP binding site [chemical binding]; other site 652616007144 metal binding site [ion binding]; metal-binding site 652616007145 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 652616007146 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 652616007147 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 652616007148 active site 652616007149 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 652616007150 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 652616007151 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 652616007152 Protein export membrane protein; Region: SecD_SecF; pfam02355 652616007153 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 652616007154 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 652616007155 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05886 652616007156 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 652616007157 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 652616007158 inhibitor-cofactor binding pocket; inhibition site 652616007159 pyridoxal 5'-phosphate binding site [chemical binding]; other site 652616007160 catalytic residue [active] 652616007161 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 652616007162 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 652616007163 acyl-activating enzyme (AAE) consensus motif; other site 652616007164 AMP binding site [chemical binding]; other site 652616007165 active site 652616007166 CoA binding site [chemical binding]; other site 652616007167 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 652616007168 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 652616007169 putative NAD(P) binding site [chemical binding]; other site 652616007170 active site 652616007171 putative substrate binding site [chemical binding]; other site 652616007172 PE family; Region: PE; pfam00934 652616007173 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 652616007174 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 652616007175 Walker A motif; other site 652616007176 ATP binding site [chemical binding]; other site 652616007177 Walker B motif; other site 652616007178 arginine finger; other site 652616007179 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 652616007180 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 652616007181 RuvA N terminal domain; Region: RuvA_N; pfam01330 652616007182 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 652616007183 active site 652616007184 putative DNA-binding cleft [nucleotide binding]; other site 652616007185 dimer interface [polypeptide binding]; other site 652616007186 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 652616007187 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 652616007188 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 652616007189 putative active site [active] 652616007190 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 652616007191 Protein of unknown function DUF2617; Region: DUF2617; pfam10936 652616007192 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 652616007193 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 652616007194 Spermine/spermidine synthase; Region: Spermine_synth; pfam01564 652616007195 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 652616007196 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 652616007197 hypothetical protein; Validated; Region: PRK00110 652616007198 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 652616007199 predicted active site [active] 652616007200 catalytic triad [active] 652616007201 acyl-CoA thioesterase II; Region: tesB; TIGR00189 652616007202 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 652616007203 active site 652616007204 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 652616007205 catalytic triad [active] 652616007206 dimer interface [polypeptide binding]; other site 652616007207 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 652616007208 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 652616007209 active site 652616007210 multimer interface [polypeptide binding]; other site 652616007211 Pyridoxamine-phosphate oxidase [Coenzyme metabolism]; Region: PdxH; COG0259 652616007212 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 652616007213 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 652616007214 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616007215 PPE family; Region: PPE; pfam00823 652616007216 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616007217 PE-PPE domain; Region: PE-PPE; pfam08237 652616007218 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 652616007219 nudix motif; other site 652616007220 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 652616007221 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 652616007222 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 652616007223 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 652616007224 putative acyl-acceptor binding pocket; other site 652616007225 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 652616007226 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 652616007227 nucleotide binding site/active site [active] 652616007228 HIT family signature motif; other site 652616007229 catalytic residue [active] 652616007230 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 652616007231 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 652616007232 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 652616007233 active site 652616007234 dimer interface [polypeptide binding]; other site 652616007235 motif 1; other site 652616007236 motif 2; other site 652616007237 motif 3; other site 652616007238 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 652616007239 anticodon binding site; other site 652616007240 PE family; Region: PE; pfam00934 652616007241 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4762 652616007242 Helix-turn-helix domain; Region: HTH_20; pfam12840 652616007243 Predicted transcriptional regulator [Transcription]; Region: COG2345 652616007244 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 652616007245 Predicted transcriptional regulator [Transcription]; Region: COG2345 652616007246 Helix-turn-helix domain; Region: HTH_20; pfam12840 652616007247 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 652616007248 S-adenosylmethionine binding site [chemical binding]; other site 652616007249 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 652616007250 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 652616007251 Ligand Binding Site [chemical binding]; other site 652616007252 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 652616007253 Ligand Binding Site [chemical binding]; other site 652616007254 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 652616007255 Ligand Binding Site [chemical binding]; other site 652616007256 Universal stress protein family; Region: Usp; pfam00582 652616007257 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 652616007258 active site 652616007259 Peptidase family M50; Region: Peptidase_M50; pfam02163 652616007260 putative substrate binding region [chemical binding]; other site 652616007261 FOG: CBS domain [General function prediction only]; Region: COG0517 652616007262 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 652616007263 FOG: CBS domain [General function prediction only]; Region: COG0517 652616007264 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 652616007265 peptide chain release factor 1; Provisional; Region: PRK04011 652616007266 Archease protein family (MTH1598/TM1083); Region: Archease; cl00606 652616007267 Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690 652616007268 hypothetical protein; Reviewed; Region: PRK09588 652616007269 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 652616007270 Hemerythrin-like domain; Region: Hr-like; cd12108 652616007271 Fe binding site [ion binding]; other site 652616007272 PE family; Region: PE; pfam00934 652616007273 Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cd00227 652616007274 P-loop motif; other site 652616007275 ATP binding site [chemical binding]; other site 652616007276 Chloramphenicol (Cm) binding site [chemical binding]; other site 652616007277 catalytic residue [active] 652616007278 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 652616007279 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 652616007280 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 652616007281 anti sigma factor interaction site; other site 652616007282 regulatory phosphorylation site [posttranslational modification]; other site 652616007283 hypothetical protein; Provisional; Region: PRK02237 652616007284 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 652616007285 Transcriptional regulators [Transcription]; Region: MarR; COG1846 652616007286 putative DNA binding site [nucleotide binding]; other site 652616007287 putative Zn2+ binding site [ion binding]; other site 652616007288 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 652616007289 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 652616007290 putative metal binding site [ion binding]; other site 652616007291 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 652616007292 dimerization interface [polypeptide binding]; other site 652616007293 putative DNA binding site [nucleotide binding]; other site 652616007294 putative Zn2+ binding site [ion binding]; other site 652616007295 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 652616007296 arsenical-resistance protein; Region: acr3; TIGR00832 652616007297 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 652616007298 Low molecular weight phosphatase family; Region: LMWPc; cd00115 652616007299 active site 652616007300 Protein of unknown function (DUF3018); Region: DUF3018; pfam11455 652616007301 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 652616007302 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 652616007303 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 652616007304 active site 652616007305 DNA binding site [nucleotide binding] 652616007306 Int/Topo IB signature motif; other site 652616007307 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 652616007308 ParB-like nuclease domain; Region: ParBc; cl02129 652616007309 Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653 652616007310 Phage capsid family; Region: Phage_capsid; pfam05065 652616007311 phage prohead protease, HK97 family; Region: proheadase_HK97; TIGR01543 652616007312 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: COG3747 652616007313 Protein of unknown function (DUF3631); Region: DUF3631; pfam12307 652616007314 Protein of unknown function (DUF2742); Region: DUF2742; pfam10888 652616007315 DNA binding domain, excisionase family; Region: excise; TIGR01764 652616007316 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 652616007317 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 652616007318 active site 652616007319 catalytic residues [active] 652616007320 DNA binding site [nucleotide binding] 652616007321 Int/Topo IB signature motif; other site 652616007322 Transposase, Mutator family; Region: Transposase_mut; pfam00872 652616007323 MULE transposase domain; Region: MULE; pfam10551 652616007324 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 652616007325 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 652616007326 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 652616007327 Coenzyme A binding pocket [chemical binding]; other site 652616007328 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 652616007329 hypothetical protein; Provisional; Region: PRK14059 652616007330 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 652616007331 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 652616007332 TAP-like protein; Region: Abhydrolase_4; pfam08386 652616007333 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 652616007334 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 652616007335 SelR domain; Region: SelR; pfam01641 652616007336 Methyltransferase domain; Region: Methyltransf_31; pfam13847 652616007337 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 652616007338 S-adenosylmethionine binding site [chemical binding]; other site 652616007339 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 652616007340 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 652616007341 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 652616007342 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 652616007343 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 652616007344 substrate binding site [chemical binding]; other site 652616007345 active site 652616007346 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 652616007347 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 652616007348 substrate binding site [chemical binding]; other site 652616007349 oxyanion hole (OAH) forming residues; other site 652616007350 trimer interface [polypeptide binding]; other site 652616007351 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 652616007352 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 652616007353 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 652616007354 catalytic site [active] 652616007355 putative active site [active] 652616007356 putative substrate binding site [chemical binding]; other site 652616007357 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 652616007358 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 652616007359 TPP-binding site; other site 652616007360 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 652616007361 PYR/PP interface [polypeptide binding]; other site 652616007362 dimer interface [polypeptide binding]; other site 652616007363 TPP binding site [chemical binding]; other site 652616007364 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 652616007365 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 652616007366 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 652616007367 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 652616007368 transmembrane helices; other site 652616007369 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 652616007370 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 652616007371 transmembrane helices; other site 652616007372 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 652616007373 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 652616007374 Walker A/P-loop; other site 652616007375 ATP binding site [chemical binding]; other site 652616007376 Q-loop/lid; other site 652616007377 ABC transporter signature motif; other site 652616007378 Walker B; other site 652616007379 D-loop; other site 652616007380 H-loop/switch region; other site 652616007381 TRAM domain; Region: TRAM; cl01282 652616007382 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 652616007383 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 652616007384 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 652616007385 TrkA-N domain; Region: TrkA_N; pfam02254 652616007386 TrkA-C domain; Region: TrkA_C; pfam02080 652616007387 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 652616007388 TrkA-N domain; Region: TrkA_N; pfam02254 652616007389 TrkA-C domain; Region: TrkA_C; pfam02080 652616007390 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 652616007391 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 652616007392 generic binding surface II; other site 652616007393 ssDNA binding site; other site 652616007394 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 652616007395 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 652616007396 trimer interface [polypeptide binding]; other site 652616007397 active site 652616007398 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 652616007399 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 652616007400 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 652616007401 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 652616007402 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 652616007403 active site 652616007404 dimerization interface [polypeptide binding]; other site 652616007405 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 652616007406 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 652616007407 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 652616007408 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 652616007409 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 652616007410 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 652616007411 DNA binding residues [nucleotide binding] 652616007412 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 652616007413 homotrimer interaction site [polypeptide binding]; other site 652616007414 putative active site [active] 652616007415 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 652616007416 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 652616007417 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 652616007418 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 652616007419 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 652616007420 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 652616007421 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 652616007422 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 652616007423 DNA binding residues [nucleotide binding] 652616007424 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 652616007425 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 652616007426 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 652616007427 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 652616007428 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 652616007429 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 652616007430 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 652616007431 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 652616007432 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 652616007433 PAC2 family; Region: PAC2; pfam09754 652616007434 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 652616007435 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 652616007436 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 652616007437 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 652616007438 heme-binding site [chemical binding]; other site 652616007439 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 652616007440 ATP cone domain; Region: ATP-cone; pfam03477 652616007441 LysM domain; Region: LysM; pfam01476 652616007442 LexA repressor; Validated; Region: PRK00215 652616007443 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 652616007444 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 652616007445 Catalytic site [active] 652616007446 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 652616007447 LGFP repeat; Region: LGFP; pfam08310 652616007448 LGFP repeat; Region: LGFP; pfam08310 652616007449 LGFP repeat; Region: LGFP; pfam08310 652616007450 LGFP repeat; Region: LGFP; pfam08310 652616007451 LGFP repeat; Region: LGFP; pfam08310 652616007452 Integral membrane protein TerC family; Region: TerC; cl10468 652616007453 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 652616007454 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 652616007455 active site 652616007456 GTPases [General function prediction only]; Region: HflX; COG2262 652616007457 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 652616007458 HflX GTPase family; Region: HflX; cd01878 652616007459 G1 box; other site 652616007460 GTP/Mg2+ binding site [chemical binding]; other site 652616007461 Switch I region; other site 652616007462 G2 box; other site 652616007463 G3 box; other site 652616007464 Switch II region; other site 652616007465 G4 box; other site 652616007466 G5 box; other site 652616007467 diaminopimelate epimerase; Region: DapF; TIGR00652 652616007468 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 652616007469 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 652616007470 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 652616007471 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 652616007472 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 652616007473 active site 652616007474 metal binding site [ion binding]; metal-binding site 652616007475 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 652616007476 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 652616007477 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 652616007478 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 652616007479 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 652616007480 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 652616007481 FeS/SAM binding site; other site 652616007482 TRAM domain; Region: TRAM; cl01282 652616007483 Uncharacterized protein conserved in bacteria [General function prediction only]; Region: OraA; COG2137 652616007484 DNA recombination protein RecA; Reviewed; Region: recA; PRK09519 652616007485 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 652616007486 hexamer interface [polypeptide binding]; other site 652616007487 Walker A motif; other site 652616007488 ATP binding site [chemical binding]; other site 652616007489 Walker B motif; other site 652616007490 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 652616007491 protein-splicing catalytic site; other site 652616007492 thioester formation/cholesterol transfer; other site 652616007493 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 652616007494 recA bacterial DNA recombination protein; Region: RecA; cl17211 652616007495 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 652616007496 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 652616007497 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 652616007498 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 652616007499 Limonene-1,2-epoxide hydrolase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LimA; COG4308 652616007500 PE family; Region: PE; pfam00934 652616007501 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 652616007502 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 652616007503 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 652616007504 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 652616007505 non-specific DNA binding site [nucleotide binding]; other site 652616007506 salt bridge; other site 652616007507 sequence-specific DNA binding site [nucleotide binding]; other site 652616007508 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 652616007509 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 652616007510 Coenzyme A binding pocket [chemical binding]; other site 652616007511 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 652616007512 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 652616007513 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 652616007514 Uncharacterized conserved protein [Function unknown]; Region: COG1359 652616007515 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 652616007516 classical (c) SDRs; Region: SDR_c; cd05233 652616007517 NAD(P) binding site [chemical binding]; other site 652616007518 active site 652616007519 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 652616007520 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 652616007521 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 652616007522 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 652616007523 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 652616007524 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 652616007525 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 652616007526 dimer interface [polypeptide binding]; other site 652616007527 active site 652616007528 catalytic residue [active] 652616007529 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 652616007530 HsdM N-terminal domain; Region: HsdM_N; pfam12161 652616007531 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 652616007532 Methyltransferase domain; Region: Methyltransf_26; pfam13659 652616007533 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 652616007534 putative active site [active] 652616007535 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 652616007536 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 652616007537 putative active site [active] 652616007538 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 652616007539 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 652616007540 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 652616007541 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 652616007542 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 652616007543 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 652616007544 folate binding site [chemical binding]; other site 652616007545 NADP+ binding site [chemical binding]; other site 652616007546 thymidylate synthase; Reviewed; Region: thyA; PRK01827 652616007547 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 652616007548 dimerization interface [polypeptide binding]; other site 652616007549 active site 652616007550 Dienelactone hydrolase family; Region: DLH; pfam01738 652616007551 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 652616007552 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 652616007553 classical (c) SDRs; Region: SDR_c; cd05233 652616007554 NAD(P) binding site [chemical binding]; other site 652616007555 active site 652616007556 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616007557 PPE family; Region: PPE; pfam00823 652616007558 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 652616007559 PE family; Region: PE; pfam00934 652616007560 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 652616007561 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616007562 PPE family; Region: PPE; pfam00823 652616007563 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 652616007564 dihydrodipicolinate reductase; Provisional; Region: PRK00048 652616007565 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 652616007566 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 652616007567 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 652616007568 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 652616007569 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 652616007570 Coenzyme A binding pocket [chemical binding]; other site 652616007571 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 652616007572 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 652616007573 FMN-binding pocket [chemical binding]; other site 652616007574 flavin binding motif; other site 652616007575 phosphate binding motif [ion binding]; other site 652616007576 beta-alpha-beta structure motif; other site 652616007577 NAD binding pocket [chemical binding]; other site 652616007578 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 652616007579 catalytic loop [active] 652616007580 iron binding site [ion binding]; other site 652616007581 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 652616007582 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 652616007583 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 652616007584 hydrophobic ligand binding site; other site 652616007585 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 652616007586 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 652616007587 putative DNA binding site [nucleotide binding]; other site 652616007588 putative Zn2+ binding site [ion binding]; other site 652616007589 AsnC family; Region: AsnC_trans_reg; pfam01037 652616007590 alanine dehydrogenase; Region: alaDH; TIGR00518 652616007591 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 652616007592 hexamer interface [polypeptide binding]; other site 652616007593 ligand binding site [chemical binding]; other site 652616007594 putative active site [active] 652616007595 NAD(P) binding site [chemical binding]; other site 652616007596 Nitronate monooxygenase; Region: NMO; pfam03060 652616007597 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 652616007598 FMN binding site [chemical binding]; other site 652616007599 substrate binding site [chemical binding]; other site 652616007600 putative catalytic residue [active] 652616007601 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 652616007602 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 652616007603 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 652616007604 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 652616007605 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 652616007606 oligomer interface [polypeptide binding]; other site 652616007607 RNA binding site [nucleotide binding]; other site 652616007608 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 652616007609 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 652616007610 RNase E interface [polypeptide binding]; other site 652616007611 trimer interface [polypeptide binding]; other site 652616007612 active site 652616007613 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 652616007614 putative nucleic acid binding region [nucleotide binding]; other site 652616007615 G-X-X-G motif; other site 652616007616 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 652616007617 RNA binding site [nucleotide binding]; other site 652616007618 domain interface; other site 652616007619 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 652616007620 16S/18S rRNA binding site [nucleotide binding]; other site 652616007621 S13e-L30e interaction site [polypeptide binding]; other site 652616007622 25S rRNA binding site [nucleotide binding]; other site 652616007623 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 652616007624 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 652616007625 active site 652616007626 Riboflavin kinase; Region: Flavokinase; pfam01687 652616007627 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 652616007628 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 652616007629 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 652616007630 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 652616007631 putative DNA binding site [nucleotide binding]; other site 652616007632 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 652616007633 FeoA domain; Region: FeoA; pfam04023 652616007634 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 652616007635 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 652616007636 active site 652616007637 lipid-transfer protein; Provisional; Region: PRK08256 652616007638 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 652616007639 active site 652616007640 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 652616007641 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 652616007642 Probable transposase; Region: OrfB_IS605; pfam01385 652616007643 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 652616007644 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 652616007645 catalytic residues [active] 652616007646 catalytic nucleophile [active] 652616007647 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 652616007648 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 652616007649 RNA binding site [nucleotide binding]; other site 652616007650 active site 652616007651 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 652616007652 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 652616007653 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 652616007654 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 652616007655 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 652616007656 active site 652616007657 metal binding site [ion binding]; metal-binding site 652616007658 Uncharacterized conserved protein [Function unknown]; Region: COG4717 652616007659 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 652616007660 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 652616007661 Predicted acyl esterases [General function prediction only]; Region: COG2936 652616007662 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 652616007663 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 652616007664 Uncharacterized conserved protein [Function unknown]; Region: COG5586 652616007665 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 652616007666 Integrase core domain; Region: rve; pfam00665 652616007667 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 652616007668 Transposase; Region: DDE_Tnp_ISL3; pfam01610 652616007669 Helix-turn-helix domain; Region: HTH_28; pfam13518 652616007670 Winged helix-turn helix; Region: HTH_29; pfam13551 652616007671 Integrase core domain; Region: rve; pfam00665 652616007672 Integrase core domain; Region: rve_3; pfam13683 652616007673 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 652616007674 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 652616007675 putative transposase OrfB; Reviewed; Region: PHA02517 652616007676 HTH-like domain; Region: HTH_21; pfam13276 652616007677 Integrase core domain; Region: rve; pfam00665 652616007678 Integrase core domain; Region: rve_3; pfam13683 652616007679 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 652616007680 Transposase; Region: HTH_Tnp_1; cl17663 652616007681 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 652616007682 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09636 652616007683 putative transposase OrfB; Reviewed; Region: PHA02517 652616007684 HTH-like domain; Region: HTH_21; pfam13276 652616007685 Integrase core domain; Region: rve; pfam00665 652616007686 Integrase core domain; Region: rve_3; pfam13683 652616007687 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl09873 652616007688 CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cl17437 652616007689 putative transposase OrfB; Reviewed; Region: PHA02517 652616007690 HTH-like domain; Region: HTH_21; pfam13276 652616007691 Integrase core domain; Region: rve; pfam00665 652616007692 Integrase core domain; Region: rve_3; pfam13683 652616007693 CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cd09662 652616007694 CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cd09663 652616007695 CRISPR/Cas system-associated RAMP superfamily protein Csm3; Region: Csm3_III-A; cd09684 652616007696 CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cd09647 652616007697 Predicted CRISPR-associated polymerase [Defense mechanisms]; Region: COG1353 652616007698 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 652616007699 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 652616007700 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4293 652616007701 Uncharacterized conserved protein [Function unknown]; Region: COG2253 652616007702 Protein of unknown function (DUF2005); Region: DUF2005; pfam09407 652616007703 Domain of unknown function (DUF1802); Region: DUF1802; cl01755 652616007704 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 652616007705 putative active site [active] 652616007706 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 652616007707 enoyl-CoA hydratase; Provisional; Region: PRK06190 652616007708 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 652616007709 substrate binding site [chemical binding]; other site 652616007710 oxyanion hole (OAH) forming residues; other site 652616007711 trimer interface [polypeptide binding]; other site 652616007712 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 652616007713 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 652616007714 Walker A/P-loop; other site 652616007715 ATP binding site [chemical binding]; other site 652616007716 Q-loop/lid; other site 652616007717 ABC transporter signature motif; other site 652616007718 Walker B; other site 652616007719 D-loop; other site 652616007720 H-loop/switch region; other site 652616007721 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 652616007722 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 652616007723 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 652616007724 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 652616007725 dimer interface [polypeptide binding]; other site 652616007726 conserved gate region; other site 652616007727 putative PBP binding loops; other site 652616007728 ABC-ATPase subunit interface; other site 652616007729 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 652616007730 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 652616007731 dimer interface [polypeptide binding]; other site 652616007732 conserved gate region; other site 652616007733 putative PBP binding loops; other site 652616007734 ABC-ATPase subunit interface; other site 652616007735 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 652616007736 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 652616007737 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 652616007738 DHH family; Region: DHH; pfam01368 652616007739 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 652616007740 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 652616007741 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 652616007742 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 652616007743 G1 box; other site 652616007744 putative GEF interaction site [polypeptide binding]; other site 652616007745 GTP/Mg2+ binding site [chemical binding]; other site 652616007746 Switch I region; other site 652616007747 G2 box; other site 652616007748 G3 box; other site 652616007749 Switch II region; other site 652616007750 G4 box; other site 652616007751 G5 box; other site 652616007752 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 652616007753 Translation-initiation factor 2; Region: IF-2; pfam11987 652616007754 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 652616007755 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189 652616007756 putative RNA binding cleft [nucleotide binding]; other site 652616007757 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 652616007758 NusA N-terminal domain; Region: NusA_N; pfam08529 652616007759 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 652616007760 RNA binding site [nucleotide binding]; other site 652616007761 homodimer interface [polypeptide binding]; other site 652616007762 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 652616007763 G-X-X-G motif; other site 652616007764 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 652616007765 G-X-X-G motif; other site 652616007766 ribosome maturation protein RimP; Reviewed; Region: PRK00092 652616007767 Sm and related proteins; Region: Sm_like; cl00259 652616007768 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 652616007769 putative oligomer interface [polypeptide binding]; other site 652616007770 putative RNA binding site [nucleotide binding]; other site 652616007771 Mitochondrial ATP synthase g subunit; Region: ATP-synt_G; pfam04718 652616007772 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 652616007773 dinuclear metal binding motif [ion binding]; other site 652616007774 prolyl-tRNA synthetase; Provisional; Region: PRK09194 652616007775 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 652616007776 dimer interface [polypeptide binding]; other site 652616007777 motif 1; other site 652616007778 active site 652616007779 motif 2; other site 652616007780 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 652616007781 putative deacylase active site [active] 652616007782 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 652616007783 active site 652616007784 motif 3; other site 652616007785 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 652616007786 anticodon binding site; other site 652616007787 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 652616007788 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 652616007789 putative substrate translocation pore; other site 652616007790 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 652616007791 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 652616007792 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 652616007793 homodimer interface [polypeptide binding]; other site 652616007794 active site 652616007795 SAM binding site [chemical binding]; other site 652616007796 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 652616007797 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 652616007798 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 652616007799 catalytic triad [active] 652616007800 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 652616007801 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 652616007802 homodimer interface [polypeptide binding]; other site 652616007803 Walker A motif; other site 652616007804 ATP binding site [chemical binding]; other site 652616007805 hydroxycobalamin binding site [chemical binding]; other site 652616007806 Walker B motif; other site 652616007807 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 652616007808 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 652616007809 Walker A motif; other site 652616007810 ATP binding site [chemical binding]; other site 652616007811 Walker B motif; other site 652616007812 arginine finger; other site 652616007813 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 652616007814 metal ion-dependent adhesion site (MIDAS); other site 652616007815 Predicted acyltransferase [General function prediction only]; Region: ElaA; COG2153 652616007816 malate:quinone oxidoreductase; Validated; Region: PRK05257 652616007817 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 652616007818 PE family; Region: PE; pfam00934 652616007819 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 652616007820 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 652616007821 mycothione reductase; Reviewed; Region: PRK07846 652616007822 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 652616007823 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 652616007824 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 652616007825 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 652616007826 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 652616007827 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 652616007828 short chain dehydrogenase; Provisional; Region: PRK06057 652616007829 classical (c) SDRs; Region: SDR_c; cd05233 652616007830 NAD(P) binding site [chemical binding]; other site 652616007831 active site 652616007832 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 652616007833 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 652616007834 NAD(P) binding site [chemical binding]; other site 652616007835 catalytic residues [active] 652616007836 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 652616007837 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 652616007838 catalytic triad [active] 652616007839 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 652616007840 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 652616007841 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 652616007842 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 652616007843 active site 652616007844 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 652616007845 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 652616007846 putative active site [active] 652616007847 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 652616007848 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 652616007849 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 652616007850 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 652616007851 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 652616007852 Predicted acetyltransferase [General function prediction only]; Region: COG3393 652616007853 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 652616007854 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 652616007855 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 652616007856 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 652616007857 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 652616007858 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 652616007859 active site 652616007860 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 652616007861 protein binding site [polypeptide binding]; other site 652616007862 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 652616007863 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 652616007864 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 652616007865 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 652616007866 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 652616007867 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 652616007868 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 652616007869 Fasciclin domain; Region: Fasciclin; pfam02469 652616007870 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 652616007871 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 652616007872 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 652616007873 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 652616007874 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 652616007875 catalytic residues [active] 652616007876 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 652616007877 Fasciclin domain; Region: Fasciclin; pfam02469 652616007878 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 652616007879 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 652616007880 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 652616007881 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 652616007882 catalytic residues [active] 652616007883 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 652616007884 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 652616007885 FeS/SAM binding site; other site 652616007886 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 652616007887 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 652616007888 ribosome recycling factor; Reviewed; Region: frr; PRK00083 652616007889 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 652616007890 hinge region; other site 652616007891 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 652616007892 putative nucleotide binding site [chemical binding]; other site 652616007893 uridine monophosphate binding site [chemical binding]; other site 652616007894 homohexameric interface [polypeptide binding]; other site 652616007895 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 652616007896 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 652616007897 DNA binding site [nucleotide binding] 652616007898 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 652616007899 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 652616007900 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 652616007901 Probable transposase; Region: OrfB_IS605; pfam01385 652616007902 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 652616007903 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 652616007904 catalytic residues [active] 652616007905 catalytic nucleophile [active] 652616007906 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 652616007907 MarR family; Region: MarR; pfam01047 652616007908 amidase; Provisional; Region: PRK07869 652616007909 Amidase; Region: Amidase; pfam01425 652616007910 elongation factor Ts; Provisional; Region: tsf; PRK09377 652616007911 UBA/TS-N domain; Region: UBA; pfam00627 652616007912 Elongation factor TS; Region: EF_TS; pfam00889 652616007913 Elongation factor TS; Region: EF_TS; pfam00889 652616007914 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 652616007915 rRNA interaction site [nucleotide binding]; other site 652616007916 S8 interaction site; other site 652616007917 putative laminin-1 binding site; other site 652616007918 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616007919 PPE family; Region: PPE; pfam00823 652616007920 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 652616007921 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 652616007922 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 652616007923 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 652616007924 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 652616007925 active site 652616007926 DNA binding site [nucleotide binding] 652616007927 Int/Topo IB signature motif; other site 652616007928 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 652616007929 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 652616007930 FAD binding pocket [chemical binding]; other site 652616007931 FAD binding motif [chemical binding]; other site 652616007932 phosphate binding motif [ion binding]; other site 652616007933 NAD binding pocket [chemical binding]; other site 652616007934 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 652616007935 DNA protecting protein DprA; Region: dprA; TIGR00732 652616007936 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 652616007937 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 652616007938 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 652616007939 Walker A motif; other site 652616007940 ATP binding site [chemical binding]; other site 652616007941 Walker B motif; other site 652616007942 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 652616007943 hypothetical protein; Reviewed; Region: PRK12497 652616007944 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 652616007945 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 652616007946 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 652616007947 putative molybdopterin cofactor binding site [chemical binding]; other site 652616007948 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 652616007949 putative molybdopterin cofactor binding site; other site 652616007950 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 652616007951 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 652616007952 RNA/DNA hybrid binding site [nucleotide binding]; other site 652616007953 active site 652616007954 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 652616007955 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 652616007956 Catalytic site [active] 652616007957 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 652616007958 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 652616007959 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 652616007960 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 652616007961 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 652616007962 RimM N-terminal domain; Region: RimM; pfam01782 652616007963 hypothetical protein; Provisional; Region: PRK02821 652616007964 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 652616007965 G-X-X-G motif; other site 652616007966 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 652616007967 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 652616007968 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 652616007969 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 652616007970 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 652616007971 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 652616007972 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 652616007973 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 652616007974 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 652616007975 Catalytic domain of Protein Kinases; Region: PKc; cd00180 652616007976 active site 652616007977 ATP binding site [chemical binding]; other site 652616007978 substrate binding site [chemical binding]; other site 652616007979 activation loop (A-loop); other site 652616007980 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 652616007981 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 652616007982 active site 652616007983 signal recognition particle protein; Provisional; Region: PRK10867 652616007984 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 652616007985 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 652616007986 P loop; other site 652616007987 GTP binding site [chemical binding]; other site 652616007988 Signal peptide binding domain; Region: SRP_SPB; pfam02978 652616007989 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 652616007990 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 652616007991 ATP binding site [chemical binding]; other site 652616007992 putative Mg++ binding site [ion binding]; other site 652616007993 PII uridylyl-transferase; Provisional; Region: PRK03381 652616007994 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 652616007995 metal binding triad; other site 652616007996 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 652616007997 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 652616007998 Zn2+ binding site [ion binding]; other site 652616007999 Mg2+ binding site [ion binding]; other site 652616008000 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 652616008001 Nitrogen regulatory protein P-II; Region: P-II; smart00938 652616008002 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 652616008003 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 652616008004 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 652616008005 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 652616008006 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 652616008007 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 652616008008 Walker A/P-loop; other site 652616008009 ATP binding site [chemical binding]; other site 652616008010 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 652616008011 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 652616008012 ABC transporter signature motif; other site 652616008013 Walker B; other site 652616008014 D-loop; other site 652616008015 H-loop/switch region; other site 652616008016 acylphosphatase; Provisional; Region: PRK14422 652616008017 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 652616008018 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 652616008019 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 652616008020 DNA binding site [nucleotide binding] 652616008021 catalytic residue [active] 652616008022 H2TH interface [polypeptide binding]; other site 652616008023 putative catalytic residues [active] 652616008024 turnover-facilitating residue; other site 652616008025 intercalation triad [nucleotide binding]; other site 652616008026 8OG recognition residue [nucleotide binding]; other site 652616008027 putative reading head residues; other site 652616008028 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 652616008029 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 652616008030 ribonuclease III; Reviewed; Region: rnc; PRK00102 652616008031 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 652616008032 dimerization interface [polypeptide binding]; other site 652616008033 active site 652616008034 metal binding site [ion binding]; metal-binding site 652616008035 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 652616008036 dsRNA binding site [nucleotide binding]; other site 652616008037 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 652616008038 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 652616008039 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 652616008040 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 652616008041 acyl-CoA synthetase; Validated; Region: PRK05850 652616008042 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 652616008043 acyl-activating enzyme (AAE) consensus motif; other site 652616008044 active site 652616008045 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 652616008046 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 652616008047 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 652616008048 active site 652616008049 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 652616008050 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 652616008051 NADP binding site [chemical binding]; other site 652616008052 KR domain; Region: KR; pfam08659 652616008053 active site 652616008054 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 652616008055 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 652616008056 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 652616008057 active site 652616008058 Acyl transferase domain; Region: Acyl_transf_1; cl08282 652616008059 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 652616008060 KR domain; Region: KR; pfam08659 652616008061 NADP binding site [chemical binding]; other site 652616008062 active site 652616008063 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 652616008064 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 652616008065 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 652616008066 active site 652616008067 Acyl transferase domain; Region: Acyl_transf_1; cl08282 652616008068 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 652616008069 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 652616008070 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 652616008071 Enoylreductase; Region: PKS_ER; smart00829 652616008072 NAD(P) binding site [chemical binding]; other site 652616008073 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 652616008074 KR domain; Region: KR; pfam08659 652616008075 putative NADP binding site [chemical binding]; other site 652616008076 active site 652616008077 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 652616008078 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 652616008079 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 652616008080 active site 652616008081 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 652616008082 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 652616008083 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 652616008084 KR domain; Region: KR; pfam08659 652616008085 putative NADP binding site [chemical binding]; other site 652616008086 active site 652616008087 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 652616008088 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 652616008089 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 652616008090 active site 652616008091 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 652616008092 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 652616008093 Condensation domain; Region: Condensation; pfam00668 652616008094 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 652616008095 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 652616008096 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 652616008097 Walker A/P-loop; other site 652616008098 ATP binding site [chemical binding]; other site 652616008099 Q-loop/lid; other site 652616008100 ABC transporter signature motif; other site 652616008101 Walker B; other site 652616008102 D-loop; other site 652616008103 H-loop/switch region; other site 652616008104 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 652616008105 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 652616008106 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 652616008107 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 652616008108 acyltransferase PapA5; Provisional; Region: PRK09294 652616008109 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 652616008110 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 652616008111 active site 652616008112 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 652616008113 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 652616008114 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 652616008115 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 652616008116 Enoylreductase; Region: PKS_ER; smart00829 652616008117 NAD(P) binding site [chemical binding]; other site 652616008118 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 652616008119 KR domain; Region: KR; pfam08659 652616008120 putative NADP binding site [chemical binding]; other site 652616008121 active site 652616008122 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 652616008123 acyl-CoA synthetase; Validated; Region: PRK05850 652616008124 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 652616008125 acyl-activating enzyme (AAE) consensus motif; other site 652616008126 active site 652616008127 MMPL family; Region: MMPL; pfam03176 652616008128 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 652616008129 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 652616008130 Integrase core domain; Region: rve; pfam00665 652616008131 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 652616008132 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 652616008133 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 652616008134 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 652616008135 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 652616008136 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 652616008137 Enoylreductase; Region: PKS_ER; smart00829 652616008138 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 652616008139 NAD(P) binding site [chemical binding]; other site 652616008140 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 652616008141 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 652616008142 putative NADP binding site [chemical binding]; other site 652616008143 active site 652616008144 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 652616008145 Erythronolide synthase docking; Region: Docking; pfam08990 652616008146 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 652616008147 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 652616008148 active site 652616008149 acyl-CoA synthetase; Validated; Region: PRK06060 652616008150 Benzoate CoA ligase (BCL) and similar adenylate forming enzymes; Region: BCL_like; cd05919 652616008151 dimer interface [polypeptide binding]; other site 652616008152 acyl-activating enzyme (AAE) consensus motif; other site 652616008153 putative active site [active] 652616008154 putative AMP binding site [chemical binding]; other site 652616008155 putative CoA binding site [chemical binding]; other site 652616008156 chemical substrate binding site [chemical binding]; other site 652616008157 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 652616008158 acyl-CoA synthetase; Validated; Region: PRK05850 652616008159 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 652616008160 acyl-activating enzyme (AAE) consensus motif; other site 652616008161 active site 652616008162 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 652616008163 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 652616008164 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 652616008165 S-adenosylmethionine binding site [chemical binding]; other site 652616008166 Uncharacterized conserved protein [Function unknown]; Region: COG3268 652616008167 Methyltransferase domain; Region: Methyltransf_23; pfam13489 652616008168 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 652616008169 S-adenosylmethionine binding site [chemical binding]; other site 652616008170 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 652616008171 Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387 652616008172 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 652616008173 metal-binding site 652616008174 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 652616008175 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 652616008176 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 652616008177 active site 652616008178 TDP-binding site; other site 652616008179 acceptor substrate-binding pocket; other site 652616008180 Cephalosporin hydroxylase [Defense mechanisms]; Region: CmcI; COG3510 652616008181 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 652616008182 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 652616008183 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 652616008184 active site 652616008185 TDP-binding site; other site 652616008186 Predicted permease; Region: DUF318; pfam03773 652616008187 formyltetrahydrofolate deformylase; Region: PurU; TIGR00655 652616008188 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 652616008189 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 652616008190 putative active site [active] 652616008191 putative substrate binding site [chemical binding]; other site 652616008192 putative cosubstrate binding site; other site 652616008193 catalytic site [active] 652616008194 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 652616008195 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 652616008196 active site 652616008197 (T/H)XGH motif; other site 652616008198 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 652616008199 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 652616008200 S-adenosylmethionine binding site [chemical binding]; other site 652616008201 pyruvate carboxylase; Reviewed; Region: PRK12999 652616008202 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 652616008203 ATP-grasp domain; Region: ATP-grasp_4; cl17255 652616008204 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 652616008205 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 652616008206 active site 652616008207 catalytic residues [active] 652616008208 metal binding site [ion binding]; metal-binding site 652616008209 homodimer binding site [polypeptide binding]; other site 652616008210 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 652616008211 carboxyltransferase (CT) interaction site; other site 652616008212 biotinylation site [posttranslational modification]; other site 652616008213 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 652616008214 putative active site [active] 652616008215 redox center [active] 652616008216 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 652616008217 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 652616008218 catalytic residues [active] 652616008219 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 652616008220 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 652616008221 substrate binding pocket [chemical binding]; other site 652616008222 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 652616008223 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 652616008224 active site 652616008225 catalytic tetrad [active] 652616008226 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 652616008227 RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200 652616008228 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 652616008229 generic binding surface II; other site 652616008230 ssDNA binding site; other site 652616008231 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 652616008232 ATP binding site [chemical binding]; other site 652616008233 putative Mg++ binding site [ion binding]; other site 652616008234 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 652616008235 nucleotide binding region [chemical binding]; other site 652616008236 ATP-binding site [chemical binding]; other site 652616008237 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 652616008238 DAK2 domain; Region: Dak2; cl03685 652616008239 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 652616008240 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 652616008241 ligand binding site [chemical binding]; other site 652616008242 active site 652616008243 UGI interface [polypeptide binding]; other site 652616008244 catalytic site [active] 652616008245 thiamine monophosphate kinase; Provisional; Region: PRK05731 652616008246 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 652616008247 ATP binding site [chemical binding]; other site 652616008248 dimerization interface [polypeptide binding]; other site 652616008249 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 652616008250 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 652616008251 Probable transposase; Region: OrfB_IS605; pfam01385 652616008252 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 652616008253 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 652616008254 catalytic residues [active] 652616008255 catalytic nucleophile [active] 652616008256 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 652616008257 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 652616008258 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 652616008259 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 652616008260 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 652616008261 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 652616008262 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 652616008263 Predicted nucleotidyltransferase, CobY/MobA/RfbA family [General function prediction only]; Region: COG1920 652616008264 polyphosphate kinase; Provisional; Region: PRK05443 652616008265 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 652616008266 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 652616008267 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 652616008268 putative domain interface [polypeptide binding]; other site 652616008269 putative active site [active] 652616008270 catalytic site [active] 652616008271 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 652616008272 putative domain interface [polypeptide binding]; other site 652616008273 putative active site [active] 652616008274 catalytic site [active] 652616008275 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 652616008276 active site 652616008277 Ap6A binding site [chemical binding]; other site 652616008278 nudix motif; other site 652616008279 metal binding site [ion binding]; metal-binding site 652616008280 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 652616008281 catalytic core [active] 652616008282 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 652616008283 IHF - DNA interface [nucleotide binding]; other site 652616008284 IHF dimer interface [polypeptide binding]; other site 652616008285 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 652616008286 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 652616008287 substrate binding site [chemical binding]; other site 652616008288 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 652616008289 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 652616008290 substrate binding site [chemical binding]; other site 652616008291 ligand binding site [chemical binding]; other site 652616008292 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 652616008293 Transcriptional regulator [Transcription]; Region: IclR; COG1414 652616008294 Bacterial transcriptional regulator; Region: IclR; pfam01614 652616008295 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 652616008296 S-adenosylmethionine binding site [chemical binding]; other site 652616008297 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 652616008298 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 652616008299 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 652616008300 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 652616008301 active site 652616008302 HIGH motif; other site 652616008303 nucleotide binding site [chemical binding]; other site 652616008304 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 652616008305 active site 652616008306 KMSKS motif; other site 652616008307 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 652616008308 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 652616008309 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 652616008310 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 652616008311 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 652616008312 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 652616008313 ligand binding site [chemical binding]; other site 652616008314 NAD binding site [chemical binding]; other site 652616008315 dimerization interface [polypeptide binding]; other site 652616008316 catalytic site [active] 652616008317 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 652616008318 putative L-serine binding site [chemical binding]; other site 652616008319 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 652616008320 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 652616008321 Protein of unknown function (DUF433); Region: DUF433; pfam04255 652616008322 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 652616008323 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 652616008324 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 652616008325 ketol-acid reductoisomerase; Provisional; Region: PRK05479 652616008326 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 652616008327 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 652616008328 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 652616008329 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 652616008330 putative valine binding site [chemical binding]; other site 652616008331 dimer interface [polypeptide binding]; other site 652616008332 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 652616008333 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 652616008334 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 652616008335 PYR/PP interface [polypeptide binding]; other site 652616008336 dimer interface [polypeptide binding]; other site 652616008337 TPP binding site [chemical binding]; other site 652616008338 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 652616008339 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 652616008340 TPP-binding site [chemical binding]; other site 652616008341 dimer interface [polypeptide binding]; other site 652616008342 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 652616008343 Predicted membrane protein [Function unknown]; Region: COG2259 652616008344 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 652616008345 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 652616008346 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 652616008347 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 652616008348 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 652616008349 GatB domain; Region: GatB_Yqey; smart00845 652616008350 6-phosphofructokinase; Provisional; Region: PRK03202 652616008351 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 652616008352 active site 652616008353 ADP/pyrophosphate binding site [chemical binding]; other site 652616008354 dimerization interface [polypeptide binding]; other site 652616008355 allosteric effector site; other site 652616008356 fructose-1,6-bisphosphate binding site; other site 652616008357 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 652616008358 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 652616008359 aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, C subunit; Region: gatC; TIGR00135 652616008360 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 652616008361 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 652616008362 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 652616008363 nucleotide binding pocket [chemical binding]; other site 652616008364 K-X-D-G motif; other site 652616008365 catalytic site [active] 652616008366 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 652616008367 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 652616008368 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 652616008369 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 652616008370 Dimer interface [polypeptide binding]; other site 652616008371 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 652616008372 PknH-like extracellular domain; Region: PknH_C; pfam14032 652616008373 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 652616008374 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616008375 PPE family; Region: PPE; pfam00823 652616008376 Transposase, Mutator family; Region: Transposase_mut; pfam00872 652616008377 MULE transposase domain; Region: MULE; pfam10551 652616008378 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 652616008379 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 652616008380 Ligand Binding Site [chemical binding]; other site 652616008381 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 652616008382 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 652616008383 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 652616008384 catalytic residue [active] 652616008385 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 652616008386 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 652616008387 putative acyl-acceptor binding pocket; other site 652616008388 Putative hemolysin [General function prediction only]; Region: COG3176 652616008389 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 652616008390 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 652616008391 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 652616008392 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 652616008393 Ligand binding site [chemical binding]; other site 652616008394 Electron transfer flavoprotein domain; Region: ETF; pfam01012 652616008395 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 652616008396 S-adenosylmethionine binding site [chemical binding]; other site 652616008397 Uncharacterized conserved protein [Function unknown]; Region: COG1543 652616008398 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 652616008399 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 652616008400 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 652616008401 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 652616008402 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 652616008403 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 652616008404 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 652616008405 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 652616008406 trimer interface [polypeptide binding]; other site 652616008407 active site 652616008408 substrate binding site [chemical binding]; other site 652616008409 CoA binding site [chemical binding]; other site 652616008410 FOG: WD40-like repeat [Function unknown]; Region: COG1520 652616008411 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 652616008412 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 652616008413 S-adenosylmethionine binding site [chemical binding]; other site 652616008414 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 652616008415 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 652616008416 substrate binding site [chemical binding]; other site 652616008417 oxyanion hole (OAH) forming residues; other site 652616008418 trimer interface [polypeptide binding]; other site 652616008419 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 652616008420 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 652616008421 Walker A/P-loop; other site 652616008422 ATP binding site [chemical binding]; other site 652616008423 Q-loop/lid; other site 652616008424 ABC transporter signature motif; other site 652616008425 Walker B; other site 652616008426 D-loop; other site 652616008427 H-loop/switch region; other site 652616008428 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 652616008429 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 652616008430 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 652616008431 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 652616008432 motif II; other site 652616008433 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 652616008434 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 652616008435 D-pathway; other site 652616008436 Putative ubiquinol binding site [chemical binding]; other site 652616008437 Low-spin heme (heme b) binding site [chemical binding]; other site 652616008438 Putative water exit pathway; other site 652616008439 Binuclear center (heme o3/CuB) [ion binding]; other site 652616008440 K-pathway; other site 652616008441 Putative proton exit pathway; other site 652616008442 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 652616008443 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 652616008444 siderophore binding site; other site 652616008445 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 652616008446 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 652616008447 putative NAD(P) binding site [chemical binding]; other site 652616008448 putative substrate binding site [chemical binding]; other site 652616008449 catalytic Zn binding site [ion binding]; other site 652616008450 structural Zn binding site [ion binding]; other site 652616008451 dimer interface [polypeptide binding]; other site 652616008452 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 652616008453 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 652616008454 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 652616008455 dimer interface [polypeptide binding]; other site 652616008456 putative radical transfer pathway; other site 652616008457 diiron center [ion binding]; other site 652616008458 tyrosyl radical; other site 652616008459 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 652616008460 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 652616008461 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 652616008462 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 652616008463 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 652616008464 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 652616008465 Class I ribonucleotide reductase; Region: RNR_I; cd01679 652616008466 active site 652616008467 dimer interface [polypeptide binding]; other site 652616008468 catalytic residues [active] 652616008469 effector binding site; other site 652616008470 R2 peptide binding site; other site 652616008471 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 652616008472 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 652616008473 catalytic residues [active] 652616008474 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 652616008475 Predicted flavoprotein [General function prediction only]; Region: COG0431 652616008476 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 652616008477 DNA polymerase IV; Validated; Region: PRK03352 652616008478 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 652616008479 active site 652616008480 DNA binding site [nucleotide binding] 652616008481 short chain dehydrogenase; Provisional; Region: PRK07832 652616008482 classical (c) SDRs; Region: SDR_c; cd05233 652616008483 NAD(P) binding site [chemical binding]; other site 652616008484 active site 652616008485 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 652616008486 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 652616008487 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 652616008488 Cytochrome P450; Region: p450; cl12078 652616008489 Transcriptional regulators [Transcription]; Region: FadR; COG2186 652616008490 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 652616008491 DNA-binding site [nucleotide binding]; DNA binding site 652616008492 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 652616008493 Transcriptional regulators [Transcription]; Region: FadR; COG2186 652616008494 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 652616008495 DNA-binding site [nucleotide binding]; DNA binding site 652616008496 FCD domain; Region: FCD; pfam07729 652616008497 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 652616008498 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 652616008499 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 652616008500 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 652616008501 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 652616008502 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 652616008503 active site 652616008504 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 652616008505 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 652616008506 active site 652616008507 DNA binding site [nucleotide binding] 652616008508 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 652616008509 DNA binding site [nucleotide binding] 652616008510 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 652616008511 Carbon starvation protein CstA; Region: CstA; pfam02554 652616008512 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 652616008513 Predicted membrane protein [Function unknown]; Region: COG2259 652616008514 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 652616008515 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 652616008516 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 652616008517 Protein of unknown function (DUF732); Region: DUF732; pfam05305 652616008518 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 652616008519 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 652616008520 active site 652616008521 substrate binding site [chemical binding]; other site 652616008522 metal binding site [ion binding]; metal-binding site 652616008523 camphor resistance protein CrcB; Provisional; Region: PRK14216 652616008524 camphor resistance protein CrcB; Provisional; Region: PRK14228 652616008525 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 652616008526 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 652616008527 Uncharacterized ACR, COG1993; Region: DUF190; pfam02641 652616008528 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 652616008529 Uncharacterized conserved protein [Function unknown]; Region: COG3189 652616008530 Domain of unknown function (DUF222); Region: DUF222; pfam02720 652616008531 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 652616008532 active site 652616008533 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 652616008534 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 652616008535 putative hydrophobic ligand binding site [chemical binding]; other site 652616008536 protein interface [polypeptide binding]; other site 652616008537 gate; other site 652616008538 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 652616008539 Sulfatase; Region: Sulfatase; pfam00884 652616008540 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 652616008541 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 652616008542 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 652616008543 Catalytic domain of Protein Kinases; Region: PKc; cd00180 652616008544 active site 652616008545 ATP binding site [chemical binding]; other site 652616008546 substrate binding site [chemical binding]; other site 652616008547 activation loop (A-loop); other site 652616008548 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 652616008549 AAA ATPase domain; Region: AAA_16; pfam13191 652616008550 Nucleotidyl transferase of unknown function (DUF2204); Region: DUF2204; cl17690 652616008551 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 652616008552 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 652616008553 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 652616008554 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 652616008555 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 652616008556 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 652616008557 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 652616008558 short chain dehydrogenase; Provisional; Region: PRK07832 652616008559 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 652616008560 NAD(P) binding site [chemical binding]; other site 652616008561 active site 652616008562 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 652616008563 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 652616008564 NAD binding site [chemical binding]; other site 652616008565 catalytic Zn binding site [ion binding]; other site 652616008566 substrate binding site [chemical binding]; other site 652616008567 structural Zn binding site [ion binding]; other site 652616008568 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 652616008569 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 652616008570 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 652616008571 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 652616008572 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 652616008573 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 652616008574 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 652616008575 acyl-activating enzyme (AAE) consensus motif; other site 652616008576 AMP binding site [chemical binding]; other site 652616008577 active site 652616008578 CoA binding site [chemical binding]; other site 652616008579 SPFH domain / Band 7 family; Region: Band_7; pfam01145 652616008580 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 652616008581 Patatin-like phospholipase; Region: Patatin; pfam01734 652616008582 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 652616008583 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 652616008584 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 652616008585 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 652616008586 active site 652616008587 Predicted transcriptional regulators [Transcription]; Region: COG1733 652616008588 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 652616008589 dimerization interface [polypeptide binding]; other site 652616008590 putative DNA binding site [nucleotide binding]; other site 652616008591 putative Zn2+ binding site [ion binding]; other site 652616008592 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 652616008593 PE family; Region: PE; pfam00934 652616008594 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 652616008595 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 652616008596 De-etiolated protein 1 Det1; Region: Det1; pfam09737 652616008597 PemK-like protein; Region: PemK; cl00995 652616008598 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 652616008599 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 652616008600 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 652616008601 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 652616008602 SmpB-tmRNA interface; other site 652616008603 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 652616008604 FtsX-like permease family; Region: FtsX; pfam02687 652616008605 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 652616008606 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 652616008607 Walker A/P-loop; other site 652616008608 ATP binding site [chemical binding]; other site 652616008609 Q-loop/lid; other site 652616008610 ABC transporter signature motif; other site 652616008611 Walker B; other site 652616008612 D-loop; other site 652616008613 H-loop/switch region; other site 652616008614 Mechanosensitive ion channel; Region: MS_channel; pfam00924 652616008615 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 652616008616 peptide chain release factor 2; Validated; Region: prfB; PRK00578 652616008617 This domain is found in peptide chain release factors; Region: PCRF; smart00937 652616008618 RF-1 domain; Region: RF-1; pfam00472 652616008619 ferredoxin-NADP+ reductase; Region: PLN02852 652616008620 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 652616008621 FAD binding domain; Region: FAD_binding_4; pfam01565 652616008622 Molybdenum cofactor biosynthesis enzyme [Coenzyme metabolism]; Region: MoaA; COG2896 652616008623 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 652616008624 FeS/SAM binding site; other site 652616008625 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 652616008626 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 652616008627 aromatic arch; other site 652616008628 DCoH dimer interaction site [polypeptide binding]; other site 652616008629 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 652616008630 DCoH tetramer interaction site [polypeptide binding]; other site 652616008631 substrate binding site [chemical binding]; other site 652616008632 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 652616008633 trimer interface [polypeptide binding]; other site 652616008634 dimer interface [polypeptide binding]; other site 652616008635 putative active site [active] 652616008636 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 652616008637 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 652616008638 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 652616008639 nucleoside/Zn binding site; other site 652616008640 dimer interface [polypeptide binding]; other site 652616008641 catalytic motif [active] 652616008642 Transposase, Mutator family; Region: Transposase_mut; pfam00872 652616008643 MULE transposase domain; Region: MULE; pfam10551 652616008644 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 652616008645 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 652616008646 ATP binding site [chemical binding]; other site 652616008647 substrate interface [chemical binding]; other site 652616008648 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 652616008649 active site residue [active] 652616008650 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 652616008651 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 652616008652 active site residue [active] 652616008653 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 652616008654 active site residue [active] 652616008655 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 652616008656 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 652616008657 MoaE homodimer interface [polypeptide binding]; other site 652616008658 MoaD interaction [polypeptide binding]; other site 652616008659 active site residues [active] 652616008660 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 652616008661 S-adenosylmethionine binding site [chemical binding]; other site 652616008662 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 652616008663 Cytochrome P450; Region: p450; cl12078 652616008664 Transposase IS200 like; Region: Y1_Tnp; cl00848 652616008665 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 652616008666 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 652616008667 DNA binding site [nucleotide binding] 652616008668 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616008669 PPE family; Region: PPE; pfam00823 652616008670 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 652616008671 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; cl17869 652616008672 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 652616008673 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 652616008674 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 652616008675 dimer interface [polypeptide binding]; other site 652616008676 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 652616008677 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 652616008678 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 652616008679 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 652616008680 Histidine kinase; Region: HisKA_3; pfam07730 652616008681 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 652616008682 ATP binding site [chemical binding]; other site 652616008683 Mg2+ binding site [ion binding]; other site 652616008684 G-X-G motif; other site 652616008685 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 652616008686 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 652616008687 active site 652616008688 phosphorylation site [posttranslational modification] 652616008689 intermolecular recognition site; other site 652616008690 dimerization interface [polypeptide binding]; other site 652616008691 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 652616008692 DNA binding residues [nucleotide binding] 652616008693 dimerization interface [polypeptide binding]; other site 652616008694 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 652616008695 Ligand Binding Site [chemical binding]; other site 652616008696 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616008697 PPE family; Region: PPE; pfam00823 652616008698 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 652616008699 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 652616008700 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 652616008701 active site 652616008702 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 652616008703 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 652616008704 FeS/SAM binding site; other site 652616008705 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 652616008706 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 652616008707 active site 652616008708 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 652616008709 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 652616008710 active site 652616008711 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 652616008712 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 652616008713 NAD(P) binding site [chemical binding]; other site 652616008714 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 652616008715 active site 652616008716 phosphorylation site [posttranslational modification] 652616008717 intermolecular recognition site; other site 652616008718 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616008719 PPE family; Region: PPE; pfam00823 652616008720 NADH dehydrogenase subunit A; Validated; Region: PRK07928 652616008721 NADH dehydrogenase subunit B; Validated; Region: PRK06411 652616008722 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 652616008723 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 652616008724 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 652616008725 NADH dehydrogenase subunit D; Validated; Region: PRK06075 652616008726 NADH dehydrogenase subunit E; Validated; Region: PRK07539 652616008727 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 652616008728 putative dimer interface [polypeptide binding]; other site 652616008729 [2Fe-2S] cluster binding site [ion binding]; other site 652616008730 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 652616008731 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 652616008732 SLBB domain; Region: SLBB; pfam10531 652616008733 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 652616008734 NADH dehydrogenase subunit G; Validated; Region: PRK07860 652616008735 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 652616008736 catalytic loop [active] 652616008737 iron binding site [ion binding]; other site 652616008738 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 652616008739 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 652616008740 [4Fe-4S] binding site [ion binding]; other site 652616008741 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 652616008742 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 652616008743 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 652616008744 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 652616008745 4Fe-4S binding domain; Region: Fer4; pfam00037 652616008746 4Fe-4S binding domain; Region: Fer4; pfam00037 652616008747 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 652616008748 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 652616008749 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 652616008750 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 652616008751 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 652616008752 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 652616008753 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 652616008754 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 652616008755 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 652616008756 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616008757 PPE family; Region: PPE; pfam00823 652616008758 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 652616008759 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 652616008760 [2Fe-2S] cluster binding site [ion binding]; other site 652616008761 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_1; cd08885 652616008762 putative alpha subunit interface [polypeptide binding]; other site 652616008763 putative active site [active] 652616008764 putative substrate binding site [chemical binding]; other site 652616008765 Fe binding site [ion binding]; other site 652616008766 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 652616008767 Protein of unknown function DUF58; Region: DUF58; pfam01882 652616008768 MoxR-like ATPases [General function prediction only]; Region: COG0714 652616008769 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 652616008770 Walker A motif; other site 652616008771 ATP binding site [chemical binding]; other site 652616008772 Walker B motif; other site 652616008773 arginine finger; other site 652616008774 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 652616008775 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 652616008776 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 652616008777 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 652616008778 putative active site [active] 652616008779 putative substrate binding site [chemical binding]; other site 652616008780 ATP binding site [chemical binding]; other site 652616008781 Phosphotransferase enzyme family; Region: APH; pfam01636 652616008782 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 652616008783 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 652616008784 hydroxyglutarate oxidase; Provisional; Region: PRK11728 652616008785 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 652616008786 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 652616008787 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 652616008788 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 652616008789 short chain dehydrogenase; Validated; Region: PRK08264 652616008790 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 652616008791 NAD(P) binding site [chemical binding]; other site 652616008792 active site 652616008793 amidase; Provisional; Region: PRK06170 652616008794 Amidase; Region: Amidase; pfam01425 652616008795 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 652616008796 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 652616008797 TAP-like protein; Region: Abhydrolase_4; pfam08386 652616008798 Domain of unknown function (DUF385); Region: DUF385; pfam04075 652616008799 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 652616008800 AAA domain; Region: AAA_14; pfam13173 652616008801 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 652616008802 putative active site [active] 652616008803 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 652616008804 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4683 652616008805 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 652616008806 non-specific DNA binding site [nucleotide binding]; other site 652616008807 salt bridge; other site 652616008808 sequence-specific DNA binding site [nucleotide binding]; other site 652616008809 Winged helix-turn helix; Region: HTH_29; pfam13551 652616008810 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 652616008811 Helix-turn-helix domain; Region: HTH_38; pfam13936 652616008812 Integrase core domain; Region: rve; pfam00665 652616008813 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 652616008814 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 652616008815 Uncharacterized conserved protein [Function unknown]; Region: COG1615 652616008816 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 652616008817 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 652616008818 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 652616008819 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 652616008820 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 652616008821 Uncharacterized conserved protein [Function unknown]; Region: COG5282 652616008822 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 652616008823 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 652616008824 ABC1 family; Region: ABC1; pfam03109 652616008825 Phosphotransferase enzyme family; Region: APH; pfam01636 652616008826 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 652616008827 active site 652616008828 ATP binding site [chemical binding]; other site 652616008829 Transcription factor WhiB; Region: Whib; pfam02467 652616008830 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 652616008831 Part of AAA domain; Region: AAA_19; pfam13245 652616008832 Family description; Region: UvrD_C_2; pfam13538 652616008833 HRDC domain; Region: HRDC; pfam00570 652616008834 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 652616008835 catalytic residues [active] 652616008836 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 652616008837 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 652616008838 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 652616008839 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 652616008840 putative NADH binding site [chemical binding]; other site 652616008841 putative active site [active] 652616008842 nudix motif; other site 652616008843 putative metal binding site [ion binding]; other site 652616008844 Ion channel; Region: Ion_trans_2; pfam07885 652616008845 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 652616008846 TrkA-N domain; Region: TrkA_N; pfam02254 652616008847 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 652616008848 Part of AAA domain; Region: AAA_19; pfam13245 652616008849 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 652616008850 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 652616008851 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 652616008852 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 652616008853 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 652616008854 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 652616008855 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 652616008856 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 652616008857 active site 652616008858 DNA binding site [nucleotide binding] 652616008859 TIGR02569 family protein; Region: TIGR02569_actnb 652616008860 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 652616008861 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 652616008862 ATP binding site [chemical binding]; other site 652616008863 substrate interface [chemical binding]; other site 652616008864 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 652616008865 active site residue [active] 652616008866 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 652616008867 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 652616008868 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like; Region: MiaE_2; pfam13794 652616008869 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 652616008870 DEAD-like helicases superfamily; Region: DEXDc; smart00487 652616008871 ATP binding site [chemical binding]; other site 652616008872 Mg++ binding site [ion binding]; other site 652616008873 motif III; other site 652616008874 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 652616008875 nucleotide binding region [chemical binding]; other site 652616008876 ATP-binding site [chemical binding]; other site 652616008877 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 652616008878 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 652616008879 P-loop; other site 652616008880 Magnesium ion binding site [ion binding]; other site 652616008881 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 652616008882 Magnesium ion binding site [ion binding]; other site 652616008883 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 652616008884 catalytic core [active] 652616008885 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 652616008886 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 652616008887 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 652616008888 Transcription factor WhiB; Region: Whib; pfam02467 652616008889 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 652616008890 PAS domain S-box; Region: sensory_box; TIGR00229 652616008891 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 652616008892 Histidine kinase; Region: HisKA_2; pfam07568 652616008893 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 652616008894 ATP binding site [chemical binding]; other site 652616008895 Mg2+ binding site [ion binding]; other site 652616008896 G-X-G motif; other site 652616008897 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 652616008898 carboxyltransferase (CT) interaction site; other site 652616008899 biotinylation site [posttranslational modification]; other site 652616008900 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 652616008901 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 652616008902 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 652616008903 DNA binding residues [nucleotide binding] 652616008904 short chain dehydrogenase; Provisional; Region: PRK08278 652616008905 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 652616008906 NAD(P) binding site [chemical binding]; other site 652616008907 homodimer interface [polypeptide binding]; other site 652616008908 active site 652616008909 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 652616008910 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 652616008911 Coenzyme A binding pocket [chemical binding]; other site 652616008912 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 652616008913 Phosphotransferase enzyme family; Region: APH; pfam01636 652616008914 putative active site [active] 652616008915 putative substrate binding site [chemical binding]; other site 652616008916 ATP binding site [chemical binding]; other site 652616008917 Uncharacterized conserved protein [Function unknown]; Region: COG2135 652616008918 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 652616008919 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 652616008920 hinge; other site 652616008921 active site 652616008922 Predicted GTPases [General function prediction only]; Region: COG1162 652616008923 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 652616008924 GTPase/Zn-binding domain interface [polypeptide binding]; other site 652616008925 GTP/Mg2+ binding site [chemical binding]; other site 652616008926 G4 box; other site 652616008927 G5 box; other site 652616008928 G1 box; other site 652616008929 Switch I region; other site 652616008930 G2 box; other site 652616008931 G3 box; other site 652616008932 Switch II region; other site 652616008933 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 652616008934 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 652616008935 putative di-iron ligands [ion binding]; other site 652616008936 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 652616008937 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 652616008938 FAD binding pocket [chemical binding]; other site 652616008939 FAD binding motif [chemical binding]; other site 652616008940 phosphate binding motif [ion binding]; other site 652616008941 beta-alpha-beta structure motif; other site 652616008942 NAD binding pocket [chemical binding]; other site 652616008943 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 652616008944 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 652616008945 catalytic loop [active] 652616008946 iron binding site [ion binding]; other site 652616008947 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 652616008948 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 652616008949 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 652616008950 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 652616008951 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 652616008952 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 652616008953 TrkA-C domain; Region: TrkA_C; pfam02080 652616008954 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 652616008955 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 652616008956 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 652616008957 putative substrate translocation pore; other site 652616008958 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 652616008959 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 652616008960 ligand binding site [chemical binding]; other site 652616008961 flexible hinge region; other site 652616008962 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 652616008963 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 652616008964 nucleophile elbow; other site 652616008965 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 652616008966 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 652616008967 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 652616008968 30S subunit binding site; other site 652616008969 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 652616008970 active site 652616008971 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 652616008972 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 652616008973 lipoprotein LpqB; Provisional; Region: PRK13616 652616008974 Sporulation and spore germination; Region: Germane; pfam10646 652616008975 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 652616008976 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 652616008977 dimerization interface [polypeptide binding]; other site 652616008978 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 652616008979 dimer interface [polypeptide binding]; other site 652616008980 phosphorylation site [posttranslational modification] 652616008981 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 652616008982 ATP binding site [chemical binding]; other site 652616008983 Mg2+ binding site [ion binding]; other site 652616008984 G-X-G motif; other site 652616008985 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 652616008986 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 652616008987 active site 652616008988 phosphorylation site [posttranslational modification] 652616008989 intermolecular recognition site; other site 652616008990 dimerization interface [polypeptide binding]; other site 652616008991 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 652616008992 DNA binding site [nucleotide binding] 652616008993 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 652616008994 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 652616008995 TMP-binding site; other site 652616008996 ATP-binding site [chemical binding]; other site 652616008997 Adenosylhomocysteinase; Provisional; Region: PTZ00075 652616008998 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 652616008999 homotetramer interface [polypeptide binding]; other site 652616009000 ligand binding site [chemical binding]; other site 652616009001 catalytic site [active] 652616009002 NAD binding site [chemical binding]; other site 652616009003 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 652616009004 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 652616009005 Rubredoxin [Energy production and conversion]; Region: COG1773 652616009006 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 652616009007 iron binding site [ion binding]; other site 652616009008 Rubredoxin [Energy production and conversion]; Region: COG1773 652616009009 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 652616009010 iron binding site [ion binding]; other site 652616009011 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 652616009012 Fatty acid desaturase; Region: FA_desaturase; pfam00487 652616009013 Di-iron ligands [ion binding]; other site 652616009014 amino acid transporter; Region: 2A0306; TIGR00909 652616009015 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 652616009016 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 652616009017 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 652616009018 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 652616009019 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 652616009020 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 652616009021 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 652616009022 active site 652616009023 substrate binding site [chemical binding]; other site 652616009024 metal binding site [ion binding]; metal-binding site 652616009025 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 652616009026 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 652616009027 Transcription factor WhiB; Region: Whib; pfam02467 652616009028 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 652616009029 LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186 652616009030 phosphate binding site [ion binding]; other site 652616009031 dimer interface [polypeptide binding]; other site 652616009032 substrate binding site [chemical binding]; other site 652616009033 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 652616009034 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 652616009035 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 652616009036 putative FMN binding site [chemical binding]; other site 652616009037 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 652616009038 Methyltransferase domain; Region: Methyltransf_26; pfam13659 652616009039 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 652616009040 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 652616009041 active site 652616009042 Substrate binding site; other site 652616009043 Mg++ binding site; other site 652616009044 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 652616009045 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 652616009046 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 652616009047 Probable Catalytic site; other site 652616009048 metal-binding site 652616009049 dTDP-4-dehydrorhamnose reductase; Region: rmlD; TIGR01214 652616009050 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 652616009051 NADP binding site [chemical binding]; other site 652616009052 active site 652616009053 putative substrate binding site [chemical binding]; other site 652616009054 Transcriptional regulator [Transcription]; Region: LytR; COG1316 652616009055 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 652616009056 TIGR03089 family protein; Region: TIGR03089 652616009057 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 652616009058 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 652616009059 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 652616009060 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 652616009061 active site 652616009062 motif I; other site 652616009063 motif II; other site 652616009064 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 652616009065 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 652616009066 CoA-transferase family III; Region: CoA_transf_3; pfam02515 652616009067 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 652616009068 Sulfate transporter family; Region: Sulfate_transp; pfam00916 652616009069 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: CynT; COG0288 652616009070 active site clefts [active] 652616009071 zinc binding site [ion binding]; other site 652616009072 dimer interface [polypeptide binding]; other site 652616009073 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 652616009074 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 652616009075 FAD binding site [chemical binding]; other site 652616009076 homotetramer interface [polypeptide binding]; other site 652616009077 substrate binding pocket [chemical binding]; other site 652616009078 catalytic base [active] 652616009079 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 652616009080 Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) [Nucleotide transport and metabolism]; Region: PurK; COG0026 652616009081 ATP-grasp domain; Region: ATP-grasp; pfam02222 652616009082 Predicted membrane protein [Function unknown]; Region: COG2246 652616009083 GtrA-like protein; Region: GtrA; pfam04138 652616009084 Bacterial PH domain; Region: DUF304; pfam03703 652616009085 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 652616009086 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 652616009087 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 652616009088 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 652616009089 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 652616009090 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 652616009091 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 652616009092 Maf-like protein; Region: Maf; pfam02545 652616009093 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 652616009094 active site 652616009095 dimer interface [polypeptide binding]; other site 652616009096 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 652616009097 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 652616009098 active site residue [active] 652616009099 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 652616009100 active site residue [active] 652616009101 Fe-S metabolism associated domain; Region: SufE; pfam02657 652616009102 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 652616009103 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 652616009104 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 652616009105 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 652616009106 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 652616009107 carboxyltransferase (CT) interaction site; other site 652616009108 biotinylation site [posttranslational modification]; other site 652616009109 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 652616009110 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 652616009111 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 652616009112 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 652616009113 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 652616009114 L-lysine aminotransferase; Provisional; Region: PRK08297 652616009115 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 652616009116 inhibitor-cofactor binding pocket; inhibition site 652616009117 pyridoxal 5'-phosphate binding site [chemical binding]; other site 652616009118 catalytic residue [active] 652616009119 putative DNA binding site [nucleotide binding]; other site 652616009120 dimerization interface [polypeptide binding]; other site 652616009121 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 652616009122 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 652616009123 putative Zn2+ binding site [ion binding]; other site 652616009124 AsnC family; Region: AsnC_trans_reg; pfam01037 652616009125 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 652616009126 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 652616009127 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 652616009128 tetrameric interface [polypeptide binding]; other site 652616009129 NAD binding site [chemical binding]; other site 652616009130 catalytic residues [active] 652616009131 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 652616009132 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 652616009133 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 652616009134 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 652616009135 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 652616009136 ATP binding site [chemical binding]; other site 652616009137 putative Mg++ binding site [ion binding]; other site 652616009138 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 652616009139 nucleotide binding region [chemical binding]; other site 652616009140 ATP-binding site [chemical binding]; other site 652616009141 DEAD/H associated; Region: DEAD_assoc; pfam08494 652616009142 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 652616009143 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 652616009144 putative DNA binding site [nucleotide binding]; other site 652616009145 catalytic residue [active] 652616009146 putative H2TH interface [polypeptide binding]; other site 652616009147 putative catalytic residues [active] 652616009148 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 652616009149 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 652616009150 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 652616009151 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 652616009152 Sulfatase; Region: Sulfatase; pfam00884 652616009153 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 652616009154 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 652616009155 probable active site [active] 652616009156 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 652616009157 PhoU domain; Region: PhoU; pfam01895 652616009158 PhoU domain; Region: PhoU; pfam01895 652616009159 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 652616009160 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 652616009161 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 652616009162 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 652616009163 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 652616009164 putative active site pocket [active] 652616009165 dimerization interface [polypeptide binding]; other site 652616009166 putative catalytic residue [active] 652616009167 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 652616009168 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 652616009169 metal binding site [ion binding]; metal-binding site 652616009170 putative dimer interface [polypeptide binding]; other site 652616009171 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 652616009172 amidohydrolase; Region: amidohydrolases; TIGR01891 652616009173 metal binding site [ion binding]; metal-binding site 652616009174 purine nucleoside phosphorylase; Provisional; Region: PRK08202 652616009175 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 652616009176 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 652616009177 active site 652616009178 substrate binding site [chemical binding]; other site 652616009179 metal binding site [ion binding]; metal-binding site 652616009180 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 652616009181 active site 652616009182 Phosphoesterase family; Region: Phosphoesterase; pfam04185 652616009183 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 652616009184 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 652616009185 adenosine deaminase; Provisional; Region: PRK09358 652616009186 active site 652616009187 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 652616009188 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 652616009189 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 652616009190 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 652616009191 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 652616009192 active site 652616009193 catalytic motif [active] 652616009194 Zn binding site [ion binding]; other site 652616009195 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 652616009196 putative Iron-sulfur protein interface [polypeptide binding]; other site 652616009197 putative proximal heme binding site [chemical binding]; other site 652616009198 putative SdhD-like interface [polypeptide binding]; other site 652616009199 putative distal heme binding site [chemical binding]; other site 652616009200 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 652616009201 putative Iron-sulfur protein interface [polypeptide binding]; other site 652616009202 putative proximal heme binding site [chemical binding]; other site 652616009203 putative SdhC-like subunit interface [polypeptide binding]; other site 652616009204 putative distal heme binding site [chemical binding]; other site 652616009205 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 652616009206 L-aspartate oxidase; Provisional; Region: PRK06175 652616009207 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 652616009208 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 652616009209 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 652616009210 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 652616009211 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 652616009212 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 652616009213 S-adenosylmethionine binding site [chemical binding]; other site 652616009214 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 652616009215 MoaD interaction [polypeptide binding]; other site 652616009216 active site residues [active] 652616009217 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 652616009218 Transposase; Region: HTH_Tnp_1; cl17663 652616009219 putative transposase OrfB; Reviewed; Region: PHA02517 652616009220 HTH-like domain; Region: HTH_21; pfam13276 652616009221 Integrase core domain; Region: rve; pfam00665 652616009222 Integrase core domain; Region: rve_3; pfam13683 652616009223 Transposase; Region: DEDD_Tnp_IS110; pfam01548 652616009224 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 652616009225 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 652616009226 Uncharacterized conserved protein [Function unknown]; Region: COG2128 652616009227 hypothetical protein; Provisional; Region: PRK06541 652616009228 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 652616009229 inhibitor-cofactor binding pocket; inhibition site 652616009230 pyridoxal 5'-phosphate binding site [chemical binding]; other site 652616009231 catalytic residue [active] 652616009232 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 652616009233 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 652616009234 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 652616009235 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 652616009236 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 652616009237 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 652616009238 active site 652616009239 dimer interface [polypeptide binding]; other site 652616009240 Protein of unknown function (DUF732); Region: DUF732; pfam05305 652616009241 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 652616009242 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 652616009243 DNA binding residues [nucleotide binding] 652616009244 dimer interface [polypeptide binding]; other site 652616009245 metal binding site [ion binding]; metal-binding site 652616009246 inner membrane protein YhjD; Region: TIGR00766 652616009247 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 652616009248 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 652616009249 active site 652616009250 HIGH motif; other site 652616009251 dimer interface [polypeptide binding]; other site 652616009252 KMSKS motif; other site 652616009253 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 652616009254 isocitrate dehydrogenase; Validated; Region: PRK08299 652616009255 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 652616009256 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 652616009257 homodimer interface [polypeptide binding]; other site 652616009258 substrate-cofactor binding pocket; other site 652616009259 pyridoxal 5'-phosphate binding site [chemical binding]; other site 652616009260 catalytic residue [active] 652616009261 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 652616009262 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 652616009263 Methyltransferase domain; Region: Methyltransf_23; pfam13489 652616009264 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 652616009265 S-adenosylmethionine binding site [chemical binding]; other site 652616009266 PPE family; Region: PPE; pfam00823 652616009267 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616009268 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616009269 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 652616009270 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 652616009271 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 652616009272 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616009273 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 652616009274 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 652616009275 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616009276 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 652616009277 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 652616009278 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 652616009279 PE family; Region: PE; pfam00934 652616009280 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 652616009281 PPE family; Region: PPE; pfam00823 652616009282 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 652616009283 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 652616009284 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616009285 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 652616009286 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 652616009287 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616009288 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 652616009289 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616009290 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 652616009291 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 652616009292 Transposase; Region: DEDD_Tnp_IS110; pfam01548 652616009293 Transposase; Region: DDE_Tnp_ISL3; pfam01610 652616009294 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 652616009295 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 652616009296 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616009297 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 652616009298 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 652616009299 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 652616009300 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 652616009301 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616009302 PPE family; Region: PPE; pfam00823 652616009303 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616009304 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 652616009305 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 652616009306 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616009307 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 652616009308 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 652616009309 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 652616009310 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 652616009311 Berberine and berberine like; Region: BBE; pfam08031 652616009312 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 652616009313 Protein of unknown function (DUF732); Region: DUF732; pfam05305 652616009314 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 652616009315 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 652616009316 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 652616009317 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 652616009318 homodimer interface [polypeptide binding]; other site 652616009319 NADP binding site [chemical binding]; other site 652616009320 substrate binding site [chemical binding]; other site 652616009321 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 652616009322 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 652616009323 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 652616009324 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 652616009325 active site 652616009326 FMN binding site [chemical binding]; other site 652616009327 substrate binding site [chemical binding]; other site 652616009328 putative catalytic residue [active] 652616009329 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 652616009330 phosphate binding site [ion binding]; other site 652616009331 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 652616009332 phosphopeptide binding site; other site 652616009333 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 652616009334 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 652616009335 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 652616009336 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 652616009337 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 652616009338 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 652616009339 G1 box; other site 652616009340 GTP/Mg2+ binding site [chemical binding]; other site 652616009341 G2 box; other site 652616009342 Switch I region; other site 652616009343 G3 box; other site 652616009344 Switch II region; other site 652616009345 G4 box; other site 652616009346 G5 box; other site 652616009347 Protein of unknown function (DUF742); Region: DUF742; pfam05331 652616009348 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 652616009349 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 652616009350 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 652616009351 ATP binding site [chemical binding]; other site 652616009352 Mg2+ binding site [ion binding]; other site 652616009353 G-X-G motif; other site 652616009354 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 652616009355 PE family; Region: PE; pfam00934 652616009356 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 652616009357 FMN binding site [chemical binding]; other site 652616009358 dimer interface [polypeptide binding]; other site 652616009359 PPOX class probable F420-dependent enzyme, Rv3369 family; Region: Rv3369; TIGR03667 652616009360 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 652616009361 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 652616009362 active site 652616009363 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 652616009364 generic binding surface II; other site 652616009365 generic binding surface I; other site 652616009366 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 652616009367 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 652616009368 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 652616009369 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 652616009370 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 652616009371 active site 652616009372 motif I; other site 652616009373 motif II; other site 652616009374 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 652616009375 substrate binding site [chemical binding]; other site 652616009376 oxyanion hole (OAH) forming residues; other site 652616009377 trimer interface [polypeptide binding]; other site 652616009378 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 652616009379 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 652616009380 Amidase; Region: Amidase; pfam01425 652616009381 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 652616009382 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 652616009383 motif II; other site 652616009384 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 652616009385 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 652616009386 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 652616009387 TPP-binding site [chemical binding]; other site 652616009388 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 652616009389 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 652616009390 PYR/PP interface [polypeptide binding]; other site 652616009391 dimer interface [polypeptide binding]; other site 652616009392 TPP binding site [chemical binding]; other site 652616009393 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 652616009394 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 652616009395 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 652616009396 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 652616009397 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 652616009398 substrate binding pocket [chemical binding]; other site 652616009399 chain length determination region; other site 652616009400 substrate-Mg2+ binding site; other site 652616009401 catalytic residues [active] 652616009402 aspartate-rich region 1; other site 652616009403 active site lid residues [active] 652616009404 aspartate-rich region 2; other site 652616009405 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 652616009406 putative active site [active] 652616009407 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 652616009408 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 652616009409 Transposase domain (DUF772); Region: DUF772; pfam05598 652616009410 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 652616009411 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 652616009412 PE family; Region: PE; pfam00934 652616009413 enoyl-CoA hydratase; Region: PLN02864 652616009414 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 652616009415 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 652616009416 dimer interaction site [polypeptide binding]; other site 652616009417 substrate-binding tunnel; other site 652616009418 active site 652616009419 catalytic site [active] 652616009420 substrate binding site [chemical binding]; other site 652616009421 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 652616009422 short chain dehydrogenase; Provisional; Region: PRK07201 652616009423 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 652616009424 putative NAD(P) binding site [chemical binding]; other site 652616009425 active site 652616009426 putative substrate binding site [chemical binding]; other site 652616009427 classical (c) SDRs; Region: SDR_c; cd05233 652616009428 NAD(P) binding site [chemical binding]; other site 652616009429 active site 652616009430 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 652616009431 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 652616009432 S-adenosylmethionine binding site [chemical binding]; other site 652616009433 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 652616009434 active site 652616009435 DNA Polymerase Y-family; Region: PolY_like; cd03468 652616009436 DNA binding site [nucleotide binding] 652616009437 GMP synthase; Reviewed; Region: guaA; PRK00074 652616009438 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 652616009439 AMP/PPi binding site [chemical binding]; other site 652616009440 candidate oxyanion hole; other site 652616009441 catalytic triad [active] 652616009442 potential glutamine specificity residues [chemical binding]; other site 652616009443 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 652616009444 ATP Binding subdomain [chemical binding]; other site 652616009445 Ligand Binding sites [chemical binding]; other site 652616009446 Dimerization subdomain; other site 652616009447 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 652616009448 active site lid residues [active] 652616009449 substrate binding pocket [chemical binding]; other site 652616009450 catalytic residues [active] 652616009451 substrate-Mg2+ binding site; other site 652616009452 aspartate-rich region 1; other site 652616009453 aspartate-rich region 2; other site 652616009454 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 652616009455 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 652616009456 substrate binding pocket [chemical binding]; other site 652616009457 chain length determination region; other site 652616009458 substrate-Mg2+ binding site; other site 652616009459 catalytic residues [active] 652616009460 aspartate-rich region 1; other site 652616009461 active site lid residues [active] 652616009462 aspartate-rich region 2; other site 652616009463 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 652616009464 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 652616009465 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 652616009466 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 652616009467 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 652616009468 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 652616009469 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 652616009470 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 652616009471 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 652616009472 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 652616009473 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 652616009474 catalytic residue [active] 652616009475 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 652616009476 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 652616009477 hypothetical protein; Provisional; Region: PRK07579 652616009478 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 652616009479 active site 652616009480 cosubstrate binding site; other site 652616009481 substrate binding site [chemical binding]; other site 652616009482 catalytic site [active] 652616009483 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 652616009484 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 652616009485 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 652616009486 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 652616009487 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 652616009488 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 652616009489 putative active site [active] 652616009490 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 652616009491 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 652616009492 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 652616009493 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 652616009494 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 652616009495 phosphate binding site [ion binding]; other site 652616009496 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 652616009497 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 652616009498 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 652616009499 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 652616009500 active site 652616009501 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 652616009502 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 652616009503 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 652616009504 DNA binding residues [nucleotide binding] 652616009505 Transcription factor WhiB; Region: Whib; pfam02467 652616009506 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 652616009507 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 652616009508 ring oligomerisation interface [polypeptide binding]; other site 652616009509 ATP/Mg binding site [chemical binding]; other site 652616009510 stacking interactions; other site 652616009511 hinge regions; other site 652616009512 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 652616009513 oligomerisation interface [polypeptide binding]; other site 652616009514 mobile loop; other site 652616009515 roof hairpin; other site 652616009516 UGMP family protein; Validated; Region: PRK09604 652616009517 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 652616009518 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 652616009519 Coenzyme A binding pocket [chemical binding]; other site 652616009520 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 652616009521 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 652616009522 alanine racemase; Reviewed; Region: alr; PRK00053 652616009523 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 652616009524 active site 652616009525 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 652616009526 dimer interface [polypeptide binding]; other site 652616009527 substrate binding site [chemical binding]; other site 652616009528 catalytic residues [active] 652616009529 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616009530 PPE family; Region: PPE; pfam00823 652616009531 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616009532 PPE family; Region: PPE; pfam00823 652616009533 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 652616009534 Integrase core domain; Region: rve; pfam00665 652616009535 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 652616009536 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 652616009537 Walker A motif; other site 652616009538 ATP binding site [chemical binding]; other site 652616009539 Walker B motif; other site 652616009540 arginine finger; other site 652616009541 PE family; Region: PE; pfam00934 652616009542 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616009543 PPE family; Region: PPE; pfam00823 652616009544 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 652616009545 Integrase core domain; Region: rve; pfam00665 652616009546 Integrase core domain; Region: rve_3; pfam13683 652616009547 Transposase, Mutator family; Region: Transposase_mut; pfam00872 652616009548 MULE transposase domain; Region: MULE; pfam10551 652616009549 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 652616009550 pyridoxal 5'-phosphate binding site [chemical binding]; other site 652616009551 catalytic residue [active] 652616009552 Uncharacterized conserved protein [Function unknown]; Region: COG0062 652616009553 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 652616009554 putative substrate binding site [chemical binding]; other site 652616009555 putative ATP binding site [chemical binding]; other site 652616009556 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 652616009557 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 652616009558 glutaminase active site [active] 652616009559 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 652616009560 dimer interface [polypeptide binding]; other site 652616009561 active site 652616009562 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 652616009563 dimer interface [polypeptide binding]; other site 652616009564 active site 652616009565 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 652616009566 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 652616009567 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 652616009568 active site 652616009569 substrate binding site [chemical binding]; other site 652616009570 metal binding site [ion binding]; metal-binding site 652616009571 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 652616009572 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 652616009573 23S rRNA interface [nucleotide binding]; other site 652616009574 L3 interface [polypeptide binding]; other site 652616009575 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 652616009576 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 652616009577 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 652616009578 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 652616009579 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 652616009580 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 652616009581 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 652616009582 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 652616009583 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 652616009584 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 652616009585 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 652616009586 active site 652616009587 catalytic residues [active] 652616009588 Protein of unknown function (DUF690); Region: DUF690; pfam05108 652616009589 Cutinase; Region: Cutinase; pfam01083 652616009590 Cutinase; Region: Cutinase; pfam01083 652616009591 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 652616009592 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 652616009593 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 652616009594 active site 652616009595 dimerization interface 3.5A [polypeptide binding]; other site 652616009596 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 652616009597 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 652616009598 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 652616009599 alphaNTD - beta interaction site [polypeptide binding]; other site 652616009600 alphaNTD homodimer interface [polypeptide binding]; other site 652616009601 alphaNTD - beta' interaction site [polypeptide binding]; other site 652616009602 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 652616009603 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 652616009604 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 652616009605 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 652616009606 RNA binding surface [nucleotide binding]; other site 652616009607 30S ribosomal protein S11; Validated; Region: PRK05309 652616009608 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 652616009609 30S ribosomal protein S13; Region: bact_S13; TIGR03631 652616009610 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 652616009611 rRNA binding site [nucleotide binding]; other site 652616009612 predicted 30S ribosome binding site; other site 652616009613 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 652616009614 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 652616009615 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 652616009616 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 652616009617 NAD binding site [chemical binding]; other site 652616009618 substrate binding site [chemical binding]; other site 652616009619 homodimer interface [polypeptide binding]; other site 652616009620 active site 652616009621 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 652616009622 Domain of unknown function (DUF222); Region: DUF222; pfam02720 652616009623 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 652616009624 active site 652616009625 Recombinase; Region: Recombinase; pfam07508 652616009626 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 652616009627 Protein of unknown function (DUF2742); Region: DUF2742; pfam10888 652616009628 Phage associated DNA primase [General function prediction only]; Region: COG3378 652616009629 D5 N terminal like; Region: D5_N; smart00885 652616009630 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: COG3747 652616009631 Phage head maturation protease [General function prediction only]; Region: COG3740 652616009632 Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653 652616009633 Phage capsid family; Region: Phage_capsid; pfam05065 652616009634 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 652616009635 extended (e) SDRs; Region: SDR_e; cd08946 652616009636 NAD(P) binding site [chemical binding]; other site 652616009637 active site 652616009638 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 652616009639 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 652616009640 active site 652616009641 catalytic residues [active] 652616009642 metal binding site [ion binding]; metal-binding site 652616009643 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 652616009644 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 652616009645 PYR/PP interface [polypeptide binding]; other site 652616009646 dimer interface [polypeptide binding]; other site 652616009647 TPP binding site [chemical binding]; other site 652616009648 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 652616009649 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 652616009650 TPP-binding site [chemical binding]; other site 652616009651 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 652616009652 SnoaL-like domain; Region: SnoaL_4; pfam13577 652616009653 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 652616009654 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 652616009655 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 652616009656 metabolite-proton symporter; Region: 2A0106; TIGR00883 652616009657 putative substrate translocation pore; other site 652616009658 PE family; Region: PE; pfam00934 652616009659 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616009660 PPE family; Region: PPE; pfam00823 652616009661 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 652616009662 patatin-related protein; Region: TIGR03607 652616009663 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 652616009664 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 652616009665 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 652616009666 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 652616009667 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 652616009668 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 652616009669 Transcriptional regulator [Transcription]; Region: LytR; COG1316 652616009670 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 652616009671 short chain dehydrogenase; Provisional; Region: PRK05875 652616009672 classical (c) SDRs; Region: SDR_c; cd05233 652616009673 NAD(P) binding site [chemical binding]; other site 652616009674 active site 652616009675 Predicted membrane protein [Function unknown]; Region: COG2259 652616009676 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 652616009677 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 652616009678 Predicted transcriptional regulators [Transcription]; Region: COG1695 652616009679 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 652616009680 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 652616009681 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 652616009682 active site 652616009683 homotetramer interface [polypeptide binding]; other site 652616009684 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 652616009685 mce related protein; Region: MCE; pfam02470 652616009686 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 652616009687 mce related protein; Region: MCE; pfam02470 652616009688 mce related protein; Region: MCE; pfam02470 652616009689 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 652616009690 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 652616009691 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 652616009692 mce related protein; Region: MCE; pfam02470 652616009693 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 652616009694 mce related protein; Region: MCE; pfam02470 652616009695 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 652616009696 mce related protein; Region: MCE; pfam02470 652616009697 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 652616009698 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 652616009699 Permease; Region: Permease; pfam02405 652616009700 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 652616009701 Permease; Region: Permease; pfam02405 652616009702 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 652616009703 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 652616009704 NAD(P) binding site [chemical binding]; other site 652616009705 active site 652616009706 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 652616009707 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 652616009708 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 652616009709 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 652616009710 FAD binding site [chemical binding]; other site 652616009711 substrate binding site [chemical binding]; other site 652616009712 catalytic base [active] 652616009713 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 652616009714 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 652616009715 active site 652616009716 acyl-CoA synthetase; Validated; Region: PRK07867 652616009717 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 652616009718 acyl-activating enzyme (AAE) consensus motif; other site 652616009719 putative AMP binding site [chemical binding]; other site 652616009720 putative active site [active] 652616009721 putative CoA binding site [chemical binding]; other site 652616009722 PE family; Region: PE; pfam00934 652616009723 PE family; Region: PE; pfam00934 652616009724 hypothetical protein; Validated; Region: PRK07586 652616009725 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 652616009726 PYR/PP interface [polypeptide binding]; other site 652616009727 dimer interface [polypeptide binding]; other site 652616009728 TPP binding site [chemical binding]; other site 652616009729 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 652616009730 TPP-binding site [chemical binding]; other site 652616009731 dimer interface [polypeptide binding]; other site 652616009732 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 652616009733 PE family; Region: PE; pfam00934 652616009734 acyl-CoA synthetase; Validated; Region: PRK07798 652616009735 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 652616009736 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 652616009737 acyl-activating enzyme (AAE) consensus motif; other site 652616009738 acyl-activating enzyme (AAE) consensus motif; other site 652616009739 putative AMP binding site [chemical binding]; other site 652616009740 putative active site [active] 652616009741 putative CoA binding site [chemical binding]; other site 652616009742 enoyl-CoA hydratase; Provisional; Region: PRK07799 652616009743 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 652616009744 substrate binding site [chemical binding]; other site 652616009745 oxyanion hole (OAH) forming residues; other site 652616009746 trimer interface [polypeptide binding]; other site 652616009747 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 652616009748 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 652616009749 Cytochrome P450; Region: p450; cl12078 652616009750 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 652616009751 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 652616009752 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 652616009753 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 652616009754 DUF35 OB-fold domain; Region: DUF35; pfam01796 652616009755 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 652616009756 DUF35 OB-fold domain; Region: DUF35; pfam01796 652616009757 lipid-transfer protein; Provisional; Region: PRK07937 652616009758 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 652616009759 active site 652616009760 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 652616009761 active site 652616009762 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 652616009763 NHL repeat; Region: NHL; pfam01436 652616009764 Uncharacterized conserved protein [Function unknown]; Region: COG3391 652616009765 NHL repeat; Region: NHL; pfam01436 652616009766 NHL repeat; Region: NHL; pfam01436 652616009767 NHL repeat; Region: NHL; pfam01436 652616009768 NHL repeat; Region: NHL; pfam01436 652616009769 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 652616009770 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 652616009771 trimer interface [polypeptide binding]; other site 652616009772 putative metal binding site [ion binding]; other site 652616009773 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 652616009774 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 652616009775 short chain dehydrogenase; Provisional; Region: PRK07890 652616009776 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 652616009777 NAD(P) binding site [chemical binding]; other site 652616009778 active site 652616009779 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616009780 PPE family; Region: PPE; pfam00823 652616009781 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 652616009782 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616009783 PPE family; Region: PPE; pfam00823 652616009784 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 652616009785 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 652616009786 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 652616009787 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 652616009788 active site 652616009789 catalytic residues [active] 652616009790 metal binding site [ion binding]; metal-binding site 652616009791 DmpG-like communication domain; Region: DmpG_comm; pfam07836 652616009792 acetaldehyde dehydrogenase; Validated; Region: PRK08300 652616009793 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 652616009794 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 652616009795 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971 652616009796 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 652616009797 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 652616009798 enoyl-CoA hydratase; Region: PLN02864 652616009799 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 652616009800 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 652616009801 dimer interaction site [polypeptide binding]; other site 652616009802 substrate-binding tunnel; other site 652616009803 active site 652616009804 catalytic site [active] 652616009805 substrate binding site [chemical binding]; other site 652616009806 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616009807 PPE family; Region: PPE; pfam00823 652616009808 PE-PPE domain; Region: PE-PPE; pfam08237 652616009809 lipid-transfer protein; Provisional; Region: PRK07855 652616009810 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 652616009811 active site 652616009812 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 652616009813 putative active site [active] 652616009814 putative catalytic site [active] 652616009815 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 652616009816 active site 652616009817 catalytic site [active] 652616009818 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 652616009819 DUF35 OB-fold domain; Region: DUF35; pfam01796 652616009820 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 652616009821 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 652616009822 active site 652616009823 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 652616009824 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 652616009825 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 652616009826 active site 652616009827 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 652616009828 Cytochrome P450; Region: p450; cl12078 652616009829 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 652616009830 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 652616009831 dimer interface [polypeptide binding]; other site 652616009832 active site 652616009833 Domain of unknown function (DUF385); Region: DUF385; pfam04075 652616009834 short chain dehydrogenase; Provisional; Region: PRK07791 652616009835 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 652616009836 homodimer interface [polypeptide binding]; other site 652616009837 NAD binding site [chemical binding]; other site 652616009838 active site 652616009839 short chain dehydrogenase; Provisional; Region: PRK07856 652616009840 classical (c) SDRs; Region: SDR_c; cd05233 652616009841 NAD(P) binding site [chemical binding]; other site 652616009842 active site 652616009843 enoyl-CoA hydratase; Provisional; Region: PRK06495 652616009844 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 652616009845 substrate binding site [chemical binding]; other site 652616009846 oxyanion hole (OAH) forming residues; other site 652616009847 trimer interface [polypeptide binding]; other site 652616009848 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 652616009849 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057 652616009850 Nitronate monooxygenase; Region: NMO; pfam03060 652616009851 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 652616009852 FMN binding site [chemical binding]; other site 652616009853 substrate binding site [chemical binding]; other site 652616009854 putative catalytic residue [active] 652616009855 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 652616009856 Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514 652616009857 putative di-iron ligands [ion binding]; other site 652616009858 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 652616009859 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 652616009860 FAD binding pocket [chemical binding]; other site 652616009861 FAD binding motif [chemical binding]; other site 652616009862 phosphate binding motif [ion binding]; other site 652616009863 beta-alpha-beta structure motif; other site 652616009864 NAD(p) ribose binding residues [chemical binding]; other site 652616009865 NAD binding pocket [chemical binding]; other site 652616009866 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 652616009867 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 652616009868 catalytic loop [active] 652616009869 iron binding site [ion binding]; other site 652616009870 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 652616009871 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 652616009872 putative active site [active] 652616009873 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 652616009874 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 652616009875 dimer interface [polypeptide binding]; other site 652616009876 active site 652616009877 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 652616009878 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 652616009879 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616009880 PPE family; Region: PPE; pfam00823 652616009881 short chain dehydrogenase; Provisional; Region: PRK07831 652616009882 classical (c) SDRs; Region: SDR_c; cd05233 652616009883 NAD(P) binding site [chemical binding]; other site 652616009884 active site 652616009885 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 652616009886 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 652616009887 active site 652616009888 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 652616009889 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 652616009890 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 652616009891 acyl-activating enzyme (AAE) consensus motif; other site 652616009892 putative AMP binding site [chemical binding]; other site 652616009893 putative active site [active] 652616009894 putative CoA binding site [chemical binding]; other site 652616009895 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 652616009896 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 652616009897 active site 652616009898 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 652616009899 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 652616009900 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 652616009901 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 652616009902 active site 652616009903 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 652616009904 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 652616009905 active site 652616009906 aspartate aminotransferase; Provisional; Region: PRK05764 652616009907 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 652616009908 pyridoxal 5'-phosphate binding site [chemical binding]; other site 652616009909 homodimer interface [polypeptide binding]; other site 652616009910 catalytic residue [active] 652616009911 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 652616009912 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 652616009913 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 652616009914 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 652616009915 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 652616009916 active site 652616009917 Fe binding site [ion binding]; other site 652616009918 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 652616009919 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 652616009920 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 652616009921 Flavin binding site [chemical binding]; other site 652616009922 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 652616009923 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 652616009924 FAD binding pocket [chemical binding]; other site 652616009925 FAD binding motif [chemical binding]; other site 652616009926 phosphate binding motif [ion binding]; other site 652616009927 beta-alpha-beta structure motif; other site 652616009928 NAD(p) ribose binding residues [chemical binding]; other site 652616009929 NAD binding pocket [chemical binding]; other site 652616009930 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 652616009931 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 652616009932 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 652616009933 catalytic loop [active] 652616009934 iron binding site [ion binding]; other site 652616009935 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 652616009936 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 652616009937 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 652616009938 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 652616009939 active site 652616009940 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 652616009941 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 652616009942 Transcriptional regulators [Transcription]; Region: PurR; COG1609 652616009943 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 652616009944 DNA binding site [nucleotide binding] 652616009945 domain linker motif; other site 652616009946 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 652616009947 putative dimerization interface [polypeptide binding]; other site 652616009948 putative ligand binding site [chemical binding]; other site 652616009949 PknH-like extracellular domain; Region: PknH_C; pfam14032 652616009950 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 652616009951 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 652616009952 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 652616009953 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 652616009954 transmembrane helices; other site 652616009955 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 652616009956 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 652616009957 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 652616009958 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 652616009959 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 652616009960 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 652616009961 active site 652616009962 HIGH motif; other site 652616009963 nucleotide binding site [chemical binding]; other site 652616009964 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 652616009965 KMSKS motif; other site 652616009966 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 652616009967 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 652616009968 homotrimer interaction site [polypeptide binding]; other site 652616009969 zinc binding site [ion binding]; other site 652616009970 CDP-binding sites; other site 652616009971 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 652616009972 substrate binding site; other site 652616009973 dimer interface; other site 652616009974 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 652616009975 DNA repair protein RadA; Provisional; Region: PRK11823 652616009976 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 652616009977 Walker A motif; other site 652616009978 ATP binding site [chemical binding]; other site 652616009979 Walker B motif; other site 652616009980 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 652616009981 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 652616009982 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 652616009983 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 652616009984 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 652616009985 active site clefts [active] 652616009986 zinc binding site [ion binding]; other site 652616009987 dimer interface [polypeptide binding]; other site 652616009988 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 652616009989 endonuclease III; Region: ENDO3c; smart00478 652616009990 minor groove reading motif; other site 652616009991 helix-hairpin-helix signature motif; other site 652616009992 substrate binding pocket [chemical binding]; other site 652616009993 active site 652616009994 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 652616009995 PE family; Region: PE; pfam00934 652616009996 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 652616009997 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 652616009998 catalytic site [active] 652616009999 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 652616010000 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 652616010001 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 652616010002 Ami_2 domain; Region: Ami_2; smart00644 652616010003 amidase catalytic site [active] 652616010004 Zn binding residues [ion binding]; other site 652616010005 substrate binding site [chemical binding]; other site 652616010006 PE family; Region: PE; pfam00934 652616010007 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 652616010008 Clp amino terminal domain; Region: Clp_N; pfam02861 652616010009 Clp amino terminal domain; Region: Clp_N; pfam02861 652616010010 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 652616010011 Walker A motif; other site 652616010012 ATP binding site [chemical binding]; other site 652616010013 Walker B motif; other site 652616010014 arginine finger; other site 652616010015 UvrB/uvrC motif; Region: UVR; pfam02151 652616010016 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 652616010017 Walker A motif; other site 652616010018 ATP binding site [chemical binding]; other site 652616010019 Walker B motif; other site 652616010020 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 652616010021 Lsr2; Region: Lsr2; pfam11774 652616010022 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 652616010023 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 652616010024 dimer interface [polypeptide binding]; other site 652616010025 putative anticodon binding site; other site 652616010026 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 652616010027 motif 1; other site 652616010028 dimer interface [polypeptide binding]; other site 652616010029 active site 652616010030 motif 2; other site 652616010031 motif 3; other site 652616010032 pantothenate kinase; Reviewed; Region: PRK13318 652616010033 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 652616010034 tetramerization interface [polypeptide binding]; other site 652616010035 active site 652616010036 Pantoate-beta-alanine ligase; Region: PanC; cd00560 652616010037 pantoate--beta-alanine ligase; Region: panC; TIGR00018 652616010038 active site 652616010039 ATP-binding site [chemical binding]; other site 652616010040 pantoate-binding site; other site 652616010041 HXXH motif; other site 652616010042 Rossmann-like domain; Region: Rossmann-like; pfam10727 652616010043 Uncharacterized conserved protein [Function unknown]; Region: COG5495 652616010044 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 652616010045 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 652616010046 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 652616010047 catalytic center binding site [active] 652616010048 ATP binding site [chemical binding]; other site 652616010049 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 652616010050 homooctamer interface [polypeptide binding]; other site 652616010051 active site 652616010052 dihydropteroate synthase; Region: DHPS; TIGR01496 652616010053 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 652616010054 substrate binding pocket [chemical binding]; other site 652616010055 dimer interface [polypeptide binding]; other site 652616010056 inhibitor binding site; inhibition site 652616010057 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 652616010058 homodecamer interface [polypeptide binding]; other site 652616010059 GTP cyclohydrolase I; Provisional; Region: PLN03044 652616010060 active site 652616010061 putative catalytic site residues [active] 652616010062 zinc binding site [ion binding]; other site 652616010063 GTP-CH-I/GFRP interaction surface; other site 652616010064 FtsH Extracellular; Region: FtsH_ext; pfam06480 652616010065 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 652616010066 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 652616010067 Walker A motif; other site 652616010068 ATP binding site [chemical binding]; other site 652616010069 Walker B motif; other site 652616010070 arginine finger; other site 652616010071 Peptidase family M41; Region: Peptidase_M41; pfam01434 652616010072 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 652616010073 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 652616010074 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 652616010075 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 652616010076 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 652616010077 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 652616010078 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 652616010079 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616010080 PPE family; Region: PPE; pfam00823 652616010081 PE family; Region: PE; pfam00934 652616010082 Uncharacterized conserved protein [Function unknown]; Region: COG2968 652616010083 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 652616010084 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 652616010085 active site 652616010086 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 652616010087 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 652616010088 Ligand Binding Site [chemical binding]; other site 652616010089 Uncharacterized conserved protein [Function unknown]; Region: COG5282 652616010090 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 652616010091 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113 652616010092 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 652616010093 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 652616010094 dimer interface [polypeptide binding]; other site 652616010095 substrate binding site [chemical binding]; other site 652616010096 metal binding sites [ion binding]; metal-binding site 652616010097 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2899 652616010098 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 652616010099 Ligand binding site; other site 652616010100 Putative Catalytic site; other site 652616010101 DXD motif; other site 652616010102 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 652616010103 Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5285 652616010104 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 652616010105 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 652616010106 NAD(P) binding site [chemical binding]; other site 652616010107 active site 652616010108 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 652616010109 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 652616010110 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 652616010111 transposase; Provisional; Region: PRK06526 652616010112 IstB-like ATP binding protein; Region: IstB_IS21; pfam01695 652616010113 Walker B motif; other site 652616010114 Transposase, Mutator family; Region: Transposase_mut; pfam00872 652616010115 MULE transposase domain; Region: MULE; pfam10551 652616010116 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 652616010117 Fic/DOC family; Region: Fic; cl00960 652616010118 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 652616010119 DNA polymerase III subunit delta'; Validated; Region: PRK07940 652616010120 DNA polymerase III subunit delta'; Validated; Region: PRK08485 652616010121 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 652616010122 dimerization interface [polypeptide binding]; other site 652616010123 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 652616010124 cyclase homology domain; Region: CHD; cd07302 652616010125 nucleotidyl binding site; other site 652616010126 metal binding site [ion binding]; metal-binding site 652616010127 dimer interface [polypeptide binding]; other site 652616010128 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 652616010129 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 652616010130 active site 652616010131 interdomain interaction site; other site 652616010132 putative metal-binding site [ion binding]; other site 652616010133 nucleotide binding site [chemical binding]; other site 652616010134 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 652616010135 domain I; other site 652616010136 phosphate binding site [ion binding]; other site 652616010137 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 652616010138 domain II; other site 652616010139 domain III; other site 652616010140 nucleotide binding site [chemical binding]; other site 652616010141 DNA binding groove [nucleotide binding] 652616010142 catalytic site [active] 652616010143 domain IV; other site 652616010144 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 652616010145 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 652616010146 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 652616010147 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 652616010148 DNA-binding site [nucleotide binding]; DNA binding site 652616010149 RNA-binding motif; other site 652616010150 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 652616010151 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 652616010152 ATP binding site [chemical binding]; other site 652616010153 putative Mg++ binding site [ion binding]; other site 652616010154 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 652616010155 nucleotide binding region [chemical binding]; other site 652616010156 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 652616010157 PE family; Region: PE; pfam00934 652616010158 PE family; Region: PE; pfam00934 652616010159 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 652616010160 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 652616010161 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 652616010162 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 652616010163 Walker A motif; other site 652616010164 ATP binding site [chemical binding]; other site 652616010165 Walker B motif; other site 652616010166 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 652616010167 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 652616010168 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 652616010169 motif II; other site 652616010170 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 652616010171 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 652616010172 Walker A/P-loop; other site 652616010173 ATP binding site [chemical binding]; other site 652616010174 Q-loop/lid; other site 652616010175 ABC transporter signature motif; other site 652616010176 Walker B; other site 652616010177 D-loop; other site 652616010178 H-loop/switch region; other site 652616010179 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 652616010180 Walker A/P-loop; other site 652616010181 ATP binding site [chemical binding]; other site 652616010182 Q-loop/lid; other site 652616010183 ABC transporter signature motif; other site 652616010184 Walker B; other site 652616010185 D-loop; other site 652616010186 H-loop/switch region; other site 652616010187 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 652616010188 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 652616010189 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 652616010190 ABC-ATPase subunit interface; other site 652616010191 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 652616010192 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 652616010193 dimer interface [polypeptide binding]; other site 652616010194 conserved gate region; other site 652616010195 ABC-ATPase subunit interface; other site 652616010196 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 652616010197 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 652616010198 acetyl-CoA synthetase; Provisional; Region: PRK00174 652616010199 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 652616010200 active site 652616010201 CoA binding site [chemical binding]; other site 652616010202 acyl-activating enzyme (AAE) consensus motif; other site 652616010203 AMP binding site [chemical binding]; other site 652616010204 acetate binding site [chemical binding]; other site 652616010205 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 652616010206 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 652616010207 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 652616010208 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 652616010209 putative active site [active] 652616010210 putative CoA binding site [chemical binding]; other site 652616010211 nudix motif; other site 652616010212 metal binding site [ion binding]; metal-binding site 652616010213 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 652616010214 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 652616010215 catalytic residues [active] 652616010216 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 652616010217 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 652616010218 minor groove reading motif; other site 652616010219 helix-hairpin-helix signature motif; other site 652616010220 substrate binding pocket [chemical binding]; other site 652616010221 active site 652616010222 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 652616010223 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 652616010224 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 652616010225 ligand binding site [chemical binding]; other site 652616010226 flexible hinge region; other site 652616010227 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 652616010228 putative switch regulator; other site 652616010229 non-specific DNA interactions [nucleotide binding]; other site 652616010230 DNA binding site [nucleotide binding] 652616010231 sequence specific DNA binding site [nucleotide binding]; other site 652616010232 putative cAMP binding site [chemical binding]; other site 652616010233 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 652616010234 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 652616010235 homotrimer interaction site [polypeptide binding]; other site 652616010236 putative active site [active] 652616010237 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 652616010238 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 652616010239 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 652616010240 P loop; other site 652616010241 Nucleotide binding site [chemical binding]; other site 652616010242 DTAP/Switch II; other site 652616010243 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 652616010244 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 652616010245 DTAP/Switch II; other site 652616010246 Switch I; other site 652616010247 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 652616010248 Transcription factor WhiB; Region: Whib; pfam02467 652616010249 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 652616010250 Transglycosylase; Region: Transgly; pfam00912 652616010251 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 652616010252 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 652616010253 phosphodiesterase YaeI; Provisional; Region: PRK11340 652616010254 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 652616010255 putative active site [active] 652616010256 putative metal binding site [ion binding]; other site 652616010257 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 652616010258 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 652616010259 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 652616010260 catalytic residue [active] 652616010261 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 652616010262 Cytochrome P450; Region: p450; cl12078 652616010263 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 652616010264 anti sigma factor interaction site; other site 652616010265 regulatory phosphorylation site [posttranslational modification]; other site 652616010266 Uncharacterized conserved protein [Function unknown]; Region: COG1610 652616010267 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 652616010268 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 652616010269 MoxR-like ATPases [General function prediction only]; Region: COG0714 652616010270 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 652616010271 Walker A motif; other site 652616010272 ATP binding site [chemical binding]; other site 652616010273 Walker B motif; other site 652616010274 arginine finger; other site 652616010275 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 652616010276 Protein of unknown function DUF58; Region: DUF58; pfam01882 652616010277 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 652616010278 Predicted membrane protein/domain [Function unknown]; Region: COG1714 652616010279 glycerol kinase; Provisional; Region: glpK; PRK00047 652616010280 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 652616010281 nucleotide binding site [chemical binding]; other site 652616010282 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 652616010283 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 652616010284 Methyltransferase domain; Region: Methyltransf_23; pfam13489 652616010285 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 652616010286 S-adenosylmethionine binding site [chemical binding]; other site 652616010287 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 652616010288 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 652616010289 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 652616010290 catalytic residue [active] 652616010291 Uncharacterized conserved protein [Function unknown]; Region: COG4301 652616010292 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 652616010293 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 652616010294 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 652616010295 putative dimer interface [polypeptide binding]; other site 652616010296 putative active site [active] 652616010297 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 652616010298 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 652616010299 Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG3572 652616010300 PknH-like extracellular domain; Region: PknH_C; pfam14032 652616010301 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 652616010302 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 652616010303 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 652616010304 aspartate kinase; Reviewed; Region: PRK06635 652616010305 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 652616010306 putative nucleotide binding site [chemical binding]; other site 652616010307 putative catalytic residues [active] 652616010308 putative Mg ion binding site [ion binding]; other site 652616010309 putative aspartate binding site [chemical binding]; other site 652616010310 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 652616010311 putative allosteric regulatory site; other site 652616010312 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 652616010313 putative allosteric regulatory residue; other site 652616010314 2-isopropylmalate synthase; Validated; Region: PRK03739 652616010315 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 652616010316 active site 652616010317 catalytic residues [active] 652616010318 metal binding site [ion binding]; metal-binding site 652616010319 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 652616010320 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 652616010321 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 652616010322 active site 652616010323 catalytic site [active] 652616010324 substrate binding site [chemical binding]; other site 652616010325 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 652616010326 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 652616010327 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 652616010328 catalytic triad [active] 652616010329 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 652616010330 putative active site [active] 652616010331 recombination protein RecR; Reviewed; Region: recR; PRK00076 652616010332 RecR protein; Region: RecR; pfam02132 652616010333 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 652616010334 putative active site [active] 652616010335 putative metal-binding site [ion binding]; other site 652616010336 tetramer interface [polypeptide binding]; other site 652616010337 hypothetical protein; Validated; Region: PRK00153 652616010338 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 652616010339 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 652616010340 active site 652616010341 metal binding site [ion binding]; metal-binding site 652616010342 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 652616010343 hydrophobic ligand binding site; other site 652616010344 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 652616010345 FAD binding domain; Region: FAD_binding_4; pfam01565 652616010346 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 652616010347 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 652616010348 S-adenosylmethionine binding site [chemical binding]; other site 652616010349 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14952 652616010350 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 652616010351 Walker A motif; other site 652616010352 ATP binding site [chemical binding]; other site 652616010353 Walker B motif; other site 652616010354 arginine finger; other site 652616010355 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 652616010356 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 652616010357 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 652616010358 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 652616010359 catalytic residue [active] 652616010360 Cutinase; Region: Cutinase; pfam01083 652616010361 Cutinase; Region: Cutinase; pfam01083 652616010362 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 652616010363 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 652616010364 NAD(P) binding site [chemical binding]; other site 652616010365 active site 652616010366 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 652616010367 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 652616010368 putative NAD(P) binding site [chemical binding]; other site 652616010369 catalytic Zn binding site [ion binding]; other site 652616010370 Uncharacterized conserved protein [Function unknown]; Region: COG3349 652616010371 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 652616010372 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 652616010373 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 652616010374 putative substrate translocation pore; other site 652616010375 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 652616010376 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 652616010377 ligand binding site [chemical binding]; other site 652616010378 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 652616010379 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 652616010380 active site 652616010381 nucleophile elbow; other site 652616010382 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 652616010383 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 652616010384 FeS/SAM binding site; other site 652616010385 Methyltransferase domain; Region: Methyltransf_31; pfam13847 652616010386 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 652616010387 S-adenosylmethionine binding site [chemical binding]; other site 652616010388 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 652616010389 nucleotide binding site [chemical binding]; other site 652616010390 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 652616010391 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 652616010392 active site 652616010393 DNA binding site [nucleotide binding] 652616010394 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 652616010395 DNA binding site [nucleotide binding] 652616010396 Uncharacterized protein conserved in bacteria (DUF2330); Region: DUF2330; cl01827 652616010397 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_5; cd04662 652616010398 nudix motif; other site 652616010399 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 652616010400 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 652616010401 Uncharacterized conserved protein [Function unknown]; Region: COG1839 652616010402 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 652616010403 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 652616010404 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 652616010405 Uncharacterized conserved protein [Function unknown]; Region: COG2966 652616010406 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 652616010407 Uncharacterized conserved protein [Function unknown]; Region: COG3610 652616010408 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616010409 PPE family; Region: PPE; pfam00823 652616010410 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616010411 PPE family; Region: PPE; pfam00823 652616010412 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 652616010413 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 652616010414 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 652616010415 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 652616010416 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 652616010417 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 652616010418 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 652616010419 Soluble P-type ATPase [General function prediction only]; Region: COG4087 652616010420 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 652616010421 dimerization interface [polypeptide binding]; other site 652616010422 putative DNA binding site [nucleotide binding]; other site 652616010423 putative Zn2+ binding site [ion binding]; other site 652616010424 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; cl01467 652616010425 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 652616010426 DNA binding domain, excisionase family; Region: excise; TIGR01764 652616010427 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 652616010428 active site 652616010429 Int/Topo IB signature motif; other site 652616010430 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 652616010431 nucleoside/Zn binding site; other site 652616010432 dimer interface [polypeptide binding]; other site 652616010433 catalytic motif [active] 652616010434 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 652616010435 prephenate dehydrogenase; Validated; Region: PRK06545 652616010436 prephenate dehydrogenase; Validated; Region: PRK08507 652616010437 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3554 652616010438 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 652616010439 ABC-ATPase subunit interface; other site 652616010440 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 652616010441 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 652616010442 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 652616010443 Walker A/P-loop; other site 652616010444 ATP binding site [chemical binding]; other site 652616010445 Q-loop/lid; other site 652616010446 ABC transporter signature motif; other site 652616010447 Walker B; other site 652616010448 D-loop; other site 652616010449 H-loop/switch region; other site 652616010450 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 652616010451 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 652616010452 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 652616010453 putative active site [active] 652616010454 putative substrate binding site [chemical binding]; other site 652616010455 ATP binding site [chemical binding]; other site 652616010456 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 652616010457 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 652616010458 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 652616010459 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 652616010460 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 652616010461 dimerization interface [polypeptide binding]; other site 652616010462 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 652616010463 dimer interface [polypeptide binding]; other site 652616010464 phosphorylation site [posttranslational modification] 652616010465 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 652616010466 ATP binding site [chemical binding]; other site 652616010467 Mg2+ binding site [ion binding]; other site 652616010468 G-X-G motif; other site 652616010469 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 652616010470 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 652616010471 active site 652616010472 phosphorylation site [posttranslational modification] 652616010473 intermolecular recognition site; other site 652616010474 dimerization interface [polypeptide binding]; other site 652616010475 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 652616010476 DNA binding site [nucleotide binding] 652616010477 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 652616010478 active site 652616010479 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 652616010480 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 652616010481 SnoaL-like domain; Region: SnoaL_2; pfam12680 652616010482 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 652616010483 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 652616010484 pyridoxal 5'-phosphate binding site [chemical binding]; other site 652616010485 homodimer interface [polypeptide binding]; other site 652616010486 catalytic residue [active] 652616010487 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 652616010488 TIGR03086 family protein; Region: TIGR03086 652616010489 enoyl-CoA hydratase; Provisional; Region: PRK06142 652616010490 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 652616010491 substrate binding site [chemical binding]; other site 652616010492 oxyanion hole (OAH) forming residues; other site 652616010493 trimer interface [polypeptide binding]; other site 652616010494 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 652616010495 Beta-lactamase; Region: Beta-lactamase; pfam00144 652616010496 Domain of unknown function (DUF222); Region: DUF222; pfam02720 652616010497 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 652616010498 active site 652616010499 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 652616010500 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 652616010501 NAD(P) binding site [chemical binding]; other site 652616010502 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 652616010503 cysteine desulfurase family protein, VC1184 subfamily; Region: am_tr_V_VC1184; TIGR01976 652616010504 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 652616010505 catalytic residue [active] 652616010506 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 652616010507 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 652616010508 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 652616010509 Walker A/P-loop; other site 652616010510 ATP binding site [chemical binding]; other site 652616010511 Q-loop/lid; other site 652616010512 ABC transporter signature motif; other site 652616010513 Walker B; other site 652616010514 D-loop; other site 652616010515 H-loop/switch region; other site 652616010516 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 652616010517 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 652616010518 active site 652616010519 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 652616010520 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 652616010521 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 652616010522 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 652616010523 NAD binding site [chemical binding]; other site 652616010524 substrate binding site [chemical binding]; other site 652616010525 active site 652616010526 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 652616010527 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 652616010528 active site 652616010529 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 652616010530 Peptidase family M23; Region: Peptidase_M23; pfam01551 652616010531 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 652616010532 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 652616010533 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05892 652616010534 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 652616010535 Predicted membrane protein [Function unknown]; Region: COG2246 652616010536 GtrA-like protein; Region: GtrA; pfam04138 652616010537 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 652616010538 FAD binding domain; Region: FAD_binding_4; pfam01565 652616010539 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 652616010540 short chain dehydrogenase; Provisional; Region: PRK07904 652616010541 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 652616010542 NAD(P) binding site [chemical binding]; other site 652616010543 active site 652616010544 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 652616010545 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 652616010546 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 652616010547 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 652616010548 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 652616010549 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 652616010550 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 652616010551 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 652616010552 FAD binding site [chemical binding]; other site 652616010553 substrate binding site [chemical binding]; other site 652616010554 catalytic residues [active] 652616010555 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 652616010556 Transposase; Region: DDE_Tnp_ISL3; pfam01610 652616010557 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 652616010558 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 652616010559 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 652616010560 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 652616010561 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 652616010562 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 652616010563 active site 652616010564 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 652616010565 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 652616010566 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 652616010567 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 652616010568 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 652616010569 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 652616010570 acyl-activating enzyme (AAE) consensus motif; other site 652616010571 active site 652616010572 Cutinase; Region: Cutinase; pfam01083 652616010573 Predicted esterase [General function prediction only]; Region: COG0627 652616010574 Putative esterase; Region: Esterase; pfam00756 652616010575 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 652616010576 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 652616010577 active site 652616010578 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 652616010579 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 652616010580 active site 652616010581 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 652616010582 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 652616010583 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 652616010584 UDP-galactopyranose mutase; Region: GLF; pfam03275 652616010585 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 652616010586 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 652616010587 amidase catalytic site [active] 652616010588 Zn binding residues [ion binding]; other site 652616010589 substrate binding site [chemical binding]; other site 652616010590 LGFP repeat; Region: LGFP; pfam08310 652616010591 PE family; Region: PE; pfam00934 652616010592 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 652616010593 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 652616010594 active site 652616010595 motif I; other site 652616010596 motif II; other site 652616010597 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 652616010598 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 652616010599 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 652616010600 putative acyl-acceptor binding pocket; other site 652616010601 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 652616010602 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 652616010603 putative acyl-acceptor binding pocket; other site 652616010604 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 652616010605 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 652616010606 putative acyl-acceptor binding pocket; other site 652616010607 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 652616010608 Phosphotransferase enzyme family; Region: APH; pfam01636 652616010609 active site 652616010610 ATP binding site [chemical binding]; other site 652616010611 antibiotic binding site [chemical binding]; other site 652616010612 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 652616010613 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 652616010614 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 652616010615 iron-sulfur cluster [ion binding]; other site 652616010616 [2Fe-2S] cluster binding site [ion binding]; other site 652616010617 Condensation domain; Region: Condensation; pfam00668 652616010618 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 652616010619 PE-PPE domain; Region: PE-PPE; pfam08237 652616010620 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 652616010621 peptide synthase; Provisional; Region: PRK12316 652616010622 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 652616010623 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 652616010624 active site 652616010625 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 652616010626 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 652616010627 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 652616010628 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 652616010629 Enoylreductase; Region: PKS_ER; smart00829 652616010630 NAD(P) binding site [chemical binding]; other site 652616010631 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 652616010632 KR domain; Region: KR; pfam08659 652616010633 putative NADP binding site [chemical binding]; other site 652616010634 active site 652616010635 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 652616010636 acyl-CoA synthetase; Validated; Region: PRK05850 652616010637 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 652616010638 acyl-activating enzyme (AAE) consensus motif; other site 652616010639 active site 652616010640 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 652616010641 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 652616010642 Probable transposase; Region: OrfB_IS605; pfam01385 652616010643 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 652616010644 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 652616010645 catalytic residues [active] 652616010646 catalytic nucleophile [active] 652616010647 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 652616010648 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 652616010649 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 652616010650 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 652616010651 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 652616010652 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 652616010653 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 652616010654 Cupin domain; Region: Cupin_2; cl17218 652616010655 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 652616010656 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 652616010657 seryl-tRNA synthetase; Provisional; Region: PRK05431 652616010658 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 652616010659 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 652616010660 dimer interface [polypeptide binding]; other site 652616010661 active site 652616010662 motif 1; other site 652616010663 motif 2; other site 652616010664 motif 3; other site 652616010665 Septum formation; Region: Septum_form; pfam13845 652616010666 Septum formation; Region: Septum_form; pfam13845 652616010667 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 652616010668 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 652616010669 catalytic core [active] 652616010670 prephenate dehydratase; Provisional; Region: PRK11898 652616010671 Prephenate dehydratase; Region: PDT; pfam00800 652616010672 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 652616010673 putative L-Phe binding site [chemical binding]; other site 652616010674 Transcriptional regulator [Transcription]; Region: LytR; COG1316 652616010675 Ferritin-like domain; Region: Ferritin; pfam00210 652616010676 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 652616010677 ferroxidase diiron center [ion binding]; other site 652616010678 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 652616010679 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 652616010680 putative active site [active] 652616010681 catalytic site [active] 652616010682 putative metal binding site [ion binding]; other site 652616010683 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 652616010684 Transposase; Region: DEDD_Tnp_IS110; pfam01548 652616010685 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 652616010686 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 652616010687 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 652616010688 Predicted membrane protein [Function unknown]; Region: COG2119 652616010689 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 652616010690 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 652616010691 Fimbrial protein; Region: Fimbrial; cl01416 652616010692 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 652616010693 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 652616010694 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 652616010695 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 652616010696 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 652616010697 hypothetical protein; Provisional; Region: PRK07945 652616010698 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 652616010699 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 652616010700 active site 652616010701 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 652616010702 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 652616010703 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 652616010704 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 652616010705 active site 652616010706 dimer interface [polypeptide binding]; other site 652616010707 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 652616010708 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 652616010709 active site 652616010710 FMN binding site [chemical binding]; other site 652616010711 substrate binding site [chemical binding]; other site 652616010712 3Fe-4S cluster binding site [ion binding]; other site 652616010713 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 652616010714 domain interface; other site 652616010715 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 652616010716 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 652616010717 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 652616010718 EspG family; Region: ESX-1_EspG; pfam14011 652616010719 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 652616010720 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 652616010721 Walker A motif; other site 652616010722 ATP binding site [chemical binding]; other site 652616010723 Walker B motif; other site 652616010724 arginine finger; other site 652616010725 Protein of unknown function (DUF690); Region: DUF690; pfam05108 652616010726 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 652616010727 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 652616010728 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 652616010729 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 652616010730 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 652616010731 PE family; Region: PE; pfam00934 652616010732 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 652616010733 PPE family; Region: PPE; pfam00823 652616010734 Proteins of 100 residues with WXG; Region: WXG100; cl02005 652616010735 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 652616010736 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 652616010737 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 652616010738 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 652616010739 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 652616010740 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 652616010741 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 652616010742 active site 652616010743 catalytic residues [active] 652616010744 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 652616010745 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 652616010746 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 652616010747 Walker A motif; other site 652616010748 ATP binding site [chemical binding]; other site 652616010749 Walker B motif; other site 652616010750 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 652616010751 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 652616010752 active site 652616010753 catalytic residues [active] 652616010754 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 652616010755 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 652616010756 EspG family; Region: ESX-1_EspG; pfam14011 652616010757 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 652616010758 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 652616010759 PPE family; Region: PPE; pfam00823 652616010760 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 652616010761 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 652616010762 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 652616010763 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 652616010764 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 652616010765 Protein of unknown function (DUF690); Region: DUF690; pfam05108 652616010766 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 652616010767 N-acetyl-D-glucosamine binding site [chemical binding]; other site 652616010768 catalytic residue [active] 652616010769 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 652616010770 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 652616010771 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 652616010772 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 652616010773 active site 652616010774 NTP binding site [chemical binding]; other site 652616010775 metal binding triad [ion binding]; metal-binding site 652616010776 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 652616010777 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 652616010778 Zn2+ binding site [ion binding]; other site 652616010779 Mg2+ binding site [ion binding]; other site 652616010780 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 652616010781 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 652616010782 active site 652616010783 Ap6A binding site [chemical binding]; other site 652616010784 nudix motif; other site 652616010785 metal binding site [ion binding]; metal-binding site 652616010786 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 652616010787 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 652616010788 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 652616010789 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 652616010790 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 652616010791 DNA binding residues [nucleotide binding] 652616010792 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 652616010793 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 652616010794 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 652616010795 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 652616010796 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 652616010797 catalytic residues [active] 652616010798 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 652616010799 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 652616010800 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 652616010801 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 652616010802 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 652616010803 active site 652616010804 metal binding site [ion binding]; metal-binding site 652616010805 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 652616010806 ParB-like nuclease domain; Region: ParB; smart00470 652616010807 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 652616010808 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 652616010809 P-loop; other site 652616010810 Magnesium ion binding site [ion binding]; other site 652616010811 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 652616010812 Magnesium ion binding site [ion binding]; other site 652616010813 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 652616010814 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 652616010815 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 652616010816 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 652616010817 G-X-X-G motif; other site 652616010818 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 652616010819 RxxxH motif; other site 652616010820 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 652616010821 Ribonuclease P; Region: Ribonuclease_P; cl00457