-- dump date 20140619_154515 -- class Genbank::misc_feature -- table misc_feature_note -- id note 336982000001 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 336982000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 336982000003 Walker A motif; other site 336982000004 ATP binding site [chemical binding]; other site 336982000005 Walker B motif; other site 336982000006 arginine finger; other site 336982000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 336982000008 DnaA box-binding interface [nucleotide binding]; other site 336982000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 336982000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 336982000011 putative DNA binding surface [nucleotide binding]; other site 336982000012 dimer interface [polypeptide binding]; other site 336982000013 beta-clamp/clamp loader binding surface; other site 336982000014 beta-clamp/translesion DNA polymerase binding surface; other site 336982000015 recF protein; Region: recf; TIGR00611 336982000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 336982000017 Walker A/P-loop; other site 336982000018 ATP binding site [chemical binding]; other site 336982000019 Q-loop/lid; other site 336982000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 336982000021 ABC transporter signature motif; other site 336982000022 Walker B; other site 336982000023 D-loop; other site 336982000024 H-loop/switch region; other site 336982000025 hypothetical protein; Provisional; Region: PRK03195 336982000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 336982000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 336982000028 Mg2+ binding site [ion binding]; other site 336982000029 G-X-G motif; other site 336982000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 336982000031 anchoring element; other site 336982000032 dimer interface [polypeptide binding]; other site 336982000033 ATP binding site [chemical binding]; other site 336982000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 336982000035 active site 336982000036 putative metal-binding site [ion binding]; other site 336982000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 336982000038 DNA gyrase subunit A; Validated; Region: PRK05560 336982000039 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 336982000040 CAP-like domain; other site 336982000041 active site 336982000042 primary dimer interface [polypeptide binding]; other site 336982000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 336982000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 336982000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 336982000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 336982000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 336982000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 336982000049 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 336982000050 Protein of unknown function (DUF2562); Region: DUF2562; pfam10814 336982000051 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 336982000052 active site 336982000053 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 336982000054 putative septation inhibitor protein; Reviewed; Region: PRK00159 336982000055 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 336982000056 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 336982000057 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 336982000058 Glutamine amidotransferase class-I; Region: GATase; pfam00117 336982000059 glutamine binding [chemical binding]; other site 336982000060 catalytic triad [active] 336982000061 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 336982000062 Catalytic domain of Protein Kinases; Region: PKc; cd00180 336982000063 active site 336982000064 ATP binding site [chemical binding]; other site 336982000065 substrate binding site [chemical binding]; other site 336982000066 activation loop (A-loop); other site 336982000067 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 336982000068 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 336982000069 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 336982000070 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 336982000071 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 336982000072 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 336982000073 Catalytic domain of Protein Kinases; Region: PKc; cd00180 336982000074 active site 336982000075 ATP binding site [chemical binding]; other site 336982000076 substrate binding site [chemical binding]; other site 336982000077 activation loop (A-loop); other site 336982000078 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 336982000079 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 336982000080 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 336982000081 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 336982000082 active site 336982000083 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 336982000084 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 336982000085 phosphopeptide binding site; other site 336982000086 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 336982000087 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 336982000088 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 336982000089 phosphopeptide binding site; other site 336982000090 Nitronate monooxygenase; Region: NMO; pfam03060 336982000091 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 336982000092 FMN binding site [chemical binding]; other site 336982000093 substrate binding site [chemical binding]; other site 336982000094 putative catalytic residue [active] 336982000095 Transcription factor WhiB; Region: Whib; pfam02467 336982000096 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 336982000097 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 336982000098 non-specific DNA binding site [nucleotide binding]; other site 336982000099 salt bridge; other site 336982000100 sequence-specific DNA binding site [nucleotide binding]; other site 336982000101 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 336982000102 NlpC/P60 family; Region: NLPC_P60; pfam00877 336982000103 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 336982000104 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 336982000105 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 336982000106 Protein of unknown function (DUF2694); Region: DUF2694; pfam10904 336982000107 Protein of unknown function (DUF2710); Region: DUF2710; pfam10921 336982000108 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 336982000109 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 336982000110 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 336982000111 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 336982000112 catalytic residue [active] 336982000113 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 336982000114 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 336982000115 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 336982000116 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 336982000117 acyl-activating enzyme (AAE) consensus motif; other site 336982000118 active site 336982000119 TIGR03084 family protein; Region: TIGR03084 336982000120 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 336982000121 Wyosine base formation; Region: Wyosine_form; pfam08608 336982000122 H+ Antiporter protein; Region: 2A0121; TIGR00900 336982000123 hypothetical protein; Validated; Region: PRK00228 336982000124 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 336982000125 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 336982000126 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 336982000127 active site 336982000128 HIGH motif; other site 336982000129 nucleotide binding site [chemical binding]; other site 336982000130 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 336982000131 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 336982000132 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 336982000133 active site 336982000134 KMSKS motif; other site 336982000135 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 336982000136 tRNA binding surface [nucleotide binding]; other site 336982000137 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 336982000138 MarR family; Region: MarR; pfam01047 336982000139 Transcriptional regulators [Transcription]; Region: FadR; COG2186 336982000140 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 336982000141 DNA-binding site [nucleotide binding]; DNA binding site 336982000142 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 336982000143 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 336982000144 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 336982000145 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 336982000146 inositol 1-phosphate synthase, Actinobacterial type; Region: mycothiol_INO1; TIGR03450 336982000147 Predicted transcriptional regulators [Transcription]; Region: COG1695 336982000148 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 336982000149 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 336982000150 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 336982000151 Transglycosylase; Region: Transgly; pfam00912 336982000152 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 336982000153 Predicted integral membrane protein [Function unknown]; Region: COG5650 336982000154 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 336982000155 conserved cys residue [active] 336982000156 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 336982000157 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 336982000158 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 336982000159 dimer interface [polypeptide binding]; other site 336982000160 ssDNA binding site [nucleotide binding]; other site 336982000161 tetramer (dimer of dimers) interface [polypeptide binding]; other site 336982000162 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 336982000163 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 336982000164 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 336982000165 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 336982000166 replicative DNA helicase; Validated; Region: PRK07773 336982000167 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 336982000168 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 336982000169 Walker A motif; other site 336982000170 ATP binding site [chemical binding]; other site 336982000171 Walker B motif; other site 336982000172 DNA binding loops [nucleotide binding] 336982000173 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 336982000174 protein-splicing catalytic site; other site 336982000175 thioester formation/cholesterol transfer; other site 336982000176 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 336982000177 protein-splicing catalytic site; other site 336982000178 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 336982000179 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 336982000180 ADP-ribose binding site [chemical binding]; other site 336982000181 Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1 [General function prediction only]; Region: COG2110 336982000182 Cellobiohydrolase A (1,4-beta-cellobiosidase A) [Carbohydrate transport and metabolism]; Region: CelA; COG5297 336982000183 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 336982000184 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 336982000185 FAD binding domain; Region: FAD_binding_4; pfam01565 336982000186 Berberine and berberine like; Region: BBE; pfam08031 336982000187 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 336982000188 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 336982000189 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 336982000190 homotetrameric interface [polypeptide binding]; other site 336982000191 putative active site [active] 336982000192 metal binding site [ion binding]; metal-binding site 336982000193 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 336982000194 Monomeric isocitrate dehydrogenase; Region: IDH; pfam03971 336982000195 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982000196 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982000197 short chain dehydrogenase; Provisional; Region: PRK06197 336982000198 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 336982000199 putative NAD(P) binding site [chemical binding]; other site 336982000200 active site 336982000201 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 336982000202 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 336982000203 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 336982000204 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 336982000205 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 336982000206 dimer interface [polypeptide binding]; other site 336982000207 active site 336982000208 glycine-pyridoxal phosphate binding site [chemical binding]; other site 336982000209 folate binding site [chemical binding]; other site 336982000210 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 336982000211 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 336982000212 putative NTP binding site [chemical binding]; other site 336982000213 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 336982000214 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 336982000215 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 336982000216 Walker A/P-loop; other site 336982000217 ATP binding site [chemical binding]; other site 336982000218 Q-loop/lid; other site 336982000219 ABC transporter signature motif; other site 336982000220 Walker B; other site 336982000221 D-loop; other site 336982000222 H-loop/switch region; other site 336982000223 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 336982000224 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 336982000225 ligand binding site [chemical binding]; other site 336982000226 flexible hinge region; other site 336982000227 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 336982000228 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 336982000229 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 336982000230 active site 336982000231 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 336982000232 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 336982000233 pyridoxal 5'-phosphate binding site [chemical binding]; other site 336982000234 homodimer interface [polypeptide binding]; other site 336982000235 catalytic residue [active] 336982000236 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 336982000237 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982000238 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982000239 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 336982000240 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 336982000241 dimerization interface [polypeptide binding]; other site 336982000242 putative DNA binding site [nucleotide binding]; other site 336982000243 putative Zn2+ binding site [ion binding]; other site 336982000244 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 336982000245 hydrogenase 4 subunit B; Validated; Region: PRK06521 336982000246 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 336982000247 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 336982000248 NADH dehydrogenase; Region: NADHdh; cl00469 336982000249 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; COG4237 336982000250 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 336982000251 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 336982000252 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 336982000253 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 336982000254 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 336982000255 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 336982000256 putative hydrophobic ligand binding site [chemical binding]; other site 336982000257 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 336982000258 S-adenosylmethionine binding site [chemical binding]; other site 336982000259 Predicted membrane protein [Function unknown]; Region: COG3305 336982000260 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 336982000261 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 336982000262 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 336982000263 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 336982000264 metal-binding site [ion binding] 336982000265 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 336982000266 Soluble P-type ATPase [General function prediction only]; Region: COG4087 336982000267 Predicted integral membrane protein [Function unknown]; Region: COG5660 336982000268 Putative zinc-finger; Region: zf-HC2; pfam13490 336982000269 Domain of unknown function (DUF222); Region: DUF222; pfam02720 336982000270 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 336982000271 active site 336982000272 Domain of unknown function (DUF222); Region: DUF222; pfam02720 336982000273 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982000274 PPE family; Region: PPE; pfam00823 336982000275 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 336982000276 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 336982000277 FcoT-like thioesterase domain; Region: FcoT; pfam10862 336982000278 acyl-CoA synthetase; Validated; Region: PRK05857 336982000279 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 336982000280 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 336982000281 acyl-activating enzyme (AAE) consensus motif; other site 336982000282 acyl-activating enzyme (AAE) consensus motif; other site 336982000283 AMP binding site [chemical binding]; other site 336982000284 active site 336982000285 CoA binding site [chemical binding]; other site 336982000286 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 336982000287 AMP-binding enzyme; Region: AMP-binding; pfam00501 336982000288 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 336982000289 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 336982000290 acyl-activating enzyme (AAE) consensus motif; other site 336982000291 acyl-activating enzyme (AAE) consensus motif; other site 336982000292 active site 336982000293 AMP binding site [chemical binding]; other site 336982000294 CoA binding site [chemical binding]; other site 336982000295 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 336982000296 Condensation domain; Region: Condensation; pfam00668 336982000297 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 336982000298 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 336982000299 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 336982000300 acyl-activating enzyme (AAE) consensus motif; other site 336982000301 AMP binding site [chemical binding]; other site 336982000302 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 336982000303 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 336982000304 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 336982000305 putative NAD(P) binding site [chemical binding]; other site 336982000306 active site 336982000307 putative substrate binding site [chemical binding]; other site 336982000308 Predicted membrane protein [Function unknown]; Region: COG3336 336982000309 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 336982000310 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 336982000311 metal-binding site [ion binding] 336982000312 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 336982000313 Soluble P-type ATPase [General function prediction only]; Region: COG4087 336982000314 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 336982000315 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 336982000316 ligand binding site [chemical binding]; other site 336982000317 flexible hinge region; other site 336982000318 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 336982000319 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 336982000320 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 336982000321 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 336982000322 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 336982000323 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 336982000324 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 336982000325 motif II; other site 336982000326 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 336982000327 PE family; Region: PE; pfam00934 336982000328 B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; Region: BBOX; cl00034 336982000329 Rhomboid family; Region: Rhomboid; pfam01694 336982000330 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 336982000331 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 336982000332 active site 336982000333 catalytic triad [active] 336982000334 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 336982000335 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 336982000336 NADP-binding site; other site 336982000337 homotetramer interface [polypeptide binding]; other site 336982000338 substrate binding site [chemical binding]; other site 336982000339 homodimer interface [polypeptide binding]; other site 336982000340 active site 336982000341 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 336982000342 dimer interface [polypeptide binding]; other site 336982000343 active site 336982000344 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 336982000345 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 336982000346 active site 336982000347 motif I; other site 336982000348 motif II; other site 336982000349 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 336982000350 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 336982000351 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 336982000352 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 336982000353 Transcriptional regulator [Transcription]; Region: LysR; COG0583 336982000354 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 336982000355 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 336982000356 dimerization interface [polypeptide binding]; other site 336982000357 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 336982000358 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 336982000359 PYR/PP interface [polypeptide binding]; other site 336982000360 dimer interface [polypeptide binding]; other site 336982000361 TPP binding site [chemical binding]; other site 336982000362 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 336982000363 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 336982000364 TPP-binding site; other site 336982000365 dimer interface [polypeptide binding]; other site 336982000366 acyl-CoA synthetase; Validated; Region: PRK05852 336982000367 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 336982000368 Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926 336982000369 acyl-activating enzyme (AAE) consensus motif; other site 336982000370 acyl-activating enzyme (AAE) consensus motif; other site 336982000371 putative AMP binding site [chemical binding]; other site 336982000372 putative active site [active] 336982000373 putative CoA binding site [chemical binding]; other site 336982000374 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 336982000375 elongation factor G; Reviewed; Region: PRK12740 336982000376 G1 box; other site 336982000377 putative GEF interaction site [polypeptide binding]; other site 336982000378 GTP/Mg2+ binding site [chemical binding]; other site 336982000379 Switch I region; other site 336982000380 G2 box; other site 336982000381 G3 box; other site 336982000382 Switch II region; other site 336982000383 G4 box; other site 336982000384 G5 box; other site 336982000385 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 336982000386 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 336982000387 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 336982000388 PPOX class probable F420-dependent enzyme, Rv0121 family; Region: Rv0121_F420; TIGR03668 336982000389 PE family; Region: PE; pfam00934 336982000390 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 336982000391 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 336982000392 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 336982000393 trehalose synthase; Region: treS_nterm; TIGR02456 336982000394 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 336982000395 active site 336982000396 catalytic site [active] 336982000397 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 336982000398 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 336982000399 Predicted membrane protein [Function unknown]; Region: COG3619 336982000400 Predicted esterase [General function prediction only]; Region: COG0627 336982000401 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 336982000402 putative active site [active] 336982000403 putative catalytic site [active] 336982000404 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 336982000405 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 336982000406 active site 336982000407 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 336982000408 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 336982000409 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 336982000410 Coenzyme A binding pocket [chemical binding]; other site 336982000411 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 336982000412 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 336982000413 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982000414 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982000415 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 336982000416 Cytochrome P450; Region: p450; cl12078 336982000417 methionine sulfoxide reductase A; Provisional; Region: PRK14054 336982000418 SnoaL-like domain; Region: SnoaL_2; pfam12680 336982000419 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 336982000420 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982000421 NAD(P) binding site [chemical binding]; other site 336982000422 active site 336982000423 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 336982000424 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 336982000425 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 336982000426 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 336982000427 minor groove reading motif; other site 336982000428 helix-hairpin-helix signature motif; other site 336982000429 active site 336982000430 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 336982000431 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 336982000432 Cl- selectivity filter; other site 336982000433 Cl- binding residues [ion binding]; other site 336982000434 pore gating glutamate residue; other site 336982000435 dimer interface [polypeptide binding]; other site 336982000436 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982000437 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982000438 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 336982000439 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 336982000440 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 336982000441 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 336982000442 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 336982000443 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 336982000444 NAD(P) binding site [chemical binding]; other site 336982000445 catalytic residues [active] 336982000446 short chain dehydrogenase; Provisional; Region: PRK07791 336982000447 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 336982000448 NAD binding site [chemical binding]; other site 336982000449 homodimer interface [polypeptide binding]; other site 336982000450 active site 336982000451 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 336982000452 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 336982000453 NAD(P) binding site [chemical binding]; other site 336982000454 PE family; Region: PE; pfam00934 336982000455 PE-PPE domain; Region: PE-PPE; pfam08237 336982000456 PE-PPE domain; Region: PE-PPE; pfam08237 336982000457 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 336982000458 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 336982000459 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 336982000460 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 336982000461 FAD binding site [chemical binding]; other site 336982000462 substrate binding site [chemical binding]; other site 336982000463 catalytic base [active] 336982000464 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 336982000465 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 336982000466 ligand binding site [chemical binding]; other site 336982000467 homodimer interface [polypeptide binding]; other site 336982000468 NAD(P) binding site [chemical binding]; other site 336982000469 trimer interface B [polypeptide binding]; other site 336982000470 trimer interface A [polypeptide binding]; other site 336982000471 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 336982000472 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 336982000473 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 336982000474 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 336982000475 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982000476 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982000477 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 336982000478 PE family; Region: PE; pfam00934 336982000479 PE-PPE domain; Region: PE-PPE; pfam08237 336982000480 PE family; Region: PE; pfam00934 336982000481 PE-PPE domain; Region: PE-PPE; pfam08237 336982000482 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 336982000483 FAD binding domain; Region: FAD_binding_4; pfam01565 336982000484 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 336982000485 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 336982000486 NAD(P) binding site [chemical binding]; other site 336982000487 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 336982000488 active site 336982000489 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 336982000490 putative hydrophobic ligand binding site [chemical binding]; other site 336982000491 Transcriptional regulators [Transcription]; Region: GntR; COG1802 336982000492 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 336982000493 DNA-binding site [nucleotide binding]; DNA binding site 336982000494 FCD domain; Region: FCD; pfam07729 336982000495 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786 336982000496 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 336982000497 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 336982000498 acyl-activating enzyme (AAE) consensus motif; other site 336982000499 acyl-activating enzyme (AAE) consensus motif; other site 336982000500 putative AMP binding site [chemical binding]; other site 336982000501 putative active site [active] 336982000502 putative CoA binding site [chemical binding]; other site 336982000503 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 336982000504 Permease; Region: Permease; pfam02405 336982000505 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 336982000506 Permease; Region: Permease; pfam02405 336982000507 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 336982000508 mce related protein; Region: MCE; pfam02470 336982000509 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 336982000510 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 336982000511 mce related protein; Region: MCE; pfam02470 336982000512 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 336982000513 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 336982000514 mce related protein; Region: MCE; pfam02470 336982000515 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 336982000516 mce related protein; Region: MCE; pfam02470 336982000517 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 336982000518 mce related protein; Region: MCE; pfam02470 336982000519 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 336982000520 mce related protein; Region: MCE; pfam02470 336982000521 RDD family; Region: RDD; pfam06271 336982000522 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 336982000523 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 336982000524 Predicted membrane protein [Function unknown]; Region: COG1511 336982000525 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 336982000526 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 336982000527 Pirin-related protein [General function prediction only]; Region: COG1741 336982000528 Pirin; Region: Pirin; pfam02678 336982000529 RNA polymerase factor sigma-70; Validated; Region: PRK08241 336982000530 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 336982000531 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 336982000532 DNA binding residues [nucleotide binding] 336982000533 SnoaL-like domain; Region: SnoaL_2; pfam12680 336982000534 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 336982000535 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 336982000536 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 336982000537 putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185 336982000538 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 336982000539 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 336982000540 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 336982000541 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 336982000542 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 336982000543 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 336982000544 S-adenosylmethionine binding site [chemical binding]; other site 336982000545 SPW repeat; Region: SPW; pfam03779 336982000546 SPW repeat; Region: SPW; pfam03779 336982000547 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 336982000548 6-phosphogluconate dehydratase; Region: edd; TIGR01196 336982000549 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 336982000550 putative homodimer interface [polypeptide binding]; other site 336982000551 putative homotetramer interface [polypeptide binding]; other site 336982000552 putative allosteric switch controlling residues; other site 336982000553 putative metal binding site [ion binding]; other site 336982000554 putative homodimer-homodimer interface [polypeptide binding]; other site 336982000555 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 336982000556 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 336982000557 putative substrate translocation pore; other site 336982000558 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 336982000559 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 336982000560 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 336982000561 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 336982000562 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 336982000563 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 336982000564 Walker A/P-loop; other site 336982000565 ATP binding site [chemical binding]; other site 336982000566 Q-loop/lid; other site 336982000567 ABC transporter signature motif; other site 336982000568 Walker B; other site 336982000569 D-loop; other site 336982000570 H-loop/switch region; other site 336982000571 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 336982000572 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 336982000573 Walker A/P-loop; other site 336982000574 ATP binding site [chemical binding]; other site 336982000575 Q-loop/lid; other site 336982000576 ABC transporter signature motif; other site 336982000577 Walker B; other site 336982000578 D-loop; other site 336982000579 H-loop/switch region; other site 336982000580 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 336982000581 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 336982000582 dimerization interface [polypeptide binding]; other site 336982000583 DNA binding residues [nucleotide binding] 336982000584 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982000585 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982000586 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 336982000587 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 336982000588 putative [Fe4-S4] binding site [ion binding]; other site 336982000589 putative molybdopterin cofactor binding site [chemical binding]; other site 336982000590 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 336982000591 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 336982000592 putative molybdopterin cofactor binding site; other site 336982000593 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 336982000594 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 336982000595 active site 336982000596 Zn binding site [ion binding]; other site 336982000597 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 336982000598 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 336982000599 Predicted integral membrane protein [Function unknown]; Region: COG0392 336982000600 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 336982000601 Domain of unknown function DUF20; Region: UPF0118; pfam01594 336982000602 MMPL family; Region: MMPL; pfam03176 336982000603 MMPL family; Region: MMPL; pfam03176 336982000604 LabA_like proteins; Region: LabA_like; cd06167 336982000605 putative metal binding site [ion binding]; other site 336982000606 Putative methyltransferase; Region: Methyltransf_4; pfam02390 336982000607 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 336982000608 active site 336982000609 substrate-binding site [chemical binding]; other site 336982000610 metal-binding site [ion binding] 336982000611 GTP binding site [chemical binding]; other site 336982000612 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 336982000613 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 336982000614 active site 336982000615 (T/H)XGH motif; other site 336982000616 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 336982000617 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 336982000618 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 336982000619 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 336982000620 FeS/SAM binding site; other site 336982000621 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 336982000622 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 336982000623 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 336982000624 acyl-activating enzyme (AAE) consensus motif; other site 336982000625 acyl-activating enzyme (AAE) consensus motif; other site 336982000626 putative AMP binding site [chemical binding]; other site 336982000627 putative active site [active] 336982000628 putative CoA binding site [chemical binding]; other site 336982000629 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 336982000630 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 336982000631 active site 336982000632 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 336982000633 putative active site [active] 336982000634 putative catalytic site [active] 336982000635 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 336982000636 active site 2 [active] 336982000637 active site 1 [active] 336982000638 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 336982000639 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 336982000640 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 336982000641 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321 336982000642 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 336982000643 Moco binding site; other site 336982000644 metal coordination site [ion binding]; other site 336982000645 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 336982000646 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 336982000647 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 336982000648 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 336982000649 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 336982000650 enoyl-CoA hydratase; Provisional; Region: PRK08252 336982000651 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 336982000652 substrate binding site [chemical binding]; other site 336982000653 oxyanion hole (OAH) forming residues; other site 336982000654 trimer interface [polypeptide binding]; other site 336982000655 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 336982000656 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 336982000657 NAD binding site [chemical binding]; other site 336982000658 catalytic residues [active] 336982000659 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 336982000660 S-adenosylmethionine binding site [chemical binding]; other site 336982000661 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 336982000662 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 336982000663 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 336982000664 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 336982000665 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 336982000666 putative active site [active] 336982000667 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 336982000668 active site 336982000669 substrate binding pocket [chemical binding]; other site 336982000670 homodimer interaction site [polypeptide binding]; other site 336982000671 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 336982000672 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 336982000673 active site 336982000674 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982000675 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982000676 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 336982000677 active site 336982000678 diiron metal binding site [ion binding]; other site 336982000679 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 336982000680 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 336982000681 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 336982000682 NAD(P) binding site [chemical binding]; other site 336982000683 catalytic residues [active] 336982000684 Lipase maturation factor; Region: LMF1; pfam06762 336982000685 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 336982000686 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 336982000687 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 336982000688 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 336982000689 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982000690 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982000691 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 336982000692 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 336982000693 MaoC like domain; Region: MaoC_dehydratas; pfam01575 336982000694 active site 2 [active] 336982000695 active site 1 [active] 336982000696 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 336982000697 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982000698 NAD(P) binding site [chemical binding]; other site 336982000699 active site 336982000700 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 336982000701 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 336982000702 dimer interface [polypeptide binding]; other site 336982000703 active site 336982000704 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 336982000705 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 336982000706 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 336982000707 FAD binding site [chemical binding]; other site 336982000708 substrate binding site [chemical binding]; other site 336982000709 catalytic residues [active] 336982000710 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 336982000711 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 336982000712 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 336982000713 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 336982000714 catalytic loop [active] 336982000715 iron binding site [ion binding]; other site 336982000716 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 336982000717 L-aspartate oxidase; Provisional; Region: PRK06175 336982000718 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 336982000719 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 336982000720 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 336982000721 putative dimer interface [polypeptide binding]; other site 336982000722 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 336982000723 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 336982000724 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 336982000725 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 336982000726 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 336982000727 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 336982000728 homotrimer interface [polypeptide binding]; other site 336982000729 Walker A motif; other site 336982000730 GTP binding site [chemical binding]; other site 336982000731 Walker B motif; other site 336982000732 cobyric acid synthase; Provisional; Region: PRK00784 336982000733 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 336982000734 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 336982000735 catalytic triad [active] 336982000736 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982000737 PPE family; Region: PPE; pfam00823 336982000738 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 336982000739 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 336982000740 putative active site [active] 336982000741 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 336982000742 putative active site [active] 336982000743 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 336982000744 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 336982000745 active site 336982000746 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 336982000747 DNA binding site [nucleotide binding] 336982000748 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 336982000749 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 336982000750 Coenzyme A binding pocket [chemical binding]; other site 336982000751 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 336982000752 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 336982000753 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 336982000754 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 336982000755 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 336982000756 intersubunit interface [polypeptide binding]; other site 336982000757 5-oxoprolinase; Region: PLN02666 336982000758 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 336982000759 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 336982000760 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 336982000761 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 336982000762 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 336982000763 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 336982000764 nucleotide binding site [chemical binding]; other site 336982000765 acyl-CoA synthetase; Validated; Region: PRK07788 336982000766 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 336982000767 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 336982000768 active site 336982000769 CoA binding site [chemical binding]; other site 336982000770 AMP binding site [chemical binding]; other site 336982000771 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 336982000772 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 336982000773 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 336982000774 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 336982000775 FAD binding site [chemical binding]; other site 336982000776 substrate binding site [chemical binding]; other site 336982000777 catalytic base [active] 336982000778 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 336982000779 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982000780 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982000781 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 336982000782 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 336982000783 Zn binding site [ion binding]; other site 336982000784 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 336982000785 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 336982000786 putative active site [active] 336982000787 PE family; Region: PE; pfam00934 336982000788 PE family; Region: PE; pfam00934 336982000789 PE family; Region: PE; pfam00934 336982000790 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982000791 PPE family; Region: PPE; pfam00823 336982000792 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982000793 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 336982000794 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 336982000795 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 336982000796 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 336982000797 Walker A motif; other site 336982000798 ATP binding site [chemical binding]; other site 336982000799 Walker B motif; other site 336982000800 arginine finger; other site 336982000801 Protein of unknown function (DUF690); Region: DUF690; pfam05108 336982000802 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 336982000803 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 336982000804 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 336982000805 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 336982000806 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 336982000807 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982000808 PPE family; Region: PPE; pfam00823 336982000809 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 336982000810 EspG family; Region: ESX-1_EspG; pfam14011 336982000811 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 336982000812 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 336982000813 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 336982000814 active site 336982000815 catalytic residues [active] 336982000816 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 336982000817 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 336982000818 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 336982000819 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 336982000820 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 336982000821 S-adenosylmethionine binding site [chemical binding]; other site 336982000822 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4424 336982000823 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 336982000824 Sulfatase; Region: Sulfatase; cl17466 336982000825 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 336982000826 putative active site [active] 336982000827 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982000828 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982000829 light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs; Region: LPOR_like_SDR_c_like; cd09810 336982000830 protochlorophyllide reductase; Region: PLN00015 336982000831 putative NAD(P) binding site [chemical binding]; other site 336982000832 active site 336982000833 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982000834 PPE family; Region: PPE; pfam00823 336982000835 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982000836 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982000837 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982000838 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982000839 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982000840 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982000841 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982000842 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982000843 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982000844 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982000845 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982000846 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982000847 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 336982000848 putative FMN binding site [chemical binding]; other site 336982000849 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 336982000850 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 336982000851 active site 336982000852 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 336982000853 SnoaL-like domain; Region: SnoaL_4; pfam13577 336982000854 SnoaL-like domain; Region: SnoaL_3; pfam13474 336982000855 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 336982000856 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 336982000857 nucleotide binding site [chemical binding]; other site 336982000858 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]; Region: HtpG; COG0326 336982000859 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 336982000860 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 336982000861 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 336982000862 active site 336982000863 catalytic residues [active] 336982000864 Muconolactone delta-isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CatC1; COG4829 336982000865 Muconolactone delta-isomerase; Region: MIase; cl01992 336982000866 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 336982000867 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 336982000868 putative active site [active] 336982000869 catalytic site [active] 336982000870 putative metal binding site [ion binding]; other site 336982000871 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 336982000872 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 336982000873 putative substrate binding pocket [chemical binding]; other site 336982000874 AC domain interface; other site 336982000875 catalytic triad [active] 336982000876 AB domain interface; other site 336982000877 interchain disulfide; other site 336982000878 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 336982000879 trimer interface [polypeptide binding]; other site 336982000880 active site 336982000881 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 336982000882 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 336982000883 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 336982000884 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 336982000885 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 336982000886 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 336982000887 dimerization interface [polypeptide binding]; other site 336982000888 putative DNA binding site [nucleotide binding]; other site 336982000889 putative Zn2+ binding site [ion binding]; other site 336982000890 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 336982000891 active site residue [active] 336982000892 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 336982000893 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 336982000894 Cytochrome P450; Region: p450; cl12078 336982000895 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 336982000896 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982000897 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 336982000898 Methyltransferase domain; Region: Methyltransf_23; pfam13489 336982000899 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 336982000900 S-adenosylmethionine binding site [chemical binding]; other site 336982000901 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982000902 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982000903 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 336982000904 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 336982000905 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 336982000906 SnoaL-like domain; Region: SnoaL_2; pfam12680 336982000907 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 336982000908 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 336982000909 substrate binding site; other site 336982000910 tetramer interface; other site 336982000911 PE family; Region: PE; pfam00934 336982000912 Domain of unknown function (DUF222); Region: DUF222; pfam02720 336982000913 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 336982000914 active site 336982000915 aminotransferase AlaT; Validated; Region: PRK09265 336982000916 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 336982000917 pyridoxal 5'-phosphate binding site [chemical binding]; other site 336982000918 homodimer interface [polypeptide binding]; other site 336982000919 catalytic residue [active] 336982000920 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 336982000921 4Fe-4S binding domain; Region: Fer4; pfam00037 336982000922 Cysteine-rich domain; Region: CCG; pfam02754 336982000923 Cysteine-rich domain; Region: CCG; pfam02754 336982000924 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 336982000925 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 336982000926 DNA binding residues [nucleotide binding] 336982000927 dimerization interface [polypeptide binding]; other site 336982000928 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 336982000929 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 336982000930 G1 box; other site 336982000931 GTP/Mg2+ binding site [chemical binding]; other site 336982000932 G2 box; other site 336982000933 Switch I region; other site 336982000934 G3 box; other site 336982000935 Switch II region; other site 336982000936 G4 box; other site 336982000937 G5 box; other site 336982000938 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 336982000939 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 336982000940 G1 box; other site 336982000941 GTP/Mg2+ binding site [chemical binding]; other site 336982000942 G2 box; other site 336982000943 Switch I region; other site 336982000944 G3 box; other site 336982000945 Switch II region; other site 336982000946 Uncharacterized MobA-related protein [General function prediction only]; Region: COG2068 336982000947 active site 336982000948 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 336982000949 TIGR04255 family protein; Region: sporadTIGR04255 336982000950 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 336982000951 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 336982000952 nucleotide binding site [chemical binding]; other site 336982000953 NEF interaction site [polypeptide binding]; other site 336982000954 SBD interface [polypeptide binding]; other site 336982000955 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 336982000956 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 336982000957 dimer interface [polypeptide binding]; other site 336982000958 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 336982000959 chaperone protein DnaJ; Provisional; Region: PRK14279 336982000960 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 336982000961 HSP70 interaction site [polypeptide binding]; other site 336982000962 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 336982000963 Zn binding sites [ion binding]; other site 336982000964 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 336982000965 dimer interface [polypeptide binding]; other site 336982000966 Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279 336982000967 DNA binding residues [nucleotide binding] 336982000968 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 336982000969 putative dimer interface [polypeptide binding]; other site 336982000970 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982000971 PPE family; Region: PPE; pfam00823 336982000972 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982000973 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982000974 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982000975 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982000976 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 336982000977 CoenzymeA binding site [chemical binding]; other site 336982000978 subunit interaction site [polypeptide binding]; other site 336982000979 PHB binding site; other site 336982000980 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 336982000981 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 336982000982 GDP-binding site [chemical binding]; other site 336982000983 ACT binding site; other site 336982000984 IMP binding site; other site 336982000985 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 336982000986 Peptidase family M50; Region: Peptidase_M50; pfam02163 336982000987 active site 336982000988 putative substrate binding region [chemical binding]; other site 336982000989 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 336982000990 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 336982000991 MgtE intracellular N domain; Region: MgtE_N; pfam03448 336982000992 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 336982000993 Divalent cation transporter; Region: MgtE; pfam01769 336982000994 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 336982000995 fructose-bisphosphate aldolase, class II, yeast/E. coli subtype; Region: FruBisAldo_II_A; TIGR01520 336982000996 active site 336982000997 intersubunit interface [polypeptide binding]; other site 336982000998 zinc binding site [ion binding]; other site 336982000999 Na+ binding site [ion binding]; other site 336982001000 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 336982001001 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 336982001002 Predicted glycosyl hydrolase [Carbohydrate transport and metabolism]; Region: COG4833 336982001003 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 336982001004 AAA domain; Region: AAA_33; pfam13671 336982001005 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 336982001006 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 336982001007 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 336982001008 putative hydrophobic ligand binding site [chemical binding]; other site 336982001009 MoxR-like ATPases [General function prediction only]; Region: COG0714 336982001010 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 336982001011 Ligand binding site; other site 336982001012 metal-binding site 336982001013 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 336982001014 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 336982001015 XdhC Rossmann domain; Region: XdhC_C; pfam13478 336982001016 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 336982001017 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 336982001018 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 336982001019 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 336982001020 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 336982001021 catalytic loop [active] 336982001022 iron binding site [ion binding]; other site 336982001023 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 336982001024 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 336982001025 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 336982001026 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 336982001027 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 336982001028 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 336982001029 XdhC Rossmann domain; Region: XdhC_C; pfam13478 336982001030 Transcriptional regulator [Transcription]; Region: LysR; COG0583 336982001031 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 336982001032 LysR substrate binding domain; Region: LysR_substrate; pfam03466 336982001033 dimerization interface [polypeptide binding]; other site 336982001034 Uncharacterized conserved protein [Function unknown]; Region: COG3360 336982001035 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 336982001036 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 336982001037 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 336982001038 active site 336982001039 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 336982001040 Clp amino terminal domain; Region: Clp_N; pfam02861 336982001041 Clp amino terminal domain; Region: Clp_N; pfam02861 336982001042 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 336982001043 Walker A motif; other site 336982001044 ATP binding site [chemical binding]; other site 336982001045 Walker B motif; other site 336982001046 arginine finger; other site 336982001047 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 336982001048 Walker A motif; other site 336982001049 ATP binding site [chemical binding]; other site 336982001050 Walker B motif; other site 336982001051 arginine finger; other site 336982001052 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 336982001053 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 336982001054 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 336982001055 heme-binding site [chemical binding]; other site 336982001056 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 336982001057 FAD binding pocket [chemical binding]; other site 336982001058 FAD binding motif [chemical binding]; other site 336982001059 phosphate binding motif [ion binding]; other site 336982001060 beta-alpha-beta structure motif; other site 336982001061 NAD binding pocket [chemical binding]; other site 336982001062 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 336982001063 cyclase homology domain; Region: CHD; cd07302 336982001064 nucleotidyl binding site; other site 336982001065 metal binding site [ion binding]; metal-binding site 336982001066 dimer interface [polypeptide binding]; other site 336982001067 Predicted ATPase [General function prediction only]; Region: COG3903 336982001068 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 336982001069 Walker A motif; other site 336982001070 ATP binding site [chemical binding]; other site 336982001071 Walker B motif; other site 336982001072 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 336982001073 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 336982001074 DNA binding residues [nucleotide binding] 336982001075 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982001076 PPE family; Region: PPE; pfam00823 336982001077 Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase) [Nucleotide transport and metabolism]; Region: PurT; COG0027 336982001078 ATP-grasp domain; Region: ATP-grasp_4; cl17255 336982001079 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 336982001080 active site residue [active] 336982001081 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 336982001082 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 336982001083 homodimer interface [polypeptide binding]; other site 336982001084 substrate-cofactor binding pocket; other site 336982001085 pyridoxal 5'-phosphate binding site [chemical binding]; other site 336982001086 catalytic residue [active] 336982001087 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 336982001088 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 336982001089 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 336982001090 Domain of unknown function (DUF222); Region: DUF222; pfam02720 336982001091 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 336982001092 active site 336982001093 PLD-like domain; Region: PLDc_2; pfam13091 336982001094 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 336982001095 Beta-lactamase; Region: Beta-lactamase; pfam00144 336982001096 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 336982001097 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 336982001098 FAD binding site [chemical binding]; other site 336982001099 substrate binding pocket [chemical binding]; other site 336982001100 catalytic base [active] 336982001101 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 336982001102 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 336982001103 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 336982001104 acyl-CoA synthetase; Validated; Region: PRK05850 336982001105 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 336982001106 acyl-activating enzyme (AAE) consensus motif; other site 336982001107 active site 336982001108 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 336982001109 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 336982001110 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 336982001111 active site 336982001112 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 336982001113 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 336982001114 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 336982001115 Thioesterase; Region: PKS_TE; smart00824 336982001116 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 336982001117 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 336982001118 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 336982001119 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 336982001120 phosphate acetyltransferase; Reviewed; Region: PRK05632 336982001121 DRTGG domain; Region: DRTGG; pfam07085 336982001122 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 336982001123 propionate/acetate kinase; Provisional; Region: PRK12379 336982001124 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 336982001125 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 336982001126 Catalytic domain of Protein Kinases; Region: PKc; cd00180 336982001127 active site 336982001128 ATP binding site [chemical binding]; other site 336982001129 substrate binding site [chemical binding]; other site 336982001130 activation loop (A-loop); other site 336982001131 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 336982001132 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 336982001133 substrate binding pocket [chemical binding]; other site 336982001134 membrane-bound complex binding site; other site 336982001135 hinge residues; other site 336982001136 NUDIX domain; Region: NUDIX; pfam00293 336982001137 nudix motif; other site 336982001138 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 336982001139 thiamine phosphate binding site [chemical binding]; other site 336982001140 active site 336982001141 pyrophosphate binding site [ion binding]; other site 336982001142 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 336982001143 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 336982001144 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 336982001145 thiS-thiF/thiG interaction site; other site 336982001146 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 336982001147 ThiS interaction site; other site 336982001148 putative active site [active] 336982001149 tetramer interface [polypeptide binding]; other site 336982001150 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 336982001151 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 336982001152 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 336982001153 PA/protease or protease-like domain interface [polypeptide binding]; other site 336982001154 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 336982001155 active site 336982001156 metal binding site [ion binding]; metal-binding site 336982001157 Predicted metalloprotease [General function prediction only]; Region: COG2321 336982001158 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 336982001159 Zn binding site [ion binding]; other site 336982001160 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 336982001161 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 336982001162 dimer interface [polypeptide binding]; other site 336982001163 substrate binding site [chemical binding]; other site 336982001164 ATP binding site [chemical binding]; other site 336982001165 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 336982001166 ThiC-associated domain; Region: ThiC-associated; pfam13667 336982001167 ThiC family; Region: ThiC; pfam01964 336982001168 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 336982001169 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 336982001170 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 336982001171 motif II; other site 336982001172 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 336982001173 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 336982001174 putative catalytic site [active] 336982001175 putative phosphate binding site [ion binding]; other site 336982001176 active site 336982001177 metal binding site A [ion binding]; metal-binding site 336982001178 DNA binding site [nucleotide binding] 336982001179 putative AP binding site [nucleotide binding]; other site 336982001180 putative metal binding site B [ion binding]; other site 336982001181 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 336982001182 active site 336982001183 catalytic residues [active] 336982001184 metal binding site [ion binding]; metal-binding site 336982001185 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 336982001186 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 336982001187 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 336982001188 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 336982001189 E-class dimer interface [polypeptide binding]; other site 336982001190 P-class dimer interface [polypeptide binding]; other site 336982001191 active site 336982001192 Cu2+ binding site [ion binding]; other site 336982001193 Zn2+ binding site [ion binding]; other site 336982001194 carboxylate-amine ligase; Provisional; Region: PRK13517 336982001195 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 336982001196 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 336982001197 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 336982001198 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 336982001199 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 336982001200 Walker A motif; other site 336982001201 ATP binding site [chemical binding]; other site 336982001202 Walker B motif; other site 336982001203 arginine finger; other site 336982001204 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 336982001205 Walker A motif; other site 336982001206 ATP binding site [chemical binding]; other site 336982001207 Walker B motif; other site 336982001208 arginine finger; other site 336982001209 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 336982001210 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 336982001211 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 336982001212 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 336982001213 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 336982001214 dimer interface [polypeptide binding]; other site 336982001215 putative functional site; other site 336982001216 putative MPT binding site; other site 336982001217 short chain dehydrogenase; Provisional; Region: PRK06197 336982001218 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 336982001219 putative NAD(P) binding site [chemical binding]; other site 336982001220 active site 336982001221 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 336982001222 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 336982001223 ring oligomerisation interface [polypeptide binding]; other site 336982001224 ATP/Mg binding site [chemical binding]; other site 336982001225 stacking interactions; other site 336982001226 hinge regions; other site 336982001227 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982001228 PPE family; Region: PPE; pfam00823 336982001229 Protein of unknown function (DUF664); Region: DUF664; pfam04978 336982001230 DinB superfamily; Region: DinB_2; pfam12867 336982001231 putative anti-sigmaE protein; Provisional; Region: PRK13920 336982001232 Anti-sigma-K factor rskA; Region: RskA; pfam10099 336982001233 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 336982001234 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 336982001235 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 336982001236 DNA binding residues [nucleotide binding] 336982001237 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 336982001238 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 336982001239 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 336982001240 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 336982001241 S-adenosylmethionine binding site [chemical binding]; other site 336982001242 Uncharacterized conserved protein [Function unknown]; Region: COG3496 336982001243 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 336982001244 Subunit A of Class III extradiol dioxygenases; Region: Extradiol_Dioxygenase_3A_like; cl06673 336982001245 dimer interface [polypeptide binding]; other site 336982001246 Transport protein; Region: actII; TIGR00833 336982001247 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 336982001248 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982001249 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982001250 PPE family; Region: PPE; pfam00823 336982001251 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 336982001252 enoyl-CoA hydratase; Provisional; Region: PRK12478 336982001253 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 336982001254 substrate binding site [chemical binding]; other site 336982001255 oxyanion hole (OAH) forming residues; other site 336982001256 trimer interface [polypeptide binding]; other site 336982001257 PemK-like protein; Region: PemK; pfam02452 336982001258 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 336982001259 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 336982001260 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 336982001261 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 336982001262 NAD(P) binding site [chemical binding]; other site 336982001263 catalytic residues [active] 336982001264 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3564 336982001265 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 336982001266 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 336982001267 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 336982001268 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 336982001269 Uncharacterized conserved protein [Function unknown]; Region: COG2128 336982001270 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 336982001271 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 336982001272 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 336982001273 non-specific DNA binding site [nucleotide binding]; other site 336982001274 salt bridge; other site 336982001275 sequence-specific DNA binding site [nucleotide binding]; other site 336982001276 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 336982001277 Domain of unknown function (DUF955); Region: DUF955; pfam06114 336982001278 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 336982001279 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 336982001280 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 336982001281 active site 336982001282 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 336982001283 active site 2 [active] 336982001284 isocitrate lyase; Provisional; Region: PRK15063 336982001285 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cd06556 336982001286 oligomerization interface [polypeptide binding]; other site 336982001287 active site 336982001288 metal binding site [ion binding]; metal-binding site 336982001289 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 336982001290 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 336982001291 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 336982001292 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 336982001293 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 336982001294 S-adenosylmethionine binding site [chemical binding]; other site 336982001295 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 336982001296 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 336982001297 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 336982001298 S-adenosylmethionine binding site [chemical binding]; other site 336982001299 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 336982001300 UbiA prenyltransferase family; Region: UbiA; pfam01040 336982001301 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982001302 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982001303 Predicted membrane protein [Function unknown]; Region: COG2733 336982001304 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 336982001305 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 336982001306 non-specific DNA binding site [nucleotide binding]; other site 336982001307 salt bridge; other site 336982001308 sequence-specific DNA binding site [nucleotide binding]; other site 336982001309 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 336982001310 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 336982001311 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 336982001312 intersubunit interface [polypeptide binding]; other site 336982001313 active site 336982001314 catalytic residue [active] 336982001315 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 336982001316 Predicted amidohydrolase [General function prediction only]; Region: COG0388 336982001317 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 336982001318 putative active site [active] 336982001319 catalytic triad [active] 336982001320 putative dimer interface [polypeptide binding]; other site 336982001321 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 336982001322 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 336982001323 FAD binding domain; Region: FAD_binding_4; pfam01565 336982001324 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 336982001325 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 336982001326 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 336982001327 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 336982001328 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 336982001329 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 336982001330 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982001331 NAD(P) binding site [chemical binding]; other site 336982001332 active site 336982001333 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 336982001334 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 336982001335 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 336982001336 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 336982001337 putative ADP-binding pocket [chemical binding]; other site 336982001338 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 336982001339 L-lysine exporter; Region: 2a75; TIGR00948 336982001340 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 336982001341 catalytic core [active] 336982001342 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 336982001343 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 336982001344 dimer interface [polypeptide binding]; other site 336982001345 phosphorylation site [posttranslational modification] 336982001346 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 336982001347 ATP binding site [chemical binding]; other site 336982001348 Mg2+ binding site [ion binding]; other site 336982001349 G-X-G motif; other site 336982001350 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 336982001351 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 336982001352 active site 336982001353 phosphorylation site [posttranslational modification] 336982001354 intermolecular recognition site; other site 336982001355 dimerization interface [polypeptide binding]; other site 336982001356 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 336982001357 DNA binding site [nucleotide binding] 336982001358 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 336982001359 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 336982001360 Transcriptional regulators [Transcription]; Region: FadR; COG2186 336982001361 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 336982001362 DNA-binding site [nucleotide binding]; DNA binding site 336982001363 FCD domain; Region: FCD; pfam07729 336982001364 exopolyphosphatase; Region: exo_poly_only; TIGR03706 336982001365 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 336982001366 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 336982001367 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 336982001368 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 336982001369 Diacylglycerol kinase catalytic domain (presumed); Region: DAGKc; smart00046 336982001370 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 336982001371 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 336982001372 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 336982001373 DNA binding domain, excisionase family; Region: excise; TIGR01764 336982001374 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 336982001375 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 336982001376 putative NAD(P) binding site [chemical binding]; other site 336982001377 active site 336982001378 putative substrate binding site [chemical binding]; other site 336982001379 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 336982001380 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 336982001381 putative acyl-acceptor binding pocket; other site 336982001382 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 336982001383 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 336982001384 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 336982001385 S-adenosylmethionine binding site [chemical binding]; other site 336982001386 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 336982001387 active site 336982001388 catalytic site [active] 336982001389 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 336982001390 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 336982001391 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 336982001392 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 336982001393 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 336982001394 glutamyl-tRNA reductase; Region: hemA; TIGR01035 336982001395 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 336982001396 tRNA; other site 336982001397 putative tRNA binding site [nucleotide binding]; other site 336982001398 putative NADP binding site [chemical binding]; other site 336982001399 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 336982001400 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 336982001401 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 336982001402 domain interfaces; other site 336982001403 active site 336982001404 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 336982001405 active site 336982001406 homodimer interface [polypeptide binding]; other site 336982001407 SAM binding site [chemical binding]; other site 336982001408 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 336982001409 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 336982001410 active site 336982001411 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 336982001412 dimer interface [polypeptide binding]; other site 336982001413 active site 336982001414 Schiff base residues; other site 336982001415 Domain of unknown function (DUF222); Region: DUF222; pfam02720 336982001416 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 336982001417 active site 336982001418 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 336982001419 anti sigma factor interaction site; other site 336982001420 regulatory phosphorylation site [posttranslational modification]; other site 336982001421 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 336982001422 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 336982001423 active site 336982001424 catalytic triad [active] 336982001425 oxyanion hole [active] 336982001426 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 336982001427 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 336982001428 Methyltransferase domain; Region: Methyltransf_31; pfam13847 336982001429 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 336982001430 Domain of unknown function (DUF385); Region: DUF385; pfam04075 336982001431 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 336982001432 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 336982001433 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 336982001434 catalytic residue [active] 336982001435 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 336982001436 catalytic core [active] 336982001437 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 336982001438 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 336982001439 catalytic residues [active] 336982001440 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 336982001441 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 336982001442 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 336982001443 ResB-like family; Region: ResB; pfam05140 336982001444 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 336982001445 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 336982001446 AAA domain; Region: AAA_31; pfam13614 336982001447 P-loop; other site 336982001448 Magnesium ion binding site [ion binding]; other site 336982001449 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 336982001450 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 336982001451 3-oxoacyl-(acyl-carrier-protein) synthase III; Region: fabH; TIGR00747 336982001452 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 336982001453 dimer interface [polypeptide binding]; other site 336982001454 active site 336982001455 CoA binding pocket [chemical binding]; other site 336982001456 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 336982001457 UbiA prenyltransferase family; Region: UbiA; pfam01040 336982001458 5'-methylthioadenosine phosphorylase; Validated; Region: PRK07823 336982001459 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 336982001460 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982001461 NAD(P) binding site [chemical binding]; other site 336982001462 active site 336982001463 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 336982001464 Ligand binding site; other site 336982001465 Putative Catalytic site; other site 336982001466 DXD motif; other site 336982001467 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3222 336982001468 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 336982001469 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 336982001470 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 336982001471 acyl-activating enzyme (AAE) consensus motif; other site 336982001472 acyl-activating enzyme (AAE) consensus motif; other site 336982001473 AMP binding site [chemical binding]; other site 336982001474 active site 336982001475 CoA binding site [chemical binding]; other site 336982001476 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 336982001477 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 336982001478 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 336982001479 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 336982001480 active site 336982001481 short chain dehydrogenase; Provisional; Region: PRK05866 336982001482 classical (c) SDRs; Region: SDR_c; cd05233 336982001483 NAD(P) binding site [chemical binding]; other site 336982001484 active site 336982001485 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 336982001486 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 336982001487 substrate binding site [chemical binding]; other site 336982001488 oxyanion hole (OAH) forming residues; other site 336982001489 trimer interface [polypeptide binding]; other site 336982001490 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 336982001491 putative active site [active] 336982001492 homotetrameric interface [polypeptide binding]; other site 336982001493 metal binding site [ion binding]; metal-binding site 336982001494 acyl-CoA synthetase; Validated; Region: PRK06188 336982001495 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 336982001496 putative active site [active] 336982001497 putative CoA binding site [chemical binding]; other site 336982001498 putative AMP binding site [chemical binding]; other site 336982001499 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 336982001500 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 336982001501 active site 336982001502 O-succinylbenzoate synthase; Provisional; Region: PRK02901 336982001503 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 336982001504 active site 336982001505 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 336982001506 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 336982001507 TAP-like protein; Region: Abhydrolase_4; pfam08386 336982001508 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 336982001509 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 336982001510 dimer interface [polypeptide binding]; other site 336982001511 tetramer interface [polypeptide binding]; other site 336982001512 PYR/PP interface [polypeptide binding]; other site 336982001513 TPP binding site [chemical binding]; other site 336982001514 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 336982001515 TPP-binding site; other site 336982001516 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 336982001517 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 336982001518 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 336982001519 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 336982001520 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 336982001521 S-adenosylmethionine binding site [chemical binding]; other site 336982001522 Protein of unknown function (DUF732); Region: DUF732; pfam05305 336982001523 Methyltransferase domain; Region: Methyltransf_23; pfam13489 336982001524 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 336982001525 S-adenosylmethionine binding site [chemical binding]; other site 336982001526 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 336982001527 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 336982001528 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 336982001529 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 336982001530 substrate binding pocket [chemical binding]; other site 336982001531 chain length determination region; other site 336982001532 substrate-Mg2+ binding site; other site 336982001533 catalytic residues [active] 336982001534 aspartate-rich region 1; other site 336982001535 active site lid residues [active] 336982001536 aspartate-rich region 2; other site 336982001537 heat shock protein HtpX; Provisional; Region: PRK03072 336982001538 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439 336982001539 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 336982001540 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 336982001541 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 336982001542 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 336982001543 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 336982001544 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 336982001545 O-methyltransferase; Region: Methyltransf_2; pfam00891 336982001546 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 336982001547 Cytochrome P450; Region: p450; cl12078 336982001548 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 336982001549 ATP cone domain; Region: ATP-cone; pfam03477 336982001550 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 336982001551 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 336982001552 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 336982001553 active site 336982001554 dimer interface [polypeptide binding]; other site 336982001555 effector binding site; other site 336982001556 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 336982001557 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 336982001558 active site 336982001559 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 336982001560 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 336982001561 nicotinate phosphoribosyltransferase; Provisional; Region: PRK12484 336982001562 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 336982001563 active site 336982001564 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 336982001565 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 336982001566 putative active site [active] 336982001567 putative metal binding site [ion binding]; other site 336982001568 hypothetical protein; Provisional; Region: PRK07588 336982001569 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 336982001570 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 336982001571 dimerization interface [polypeptide binding]; other site 336982001572 putative DNA binding site [nucleotide binding]; other site 336982001573 putative Zn2+ binding site [ion binding]; other site 336982001574 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 336982001575 putative hydrophobic ligand binding site [chemical binding]; other site 336982001576 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 336982001577 TIGR03086 family protein; Region: TIGR03086 336982001578 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 336982001579 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 336982001580 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 336982001581 PE family; Region: PE; pfam00934 336982001582 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451 336982001583 Uncharacterized conserved protein [Function unknown]; Region: COG1656 336982001584 Protein of unknown function DUF82; Region: DUF82; pfam01927 336982001585 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 336982001586 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 336982001587 putative active site [active] 336982001588 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 336982001589 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 336982001590 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 336982001591 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 336982001592 Transcriptional regulators [Transcription]; Region: FadR; COG2186 336982001593 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 336982001594 DNA-binding site [nucleotide binding]; DNA binding site 336982001595 FCD domain; Region: FCD; pfam07729 336982001596 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 336982001597 Permease; Region: Permease; pfam02405 336982001598 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 336982001599 Permease; Region: Permease; pfam02405 336982001600 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 336982001601 mce related protein; Region: MCE; pfam02470 336982001602 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 336982001603 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 336982001604 mce related protein; Region: MCE; pfam02470 336982001605 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 336982001606 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 336982001607 mce related protein; Region: MCE; pfam02470 336982001608 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 336982001609 mce related protein; Region: MCE; pfam02470 336982001610 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 336982001611 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 336982001612 mce related protein; Region: MCE; pfam02470 336982001613 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 336982001614 mce related protein; Region: MCE; pfam02470 336982001615 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 336982001616 oligomeric interface; other site 336982001617 putative active site [active] 336982001618 homodimer interface [polypeptide binding]; other site 336982001619 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 336982001620 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 336982001621 AAA domain; Region: AAA_14; pfam13173 336982001622 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 336982001623 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 336982001624 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 336982001625 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 336982001626 ATP binding site [chemical binding]; other site 336982001627 Mg2+ binding site [ion binding]; other site 336982001628 G-X-G motif; other site 336982001629 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 336982001630 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 336982001631 active site 336982001632 phosphorylation site [posttranslational modification] 336982001633 intermolecular recognition site; other site 336982001634 dimerization interface [polypeptide binding]; other site 336982001635 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 336982001636 DNA binding site [nucleotide binding] 336982001637 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 336982001638 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 336982001639 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 336982001640 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 336982001641 catalytic residues [active] 336982001642 catalytic nucleophile [active] 336982001643 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 336982001644 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 336982001645 Probable transposase; Region: OrfB_IS605; pfam01385 336982001646 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 336982001647 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 336982001648 putative active site [active] 336982001649 SEC-C motif; Region: SEC-C; pfam02810 336982001650 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB-like; cd09875 336982001651 putative active site [active] 336982001652 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 336982001653 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 336982001654 nucleotide binding site/active site [active] 336982001655 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 336982001656 galactokinase; Provisional; Region: PRK00555 336982001657 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 336982001658 Protein of unknown function (DUF732); Region: DUF732; pfam05305 336982001659 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 336982001660 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 336982001661 putative active site [active] 336982001662 Uncharacterized conserved protein [Function unknown]; Region: COG0398 336982001663 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 336982001664 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 336982001665 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 336982001666 oligomeric interface; other site 336982001667 putative active site [active] 336982001668 homodimer interface [polypeptide binding]; other site 336982001669 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 336982001670 FIST N domain; Region: FIST; pfam08495 336982001671 FIST C domain; Region: FIST_C; pfam10442 336982001672 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 336982001673 AAA domain; Region: AAA_30; pfam13604 336982001674 Family description; Region: UvrD_C_2; pfam13538 336982001675 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 336982001676 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 336982001677 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 336982001678 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 336982001679 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 336982001680 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 336982001681 substrate binding site [chemical binding]; other site 336982001682 oxyanion hole (OAH) forming residues; other site 336982001683 trimer interface [polypeptide binding]; other site 336982001684 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 336982001685 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 336982001686 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 336982001687 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 336982001688 active site 336982001689 catalytic site [active] 336982001690 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 336982001691 active site 336982001692 catalytic site [active] 336982001693 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 336982001694 active site 336982001695 catalytic site [active] 336982001696 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 336982001697 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 336982001698 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 336982001699 putative homodimer interface [polypeptide binding]; other site 336982001700 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 336982001701 heterodimer interface [polypeptide binding]; other site 336982001702 homodimer interface [polypeptide binding]; other site 336982001703 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 336982001704 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 336982001705 23S rRNA interface [nucleotide binding]; other site 336982001706 L7/L12 interface [polypeptide binding]; other site 336982001707 putative thiostrepton binding site; other site 336982001708 L25 interface [polypeptide binding]; other site 336982001709 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 336982001710 mRNA/rRNA interface [nucleotide binding]; other site 336982001711 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 336982001712 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 336982001713 S-adenosylmethionine binding site [chemical binding]; other site 336982001714 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 336982001715 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 336982001716 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 336982001717 S-adenosylmethionine binding site [chemical binding]; other site 336982001718 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 336982001719 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 336982001720 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 336982001721 S-adenosylmethionine binding site [chemical binding]; other site 336982001722 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 336982001723 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 336982001724 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 336982001725 S-adenosylmethionine binding site [chemical binding]; other site 336982001726 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 336982001727 TAP-like protein; Region: Abhydrolase_4; pfam08386 336982001728 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 336982001729 ABC1 family; Region: ABC1; cl17513 336982001730 N-terminal catalytic domain of class II alpha-mannosidases and similar proteins; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_like; cd10786 336982001731 active site 336982001732 catalytic site [active] 336982001733 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 336982001734 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 336982001735 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 336982001736 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 336982001737 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 336982001738 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 336982001739 23S rRNA interface [nucleotide binding]; other site 336982001740 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 336982001741 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 336982001742 core dimer interface [polypeptide binding]; other site 336982001743 peripheral dimer interface [polypeptide binding]; other site 336982001744 L10 interface [polypeptide binding]; other site 336982001745 L11 interface [polypeptide binding]; other site 336982001746 putative EF-Tu interaction site [polypeptide binding]; other site 336982001747 putative EF-G interaction site [polypeptide binding]; other site 336982001748 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982001749 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982001750 WHG domain; Region: WHG; pfam13305 336982001751 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 336982001752 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 336982001753 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 336982001754 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 336982001755 Walker A/P-loop; other site 336982001756 ATP binding site [chemical binding]; other site 336982001757 Q-loop/lid; other site 336982001758 ABC transporter signature motif; other site 336982001759 Walker B; other site 336982001760 D-loop; other site 336982001761 H-loop/switch region; other site 336982001762 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 336982001763 putative active site [active] 336982001764 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 336982001765 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 336982001766 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 336982001767 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG1848 336982001768 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 336982001769 Sulfatase; Region: Sulfatase; pfam00884 336982001770 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 336982001771 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 336982001772 putative active site [active] 336982001773 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 336982001774 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 336982001775 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 336982001776 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 336982001777 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 336982001778 RPB10 interaction site [polypeptide binding]; other site 336982001779 RPB1 interaction site [polypeptide binding]; other site 336982001780 RPB11 interaction site [polypeptide binding]; other site 336982001781 RPB3 interaction site [polypeptide binding]; other site 336982001782 RPB12 interaction site [polypeptide binding]; other site 336982001783 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 336982001784 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 336982001785 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 336982001786 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 336982001787 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 336982001788 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 336982001789 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 336982001790 G-loop; other site 336982001791 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 336982001792 DNA binding site [nucleotide binding] 336982001793 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 336982001794 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; pfam04734 336982001795 endonuclease IV; Provisional; Region: PRK01060 336982001796 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 336982001797 AP (apurinic/apyrimidinic) site pocket; other site 336982001798 DNA interaction; other site 336982001799 Metal-binding active site; metal-binding site 336982001800 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 336982001801 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 336982001802 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 336982001803 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 336982001804 active site 336982001805 enoyl-CoA hydratase; Provisional; Region: PRK12478 336982001806 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 336982001807 substrate binding site [chemical binding]; other site 336982001808 oxyanion hole (OAH) forming residues; other site 336982001809 trimer interface [polypeptide binding]; other site 336982001810 Phenylacetic acid-responsive transcriptional repressor [Transcription]; Region: PaaX; COG3327 336982001811 PaaX-like protein; Region: PaaX; pfam07848 336982001812 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 336982001813 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 336982001814 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 336982001815 substrate binding site [chemical binding]; other site 336982001816 oxyanion hole (OAH) forming residues; other site 336982001817 trimer interface [polypeptide binding]; other site 336982001818 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 336982001819 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 336982001820 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 336982001821 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 336982001822 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982001823 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982001824 WHG domain; Region: WHG; pfam13305 336982001825 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 336982001826 S17 interaction site [polypeptide binding]; other site 336982001827 S8 interaction site; other site 336982001828 16S rRNA interaction site [nucleotide binding]; other site 336982001829 streptomycin interaction site [chemical binding]; other site 336982001830 23S rRNA interaction site [nucleotide binding]; other site 336982001831 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 336982001832 30S ribosomal protein S7; Validated; Region: PRK05302 336982001833 elongation factor G; Reviewed; Region: PRK00007 336982001834 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 336982001835 G1 box; other site 336982001836 putative GEF interaction site [polypeptide binding]; other site 336982001837 GTP/Mg2+ binding site [chemical binding]; other site 336982001838 Switch I region; other site 336982001839 G2 box; other site 336982001840 G3 box; other site 336982001841 Switch II region; other site 336982001842 G4 box; other site 336982001843 G5 box; other site 336982001844 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 336982001845 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 336982001846 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 336982001847 elongation factor Tu; Reviewed; Region: PRK00049 336982001848 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 336982001849 G1 box; other site 336982001850 GEF interaction site [polypeptide binding]; other site 336982001851 GTP/Mg2+ binding site [chemical binding]; other site 336982001852 Switch I region; other site 336982001853 G2 box; other site 336982001854 G3 box; other site 336982001855 Switch II region; other site 336982001856 G4 box; other site 336982001857 G5 box; other site 336982001858 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 336982001859 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 336982001860 Antibiotic Binding Site [chemical binding]; other site 336982001861 Short C-terminal domain; Region: SHOCT; pfam09851 336982001862 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 336982001863 classical (c) SDRs; Region: SDR_c; cd05233 336982001864 NAD(P) binding site [chemical binding]; other site 336982001865 active site 336982001866 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 336982001867 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 336982001868 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4427 336982001869 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 336982001870 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982001871 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 336982001872 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 336982001873 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 336982001874 FeS/SAM binding site; other site 336982001875 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 336982001876 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 336982001877 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 336982001878 phosphate binding site [ion binding]; other site 336982001879 mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964 336982001880 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 336982001881 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 336982001882 Probable Catalytic site; other site 336982001883 metal-binding site 336982001884 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 336982001885 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 336982001886 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 336982001887 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 336982001888 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 336982001889 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 336982001890 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 336982001891 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 336982001892 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 336982001893 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 336982001894 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 336982001895 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 336982001896 putative translocon binding site; other site 336982001897 protein-rRNA interface [nucleotide binding]; other site 336982001898 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 336982001899 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 336982001900 G-X-X-G motif; other site 336982001901 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 336982001902 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 336982001903 23S rRNA interface [nucleotide binding]; other site 336982001904 5S rRNA interface [nucleotide binding]; other site 336982001905 putative antibiotic binding site [chemical binding]; other site 336982001906 L25 interface [polypeptide binding]; other site 336982001907 L27 interface [polypeptide binding]; other site 336982001908 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 336982001909 putative translocon interaction site; other site 336982001910 23S rRNA interface [nucleotide binding]; other site 336982001911 signal recognition particle (SRP54) interaction site; other site 336982001912 L23 interface [polypeptide binding]; other site 336982001913 trigger factor interaction site; other site 336982001914 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 336982001915 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 336982001916 Sulfatase; Region: Sulfatase; pfam00884 336982001917 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353 336982001918 Uncharacterized conserved protein [Function unknown]; Region: COG1262 336982001919 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 336982001920 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 336982001921 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 336982001922 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 336982001923 RNA binding site [nucleotide binding]; other site 336982001924 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 336982001925 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 336982001926 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 336982001927 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 336982001928 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 336982001929 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 336982001930 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 336982001931 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 336982001932 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 336982001933 5S rRNA interface [nucleotide binding]; other site 336982001934 23S rRNA interface [nucleotide binding]; other site 336982001935 L5 interface [polypeptide binding]; other site 336982001936 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 336982001937 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 336982001938 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 336982001939 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 336982001940 23S rRNA binding site [nucleotide binding]; other site 336982001941 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 336982001942 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 336982001943 tandem repeat interface [polypeptide binding]; other site 336982001944 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 336982001945 oligomer interface [polypeptide binding]; other site 336982001946 active site residues [active] 336982001947 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 336982001948 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 336982001949 tandem repeat interface [polypeptide binding]; other site 336982001950 oligomer interface [polypeptide binding]; other site 336982001951 active site residues [active] 336982001952 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 336982001953 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 336982001954 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 336982001955 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 336982001956 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 336982001957 intersubunit interface [polypeptide binding]; other site 336982001958 active site 336982001959 Zn2+ binding site [ion binding]; other site 336982001960 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 336982001961 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 336982001962 NAD binding site [chemical binding]; other site 336982001963 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 336982001964 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 336982001965 nucleotide binding site [chemical binding]; other site 336982001966 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 336982001967 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 336982001968 Coenzyme A binding pocket [chemical binding]; other site 336982001969 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 336982001970 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 336982001971 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 336982001972 SecY translocase; Region: SecY; pfam00344 336982001973 adenylate kinase; Reviewed; Region: adk; PRK00279 336982001974 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 336982001975 AMP-binding site [chemical binding]; other site 336982001976 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 336982001977 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 336982001978 active site 336982001979 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 336982001980 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 336982001981 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 336982001982 DNA binding residues [nucleotide binding] 336982001983 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 336982001984 Putative zinc-finger; Region: zf-HC2; pfam13490 336982001985 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 336982001986 MarR family; Region: MarR; pfam01047 336982001987 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 336982001988 TIGR03086 family protein; Region: TIGR03086 336982001989 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 336982001990 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 336982001991 Transposase; Region: DDE_Tnp_ISL3; pfam01610 336982001992 Helix-turn-helix domain; Region: HTH_17; pfam12728 336982001993 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 336982001994 PE family; Region: PE; pfam00934 336982001995 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 336982001996 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 336982001997 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 336982001998 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 336982001999 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 336982002000 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 336982002001 active site 336982002002 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 336982002003 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 336982002004 tetrameric interface [polypeptide binding]; other site 336982002005 NAD binding site [chemical binding]; other site 336982002006 catalytic residues [active] 336982002007 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 336982002008 catalytic core [active] 336982002009 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982002010 PPE family; Region: PPE; pfam00823 336982002011 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982002012 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982002013 Helix-turn-helix domain; Region: HTH_28; pfam13518 336982002014 Winged helix-turn helix; Region: HTH_29; pfam13551 336982002015 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 336982002016 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 336982002017 active site 336982002018 phosphorylation site [posttranslational modification] 336982002019 intermolecular recognition site; other site 336982002020 dimerization interface [polypeptide binding]; other site 336982002021 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 336982002022 DNA binding site [nucleotide binding] 336982002023 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 336982002024 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 336982002025 dimerization interface [polypeptide binding]; other site 336982002026 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 336982002027 dimer interface [polypeptide binding]; other site 336982002028 phosphorylation site [posttranslational modification] 336982002029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 336982002030 ATP binding site [chemical binding]; other site 336982002031 Mg2+ binding site [ion binding]; other site 336982002032 G-X-G motif; other site 336982002033 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 336982002034 nucleotide binding site/active site [active] 336982002035 HIT family signature motif; other site 336982002036 catalytic residue [active] 336982002037 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 336982002038 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 336982002039 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 336982002040 NAD binding site [chemical binding]; other site 336982002041 catalytic Zn binding site [ion binding]; other site 336982002042 substrate binding site [chemical binding]; other site 336982002043 structural Zn binding site [ion binding]; other site 336982002044 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 336982002045 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 336982002046 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 336982002047 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 336982002048 Cytochrome P450; Region: p450; cl12078 336982002049 short chain dehydrogenase; Provisional; Region: PRK07775 336982002050 classical (c) SDRs; Region: SDR_c; cd05233 336982002051 NAD(P) binding site [chemical binding]; other site 336982002052 active site 336982002053 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 336982002054 Cytochrome P450; Region: p450; cl12078 336982002055 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982002056 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 336982002057 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 336982002058 NAD binding site [chemical binding]; other site 336982002059 catalytic residues [active] 336982002060 short chain dehydrogenase; Provisional; Region: PRK07774 336982002061 classical (c) SDRs; Region: SDR_c; cd05233 336982002062 NAD(P) binding site [chemical binding]; other site 336982002063 active site 336982002064 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 336982002065 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 336982002066 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 336982002067 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 336982002068 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 336982002069 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 336982002070 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 336982002071 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 336982002072 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 336982002073 Predicted esterase [General function prediction only]; Region: COG0627 336982002074 S-formylglutathione hydrolase; Region: PLN02442 336982002075 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 336982002076 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 336982002077 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 336982002078 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 336982002079 tetramer interface [polypeptide binding]; other site 336982002080 active site 336982002081 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 336982002082 Cytochrome P450; Region: p450; cl12078 336982002083 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 336982002084 ATP binding site [chemical binding]; other site 336982002085 active site 336982002086 substrate binding site [chemical binding]; other site 336982002087 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 336982002088 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 336982002089 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 336982002090 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 336982002091 putative substrate translocation pore; other site 336982002092 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 336982002093 Predicted deacetylase [General function prediction only]; Region: COG3233 336982002094 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 336982002095 putative active site [active] 336982002096 putative Zn binding site [ion binding]; other site 336982002097 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 336982002098 FAD binding domain; Region: FAD_binding_2; pfam00890 336982002099 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 336982002100 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 336982002101 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 336982002102 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 336982002103 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 336982002104 putative active site [active] 336982002105 catalytic triad [active] 336982002106 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 336982002107 Transglutaminase/protease-like homologues; Region: TGc; smart00460 336982002108 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 336982002109 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 336982002110 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 336982002111 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 336982002112 DNA-binding site [nucleotide binding]; DNA binding site 336982002113 UTRA domain; Region: UTRA; pfam07702 336982002114 Uncharacterized conserved protein [Function unknown]; Region: COG1359 336982002115 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 336982002116 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 336982002117 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 336982002118 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 336982002119 Transposase; Region: DEDD_Tnp_IS110; pfam01548 336982002120 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 336982002121 Transposase; Region: DEDD_Tnp_IS110; pfam01548 336982002122 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 336982002123 Uncharacterized protein, linocin/CFP29 homolog [Function unknown]; Region: COG1659 336982002124 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 336982002125 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 336982002126 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 336982002127 active site 336982002128 metal binding site [ion binding]; metal-binding site 336982002129 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 336982002130 active site 336982002131 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 336982002132 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 336982002133 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 336982002134 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 336982002135 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 336982002136 dimerization interface [polypeptide binding]; other site 336982002137 ATP binding site [chemical binding]; other site 336982002138 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 336982002139 dimerization interface [polypeptide binding]; other site 336982002140 ATP binding site [chemical binding]; other site 336982002141 CAAX protease self-immunity; Region: Abi; pfam02517 336982002142 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 336982002143 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 336982002144 active site 336982002145 metal binding site [ion binding]; metal-binding site 336982002146 hexamer interface [polypeptide binding]; other site 336982002147 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 336982002148 amidophosphoribosyltransferase; Provisional; Region: PRK07847 336982002149 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 336982002150 active site 336982002151 tetramer interface [polypeptide binding]; other site 336982002152 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 336982002153 active site 336982002154 phosphoribosylaminoimidazole synthetase; Region: purM; TIGR00878 336982002155 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 336982002156 dimerization interface [polypeptide binding]; other site 336982002157 putative ATP binding site [chemical binding]; other site 336982002158 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 336982002159 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 336982002160 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 336982002161 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 336982002162 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 336982002163 pyridoxal 5'-phosphate binding site [chemical binding]; other site 336982002164 catalytic residue [active] 336982002165 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 336982002166 heme-binding site [chemical binding]; other site 336982002167 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 336982002168 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 336982002169 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 336982002170 active site residue [active] 336982002171 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 336982002172 active site residue [active] 336982002173 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 336982002174 catalytic residues [active] 336982002175 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 336982002176 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 336982002177 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 336982002178 DNA binding site [nucleotide binding] 336982002179 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 336982002180 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 336982002181 Coenzyme A binding pocket [chemical binding]; other site 336982002182 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 336982002183 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 336982002184 Walker A/P-loop; other site 336982002185 ATP binding site [chemical binding]; other site 336982002186 Q-loop/lid; other site 336982002187 ABC transporter signature motif; other site 336982002188 Walker B; other site 336982002189 D-loop; other site 336982002190 H-loop/switch region; other site 336982002191 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 336982002192 PhoU domain; Region: PhoU; pfam01895 336982002193 PhoU domain; Region: PhoU; pfam01895 336982002194 cell envelope-related function transcriptional attenuator common domain; Region: lytR_cpsA_psr; TIGR00350 336982002195 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 336982002196 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 336982002197 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 336982002198 FMN binding site [chemical binding]; other site 336982002199 active site 336982002200 catalytic residues [active] 336982002201 substrate binding site [chemical binding]; other site 336982002202 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 336982002203 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 336982002204 homodimer interface [polypeptide binding]; other site 336982002205 putative substrate binding pocket [chemical binding]; other site 336982002206 diiron center [ion binding]; other site 336982002207 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982002208 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 336982002209 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 336982002210 dimerization interface [polypeptide binding]; other site 336982002211 putative DNA binding site [nucleotide binding]; other site 336982002212 putative Zn2+ binding site [ion binding]; other site 336982002213 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 336982002214 dimer interface [polypeptide binding]; other site 336982002215 catalytic motif [active] 336982002216 nucleoside/Zn binding site; other site 336982002217 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 336982002218 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 336982002219 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 336982002220 TIGR04255 family protein; Region: sporadTIGR04255 336982002221 PE family; Region: PE; pfam00934 336982002222 PE family; Region: PE; pfam00934 336982002223 PknH-like extracellular domain; Region: PknH_C; pfam14032 336982002224 putative transposase OrfB; Reviewed; Region: PHA02517 336982002225 HTH-like domain; Region: HTH_21; pfam13276 336982002226 Integrase core domain; Region: rve; pfam00665 336982002227 Integrase core domain; Region: rve_3; pfam13683 336982002228 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 336982002229 Transposase; Region: HTH_Tnp_1; cl17663 336982002230 Predicted nucleotidyltransferase [General function prediction only]; Region: COG4849 336982002231 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4861 336982002232 Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952 336982002233 D-ala-D-ala dipeptidase; Region: Peptidase_M15; pfam01427 336982002234 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 336982002235 S-adenosylmethionine binding site [chemical binding]; other site 336982002236 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 336982002237 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 336982002238 putative substrate translocation pore; other site 336982002239 Major Facilitator Superfamily; Region: MFS_1; pfam07690 336982002240 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 336982002241 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 336982002242 tetramer interface [polypeptide binding]; other site 336982002243 TPP-binding site [chemical binding]; other site 336982002244 heterodimer interface [polypeptide binding]; other site 336982002245 phosphorylation loop region [posttranslational modification] 336982002246 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 336982002247 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 336982002248 active site 336982002249 phosphorylation site [posttranslational modification] 336982002250 intermolecular recognition site; other site 336982002251 dimerization interface [polypeptide binding]; other site 336982002252 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 336982002253 DNA binding residues [nucleotide binding] 336982002254 dimerization interface [polypeptide binding]; other site 336982002255 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 336982002256 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 336982002257 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 336982002258 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 336982002259 Multicopper oxidase; Region: Cu-oxidase; pfam00394 336982002260 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 336982002261 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 336982002262 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 336982002263 dimer interface [polypeptide binding]; other site 336982002264 pyridoxal 5'-phosphate binding site [chemical binding]; other site 336982002265 catalytic residue [active] 336982002266 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 336982002267 multidrug resistance protein MdtH; Provisional; Region: PRK11646 336982002268 putative substrate translocation pore; other site 336982002269 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 336982002270 short chain dehydrogenase; Provisional; Region: PRK05876 336982002271 classical (c) SDRs; Region: SDR_c; cd05233 336982002272 NAD(P) binding site [chemical binding]; other site 336982002273 active site 336982002274 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 336982002275 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 336982002276 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 336982002277 dimer interface [polypeptide binding]; other site 336982002278 PYR/PP interface [polypeptide binding]; other site 336982002279 TPP binding site [chemical binding]; other site 336982002280 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 336982002281 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 336982002282 TPP-binding site [chemical binding]; other site 336982002283 dimer interface [polypeptide binding]; other site 336982002284 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 336982002285 putative hydrophobic ligand binding site [chemical binding]; other site 336982002286 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 336982002287 CoA-transferase family III; Region: CoA_transf_3; pfam02515 336982002288 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 336982002289 putative hydrophobic ligand binding site [chemical binding]; other site 336982002290 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 336982002291 putative hydrophobic ligand binding site [chemical binding]; other site 336982002292 aminotransferase; Validated; Region: PRK07777 336982002293 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 336982002294 pyridoxal 5'-phosphate binding site [chemical binding]; other site 336982002295 homodimer interface [polypeptide binding]; other site 336982002296 catalytic residue [active] 336982002297 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 336982002298 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 336982002299 dimer interface [polypeptide binding]; other site 336982002300 active site 336982002301 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 336982002302 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 336982002303 substrate binding site [chemical binding]; other site 336982002304 oxyanion hole (OAH) forming residues; other site 336982002305 trimer interface [polypeptide binding]; other site 336982002306 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 336982002307 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 336982002308 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 336982002309 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 336982002310 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 336982002311 ATP binding site [chemical binding]; other site 336982002312 putative Mg++ binding site [ion binding]; other site 336982002313 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 336982002314 nucleotide binding region [chemical binding]; other site 336982002315 ATP-binding site [chemical binding]; other site 336982002316 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 336982002317 WYL domain; Region: WYL; pfam13280 336982002318 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 336982002319 trimer interface [polypeptide binding]; other site 336982002320 dimer interface [polypeptide binding]; other site 336982002321 putative active site [active] 336982002322 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 336982002323 MPT binding site; other site 336982002324 trimer interface [polypeptide binding]; other site 336982002325 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 336982002326 MoaE homodimer interface [polypeptide binding]; other site 336982002327 MoaD interaction [polypeptide binding]; other site 336982002328 active site residues [active] 336982002329 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 336982002330 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 336982002331 MoaE interaction surface [polypeptide binding]; other site 336982002332 MoeB interaction surface [polypeptide binding]; other site 336982002333 thiocarboxylated glycine; other site 336982002334 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 336982002335 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 336982002336 FeS/SAM binding site; other site 336982002337 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 336982002338 hypothetical protein; Provisional; Region: PRK11770 336982002339 Domain of unknown function (DUF307); Region: DUF307; pfam03733 336982002340 Domain of unknown function (DUF307); Region: DUF307; pfam03733 336982002341 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 336982002342 DNA-binding site [nucleotide binding]; DNA binding site 336982002343 RNA-binding motif; other site 336982002344 PE family; Region: PE; pfam00934 336982002345 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 336982002346 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 336982002347 active site 336982002348 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 336982002349 FIST N domain; Region: FIST; pfam08495 336982002350 FIST C domain; Region: FIST_C; pfam10442 336982002351 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 336982002352 H+ Antiporter protein; Region: 2A0121; TIGR00900 336982002353 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 336982002354 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982002355 PPE family; Region: PPE; pfam00823 336982002356 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982002357 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982002358 Protein of unknown function (DUF2530); Region: DUF2530; pfam10745 336982002359 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 336982002360 MarR family; Region: MarR; pfam01047 336982002361 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 336982002362 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 336982002363 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 336982002364 Protein of unknown function (DUF2537); Region: DUF2537; pfam10801 336982002365 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 336982002366 phosphoserine aminotransferase, putative; Region: serC_3; TIGR01366 336982002367 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 336982002368 catalytic residue [active] 336982002369 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 336982002370 Ferredoxin [Energy production and conversion]; Region: COG1146 336982002371 4Fe-4S binding domain; Region: Fer4; pfam00037 336982002372 ferredoxin-NADP+ reductase; Region: PLN02852 336982002373 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 336982002374 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 336982002375 putative dimer interface [polypeptide binding]; other site 336982002376 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 336982002377 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 336982002378 putative catalytic site [active] 336982002379 putative phosphate binding site [ion binding]; other site 336982002380 putative metal binding site [ion binding]; other site 336982002381 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 336982002382 dimer interface [polypeptide binding]; other site 336982002383 Citrate synthase; Region: Citrate_synt; pfam00285 336982002384 active site 336982002385 citrylCoA binding site [chemical binding]; other site 336982002386 oxalacetate/citrate binding site [chemical binding]; other site 336982002387 coenzyme A binding site [chemical binding]; other site 336982002388 catalytic triad [active] 336982002389 Predicted ATPase [General function prediction only]; Region: COG3903 336982002390 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 336982002391 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 336982002392 DNA binding residues [nucleotide binding] 336982002393 dimerization interface [polypeptide binding]; other site 336982002394 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 336982002395 cyclase homology domain; Region: CHD; cd07302 336982002396 nucleotidyl binding site; other site 336982002397 metal binding site [ion binding]; metal-binding site 336982002398 dimer interface [polypeptide binding]; other site 336982002399 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 336982002400 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 336982002401 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 336982002402 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 336982002403 AAA ATPase domain; Region: AAA_16; pfam13191 336982002404 Predicted ATPase [General function prediction only]; Region: COG3903 336982002405 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 336982002406 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 336982002407 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 336982002408 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 336982002409 dimer interface [polypeptide binding]; other site 336982002410 active site 336982002411 citrylCoA binding site [chemical binding]; other site 336982002412 NADH binding [chemical binding]; other site 336982002413 cationic pore residues; other site 336982002414 oxalacetate/citrate binding site [chemical binding]; other site 336982002415 coenzyme A binding site [chemical binding]; other site 336982002416 catalytic triad [active] 336982002417 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 336982002418 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 336982002419 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 336982002420 BON domain; Region: BON; pfam04972 336982002421 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 336982002422 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 336982002423 ligand binding site [chemical binding]; other site 336982002424 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 336982002425 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 336982002426 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 336982002427 dimerization interface [polypeptide binding]; other site 336982002428 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 336982002429 dimer interface [polypeptide binding]; other site 336982002430 phosphorylation site [posttranslational modification] 336982002431 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 336982002432 Mg2+ binding site [ion binding]; other site 336982002433 G-X-G motif; other site 336982002434 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 336982002435 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 336982002436 active site 336982002437 phosphorylation site [posttranslational modification] 336982002438 intermolecular recognition site; other site 336982002439 dimerization interface [polypeptide binding]; other site 336982002440 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 336982002441 DNA binding site [nucleotide binding] 336982002442 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 336982002443 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; COG0825 336982002444 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 336982002445 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 336982002446 substrate binding site [chemical binding]; other site 336982002447 oxyanion hole (OAH) forming residues; other site 336982002448 trimer interface [polypeptide binding]; other site 336982002449 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 336982002450 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 336982002451 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 336982002452 Beta-lactamase; Region: Beta-lactamase; pfam00144 336982002453 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 336982002454 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 336982002455 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 336982002456 Soluble P-type ATPase [General function prediction only]; Region: COG4087 336982002457 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 336982002458 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 336982002459 hydrophobic ligand binding site; other site 336982002460 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 336982002461 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 336982002462 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 336982002463 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 336982002464 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 336982002465 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 336982002466 acetyl-CoA acetyltransferase; Provisional; Region: PRK06289 336982002467 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 336982002468 active site 336982002469 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982002470 PPE family; Region: PPE; pfam00823 336982002471 PE family; Region: PE; pfam00934 336982002472 BCCT family transporter; Region: BCCT; pfam02028 336982002473 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 336982002474 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 336982002475 Coenzyme A binding pocket [chemical binding]; other site 336982002476 Transposase, Mutator family; Region: Transposase_mut; pfam00872 336982002477 MULE transposase domain; Region: MULE; pfam10551 336982002478 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 336982002479 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 336982002480 catalytic residues [active] 336982002481 catalytic nucleophile [active] 336982002482 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 336982002483 Probable transposase; Region: OrfB_IS605; pfam01385 336982002484 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 336982002485 putative active site pocket [active] 336982002486 dimerization interface [polypeptide binding]; other site 336982002487 putative catalytic residue [active] 336982002488 Phage-related replication protein [General function prediction only]; Region: COG4195 336982002489 manganese transport protein MntH; Reviewed; Region: PRK00701 336982002490 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 336982002491 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 336982002492 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 336982002493 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 336982002494 short chain dehydrogenase; Provisional; Region: PRK07814 336982002495 classical (c) SDRs; Region: SDR_c; cd05233 336982002496 NAD(P) binding site [chemical binding]; other site 336982002497 active site 336982002498 phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975 336982002499 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 336982002500 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 336982002501 dimer interface [polypeptide binding]; other site 336982002502 conserved gate region; other site 336982002503 putative PBP binding loops; other site 336982002504 ABC-ATPase subunit interface; other site 336982002505 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 336982002506 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 336982002507 dimer interface [polypeptide binding]; other site 336982002508 conserved gate region; other site 336982002509 putative PBP binding loops; other site 336982002510 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 336982002511 ABC-ATPase subunit interface; other site 336982002512 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 336982002513 Catalytic domain of Protein Kinases; Region: PKc; cd00180 336982002514 active site 336982002515 ATP binding site [chemical binding]; other site 336982002516 substrate binding site [chemical binding]; other site 336982002517 activation loop (A-loop); other site 336982002518 Uncharacterized conserved protein [Function unknown]; Region: COG3391 336982002519 NHL repeat; Region: NHL; pfam01436 336982002520 NHL repeat; Region: NHL; pfam01436 336982002521 NHL repeat; Region: NHL; pfam01436 336982002522 NHL repeat; Region: NHL; pfam01436 336982002523 NHL repeat; Region: NHL; pfam01436 336982002524 PBP superfamily domain; Region: PBP_like_2; cl17296 336982002525 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14271 336982002526 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 336982002527 Walker A/P-loop; other site 336982002528 ATP binding site [chemical binding]; other site 336982002529 Q-loop/lid; other site 336982002530 ABC transporter signature motif; other site 336982002531 Walker B; other site 336982002532 D-loop; other site 336982002533 H-loop/switch region; other site 336982002534 phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975 336982002535 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 336982002536 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 336982002537 dimer interface [polypeptide binding]; other site 336982002538 conserved gate region; other site 336982002539 putative PBP binding loops; other site 336982002540 ABC-ATPase subunit interface; other site 336982002541 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 336982002542 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 336982002543 dimer interface [polypeptide binding]; other site 336982002544 conserved gate region; other site 336982002545 putative PBP binding loops; other site 336982002546 ABC-ATPase subunit interface; other site 336982002547 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 336982002548 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 336982002549 putative DNA binding site [nucleotide binding]; other site 336982002550 putative homodimer interface [polypeptide binding]; other site 336982002551 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 336982002552 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 336982002553 nucleotide binding site [chemical binding]; other site 336982002554 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 336982002555 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 336982002556 active site 336982002557 DNA binding site [nucleotide binding] 336982002558 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 336982002559 DNA binding site [nucleotide binding] 336982002560 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 336982002561 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 336982002562 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 336982002563 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 336982002564 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 336982002565 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 336982002566 anti sigma factor interaction site; other site 336982002567 regulatory phosphorylation site [posttranslational modification]; other site 336982002568 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 336982002569 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 336982002570 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 336982002571 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 336982002572 short chain dehydrogenase; Provisional; Region: PRK08251 336982002573 classical (c) SDR, subgroup 6; Region: SDR_c6; cd05350 336982002574 putative NAD(P) binding site [chemical binding]; other site 336982002575 active site 336982002576 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 336982002577 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 336982002578 active site 336982002579 dimer interface [polypeptide binding]; other site 336982002580 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 336982002581 dimer interface [polypeptide binding]; other site 336982002582 active site 336982002583 Predicted esterase [General function prediction only]; Region: COG0627 336982002584 hypothetical protein; Provisional; Region: PRK07857 336982002585 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 336982002586 Part of AAA domain; Region: AAA_19; pfam13245 336982002587 Family description; Region: UvrD_C_2; pfam13538 336982002588 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 336982002589 Peptidase family M23; Region: Peptidase_M23; pfam01551 336982002590 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 336982002591 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 336982002592 CoA-ligase; Region: Ligase_CoA; pfam00549 336982002593 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 336982002594 CoA binding domain; Region: CoA_binding; smart00881 336982002595 CoA-ligase; Region: Ligase_CoA; pfam00549 336982002596 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 336982002597 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 336982002598 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 336982002599 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 336982002600 active site 336982002601 substrate binding site [chemical binding]; other site 336982002602 cosubstrate binding site; other site 336982002603 catalytic site [active] 336982002604 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 336982002605 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 336982002606 purine monophosphate binding site [chemical binding]; other site 336982002607 dimer interface [polypeptide binding]; other site 336982002608 putative catalytic residues [active] 336982002609 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 336982002610 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 336982002611 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 336982002612 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 336982002613 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 336982002614 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 336982002615 metal ion-dependent adhesion site (MIDAS); other site 336982002616 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 336982002617 homotetrameric interface [polypeptide binding]; other site 336982002618 putative active site [active] 336982002619 metal binding site [ion binding]; metal-binding site 336982002620 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 336982002621 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 336982002622 Thermus thermophilus CsoR, a Cu(I)-sensing transcriptional regulator, and related domains; this domain family was previously known as part of DUF156; Region: TthCsoR-like_DUF156; cd10151 336982002623 putative homodimer interface [polypeptide binding]; other site 336982002624 putative homotetramer interface [polypeptide binding]; other site 336982002625 allosteric switch controlling residues; other site 336982002626 putative metal binding site [ion binding]; other site 336982002627 putative homodimer-homodimer interface [polypeptide binding]; other site 336982002628 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 336982002629 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 336982002630 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 336982002631 Soluble P-type ATPase [General function prediction only]; Region: COG4087 336982002632 enoyl-CoA hydratase; Provisional; Region: PRK07827 336982002633 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 336982002634 substrate binding site [chemical binding]; other site 336982002635 oxyanion hole (OAH) forming residues; other site 336982002636 trimer interface [polypeptide binding]; other site 336982002637 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 336982002638 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 336982002639 active site 336982002640 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 336982002641 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 336982002642 ATP-grasp domain; Region: ATP-grasp_4; cl17255 336982002643 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 336982002644 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 336982002645 carboxyltransferase (CT) interaction site; other site 336982002646 biotinylation site [posttranslational modification]; other site 336982002647 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 336982002648 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 336982002649 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 336982002650 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 336982002651 active site 336982002652 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 336982002653 PE family; Region: PE; pfam00934 336982002654 PE family; Region: PE; pfam00934 336982002655 Uncharacterized conserved protein [Function unknown]; Region: COG3391 336982002656 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 336982002657 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 336982002658 PE family; Region: PE; pfam00934 336982002659 Uncharacterized conserved protein [Function unknown]; Region: COG3391 336982002660 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 336982002661 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 336982002662 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 336982002663 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 336982002664 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 336982002665 active site 336982002666 phosphorylation site [posttranslational modification] 336982002667 intermolecular recognition site; other site 336982002668 dimerization interface [polypeptide binding]; other site 336982002669 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 336982002670 DNA binding site [nucleotide binding] 336982002671 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 336982002672 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 336982002673 dimerization interface [polypeptide binding]; other site 336982002674 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 336982002675 dimer interface [polypeptide binding]; other site 336982002676 phosphorylation site [posttranslational modification] 336982002677 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 336982002678 ATP binding site [chemical binding]; other site 336982002679 Mg2+ binding site [ion binding]; other site 336982002680 G-X-G motif; other site 336982002681 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 336982002682 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 336982002683 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 336982002684 MPT binding site; other site 336982002685 trimer interface [polypeptide binding]; other site 336982002686 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 336982002687 Large-conductance mechanosensitive channel, MscL; Region: MscL; pfam01741 336982002688 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 336982002689 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 336982002690 Walker A/P-loop; other site 336982002691 ATP binding site [chemical binding]; other site 336982002692 Q-loop/lid; other site 336982002693 ABC transporter signature motif; other site 336982002694 Walker B; other site 336982002695 D-loop; other site 336982002696 H-loop/switch region; other site 336982002697 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 336982002698 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 336982002699 FtsX-like permease family; Region: FtsX; pfam02687 336982002700 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 336982002701 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 336982002702 FtsX-like permease family; Region: FtsX; pfam02687 336982002703 Predicted secreted hydrolase [General function prediction only]; Region: COG5621 336982002704 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 336982002705 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 336982002706 substrate binding pocket [chemical binding]; other site 336982002707 chain length determination region; other site 336982002708 substrate-Mg2+ binding site; other site 336982002709 catalytic residues [active] 336982002710 aspartate-rich region 1; other site 336982002711 active site lid residues [active] 336982002712 aspartate-rich region 2; other site 336982002713 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 336982002714 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2331 336982002715 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 336982002716 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 336982002717 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 336982002718 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 336982002719 active site 336982002720 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 336982002721 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 336982002722 dimer interface [polypeptide binding]; other site 336982002723 putative functional site; other site 336982002724 putative MPT binding site; other site 336982002725 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 336982002726 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 336982002727 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 336982002728 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 336982002729 ligand binding site [chemical binding]; other site 336982002730 flexible hinge region; other site 336982002731 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 336982002732 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 336982002733 Coenzyme A binding pocket [chemical binding]; other site 336982002734 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 336982002735 arginine deiminase; Provisional; Region: PRK01388 336982002736 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 336982002737 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 336982002738 Predicted methyltransferases [General function prediction only]; Region: COG0313 336982002739 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 336982002740 putative SAM binding site [chemical binding]; other site 336982002741 putative homodimer interface [polypeptide binding]; other site 336982002742 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 336982002743 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 336982002744 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 336982002745 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 336982002746 active site 336982002747 HIGH motif; other site 336982002748 KMSKS motif; other site 336982002749 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 336982002750 tRNA binding surface [nucleotide binding]; other site 336982002751 anticodon binding site; other site 336982002752 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 336982002753 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 336982002754 active site 336982002755 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 336982002756 Domain of unknown function (DUF348); Region: DUF348; pfam03990 336982002757 Domain of unknown function (DUF348); Region: DUF348; pfam03990 336982002758 G5 domain; Region: G5; pfam07501 336982002759 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 336982002760 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 336982002761 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 336982002762 S-adenosylmethionine binding site [chemical binding]; other site 336982002763 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 336982002764 Increased loss of mitochondrial DNA protein 1; Region: Ilm1; pfam10311 336982002765 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 336982002766 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 336982002767 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 336982002768 acyl-activating enzyme (AAE) consensus motif; other site 336982002769 AMP binding site [chemical binding]; other site 336982002770 active site 336982002771 CoA binding site [chemical binding]; other site 336982002772 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 336982002773 putative active site [active] 336982002774 catalytic residue [active] 336982002775 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 336982002776 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 336982002777 5S rRNA interface [nucleotide binding]; other site 336982002778 CTC domain interface [polypeptide binding]; other site 336982002779 L16 interface [polypeptide binding]; other site 336982002780 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 336982002781 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 336982002782 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 336982002783 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 336982002784 active site 336982002785 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 336982002786 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 336982002787 Substrate binding site; other site 336982002788 Mg++ binding site; other site 336982002789 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 336982002790 active site 336982002791 substrate binding site [chemical binding]; other site 336982002792 CoA binding site [chemical binding]; other site 336982002793 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982002794 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982002795 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 336982002796 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 336982002797 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 336982002798 ATP binding site [chemical binding]; other site 336982002799 putative Mg++ binding site [ion binding]; other site 336982002800 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 336982002801 nucleotide binding region [chemical binding]; other site 336982002802 ATP-binding site [chemical binding]; other site 336982002803 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 336982002804 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 336982002805 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 336982002806 homodimer interface [polypeptide binding]; other site 336982002807 metal binding site [ion binding]; metal-binding site 336982002808 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 336982002809 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 336982002810 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 336982002811 N-acetyl-D-glucosamine binding site [chemical binding]; other site 336982002812 enolase; Provisional; Region: eno; PRK00077 336982002813 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 336982002814 dimer interface [polypeptide binding]; other site 336982002815 metal binding site [ion binding]; metal-binding site 336982002816 substrate binding pocket [chemical binding]; other site 336982002817 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 336982002818 Septum formation initiator; Region: DivIC; pfam04977 336982002819 Uncharacterized conserved protein [Function unknown]; Region: COG1507 336982002820 exopolyphosphatase; Region: exo_poly_only; TIGR03706 336982002821 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 336982002822 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 336982002823 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 336982002824 active site 336982002825 phosphorylation site [posttranslational modification] 336982002826 intermolecular recognition site; other site 336982002827 dimerization interface [polypeptide binding]; other site 336982002828 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 336982002829 DNA binding site [nucleotide binding] 336982002830 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 336982002831 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 336982002832 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 336982002833 Ligand Binding Site [chemical binding]; other site 336982002834 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 336982002835 dimer interface [polypeptide binding]; other site 336982002836 phosphorylation site [posttranslational modification] 336982002837 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 336982002838 ATP binding site [chemical binding]; other site 336982002839 Mg2+ binding site [ion binding]; other site 336982002840 G-X-G motif; other site 336982002841 K+-transporting ATPase, KdpA; Region: kdpA; TIGR00680 336982002842 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 336982002843 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 336982002844 Soluble P-type ATPase [General function prediction only]; Region: COG4087 336982002845 potassium-transporting ATPase subunit C; Provisional; Region: PRK14001 336982002846 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 336982002847 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 336982002848 dimer interface [polypeptide binding]; other site 336982002849 phosphorylation site [posttranslational modification] 336982002850 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 336982002851 ATP binding site [chemical binding]; other site 336982002852 Mg2+ binding site [ion binding]; other site 336982002853 G-X-G motif; other site 336982002854 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 336982002855 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 336982002856 active site 336982002857 phosphorylation site [posttranslational modification] 336982002858 intermolecular recognition site; other site 336982002859 dimerization interface [polypeptide binding]; other site 336982002860 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 336982002861 DNA binding site [nucleotide binding] 336982002862 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 336982002863 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 336982002864 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 336982002865 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 336982002866 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 336982002867 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982002868 PPE family; Region: PPE; pfam00823 336982002869 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 336982002870 PE family; Region: PE; pfam00934 336982002871 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 336982002872 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 336982002873 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 336982002874 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 336982002875 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 336982002876 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 336982002877 Predicted transcriptional regulator [Transcription]; Region: COG5340 336982002878 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 336982002879 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 336982002880 Transposase, Mutator family; Region: Transposase_mut; pfam00872 336982002881 MULE transposase domain; Region: MULE; pfam10551 336982002882 Transcriptional regulators [Transcription]; Region: MarR; COG1846 336982002883 MarR family; Region: MarR_2; pfam12802 336982002884 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982002885 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 336982002886 NAD(P) binding site [chemical binding]; other site 336982002887 active site 336982002888 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 336982002889 Helix-turn-helix domain; Region: HTH_17; pfam12728 336982002890 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 336982002891 Domain of unknown function (DUF427); Region: DUF427; cl00998 336982002892 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 336982002893 Uncharacterized conserved protein [Function unknown]; Region: COG3391 336982002894 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 336982002895 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 336982002896 dimer interface [polypeptide binding]; other site 336982002897 acyl-activating enzyme (AAE) consensus motif; other site 336982002898 putative active site [active] 336982002899 AMP binding site [chemical binding]; other site 336982002900 putative CoA binding site [chemical binding]; other site 336982002901 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 336982002902 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 336982002903 hydrophobic ligand binding site; other site 336982002904 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 336982002905 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 336982002906 putative active site [active] 336982002907 putative dimer interface [polypeptide binding]; other site 336982002908 Patatin-like phospholipase; Region: Patatin; pfam01734 336982002909 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 336982002910 nucleophile elbow; other site 336982002911 hypothetical protein; Provisional; Region: PRK10279 336982002912 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 336982002913 active site 336982002914 nucleophile elbow; other site 336982002915 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 336982002916 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 336982002917 active site residue [active] 336982002918 PE family; Region: PE; pfam00934 336982002919 PE family; Region: PE; pfam00934 336982002920 Predicted membrane protein [Function unknown]; Region: COG4425 336982002921 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 336982002922 enoyl-CoA hydratase; Provisional; Region: PRK05862 336982002923 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 336982002924 substrate binding site [chemical binding]; other site 336982002925 oxyanion hole (OAH) forming residues; other site 336982002926 trimer interface [polypeptide binding]; other site 336982002927 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 336982002928 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 336982002929 substrate binding site [chemical binding]; other site 336982002930 oxyanion hole (OAH) forming residues; other site 336982002931 trimer interface [polypeptide binding]; other site 336982002932 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 336982002933 Predicted membrane protein [Function unknown]; Region: COG4760 336982002934 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 336982002935 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 336982002936 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 336982002937 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 336982002938 dimer interface [polypeptide binding]; other site 336982002939 active site 336982002940 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 336982002941 active site 336982002942 catalytic triad [active] 336982002943 oxyanion hole [active] 336982002944 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 336982002945 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 336982002946 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 336982002947 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 336982002948 dimer interface [polypeptide binding]; other site 336982002949 pyridoxal 5'-phosphate binding site [chemical binding]; other site 336982002950 catalytic residue [active] 336982002951 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 336982002952 RDD family; Region: RDD; pfam06271 336982002953 cystathionine gamma-synthase; Provisional; Region: PRK07811 336982002954 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 336982002955 homodimer interface [polypeptide binding]; other site 336982002956 substrate-cofactor binding pocket; other site 336982002957 pyridoxal 5'-phosphate binding site [chemical binding]; other site 336982002958 catalytic residue [active] 336982002959 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 336982002960 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 336982002961 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 336982002962 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 336982002963 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 336982002964 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 336982002965 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 336982002966 catalytic residues [active] 336982002967 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 336982002968 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 336982002969 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 336982002970 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 336982002971 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 336982002972 catalytic residue [active] 336982002973 putative FPP diphosphate binding site; other site 336982002974 putative FPP binding hydrophobic cleft; other site 336982002975 dimer interface [polypeptide binding]; other site 336982002976 putative IPP diphosphate binding site; other site 336982002977 PE family; Region: PE; pfam00934 336982002978 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 336982002979 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 336982002980 putative IPP diphosphate binding site; other site 336982002981 PE family; Region: PE; pfam00934 336982002982 Glycosyl hydrolase family 12; Region: Glyco_hydro_12; pfam01670 336982002983 PE family; Region: PE; pfam00934 336982002984 pantothenate kinase; Provisional; Region: PRK05439 336982002985 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 336982002986 ATP-binding site [chemical binding]; other site 336982002987 CoA-binding site [chemical binding]; other site 336982002988 Mg2+-binding site [ion binding]; other site 336982002989 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 336982002990 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 336982002991 dimer interface [polypeptide binding]; other site 336982002992 active site 336982002993 glycine-pyridoxal phosphate binding site [chemical binding]; other site 336982002994 folate binding site [chemical binding]; other site 336982002995 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 336982002996 dinuclear metal binding motif [ion binding]; other site 336982002997 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 336982002998 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 336982002999 putative active site [active] 336982003000 PhoH-like protein; Region: PhoH; pfam02562 336982003001 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 336982003002 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 336982003003 NodB motif; other site 336982003004 active site 336982003005 catalytic site [active] 336982003006 metal binding site [ion binding]; metal-binding site 336982003007 fumarate hydratase; Reviewed; Region: fumC; PRK00485 336982003008 Class II fumarases; Region: Fumarase_classII; cd01362 336982003009 active site 336982003010 tetramer interface [polypeptide binding]; other site 336982003011 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 336982003012 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 336982003013 putative active site [active] 336982003014 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 336982003015 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 336982003016 Domain of unknown function DUF20; Region: UPF0118; pfam01594 336982003017 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 336982003018 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 336982003019 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 336982003020 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 336982003021 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 336982003022 3beta-hydroxysteroid dehydrogenases (3b-HSD)-like, extended (e) SDRs; Region: 3b-HSD-like_SDR_e; cd05241 336982003023 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 336982003024 putative NAD(P) binding site [chemical binding]; other site 336982003025 active site 336982003026 putative substrate binding site [chemical binding]; other site 336982003027 exodeoxyribonuclease VII, small subunit; Region: xseB; TIGR01280 336982003028 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 336982003029 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 336982003030 generic binding surface II; other site 336982003031 generic binding surface I; other site 336982003032 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 336982003033 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 336982003034 Yip1 domain; Region: Yip1; pfam04893 336982003035 GTP-binding protein YchF; Reviewed; Region: PRK09601 336982003036 YchF GTPase; Region: YchF; cd01900 336982003037 G1 box; other site 336982003038 GTP/Mg2+ binding site [chemical binding]; other site 336982003039 Switch I region; other site 336982003040 G2 box; other site 336982003041 Switch II region; other site 336982003042 G3 box; other site 336982003043 G4 box; other site 336982003044 G5 box; other site 336982003045 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 336982003046 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 336982003047 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487 336982003048 putative active site [active] 336982003049 Uncharacterized conserved protein [Function unknown]; Region: COG1359 336982003050 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 336982003051 cyclase homology domain; Region: CHD; cd07302 336982003052 nucleotidyl binding site; other site 336982003053 metal binding site [ion binding]; metal-binding site 336982003054 dimer interface [polypeptide binding]; other site 336982003055 glucose-6-phosphate 1-dehydrogenase; Region: zwf; TIGR00871 336982003056 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 336982003057 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 336982003058 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 336982003059 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd_rel; TIGR00872 336982003060 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 336982003061 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 336982003062 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 336982003063 pyruvate phosphate dikinase; Provisional; Region: PRK05878 336982003064 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 336982003065 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 336982003066 Domain of unknown function (DUF222); Region: DUF222; pfam02720 336982003067 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 336982003068 active site 336982003069 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 336982003070 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 336982003071 non-specific DNA binding site [nucleotide binding]; other site 336982003072 salt bridge; other site 336982003073 sequence-specific DNA binding site [nucleotide binding]; other site 336982003074 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 336982003075 Domain of unknown function (DUF955); Region: DUF955; pfam06114 336982003076 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 336982003077 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 336982003078 citrate synthase; Provisional; Region: PRK14033 336982003079 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 336982003080 oxalacetate binding site [chemical binding]; other site 336982003081 citrylCoA binding site [chemical binding]; other site 336982003082 coenzyme A binding site [chemical binding]; other site 336982003083 catalytic triad [active] 336982003084 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 336982003085 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 336982003086 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 336982003087 THF binding site; other site 336982003088 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 336982003089 substrate binding site [chemical binding]; other site 336982003090 THF binding site; other site 336982003091 zinc-binding site [ion binding]; other site 336982003092 PPE family; Region: PPE; pfam00823 336982003093 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982003094 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 336982003095 active site 336982003096 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 336982003097 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 336982003098 substrate binding site [chemical binding]; other site 336982003099 oxyanion hole (OAH) forming residues; other site 336982003100 enoyl-CoA hydratase; Provisional; Region: PRK06494 336982003101 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 336982003102 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 336982003103 CAAX protease self-immunity; Region: Abi; pfam02517 336982003104 enoyl-CoA hydratase; Provisional; Region: PRK06688 336982003105 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 336982003106 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 336982003107 trimer interface [polypeptide binding]; other site 336982003108 enoyl-CoA hydratase; Provisional; Region: PRK06688 336982003109 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 336982003110 substrate binding site [chemical binding]; other site 336982003111 oxyanion hole (OAH) forming residues; other site 336982003112 trimer interface [polypeptide binding]; other site 336982003113 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 336982003114 CoA-transferase family III; Region: CoA_transf_3; pfam02515 336982003115 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 336982003116 NAD binding site [chemical binding]; other site 336982003117 homodimer interface [polypeptide binding]; other site 336982003118 homotetramer interface [polypeptide binding]; other site 336982003119 active site 336982003120 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 336982003121 MMPL family; Region: MMPL; pfam03176 336982003122 DDE superfamily endonuclease; Region: DDE_5; cl17874 336982003123 Domain of unknown function (DUF222); Region: DUF222; pfam02720 336982003124 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 336982003125 active site 336982003126 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 336982003127 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 336982003128 NAD-dependent deacetylase; Provisional; Region: PRK00481 336982003129 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 336982003130 NAD+ binding site [chemical binding]; other site 336982003131 substrate binding site [chemical binding]; other site 336982003132 Zn binding site [ion binding]; other site 336982003133 Predicted transcriptional regulators [Transcription]; Region: COG1725 336982003134 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 336982003135 DNA-binding site [nucleotide binding]; DNA binding site 336982003136 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 336982003137 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 336982003138 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 336982003139 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 336982003140 uncharacterized HhH-GPD family protein; Region: TIGR03252 336982003141 minor groove reading motif; other site 336982003142 helix-hairpin-helix signature motif; other site 336982003143 mannosyltransferase; Provisional; Region: pimE; PRK13375 336982003144 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 336982003145 aromatic arch; other site 336982003146 DCoH dimer interaction site [polypeptide binding]; other site 336982003147 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 336982003148 DCoH tetramer interaction site [polypeptide binding]; other site 336982003149 substrate binding site [chemical binding]; other site 336982003150 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 336982003151 active site 336982003152 8-oxo-dGMP binding site [chemical binding]; other site 336982003153 nudix motif; other site 336982003154 metal binding site [ion binding]; metal-binding site 336982003155 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 336982003156 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 336982003157 [4Fe-4S] binding site [ion binding]; other site 336982003158 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 336982003159 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 336982003160 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 336982003161 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 336982003162 molybdopterin cofactor binding site; other site 336982003163 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 336982003164 nitrate reductase molybdenum cofactor assembly chaperone; Region: narJ; TIGR00684 336982003165 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 336982003166 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 336982003167 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 336982003168 G1 box; other site 336982003169 putative GEF interaction site [polypeptide binding]; other site 336982003170 GTP/Mg2+ binding site [chemical binding]; other site 336982003171 Switch I region; other site 336982003172 G2 box; other site 336982003173 G3 box; other site 336982003174 Switch II region; other site 336982003175 G4 box; other site 336982003176 G5 box; other site 336982003177 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 336982003178 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 336982003179 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 336982003180 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 336982003181 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 336982003182 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982003183 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982003184 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982003185 PPE family; Region: PPE; pfam00823 336982003186 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 336982003187 PE family; Region: PE; pfam00934 336982003188 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 336982003189 PE family; Region: PE; pfam00934 336982003190 FO synthase; Reviewed; Region: fbiC; PRK09234 336982003191 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 336982003192 FeS/SAM binding site; other site 336982003193 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 336982003194 FeS/SAM binding site; other site 336982003195 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 336982003196 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 336982003197 active site 336982003198 FMN binding site [chemical binding]; other site 336982003199 2,4-decadienoyl-CoA binding site; other site 336982003200 catalytic residue [active] 336982003201 4Fe-4S cluster binding site [ion binding]; other site 336982003202 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 336982003203 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 336982003204 Predicted transcriptional regulators [Transcription]; Region: COG1695 336982003205 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 336982003206 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 336982003207 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 336982003208 4Fe-4S binding domain; Region: Fer4; pfam00037 336982003209 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 336982003210 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 336982003211 pyridoxal 5'-phosphate binding site [chemical binding]; other site 336982003212 homodimer interface [polypeptide binding]; other site 336982003213 catalytic residue [active] 336982003214 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 336982003215 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 336982003216 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 336982003217 ATP binding site [chemical binding]; other site 336982003218 putative Mg++ binding site [ion binding]; other site 336982003219 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 336982003220 ATP-binding site [chemical binding]; other site 336982003221 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 336982003222 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 336982003223 active site 336982003224 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 336982003225 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 336982003226 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982003227 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 336982003228 Enoylreductase; Region: PKS_ER; smart00829 336982003229 NAD(P) binding site [chemical binding]; other site 336982003230 KR domain; Region: KR; pfam08659 336982003231 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 336982003232 putative NADP binding site [chemical binding]; other site 336982003233 active site 336982003234 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 336982003235 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 336982003236 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 336982003237 PE-PPE domain; Region: PE-PPE; pfam08237 336982003238 acyl-CoA synthetase; Validated; Region: PRK05850 336982003239 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 336982003240 acyl-activating enzyme (AAE) consensus motif; other site 336982003241 active site 336982003242 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 336982003243 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 336982003244 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 336982003245 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 336982003246 Glutamate binding site [chemical binding]; other site 336982003247 NAD binding site [chemical binding]; other site 336982003248 catalytic residues [active] 336982003249 Proline dehydrogenase; Region: Pro_dh; pfam01619 336982003250 RNA polymerase sigma factor SigI; Provisional; Region: sigI; PRK09635 336982003251 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 336982003252 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 336982003253 DNA binding residues [nucleotide binding] 336982003254 haloalkane dehalogenase; Provisional; Region: PRK03204 336982003255 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 336982003256 catalytic site [active] 336982003257 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 336982003258 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 336982003259 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 336982003260 PGAP1-like protein; Region: PGAP1; pfam07819 336982003261 acyl-CoA synthetase; Validated; Region: PRK07787 336982003262 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 336982003263 acyl-activating enzyme (AAE) consensus motif; other site 336982003264 AMP binding site [chemical binding]; other site 336982003265 active site 336982003266 CoA binding site [chemical binding]; other site 336982003267 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 336982003268 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 336982003269 PE family; Region: PE; pfam00934 336982003270 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982003271 PPE family; Region: PPE; pfam00823 336982003272 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 336982003273 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 336982003274 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 336982003275 Transposase, Mutator family; Region: Transposase_mut; pfam00872 336982003276 MULE transposase domain; Region: MULE; pfam10551 336982003277 metabolite-proton symporter; Region: 2A0106; TIGR00883 336982003278 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 336982003279 putative substrate translocation pore; other site 336982003280 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 336982003281 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 336982003282 putative trimer interface [polypeptide binding]; other site 336982003283 putative CoA binding site [chemical binding]; other site 336982003284 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 336982003285 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 336982003286 metal binding site [ion binding]; metal-binding site 336982003287 putative dimer interface [polypeptide binding]; other site 336982003288 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 336982003289 TIGR00730 family protein; Region: TIGR00730 336982003290 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 336982003291 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 336982003292 acyl-activating enzyme (AAE) consensus motif; other site 336982003293 putative AMP binding site [chemical binding]; other site 336982003294 putative active site [active] 336982003295 putative CoA binding site [chemical binding]; other site 336982003296 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 336982003297 dihydropteroate synthase; Region: DHPS; TIGR01496 336982003298 substrate binding pocket [chemical binding]; other site 336982003299 dimer interface [polypeptide binding]; other site 336982003300 inhibitor binding site; inhibition site 336982003301 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 336982003302 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 336982003303 DivIVA domain; Region: DivI1A_domain; TIGR03544 336982003304 DNA-3-methyladenine glycosylase I; Region: tag; TIGR00624 336982003305 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 336982003306 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 336982003307 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 336982003308 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 336982003309 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 336982003310 ligand binding site; other site 336982003311 oligomer interface; other site 336982003312 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 336982003313 dimer interface [polypeptide binding]; other site 336982003314 N-terminal domain interface [polypeptide binding]; other site 336982003315 sulfate 1 binding site; other site 336982003316 PE family; Region: PE; pfam00934 336982003317 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 336982003318 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 336982003319 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 336982003320 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 336982003321 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 336982003322 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 336982003323 Walker A/P-loop; other site 336982003324 ATP binding site [chemical binding]; other site 336982003325 Q-loop/lid; other site 336982003326 ABC transporter signature motif; other site 336982003327 Walker B; other site 336982003328 D-loop; other site 336982003329 H-loop/switch region; other site 336982003330 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 336982003331 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982003332 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 336982003333 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 336982003334 S-adenosylmethionine binding site [chemical binding]; other site 336982003335 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 336982003336 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 336982003337 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 336982003338 DNA binding residues [nucleotide binding] 336982003339 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 336982003340 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 336982003341 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 336982003342 protein binding site [polypeptide binding]; other site 336982003343 sec-independent translocase; Provisional; Region: PRK03100 336982003344 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 336982003345 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 336982003346 active site 336982003347 motif I; other site 336982003348 motif II; other site 336982003349 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 336982003350 Predicted membrane protein [Function unknown]; Region: COG3428 336982003351 Bacterial PH domain; Region: DUF304; pfam03703 336982003352 Uncharacterized conserved protein [Function unknown]; Region: COG3402 336982003353 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 336982003354 Domain of unknown function DUF59; Region: DUF59; cl00941 336982003355 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 336982003356 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 336982003357 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 336982003358 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 336982003359 N-acetyl-D-glucosamine binding site [chemical binding]; other site 336982003360 catalytic residue [active] 336982003361 Predicted membrane protein [Function unknown]; Region: COG4420 336982003362 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 336982003363 MgtE intracellular N domain; Region: MgtE_N; smart00924 336982003364 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 336982003365 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 336982003366 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 336982003367 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 336982003368 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 336982003369 dimer interface [polypeptide binding]; other site 336982003370 conserved gate region; other site 336982003371 putative PBP binding loops; other site 336982003372 ABC-ATPase subunit interface; other site 336982003373 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 336982003374 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 336982003375 dimer interface [polypeptide binding]; other site 336982003376 conserved gate region; other site 336982003377 ABC-ATPase subunit interface; other site 336982003378 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 336982003379 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 336982003380 Walker A/P-loop; other site 336982003381 ATP binding site [chemical binding]; other site 336982003382 Q-loop/lid; other site 336982003383 ABC transporter signature motif; other site 336982003384 Walker B; other site 336982003385 D-loop; other site 336982003386 H-loop/switch region; other site 336982003387 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 336982003388 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 336982003389 oligomer interface [polypeptide binding]; other site 336982003390 metal binding site [ion binding]; metal-binding site 336982003391 metal binding site [ion binding]; metal-binding site 336982003392 putative Cl binding site [ion binding]; other site 336982003393 basic sphincter; other site 336982003394 hydrophobic gate; other site 336982003395 periplasmic entrance; other site 336982003396 malate dehydrogenase; Provisional; Region: PRK05442 336982003397 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 336982003398 NAD(P) binding site [chemical binding]; other site 336982003399 dimer interface [polypeptide binding]; other site 336982003400 malate binding site [chemical binding]; other site 336982003401 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 336982003402 PE family; Region: PE; pfam00934 336982003403 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 336982003404 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 336982003405 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982003406 NAD(P) binding site [chemical binding]; other site 336982003407 active site 336982003408 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 336982003409 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 336982003410 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 336982003411 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 336982003412 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 336982003413 TPP-binding site [chemical binding]; other site 336982003414 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 336982003415 dimer interface [polypeptide binding]; other site 336982003416 PYR/PP interface [polypeptide binding]; other site 336982003417 TPP binding site [chemical binding]; other site 336982003418 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 336982003419 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 336982003420 putative substrate translocation pore; other site 336982003421 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 336982003422 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 336982003423 RNase_H superfamily; Region: RNase_H_2; pfam13482 336982003424 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 336982003425 Part of AAA domain; Region: AAA_19; pfam13245 336982003426 AAA domain; Region: AAA_12; pfam13087 336982003427 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 336982003428 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 336982003429 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 336982003430 ATP binding site [chemical binding]; other site 336982003431 Mg++ binding site [ion binding]; other site 336982003432 motif III; other site 336982003433 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 336982003434 nucleotide binding region [chemical binding]; other site 336982003435 ATP-binding site [chemical binding]; other site 336982003436 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 336982003437 putative RNA binding site [nucleotide binding]; other site 336982003438 Acyltransferase family; Region: Acyl_transf_3; pfam01757 336982003439 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982003440 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982003441 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 336982003442 FAD binding domain; Region: FAD_binding_4; pfam01565 336982003443 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 336982003444 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 336982003445 H+ Antiporter protein; Region: 2A0121; TIGR00900 336982003446 putative substrate translocation pore; other site 336982003447 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 336982003448 Fe-S cluster binding site [ion binding]; other site 336982003449 DNA binding site [nucleotide binding] 336982003450 active site 336982003451 hypothetical protein; Validated; Region: PRK05868 336982003452 hypothetical protein; Provisional; Region: PRK07236 336982003453 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 336982003454 Domain of unknown function (DUF385); Region: DUF385; pfam04075 336982003455 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 336982003456 HIT family signature motif; other site 336982003457 catalytic residue [active] 336982003458 amidase; Provisional; Region: PRK12470 336982003459 Amidase; Region: Amidase; pfam01425 336982003460 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 336982003461 cyclase homology domain; Region: CHD; cd07302 336982003462 nucleotidyl binding site; other site 336982003463 metal binding site [ion binding]; metal-binding site 336982003464 dimer interface [polypeptide binding]; other site 336982003465 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 336982003466 Catalytic domain of Protein Kinases; Region: PKc; cd00180 336982003467 active site 336982003468 ATP binding site [chemical binding]; other site 336982003469 substrate binding site [chemical binding]; other site 336982003470 activation loop (A-loop); other site 336982003471 PknH-like extracellular domain; Region: PknH_C; pfam14032 336982003472 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 336982003473 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 336982003474 DNA binding site [nucleotide binding] 336982003475 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 336982003476 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 336982003477 phosphopeptide binding site; other site 336982003478 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 336982003479 putative active site [active] 336982003480 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 336982003481 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 336982003482 Protein of unknown function (DUF732); Region: DUF732; pfam05305 336982003483 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 336982003484 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 336982003485 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 336982003486 Walker A/P-loop; other site 336982003487 ATP binding site [chemical binding]; other site 336982003488 Q-loop/lid; other site 336982003489 ABC transporter signature motif; other site 336982003490 Walker B; other site 336982003491 D-loop; other site 336982003492 H-loop/switch region; other site 336982003493 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 336982003494 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 336982003495 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 336982003496 Walker A/P-loop; other site 336982003497 ATP binding site [chemical binding]; other site 336982003498 Q-loop/lid; other site 336982003499 ABC transporter signature motif; other site 336982003500 Walker B; other site 336982003501 D-loop; other site 336982003502 H-loop/switch region; other site 336982003503 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 336982003504 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 336982003505 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 336982003506 catalytic core [active] 336982003507 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 336982003508 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 336982003509 active site 336982003510 metal binding site [ion binding]; metal-binding site 336982003511 DNA binding site [nucleotide binding] 336982003512 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 336982003513 Walker A/P-loop; other site 336982003514 ATP binding site [chemical binding]; other site 336982003515 choline dehydrogenase; Validated; Region: PRK02106 336982003516 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 336982003517 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 336982003518 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 336982003519 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 336982003520 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 336982003521 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 336982003522 Walker A/P-loop; other site 336982003523 ATP binding site [chemical binding]; other site 336982003524 Q-loop/lid; other site 336982003525 ABC transporter signature motif; other site 336982003526 Walker B; other site 336982003527 D-loop; other site 336982003528 H-loop/switch region; other site 336982003529 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 336982003530 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 336982003531 Walker A/P-loop; other site 336982003532 ATP binding site [chemical binding]; other site 336982003533 Q-loop/lid; other site 336982003534 ABC transporter signature motif; other site 336982003535 Walker B; other site 336982003536 D-loop; other site 336982003537 H-loop/switch region; other site 336982003538 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 336982003539 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 336982003540 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 336982003541 dimer interface [polypeptide binding]; other site 336982003542 conserved gate region; other site 336982003543 putative PBP binding loops; other site 336982003544 ABC-ATPase subunit interface; other site 336982003545 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 336982003546 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 336982003547 dimer interface [polypeptide binding]; other site 336982003548 conserved gate region; other site 336982003549 putative PBP binding loops; other site 336982003550 ABC-ATPase subunit interface; other site 336982003551 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 336982003552 active site clefts [active] 336982003553 zinc binding site [ion binding]; other site 336982003554 dimer interface [polypeptide binding]; other site 336982003555 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 336982003556 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 336982003557 Active Sites [active] 336982003558 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 336982003559 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 336982003560 CysD dimerization site [polypeptide binding]; other site 336982003561 G1 box; other site 336982003562 putative GEF interaction site [polypeptide binding]; other site 336982003563 GTP/Mg2+ binding site [chemical binding]; other site 336982003564 Switch I region; other site 336982003565 G2 box; other site 336982003566 G3 box; other site 336982003567 Switch II region; other site 336982003568 G4 box; other site 336982003569 G5 box; other site 336982003570 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 336982003571 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 336982003572 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 336982003573 ligand-binding site [chemical binding]; other site 336982003574 Rrf2 family protein; Region: rrf2_super; TIGR00738 336982003575 Transcriptional regulator; Region: Rrf2; pfam02082 336982003576 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 336982003577 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 336982003578 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 336982003579 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 336982003580 Putative esterase; Region: Esterase; pfam00756 336982003581 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 336982003582 Predicted membrane protein [Function unknown]; Region: COG4325 336982003583 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 336982003584 Protein of unknown function (DUF732); Region: DUF732; pfam05305 336982003585 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 336982003586 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 336982003587 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 336982003588 active site 336982003589 HIGH motif; other site 336982003590 KMSK motif region; other site 336982003591 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 336982003592 tRNA binding surface [nucleotide binding]; other site 336982003593 anticodon binding site; other site 336982003594 diaminopimelate decarboxylase; Region: lysA; TIGR01048 336982003595 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 336982003596 active site 336982003597 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 336982003598 substrate binding site [chemical binding]; other site 336982003599 catalytic residues [active] 336982003600 dimer interface [polypeptide binding]; other site 336982003601 homoserine dehydrogenase; Provisional; Region: PRK06349 336982003602 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 336982003603 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 336982003604 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 336982003605 threonine synthase; Reviewed; Region: PRK06721 336982003606 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 336982003607 homodimer interface [polypeptide binding]; other site 336982003608 pyridoxal 5'-phosphate binding site [chemical binding]; other site 336982003609 catalytic residue [active] 336982003610 Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083 336982003611 transcription termination factor Rho; Provisional; Region: PRK12678 336982003612 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 336982003613 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 336982003614 RNA binding site [nucleotide binding]; other site 336982003615 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 336982003616 multimer interface [polypeptide binding]; other site 336982003617 Walker A motif; other site 336982003618 ATP binding site [chemical binding]; other site 336982003619 Walker B motif; other site 336982003620 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 336982003621 peptide chain release factor 1; Region: prfA; TIGR00019 336982003622 This domain is found in peptide chain release factors; Region: PCRF; smart00937 336982003623 RF-1 domain; Region: RF-1; pfam00472 336982003624 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 336982003625 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 336982003626 S-adenosylmethionine binding site [chemical binding]; other site 336982003627 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 336982003628 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 336982003629 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 336982003630 Mg++ binding site [ion binding]; other site 336982003631 putative catalytic motif [active] 336982003632 substrate binding site [chemical binding]; other site 336982003633 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 336982003634 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 336982003635 F0F1 ATP synthase subunit C; Validated; Region: PRK05880 336982003636 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 336982003637 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 336982003638 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13428 336982003639 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 336982003640 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 336982003641 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 336982003642 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 336982003643 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 336982003644 Walker A motif; other site 336982003645 ATP binding site [chemical binding]; other site 336982003646 Walker B motif; other site 336982003647 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 336982003648 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 336982003649 core domain interface [polypeptide binding]; other site 336982003650 delta subunit interface [polypeptide binding]; other site 336982003651 epsilon subunit interface [polypeptide binding]; other site 336982003652 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 336982003653 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 336982003654 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 336982003655 alpha subunit interaction interface [polypeptide binding]; other site 336982003656 Walker A motif; other site 336982003657 ATP binding site [chemical binding]; other site 336982003658 Walker B motif; other site 336982003659 inhibitor binding site; inhibition site 336982003660 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 336982003661 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 336982003662 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 336982003663 gamma subunit interface [polypeptide binding]; other site 336982003664 epsilon subunit interface [polypeptide binding]; other site 336982003665 LBP interface [polypeptide binding]; other site 336982003666 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 336982003667 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 336982003668 Transposase; Region: DDE_Tnp_ISL3; pfam01610 336982003669 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 336982003670 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 336982003671 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 336982003672 hinge; other site 336982003673 active site 336982003674 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 336982003675 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 336982003676 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 336982003677 DNA binding site [nucleotide binding] 336982003678 active site 336982003679 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 336982003680 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 336982003681 AlkA N-terminal domain; Region: AlkA_N; pfam06029 336982003682 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 336982003683 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 336982003684 minor groove reading motif; other site 336982003685 helix-hairpin-helix signature motif; other site 336982003686 substrate binding pocket [chemical binding]; other site 336982003687 active site 336982003688 HAMP domain; Region: HAMP; pfam00672 336982003689 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 336982003690 cyclase homology domain; Region: CHD; cd07302 336982003691 nucleotidyl binding site; other site 336982003692 metal binding site [ion binding]; metal-binding site 336982003693 dimer interface [polypeptide binding]; other site 336982003694 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 336982003695 cyclase homology domain; Region: CHD; cd07302 336982003696 nucleotidyl binding site; other site 336982003697 metal binding site [ion binding]; metal-binding site 336982003698 dimer interface [polypeptide binding]; other site 336982003699 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 336982003700 Transposase; Region: HTH_Tnp_1; cl17663 336982003701 putative transposase OrfB; Reviewed; Region: PHA02517 336982003702 HTH-like domain; Region: HTH_21; pfam13276 336982003703 Integrase core domain; Region: rve; pfam00665 336982003704 Integrase core domain; Region: rve_3; pfam13683 336982003705 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 336982003706 dimerization interface [polypeptide binding]; other site 336982003707 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 336982003708 dimerization interface [polypeptide binding]; other site 336982003709 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 336982003710 cyclase homology domain; Region: CHD; cd07302 336982003711 nucleotidyl binding site; other site 336982003712 metal binding site [ion binding]; metal-binding site 336982003713 dimer interface [polypeptide binding]; other site 336982003714 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 336982003715 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 336982003716 dimerization interface [polypeptide binding]; other site 336982003717 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 336982003718 cyclase homology domain; Region: CHD; cd07302 336982003719 nucleotidyl binding site; other site 336982003720 metal binding site [ion binding]; metal-binding site 336982003721 dimer interface [polypeptide binding]; other site 336982003722 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 336982003723 hypothetical protein; Provisional; Region: PRK03298 336982003724 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 336982003725 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 336982003726 dimer interface [polypeptide binding]; other site 336982003727 substrate binding site [chemical binding]; other site 336982003728 metal binding site [ion binding]; metal-binding site 336982003729 putative acyltransferase; Provisional; Region: PRK05790 336982003730 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 336982003731 dimer interface [polypeptide binding]; other site 336982003732 active site 336982003733 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 336982003734 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 336982003735 PE family; Region: PE; pfam00934 336982003736 glycogen branching enzyme; Provisional; Region: PRK05402 336982003737 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 336982003738 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 336982003739 active site 336982003740 catalytic site [active] 336982003741 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 336982003742 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 336982003743 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 336982003744 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 336982003745 active site 336982003746 homodimer interface [polypeptide binding]; other site 336982003747 catalytic site [active] 336982003748 acceptor binding site [chemical binding]; other site 336982003749 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 336982003750 putative homodimer interface [polypeptide binding]; other site 336982003751 putative active site pocket [active] 336982003752 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 336982003753 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 336982003754 DEAD/DEAH box helicase; Region: DEAD; pfam00270 336982003755 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 336982003756 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 336982003757 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 336982003758 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 336982003759 active site 336982003760 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 336982003761 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 336982003762 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 336982003763 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 336982003764 putative active site pocket [active] 336982003765 cleavage site 336982003766 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 336982003767 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 336982003768 Rhomboid family; Region: Rhomboid; pfam01694 336982003769 glutamate racemase; Provisional; Region: PRK00865 336982003770 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 336982003771 ribonuclease PH; Reviewed; Region: rph; PRK00173 336982003772 Ribonuclease PH; Region: RNase_PH_bact; cd11362 336982003773 hexamer interface [polypeptide binding]; other site 336982003774 active site 336982003775 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 336982003776 active site 336982003777 dimerization interface [polypeptide binding]; other site 336982003778 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 336982003779 Glucitol operon activator [Transcription]; Region: GutM; COG4578 336982003780 acyl carrier protein; Validated; Region: PRK05883 336982003781 long-chain-fatty-acid--[acyl-carrier-protein] ligase; Validated; Region: PRK05851 336982003782 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 336982003783 acyl-activating enzyme (AAE) consensus motif; other site 336982003784 active site 336982003785 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 336982003786 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 336982003787 active site 336982003788 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 336982003789 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 336982003790 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 336982003791 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 336982003792 FAD binding pocket [chemical binding]; other site 336982003793 FAD binding motif [chemical binding]; other site 336982003794 phosphate binding motif [ion binding]; other site 336982003795 NAD binding pocket [chemical binding]; other site 336982003796 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 336982003797 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 336982003798 Walker A/P-loop; other site 336982003799 ATP binding site [chemical binding]; other site 336982003800 Q-loop/lid; other site 336982003801 ABC transporter signature motif; other site 336982003802 Walker B; other site 336982003803 D-loop; other site 336982003804 H-loop/switch region; other site 336982003805 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 336982003806 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 336982003807 Walker A/P-loop; other site 336982003808 ATP binding site [chemical binding]; other site 336982003809 Q-loop/lid; other site 336982003810 ABC transporter signature motif; other site 336982003811 Walker B; other site 336982003812 D-loop; other site 336982003813 H-loop/switch region; other site 336982003814 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 336982003815 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982003816 NAD(P) binding site [chemical binding]; other site 336982003817 active site 336982003818 tetracycline repressor protein TetR; Provisional; Region: PRK13756 336982003819 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982003820 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 336982003821 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 336982003822 GAF domain; Region: GAF; pfam01590 336982003823 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 336982003824 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 336982003825 metal binding site [ion binding]; metal-binding site 336982003826 active site 336982003827 I-site; other site 336982003828 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 336982003829 hypothetical protein; Provisional; Region: PRK07877 336982003830 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 336982003831 ATP binding site [chemical binding]; other site 336982003832 substrate interface [chemical binding]; other site 336982003833 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 336982003834 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 336982003835 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 336982003836 cyclase homology domain; Region: CHD; cd07302 336982003837 nucleotidyl binding site; other site 336982003838 dimer interface [polypeptide binding]; other site 336982003839 metal binding site [ion binding]; metal-binding site 336982003840 Predicted ATPase [General function prediction only]; Region: COG3903 336982003841 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 336982003842 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 336982003843 DNA binding residues [nucleotide binding] 336982003844 dimerization interface [polypeptide binding]; other site 336982003845 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 336982003846 cyclase homology domain; Region: CHD; cd07302 336982003847 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 336982003848 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 336982003849 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982003850 PPE family; Region: PPE; pfam00823 336982003851 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 336982003852 PAS fold; Region: PAS_4; pfam08448 336982003853 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 336982003854 putative active site [active] 336982003855 heme pocket [chemical binding]; other site 336982003856 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 336982003857 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 336982003858 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 336982003859 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 336982003860 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 336982003861 anti sigma factor interaction site; other site 336982003862 regulatory phosphorylation site [posttranslational modification]; other site 336982003863 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 336982003864 anti sigma factor interaction site; other site 336982003865 regulatory phosphorylation site [posttranslational modification]; other site 336982003866 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 336982003867 synthetase active site [active] 336982003868 NTP binding site [chemical binding]; other site 336982003869 metal binding site [ion binding]; metal-binding site 336982003870 Beta-lactamase; Region: Beta-lactamase; pfam00144 336982003871 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 336982003872 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 336982003873 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; pfam00173 336982003874 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 336982003875 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 336982003876 putative di-iron ligands [ion binding]; other site 336982003877 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 336982003878 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 336982003879 malonyl-CoA binding site [chemical binding]; other site 336982003880 dimer interface [polypeptide binding]; other site 336982003881 active site 336982003882 product binding site; other site 336982003883 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 336982003884 uncharacterized domain; Region: TIGR00702 336982003885 YcaO-like family; Region: YcaO; pfam02624 336982003886 Uncharacterized conserved protein [Function unknown]; Region: COG3482 336982003887 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 336982003888 S-adenosylmethionine binding site [chemical binding]; other site 336982003889 Domain of unknown function (DUF222); Region: DUF222; pfam02720 336982003890 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 336982003891 active site 336982003892 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 336982003893 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 336982003894 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 336982003895 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 336982003896 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 336982003897 dihydroorotase; Validated; Region: pyrC; PRK09357 336982003898 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 336982003899 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 336982003900 active site 336982003901 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 336982003902 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 336982003903 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 336982003904 catalytic site [active] 336982003905 subunit interface [polypeptide binding]; other site 336982003906 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 336982003907 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 336982003908 ATP-grasp domain; Region: ATP-grasp_4; cl17255 336982003909 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 336982003910 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 336982003911 ATP-grasp domain; Region: ATP-grasp_4; cl17255 336982003912 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 336982003913 IMP binding site; other site 336982003914 dimer interface [polypeptide binding]; other site 336982003915 interdomain contacts; other site 336982003916 partial ornithine binding site; other site 336982003917 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 336982003918 active site 336982003919 dimer interface [polypeptide binding]; other site 336982003920 PE family; Region: PE; pfam00934 336982003921 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982003922 PPE family; Region: PPE; pfam00823 336982003923 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 336982003924 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 336982003925 catalytic site [active] 336982003926 G-X2-G-X-G-K; other site 336982003927 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 336982003928 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 336982003929 Flavoprotein; Region: Flavoprotein; pfam02441 336982003930 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 336982003931 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 336982003932 S-adenosylmethionine synthetase; Validated; Region: PRK05250 336982003933 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 336982003934 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 336982003935 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 336982003936 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 336982003937 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 336982003938 Cytochrome P450; Region: p450; cl12078 336982003939 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 336982003940 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 336982003941 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 336982003942 PE family; Region: PE; pfam00934 336982003943 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 336982003944 oligomeric interface; other site 336982003945 putative active site [active] 336982003946 homodimer interface [polypeptide binding]; other site 336982003947 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 336982003948 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 336982003949 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 336982003950 substrate binding pocket [chemical binding]; other site 336982003951 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 336982003952 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 336982003953 substrate binding pocket [chemical binding]; other site 336982003954 Predicted membrane protein [Function unknown]; Region: COG3714 336982003955 primosome assembly protein PriA; Provisional; Region: PRK14873 336982003956 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 336982003957 S-adenosylmethionine binding site [chemical binding]; other site 336982003958 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 336982003959 MarR family; Region: MarR; pfam01047 336982003960 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 336982003961 S-adenosylmethionine binding site [chemical binding]; other site 336982003962 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 336982003963 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 336982003964 putative active site [active] 336982003965 substrate binding site [chemical binding]; other site 336982003966 putative cosubstrate binding site; other site 336982003967 catalytic site [active] 336982003968 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 336982003969 substrate binding site [chemical binding]; other site 336982003970 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 336982003971 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 336982003972 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 336982003973 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 336982003974 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 336982003975 substrate binding site [chemical binding]; other site 336982003976 hexamer interface [polypeptide binding]; other site 336982003977 metal binding site [ion binding]; metal-binding site 336982003978 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 336982003979 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 336982003980 catalytic motif [active] 336982003981 Zn binding site [ion binding]; other site 336982003982 RibD C-terminal domain; Region: RibD_C; pfam01872 336982003983 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 336982003984 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 336982003985 putative substrate translocation pore; other site 336982003986 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 336982003987 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 336982003988 Lumazine binding domain; Region: Lum_binding; pfam00677 336982003989 Lumazine binding domain; Region: Lum_binding; pfam00677 336982003990 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 336982003991 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 336982003992 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 336982003993 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 336982003994 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 336982003995 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 336982003996 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 336982003997 dimerization interface [polypeptide binding]; other site 336982003998 active site 336982003999 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 336982004000 homopentamer interface [polypeptide binding]; other site 336982004001 active site 336982004002 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 336982004003 PknH-like extracellular domain; Region: PknH_C; pfam14032 336982004004 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 336982004005 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 336982004006 putative sugar binding sites [chemical binding]; other site 336982004007 Q-X-W motif; other site 336982004008 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 336982004009 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 336982004010 GIY-YIG motif/motif A; other site 336982004011 active site 336982004012 catalytic site [active] 336982004013 putative DNA binding site [nucleotide binding]; other site 336982004014 metal binding site [ion binding]; metal-binding site 336982004015 UvrB/uvrC motif; Region: UVR; pfam02151 336982004016 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 336982004017 Helix-hairpin-helix motif; Region: HHH; pfam00633 336982004018 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 336982004019 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 336982004020 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 336982004021 phosphate binding site [ion binding]; other site 336982004022 putative substrate binding pocket [chemical binding]; other site 336982004023 dimer interface [polypeptide binding]; other site 336982004024 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 336982004025 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 336982004026 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 336982004027 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 336982004028 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 336982004029 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 336982004030 acyl-CoA synthetase; Provisional; Region: PRK13382 336982004031 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 336982004032 acyl-activating enzyme (AAE) consensus motif; other site 336982004033 putative AMP binding site [chemical binding]; other site 336982004034 putative active site [active] 336982004035 putative CoA binding site [chemical binding]; other site 336982004036 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 336982004037 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 336982004038 putative acyl-acceptor binding pocket; other site 336982004039 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 336982004040 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 336982004041 PE family; Region: PE; pfam00934 336982004042 PE-PPE domain; Region: PE-PPE; pfam08237 336982004043 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 336982004044 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 336982004045 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 336982004046 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 336982004047 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 336982004048 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 336982004049 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 336982004050 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 336982004051 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 336982004052 Phosphoglycerate kinase; Region: PGK; pfam00162 336982004053 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 336982004054 substrate binding site [chemical binding]; other site 336982004055 hinge regions; other site 336982004056 ADP binding site [chemical binding]; other site 336982004057 catalytic site [active] 336982004058 triosephosphate isomerase; Provisional; Region: PRK14567 336982004059 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 336982004060 substrate binding site [chemical binding]; other site 336982004061 dimer interface [polypeptide binding]; other site 336982004062 catalytic triad [active] 336982004063 SnoaL-like domain; Region: SnoaL_2; pfam12680 336982004064 Preprotein translocase SecG subunit; Region: SecG; cl09123 336982004065 PE family; Region: PE; pfam00934 336982004066 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 336982004067 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 336982004068 molybdopterin cofactor binding site [chemical binding]; other site 336982004069 substrate binding site [chemical binding]; other site 336982004070 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 336982004071 molybdopterin cofactor binding site; other site 336982004072 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 336982004073 hydrophobic ligand binding site; other site 336982004074 Proteins of 100 residues with WXG; Region: WXG100; cl02005 336982004075 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 336982004076 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 336982004077 putative active site [active] 336982004078 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 336982004079 Glucose-6-P dehydrogenase subunit [Carbohydrate transport and metabolism]; Region: COG3429 336982004080 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 336982004081 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 336982004082 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 336982004083 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 336982004084 putative active site [active] 336982004085 transaldolase; Provisional; Region: PRK03903 336982004086 catalytic residue [active] 336982004087 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 336982004088 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 336982004089 TPP-binding site [chemical binding]; other site 336982004090 dimer interface [polypeptide binding]; other site 336982004091 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 336982004092 PYR/PP interface [polypeptide binding]; other site 336982004093 dimer interface [polypeptide binding]; other site 336982004094 TPP binding site [chemical binding]; other site 336982004095 PE family; Region: PE; pfam00934 336982004096 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 336982004097 UbiA prenyltransferase family; Region: UbiA; pfam01040 336982004098 PE family; Region: PE; pfam00934 336982004099 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 336982004100 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 336982004101 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 336982004102 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 336982004103 NADP binding site [chemical binding]; other site 336982004104 dimer interface [polypeptide binding]; other site 336982004105 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 336982004106 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 336982004107 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 336982004108 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 336982004109 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 336982004110 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 336982004111 Walker A/P-loop; other site 336982004112 ATP binding site [chemical binding]; other site 336982004113 Q-loop/lid; other site 336982004114 ABC transporter signature motif; other site 336982004115 Walker B; other site 336982004116 D-loop; other site 336982004117 H-loop/switch region; other site 336982004118 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 336982004119 Predicted transcriptional regulator [Transcription]; Region: COG2345 336982004120 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 336982004121 putative DNA binding site [nucleotide binding]; other site 336982004122 putative Zn2+ binding site [ion binding]; other site 336982004123 Transcriptional regulator PadR-like family; Region: PadR; cl17335 336982004124 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 336982004125 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 336982004126 protein-splicing catalytic site; other site 336982004127 thioester formation/cholesterol transfer; other site 336982004128 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 336982004129 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 336982004130 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 336982004131 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 336982004132 FeS assembly protein SufD; Region: sufD; TIGR01981 336982004133 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 336982004134 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 336982004135 Walker A/P-loop; other site 336982004136 ATP binding site [chemical binding]; other site 336982004137 Q-loop/lid; other site 336982004138 ABC transporter signature motif; other site 336982004139 Walker B; other site 336982004140 D-loop; other site 336982004141 H-loop/switch region; other site 336982004142 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 336982004143 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 336982004144 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 336982004145 catalytic residue [active] 336982004146 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 336982004147 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 336982004148 trimerization site [polypeptide binding]; other site 336982004149 active site 336982004150 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 336982004151 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 336982004152 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 336982004153 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 336982004154 active site 336982004155 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 336982004156 PE family; Region: PE; pfam00934 336982004157 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 336982004158 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 336982004159 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 336982004160 catalytic residues [active] 336982004161 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 336982004162 catalytic residues [active] 336982004163 enoyl-CoA hydratase; Provisional; Region: PRK05864 336982004164 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 336982004165 substrate binding site [chemical binding]; other site 336982004166 oxyanion hole (OAH) forming residues; other site 336982004167 trimer interface [polypeptide binding]; other site 336982004168 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 336982004169 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 336982004170 Walker A/P-loop; other site 336982004171 ATP binding site [chemical binding]; other site 336982004172 Q-loop/lid; other site 336982004173 ABC transporter signature motif; other site 336982004174 Walker B; other site 336982004175 D-loop; other site 336982004176 H-loop/switch region; other site 336982004177 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 336982004178 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982004179 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982004180 aconitate hydratase; Validated; Region: PRK09277 336982004181 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 336982004182 substrate binding site [chemical binding]; other site 336982004183 ligand binding site [chemical binding]; other site 336982004184 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 336982004185 substrate binding site [chemical binding]; other site 336982004186 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 336982004187 NlpC/P60 family; Region: NLPC_P60; pfam00877 336982004188 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 336982004189 NlpC/P60 family; Region: NLPC_P60; pfam00877 336982004190 MoxR-like ATPases [General function prediction only]; Region: COG0714 336982004191 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 336982004192 Walker A motif; other site 336982004193 ATP binding site [chemical binding]; other site 336982004194 Walker B motif; other site 336982004195 arginine finger; other site 336982004196 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 336982004197 Protein of unknown function DUF58; Region: DUF58; pfam01882 336982004198 hypothetical protein; Provisional; Region: PRK13685 336982004199 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 336982004200 metal ion-dependent adhesion site (MIDAS); other site 336982004201 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 336982004202 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 336982004203 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 336982004204 NAD(P) binding site [chemical binding]; other site 336982004205 homotetramer interface [polypeptide binding]; other site 336982004206 homodimer interface [polypeptide binding]; other site 336982004207 active site 336982004208 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 336982004209 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 336982004210 NAD binding site [chemical binding]; other site 336982004211 homotetramer interface [polypeptide binding]; other site 336982004212 homodimer interface [polypeptide binding]; other site 336982004213 substrate binding site [chemical binding]; other site 336982004214 active site 336982004215 ferrochelatase; Reviewed; Region: hemH; PRK00035 336982004216 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 336982004217 C-terminal domain interface [polypeptide binding]; other site 336982004218 active site 336982004219 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 336982004220 active site 336982004221 N-terminal domain interface [polypeptide binding]; other site 336982004222 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 336982004223 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 336982004224 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 336982004225 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 336982004226 Uncharacterized conserved protein [Function unknown]; Region: COG0398 336982004227 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 336982004228 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 336982004229 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 336982004230 heterodimer interface [polypeptide binding]; other site 336982004231 substrate interaction site [chemical binding]; other site 336982004232 Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding) [Lipid metabolism]; Region: Sbm; COG2185 336982004233 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 336982004234 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 336982004235 active site 336982004236 substrate binding site [chemical binding]; other site 336982004237 coenzyme B12 binding site [chemical binding]; other site 336982004238 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 336982004239 B12 binding site [chemical binding]; other site 336982004240 cobalt ligand [ion binding]; other site 336982004241 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 336982004242 membrane ATPase/protein kinase; Provisional; Region: PRK09435 336982004243 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 336982004244 Walker A; other site 336982004245 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 336982004246 Beta-lactamase; Region: Beta-lactamase; pfam00144 336982004247 Methyltransferase domain; Region: Methyltransf_31; pfam13847 336982004248 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 336982004249 S-adenosylmethionine binding site [chemical binding]; other site 336982004250 Uncharacterized conserved protein [Function unknown]; Region: COG3360 336982004251 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 336982004252 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 336982004253 Ligand binding site; other site 336982004254 Putative Catalytic site; other site 336982004255 DXD motif; other site 336982004256 Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5285 336982004257 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 336982004258 active site 336982004259 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 336982004260 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 336982004261 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 336982004262 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 336982004263 inhibitor-cofactor binding pocket; inhibition site 336982004264 pyridoxal 5'-phosphate binding site [chemical binding]; other site 336982004265 catalytic residue [active] 336982004266 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 336982004267 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 336982004268 putative trimer interface [polypeptide binding]; other site 336982004269 putative CoA binding site [chemical binding]; other site 336982004270 Methyltransferase domain; Region: Methyltransf_12; pfam08242 336982004271 S-adenosylmethionine binding site [chemical binding]; other site 336982004272 WbqC-like protein family; Region: WbqC; pfam08889 336982004273 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 336982004274 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982004275 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982004276 Methyltransferase domain; Region: Methyltransf_23; pfam13489 336982004277 Methyltransferase domain; Region: Methyltransf_12; pfam08242 336982004278 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 336982004279 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 336982004280 NADP-binding site; other site 336982004281 homotetramer interface [polypeptide binding]; other site 336982004282 substrate binding site [chemical binding]; other site 336982004283 homodimer interface [polypeptide binding]; other site 336982004284 active site 336982004285 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 336982004286 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 336982004287 NADP binding site [chemical binding]; other site 336982004288 active site 336982004289 putative substrate binding site [chemical binding]; other site 336982004290 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 336982004291 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 336982004292 metal-binding site 336982004293 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 336982004294 S-adenosylmethionine binding site [chemical binding]; other site 336982004295 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 336982004296 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 336982004297 active site 336982004298 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 336982004299 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 336982004300 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 336982004301 active site 336982004302 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 336982004303 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 336982004304 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 336982004305 active site 336982004306 acyl-CoA synthetase; Validated; Region: PRK05850 336982004307 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 336982004308 acyl-activating enzyme (AAE) consensus motif; other site 336982004309 active site 336982004310 Transport protein; Region: actII; TIGR00833 336982004311 Methyltransferase domain; Region: Methyltransf_23; pfam13489 336982004312 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 336982004313 S-adenosylmethionine binding site [chemical binding]; other site 336982004314 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 336982004315 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 336982004316 homodimer interface [polypeptide binding]; other site 336982004317 active site 336982004318 TDP-binding site; other site 336982004319 acceptor substrate-binding pocket; other site 336982004320 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 336982004321 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 336982004322 Probable Catalytic site; other site 336982004323 metal-binding site 336982004324 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 336982004325 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 336982004326 homodimer interface [polypeptide binding]; other site 336982004327 active site 336982004328 TDP-binding site; other site 336982004329 acceptor substrate-binding pocket; other site 336982004330 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 336982004331 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 336982004332 active site 336982004333 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 336982004334 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 336982004335 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982004336 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 336982004337 Enoylreductase; Region: PKS_ER; smart00829 336982004338 NAD(P) binding site [chemical binding]; other site 336982004339 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 336982004340 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 336982004341 putative NADP binding site [chemical binding]; other site 336982004342 active site 336982004343 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 336982004344 acyl-CoA synthetase; Validated; Region: PRK05850 336982004345 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 336982004346 acyl-activating enzyme (AAE) consensus motif; other site 336982004347 active site 336982004348 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 336982004349 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 336982004350 NAD(P) binding site [chemical binding]; other site 336982004351 Uncharacterized conserved protein [Function unknown]; Region: COG2128 336982004352 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 336982004353 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 336982004354 CoenzymeA binding site [chemical binding]; other site 336982004355 subunit interaction site [polypeptide binding]; other site 336982004356 PHB binding site; other site 336982004357 Nitronate monooxygenase; Region: NMO; pfam03060 336982004358 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 336982004359 FMN binding site [chemical binding]; other site 336982004360 substrate binding site [chemical binding]; other site 336982004361 putative catalytic residue [active] 336982004362 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982004363 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 336982004364 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 336982004365 HIGH motif; other site 336982004366 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 336982004367 active site 336982004368 KMSKS motif; other site 336982004369 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 336982004370 tRNA binding surface [nucleotide binding]; other site 336982004371 anticodon binding site; other site 336982004372 DNA polymerase IV; Provisional; Region: PRK03348 336982004373 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 336982004374 active site 336982004375 DNA binding site [nucleotide binding] 336982004376 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 336982004377 active site 336982004378 homodimer interface [polypeptide binding]; other site 336982004379 homotetramer interface [polypeptide binding]; other site 336982004380 lipoprotein signal peptidase; Provisional; Region: PRK14764 336982004381 lipoprotein signal peptidase; Provisional; Region: PRK14787 336982004382 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 336982004383 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 336982004384 active site 336982004385 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 336982004386 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 336982004387 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 336982004388 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 336982004389 apolar tunnel; other site 336982004390 heme binding site [chemical binding]; other site 336982004391 dimerization interface [polypeptide binding]; other site 336982004392 short chain dehydrogenase; Provisional; Region: PRK05866 336982004393 classical (c) SDRs; Region: SDR_c; cd05233 336982004394 NAD(P) binding site [chemical binding]; other site 336982004395 active site 336982004396 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 336982004397 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982004398 NAD(P) binding site [chemical binding]; other site 336982004399 active site 336982004400 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 336982004401 hydrophobic ligand binding site; other site 336982004402 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 336982004403 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 336982004404 active site 336982004405 PHP Thumb interface [polypeptide binding]; other site 336982004406 metal binding site [ion binding]; metal-binding site 336982004407 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 336982004408 generic binding surface II; other site 336982004409 generic binding surface I; other site 336982004410 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982004411 PPE family; Region: PPE; pfam00823 336982004412 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982004413 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982004414 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 336982004415 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 336982004416 acyl-activating enzyme (AAE) consensus motif; other site 336982004417 putative AMP binding site [chemical binding]; other site 336982004418 putative active site [active] 336982004419 putative CoA binding site [chemical binding]; other site 336982004420 glycerol-3-phosphate acyltransferase; Reviewed; Region: PRK11915 336982004421 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 336982004422 putative acyl-acceptor binding pocket; other site 336982004423 fumarate reductase, flavoprotein subunit; Region: fum_red_Fp; TIGR01176 336982004424 L-aspartate oxidase; Provisional; Region: PRK06175 336982004425 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 336982004426 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 336982004427 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 336982004428 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 336982004429 D-subunit interface [polypeptide binding]; other site 336982004430 Iron-sulfur protein interface; other site 336982004431 proximal quinone binding site [chemical binding]; other site 336982004432 distal quinone binding site [chemical binding]; other site 336982004433 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 336982004434 Iron-sulfur protein interface; other site 336982004435 proximal quinone binding site [chemical binding]; other site 336982004436 C-subunit interface; other site 336982004437 distal quinone binding site; other site 336982004438 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982004439 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982004440 MMPL family; Region: MMPL; pfam03176 336982004441 Domain of unknown function (DUF385); Region: DUF385; pfam04075 336982004442 threonine dehydratase; Validated; Region: PRK08639 336982004443 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 336982004444 tetramer interface [polypeptide binding]; other site 336982004445 pyridoxal 5'-phosphate binding site [chemical binding]; other site 336982004446 catalytic residue [active] 336982004447 C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585 336982004448 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 336982004449 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 336982004450 putative active site [active] 336982004451 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 336982004452 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 336982004453 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 336982004454 catalytic site [active] 336982004455 active site 336982004456 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 336982004457 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 336982004458 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 336982004459 active site 336982004460 catalytic site [active] 336982004461 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 336982004462 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 336982004463 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 336982004464 active site 336982004465 catalytic site [active] 336982004466 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 336982004467 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 336982004468 NlpC/P60 family; Region: NLPC_P60; pfam00877 336982004469 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 336982004470 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 336982004471 inhibitor-cofactor binding pocket; inhibition site 336982004472 pyridoxal 5'-phosphate binding site [chemical binding]; other site 336982004473 catalytic residue [active] 336982004474 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 336982004475 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 336982004476 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 336982004477 catalytic residue [active] 336982004478 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 336982004479 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 336982004480 Domain of unknown function (DUF222); Region: DUF222; pfam02720 336982004481 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 336982004482 active site 336982004483 Domain of unknown function (DUF222); Region: DUF222; pfam02720 336982004484 biotin synthase; Validated; Region: PRK06256 336982004485 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 336982004486 FeS/SAM binding site; other site 336982004487 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 336982004488 Protein of unknown function (DUF2567); Region: DUF2567; pfam10821 336982004489 Secretory lipase; Region: LIP; pfam03583 336982004490 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 336982004491 nudix motif; other site 336982004492 quinolinate synthetase; Provisional; Region: PRK09375 336982004493 L-aspartate oxidase; Provisional; Region: PRK07804 336982004494 L-aspartate oxidase; Provisional; Region: PRK06175 336982004495 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 336982004496 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 336982004497 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 336982004498 dimerization interface [polypeptide binding]; other site 336982004499 active site 336982004500 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 336982004501 S-adenosylmethionine binding site [chemical binding]; other site 336982004502 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 336982004503 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 336982004504 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 336982004505 NAD binding site [chemical binding]; other site 336982004506 dimerization interface [polypeptide binding]; other site 336982004507 product binding site; other site 336982004508 substrate binding site [chemical binding]; other site 336982004509 zinc binding site [ion binding]; other site 336982004510 catalytic residues [active] 336982004511 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 336982004512 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 336982004513 pyridoxal 5'-phosphate binding site [chemical binding]; other site 336982004514 homodimer interface [polypeptide binding]; other site 336982004515 catalytic residue [active] 336982004516 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 336982004517 4-fold oligomerization interface [polypeptide binding]; other site 336982004518 putative active site pocket [active] 336982004519 metal binding residues [ion binding]; metal-binding site 336982004520 3-fold/trimer interface [polypeptide binding]; other site 336982004521 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 336982004522 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 336982004523 putative active site [active] 336982004524 oxyanion strand; other site 336982004525 catalytic triad [active] 336982004526 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 336982004527 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 336982004528 catalytic residues [active] 336982004529 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 336982004530 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 336982004531 active site 336982004532 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 336982004533 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 336982004534 substrate binding site [chemical binding]; other site 336982004535 glutamase interaction surface [polypeptide binding]; other site 336982004536 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 336982004537 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 336982004538 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 336982004539 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 336982004540 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 336982004541 catalytic triad [active] 336982004542 anthranilate synthase component I; Provisional; Region: PRK13571 336982004543 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 336982004544 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 336982004545 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 336982004546 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 336982004547 active site 336982004548 ribulose/triose binding site [chemical binding]; other site 336982004549 phosphate binding site [ion binding]; other site 336982004550 substrate (anthranilate) binding pocket [chemical binding]; other site 336982004551 product (indole) binding pocket [chemical binding]; other site 336982004552 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 336982004553 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 336982004554 pyridoxal 5'-phosphate binding site [chemical binding]; other site 336982004555 catalytic residue [active] 336982004556 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 336982004557 substrate binding site [chemical binding]; other site 336982004558 active site 336982004559 catalytic residues [active] 336982004560 heterodimer interface [polypeptide binding]; other site 336982004561 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108 336982004562 Prolipoprotein diacylglyceryltransferase [Cell envelope biogenesis, outer membrane]; Region: Lgt; COG0682 336982004563 TM2 domain; Region: TM2; pfam05154 336982004564 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 336982004565 pyruvate kinase; Provisional; Region: PRK06247 336982004566 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 336982004567 domain interfaces; other site 336982004568 active site 336982004569 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 336982004570 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 336982004571 active site 336982004572 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 336982004573 catalytic triad [active] 336982004574 dimer interface [polypeptide binding]; other site 336982004575 Uncharacterized conserved protein [Function unknown]; Region: COG2898 336982004576 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 336982004577 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 336982004578 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 336982004579 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 336982004580 Walker A/P-loop; other site 336982004581 Walker A/P-loop; other site 336982004582 ATP binding site [chemical binding]; other site 336982004583 ATP binding site [chemical binding]; other site 336982004584 Q-loop/lid; other site 336982004585 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 336982004586 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 336982004587 Walker A/P-loop; other site 336982004588 ATP binding site [chemical binding]; other site 336982004589 Q-loop/lid; other site 336982004590 ABC transporter signature motif; other site 336982004591 Walker B; other site 336982004592 D-loop; other site 336982004593 H-loop/switch region; other site 336982004594 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 336982004595 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 336982004596 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 336982004597 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 336982004598 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 336982004599 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 336982004600 cyclase homology domain; Region: CHD; cd07302 336982004601 nucleotidyl binding site; other site 336982004602 metal binding site [ion binding]; metal-binding site 336982004603 dimer interface [polypeptide binding]; other site 336982004604 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 336982004605 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 336982004606 active site 336982004607 phosphorylation site [posttranslational modification] 336982004608 intermolecular recognition site; other site 336982004609 dimerization interface [polypeptide binding]; other site 336982004610 ANTAR domain; Region: ANTAR; pfam03861 336982004611 lipid-transfer protein; Provisional; Region: PRK06059 336982004612 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 336982004613 active site 336982004614 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 336982004615 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 336982004616 DUF35 OB-fold domain; Region: DUF35; pfam01796 336982004617 DNA polymerase I; Provisional; Region: PRK05755 336982004618 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 336982004619 active site 336982004620 metal binding site 1 [ion binding]; metal-binding site 336982004621 putative 5' ssDNA interaction site; other site 336982004622 metal binding site 3; metal-binding site 336982004623 metal binding site 2 [ion binding]; metal-binding site 336982004624 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 336982004625 putative DNA binding site [nucleotide binding]; other site 336982004626 putative metal binding site [ion binding]; other site 336982004627 3'-5' exonuclease; Region: 35EXOc; smart00474 336982004628 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 336982004629 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 336982004630 active site 336982004631 DNA binding site [nucleotide binding] 336982004632 catalytic site [active] 336982004633 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 336982004634 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 336982004635 RNA binding site [nucleotide binding]; other site 336982004636 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 336982004637 RNA binding site [nucleotide binding]; other site 336982004638 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 336982004639 RNA binding site [nucleotide binding]; other site 336982004640 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 336982004641 RNA binding site [nucleotide binding]; other site 336982004642 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 336982004643 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 336982004644 CoA-binding site [chemical binding]; other site 336982004645 ATP-binding [chemical binding]; other site 336982004646 Uncharacterized conserved protein [Function unknown]; Region: GrpB; COG2320 336982004647 Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306 336982004648 excinuclease ABC subunit B; Provisional; Region: PRK05298 336982004649 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 336982004650 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 336982004651 nucleotide binding region [chemical binding]; other site 336982004652 ATP-binding site [chemical binding]; other site 336982004653 Ultra-violet resistance protein B; Region: UvrB; pfam12344 336982004654 UvrB/uvrC motif; Region: UVR; pfam02151 336982004655 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 336982004656 Major Facilitator Superfamily; Region: MFS_1; pfam07690 336982004657 putative substrate translocation pore; other site 336982004658 Predicted membrane protein [Function unknown]; Region: COG5305 336982004659 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 336982004660 Ligand Binding Site [chemical binding]; other site 336982004661 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 336982004662 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 336982004663 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 336982004664 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 336982004665 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 336982004666 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 336982004667 Predicted esterase [General function prediction only]; Region: COG0627 336982004668 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 336982004669 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 336982004670 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 336982004671 dimer interface [polypeptide binding]; other site 336982004672 putative anticodon binding site; other site 336982004673 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 336982004674 motif 1; other site 336982004675 dimer interface [polypeptide binding]; other site 336982004676 active site 336982004677 motif 2; other site 336982004678 motif 3; other site 336982004679 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 336982004680 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 336982004681 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 336982004682 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 336982004683 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 336982004684 23S rRNA binding site [nucleotide binding]; other site 336982004685 L21 binding site [polypeptide binding]; other site 336982004686 L13 binding site [polypeptide binding]; other site 336982004687 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 336982004688 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 336982004689 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 336982004690 PE family; Region: PE; pfam00934 336982004691 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 336982004692 cyclase homology domain; Region: CHD; cd07302 336982004693 nucleotidyl binding site; other site 336982004694 metal binding site [ion binding]; metal-binding site 336982004695 dimer interface [polypeptide binding]; other site 336982004696 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 336982004697 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 336982004698 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 336982004699 dimer interface [polypeptide binding]; other site 336982004700 motif 1; other site 336982004701 active site 336982004702 motif 2; other site 336982004703 motif 3; other site 336982004704 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 336982004705 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 336982004706 putative tRNA-binding site [nucleotide binding]; other site 336982004707 B3/4 domain; Region: B3_4; pfam03483 336982004708 tRNA synthetase B5 domain; Region: B5; smart00874 336982004709 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 336982004710 dimer interface [polypeptide binding]; other site 336982004711 motif 1; other site 336982004712 motif 3; other site 336982004713 motif 2; other site 336982004714 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 336982004715 PE family; Region: PE; pfam00934 336982004716 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 336982004717 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 336982004718 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 336982004719 heterotetramer interface [polypeptide binding]; other site 336982004720 active site pocket [active] 336982004721 cleavage site 336982004722 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 336982004723 feedback inhibition sensing region; other site 336982004724 homohexameric interface [polypeptide binding]; other site 336982004725 nucleotide binding site [chemical binding]; other site 336982004726 N-acetyl-L-glutamate binding site [chemical binding]; other site 336982004727 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 336982004728 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 336982004729 inhibitor-cofactor binding pocket; inhibition site 336982004730 pyridoxal 5'-phosphate binding site [chemical binding]; other site 336982004731 catalytic residue [active] 336982004732 ornithine carbamoyltransferase; Provisional; Region: PRK00779 336982004733 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 336982004734 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 336982004735 arginine repressor; Provisional; Region: PRK03341 336982004736 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 336982004737 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 336982004738 argininosuccinate synthase; Provisional; Region: PRK13820 336982004739 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 336982004740 ANP binding site [chemical binding]; other site 336982004741 Substrate Binding Site II [chemical binding]; other site 336982004742 Substrate Binding Site I [chemical binding]; other site 336982004743 argininosuccinate lyase; Provisional; Region: PRK00855 336982004744 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 336982004745 active sites [active] 336982004746 tetramer interface [polypeptide binding]; other site 336982004747 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 336982004748 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 336982004749 malonyl-CoA binding site [chemical binding]; other site 336982004750 dimer interface [polypeptide binding]; other site 336982004751 active site 336982004752 product binding site; other site 336982004753 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 336982004754 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 336982004755 active site 336982004756 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 336982004757 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 336982004758 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982004759 Enoylreductase; Region: PKS_ER; smart00829 336982004760 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 336982004761 NAD(P) binding site [chemical binding]; other site 336982004762 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 336982004763 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 336982004764 putative NADP binding site [chemical binding]; other site 336982004765 active site 336982004766 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 336982004767 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 336982004768 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 336982004769 active site 336982004770 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 336982004771 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 336982004772 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982004773 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 336982004774 Enoylreductase; Region: PKS_ER; smart00829 336982004775 NAD(P) binding site [chemical binding]; other site 336982004776 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 336982004777 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 336982004778 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 336982004779 putative NADP binding site [chemical binding]; other site 336982004780 active site 336982004781 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 336982004782 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 336982004783 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 336982004784 active site 336982004785 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 336982004786 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 336982004787 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 336982004788 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 336982004789 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 336982004790 malonyl-CoA binding site [chemical binding]; other site 336982004791 dimer interface [polypeptide binding]; other site 336982004792 active site 336982004793 product binding site; other site 336982004794 Cytochrome P450; Region: p450; cl12078 336982004795 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 336982004796 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 336982004797 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 336982004798 ABC transporter; Region: ABC_tran_2; pfam12848 336982004799 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 336982004800 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 336982004801 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 336982004802 putative substrate translocation pore; other site 336982004803 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 336982004804 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 336982004805 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 336982004806 dimerization interface [polypeptide binding]; other site 336982004807 putative DNA binding site [nucleotide binding]; other site 336982004808 putative Zn2+ binding site [ion binding]; other site 336982004809 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 336982004810 active site residue [active] 336982004811 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 336982004812 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 336982004813 ligand binding site [chemical binding]; other site 336982004814 flexible hinge region; other site 336982004815 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 336982004816 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 336982004817 putative catalytic residues [active] 336982004818 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 336982004819 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 336982004820 catalytic residues [active] 336982004821 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 336982004822 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 336982004823 active site 336982004824 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 336982004825 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 336982004826 substrate binding pocket [chemical binding]; other site 336982004827 membrane-bound complex binding site; other site 336982004828 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 336982004829 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 336982004830 FeS/SAM binding site; other site 336982004831 DivIVA protein; Region: DivIVA; pfam05103 336982004832 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 336982004833 acyl-CoA synthetase; Validated; Region: PRK07868 336982004834 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 336982004835 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 336982004836 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 336982004837 acyl-activating enzyme (AAE) consensus motif; other site 336982004838 AMP binding site [chemical binding]; other site 336982004839 active site 336982004840 CoA binding site [chemical binding]; other site 336982004841 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982004842 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982004843 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 336982004844 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 336982004845 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 336982004846 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 336982004847 Walker A/P-loop; other site 336982004848 ATP binding site [chemical binding]; other site 336982004849 Q-loop/lid; other site 336982004850 ABC transporter signature motif; other site 336982004851 Walker B; other site 336982004852 D-loop; other site 336982004853 H-loop/switch region; other site 336982004854 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 336982004855 active site 336982004856 DNA binding site [nucleotide binding] 336982004857 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 336982004858 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 336982004859 active site 336982004860 HIGH motif; other site 336982004861 dimer interface [polypeptide binding]; other site 336982004862 KMSKS motif; other site 336982004863 S4 RNA-binding domain; Region: S4; smart00363 336982004864 RNA binding surface [nucleotide binding]; other site 336982004865 Protein of unknown function (DUF732); Region: DUF732; pfam05305 336982004866 Tetratrico peptide repeat; Region: TPR_5; pfam12688 336982004867 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 336982004868 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 336982004869 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 336982004870 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 336982004871 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 336982004872 RNA binding surface [nucleotide binding]; other site 336982004873 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 336982004874 S-adenosylmethionine binding site [chemical binding]; other site 336982004875 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 336982004876 ATP-NAD kinase; Region: NAD_kinase; pfam01513 336982004877 DNA repair protein RecN; Region: recN; TIGR00634 336982004878 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 336982004879 Walker A/P-loop; other site 336982004880 ATP binding site [chemical binding]; other site 336982004881 Q-loop/lid; other site 336982004882 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 336982004883 ABC transporter signature motif; other site 336982004884 Walker B; other site 336982004885 D-loop; other site 336982004886 H-loop/switch region; other site 336982004887 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 336982004888 Thiamine pyrophosphokinase; Region: TPK; cl08415 336982004889 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 336982004890 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 336982004891 CTP synthetase; Validated; Region: pyrG; PRK05380 336982004892 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 336982004893 Catalytic site [active] 336982004894 active site 336982004895 UTP binding site [chemical binding]; other site 336982004896 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 336982004897 active site 336982004898 putative oxyanion hole; other site 336982004899 catalytic triad [active] 336982004900 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 336982004901 dimer interface [polypeptide binding]; other site 336982004902 ADP-ribose binding site [chemical binding]; other site 336982004903 active site 336982004904 nudix motif; other site 336982004905 metal binding site [ion binding]; metal-binding site 336982004906 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 336982004907 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 336982004908 active site 336982004909 DNA binding site [nucleotide binding] 336982004910 Int/Topo IB signature motif; other site 336982004911 Domain of unknown function (DUF222); Region: DUF222; pfam02720 336982004912 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 336982004913 active site 336982004914 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 336982004915 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 336982004916 S-adenosylmethionine binding site [chemical binding]; other site 336982004917 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 336982004918 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982004919 PPE family; Region: PPE; pfam00823 336982004920 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 336982004921 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982004922 PPE family; Region: PPE; pfam00823 336982004923 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 336982004924 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 336982004925 Sulfate transporter family; Region: Sulfate_transp; pfam00916 336982004926 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 336982004927 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 336982004928 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 336982004929 P-loop; other site 336982004930 Magnesium ion binding site [ion binding]; other site 336982004931 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 336982004932 Magnesium ion binding site [ion binding]; other site 336982004933 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 336982004934 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 336982004935 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 336982004936 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 336982004937 RNA binding surface [nucleotide binding]; other site 336982004938 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 336982004939 active site 336982004940 cytidylate kinase; Provisional; Region: cmk; PRK00023 336982004941 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 336982004942 CMP-binding site; other site 336982004943 The sites determining sugar specificity; other site 336982004944 GTP-binding protein Der; Reviewed; Region: PRK03003 336982004945 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 336982004946 GTP/Mg2+ binding site [chemical binding]; other site 336982004947 Switch I region; other site 336982004948 G2 box; other site 336982004949 Switch II region; other site 336982004950 G3 box; other site 336982004951 G4 box; other site 336982004952 G5 box; other site 336982004953 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 336982004954 G1 box; other site 336982004955 GTP/Mg2+ binding site [chemical binding]; other site 336982004956 Switch I region; other site 336982004957 G2 box; other site 336982004958 G3 box; other site 336982004959 Switch II region; other site 336982004960 G4 box; other site 336982004961 G5 box; other site 336982004962 short chain dehydrogenase; Provisional; Region: PRK07060 336982004963 classical (c) SDRs; Region: SDR_c; cd05233 336982004964 NAD(P) binding site [chemical binding]; other site 336982004965 active site 336982004966 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 336982004967 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 336982004968 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 336982004969 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 336982004970 Cupin domain; Region: Cupin_2; cl17218 336982004971 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 336982004972 Transcriptional regulator [Transcription]; Region: IclR; COG1414 336982004973 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 336982004974 putative switch regulator; other site 336982004975 non-specific DNA interactions [nucleotide binding]; other site 336982004976 DNA binding site [nucleotide binding] 336982004977 sequence specific DNA binding site [nucleotide binding]; other site 336982004978 putative cAMP binding site [chemical binding]; other site 336982004979 Bacterial transcriptional regulator; Region: IclR; pfam01614 336982004980 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 336982004981 putative active site [active] 336982004982 homotetrameric interface [polypeptide binding]; other site 336982004983 metal binding site [ion binding]; metal-binding site 336982004984 biotin carboxylase-like protein; Validated; Region: PRK06524 336982004985 ATP-grasp domain; Region: ATP-grasp_4; cl17255 336982004986 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 336982004987 Beta-lactamase; Region: Beta-lactamase; pfam00144 336982004988 hypothetical protein; Mapped to H37Rv Rv1724c; interrupted by transposases 336982004989 putative transposase OrfB; Reviewed; Region: PHA02517 336982004990 HTH-like domain; Region: HTH_21; pfam13276 336982004991 Integrase core domain; Region: rve; pfam00665 336982004992 Integrase core domain; Region: rve_3; pfam13683 336982004993 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 336982004994 Transposase; Region: HTH_Tnp_1; cl17663 336982004995 Predicted transcriptional regulators [Transcription]; Region: COG1733 336982004996 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 336982004997 dimerization interface [polypeptide binding]; other site 336982004998 putative DNA binding site [nucleotide binding]; other site 336982004999 putative Zn2+ binding site [ion binding]; other site 336982005000 Predicted transcriptional regulators [Transcription]; Region: COG1733 336982005001 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 336982005002 FAD binding domain; Region: FAD_binding_4; pfam01565 336982005003 Berberine and berberine like; Region: BBE; pfam08031 336982005004 TIGR03086 family protein; Region: TIGR03086 336982005005 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 336982005006 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 336982005007 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 336982005008 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 336982005009 Beta-lactamase; Region: Beta-lactamase; pfam00144 336982005010 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 336982005011 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 336982005012 NAD(P) binding site [chemical binding]; other site 336982005013 catalytic residues [active] 336982005014 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 336982005015 putative catalytic residue [active] 336982005016 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 336982005017 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 336982005018 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 336982005019 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 336982005020 gating phenylalanine in ion channel; other site 336982005021 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 336982005022 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 336982005023 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 336982005024 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 336982005025 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 336982005026 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 336982005027 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 336982005028 putative substrate translocation pore; other site 336982005029 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 336982005030 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 336982005031 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 336982005032 Sulfate transporter family; Region: Sulfate_transp; pfam00916 336982005033 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 336982005034 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 336982005035 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3742 336982005036 putative active site [active] 336982005037 Protein tyrosine kinase; Region: Pkinase_Tyr; pfam07714 336982005038 Catalytic domain of Protein Kinases; Region: PKc; cd00180 336982005039 active site 336982005040 ATP binding site [chemical binding]; other site 336982005041 substrate binding site [chemical binding]; other site 336982005042 activation loop (A-loop); other site 336982005043 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 336982005044 Thioredoxin; Region: Thioredoxin_4; cl17273 336982005045 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 336982005046 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 336982005047 active site 336982005048 metal binding site [ion binding]; metal-binding site 336982005049 nudix motif; other site 336982005050 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 336982005051 Catalytic domain of Protein Kinases; Region: PKc; cd00180 336982005052 active site 336982005053 ATP binding site [chemical binding]; other site 336982005054 substrate binding site [chemical binding]; other site 336982005055 activation loop (A-loop); other site 336982005056 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 336982005057 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 336982005058 phosphopeptide binding site; other site 336982005059 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 336982005060 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 336982005061 phosphopeptide binding site; other site 336982005062 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 336982005063 The Eye Pigment Precursor Transporter (EPP) Family protein; Region: 3a01204; TIGR00955 336982005064 Walker A/P-loop; other site 336982005065 ATP binding site [chemical binding]; other site 336982005066 Q-loop/lid; other site 336982005067 ABC transporter signature motif; other site 336982005068 Walker B; other site 336982005069 D-loop; other site 336982005070 H-loop/switch region; other site 336982005071 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 336982005072 acyl-CoA synthetase; Provisional; Region: PRK13388 336982005073 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 336982005074 acyl-activating enzyme (AAE) consensus motif; other site 336982005075 AMP binding site [chemical binding]; other site 336982005076 active site 336982005077 CoA binding site [chemical binding]; other site 336982005078 hypothetical protein; Provisional; Region: PRK06185 336982005079 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 336982005080 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 336982005081 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 336982005082 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982005083 PPE family; Region: PPE; pfam00823 336982005084 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982005085 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982005086 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 336982005087 putative transposase OrfB; Reviewed; Region: PHA02517 336982005088 HTH-like domain; Region: HTH_21; pfam13276 336982005089 Integrase core domain; Region: rve; pfam00665 336982005090 Integrase core domain; Region: rve_3; pfam13683 336982005091 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 336982005092 Transposase; Region: HTH_Tnp_1; cl17663 336982005093 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 336982005094 Phosphoesterase family; Region: Phosphoesterase; pfam04185 336982005095 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 336982005096 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 336982005097 sulfite oxidase; Provisional; Region: PLN00177 336982005098 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 336982005099 Moco binding site; other site 336982005100 metal coordination site [ion binding]; other site 336982005101 dimerization interface [polypeptide binding]; other site 336982005102 Transport protein; Region: actII; TIGR00833 336982005103 cutinase cut1; Mapped to H37Rv Rv1758; interrupted by transposases 336982005104 putative transposase OrfB; Reviewed; Region: PHA02517 336982005105 HTH-like domain; Region: HTH_21; pfam13276 336982005106 Integrase core domain; Region: rve; pfam00665 336982005107 Integrase core domain; Region: rve_3; pfam13683 336982005108 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 336982005109 Transposase; Region: HTH_Tnp_1; cl17663 336982005110 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 336982005111 Transposase; Region: HTH_Tnp_1; cl17663 336982005112 putative transposase OrfB; Reviewed; Region: PHA02517 336982005113 HTH-like domain; Region: HTH_21; pfam13276 336982005114 Integrase core domain; Region: rve; pfam00665 336982005115 Integrase core domain; Region: rve_3; pfam13683 336982005116 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 336982005117 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 336982005118 Uncharacterized conserved protein [Function unknown]; Region: COG0393 336982005119 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 336982005120 Domain of unknown function (DUF222); Region: DUF222; pfam02720 336982005121 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 336982005122 active site 336982005123 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 336982005124 Transposase; Region: HTH_Tnp_1; cl17663 336982005125 putative transposase OrfB; Reviewed; Region: PHA02517 336982005126 HTH-like domain; Region: HTH_21; pfam13276 336982005127 Integrase core domain; Region: rve; pfam00665 336982005128 Integrase core domain; Region: rve_3; pfam13683 336982005129 Integrase core domain; Region: rve; pfam00665 336982005130 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 336982005131 putative homotetramer interface [polypeptide binding]; other site 336982005132 putative homodimer interface [polypeptide binding]; other site 336982005133 putative allosteric switch controlling residues; other site 336982005134 putative metal binding site [ion binding]; other site 336982005135 putative homodimer-homodimer interface [polypeptide binding]; other site 336982005136 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 336982005137 PE family; Region: PE; pfam00934 336982005138 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 336982005139 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 336982005140 dimer interface [polypeptide binding]; other site 336982005141 active site 336982005142 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 336982005143 substrate binding site [chemical binding]; other site 336982005144 catalytic residue [active] 336982005145 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 336982005146 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 336982005147 metal binding site [ion binding]; metal-binding site 336982005148 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 336982005149 FAD binding domain; Region: FAD_binding_4; pfam01565 336982005150 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 336982005151 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 336982005152 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 336982005153 Transcriptional regulator [Transcription]; Region: IclR; COG1414 336982005154 Bacterial transcriptional regulator; Region: IclR; pfam01614 336982005155 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 336982005156 FAD binding domain; Region: FAD_binding_4; pfam01565 336982005157 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982005158 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982005159 cytochrome p450 144 CYP144; Mapped to H37Rv Rv1777; interrupted by transposase 336982005160 putative transposase OrfB; Reviewed; Region: PHA02517 336982005161 HTH-like domain; Region: HTH_21; pfam13276 336982005162 Integrase core domain; Region: rve; pfam00665 336982005163 Integrase core domain; Region: rve_3; pfam13683 336982005164 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 336982005165 Transposase; Region: HTH_Tnp_1; cl17663 336982005166 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 336982005167 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 336982005168 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 336982005169 Protein of unknown function (DUF690); Region: DUF690; pfam05108 336982005170 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 336982005171 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 336982005172 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 336982005173 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 336982005174 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 336982005175 Cytochrome P450; Region: p450; cl12078 336982005176 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 336982005177 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982005178 PPE family; Region: PPE; pfam00823 336982005179 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 336982005180 PE family; Region: PE; pfam00934 336982005181 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982005182 PPE family; Region: PPE; pfam00823 336982005183 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 336982005184 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982005185 PPE family; Region: PPE; pfam00823 336982005186 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 336982005187 PE family; Region: PE; pfam00934 336982005188 Esat-6 like protein esxM; Mapped to H37Rv Rv1792 336982005189 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 336982005190 EspG family; Region: ESX-1_EspG; pfam14011 336982005191 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 336982005192 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 336982005193 catalytic residues [active] 336982005194 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 336982005195 active site 336982005196 catalytic residues [active] 336982005197 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 336982005198 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 336982005199 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 336982005200 Walker A motif; other site 336982005201 ATP binding site [chemical binding]; other site 336982005202 Walker B motif; other site 336982005203 arginine finger; other site 336982005204 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982005205 PPE family; Region: PPE; pfam00823 336982005206 PE-PPE domain; Region: PE-PPE; pfam08237 336982005207 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982005208 PPE family; Region: PPE; pfam00823 336982005209 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982005210 PPE family; Region: PPE; pfam00823 336982005211 PE family; Region: PE; pfam00934 336982005212 Protein of unknown function (DUF732); Region: DUF732; pfam05305 336982005213 PE family; Region: PE; pfam00934 336982005214 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982005215 PPE family; Region: PPE; pfam00823 336982005216 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982005217 PPE family; Region: PPE; pfam00823 336982005218 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982005219 PPE family; Region: PPE; pfam00823 336982005220 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 336982005221 Protein of unknown function (DUF732); Region: DUF732; pfam05305 336982005222 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 336982005223 MgtC family; Region: MgtC; pfam02308 336982005224 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 336982005225 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 336982005226 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 336982005227 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 336982005228 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 336982005229 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982005230 hypothetical protein; Validated; Region: PRK07121 336982005231 PE family; Region: PE; pfam00934 336982005232 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 336982005233 ABC transporter transmembrane region 2; Region: ABC_membrane_2; pfam06472 336982005234 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 336982005235 hypothetical protein; Provisional; Region: PRK05858 336982005236 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 336982005237 PYR/PP interface [polypeptide binding]; other site 336982005238 dimer interface [polypeptide binding]; other site 336982005239 TPP binding site [chemical binding]; other site 336982005240 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 336982005241 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 336982005242 TPP-binding site; other site 336982005243 dimer interface [polypeptide binding]; other site 336982005244 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 336982005245 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 336982005246 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 336982005247 nucleotide binding region [chemical binding]; other site 336982005248 ATP-binding site [chemical binding]; other site 336982005249 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 336982005250 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 336982005251 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 336982005252 Uncharacterized conserved protein (small basic protein) [Function unknown]; Region: Sbp; COG3856 336982005253 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 336982005254 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 336982005255 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 336982005256 lipoyl attachment site [posttranslational modification]; other site 336982005257 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 336982005258 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 336982005259 phosphopeptide binding site; other site 336982005260 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 336982005261 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 336982005262 DNA binding residues [nucleotide binding] 336982005263 Bifunctional nuclease; Region: DNase-RNase; pfam02577 336982005264 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 336982005265 DNA binding residues [nucleotide binding] 336982005266 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 336982005267 putative dimer interface [polypeptide binding]; other site 336982005268 glycine dehydrogenase; Provisional; Region: PRK05367 336982005269 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 336982005270 pyridoxal 5'-phosphate binding site [chemical binding]; other site 336982005271 tetramer interface [polypeptide binding]; other site 336982005272 catalytic residue [active] 336982005273 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 336982005274 tetramer interface [polypeptide binding]; other site 336982005275 pyridoxal 5'-phosphate binding site [chemical binding]; other site 336982005276 catalytic residue [active] 336982005277 haloalkane dehalogenase; Provisional; Region: PRK03204 336982005278 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 336982005279 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 336982005280 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 336982005281 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 336982005282 metal ion-dependent adhesion site (MIDAS); other site 336982005283 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 336982005284 active site 336982005285 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 336982005286 putative active site [active] 336982005287 Domain of unknown function DUF21; Region: DUF21; pfam01595 336982005288 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 336982005289 FOG: CBS domain [General function prediction only]; Region: COG0517 336982005290 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 336982005291 Domain of unknown function DUF21; Region: DUF21; pfam01595 336982005292 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 336982005293 Transporter associated domain; Region: CorC_HlyC; smart01091 336982005294 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 336982005295 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 336982005296 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 336982005297 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 336982005298 active site 336982005299 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 336982005300 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 336982005301 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 336982005302 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 336982005303 Predicted transcriptional regulator [Transcription]; Region: COG3682 336982005304 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 336982005305 CoenzymeA binding site [chemical binding]; other site 336982005306 subunit interaction site [polypeptide binding]; other site 336982005307 PHB binding site; other site 336982005308 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 336982005309 alpha-gamma subunit interface [polypeptide binding]; other site 336982005310 beta-gamma subunit interface [polypeptide binding]; other site 336982005311 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 336982005312 gamma-beta subunit interface [polypeptide binding]; other site 336982005313 alpha-beta subunit interface [polypeptide binding]; other site 336982005314 urease subunit alpha; Reviewed; Region: ureC; PRK13206 336982005315 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 336982005316 subunit interactions [polypeptide binding]; other site 336982005317 active site 336982005318 flap region; other site 336982005319 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 336982005320 UreF; Region: UreF; pfam01730 336982005321 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 336982005322 UreD urease accessory protein; Region: UreD; cl00530 336982005323 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 336982005324 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 336982005325 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 336982005326 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 336982005327 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 336982005328 classical (c) SDRs; Region: SDR_c; cd05233 336982005329 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 336982005330 NAD(P) binding site [chemical binding]; other site 336982005331 active site 336982005332 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 336982005333 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 336982005334 sulfate transport protein; Provisional; Region: cysT; CHL00187 336982005335 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 336982005336 dimer interface [polypeptide binding]; other site 336982005337 conserved gate region; other site 336982005338 putative PBP binding loops; other site 336982005339 ABC-ATPase subunit interface; other site 336982005340 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 336982005341 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 336982005342 Walker A/P-loop; other site 336982005343 ATP binding site [chemical binding]; other site 336982005344 Q-loop/lid; other site 336982005345 ABC transporter signature motif; other site 336982005346 Walker B; other site 336982005347 D-loop; other site 336982005348 H-loop/switch region; other site 336982005349 TOBE domain; Region: TOBE; pfam03459 336982005350 Fibronectin-attachment protein (FAP); Region: FAP; pfam07174 336982005351 Predicted membrane protein [Function unknown]; Region: COG2261 336982005352 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 336982005353 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 336982005354 putative NAD(P) binding site [chemical binding]; other site 336982005355 putative substrate binding site [chemical binding]; other site 336982005356 catalytic Zn binding site [ion binding]; other site 336982005357 structural Zn binding site [ion binding]; other site 336982005358 CAAX protease self-immunity; Region: Abi; pfam02517 336982005359 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 336982005360 MOSC domain; Region: MOSC; pfam03473 336982005361 short chain dehydrogenase; Provisional; Region: PRK07825 336982005362 classical (c) SDRs; Region: SDR_c; cd05233 336982005363 NAD(P) binding site [chemical binding]; other site 336982005364 active site 336982005365 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 336982005366 CoA-transferase family III; Region: CoA_transf_3; pfam02515 336982005367 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 336982005368 CoA-transferase family III; Region: CoA_transf_3; pfam02515 336982005369 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 336982005370 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 336982005371 active site 336982005372 hypothetical protein; Provisional; Region: PRK12320 336982005373 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982005374 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 336982005375 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 336982005376 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 336982005377 Domain of unknown function (DUF385); Region: DUF385; pfam04075 336982005378 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 336982005379 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 336982005380 active site 336982005381 substrate binding site [chemical binding]; other site 336982005382 FMN binding site [chemical binding]; other site 336982005383 putative catalytic residues [active] 336982005384 Uncharacterized conserved protein [Function unknown]; Region: COG5579 336982005385 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 336982005386 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 336982005387 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 336982005388 heme binding site [chemical binding]; other site 336982005389 ferroxidase pore; other site 336982005390 ferroxidase diiron center [ion binding]; other site 336982005391 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 336982005392 Major Facilitator Superfamily; Region: MFS_1; pfam07690 336982005393 putative substrate translocation pore; other site 336982005394 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 336982005395 putative substrate translocation pore; other site 336982005396 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cl00333 336982005397 23S rRNA interface [nucleotide binding]; other site 336982005398 L3 interface [polypeptide binding]; other site 336982005399 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 336982005400 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 336982005401 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 336982005402 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 336982005403 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 336982005404 Cytochrome P450; Region: p450; cl12078 336982005405 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 336982005406 short chain dehydrogenase; Provisional; Region: PRK08267 336982005407 classical (c) SDR, subgroup 9; Region: SDR_c9; cd08931 336982005408 putative NAD(P) binding site [chemical binding]; other site 336982005409 active site 336982005410 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 336982005411 hydrophobic ligand binding site; other site 336982005412 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 336982005413 chorismate mutase; Provisional; Region: PRK09269 336982005414 chorismate mutase, putative; Region: CM_mono2; TIGR01806 336982005415 Putative esterase; Region: Esterase; pfam00756 336982005416 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 336982005417 Leucine carboxyl methyltransferase; Region: LCM; cl01306 336982005418 Uncharacterized conserved protein [Function unknown]; Region: COG2353 336982005419 Nitronate monooxygenase; Region: NMO; pfam03060 336982005420 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 336982005421 FMN binding site [chemical binding]; other site 336982005422 substrate binding site [chemical binding]; other site 336982005423 putative catalytic residue [active] 336982005424 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 2; Region: FDH_like_2; cd08284 336982005425 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 336982005426 catalytic Zn binding site [ion binding]; other site 336982005427 NAD(P) binding site [chemical binding]; other site 336982005428 structural Zn binding site [ion binding]; other site 336982005429 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 336982005430 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 336982005431 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 336982005432 putative active site [active] 336982005433 dimerization interface [polypeptide binding]; other site 336982005434 putative tRNAtyr binding site [nucleotide binding]; other site 336982005435 Domain of unknown function DUF77; Region: DUF77; pfam01910 336982005436 Macro domain, Unknown family 2. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_2; cd03330 336982005437 putative ADP-ribose binding site [chemical binding]; other site 336982005438 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 336982005439 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 336982005440 cyclase homology domain; Region: CHD; cd07302 336982005441 nucleotidyl binding site; other site 336982005442 metal binding site [ion binding]; metal-binding site 336982005443 dimer interface [polypeptide binding]; other site 336982005444 competence damage-inducible protein A; Provisional; Region: PRK00549 336982005445 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 336982005446 putative MPT binding site; other site 336982005447 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 336982005448 putative sialic acid transporter; Region: 2A0112; TIGR00891 336982005449 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 336982005450 putative substrate translocation pore; other site 336982005451 Predicted membrane protein [Function unknown]; Region: COG1950 336982005452 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 336982005453 anti sigma factor interaction site; other site 336982005454 regulatory phosphorylation site [posttranslational modification]; other site 336982005455 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 336982005456 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 336982005457 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 336982005458 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 336982005459 dimer interface [polypeptide binding]; other site 336982005460 active site 336982005461 heme binding site [chemical binding]; other site 336982005462 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 336982005463 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 336982005464 metal binding site 2 [ion binding]; metal-binding site 336982005465 putative DNA binding helix; other site 336982005466 metal binding site 1 [ion binding]; metal-binding site 336982005467 dimer interface [polypeptide binding]; other site 336982005468 structural Zn2+ binding site [ion binding]; other site 336982005469 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 336982005470 substrate binding site [chemical binding]; other site 336982005471 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 336982005472 substrate binding site [chemical binding]; other site 336982005473 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 336982005474 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR3; cd08275 336982005475 putative NAD(P) binding site [chemical binding]; other site 336982005476 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 336982005477 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 336982005478 tetramer interface [polypeptide binding]; other site 336982005479 active site 336982005480 Mg2+/Mn2+ binding site [ion binding]; other site 336982005481 Isocitrate lyase [Energy production and conversion]; Region: AceA; COG2224 336982005482 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982005483 PPE family; Region: PPE; pfam00823 336982005484 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982005485 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982005486 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982005487 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982005488 PPE family; Region: PPE; pfam00823 336982005489 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982005490 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982005491 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 336982005492 putative hydrophobic ligand binding site [chemical binding]; other site 336982005493 protein interface [polypeptide binding]; other site 336982005494 gate; other site 336982005495 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 336982005496 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 336982005497 putative acyl-acceptor binding pocket; other site 336982005498 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 336982005499 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 336982005500 Beta-lactamase; Region: Beta-lactamase; pfam00144 336982005501 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 336982005502 Beta-lactamase; Region: Beta-lactamase; pfam00144 336982005503 putative fatty-acid--CoA ligase; Provisional; Region: PRK12476 336982005504 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 336982005505 acyl-activating enzyme (AAE) consensus motif; other site 336982005506 active site 336982005507 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 336982005508 Uncharacterized conserved protein [Function unknown]; Region: COG3361 336982005509 short chain dehydrogenase; Provisional; Region: PRK05867 336982005510 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982005511 NAD(P) binding site [chemical binding]; other site 336982005512 active site 336982005513 TIGR03085 family protein; Region: TIGR03085 336982005514 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 336982005515 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 336982005516 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 336982005517 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 336982005518 conserved cys residue [active] 336982005519 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 336982005520 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 336982005521 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 336982005522 dimer interface [polypeptide binding]; other site 336982005523 catalytic triad [active] 336982005524 peroxidatic and resolving cysteines [active] 336982005525 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 336982005526 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 336982005527 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 336982005528 active site 336982005529 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 336982005530 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 336982005531 FAD binding site [chemical binding]; other site 336982005532 substrate binding site [chemical binding]; other site 336982005533 catalytic base [active] 336982005534 enoyl-CoA hydratase; Provisional; Region: PRK08290 336982005535 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 336982005536 substrate binding site [chemical binding]; other site 336982005537 oxyanion hole (OAH) forming residues; other site 336982005538 trimer interface [polypeptide binding]; other site 336982005539 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 336982005540 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 336982005541 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 336982005542 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 336982005543 catalytic loop [active] 336982005544 iron binding site [ion binding]; other site 336982005545 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 336982005546 FAD binding pocket [chemical binding]; other site 336982005547 FAD binding motif [chemical binding]; other site 336982005548 phosphate binding motif [ion binding]; other site 336982005549 beta-alpha-beta structure motif; other site 336982005550 NAD binding pocket [chemical binding]; other site 336982005551 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 336982005552 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 336982005553 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 336982005554 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 336982005555 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 336982005556 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 336982005557 dimerization interface [polypeptide binding]; other site 336982005558 active site 336982005559 classical (c) SDR, subgroup 12; Region: SDR_c12; cd08944 336982005560 putative NAD(P) binding site [chemical binding]; other site 336982005561 active site 336982005562 homodimer interface [polypeptide binding]; other site 336982005563 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 336982005564 SEC-C motif; Region: SEC-C; pfam02810 336982005565 Domain of unknown function (DUF222); Region: DUF222; pfam02720 336982005566 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 336982005567 active site 336982005568 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 336982005569 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487 336982005570 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 336982005571 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 336982005572 non-specific DNA binding site [nucleotide binding]; other site 336982005573 salt bridge; other site 336982005574 sequence-specific DNA binding site [nucleotide binding]; other site 336982005575 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 336982005576 Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693 336982005577 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 336982005578 putative active site [active] 336982005579 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 336982005580 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982005581 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982005582 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982005583 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982005584 Permease; Region: Permease; cl00510 336982005585 Permease; Region: Permease; pfam02405 336982005586 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 336982005587 Permease; Region: Permease; pfam02405 336982005588 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 336982005589 mce related protein; Region: MCE; pfam02470 336982005590 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 336982005591 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 336982005592 mce related protein; Region: MCE; pfam02470 336982005593 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 336982005594 mce related protein; Region: MCE; pfam02470 336982005595 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 336982005596 mce related protein; Region: MCE; pfam02470 336982005597 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 336982005598 mce related protein; Region: MCE; pfam02470 336982005599 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 336982005600 mce related protein; Region: MCE; pfam02470 336982005601 Protein of unknown function (DUF732); Region: DUF732; pfam05305 336982005602 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 336982005603 YacP-like NYN domain; Region: NYN_YacP; cl01491 336982005604 Peptidase family M48; Region: Peptidase_M48; pfam01435 336982005605 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 336982005606 S-adenosylmethionine binding site [chemical binding]; other site 336982005607 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 336982005608 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 336982005609 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 336982005610 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 336982005611 dimer interface [polypeptide binding]; other site 336982005612 putative radical transfer pathway; other site 336982005613 diiron center [ion binding]; other site 336982005614 tyrosyl radical; other site 336982005615 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 336982005616 putative active site [active] 336982005617 PE family; Region: PE; pfam00934 336982005618 Cutinase; Region: Cutinase; pfam01083 336982005619 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 336982005620 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 336982005621 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 336982005622 dimerization interface [polypeptide binding]; other site 336982005623 Lysine efflux permease [General function prediction only]; Region: COG1279 336982005624 Cellulose binding domain; Region: CBM_2; pfam00553 336982005625 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 336982005626 S-adenosylmethionine binding site [chemical binding]; other site 336982005627 Uncharacterized conserved protein [Function unknown]; Region: COG5654 336982005628 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 336982005629 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 336982005630 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982005631 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 336982005632 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 336982005633 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 336982005634 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 336982005635 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 336982005636 dimerization interface [polypeptide binding]; other site 336982005637 putative DNA binding site [nucleotide binding]; other site 336982005638 putative Zn2+ binding site [ion binding]; other site 336982005639 Hemerythrin-like domain; Region: Hr-like; cd12108 336982005640 Fe binding site [ion binding]; other site 336982005641 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 336982005642 Ligand Binding Site [chemical binding]; other site 336982005643 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 336982005644 Ligand Binding Site [chemical binding]; other site 336982005645 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 336982005646 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 336982005647 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 336982005648 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 336982005649 Soluble P-type ATPase [General function prediction only]; Region: COG4087 336982005650 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 336982005651 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 336982005652 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 336982005653 tetramer interface [polypeptide binding]; other site 336982005654 active site 336982005655 Mg2+/Mn2+ binding site [ion binding]; other site 336982005656 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 336982005657 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 336982005658 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 336982005659 3beta17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 3beta-17beta-HSD_like_SDR_c; cd05341 336982005660 homotetramer interface [polypeptide binding]; other site 336982005661 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 336982005662 NAD binding site [chemical binding]; other site 336982005663 homodimer interface [polypeptide binding]; other site 336982005664 active site 336982005665 Methyltransferase domain; Region: Methyltransf_23; pfam13489 336982005666 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 336982005667 S-adenosylmethionine binding site [chemical binding]; other site 336982005668 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 336982005669 Predicted kinase [General function prediction only]; Region: COG0645 336982005670 AAA domain; Region: AAA_17; pfam13207 336982005671 Universal stress protein family; Region: Usp; pfam00582 336982005672 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 336982005673 Ligand Binding Site [chemical binding]; other site 336982005674 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 336982005675 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 336982005676 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 336982005677 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 336982005678 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 336982005679 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 336982005680 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 336982005681 Ferredoxin [Energy production and conversion]; Region: COG1146 336982005682 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 336982005683 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 336982005684 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 336982005685 Walker A motif; other site 336982005686 ATP binding site [chemical binding]; other site 336982005687 Walker B motif; other site 336982005688 arginine finger; other site 336982005689 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 336982005690 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 336982005691 putative active site [active] 336982005692 Transcriptional regulators [Transcription]; Region: MarR; COG1846 336982005693 MarR family; Region: MarR_2; pfam12802 336982005694 Phage envelope protein [General function prediction only]; Region: COG5562 336982005695 Transposase; Region: DEDD_Tnp_IS110; pfam01548 336982005696 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 336982005697 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 336982005698 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 336982005699 conserved hypothetical protein; Mapped to H37Rv Rv2015c; interrupted by transposases 336982005700 putative transposase OrfB; Reviewed; Region: PHA02517 336982005701 HTH-like domain; Region: HTH_21; pfam13276 336982005702 Integrase core domain; Region: rve; pfam00665 336982005703 Integrase core domain; Region: rve_3; pfam13683 336982005704 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 336982005705 Transposase; Region: HTH_Tnp_1; cl17663 336982005706 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 336982005707 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 336982005708 non-specific DNA binding site [nucleotide binding]; other site 336982005709 salt bridge; other site 336982005710 sequence-specific DNA binding site [nucleotide binding]; other site 336982005711 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 336982005712 Uncharacterized conserved protein [Function unknown]; Region: COG2442 336982005713 hypothetical helicase; Mapped to H37Rv Rv2020c; interrupted gene 336982005714 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 336982005715 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 336982005716 non-specific DNA binding site [nucleotide binding]; other site 336982005717 salt bridge; other site 336982005718 sequence-specific DNA binding site [nucleotide binding]; other site 336982005719 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4683 336982005720 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 336982005721 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 336982005722 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 336982005723 Ligand Binding Site [chemical binding]; other site 336982005724 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 336982005725 Ligand Binding Site [chemical binding]; other site 336982005726 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 336982005727 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 336982005728 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 336982005729 Histidine kinase; Region: HisKA_3; pfam07730 336982005730 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 336982005731 Ligand Binding Site [chemical binding]; other site 336982005732 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 336982005733 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 336982005734 putative substrate binding site [chemical binding]; other site 336982005735 putative ATP binding site [chemical binding]; other site 336982005736 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 336982005737 active site 336982005738 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 336982005739 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 336982005740 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 336982005741 putative dimer interface [polypeptide binding]; other site 336982005742 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 336982005743 dimer interface [polypeptide binding]; other site 336982005744 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 336982005745 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 336982005746 putative DNA binding site [nucleotide binding]; other site 336982005747 dimerization interface [polypeptide binding]; other site 336982005748 putative Zn2+ binding site [ion binding]; other site 336982005749 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 336982005750 putative hydrophobic ligand binding site [chemical binding]; other site 336982005751 CLM binding site; other site 336982005752 L1 loop; other site 336982005753 DNA binding site [nucleotide binding] 336982005754 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 336982005755 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 336982005756 MDMPI C-terminal domain; Region: MDMPI_C; pfam07398 336982005757 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 336982005758 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 336982005759 nucleophile elbow; other site 336982005760 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 336982005761 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 336982005762 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 336982005763 Walker A/P-loop; other site 336982005764 ATP binding site [chemical binding]; other site 336982005765 Q-loop/lid; other site 336982005766 ABC transporter signature motif; other site 336982005767 Walker B; other site 336982005768 D-loop; other site 336982005769 H-loop/switch region; other site 336982005770 TOBE domain; Region: TOBE_2; pfam08402 336982005771 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 336982005772 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 336982005773 dimer interface [polypeptide binding]; other site 336982005774 conserved gate region; other site 336982005775 putative PBP binding loops; other site 336982005776 ABC-ATPase subunit interface; other site 336982005777 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 336982005778 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 336982005779 dimer interface [polypeptide binding]; other site 336982005780 conserved gate region; other site 336982005781 putative PBP binding loops; other site 336982005782 ABC-ATPase subunit interface; other site 336982005783 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 336982005784 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 336982005785 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 336982005786 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 336982005787 Isochorismatase family; Region: Isochorismatase; pfam00857 336982005788 catalytic triad [active] 336982005789 metal binding site [ion binding]; metal-binding site 336982005790 conserved cis-peptide bond; other site 336982005791 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 336982005792 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 336982005793 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 336982005794 substrate binding pocket [chemical binding]; other site 336982005795 catalytic triad [active] 336982005796 hypothetical protein; Provisional; Region: PRK05865 336982005797 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982005798 NAD(P) binding site [chemical binding]; other site 336982005799 active site 336982005800 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 336982005801 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 336982005802 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 336982005803 active site 336982005804 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 336982005805 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 336982005806 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982005807 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 336982005808 Enoylreductase; Region: PKS_ER; smart00829 336982005809 NAD(P) binding site [chemical binding]; other site 336982005810 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 336982005811 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 336982005812 putative NADP binding site [chemical binding]; other site 336982005813 active site 336982005814 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 336982005815 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 336982005816 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 336982005817 active site 336982005818 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 336982005819 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 336982005820 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982005821 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 336982005822 Enoylreductase; Region: PKS_ER; smart00829 336982005823 NAD(P) binding site [chemical binding]; other site 336982005824 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 336982005825 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 336982005826 putative NADP binding site [chemical binding]; other site 336982005827 active site 336982005828 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 336982005829 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 336982005830 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 336982005831 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 336982005832 putative active site [active] 336982005833 catalytic triad [active] 336982005834 putative dimer interface [polypeptide binding]; other site 336982005835 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 336982005836 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 336982005837 Ligand binding site; other site 336982005838 Putative Catalytic site; other site 336982005839 DXD motif; other site 336982005840 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 336982005841 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 336982005842 active site 336982005843 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 336982005844 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 336982005845 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 336982005846 30S ribosomal protein S18; Provisional; Region: PRK13401 336982005847 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 336982005848 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 336982005849 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 336982005850 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 336982005851 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 336982005852 intersubunit interface [polypeptide binding]; other site 336982005853 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 336982005854 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 336982005855 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 336982005856 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 336982005857 precorrin-3B synthase; Region: CobG; TIGR02435 336982005858 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 336982005859 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 336982005860 Precorrin-8X methylmutase; Region: CbiC; pfam02570 336982005861 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 336982005862 active site 336982005863 SAM binding site [chemical binding]; other site 336982005864 homodimer interface [polypeptide binding]; other site 336982005865 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 336982005866 active site 336982005867 SAM binding site [chemical binding]; other site 336982005868 homodimer interface [polypeptide binding]; other site 336982005869 Methyltransferase domain; Region: Methyltransf_31; pfam13847 336982005870 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 336982005871 S-adenosylmethionine binding site [chemical binding]; other site 336982005872 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 336982005873 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 336982005874 RNA polymerase sigma factor SigC; Reviewed; Region: PRK09649 336982005875 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 336982005876 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 336982005877 DNA binding residues [nucleotide binding] 336982005878 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 336982005879 precorrin-6x reductase; Region: precor6x_red; TIGR00715 336982005880 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 336982005881 active site 336982005882 SAM binding site [chemical binding]; other site 336982005883 homodimer interface [polypeptide binding]; other site 336982005884 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 336982005885 active site 336982005886 putative homodimer interface [polypeptide binding]; other site 336982005887 SAM binding site [chemical binding]; other site 336982005888 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 336982005889 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 336982005890 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982005891 NAD(P) binding site [chemical binding]; other site 336982005892 active site 336982005893 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 336982005894 Catalytic domain of uncharacterized Mycobacterium tuberculosis Rv2075c-like proteins; Region: PI-PLCc_Rv2075c_like; cd08590 336982005895 putative active site [active] 336982005896 catalytic site [active] 336982005897 putative metal binding site [ion binding]; other site 336982005898 C-type lectin (CTL)/C-type lectin-like (CTLD) domain; Region: CLECT; cl02432 336982005899 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 336982005900 Transposase; Region: HTH_Tnp_1; cl17663 336982005901 putative transposase OrfB; Reviewed; Region: PHA02517 336982005902 HTH-like domain; Region: HTH_21; pfam13276 336982005903 Integrase core domain; Region: rve; pfam00665 336982005904 Integrase core domain; Region: rve_3; pfam13683 336982005905 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 336982005906 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 336982005907 Catalytic domain of Protein Kinases; Region: PKc; cd00180 336982005908 active site 336982005909 ATP binding site [chemical binding]; other site 336982005910 substrate binding site [chemical binding]; other site 336982005911 activation loop (A-loop); other site 336982005912 PknH-like extracellular domain; Region: PknH_C; pfam14032 336982005913 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 336982005914 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 336982005915 active site 336982005916 5'-3' exonuclease, N-terminal resolvase-like domain; Region: 5_3_exonuc_N; pfam02739 336982005917 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 336982005918 active site 336982005919 metal binding site 1 [ion binding]; metal-binding site 336982005920 putative 5' ssDNA interaction site; other site 336982005921 metal binding site 3; metal-binding site 336982005922 metal binding site 2 [ion binding]; metal-binding site 336982005923 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 336982005924 putative DNA binding site [nucleotide binding]; other site 336982005925 putative metal binding site [ion binding]; other site 336982005926 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 336982005927 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 336982005928 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 336982005929 ATP binding site [chemical binding]; other site 336982005930 putative Mg++ binding site [ion binding]; other site 336982005931 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 336982005932 nucleotide binding region [chemical binding]; other site 336982005933 ATP-binding site [chemical binding]; other site 336982005934 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 336982005935 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 336982005936 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 336982005937 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 336982005938 Predicted transcriptional regulator [Transcription]; Region: COG2378 336982005939 WYL domain; Region: WYL; pfam13280 336982005940 Predicted transcriptional regulator [Transcription]; Region: COG2378 336982005941 WYL domain; Region: WYL; pfam13280 336982005942 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 336982005943 Domain of unknown function (DUF222); Region: DUF222; pfam02720 336982005944 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 336982005945 active site 336982005946 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 336982005947 SNF2 Helicase protein; Region: DUF3670; pfam12419 336982005948 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 336982005949 ATP binding site [chemical binding]; other site 336982005950 putative Mg++ binding site [ion binding]; other site 336982005951 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 336982005952 nucleotide binding region [chemical binding]; other site 336982005953 ATP-binding site [chemical binding]; other site 336982005954 Uncharacterized conserved protein [Function unknown]; Region: COG4279 336982005955 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 336982005956 putative active site [active] 336982005957 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982005958 PPE family; Region: PPE; pfam00823 336982005959 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 336982005960 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 336982005961 active site 336982005962 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 336982005963 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 336982005964 active site 336982005965 Pup-like protein; Region: Pup; pfam05639 336982005966 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 336982005967 proteasome ATPase; Region: pup_AAA; TIGR03689 336982005968 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 336982005969 Walker A motif; other site 336982005970 ATP binding site [chemical binding]; other site 336982005971 Walker B motif; other site 336982005972 arginine finger; other site 336982005973 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 336982005974 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550 336982005975 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 336982005976 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 336982005977 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 336982005978 Predicted membrane protein [Function unknown]; Region: COG3918 336982005979 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 336982005980 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 336982005981 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 336982005982 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 336982005983 homodimer interface [polypeptide binding]; other site 336982005984 putative metal binding site [ion binding]; other site 336982005985 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982005986 PPE family; Region: PPE; pfam00823 336982005987 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 336982005988 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 336982005989 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 336982005990 substrate binding pocket [chemical binding]; other site 336982005991 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 336982005992 B12 binding site [chemical binding]; other site 336982005993 cobalt ligand [ion binding]; other site 336982005994 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 336982005995 PAC2 family; Region: PAC2; pfam09754 336982005996 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 336982005997 short chain dehydrogenase; Provisional; Region: PRK05872 336982005998 classical (c) SDRs; Region: SDR_c; cd05233 336982005999 NAD(P) binding site [chemical binding]; other site 336982006000 active site 336982006001 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 336982006002 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 336982006003 active site 336982006004 HIGH motif; other site 336982006005 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 336982006006 active site 336982006007 KMSKS motif; other site 336982006008 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 336982006009 putative tRNA binding surface [nucleotide binding]; other site 336982006010 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 336982006011 active site 336982006012 conserved hypothetical protein; Region: TIGR03843 336982006013 conserved hypothetical protein; Region: TIGR03847 336982006014 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 336982006015 catalytic core [active] 336982006016 undecaprenyl-diphosphatase UppP; Region: undec_PP_bacA; TIGR00753 336982006017 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 336982006018 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 336982006019 quinone interaction residues [chemical binding]; other site 336982006020 active site 336982006021 catalytic residues [active] 336982006022 FMN binding site [chemical binding]; other site 336982006023 substrate binding site [chemical binding]; other site 336982006024 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 336982006025 substrate binding site [chemical binding]; other site 336982006026 hypothetical protein; Provisional; Region: PRK07906 336982006027 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 336982006028 putative metal binding site [ion binding]; other site 336982006029 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 336982006030 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 336982006031 active site 336982006032 DivIVA domain; Region: DivI1A_domain; TIGR03544 336982006033 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 336982006034 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 336982006035 Predicted integral membrane protein [Function unknown]; Region: COG0762 336982006036 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 336982006037 Predicted enzyme with a TIM-barrel fold [General function prediction only]; Region: COG0325 336982006038 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 336982006039 catalytic residue [active] 336982006040 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 336982006041 uncharacterized protein, YfiH family; Region: TIGR00726 336982006042 cell division protein FtsZ; Validated; Region: PRK09330 336982006043 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 336982006044 nucleotide binding site [chemical binding]; other site 336982006045 SulA interaction site; other site 336982006046 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 336982006047 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 336982006048 Cell division protein FtsQ; Region: FtsQ; pfam03799 336982006049 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 336982006050 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 336982006051 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 336982006052 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 336982006053 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 336982006054 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 336982006055 active site 336982006056 homodimer interface [polypeptide binding]; other site 336982006057 cell division protein FtsW; Region: ftsW; TIGR02614 336982006058 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369 336982006059 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 336982006060 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 336982006061 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 336982006062 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 336982006063 Mg++ binding site [ion binding]; other site 336982006064 putative catalytic motif [active] 336982006065 putative substrate binding site [chemical binding]; other site 336982006066 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 336982006067 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 336982006068 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 336982006069 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 336982006070 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 336982006071 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 336982006072 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 336982006073 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982006074 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982006075 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 336982006076 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 336982006077 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 336982006078 PE family; Region: PE; pfam00934 336982006079 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 336982006080 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 336982006081 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 336982006082 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 336982006083 MraW methylase family; Region: Methyltransf_5; pfam01795 336982006084 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 336982006085 MraZ protein; Region: MraZ; pfam02381 336982006086 MraZ protein; Region: MraZ; pfam02381 336982006087 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 336982006088 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 336982006089 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 336982006090 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 336982006091 substrate binding pocket [chemical binding]; other site 336982006092 chain length determination region; other site 336982006093 substrate-Mg2+ binding site; other site 336982006094 catalytic residues [active] 336982006095 aspartate-rich region 1; other site 336982006096 active site lid residues [active] 336982006097 aspartate-rich region 2; other site 336982006098 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 336982006099 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 336982006100 Catalytic domain of Protein Kinases; Region: PKc; cd00180 336982006101 active site 336982006102 ATP binding site [chemical binding]; other site 336982006103 substrate binding site [chemical binding]; other site 336982006104 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 336982006105 substrate binding site [chemical binding]; other site 336982006106 activation loop (A-loop); other site 336982006107 activation loop (A-loop); other site 336982006108 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 336982006109 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 336982006110 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG3200 336982006111 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 336982006112 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 336982006113 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 336982006114 putative acyl-acceptor binding pocket; other site 336982006115 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 336982006116 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 336982006117 DTAP/Switch II; other site 336982006118 Switch I; other site 336982006119 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 336982006120 putative hydrophobic ligand binding site [chemical binding]; other site 336982006121 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 336982006122 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 336982006123 acyl-activating enzyme (AAE) consensus motif; other site 336982006124 putative AMP binding site [chemical binding]; other site 336982006125 putative active site [active] 336982006126 putative CoA binding site [chemical binding]; other site 336982006127 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 336982006128 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 336982006129 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 336982006130 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 336982006131 NlpC/P60 family; Region: NLPC_P60; pfam00877 336982006132 hypothetical protein; Validated; Region: PRK07883 336982006133 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 336982006134 active site 336982006135 catalytic site [active] 336982006136 substrate binding site [chemical binding]; other site 336982006137 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 336982006138 GIY-YIG motif/motif A; other site 336982006139 active site 336982006140 catalytic site [active] 336982006141 putative DNA binding site [nucleotide binding]; other site 336982006142 metal binding site [ion binding]; metal-binding site 336982006143 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 336982006144 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 336982006145 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 336982006146 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 336982006147 Subunit I/III interface [polypeptide binding]; other site 336982006148 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 336982006149 Cytochrome c; Region: Cytochrom_C; pfam00034 336982006150 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 336982006151 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 336982006152 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 336982006153 iron-sulfur cluster [ion binding]; other site 336982006154 [2Fe-2S] cluster binding site [ion binding]; other site 336982006155 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 336982006156 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 336982006157 heme bH binding site [chemical binding]; other site 336982006158 intrachain domain interface; other site 336982006159 heme bL binding site [chemical binding]; other site 336982006160 interchain domain interface [polypeptide binding]; other site 336982006161 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 336982006162 Qo binding site; other site 336982006163 Protein of unknown function (DUF2561); Region: DUF2561; pfam10812 336982006164 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 336982006165 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 336982006166 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 336982006167 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 336982006168 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 336982006169 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 336982006170 dimer interface [polypeptide binding]; other site 336982006171 active site 336982006172 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 336982006173 Ligand Binding Site [chemical binding]; other site 336982006174 Molecular Tunnel; other site 336982006175 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 336982006176 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 336982006177 substrate binding site [chemical binding]; other site 336982006178 ATP binding site [chemical binding]; other site 336982006179 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 336982006180 Glycerate kinase family; Region: Gly_kinase; cl00841 336982006181 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 336982006182 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 336982006183 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 336982006184 putative dimer interface [polypeptide binding]; other site 336982006185 active site pocket [active] 336982006186 putative cataytic base [active] 336982006187 Cobalamin-5-phosphate synthase; Region: CobS; pfam02654 336982006188 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 336982006189 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 336982006190 homodimer interface [polypeptide binding]; other site 336982006191 substrate-cofactor binding pocket; other site 336982006192 catalytic residue [active] 336982006193 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 336982006194 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 336982006195 cyclase homology domain; Region: CHD; cd07302 336982006196 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 336982006197 nucleotidyl binding site; other site 336982006198 metal binding site [ion binding]; metal-binding site 336982006199 dimer interface [polypeptide binding]; other site 336982006200 multifunctional aminopeptidase A; Provisional; Region: PRK00913 336982006201 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 336982006202 interface (dimer of trimers) [polypeptide binding]; other site 336982006203 Substrate-binding/catalytic site; other site 336982006204 Zn-binding sites [ion binding]; other site 336982006205 short chain dehydrogenase; Validated; Region: PRK05855 336982006206 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 336982006207 classical (c) SDRs; Region: SDR_c; cd05233 336982006208 NAD(P) binding site [chemical binding]; other site 336982006209 active site 336982006210 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 336982006211 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 336982006212 E3 interaction surface; other site 336982006213 lipoyl attachment site [posttranslational modification]; other site 336982006214 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 336982006215 E3 interaction surface; other site 336982006216 lipoyl attachment site [posttranslational modification]; other site 336982006217 e3 binding domain; Region: E3_binding; pfam02817 336982006218 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 336982006219 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 336982006220 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 336982006221 putative NAD(P) binding site [chemical binding]; other site 336982006222 putative active site [active] 336982006223 lipoate-protein ligase B; Provisional; Region: PRK14345 336982006224 lipoyl synthase; Provisional; Region: PRK05481 336982006225 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 336982006226 FeS/SAM binding site; other site 336982006227 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 336982006228 RDD family; Region: RDD; pfam06271 336982006229 glutamine synthetase, type I; Region: GlnA; TIGR00653 336982006230 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 336982006231 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 336982006232 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 336982006233 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 336982006234 metal binding triad; other site 336982006235 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 336982006236 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 336982006237 metal binding triad; other site 336982006238 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 336982006239 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 336982006240 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 336982006241 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 336982006242 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 336982006243 TAP-like protein; Region: Abhydrolase_4; pfam08386 336982006244 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 336982006245 TAP-like protein; Region: Abhydrolase_4; pfam08386 336982006246 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 336982006247 oligomerization interface [polypeptide binding]; other site 336982006248 active site 336982006249 metal binding site [ion binding]; metal-binding site 336982006250 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 336982006251 putative active site; other site 336982006252 putative metal binding residues [ion binding]; other site 336982006253 signature motif; other site 336982006254 putative triphosphate binding site [ion binding]; other site 336982006255 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 336982006256 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3826 336982006257 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 336982006258 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 336982006259 RNA/DNA hybrid binding site [nucleotide binding]; other site 336982006260 active site 336982006261 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 336982006262 catalytic core [active] 336982006263 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 336982006264 Putative zinc ribbon domain; Region: DUF164; pfam02591 336982006265 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 336982006266 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 336982006267 Uncharacterized conserved protein [Function unknown]; Region: COG0327 336982006268 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 336982006269 hypothetical protein; Provisional; Region: PRK07908 336982006270 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 336982006271 pyridoxal 5'-phosphate binding site [chemical binding]; other site 336982006272 homodimer interface [polypeptide binding]; other site 336982006273 catalytic residue [active] 336982006274 PIN domain nuclease, a component of toxin-antitoxin system (PIN domain) [Signal transduction mechanisms]; Region: COG3744 336982006275 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 336982006276 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 336982006277 active site 336982006278 motif I; other site 336982006279 motif II; other site 336982006280 Low molecular weight phosphatase family; Region: LMWPc; cd00115 336982006281 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 336982006282 active site 336982006283 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 336982006284 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 336982006285 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 336982006286 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 336982006287 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 336982006288 dimer interface [polypeptide binding]; other site 336982006289 catalytic triad [active] 336982006290 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 336982006291 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 336982006292 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 336982006293 dimer interface [polypeptide binding]; other site 336982006294 TPP-binding site [chemical binding]; other site 336982006295 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 336982006296 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 336982006297 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 336982006298 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 336982006299 acyl carrier protein; Provisional; Region: acpP; PRK00982 336982006300 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 336982006301 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 336982006302 dimer interface [polypeptide binding]; other site 336982006303 active site 336982006304 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 336982006305 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 336982006306 dimer interface [polypeptide binding]; other site 336982006307 active site 336982006308 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 336982006309 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 336982006310 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 336982006311 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 336982006312 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 336982006313 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 336982006314 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982006315 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982006316 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 336982006317 FAD binding domain; Region: FAD_binding_4; pfam01565 336982006318 diacylglycerol kinase; Reviewed; Region: PRK11914 336982006319 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 336982006320 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 336982006321 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 336982006322 Beta-lactamase; Region: Beta-lactamase; pfam00144 336982006323 Methyltransferase domain; Region: Methyltransf_31; pfam13847 336982006324 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 336982006325 S-adenosylmethionine binding site [chemical binding]; other site 336982006326 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 336982006327 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 336982006328 NAD binding site [chemical binding]; other site 336982006329 catalytic Zn binding site [ion binding]; other site 336982006330 substrate binding site [chemical binding]; other site 336982006331 structural Zn binding site [ion binding]; other site 336982006332 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 336982006333 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 336982006334 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 336982006335 putative active site [active] 336982006336 catalytic triad [active] 336982006337 putative dimer interface [polypeptide binding]; other site 336982006338 short chain dehydrogenase; Provisional; Region: PRK05854 336982006339 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 336982006340 putative NAD(P) binding site [chemical binding]; other site 336982006341 active site 336982006342 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 336982006343 nucleotide binding site [chemical binding]; other site 336982006344 Major Facilitator Superfamily; Region: MFS_1; pfam07690 336982006345 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 336982006346 Cytochrome P450; Region: p450; cl12078 336982006347 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 336982006348 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 336982006349 Cytochrome P450; Region: p450; cl12078 336982006350 Septum formation; Region: Septum_form; pfam13845 336982006351 Protein of unknown function (DUF2695); Region: DUF2695; pfam10905 336982006352 Predicted membrane protein [Function unknown]; Region: COG2149 336982006353 Domain of unknown function (DUF202); Region: DUF202; pfam02656 336982006354 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 336982006355 Cytochrome P450; Region: p450; cl12078 336982006356 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial protein Rv2277c and similar proteins; Region: GDPD_Rv2277c_like; cd08580 336982006357 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 336982006358 putative active site [active] 336982006359 catalytic site [active] 336982006360 putative metal binding site [ion binding]; other site 336982006361 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 336982006362 FAD binding domain; Region: FAD_binding_4; pfam01565 336982006363 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 336982006364 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 336982006365 Transcriptional regulator [Transcription]; Region: LysR; COG0583 336982006366 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 336982006367 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 336982006368 dimerization interface [polypeptide binding]; other site 336982006369 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 336982006370 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 336982006371 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 336982006372 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 336982006373 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 336982006374 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 336982006375 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 336982006376 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 336982006377 CDP-diacylglycerol pyrophosphatase cdh; Mapped to H37Rv Rv2289 336982006378 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 336982006379 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 336982006380 active site residue [active] 336982006381 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 336982006382 active site residue [active] 336982006383 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 336982006384 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 336982006385 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 336982006386 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 336982006387 pyridoxal 5'-phosphate binding site [chemical binding]; other site 336982006388 homodimer interface [polypeptide binding]; other site 336982006389 catalytic residue [active] 336982006390 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3196 336982006391 haloalkane dehalogenase; Provisional; Region: PRK00870 336982006392 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 336982006393 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 336982006394 active site 336982006395 catalytic tetrad [active] 336982006396 heat shock protein 90; Provisional; Region: PRK05218 336982006397 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 336982006398 ATP binding site [chemical binding]; other site 336982006399 Mg2+ binding site [ion binding]; other site 336982006400 G-X-G motif; other site 336982006401 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 336982006402 Cutinase; Region: Cutinase; pfam01083 336982006403 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 336982006404 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 336982006405 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 336982006406 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 336982006407 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 336982006408 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 336982006409 Uncharacterized conserved protein [Function unknown]; Region: COG2442 336982006410 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 336982006411 DNA binding site [nucleotide binding] 336982006412 active site 336982006413 Int/Topo IB signature motif; other site 336982006414 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 336982006415 DNA binding residues [nucleotide binding] 336982006416 Family description; Region: UvrD_C_2; pfam13538 336982006417 Uncharacterized conserved protein [Function unknown]; Region: COG2128 336982006418 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 336982006419 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 336982006420 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 336982006421 putative PBP binding loops; other site 336982006422 ABC-ATPase subunit interface; other site 336982006423 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 336982006424 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 336982006425 dimer interface [polypeptide binding]; other site 336982006426 conserved gate region; other site 336982006427 putative PBP binding loops; other site 336982006428 ABC-ATPase subunit interface; other site 336982006429 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 336982006430 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 336982006431 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 336982006432 Ligand Binding Site [chemical binding]; other site 336982006433 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 336982006434 Ligand Binding Site [chemical binding]; other site 336982006435 amino acid transporter; Region: 2A0306; TIGR00909 336982006436 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 336982006437 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 336982006438 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 336982006439 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 336982006440 catalytic residue [active] 336982006441 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 336982006442 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 336982006443 Amidinotransferase; Region: Amidinotransf; pfam02274 336982006444 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 336982006445 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 336982006446 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 336982006447 putative DNA binding site [nucleotide binding]; other site 336982006448 putative Zn2+ binding site [ion binding]; other site 336982006449 AsnC family; Region: AsnC_trans_reg; pfam01037 336982006450 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 336982006451 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 336982006452 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 336982006453 Walker A/P-loop; other site 336982006454 ATP binding site [chemical binding]; other site 336982006455 Q-loop/lid; other site 336982006456 ABC transporter signature motif; other site 336982006457 Walker B; other site 336982006458 D-loop; other site 336982006459 H-loop/switch region; other site 336982006460 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 336982006461 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 336982006462 Walker A/P-loop; other site 336982006463 ATP binding site [chemical binding]; other site 336982006464 Q-loop/lid; other site 336982006465 ABC transporter signature motif; other site 336982006466 Walker B; other site 336982006467 D-loop; other site 336982006468 H-loop/switch region; other site 336982006469 MarR family; Region: MarR; pfam01047 336982006470 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 336982006471 PE family; Region: PE; pfam00934 336982006472 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 336982006473 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 336982006474 putative substrate translocation pore; other site 336982006475 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 336982006476 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 336982006477 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 336982006478 malate dehydrogenase; Provisional; Region: PRK13529 336982006479 Malic enzyme, N-terminal domain; Region: malic; pfam00390 336982006480 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 336982006481 NAD(P) binding site [chemical binding]; other site 336982006482 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 336982006483 Major Facilitator Superfamily; Region: MFS_1; pfam07690 336982006484 putative substrate translocation pore; other site 336982006485 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 336982006486 putative substrate translocation pore; other site 336982006487 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 336982006488 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 336982006489 dimer interface [polypeptide binding]; other site 336982006490 pyridoxal 5'-phosphate binding site [chemical binding]; other site 336982006491 catalytic residue [active] 336982006492 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 336982006493 serine O-acetyltransferase; Region: cysE; TIGR01172 336982006494 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 336982006495 trimer interface [polypeptide binding]; other site 336982006496 active site 336982006497 substrate binding site [chemical binding]; other site 336982006498 CoA binding site [chemical binding]; other site 336982006499 hypothetical protein; Provisional; Region: PRK14851 336982006500 hypothetical protein; Validated; Region: PRK08223 336982006501 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 336982006502 ATP binding site [chemical binding]; other site 336982006503 substrate interface [chemical binding]; other site 336982006504 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 336982006505 PE family; Region: PE; pfam00934 336982006506 DNA primase; Validated; Region: dnaG; PRK05667 336982006507 CHC2 zinc finger; Region: zf-CHC2; pfam01807 336982006508 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 336982006509 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 336982006510 active site 336982006511 metal binding site [ion binding]; metal-binding site 336982006512 interdomain interaction site; other site 336982006513 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 336982006514 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 336982006515 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 336982006516 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 336982006517 Zn2+ binding site [ion binding]; other site 336982006518 Mg2+ binding site [ion binding]; other site 336982006519 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 336982006520 Repair protein; Region: Repair_PSII; pfam04536 336982006521 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 336982006522 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 336982006523 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 336982006524 Phosphoesterase family; Region: Phosphoesterase; pfam04185 336982006525 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 336982006526 Phosphoesterase family; Region: Phosphoesterase; pfam04185 336982006527 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 336982006528 Phosphoesterase family; Region: Phosphoesterase; pfam04185 336982006529 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982006530 PPE family; Region: PPE; pfam00823 336982006531 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 336982006532 Transposase; Region: HTH_Tnp_1; cl17663 336982006533 putative transposase OrfB; Reviewed; Region: PHA02517 336982006534 HTH-like domain; Region: HTH_21; pfam13276 336982006535 Integrase core domain; Region: rve; pfam00665 336982006536 Integrase core domain; Region: rve_3; pfam13683 336982006537 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982006538 PPE family; Region: PPE; pfam00823 336982006539 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 336982006540 Transposase; Region: HTH_Tnp_1; cl17663 336982006541 putative transposase OrfB; Reviewed; Region: PHA02517 336982006542 HTH-like domain; Region: HTH_21; pfam13276 336982006543 Integrase core domain; Region: rve; pfam00665 336982006544 Integrase core domain; Region: rve_3; pfam13683 336982006545 PPE family; Region: PPE; pfam00823 336982006546 PPE family; Region: PPE; pfam00823 336982006547 glycyl-tRNA synthetase; Provisional; Region: PRK04173 336982006548 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 336982006549 motif 1; other site 336982006550 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 336982006551 active site 336982006552 motif 2; other site 336982006553 motif 3; other site 336982006554 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 336982006555 anticodon binding site; other site 336982006556 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 336982006557 dimerization interface [polypeptide binding]; other site 336982006558 putative DNA binding site [nucleotide binding]; other site 336982006559 putative Zn2+ binding site [ion binding]; other site 336982006560 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 336982006561 metal binding site 2 [ion binding]; metal-binding site 336982006562 putative DNA binding helix; other site 336982006563 metal binding site 1 [ion binding]; metal-binding site 336982006564 dimer interface [polypeptide binding]; other site 336982006565 structural Zn2+ binding site [ion binding]; other site 336982006566 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 336982006567 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 336982006568 catalytic residue [active] 336982006569 putative FPP diphosphate binding site; other site 336982006570 putative FPP binding hydrophobic cleft; other site 336982006571 dimer interface [polypeptide binding]; other site 336982006572 putative IPP diphosphate binding site; other site 336982006573 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 336982006574 Recombination protein O N terminal; Region: RecO_N; pfam11967 336982006575 Recombination protein O C terminal; Region: RecO_C; pfam02565 336982006576 amidase; Provisional; Region: PRK06061 336982006577 Amidase; Region: Amidase; pfam01425 336982006578 GTPase Era; Reviewed; Region: era; PRK00089 336982006579 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 336982006580 G1 box; other site 336982006581 GTP/Mg2+ binding site [chemical binding]; other site 336982006582 Switch I region; other site 336982006583 G2 box; other site 336982006584 Switch II region; other site 336982006585 G3 box; other site 336982006586 G4 box; other site 336982006587 G5 box; other site 336982006588 KH domain; Region: KH_2; pfam07650 336982006589 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 336982006590 Domain of unknown function DUF21; Region: DUF21; pfam01595 336982006591 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 336982006592 Transporter associated domain; Region: CorC_HlyC; smart01091 336982006593 metal-binding heat shock protein; Provisional; Region: PRK00016 336982006594 K homology RNA-binding domain; Region: KH; smart00322 336982006595 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 336982006596 PhoH-like protein; Region: PhoH; pfam02562 336982006597 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 336982006598 PE family; Region: PE; pfam00934 336982006599 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 336982006600 RNA methyltransferase, RsmE family; Region: TIGR00046 336982006601 chaperone protein DnaJ; Provisional; Region: PRK14278 336982006602 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 336982006603 HSP70 interaction site [polypeptide binding]; other site 336982006604 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 336982006605 Zn binding sites [ion binding]; other site 336982006606 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 336982006607 dimer interface [polypeptide binding]; other site 336982006608 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 336982006609 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 336982006610 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 336982006611 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 336982006612 Condensation domain; Region: Condensation; pfam00668 336982006613 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 336982006614 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 336982006615 acyl-activating enzyme (AAE) consensus motif; other site 336982006616 AMP binding site [chemical binding]; other site 336982006617 Condensation domain; Region: Condensation; pfam00668 336982006618 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 336982006619 Condensation domain; Region: Condensation; pfam00668 336982006620 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 336982006621 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 336982006622 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 336982006623 acyl-activating enzyme (AAE) consensus motif; other site 336982006624 AMP binding site [chemical binding]; other site 336982006625 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 336982006626 Condensation domain; Region: Condensation; pfam00668 336982006627 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 336982006628 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 336982006629 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 336982006630 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 336982006631 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 336982006632 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 336982006633 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 336982006634 NADP binding site [chemical binding]; other site 336982006635 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 336982006636 active site 336982006637 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 336982006638 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 336982006639 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 336982006640 active site 336982006641 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 336982006642 Condensation domain; Region: Condensation; pfam00668 336982006643 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 336982006644 Nonribosomal peptide synthase; Region: NRPS; pfam08415 336982006645 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 336982006646 acyl-activating enzyme (AAE) consensus motif; other site 336982006647 AMP binding site [chemical binding]; other site 336982006648 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 336982006649 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 336982006650 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 336982006651 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 336982006652 acyl-activating enzyme (AAE) consensus motif; other site 336982006653 active site 336982006654 AMP binding site [chemical binding]; other site 336982006655 substrate binding site [chemical binding]; other site 336982006656 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 336982006657 salicylate synthase MbtI; Reviewed; Region: PRK07912 336982006658 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 336982006659 Predicted permease [General function prediction only]; Region: COG3329 336982006660 coproporphyrinogen III oxidase; Validated; Region: PRK05628 336982006661 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 336982006662 conserved hypothetical protein; Mapped to H37Rv Rv2390c; interrupted by transposases 336982006663 putative transposase OrfB; Reviewed; Region: PHA02517 336982006664 HTH-like domain; Region: HTH_21; pfam13276 336982006665 Integrase core domain; Region: rve; pfam00665 336982006666 Integrase core domain; Region: rve_3; pfam13683 336982006667 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 336982006668 Transposase; Region: HTH_Tnp_1; cl17663 336982006669 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 336982006670 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 336982006671 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 336982006672 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 336982006673 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 336982006674 Active Sites [active] 336982006675 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 336982006676 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 336982006677 putative active site [active] 336982006678 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 336982006679 putative active site [active] 336982006680 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 336982006681 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 336982006682 Predicted membrane protein [Function unknown]; Region: COG1297 336982006683 putative oligopeptide transporter, OPT family; Region: TIGR00733 336982006684 PE family; Region: PE; pfam00934 336982006685 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 336982006686 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 336982006687 Walker A/P-loop; other site 336982006688 ATP binding site [chemical binding]; other site 336982006689 Q-loop/lid; other site 336982006690 ABC transporter signature motif; other site 336982006691 Walker B; other site 336982006692 D-loop; other site 336982006693 H-loop/switch region; other site 336982006694 sulfate transport protein; Provisional; Region: cysT; CHL00187 336982006695 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 336982006696 dimer interface [polypeptide binding]; other site 336982006697 conserved gate region; other site 336982006698 putative PBP binding loops; other site 336982006699 ABC-ATPase subunit interface; other site 336982006700 sulfate transport protein; Provisional; Region: cysT; CHL00187 336982006701 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 336982006702 dimer interface [polypeptide binding]; other site 336982006703 conserved gate region; other site 336982006704 putative PBP binding loops; other site 336982006705 ABC-ATPase subunit interface; other site 336982006706 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 336982006707 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 336982006708 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 336982006709 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 336982006710 PknH-like extracellular domain; Region: PknH_C; pfam14032 336982006711 GTP-binding protein LepA; Provisional; Region: PRK05433 336982006712 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 336982006713 G1 box; other site 336982006714 putative GEF interaction site [polypeptide binding]; other site 336982006715 GTP/Mg2+ binding site [chemical binding]; other site 336982006716 Switch I region; other site 336982006717 G2 box; other site 336982006718 G3 box; other site 336982006719 Switch II region; other site 336982006720 G4 box; other site 336982006721 G5 box; other site 336982006722 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 336982006723 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 336982006724 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 336982006725 PemK-like protein; Region: PemK; pfam02452 336982006726 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 336982006727 FOG: CBS domain [General function prediction only]; Region: COG0517 336982006728 ribonuclease Z; Reviewed; Region: PRK00055 336982006729 PE family; Region: PE; pfam00934 336982006730 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 336982006731 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 336982006732 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 336982006733 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 336982006734 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 336982006735 Uncharacterized conserved protein [Function unknown]; Region: COG2308 336982006736 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 336982006737 hypothetical protein; Reviewed; Region: PRK07914 336982006738 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 336982006739 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 336982006740 Competence protein; Region: Competence; pfam03772 336982006741 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 336982006742 Helix-hairpin-helix motif; Region: HHH; pfam00633 336982006743 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 336982006744 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 336982006745 Coenzyme A binding pocket [chemical binding]; other site 336982006746 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 336982006747 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 336982006748 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 336982006749 active site 336982006750 catalytic triad [active] 336982006751 oxyanion hole [active] 336982006752 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 336982006753 catalytic core [active] 336982006754 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 336982006755 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 336982006756 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 336982006757 active site 336982006758 (T/H)XGH motif; other site 336982006759 Methyltransferase domain; Region: Methyltransf_23; pfam13489 336982006760 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 336982006761 S-adenosylmethionine binding site [chemical binding]; other site 336982006762 Transposase; Region: DEDD_Tnp_IS110; pfam01548 336982006763 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 336982006764 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 336982006765 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 336982006766 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 336982006767 metal ion-dependent adhesion site (MIDAS); other site 336982006768 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 336982006769 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 336982006770 Walker A motif; other site 336982006771 ATP binding site [chemical binding]; other site 336982006772 Walker B motif; other site 336982006773 arginine finger; other site 336982006774 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 336982006775 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 336982006776 putative catalytic cysteine [active] 336982006777 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 336982006778 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 336982006779 dimer interface [polypeptide binding]; other site 336982006780 decamer (pentamer of dimers) interface [polypeptide binding]; other site 336982006781 catalytic triad [active] 336982006782 peroxidatic and resolving cysteines [active] 336982006783 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 336982006784 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 336982006785 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982006786 PPE family; Region: PPE; pfam00823 336982006787 PE family; Region: PE; pfam00934 336982006788 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 336982006789 Mechanosensitive ion channel; Region: MS_channel; pfam00924 336982006790 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 336982006791 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 336982006792 ligand binding site [chemical binding]; other site 336982006793 flexible hinge region; other site 336982006794 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 336982006795 dimerization interface [polypeptide binding]; other site 336982006796 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 336982006797 cyclase homology domain; Region: CHD; cd07302 336982006798 nucleotidyl binding site; other site 336982006799 metal binding site [ion binding]; metal-binding site 336982006800 dimer interface [polypeptide binding]; other site 336982006801 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 336982006802 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 336982006803 substrate binding site [chemical binding]; other site 336982006804 dimer interface [polypeptide binding]; other site 336982006805 ATP binding site [chemical binding]; other site 336982006806 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 336982006807 NAD synthetase; Reviewed; Region: nadE; PRK02628 336982006808 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 336982006809 multimer interface [polypeptide binding]; other site 336982006810 active site 336982006811 catalytic triad [active] 336982006812 protein interface 1 [polypeptide binding]; other site 336982006813 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 336982006814 homodimer interface [polypeptide binding]; other site 336982006815 NAD binding pocket [chemical binding]; other site 336982006816 ATP binding pocket [chemical binding]; other site 336982006817 Mg binding site [ion binding]; other site 336982006818 active-site loop [active] 336982006819 gamma-glutamyl kinase; Provisional; Region: PRK05429 336982006820 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 336982006821 nucleotide binding site [chemical binding]; other site 336982006822 homotetrameric interface [polypeptide binding]; other site 336982006823 putative phosphate binding site [ion binding]; other site 336982006824 putative allosteric binding site; other site 336982006825 PUA domain; Region: PUA; pfam01472 336982006826 GTPase CgtA; Reviewed; Region: obgE; PRK12296 336982006827 GTP1/OBG; Region: GTP1_OBG; pfam01018 336982006828 Obg GTPase; Region: Obg; cd01898 336982006829 G1 box; other site 336982006830 GTP/Mg2+ binding site [chemical binding]; other site 336982006831 Switch I region; other site 336982006832 G2 box; other site 336982006833 G3 box; other site 336982006834 Switch II region; other site 336982006835 G4 box; other site 336982006836 G5 box; other site 336982006837 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 336982006838 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 336982006839 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 336982006840 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 336982006841 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 336982006842 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 336982006843 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 336982006844 homodimer interface [polypeptide binding]; other site 336982006845 oligonucleotide binding site [chemical binding]; other site 336982006846 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 336982006847 active site 336982006848 multimer interface [polypeptide binding]; other site 336982006849 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 336982006850 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 336982006851 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 336982006852 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 336982006853 active site 336982006854 HIGH motif; other site 336982006855 nucleotide binding site [chemical binding]; other site 336982006856 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 336982006857 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 336982006858 active site 336982006859 KMSKS motif; other site 336982006860 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 336982006861 tRNA binding surface [nucleotide binding]; other site 336982006862 anticodon binding site; other site 336982006863 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 336982006864 Uncharacterized conserved protein [Function unknown]; Region: COG3268 336982006865 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 336982006866 NAD(P) binding pocket [chemical binding]; other site 336982006867 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 336982006868 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 336982006869 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 336982006870 GTP binding site; other site 336982006871 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 336982006872 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 336982006873 TPP-binding site [chemical binding]; other site 336982006874 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 336982006875 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 336982006876 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 336982006877 dimer interface [polypeptide binding]; other site 336982006878 PYR/PP interface [polypeptide binding]; other site 336982006879 TPP binding site [chemical binding]; other site 336982006880 substrate binding site [chemical binding]; other site 336982006881 Major Facilitator Superfamily; Region: MFS_1; pfam07690 336982006882 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 336982006883 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 336982006884 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 336982006885 Walker A motif; other site 336982006886 ATP binding site [chemical binding]; other site 336982006887 Walker B motif; other site 336982006888 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 336982006889 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 336982006890 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 336982006891 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 336982006892 Major Facilitator Superfamily; Region: MFS_1; pfam07690 336982006893 putative substrate translocation pore; other site 336982006894 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 336982006895 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 336982006896 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 336982006897 oligomer interface [polypeptide binding]; other site 336982006898 active site residues [active] 336982006899 Clp protease; Region: CLP_protease; pfam00574 336982006900 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 336982006901 oligomer interface [polypeptide binding]; other site 336982006902 active site residues [active] 336982006903 trigger factor; Provisional; Region: tig; PRK01490 336982006904 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 336982006905 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 336982006906 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 336982006907 Beta-lactamase; Region: Beta-lactamase; pfam00144 336982006908 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 336982006909 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 336982006910 putative DNA binding site [nucleotide binding]; other site 336982006911 catalytic residue [active] 336982006912 putative H2TH interface [polypeptide binding]; other site 336982006913 putative catalytic residues [active] 336982006914 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 336982006915 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 336982006916 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 336982006917 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 336982006918 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 336982006919 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 336982006920 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 336982006921 Zn binding site [ion binding]; other site 336982006922 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 336982006923 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 336982006924 active site 336982006925 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 336982006926 apolar tunnel; other site 336982006927 heme binding site [chemical binding]; other site 336982006928 dimerization interface [polypeptide binding]; other site 336982006929 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 336982006930 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 336982006931 active site 336982006932 catalytic site [active] 336982006933 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 336982006934 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 336982006935 active site 336982006936 NAD-specific glutamate dehydrogenase [Amino acid transport and metabolism]; Region: COG2902 336982006937 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 336982006938 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 336982006939 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 336982006940 ABC transporter; Region: ABC_tran_2; pfam12848 336982006941 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 336982006942 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 336982006943 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 336982006944 dimer interface [polypeptide binding]; other site 336982006945 ssDNA binding site [nucleotide binding]; other site 336982006946 tetramer (dimer of dimers) interface [polypeptide binding]; other site 336982006947 glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355 336982006948 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 336982006949 putative acyl-acceptor binding pocket; other site 336982006950 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 336982006951 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 336982006952 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 336982006953 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 336982006954 putative acyl-acceptor binding pocket; other site 336982006955 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 336982006956 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 336982006957 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 336982006958 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 336982006959 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 336982006960 enoyl-CoA hydratase; Provisional; Region: PRK05870 336982006961 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 336982006962 substrate binding site [chemical binding]; other site 336982006963 oxyanion hole (OAH) forming residues; other site 336982006964 trimer interface [polypeptide binding]; other site 336982006965 PE family; Region: PE; pfam00934 336982006966 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 336982006967 cyclase homology domain; Region: CHD; cd07302 336982006968 nucleotidyl binding site; other site 336982006969 metal binding site [ion binding]; metal-binding site 336982006970 dimer interface [polypeptide binding]; other site 336982006971 Predicted ATPase [General function prediction only]; Region: COG3903 336982006972 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 336982006973 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 336982006974 DNA binding residues [nucleotide binding] 336982006975 dimerization interface [polypeptide binding]; other site 336982006976 PE family; Region: PE; pfam00934 336982006977 TIGR00725 family protein; Region: TIGR00725 336982006978 thymidylate synthase; Provisional; Region: thyA; PRK00956 336982006979 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 336982006980 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 336982006981 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 336982006982 E3 interaction surface; other site 336982006983 lipoyl attachment site [posttranslational modification]; other site 336982006984 e3 binding domain; Region: E3_binding; pfam02817 336982006985 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 336982006986 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 336982006987 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 336982006988 alpha subunit interface [polypeptide binding]; other site 336982006989 TPP binding site [chemical binding]; other site 336982006990 heterodimer interface [polypeptide binding]; other site 336982006991 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 336982006992 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 336982006993 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 336982006994 tetramer interface [polypeptide binding]; other site 336982006995 TPP-binding site [chemical binding]; other site 336982006996 heterodimer interface [polypeptide binding]; other site 336982006997 phosphorylation loop region [posttranslational modification] 336982006998 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 336982006999 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 336982007000 putative active site [active] 336982007001 putative catalytic site [active] 336982007002 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 336982007003 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 336982007004 active site 336982007005 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 336982007006 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 336982007007 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 336982007008 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 336982007009 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 336982007010 carboxyltransferase (CT) interaction site; other site 336982007011 biotinylation site [posttranslational modification]; other site 336982007012 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 336982007013 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 336982007014 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 336982007015 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 336982007016 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 336982007017 AMP-binding domain protein; Validated; Region: PRK08315 336982007018 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 336982007019 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 336982007020 acyl-activating enzyme (AAE) consensus motif; other site 336982007021 acyl-activating enzyme (AAE) consensus motif; other site 336982007022 putative AMP binding site [chemical binding]; other site 336982007023 putative active site [active] 336982007024 putative CoA binding site [chemical binding]; other site 336982007025 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982007026 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982007027 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 336982007028 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 336982007029 classical (c) SDRs; Region: SDR_c; cd05233 336982007030 NAD(P) binding site [chemical binding]; other site 336982007031 active site 336982007032 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 336982007033 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 336982007034 catalytic site [active] 336982007035 putative active site [active] 336982007036 putative substrate binding site [chemical binding]; other site 336982007037 dimer interface [polypeptide binding]; other site 336982007038 Transposase, Mutator family; Region: Transposase_mut; pfam00872 336982007039 MULE transposase domain; Region: MULE; pfam10551 336982007040 Domain of unknown function (DUF4411); Region: DUF4411; pfam14367 336982007041 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 336982007042 non-specific DNA binding site [nucleotide binding]; other site 336982007043 salt bridge; other site 336982007044 sequence-specific DNA binding site [nucleotide binding]; other site 336982007045 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 336982007046 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893 336982007047 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 336982007048 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 336982007049 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 336982007050 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 336982007051 PE family; Region: PE; pfam00934 336982007052 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 336982007053 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 336982007054 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 336982007055 catalytic triad [active] 336982007056 hypothetical protein; Provisional; Region: PRK07907 336982007057 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 336982007058 active site 336982007059 metal binding site [ion binding]; metal-binding site 336982007060 dimer interface [polypeptide binding]; other site 336982007061 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 336982007062 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 336982007063 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 336982007064 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 336982007065 phosphate binding site [ion binding]; other site 336982007066 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 336982007067 FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447 336982007068 putative active site [active] 336982007069 putative catalytic site [active] 336982007070 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 336982007071 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 336982007072 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 336982007073 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 336982007074 putative NAD(P) binding site [chemical binding]; other site 336982007075 active site 336982007076 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 336982007077 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 336982007078 active site 336982007079 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 336982007080 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 336982007081 putative active site [active] 336982007082 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 336982007083 Mrr N-terminal domain; Region: Mrr_N; pfam14338 336982007084 Restriction endonuclease; Region: Mrr_cat; pfam04471 336982007085 ERCC4 domain; Region: ERCC4; pfam02732 336982007086 Lsr2; Region: Lsr2; pfam11774 336982007087 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 336982007088 putative active site [active] 336982007089 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 336982007090 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 336982007091 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 336982007092 catalytic residue [active] 336982007093 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 336982007094 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 336982007095 putative RNA binding site [nucleotide binding]; other site 336982007096 elongation factor P; Validated; Region: PRK00529 336982007097 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 336982007098 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 336982007099 RNA binding site [nucleotide binding]; other site 336982007100 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 336982007101 RNA binding site [nucleotide binding]; other site 336982007102 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 336982007103 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 336982007104 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 336982007105 active site 336982007106 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 336982007107 Dehydroquinase class II; Region: DHquinase_II; pfam01220 336982007108 trimer interface [polypeptide binding]; other site 336982007109 active site 336982007110 dimer interface [polypeptide binding]; other site 336982007111 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 336982007112 active site 336982007113 dimer interface [polypeptide binding]; other site 336982007114 metal binding site [ion binding]; metal-binding site 336982007115 shikimate kinase; Reviewed; Region: aroK; PRK00131 336982007116 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 336982007117 ADP binding site [chemical binding]; other site 336982007118 magnesium binding site [ion binding]; other site 336982007119 putative shikimate binding site; other site 336982007120 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 336982007121 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 336982007122 Tetramer interface [polypeptide binding]; other site 336982007123 active site 336982007124 FMN-binding site [chemical binding]; other site 336982007125 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 336982007126 digalactosyldiacylglycerol synthase; Region: PLN02846 336982007127 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 336982007128 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 336982007129 putative active site [active] 336982007130 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 336982007131 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 336982007132 oligomeric interface; other site 336982007133 putative active site [active] 336982007134 homodimer interface [polypeptide binding]; other site 336982007135 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402 336982007136 putative active site [active] 336982007137 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 336982007138 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 336982007139 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 336982007140 shikimate-5-dehydrogenase, fungal AROM-type; Region: Shik-DH-AROM; TIGR01809 336982007141 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 336982007142 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 336982007143 NAD(P) binding site [chemical binding]; other site 336982007144 shikimate binding site; other site 336982007145 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 336982007146 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 336982007147 dimerization interface [polypeptide binding]; other site 336982007148 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 336982007149 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 336982007150 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 336982007151 motif 1; other site 336982007152 active site 336982007153 motif 2; other site 336982007154 motif 3; other site 336982007155 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 336982007156 DHHA1 domain; Region: DHHA1; pfam02272 336982007157 Uncharacterized conserved protein [Function unknown]; Region: COG0432 336982007158 recombination factor protein RarA; Reviewed; Region: PRK13342 336982007159 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 336982007160 Walker A motif; other site 336982007161 ATP binding site [chemical binding]; other site 336982007162 Walker B motif; other site 336982007163 arginine finger; other site 336982007164 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 336982007165 Predicted integral membrane protein [Function unknown]; Region: COG5473 336982007166 Protein of unknown function (DUF2652); Region: DUF2652; pfam10851 336982007167 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 336982007168 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 336982007169 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 336982007170 Walker A/P-loop; other site 336982007171 ATP binding site [chemical binding]; other site 336982007172 Q-loop/lid; other site 336982007173 ABC transporter signature motif; other site 336982007174 Walker B; other site 336982007175 D-loop; other site 336982007176 H-loop/switch region; other site 336982007177 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 336982007178 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 336982007179 ligand binding site [chemical binding]; other site 336982007180 flexible hinge region; other site 336982007181 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 336982007182 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 336982007183 ligand binding site [chemical binding]; other site 336982007184 flexible hinge region; other site 336982007185 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 336982007186 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 336982007187 active site 336982007188 nucleophile elbow; other site 336982007189 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 336982007190 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 336982007191 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 336982007192 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 336982007193 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 336982007194 Uncharacterized conserved protein [Function unknown]; Region: COG2308 336982007195 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 336982007196 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 336982007197 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 336982007198 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 336982007199 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 336982007200 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 336982007201 Transglutaminase/protease-like homologues; Region: TGc; smart00460 336982007202 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3801 336982007203 Predicted membrane protein [Function unknown]; Region: COG4129 336982007204 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 336982007205 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 336982007206 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 336982007207 dimer interface [polypeptide binding]; other site 336982007208 anticodon binding site; other site 336982007209 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 336982007210 homodimer interface [polypeptide binding]; other site 336982007211 motif 1; other site 336982007212 active site 336982007213 motif 2; other site 336982007214 GAD domain; Region: GAD; pfam02938 336982007215 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 336982007216 active site 336982007217 motif 3; other site 336982007218 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 336982007219 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 336982007220 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 336982007221 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 336982007222 putative hydrophobic ligand binding site [chemical binding]; other site 336982007223 protein interface [polypeptide binding]; other site 336982007224 gate; other site 336982007225 Predicted metalloprotease [General function prediction only]; Region: COG2321 336982007226 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 336982007227 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 336982007228 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 336982007229 active site 336982007230 metal binding site [ion binding]; metal-binding site 336982007231 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 336982007232 haloalkane dehalogenase; Provisional; Region: PRK03592 336982007233 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 336982007234 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 336982007235 dimer interface [polypeptide binding]; other site 336982007236 motif 1; other site 336982007237 active site 336982007238 motif 2; other site 336982007239 motif 3; other site 336982007240 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 336982007241 anticodon binding site; other site 336982007242 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 336982007243 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 336982007244 active site 336982007245 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 336982007246 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 336982007247 Zn2+ binding site [ion binding]; other site 336982007248 Mg2+ binding site [ion binding]; other site 336982007249 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 336982007250 synthetase active site [active] 336982007251 NTP binding site [chemical binding]; other site 336982007252 metal binding site [ion binding]; metal-binding site 336982007253 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 336982007254 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 336982007255 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 336982007256 active site 336982007257 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 336982007258 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 336982007259 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 336982007260 Protein export membrane protein; Region: SecD_SecF; pfam02355 336982007261 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 336982007262 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 336982007263 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05886 336982007264 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 336982007265 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 336982007266 inhibitor-cofactor binding pocket; inhibition site 336982007267 pyridoxal 5'-phosphate binding site [chemical binding]; other site 336982007268 catalytic residue [active] 336982007269 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 336982007270 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 336982007271 acyl-activating enzyme (AAE) consensus motif; other site 336982007272 AMP binding site [chemical binding]; other site 336982007273 active site 336982007274 CoA binding site [chemical binding]; other site 336982007275 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 336982007276 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 336982007277 putative NAD(P) binding site [chemical binding]; other site 336982007278 active site 336982007279 putative substrate binding site [chemical binding]; other site 336982007280 PE family; Region: PE; pfam00934 336982007281 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 336982007282 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 336982007283 Walker A motif; other site 336982007284 ATP binding site [chemical binding]; other site 336982007285 Walker B motif; other site 336982007286 arginine finger; other site 336982007287 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 336982007288 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 336982007289 RuvA N terminal domain; Region: RuvA_N; pfam01330 336982007290 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 336982007291 active site 336982007292 putative DNA-binding cleft [nucleotide binding]; other site 336982007293 dimer interface [polypeptide binding]; other site 336982007294 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 336982007295 putative active site [active] 336982007296 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 336982007297 Protein of unknown function DUF2617; Region: DUF2617; pfam10936 336982007298 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 336982007299 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 336982007300 Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only]; Region: COG4262 336982007301 Spermine/spermidine synthase; Region: Spermine_synth; pfam01564 336982007302 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 336982007303 hypothetical protein; Validated; Region: PRK00110 336982007304 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 336982007305 predicted active site [active] 336982007306 catalytic triad [active] 336982007307 acyl-CoA thioesterase II; Region: tesB; TIGR00189 336982007308 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 336982007309 active site 336982007310 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 336982007311 catalytic triad [active] 336982007312 dimer interface [polypeptide binding]; other site 336982007313 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 336982007314 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 336982007315 active site 336982007316 multimer interface [polypeptide binding]; other site 336982007317 Pyridoxamine-phosphate oxidase [Coenzyme metabolism]; Region: PdxH; COG0259 336982007318 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 336982007319 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 336982007320 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982007321 PPE family; Region: PPE; pfam00823 336982007322 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982007323 PE-PPE domain; Region: PE-PPE; pfam08237 336982007324 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 336982007325 nudix motif; other site 336982007326 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 336982007327 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 336982007328 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 336982007329 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 336982007330 putative acyl-acceptor binding pocket; other site 336982007331 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 336982007332 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 336982007333 nucleotide binding site/active site [active] 336982007334 HIT family signature motif; other site 336982007335 catalytic residue [active] 336982007336 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 336982007337 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 336982007338 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 336982007339 active site 336982007340 dimer interface [polypeptide binding]; other site 336982007341 motif 1; other site 336982007342 motif 2; other site 336982007343 motif 3; other site 336982007344 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 336982007345 anticodon binding site; other site 336982007346 PE family; Region: PE; pfam00934 336982007347 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4762 336982007348 Helix-turn-helix domain; Region: HTH_20; pfam12840 336982007349 Predicted transcriptional regulator [Transcription]; Region: COG2345 336982007350 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 336982007351 Predicted transcriptional regulator [Transcription]; Region: COG2345 336982007352 Helix-turn-helix domain; Region: HTH_20; pfam12840 336982007353 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 336982007354 S-adenosylmethionine binding site [chemical binding]; other site 336982007355 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 336982007356 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 336982007357 Ligand Binding Site [chemical binding]; other site 336982007358 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 336982007359 Ligand Binding Site [chemical binding]; other site 336982007360 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 336982007361 Ligand Binding Site [chemical binding]; other site 336982007362 Universal stress protein family; Region: Usp; pfam00582 336982007363 Ligand Binding Site [chemical binding]; other site 336982007364 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 336982007365 active site 336982007366 Peptidase family M50; Region: Peptidase_M50; pfam02163 336982007367 putative substrate binding region [chemical binding]; other site 336982007368 FOG: CBS domain [General function prediction only]; Region: COG0517 336982007369 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 336982007370 FOG: CBS domain [General function prediction only]; Region: COG0517 336982007371 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 336982007372 peptide chain release factor 1; Provisional; Region: PRK04011 336982007373 SHS2 domain protein implicated in nucleic acid metabolism [General function prediction only]; Region: COG1371 336982007374 Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690 336982007375 hypothetical protein; Reviewed; Region: PRK09588 336982007376 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 336982007377 Hemerythrin-like domain; Region: Hr-like; cd12108 336982007378 Fe binding site [ion binding]; other site 336982007379 PE family; Region: PE; pfam00934 336982007380 Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cd00227 336982007381 P-loop motif; other site 336982007382 ATP binding site [chemical binding]; other site 336982007383 Chloramphenicol (Cm) binding site [chemical binding]; other site 336982007384 catalytic residue [active] 336982007385 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 336982007386 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 336982007387 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 336982007388 anti sigma factor interaction site; other site 336982007389 regulatory phosphorylation site [posttranslational modification]; other site 336982007390 hypothetical protein; Provisional; Region: PRK02237 336982007391 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 336982007392 Transcriptional regulators [Transcription]; Region: MarR; COG1846 336982007393 putative DNA binding site [nucleotide binding]; other site 336982007394 putative Zn2+ binding site [ion binding]; other site 336982007395 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 336982007396 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 336982007397 putative metal binding site [ion binding]; other site 336982007398 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 336982007399 dimerization interface [polypeptide binding]; other site 336982007400 putative DNA binding site [nucleotide binding]; other site 336982007401 putative Zn2+ binding site [ion binding]; other site 336982007402 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 336982007403 arsenical-resistance protein; Region: acr3; TIGR00832 336982007404 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 336982007405 Low molecular weight phosphatase family; Region: LMWPc; cd00115 336982007406 active site 336982007407 Protein of unknown function (DUF3018); Region: DUF3018; pfam11455 336982007408 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 336982007409 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 336982007410 active site 336982007411 DNA binding site [nucleotide binding] 336982007412 Int/Topo IB signature motif; other site 336982007413 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 336982007414 ParB-like nuclease domain; Region: ParBc; cl02129 336982007415 Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653 336982007416 Phage capsid family; Region: Phage_capsid; pfam05065 336982007417 Phage head maturation protease [General function prediction only]; Region: COG3740 336982007418 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: COG3747 336982007419 Protein of unknown function (DUF3631); Region: DUF3631; pfam12307 336982007420 Protein of unknown function (DUF2742); Region: DUF2742; pfam10888 336982007421 DNA binding domain, excisionase family; Region: excise; TIGR01764 336982007422 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 336982007423 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 336982007424 active site 336982007425 catalytic residues [active] 336982007426 DNA binding site [nucleotide binding] 336982007427 Int/Topo IB signature motif; other site 336982007428 Transposase, Mutator family; Region: Transposase_mut; pfam00872 336982007429 MULE transposase domain; Region: MULE; pfam10551 336982007430 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 336982007431 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 336982007432 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 336982007433 Coenzyme A binding pocket [chemical binding]; other site 336982007434 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 336982007435 hypothetical protein; Provisional; Region: PRK14059 336982007436 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 336982007437 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 336982007438 TAP-like protein; Region: Abhydrolase_4; pfam08386 336982007439 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 336982007440 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 336982007441 SelR domain; Region: SelR; pfam01641 336982007442 Methyltransferase domain; Region: Methyltransf_31; pfam13847 336982007443 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 336982007444 S-adenosylmethionine binding site [chemical binding]; other site 336982007445 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 336982007446 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 336982007447 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 336982007448 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 336982007449 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 336982007450 substrate binding site [chemical binding]; other site 336982007451 active site 336982007452 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 336982007453 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 336982007454 substrate binding site [chemical binding]; other site 336982007455 oxyanion hole (OAH) forming residues; other site 336982007456 trimer interface [polypeptide binding]; other site 336982007457 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 336982007458 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 336982007459 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 336982007460 catalytic site [active] 336982007461 putative active site [active] 336982007462 putative substrate binding site [chemical binding]; other site 336982007463 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 336982007464 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 336982007465 TPP-binding site; other site 336982007466 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 336982007467 PYR/PP interface [polypeptide binding]; other site 336982007468 dimer interface [polypeptide binding]; other site 336982007469 TPP binding site [chemical binding]; other site 336982007470 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 336982007471 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 336982007472 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 336982007473 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 336982007474 transmembrane helices; other site 336982007475 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 336982007476 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 336982007477 transmembrane helices; other site 336982007478 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 336982007479 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 336982007480 Walker A/P-loop; other site 336982007481 ATP binding site [chemical binding]; other site 336982007482 Q-loop/lid; other site 336982007483 ABC transporter signature motif; other site 336982007484 Walker B; other site 336982007485 D-loop; other site 336982007486 H-loop/switch region; other site 336982007487 TRAM domain; Region: TRAM; cl01282 336982007488 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 336982007489 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 336982007490 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 336982007491 TrkA-N domain; Region: TrkA_N; pfam02254 336982007492 TrkA-C domain; Region: TrkA_C; pfam02080 336982007493 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 336982007494 TrkA-N domain; Region: TrkA_N; pfam02254 336982007495 TrkA-C domain; Region: TrkA_C; pfam02080 336982007496 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 336982007497 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 336982007498 generic binding surface II; other site 336982007499 ssDNA binding site; other site 336982007500 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 336982007501 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 336982007502 trimer interface [polypeptide binding]; other site 336982007503 active site 336982007504 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 336982007505 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 336982007506 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 336982007507 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 336982007508 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 336982007509 active site 336982007510 dimerization interface [polypeptide binding]; other site 336982007511 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 336982007512 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 336982007513 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 336982007514 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 336982007515 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 336982007516 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 336982007517 DNA binding residues [nucleotide binding] 336982007518 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 336982007519 homotrimer interaction site [polypeptide binding]; other site 336982007520 putative active site [active] 336982007521 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502 336982007522 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 336982007523 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 336982007524 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 336982007525 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 336982007526 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 336982007527 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 336982007528 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 336982007529 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 336982007530 DNA binding residues [nucleotide binding] 336982007531 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 336982007532 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 336982007533 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 336982007534 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 336982007535 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 336982007536 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 336982007537 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 336982007538 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 336982007539 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 336982007540 PAC2 family; Region: PAC2; pfam09754 336982007541 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 336982007542 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 336982007543 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 336982007544 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 336982007545 heme-binding site [chemical binding]; other site 336982007546 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 336982007547 ATP cone domain; Region: ATP-cone; pfam03477 336982007548 LysM domain; Region: LysM; pfam01476 336982007549 LexA repressor; Validated; Region: PRK00215 336982007550 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 336982007551 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 336982007552 Catalytic site [active] 336982007553 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 336982007554 LGFP repeat; Region: LGFP; pfam08310 336982007555 LGFP repeat; Region: LGFP; pfam08310 336982007556 LGFP repeat; Region: LGFP; pfam08310 336982007557 LGFP repeat; Region: LGFP; pfam08310 336982007558 LGFP repeat; Region: LGFP; pfam08310 336982007559 Integral membrane protein TerC family; Region: TerC; cl10468 336982007560 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 336982007561 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 336982007562 active site 336982007563 GTPases [General function prediction only]; Region: HflX; COG2262 336982007564 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 336982007565 HflX GTPase family; Region: HflX; cd01878 336982007566 G1 box; other site 336982007567 GTP/Mg2+ binding site [chemical binding]; other site 336982007568 Switch I region; other site 336982007569 G2 box; other site 336982007570 G3 box; other site 336982007571 Switch II region; other site 336982007572 G4 box; other site 336982007573 G5 box; other site 336982007574 diaminopimelate epimerase; Region: DapF; TIGR00652 336982007575 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 336982007576 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 336982007577 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 336982007578 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 336982007579 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 336982007580 active site 336982007581 metal binding site [ion binding]; metal-binding site 336982007582 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 336982007583 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 336982007584 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 336982007585 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 336982007586 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 336982007587 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 336982007588 FeS/SAM binding site; other site 336982007589 TRAM domain; Region: TRAM; cl01282 336982007590 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 336982007591 FeS/SAM binding site; other site 336982007592 Uncharacterized protein conserved in bacteria [General function prediction only]; Region: OraA; COG2137 336982007593 DNA recombination protein RecA; Reviewed; Region: recA; PRK09519 336982007594 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 336982007595 hexamer interface [polypeptide binding]; other site 336982007596 Walker A motif; other site 336982007597 ATP binding site [chemical binding]; other site 336982007598 Walker B motif; other site 336982007599 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 336982007600 protein-splicing catalytic site; other site 336982007601 thioester formation/cholesterol transfer; other site 336982007602 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 336982007603 recA bacterial DNA recombination protein; Region: RecA; cl17211 336982007604 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 336982007605 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 336982007606 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 336982007607 Limonene-1,2-epoxide hydrolase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LimA; COG4308 336982007608 PE family; Region: PE; pfam00934 336982007609 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 336982007610 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 336982007611 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 336982007612 non-specific DNA binding site [nucleotide binding]; other site 336982007613 salt bridge; other site 336982007614 sequence-specific DNA binding site [nucleotide binding]; other site 336982007615 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 336982007616 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 336982007617 Coenzyme A binding pocket [chemical binding]; other site 336982007618 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 336982007619 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 336982007620 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 336982007621 Uncharacterized conserved protein [Function unknown]; Region: COG1359 336982007622 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 336982007623 classical (c) SDRs; Region: SDR_c; cd05233 336982007624 NAD(P) binding site [chemical binding]; other site 336982007625 active site 336982007626 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 336982007627 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 336982007628 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 336982007629 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 336982007630 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 336982007631 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 336982007632 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 336982007633 dimer interface [polypeptide binding]; other site 336982007634 active site 336982007635 catalytic residue [active] 336982007636 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 336982007637 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 336982007638 HsdM N-terminal domain; Region: HsdM_N; pfam12161 336982007639 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 336982007640 Methyltransferase domain; Region: Methyltransf_26; pfam13659 336982007641 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 336982007642 putative active site [active] 336982007643 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 336982007644 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 336982007645 putative active site [active] 336982007646 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 336982007647 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 336982007648 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 336982007649 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 336982007650 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 336982007651 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 336982007652 folate binding site [chemical binding]; other site 336982007653 NADP+ binding site [chemical binding]; other site 336982007654 thymidylate synthase; Reviewed; Region: thyA; PRK01827 336982007655 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 336982007656 dimerization interface [polypeptide binding]; other site 336982007657 active site 336982007658 Dienelactone hydrolase family; Region: DLH; pfam01738 336982007659 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 336982007660 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 336982007661 classical (c) SDRs; Region: SDR_c; cd05233 336982007662 NAD(P) binding site [chemical binding]; other site 336982007663 active site 336982007664 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982007665 PPE family; Region: PPE; pfam00823 336982007666 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 336982007667 PE family; Region: PE; pfam00934 336982007668 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 336982007669 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982007670 PPE family; Region: PPE; pfam00823 336982007671 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 336982007672 dihydrodipicolinate reductase; Provisional; Region: PRK00048 336982007673 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 336982007674 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 336982007675 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 336982007676 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 336982007677 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 336982007678 Coenzyme A binding pocket [chemical binding]; other site 336982007679 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 336982007680 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 336982007681 FMN-binding pocket [chemical binding]; other site 336982007682 flavin binding motif; other site 336982007683 phosphate binding motif [ion binding]; other site 336982007684 beta-alpha-beta structure motif; other site 336982007685 NAD binding pocket [chemical binding]; other site 336982007686 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 336982007687 catalytic loop [active] 336982007688 iron binding site [ion binding]; other site 336982007689 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 336982007690 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 336982007691 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 336982007692 hydrophobic ligand binding site; other site 336982007693 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 336982007694 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 336982007695 putative DNA binding site [nucleotide binding]; other site 336982007696 putative Zn2+ binding site [ion binding]; other site 336982007697 AsnC family; Region: AsnC_trans_reg; pfam01037 336982007698 alanine dehydrogenase; Region: alaDH; TIGR00518 336982007699 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 336982007700 hexamer interface [polypeptide binding]; other site 336982007701 ligand binding site [chemical binding]; other site 336982007702 putative active site [active] 336982007703 NAD(P) binding site [chemical binding]; other site 336982007704 Nitronate monooxygenase; Region: NMO; pfam03060 336982007705 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 336982007706 FMN binding site [chemical binding]; other site 336982007707 substrate binding site [chemical binding]; other site 336982007708 putative catalytic residue [active] 336982007709 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 336982007710 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 336982007711 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 336982007712 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 336982007713 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 336982007714 oligomer interface [polypeptide binding]; other site 336982007715 RNA binding site [nucleotide binding]; other site 336982007716 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 336982007717 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 336982007718 RNase E interface [polypeptide binding]; other site 336982007719 trimer interface [polypeptide binding]; other site 336982007720 active site 336982007721 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 336982007722 putative nucleic acid binding region [nucleotide binding]; other site 336982007723 G-X-X-G motif; other site 336982007724 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 336982007725 RNA binding site [nucleotide binding]; other site 336982007726 domain interface; other site 336982007727 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 336982007728 16S/18S rRNA binding site [nucleotide binding]; other site 336982007729 S13e-L30e interaction site [polypeptide binding]; other site 336982007730 25S rRNA binding site [nucleotide binding]; other site 336982007731 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 336982007732 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 336982007733 active site 336982007734 Riboflavin kinase; Region: Flavokinase; pfam01687 336982007735 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 336982007736 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 336982007737 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 336982007738 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 336982007739 putative DNA binding site [nucleotide binding]; other site 336982007740 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 336982007741 FeoA domain; Region: FeoA; pfam04023 336982007742 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 336982007743 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 336982007744 active site 336982007745 lipid-transfer protein; Provisional; Region: PRK08256 336982007746 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 336982007747 active site 336982007748 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 336982007749 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 336982007750 Probable transposase; Region: OrfB_IS605; pfam01385 336982007751 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 336982007752 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 336982007753 catalytic residues [active] 336982007754 catalytic nucleophile [active] 336982007755 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 336982007756 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 336982007757 RNA binding site [nucleotide binding]; other site 336982007758 active site 336982007759 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 336982007760 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 336982007761 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 336982007762 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 336982007763 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 336982007764 active site 336982007765 metal binding site [ion binding]; metal-binding site 336982007766 Uncharacterized conserved protein [Function unknown]; Region: COG4717 336982007767 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 336982007768 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 336982007769 Predicted acyl esterases [General function prediction only]; Region: COG2936 336982007770 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 336982007771 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 336982007772 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 336982007773 Uncharacterized conserved protein [Function unknown]; Region: COG5586 336982007774 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 336982007775 Integrase core domain; Region: rve; pfam00665 336982007776 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 336982007777 Transposase; Region: DDE_Tnp_ISL3; pfam01610 336982007778 Helix-turn-helix domain; Region: HTH_28; pfam13518 336982007779 Winged helix-turn helix; Region: HTH_29; pfam13551 336982007780 Integrase core domain; Region: rve; pfam00665 336982007781 Integrase core domain; Region: rve_3; pfam13683 336982007782 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 336982007783 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 336982007784 putative transposase OrfB; Reviewed; Region: PHA02517 336982007785 HTH-like domain; Region: HTH_21; pfam13276 336982007786 Integrase core domain; Region: rve; pfam00665 336982007787 Integrase core domain; Region: rve_3; pfam13683 336982007788 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 336982007789 Transposase; Region: HTH_Tnp_1; cl17663 336982007790 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 336982007791 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09636 336982007792 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cd09699 336982007793 CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cd09662 336982007794 CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cd09663 336982007795 CRISPR/Cas system-associated RAMP superfamily protein Csm3; Region: Csm3_III-A; cd09684 336982007796 CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cd09647 336982007797 Predicted CRISPR-associated polymerase [Defense mechanisms]; Region: COG1353 336982007798 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 336982007799 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 336982007800 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4293 336982007801 Uncharacterized conserved protein [Function unknown]; Region: COG2253 336982007802 Protein of unknown function (DUF2005); Region: DUF2005; pfam09407 336982007803 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4293 336982007804 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 336982007805 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 336982007806 putative active site [active] 336982007807 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 336982007808 enoyl-CoA hydratase; Provisional; Region: PRK06190 336982007809 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 336982007810 substrate binding site [chemical binding]; other site 336982007811 oxyanion hole (OAH) forming residues; other site 336982007812 trimer interface [polypeptide binding]; other site 336982007813 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 336982007814 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 336982007815 Walker A/P-loop; other site 336982007816 ATP binding site [chemical binding]; other site 336982007817 Q-loop/lid; other site 336982007818 ABC transporter signature motif; other site 336982007819 Walker B; other site 336982007820 D-loop; other site 336982007821 H-loop/switch region; other site 336982007822 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 336982007823 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 336982007824 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 336982007825 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 336982007826 dimer interface [polypeptide binding]; other site 336982007827 conserved gate region; other site 336982007828 putative PBP binding loops; other site 336982007829 ABC-ATPase subunit interface; other site 336982007830 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 336982007831 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 336982007832 dimer interface [polypeptide binding]; other site 336982007833 conserved gate region; other site 336982007834 putative PBP binding loops; other site 336982007835 ABC-ATPase subunit interface; other site 336982007836 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 336982007837 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 336982007838 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 336982007839 DHH family; Region: DHH; pfam01368 336982007840 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 336982007841 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 336982007842 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 336982007843 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 336982007844 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 336982007845 G1 box; other site 336982007846 putative GEF interaction site [polypeptide binding]; other site 336982007847 GTP/Mg2+ binding site [chemical binding]; other site 336982007848 Switch I region; other site 336982007849 G2 box; other site 336982007850 G3 box; other site 336982007851 Switch II region; other site 336982007852 G4 box; other site 336982007853 G5 box; other site 336982007854 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 336982007855 Translation-initiation factor 2; Region: IF-2; pfam11987 336982007856 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 336982007857 Predicted nucleic-acid-binding protein implicated in transcription termination [Transcription]; Region: COG2740 336982007858 putative RNA binding cleft [nucleotide binding]; other site 336982007859 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 336982007860 NusA N-terminal domain; Region: NusA_N; pfam08529 336982007861 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 336982007862 RNA binding site [nucleotide binding]; other site 336982007863 homodimer interface [polypeptide binding]; other site 336982007864 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 336982007865 G-X-X-G motif; other site 336982007866 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 336982007867 G-X-X-G motif; other site 336982007868 ribosome maturation protein RimP; Reviewed; Region: PRK00092 336982007869 Sm and related proteins; Region: Sm_like; cl00259 336982007870 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 336982007871 putative oligomer interface [polypeptide binding]; other site 336982007872 putative RNA binding site [nucleotide binding]; other site 336982007873 Mitochondrial ATP synthase g subunit; Region: ATP-synt_G; pfam04718 336982007874 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 336982007875 dinuclear metal binding motif [ion binding]; other site 336982007876 prolyl-tRNA synthetase; Provisional; Region: PRK09194 336982007877 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 336982007878 dimer interface [polypeptide binding]; other site 336982007879 motif 1; other site 336982007880 active site 336982007881 motif 2; other site 336982007882 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 336982007883 putative deacylase active site [active] 336982007884 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 336982007885 active site 336982007886 motif 3; other site 336982007887 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 336982007888 anticodon binding site; other site 336982007889 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 336982007890 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 336982007891 putative substrate translocation pore; other site 336982007892 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 336982007893 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 336982007894 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 336982007895 homodimer interface [polypeptide binding]; other site 336982007896 active site 336982007897 SAM binding site [chemical binding]; other site 336982007898 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 336982007899 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 336982007900 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 336982007901 catalytic triad [active] 336982007902 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 336982007903 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 336982007904 homodimer interface [polypeptide binding]; other site 336982007905 Walker A motif; other site 336982007906 ATP binding site [chemical binding]; other site 336982007907 hydroxycobalamin binding site [chemical binding]; other site 336982007908 Walker B motif; other site 336982007909 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 336982007910 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 336982007911 Walker A motif; other site 336982007912 ATP binding site [chemical binding]; other site 336982007913 Walker B motif; other site 336982007914 arginine finger; other site 336982007915 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 336982007916 metal ion-dependent adhesion site (MIDAS); other site 336982007917 Predicted acyltransferase [General function prediction only]; Region: ElaA; COG2153 336982007918 malate:quinone oxidoreductase; Validated; Region: PRK05257 336982007919 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 336982007920 PE family; Region: PE; pfam00934 336982007921 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 336982007922 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 336982007923 mycothione reductase; Reviewed; Region: PRK07846 336982007924 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 336982007925 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 336982007926 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 336982007927 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 336982007928 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 336982007929 short chain dehydrogenase; Provisional; Region: PRK06057 336982007930 classical (c) SDRs; Region: SDR_c; cd05233 336982007931 NAD(P) binding site [chemical binding]; other site 336982007932 active site 336982007933 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 336982007934 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 336982007935 NAD(P) binding site [chemical binding]; other site 336982007936 catalytic residues [active] 336982007937 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 336982007938 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 336982007939 catalytic triad [active] 336982007940 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 336982007941 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 336982007942 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 336982007943 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 336982007944 active site 336982007945 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 336982007946 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 336982007947 putative active site [active] 336982007948 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 336982007949 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 336982007950 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 336982007951 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 336982007952 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 336982007953 Predicted acetyltransferase [General function prediction only]; Region: COG3393 336982007954 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 336982007955 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 336982007956 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 336982007957 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 336982007958 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 336982007959 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 336982007960 active site 336982007961 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 336982007962 protein binding site [polypeptide binding]; other site 336982007963 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 336982007964 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 336982007965 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 336982007966 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 336982007967 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 336982007968 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 336982007969 Fasciclin domain; Region: Fasciclin; pfam02469 336982007970 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 336982007971 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 336982007972 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 336982007973 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 336982007974 catalytic residues [active] 336982007975 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 336982007976 Fasciclin domain; Region: Fasciclin; pfam02469 336982007977 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 336982007978 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 336982007979 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 336982007980 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 336982007981 catalytic residues [active] 336982007982 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 336982007983 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 336982007984 FeS/SAM binding site; other site 336982007985 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 336982007986 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 336982007987 ribosome recycling factor; Reviewed; Region: frr; PRK00083 336982007988 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 336982007989 hinge region; other site 336982007990 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 336982007991 putative nucleotide binding site [chemical binding]; other site 336982007992 uridine monophosphate binding site [chemical binding]; other site 336982007993 homohexameric interface [polypeptide binding]; other site 336982007994 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 336982007995 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 336982007996 DNA binding site [nucleotide binding] 336982007997 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 336982007998 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 336982007999 Probable transposase; Region: OrfB_IS605; pfam01385 336982008000 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 336982008001 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 336982008002 catalytic residues [active] 336982008003 catalytic nucleophile [active] 336982008004 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 336982008005 MarR family; Region: MarR; pfam01047 336982008006 amidase; Provisional; Region: PRK07869 336982008007 Amidase; Region: Amidase; pfam01425 336982008008 elongation factor Ts; Provisional; Region: tsf; PRK09377 336982008009 UBA/TS-N domain; Region: UBA; pfam00627 336982008010 Elongation factor TS; Region: EF_TS; pfam00889 336982008011 Elongation factor TS; Region: EF_TS; pfam00889 336982008012 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 336982008013 rRNA interaction site [nucleotide binding]; other site 336982008014 S8 interaction site; other site 336982008015 putative laminin-1 binding site; other site 336982008016 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 336982008017 Peptidase family M23; Region: Peptidase_M23; pfam01551 336982008018 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982008019 PPE family; Region: PPE; pfam00823 336982008020 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 336982008021 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 336982008022 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 336982008023 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 336982008024 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 336982008025 active site 336982008026 DNA binding site [nucleotide binding] 336982008027 Int/Topo IB signature motif; other site 336982008028 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 336982008029 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 336982008030 FAD binding pocket [chemical binding]; other site 336982008031 FAD binding motif [chemical binding]; other site 336982008032 phosphate binding motif [ion binding]; other site 336982008033 NAD binding pocket [chemical binding]; other site 336982008034 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 336982008035 DNA protecting protein DprA; Region: dprA; TIGR00732 336982008036 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 336982008037 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 336982008038 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 336982008039 Walker A motif; other site 336982008040 ATP binding site [chemical binding]; other site 336982008041 Walker B motif; other site 336982008042 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 336982008043 hypothetical protein; Reviewed; Region: PRK12497 336982008044 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 336982008045 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 336982008046 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 336982008047 putative molybdopterin cofactor binding site [chemical binding]; other site 336982008048 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 336982008049 putative molybdopterin cofactor binding site; other site 336982008050 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 336982008051 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 336982008052 RNA/DNA hybrid binding site [nucleotide binding]; other site 336982008053 active site 336982008054 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 336982008055 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 336982008056 Catalytic site [active] 336982008057 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 336982008058 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 336982008059 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 336982008060 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 336982008061 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 336982008062 RimM N-terminal domain; Region: RimM; pfam01782 336982008063 hypothetical protein; Provisional; Region: PRK02821 336982008064 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 336982008065 G-X-X-G motif; other site 336982008066 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 336982008067 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 336982008068 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 336982008069 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 336982008070 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982008071 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982008072 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 336982008073 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 336982008074 active site 336982008075 putative substrate binding pocket [chemical binding]; other site 336982008076 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 336982008077 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 336982008078 Catalytic domain of Protein Kinases; Region: PKc; cd00180 336982008079 active site 336982008080 ATP binding site [chemical binding]; other site 336982008081 substrate binding site [chemical binding]; other site 336982008082 activation loop (A-loop); other site 336982008083 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 336982008084 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 336982008085 active site 336982008086 signal recognition particle protein; Provisional; Region: PRK10867 336982008087 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 336982008088 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 336982008089 P loop; other site 336982008090 GTP binding site [chemical binding]; other site 336982008091 Signal peptide binding domain; Region: SRP_SPB; pfam02978 336982008092 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 336982008093 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 336982008094 ATP binding site [chemical binding]; other site 336982008095 putative Mg++ binding site [ion binding]; other site 336982008096 PII uridylyl-transferase; Provisional; Region: PRK03381 336982008097 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 336982008098 metal binding triad; other site 336982008099 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 336982008100 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 336982008101 Zn2+ binding site [ion binding]; other site 336982008102 Mg2+ binding site [ion binding]; other site 336982008103 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 336982008104 Nitrogen regulatory protein P-II; Region: P-II; smart00938 336982008105 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 336982008106 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 336982008107 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 336982008108 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 336982008109 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 336982008110 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 336982008111 Walker A/P-loop; other site 336982008112 ATP binding site [chemical binding]; other site 336982008113 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 336982008114 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 336982008115 ABC transporter signature motif; other site 336982008116 Walker B; other site 336982008117 D-loop; other site 336982008118 H-loop/switch region; other site 336982008119 acylphosphatase; Provisional; Region: PRK14422 336982008120 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 336982008121 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 336982008122 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 336982008123 DNA binding site [nucleotide binding] 336982008124 catalytic residue [active] 336982008125 H2TH interface [polypeptide binding]; other site 336982008126 putative catalytic residues [active] 336982008127 turnover-facilitating residue; other site 336982008128 intercalation triad [nucleotide binding]; other site 336982008129 8OG recognition residue [nucleotide binding]; other site 336982008130 putative reading head residues; other site 336982008131 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 336982008132 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 336982008133 ribonuclease III; Reviewed; Region: rnc; PRK00102 336982008134 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 336982008135 dimerization interface [polypeptide binding]; other site 336982008136 active site 336982008137 metal binding site [ion binding]; metal-binding site 336982008138 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 336982008139 dsRNA binding site [nucleotide binding]; other site 336982008140 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 336982008141 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 336982008142 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 336982008143 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 336982008144 acyl-CoA synthetase; Validated; Region: PRK05850 336982008145 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 336982008146 acyl-activating enzyme (AAE) consensus motif; other site 336982008147 active site 336982008148 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 336982008149 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 336982008150 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 336982008151 active site 336982008152 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 336982008153 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 336982008154 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 336982008155 NADP binding site [chemical binding]; other site 336982008156 KR domain; Region: KR; pfam08659 336982008157 active site 336982008158 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 336982008159 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 336982008160 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 336982008161 active site 336982008162 Acyl transferase domain; Region: Acyl_transf_1; cl08282 336982008163 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 336982008164 KR domain; Region: KR; pfam08659 336982008165 NADP binding site [chemical binding]; other site 336982008166 active site 336982008167 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 336982008168 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 336982008169 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 336982008170 active site 336982008171 Acyl transferase domain; Region: Acyl_transf_1; cl08282 336982008172 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 336982008173 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982008174 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 336982008175 Enoylreductase; Region: PKS_ER; smart00829 336982008176 NAD(P) binding site [chemical binding]; other site 336982008177 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 336982008178 KR domain; Region: KR; pfam08659 336982008179 putative NADP binding site [chemical binding]; other site 336982008180 active site 336982008181 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 336982008182 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 336982008183 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 336982008184 active site 336982008185 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 336982008186 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 336982008187 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 336982008188 KR domain; Region: KR; pfam08659 336982008189 putative NADP binding site [chemical binding]; other site 336982008190 active site 336982008191 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 336982008192 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 336982008193 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 336982008194 active site 336982008195 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 336982008196 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 336982008197 Condensation domain; Region: Condensation; pfam00668 336982008198 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 336982008199 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 336982008200 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 336982008201 Walker A/P-loop; other site 336982008202 ATP binding site [chemical binding]; other site 336982008203 Q-loop/lid; other site 336982008204 ABC transporter signature motif; other site 336982008205 Walker B; other site 336982008206 D-loop; other site 336982008207 H-loop/switch region; other site 336982008208 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 336982008209 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 336982008210 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 336982008211 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 336982008212 acyltransferase PapA5; Provisional; Region: PRK09294 336982008213 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 336982008214 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 336982008215 active site 336982008216 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 336982008217 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 336982008218 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982008219 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 336982008220 Enoylreductase; Region: PKS_ER; smart00829 336982008221 NAD(P) binding site [chemical binding]; other site 336982008222 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 336982008223 KR domain; Region: KR; pfam08659 336982008224 putative NADP binding site [chemical binding]; other site 336982008225 active site 336982008226 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 336982008227 acyl-CoA synthetase; Validated; Region: PRK05850 336982008228 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 336982008229 acyl-activating enzyme (AAE) consensus motif; other site 336982008230 active site 336982008231 MMPL family; Region: MMPL; pfam03176 336982008232 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 336982008233 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 336982008234 Integrase core domain; Region: rve; pfam00665 336982008235 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 336982008236 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 336982008237 ATP binding site [chemical binding]; other site 336982008238 Walker A motif; other site 336982008239 Walker B motif; other site 336982008240 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 336982008241 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 336982008242 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 336982008243 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 336982008244 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982008245 Enoylreductase; Region: PKS_ER; smart00829 336982008246 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 336982008247 NAD(P) binding site [chemical binding]; other site 336982008248 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 336982008249 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 336982008250 putative NADP binding site [chemical binding]; other site 336982008251 active site 336982008252 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 336982008253 Erythronolide synthase docking; Region: Docking; pfam08990 336982008254 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 336982008255 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 336982008256 active site 336982008257 acyl-CoA synthetase; Validated; Region: PRK06060 336982008258 Benzoate CoA ligase (BCL) and similar adenylate forming enzymes; Region: BCL_like; cd05919 336982008259 dimer interface [polypeptide binding]; other site 336982008260 acyl-activating enzyme (AAE) consensus motif; other site 336982008261 putative active site [active] 336982008262 putative AMP binding site [chemical binding]; other site 336982008263 putative CoA binding site [chemical binding]; other site 336982008264 chemical substrate binding site [chemical binding]; other site 336982008265 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 336982008266 4-hydroxybenzoate synthetase (chorismate lyase) [Coenzyme metabolism]; Region: UbiC; COG3161 336982008267 acyl-CoA synthetase; Validated; Region: PRK05850 336982008268 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 336982008269 acyl-activating enzyme (AAE) consensus motif; other site 336982008270 active site 336982008271 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 336982008272 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 336982008273 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 336982008274 S-adenosylmethionine binding site [chemical binding]; other site 336982008275 Uncharacterized conserved protein [Function unknown]; Region: COG3268 336982008276 Methyltransferase domain; Region: Methyltransf_23; pfam13489 336982008277 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 336982008278 S-adenosylmethionine binding site [chemical binding]; other site 336982008279 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 336982008280 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 336982008281 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 336982008282 metal-binding site 336982008283 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 336982008284 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 336982008285 active site 336982008286 TDP-binding site; other site 336982008287 acceptor substrate-binding pocket; other site 336982008288 Cephalosporin hydroxylase [Defense mechanisms]; Region: CmcI; COG3510 336982008289 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 336982008290 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 336982008291 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 336982008292 active site 336982008293 TDP-binding site; other site 336982008294 acceptor substrate-binding pocket; other site 336982008295 Predicted permease; Region: DUF318; pfam03773 336982008296 formyltetrahydrofolate deformylase; Region: PurU; TIGR00655 336982008297 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 336982008298 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 336982008299 putative active site [active] 336982008300 putative substrate binding site [chemical binding]; other site 336982008301 putative cosubstrate binding site; other site 336982008302 catalytic site [active] 336982008303 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 336982008304 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 336982008305 active site 336982008306 (T/H)XGH motif; other site 336982008307 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 336982008308 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 336982008309 S-adenosylmethionine binding site [chemical binding]; other site 336982008310 pyruvate carboxylase; Reviewed; Region: PRK12999 336982008311 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 336982008312 ATP-grasp domain; Region: ATP-grasp_4; cl17255 336982008313 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 336982008314 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 336982008315 active site 336982008316 catalytic residues [active] 336982008317 metal binding site [ion binding]; metal-binding site 336982008318 homodimer binding site [polypeptide binding]; other site 336982008319 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 336982008320 carboxyltransferase (CT) interaction site; other site 336982008321 biotinylation site [posttranslational modification]; other site 336982008322 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 336982008323 putative active site [active] 336982008324 redox center [active] 336982008325 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 336982008326 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 336982008327 catalytic residues [active] 336982008328 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 336982008329 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 336982008330 substrate binding pocket [chemical binding]; other site 336982008331 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 336982008332 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 336982008333 active site 336982008334 catalytic tetrad [active] 336982008335 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 336982008336 RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200 336982008337 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 336982008338 generic binding surface II; other site 336982008339 ssDNA binding site; other site 336982008340 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 336982008341 ATP binding site [chemical binding]; other site 336982008342 putative Mg++ binding site [ion binding]; other site 336982008343 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 336982008344 nucleotide binding region [chemical binding]; other site 336982008345 ATP-binding site [chemical binding]; other site 336982008346 DAK2 domain; Region: Dak2; cl03685 336982008347 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 336982008348 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 336982008349 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 336982008350 ligand binding site [chemical binding]; other site 336982008351 active site 336982008352 UGI interface [polypeptide binding]; other site 336982008353 catalytic site [active] 336982008354 thiamine monophosphate kinase; Provisional; Region: PRK05731 336982008355 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 336982008356 ATP binding site [chemical binding]; other site 336982008357 dimerization interface [polypeptide binding]; other site 336982008358 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 336982008359 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 336982008360 Probable transposase; Region: OrfB_IS605; pfam01385 336982008361 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 336982008362 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 336982008363 catalytic residues [active] 336982008364 catalytic nucleophile [active] 336982008365 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 336982008366 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 336982008367 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 336982008368 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 336982008369 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 336982008370 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 336982008371 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 336982008372 Predicted nucleotidyltransferase, CobY/MobA/RfbA family [General function prediction only]; Region: COG1920 336982008373 polyphosphate kinase; Provisional; Region: PRK05443 336982008374 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 336982008375 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 336982008376 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 336982008377 putative domain interface [polypeptide binding]; other site 336982008378 putative active site [active] 336982008379 catalytic site [active] 336982008380 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 336982008381 putative domain interface [polypeptide binding]; other site 336982008382 putative active site [active] 336982008383 catalytic site [active] 336982008384 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 336982008385 active site 336982008386 Ap6A binding site [chemical binding]; other site 336982008387 nudix motif; other site 336982008388 metal binding site [ion binding]; metal-binding site 336982008389 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 336982008390 catalytic core [active] 336982008391 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 336982008392 IHF - DNA interface [nucleotide binding]; other site 336982008393 IHF dimer interface [polypeptide binding]; other site 336982008394 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 336982008395 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 336982008396 substrate binding site [chemical binding]; other site 336982008397 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 336982008398 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 336982008399 substrate binding site [chemical binding]; other site 336982008400 ligand binding site [chemical binding]; other site 336982008401 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 336982008402 Transcriptional regulator [Transcription]; Region: IclR; COG1414 336982008403 Bacterial transcriptional regulator; Region: IclR; pfam01614 336982008404 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 336982008405 S-adenosylmethionine binding site [chemical binding]; other site 336982008406 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 336982008407 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 336982008408 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 336982008409 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 336982008410 active site 336982008411 HIGH motif; other site 336982008412 nucleotide binding site [chemical binding]; other site 336982008413 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 336982008414 active site 336982008415 KMSKS motif; other site 336982008416 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 336982008417 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 336982008418 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 336982008419 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 336982008420 Major Facilitator Superfamily; Region: MFS_1; pfam07690 336982008421 putative substrate translocation pore; other site 336982008422 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 336982008423 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 336982008424 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 336982008425 ligand binding site [chemical binding]; other site 336982008426 NAD binding site [chemical binding]; other site 336982008427 dimerization interface [polypeptide binding]; other site 336982008428 catalytic site [active] 336982008429 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 336982008430 putative L-serine binding site [chemical binding]; other site 336982008431 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 336982008432 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 336982008433 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 336982008434 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 336982008435 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 336982008436 ketol-acid reductoisomerase; Provisional; Region: PRK05479 336982008437 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 336982008438 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 336982008439 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 336982008440 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 336982008441 putative valine binding site [chemical binding]; other site 336982008442 dimer interface [polypeptide binding]; other site 336982008443 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 336982008444 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 336982008445 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 336982008446 PYR/PP interface [polypeptide binding]; other site 336982008447 dimer interface [polypeptide binding]; other site 336982008448 TPP binding site [chemical binding]; other site 336982008449 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 336982008450 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 336982008451 TPP-binding site [chemical binding]; other site 336982008452 dimer interface [polypeptide binding]; other site 336982008453 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 336982008454 Predicted membrane protein [Function unknown]; Region: COG2259 336982008455 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 336982008456 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 336982008457 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 336982008458 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 336982008459 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 336982008460 GatB domain; Region: GatB_Yqey; smart00845 336982008461 6-phosphofructokinase; Provisional; Region: PRK03202 336982008462 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 336982008463 active site 336982008464 ADP/pyrophosphate binding site [chemical binding]; other site 336982008465 dimerization interface [polypeptide binding]; other site 336982008466 allosteric effector site; other site 336982008467 fructose-1,6-bisphosphate binding site; other site 336982008468 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 336982008469 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 336982008470 aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, C subunit; Region: gatC; TIGR00135 336982008471 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 336982008472 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 336982008473 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 336982008474 nucleotide binding pocket [chemical binding]; other site 336982008475 K-X-D-G motif; other site 336982008476 catalytic site [active] 336982008477 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 336982008478 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 336982008479 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 336982008480 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 336982008481 Dimer interface [polypeptide binding]; other site 336982008482 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 336982008483 PknH-like extracellular domain; Region: PknH_C; pfam14032 336982008484 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 336982008485 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982008486 PPE family; Region: PPE; pfam00823 336982008487 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 336982008488 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982008489 PPE family; Region: PPE; pfam00823 336982008490 Transposase, Mutator family; Region: Transposase_mut; pfam00872 336982008491 MULE transposase domain; Region: MULE; pfam10551 336982008492 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 336982008493 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 336982008494 Ligand Binding Site [chemical binding]; other site 336982008495 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 336982008496 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 336982008497 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 336982008498 catalytic residue [active] 336982008499 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 336982008500 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 336982008501 putative acyl-acceptor binding pocket; other site 336982008502 Putative hemolysin [General function prediction only]; Region: COG3176 336982008503 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 336982008504 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 336982008505 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 336982008506 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 336982008507 Ligand binding site [chemical binding]; other site 336982008508 Electron transfer flavoprotein domain; Region: ETF; pfam01012 336982008509 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 336982008510 S-adenosylmethionine binding site [chemical binding]; other site 336982008511 Uncharacterized conserved protein [Function unknown]; Region: COG1543 336982008512 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 336982008513 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 336982008514 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 336982008515 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 336982008516 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 336982008517 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 336982008518 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 336982008519 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 336982008520 trimer interface [polypeptide binding]; other site 336982008521 active site 336982008522 substrate binding site [chemical binding]; other site 336982008523 CoA binding site [chemical binding]; other site 336982008524 FOG: WD40-like repeat [Function unknown]; Region: COG1520 336982008525 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 336982008526 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982008527 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 336982008528 S-adenosylmethionine binding site [chemical binding]; other site 336982008529 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 336982008530 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 336982008531 substrate binding site [chemical binding]; other site 336982008532 oxyanion hole (OAH) forming residues; other site 336982008533 trimer interface [polypeptide binding]; other site 336982008534 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 336982008535 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 336982008536 Walker A/P-loop; other site 336982008537 ATP binding site [chemical binding]; other site 336982008538 Q-loop/lid; other site 336982008539 ABC transporter signature motif; other site 336982008540 Walker B; other site 336982008541 D-loop; other site 336982008542 H-loop/switch region; other site 336982008543 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 336982008544 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 336982008545 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 336982008546 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 336982008547 motif II; other site 336982008548 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 336982008549 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 336982008550 D-pathway; other site 336982008551 Putative ubiquinol binding site [chemical binding]; other site 336982008552 Low-spin heme (heme b) binding site [chemical binding]; other site 336982008553 Putative water exit pathway; other site 336982008554 Binuclear center (heme o3/CuB) [ion binding]; other site 336982008555 K-pathway; other site 336982008556 Putative proton exit pathway; other site 336982008557 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 336982008558 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 336982008559 siderophore binding site; other site 336982008560 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 336982008561 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 336982008562 putative NAD(P) binding site [chemical binding]; other site 336982008563 putative substrate binding site [chemical binding]; other site 336982008564 catalytic Zn binding site [ion binding]; other site 336982008565 structural Zn binding site [ion binding]; other site 336982008566 dimer interface [polypeptide binding]; other site 336982008567 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 336982008568 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 336982008569 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 336982008570 dimer interface [polypeptide binding]; other site 336982008571 putative radical transfer pathway; other site 336982008572 diiron center [ion binding]; other site 336982008573 tyrosyl radical; other site 336982008574 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 336982008575 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 336982008576 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982008577 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982008578 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 336982008579 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 336982008580 Class I ribonucleotide reductase; Region: RNR_I; cd01679 336982008581 active site 336982008582 dimer interface [polypeptide binding]; other site 336982008583 catalytic residues [active] 336982008584 effector binding site; other site 336982008585 R2 peptide binding site; other site 336982008586 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 336982008587 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 336982008588 catalytic residues [active] 336982008589 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 336982008590 Predicted flavoprotein [General function prediction only]; Region: COG0431 336982008591 DNA polymerase IV; Validated; Region: PRK03352 336982008592 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 336982008593 active site 336982008594 DNA binding site [nucleotide binding] 336982008595 short chain dehydrogenase; Provisional; Region: PRK07832 336982008596 classical (c) SDRs; Region: SDR_c; cd05233 336982008597 NAD(P) binding site [chemical binding]; other site 336982008598 active site 336982008599 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982008600 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982008601 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 336982008602 Cytochrome P450; Region: p450; cl12078 336982008603 Transcriptional regulators [Transcription]; Region: FadR; COG2186 336982008604 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 336982008605 DNA-binding site [nucleotide binding]; DNA binding site 336982008606 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 336982008607 Transcriptional regulators [Transcription]; Region: FadR; COG2186 336982008608 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 336982008609 DNA-binding site [nucleotide binding]; DNA binding site 336982008610 FCD domain; Region: FCD; pfam07729 336982008611 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 336982008612 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 336982008613 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 336982008614 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 336982008615 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 336982008616 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 336982008617 active site 336982008618 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 336982008619 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 336982008620 active site 336982008621 DNA binding site [nucleotide binding] 336982008622 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 336982008623 DNA binding site [nucleotide binding] 336982008624 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 336982008625 Carbon starvation protein CstA; Region: CstA; pfam02554 336982008626 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 336982008627 Predicted membrane protein [Function unknown]; Region: COG2259 336982008628 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 336982008629 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 336982008630 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982008631 Protein of unknown function (DUF732); Region: DUF732; pfam05305 336982008632 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 336982008633 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 336982008634 active site 336982008635 substrate binding site [chemical binding]; other site 336982008636 metal binding site [ion binding]; metal-binding site 336982008637 camphor resistance protein CrcB; Provisional; Region: PRK14216 336982008638 camphor resistance protein CrcB; Provisional; Region: PRK14228 336982008639 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 336982008640 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 336982008641 Uncharacterized ACR, COG1993; Region: DUF190; pfam02641 336982008642 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 336982008643 Uncharacterized conserved protein [Function unknown]; Region: COG3189 336982008644 Domain of unknown function (DUF222); Region: DUF222; pfam02720 336982008645 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 336982008646 active site 336982008647 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 336982008648 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 336982008649 putative hydrophobic ligand binding site [chemical binding]; other site 336982008650 protein interface [polypeptide binding]; other site 336982008651 gate; other site 336982008652 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 336982008653 Sulfatase; Region: Sulfatase; pfam00884 336982008654 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 336982008655 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 336982008656 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 336982008657 Catalytic domain of Protein Kinases; Region: PKc; cd00180 336982008658 active site 336982008659 ATP binding site [chemical binding]; other site 336982008660 substrate binding site [chemical binding]; other site 336982008661 activation loop (A-loop); other site 336982008662 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 336982008663 AAA ATPase domain; Region: AAA_16; pfam13191 336982008664 Nucleotidyl transferase of unknown function (DUF2204); Region: DUF2204; pfam09970 336982008665 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 336982008666 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 336982008667 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 336982008668 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 336982008669 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 336982008670 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 336982008671 short chain dehydrogenase; Provisional; Region: PRK07832 336982008672 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982008673 NAD(P) binding site [chemical binding]; other site 336982008674 active site 336982008675 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 336982008676 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 336982008677 NAD binding site [chemical binding]; other site 336982008678 catalytic Zn binding site [ion binding]; other site 336982008679 substrate binding site [chemical binding]; other site 336982008680 structural Zn binding site [ion binding]; other site 336982008681 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 336982008682 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 336982008683 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 336982008684 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 336982008685 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 336982008686 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 336982008687 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 336982008688 acyl-activating enzyme (AAE) consensus motif; other site 336982008689 AMP binding site [chemical binding]; other site 336982008690 active site 336982008691 CoA binding site [chemical binding]; other site 336982008692 SPFH domain / Band 7 family; Region: Band_7; pfam01145 336982008693 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 336982008694 Patatin-like phospholipase; Region: Patatin; pfam01734 336982008695 Protein of unknown function (DUF808); Region: DUF808; cl01002 336982008696 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 336982008697 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 336982008698 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 336982008699 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 336982008700 active site 336982008701 Predicted transcriptional regulators [Transcription]; Region: COG1733 336982008702 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 336982008703 dimerization interface [polypeptide binding]; other site 336982008704 putative DNA binding site [nucleotide binding]; other site 336982008705 putative Zn2+ binding site [ion binding]; other site 336982008706 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 336982008707 PE family; Region: PE; pfam00934 336982008708 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 336982008709 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 336982008710 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 336982008711 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 336982008712 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 336982008713 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 336982008714 SmpB-tmRNA interface; other site 336982008715 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 336982008716 FtsX-like permease family; Region: FtsX; pfam02687 336982008717 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 336982008718 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 336982008719 Walker A/P-loop; other site 336982008720 ATP binding site [chemical binding]; other site 336982008721 Q-loop/lid; other site 336982008722 ABC transporter signature motif; other site 336982008723 Walker B; other site 336982008724 D-loop; other site 336982008725 H-loop/switch region; other site 336982008726 Mechanosensitive ion channel; Region: MS_channel; pfam00924 336982008727 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 336982008728 peptide chain release factor 2; Validated; Region: prfB; PRK00578 336982008729 This domain is found in peptide chain release factors; Region: PCRF; smart00937 336982008730 RF-1 domain; Region: RF-1; pfam00472 336982008731 ferredoxin-NADP+ reductase; Region: PLN02852 336982008732 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 336982008733 FAD binding domain; Region: FAD_binding_4; pfam01565 336982008734 Molybdenum cofactor biosynthesis enzyme [Coenzyme metabolism]; Region: MoaA; COG2896 336982008735 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 336982008736 FeS/SAM binding site; other site 336982008737 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 336982008738 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 336982008739 aromatic arch; other site 336982008740 DCoH dimer interaction site [polypeptide binding]; other site 336982008741 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 336982008742 DCoH tetramer interaction site [polypeptide binding]; other site 336982008743 substrate binding site [chemical binding]; other site 336982008744 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 336982008745 trimer interface [polypeptide binding]; other site 336982008746 dimer interface [polypeptide binding]; other site 336982008747 putative active site [active] 336982008748 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 336982008749 MoaE interaction surface [polypeptide binding]; other site 336982008750 MoeB interaction surface [polypeptide binding]; other site 336982008751 thiocarboxylated glycine; other site 336982008752 hydrolase, haloacid dehalogenase-like family; Mapped to H37Rv Rv3113; interrupted by transposases 336982008753 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 336982008754 Transposase; Region: HTH_Tnp_1; cl17663 336982008755 putative transposase OrfB; Reviewed; Region: PHA02517 336982008756 HTH-like domain; Region: HTH_21; pfam13276 336982008757 Integrase core domain; Region: rve; pfam00665 336982008758 Integrase core domain; Region: rve_3; pfam13683 336982008759 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 336982008760 nucleoside/Zn binding site; other site 336982008761 dimer interface [polypeptide binding]; other site 336982008762 catalytic motif [active] 336982008763 Transposase, Mutator family; Region: Transposase_mut; pfam00872 336982008764 MULE transposase domain; Region: MULE; pfam10551 336982008765 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 336982008766 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 336982008767 ATP binding site [chemical binding]; other site 336982008768 substrate interface [chemical binding]; other site 336982008769 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 336982008770 active site residue [active] 336982008771 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 336982008772 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 336982008773 active site residue [active] 336982008774 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 336982008775 active site residue [active] 336982008776 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 336982008777 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 336982008778 MoaE homodimer interface [polypeptide binding]; other site 336982008779 MoaD interaction [polypeptide binding]; other site 336982008780 active site residues [active] 336982008781 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 336982008782 S-adenosylmethionine binding site [chemical binding]; other site 336982008783 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 336982008784 Cytochrome P450; Region: p450; cl12078 336982008785 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 336982008786 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 336982008787 DNA binding site [nucleotide binding] 336982008788 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982008789 PPE family; Region: PPE; pfam00823 336982008790 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 336982008791 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 336982008792 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 336982008793 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 336982008794 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 336982008795 dimer interface [polypeptide binding]; other site 336982008796 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 336982008797 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 336982008798 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 336982008799 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 336982008800 Histidine kinase; Region: HisKA_3; pfam07730 336982008801 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 336982008802 ATP binding site [chemical binding]; other site 336982008803 Mg2+ binding site [ion binding]; other site 336982008804 G-X-G motif; other site 336982008805 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 336982008806 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 336982008807 active site 336982008808 phosphorylation site [posttranslational modification] 336982008809 intermolecular recognition site; other site 336982008810 dimerization interface [polypeptide binding]; other site 336982008811 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 336982008812 DNA binding residues [nucleotide binding] 336982008813 dimerization interface [polypeptide binding]; other site 336982008814 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 336982008815 Ligand Binding Site [chemical binding]; other site 336982008816 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982008817 PPE family; Region: PPE; pfam00823 336982008818 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982008819 PPE family; Region: PPE; pfam00823 336982008820 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 336982008821 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 336982008822 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 336982008823 active site 336982008824 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 336982008825 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 336982008826 FeS/SAM binding site; other site 336982008827 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 336982008828 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 336982008829 active site 336982008830 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 336982008831 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 336982008832 active site 336982008833 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 336982008834 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 336982008835 NAD(P) binding site [chemical binding]; other site 336982008836 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 336982008837 active site 336982008838 phosphorylation site [posttranslational modification] 336982008839 intermolecular recognition site; other site 336982008840 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982008841 PPE family; Region: PPE; pfam00823 336982008842 NADH dehydrogenase subunit A; Validated; Region: PRK07928 336982008843 NADH dehydrogenase subunit B; Validated; Region: PRK06411 336982008844 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 336982008845 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 336982008846 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 336982008847 NADH dehydrogenase subunit D; Validated; Region: PRK06075 336982008848 NADH dehydrogenase subunit E; Validated; Region: PRK07539 336982008849 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 336982008850 putative dimer interface [polypeptide binding]; other site 336982008851 [2Fe-2S] cluster binding site [ion binding]; other site 336982008852 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 336982008853 SLBB domain; Region: SLBB; pfam10531 336982008854 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 336982008855 NADH dehydrogenase subunit G; Validated; Region: PRK07860 336982008856 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 336982008857 catalytic loop [active] 336982008858 iron binding site [ion binding]; other site 336982008859 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 336982008860 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 336982008861 [4Fe-4S] binding site [ion binding]; other site 336982008862 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 336982008863 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 336982008864 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 336982008865 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 336982008866 4Fe-4S binding domain; Region: Fer4; pfam00037 336982008867 4Fe-4S binding domain; Region: Fer4; pfam00037 336982008868 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 336982008869 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 336982008870 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 336982008871 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 336982008872 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 336982008873 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 336982008874 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 336982008875 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 336982008876 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 336982008877 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982008878 PPE family; Region: PPE; pfam00823 336982008879 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 336982008880 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982008881 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 336982008882 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 336982008883 [2Fe-2S] cluster binding site [ion binding]; other site 336982008884 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_1; cd08885 336982008885 putative alpha subunit interface [polypeptide binding]; other site 336982008886 putative active site [active] 336982008887 putative substrate binding site [chemical binding]; other site 336982008888 Fe binding site [ion binding]; other site 336982008889 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 336982008890 Protein of unknown function DUF58; Region: DUF58; pfam01882 336982008891 MoxR-like ATPases [General function prediction only]; Region: COG0714 336982008892 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 336982008893 Walker A motif; other site 336982008894 ATP binding site [chemical binding]; other site 336982008895 Walker B motif; other site 336982008896 arginine finger; other site 336982008897 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 336982008898 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982008899 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982008900 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 336982008901 putative active site [active] 336982008902 putative substrate binding site [chemical binding]; other site 336982008903 ATP binding site [chemical binding]; other site 336982008904 Phosphotransferase enzyme family; Region: APH; pfam01636 336982008905 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 336982008906 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 336982008907 hydroxyglutarate oxidase; Provisional; Region: PRK11728 336982008908 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 336982008909 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 336982008910 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982008911 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982008912 short chain dehydrogenase; Validated; Region: PRK08264 336982008913 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982008914 NAD(P) binding site [chemical binding]; other site 336982008915 active site 336982008916 amidase; Provisional; Region: PRK06170 336982008917 Amidase; Region: Amidase; pfam01425 336982008918 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 336982008919 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 336982008920 TAP-like protein; Region: Abhydrolase_4; pfam08386 336982008921 Domain of unknown function (DUF385); Region: DUF385; pfam04075 336982008922 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 336982008923 AAA domain; Region: AAA_14; pfam13173 336982008924 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 336982008925 putative active site [active] 336982008926 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 336982008927 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4683 336982008928 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 336982008929 non-specific DNA binding site [nucleotide binding]; other site 336982008930 salt bridge; other site 336982008931 sequence-specific DNA binding site [nucleotide binding]; other site 336982008932 putative transposase OrfB; Reviewed; Region: PHA02517 336982008933 HTH-like domain; Region: HTH_21; pfam13276 336982008934 Integrase core domain; Region: rve; pfam00665 336982008935 Integrase core domain; Region: rve_3; pfam13683 336982008936 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 336982008937 Transposase; Region: HTH_Tnp_1; cl17663 336982008938 RES domain; Region: RES; pfam08808 336982008939 Winged helix-turn helix; Region: HTH_29; pfam13551 336982008940 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 336982008941 Helix-turn-helix domain; Region: HTH_38; pfam13936 336982008942 Integrase core domain; Region: rve; pfam00665 336982008943 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 336982008944 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 336982008945 hypothetical protein; Validated; Region: PRK00068 336982008946 Uncharacterized conserved protein [Function unknown]; Region: COG1615 336982008947 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 336982008948 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 336982008949 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 336982008950 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 336982008951 Uncharacterized conserved protein [Function unknown]; Region: COG5282 336982008952 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 336982008953 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 336982008954 ABC1 family; Region: ABC1; pfam03109 336982008955 Phosphotransferase enzyme family; Region: APH; pfam01636 336982008956 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 336982008957 active site 336982008958 ATP binding site [chemical binding]; other site 336982008959 Transcription factor WhiB; Region: Whib; pfam02467 336982008960 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 336982008961 Part of AAA domain; Region: AAA_19; pfam13245 336982008962 Family description; Region: UvrD_C_2; pfam13538 336982008963 HRDC domain; Region: HRDC; pfam00570 336982008964 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 336982008965 catalytic residues [active] 336982008966 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 336982008967 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 336982008968 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 336982008969 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 336982008970 putative NADH binding site [chemical binding]; other site 336982008971 putative active site [active] 336982008972 nudix motif; other site 336982008973 putative metal binding site [ion binding]; other site 336982008974 Ion channel; Region: Ion_trans_2; pfam07885 336982008975 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 336982008976 TrkA-N domain; Region: TrkA_N; pfam02254 336982008977 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 336982008978 Part of AAA domain; Region: AAA_19; pfam13245 336982008979 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 336982008980 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 336982008981 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 336982008982 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 336982008983 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 336982008984 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 336982008985 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 336982008986 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 336982008987 active site 336982008988 DNA binding site [nucleotide binding] 336982008989 TIGR02569 family protein; Region: TIGR02569_actnb 336982008990 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 336982008991 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 336982008992 ATP binding site [chemical binding]; other site 336982008993 substrate interface [chemical binding]; other site 336982008994 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 336982008995 active site residue [active] 336982008996 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 336982008997 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982008998 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982008999 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 336982009000 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like; Region: MiaE_2; pfam13794 336982009001 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 336982009002 DEAD-like helicases superfamily; Region: DEXDc; smart00487 336982009003 ATP binding site [chemical binding]; other site 336982009004 Mg++ binding site [ion binding]; other site 336982009005 motif III; other site 336982009006 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 336982009007 nucleotide binding region [chemical binding]; other site 336982009008 ATP-binding site [chemical binding]; other site 336982009009 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 336982009010 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 336982009011 P-loop; other site 336982009012 Magnesium ion binding site [ion binding]; other site 336982009013 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 336982009014 Magnesium ion binding site [ion binding]; other site 336982009015 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 336982009016 catalytic core [active] 336982009017 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 336982009018 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 336982009019 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 336982009020 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 336982009021 Transcription factor WhiB; Region: Whib; pfam02467 336982009022 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 336982009023 PAS domain S-box; Region: sensory_box; TIGR00229 336982009024 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 336982009025 Histidine kinase; Region: HisKA_2; pfam07568 336982009026 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 336982009027 ATP binding site [chemical binding]; other site 336982009028 Mg2+ binding site [ion binding]; other site 336982009029 G-X-G motif; other site 336982009030 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 336982009031 carboxyltransferase (CT) interaction site; other site 336982009032 biotinylation site [posttranslational modification]; other site 336982009033 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 336982009034 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 336982009035 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 336982009036 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 336982009037 DNA binding residues [nucleotide binding] 336982009038 short chain dehydrogenase; Provisional; Region: PRK08278 336982009039 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 336982009040 NAD(P) binding site [chemical binding]; other site 336982009041 homodimer interface [polypeptide binding]; other site 336982009042 active site 336982009043 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 336982009044 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 336982009045 putative deacylase active site [active] 336982009046 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 336982009047 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 336982009048 Coenzyme A binding pocket [chemical binding]; other site 336982009049 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 336982009050 Phosphotransferase enzyme family; Region: APH; pfam01636 336982009051 putative active site [active] 336982009052 putative substrate binding site [chemical binding]; other site 336982009053 ATP binding site [chemical binding]; other site 336982009054 Uncharacterized conserved protein [Function unknown]; Region: COG2135 336982009055 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 336982009056 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 336982009057 hinge; other site 336982009058 active site 336982009059 Predicted GTPases [General function prediction only]; Region: COG1162 336982009060 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 336982009061 GTPase/Zn-binding domain interface [polypeptide binding]; other site 336982009062 GTP/Mg2+ binding site [chemical binding]; other site 336982009063 G4 box; other site 336982009064 G5 box; other site 336982009065 G1 box; other site 336982009066 Switch I region; other site 336982009067 G2 box; other site 336982009068 G3 box; other site 336982009069 Switch II region; other site 336982009070 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 336982009071 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 336982009072 putative di-iron ligands [ion binding]; other site 336982009073 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 336982009074 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 336982009075 FAD binding pocket [chemical binding]; other site 336982009076 FAD binding motif [chemical binding]; other site 336982009077 phosphate binding motif [ion binding]; other site 336982009078 beta-alpha-beta structure motif; other site 336982009079 NAD binding pocket [chemical binding]; other site 336982009080 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 336982009081 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 336982009082 catalytic loop [active] 336982009083 iron binding site [ion binding]; other site 336982009084 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 336982009085 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 336982009086 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 336982009087 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 336982009088 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 336982009089 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 336982009090 TrkA-C domain; Region: TrkA_C; pfam02080 336982009091 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 336982009092 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 336982009093 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 336982009094 putative substrate translocation pore; other site 336982009095 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 336982009096 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 336982009097 ligand binding site [chemical binding]; other site 336982009098 flexible hinge region; other site 336982009099 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 336982009100 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 336982009101 nucleophile elbow; other site 336982009102 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 336982009103 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 336982009104 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 336982009105 30S subunit binding site; other site 336982009106 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 336982009107 active site 336982009108 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 336982009109 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 336982009110 lipoprotein LpqB; Provisional; Region: PRK13616 336982009111 Sporulation and spore germination; Region: Germane; pfam10646 336982009112 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 336982009113 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 336982009114 dimerization interface [polypeptide binding]; other site 336982009115 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 336982009116 dimer interface [polypeptide binding]; other site 336982009117 phosphorylation site [posttranslational modification] 336982009118 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 336982009119 ATP binding site [chemical binding]; other site 336982009120 Mg2+ binding site [ion binding]; other site 336982009121 G-X-G motif; other site 336982009122 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 336982009123 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 336982009124 active site 336982009125 phosphorylation site [posttranslational modification] 336982009126 intermolecular recognition site; other site 336982009127 dimerization interface [polypeptide binding]; other site 336982009128 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 336982009129 DNA binding site [nucleotide binding] 336982009130 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 336982009131 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 336982009132 TMP-binding site; other site 336982009133 ATP-binding site [chemical binding]; other site 336982009134 Adenosylhomocysteinase; Provisional; Region: PTZ00075 336982009135 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 336982009136 homotetramer interface [polypeptide binding]; other site 336982009137 ligand binding site [chemical binding]; other site 336982009138 catalytic site [active] 336982009139 NAD binding site [chemical binding]; other site 336982009140 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982009141 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 336982009142 Rubredoxin [Energy production and conversion]; Region: COG1773 336982009143 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 336982009144 iron binding site [ion binding]; other site 336982009145 Rubredoxin [Energy production and conversion]; Region: COG1773 336982009146 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 336982009147 iron binding site [ion binding]; other site 336982009148 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 336982009149 Fatty acid desaturase; Region: FA_desaturase; pfam00487 336982009150 Di-iron ligands [ion binding]; other site 336982009151 amino acid transporter; Region: 2A0306; TIGR00909 336982009152 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 336982009153 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 336982009154 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 336982009155 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 336982009156 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 336982009157 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 336982009158 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 336982009159 active site 336982009160 substrate binding site [chemical binding]; other site 336982009161 metal binding site [ion binding]; metal-binding site 336982009162 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 336982009163 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 336982009164 Transcription factor WhiB; Region: Whib; pfam02467 336982009165 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 336982009166 LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186 336982009167 phosphate binding site [ion binding]; other site 336982009168 dimer interface [polypeptide binding]; other site 336982009169 substrate binding site [chemical binding]; other site 336982009170 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 336982009171 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 336982009172 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 336982009173 putative FMN binding site [chemical binding]; other site 336982009174 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 336982009175 Methyltransferase domain; Region: Methyltransf_26; pfam13659 336982009176 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 336982009177 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 336982009178 active site 336982009179 Substrate binding site; other site 336982009180 Mg++ binding site; other site 336982009181 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 336982009182 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 336982009183 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 336982009184 Probable Catalytic site; other site 336982009185 metal-binding site 336982009186 dTDP-4-dehydrorhamnose reductase; Region: rmlD; TIGR01214 336982009187 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 336982009188 NADP binding site [chemical binding]; other site 336982009189 active site 336982009190 putative substrate binding site [chemical binding]; other site 336982009191 Transcriptional regulator [Transcription]; Region: LytR; COG1316 336982009192 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 336982009193 TIGR03089 family protein; Region: TIGR03089 336982009194 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 336982009195 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 336982009196 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 336982009197 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 336982009198 active site 336982009199 motif I; other site 336982009200 motif II; other site 336982009201 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 336982009202 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 336982009203 CoA-transferase family III; Region: CoA_transf_3; pfam02515 336982009204 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 336982009205 Sulfate transporter family; Region: Sulfate_transp; pfam00916 336982009206 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: CynT; COG0288 336982009207 active site clefts [active] 336982009208 zinc binding site [ion binding]; other site 336982009209 dimer interface [polypeptide binding]; other site 336982009210 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 336982009211 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 336982009212 FAD binding site [chemical binding]; other site 336982009213 homotetramer interface [polypeptide binding]; other site 336982009214 substrate binding pocket [chemical binding]; other site 336982009215 catalytic base [active] 336982009216 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 336982009217 Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) [Nucleotide transport and metabolism]; Region: PurK; COG0026 336982009218 ATP-grasp domain; Region: ATP-grasp; pfam02222 336982009219 Predicted membrane protein [Function unknown]; Region: COG2246 336982009220 GtrA-like protein; Region: GtrA; pfam04138 336982009221 Bacterial PH domain; Region: DUF304; pfam03703 336982009222 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 336982009223 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 336982009224 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 336982009225 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 336982009226 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 336982009227 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 336982009228 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 336982009229 Maf-like protein; Region: Maf; pfam02545 336982009230 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 336982009231 active site 336982009232 dimer interface [polypeptide binding]; other site 336982009233 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 336982009234 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 336982009235 active site residue [active] 336982009236 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 336982009237 active site residue [active] 336982009238 Fe-S metabolism associated domain; Region: SufE; pfam02657 336982009239 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 336982009240 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 336982009241 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 336982009242 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 336982009243 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 336982009244 carboxyltransferase (CT) interaction site; other site 336982009245 biotinylation site [posttranslational modification]; other site 336982009246 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 336982009247 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 336982009248 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 336982009249 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 336982009250 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 336982009251 L-lysine aminotransferase; Provisional; Region: PRK08297 336982009252 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 336982009253 inhibitor-cofactor binding pocket; inhibition site 336982009254 pyridoxal 5'-phosphate binding site [chemical binding]; other site 336982009255 catalytic residue [active] 336982009256 putative DNA binding site [nucleotide binding]; other site 336982009257 dimerization interface [polypeptide binding]; other site 336982009258 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 336982009259 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 336982009260 putative Zn2+ binding site [ion binding]; other site 336982009261 AsnC family; Region: AsnC_trans_reg; pfam01037 336982009262 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 336982009263 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 336982009264 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 336982009265 tetrameric interface [polypeptide binding]; other site 336982009266 NAD binding site [chemical binding]; other site 336982009267 catalytic residues [active] 336982009268 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 336982009269 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982009270 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982009271 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 336982009272 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 336982009273 ATP binding site [chemical binding]; other site 336982009274 putative Mg++ binding site [ion binding]; other site 336982009275 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 336982009276 nucleotide binding region [chemical binding]; other site 336982009277 ATP-binding site [chemical binding]; other site 336982009278 DEAD/H associated; Region: DEAD_assoc; pfam08494 336982009279 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 336982009280 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 336982009281 putative DNA binding site [nucleotide binding]; other site 336982009282 catalytic residue [active] 336982009283 putative H2TH interface [polypeptide binding]; other site 336982009284 putative catalytic residues [active] 336982009285 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 336982009286 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 336982009287 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 336982009288 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 336982009289 Sulfatase; Region: Sulfatase; pfam00884 336982009290 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 336982009291 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 336982009292 probable active site [active] 336982009293 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 336982009294 PhoU domain; Region: PhoU; pfam01895 336982009295 PhoU domain; Region: PhoU; pfam01895 336982009296 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 336982009297 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 336982009298 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 336982009299 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 336982009300 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 336982009301 putative active site pocket [active] 336982009302 dimerization interface [polypeptide binding]; other site 336982009303 putative catalytic residue [active] 336982009304 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 336982009305 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 336982009306 metal binding site [ion binding]; metal-binding site 336982009307 putative dimer interface [polypeptide binding]; other site 336982009308 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 336982009309 amidohydrolase; Region: amidohydrolases; TIGR01891 336982009310 metal binding site [ion binding]; metal-binding site 336982009311 purine nucleoside phosphorylase; Provisional; Region: PRK08202 336982009312 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 336982009313 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 336982009314 active site 336982009315 substrate binding site [chemical binding]; other site 336982009316 metal binding site [ion binding]; metal-binding site 336982009317 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 336982009318 active site 336982009319 Phosphoesterase family; Region: Phosphoesterase; pfam04185 336982009320 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 336982009321 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 336982009322 adenosine deaminase; Provisional; Region: PRK09358 336982009323 active site 336982009324 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 336982009325 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 336982009326 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 336982009327 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 336982009328 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 336982009329 active site 336982009330 catalytic motif [active] 336982009331 Zn binding site [ion binding]; other site 336982009332 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 336982009333 putative Iron-sulfur protein interface [polypeptide binding]; other site 336982009334 putative proximal heme binding site [chemical binding]; other site 336982009335 putative SdhD-like interface [polypeptide binding]; other site 336982009336 putative distal heme binding site [chemical binding]; other site 336982009337 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 336982009338 putative Iron-sulfur protein interface [polypeptide binding]; other site 336982009339 putative proximal heme binding site [chemical binding]; other site 336982009340 putative SdhC-like subunit interface [polypeptide binding]; other site 336982009341 putative distal heme binding site [chemical binding]; other site 336982009342 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 336982009343 L-aspartate oxidase; Provisional; Region: PRK06175 336982009344 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 336982009345 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 336982009346 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 336982009347 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 336982009348 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 336982009349 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 336982009350 S-adenosylmethionine binding site [chemical binding]; other site 336982009351 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 336982009352 MoaE interaction surface [polypeptide binding]; other site 336982009353 MoeB interaction surface [polypeptide binding]; other site 336982009354 thiocarboxylated glycine; other site 336982009355 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 336982009356 MoaE homodimer interface [polypeptide binding]; other site 336982009357 MoaD interaction [polypeptide binding]; other site 336982009358 active site residues [active] 336982009359 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 336982009360 trimer interface [polypeptide binding]; other site 336982009361 dimer interface [polypeptide binding]; other site 336982009362 putative active site [active] 336982009363 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 336982009364 aromatic arch; other site 336982009365 DCoH dimer interaction site [polypeptide binding]; other site 336982009366 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 336982009367 DCoH tetramer interaction site [polypeptide binding]; other site 336982009368 substrate binding site [chemical binding]; other site 336982009369 putative transposase OrfB; Reviewed; Region: PHA02517 336982009370 HTH-like domain; Region: HTH_21; pfam13276 336982009371 Integrase core domain; Region: rve; pfam00665 336982009372 Integrase core domain; Region: rve_3; pfam13683 336982009373 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 336982009374 Transposase; Region: HTH_Tnp_1; cl17663 336982009375 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 336982009376 Transposase; Region: DEDD_Tnp_IS110; pfam01548 336982009377 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 336982009378 Uncharacterized conserved protein [Function unknown]; Region: COG2128 336982009379 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 336982009380 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 336982009381 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 336982009382 DNA binding residues [nucleotide binding] 336982009383 SnoaL-like domain; Region: SnoaL_2; pfam12680 336982009384 hypothetical protein; Provisional; Region: PRK06541 336982009385 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 336982009386 inhibitor-cofactor binding pocket; inhibition site 336982009387 pyridoxal 5'-phosphate binding site [chemical binding]; other site 336982009388 catalytic residue [active] 336982009389 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 336982009390 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 336982009391 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 336982009392 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 336982009393 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 336982009394 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 336982009395 active site 336982009396 dimer interface [polypeptide binding]; other site 336982009397 Protein of unknown function (DUF732); Region: DUF732; pfam05305 336982009398 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 336982009399 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 336982009400 DNA binding residues [nucleotide binding] 336982009401 dimer interface [polypeptide binding]; other site 336982009402 metal binding site [ion binding]; metal-binding site 336982009403 inner membrane protein YhjD; Region: TIGR00766 336982009404 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 336982009405 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 336982009406 active site 336982009407 HIGH motif; other site 336982009408 dimer interface [polypeptide binding]; other site 336982009409 KMSKS motif; other site 336982009410 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 336982009411 isocitrate dehydrogenase; Validated; Region: PRK08299 336982009412 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 336982009413 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 336982009414 homodimer interface [polypeptide binding]; other site 336982009415 substrate-cofactor binding pocket; other site 336982009416 pyridoxal 5'-phosphate binding site [chemical binding]; other site 336982009417 catalytic residue [active] 336982009418 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 336982009419 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 336982009420 Methyltransferase domain; Region: Methyltransf_23; pfam13489 336982009421 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 336982009422 S-adenosylmethionine binding site [chemical binding]; other site 336982009423 PPE family; Region: PPE; pfam00823 336982009424 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982009425 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982009426 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982009427 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982009428 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982009429 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982009430 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982009431 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982009432 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982009433 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982009434 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982009435 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982009436 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982009437 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982009438 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982009439 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982009440 PE family; Region: PE; pfam00934 336982009441 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 336982009442 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982009443 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982009444 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982009445 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982009446 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982009447 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982009448 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982009449 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982009450 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982009451 PPE family; Region: PPE; pfam00823 336982009452 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982009453 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982009454 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982009455 Transposase; Region: DEDD_Tnp_IS110; pfam01548 336982009456 Transposase; Region: DDE_Tnp_ISL3; pfam01610 336982009457 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982009458 PPE family; Region: PPE; pfam00823 336982009459 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982009460 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982009461 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982009462 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982009463 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982009464 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982009465 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982009466 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982009467 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982009468 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982009469 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982009470 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982009471 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982009472 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982009473 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982009474 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982009475 Berberine and berberine like; Region: BBE; pfam08031 336982009476 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 336982009477 Protein of unknown function (DUF732); Region: DUF732; pfam05305 336982009478 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 336982009479 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 336982009480 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 336982009481 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 336982009482 homodimer interface [polypeptide binding]; other site 336982009483 NADP binding site [chemical binding]; other site 336982009484 substrate binding site [chemical binding]; other site 336982009485 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 336982009486 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 336982009487 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 336982009488 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 336982009489 active site 336982009490 FMN binding site [chemical binding]; other site 336982009491 substrate binding site [chemical binding]; other site 336982009492 putative catalytic residue [active] 336982009493 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 336982009494 phosphate binding site [ion binding]; other site 336982009495 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 336982009496 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 336982009497 phosphopeptide binding site; other site 336982009498 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 336982009499 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 336982009500 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 336982009501 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 336982009502 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 336982009503 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 336982009504 G1 box; other site 336982009505 GTP/Mg2+ binding site [chemical binding]; other site 336982009506 G2 box; other site 336982009507 Switch I region; other site 336982009508 G3 box; other site 336982009509 Switch II region; other site 336982009510 G4 box; other site 336982009511 G5 box; other site 336982009512 Protein of unknown function (DUF742); Region: DUF742; pfam05331 336982009513 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 336982009514 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 336982009515 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 336982009516 ATP binding site [chemical binding]; other site 336982009517 Mg2+ binding site [ion binding]; other site 336982009518 G-X-G motif; other site 336982009519 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 336982009520 PE family; Region: PE; pfam00934 336982009521 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 336982009522 FMN binding site [chemical binding]; other site 336982009523 dimer interface [polypeptide binding]; other site 336982009524 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 336982009525 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 336982009526 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 336982009527 active site 336982009528 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 336982009529 generic binding surface II; other site 336982009530 generic binding surface I; other site 336982009531 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 336982009532 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 336982009533 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 336982009534 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 336982009535 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 336982009536 active site 336982009537 motif I; other site 336982009538 motif II; other site 336982009539 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 336982009540 substrate binding site [chemical binding]; other site 336982009541 oxyanion hole (OAH) forming residues; other site 336982009542 trimer interface [polypeptide binding]; other site 336982009543 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 336982009544 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 336982009545 Amidase; Region: Amidase; pfam01425 336982009546 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 336982009547 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 336982009548 motif II; other site 336982009549 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 336982009550 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 336982009551 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 336982009552 TPP-binding site [chemical binding]; other site 336982009553 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 336982009554 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 336982009555 PYR/PP interface [polypeptide binding]; other site 336982009556 dimer interface [polypeptide binding]; other site 336982009557 TPP binding site [chemical binding]; other site 336982009558 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 336982009559 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 336982009560 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 336982009561 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 336982009562 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 336982009563 substrate binding pocket [chemical binding]; other site 336982009564 chain length determination region; other site 336982009565 substrate-Mg2+ binding site; other site 336982009566 catalytic residues [active] 336982009567 aspartate-rich region 1; other site 336982009568 active site lid residues [active] 336982009569 aspartate-rich region 2; other site 336982009570 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 336982009571 putative active site [active] 336982009572 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 336982009573 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 336982009574 Transposase domain (DUF772); Region: DUF772; pfam05598 336982009575 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 336982009576 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 336982009577 PE family; Region: PE; pfam00934 336982009578 enoyl-CoA hydratase; Region: PLN02864 336982009579 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 336982009580 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 336982009581 dimer interaction site [polypeptide binding]; other site 336982009582 substrate-binding tunnel; other site 336982009583 active site 336982009584 catalytic site [active] 336982009585 substrate binding site [chemical binding]; other site 336982009586 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 336982009587 short chain dehydrogenase; Provisional; Region: PRK07201 336982009588 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 336982009589 putative NAD(P) binding site [chemical binding]; other site 336982009590 active site 336982009591 putative substrate binding site [chemical binding]; other site 336982009592 classical (c) SDRs; Region: SDR_c; cd05233 336982009593 NAD(P) binding site [chemical binding]; other site 336982009594 active site 336982009595 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 336982009596 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 336982009597 S-adenosylmethionine binding site [chemical binding]; other site 336982009598 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 336982009599 active site 336982009600 DNA Polymerase Y-family; Region: PolY_like; cd03468 336982009601 DNA binding site [nucleotide binding] 336982009602 GMP synthase; Reviewed; Region: guaA; PRK00074 336982009603 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 336982009604 AMP/PPi binding site [chemical binding]; other site 336982009605 candidate oxyanion hole; other site 336982009606 catalytic triad [active] 336982009607 potential glutamine specificity residues [chemical binding]; other site 336982009608 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 336982009609 ATP Binding subdomain [chemical binding]; other site 336982009610 Ligand Binding sites [chemical binding]; other site 336982009611 Dimerization subdomain; other site 336982009612 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 336982009613 active site lid residues [active] 336982009614 substrate binding pocket [chemical binding]; other site 336982009615 catalytic residues [active] 336982009616 substrate-Mg2+ binding site; other site 336982009617 aspartate-rich region 1; other site 336982009618 aspartate-rich region 2; other site 336982009619 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 336982009620 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 336982009621 substrate binding pocket [chemical binding]; other site 336982009622 chain length determination region; other site 336982009623 substrate-Mg2+ binding site; other site 336982009624 catalytic residues [active] 336982009625 aspartate-rich region 1; other site 336982009626 active site lid residues [active] 336982009627 aspartate-rich region 2; other site 336982009628 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 336982009629 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 336982009630 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 336982009631 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 336982009632 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 336982009633 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 336982009634 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 336982009635 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 336982009636 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 336982009637 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 336982009638 inhibitor-cofactor binding pocket; inhibition site 336982009639 pyridoxal 5'-phosphate binding site [chemical binding]; other site 336982009640 catalytic residue [active] 336982009641 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 336982009642 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 336982009643 hypothetical protein; Provisional; Region: PRK07579 336982009644 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 336982009645 active site 336982009646 cosubstrate binding site; other site 336982009647 substrate binding site [chemical binding]; other site 336982009648 catalytic site [active] 336982009649 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982009650 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982009651 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 336982009652 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 336982009653 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 336982009654 putative active site [active] 336982009655 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 336982009656 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 336982009657 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 336982009658 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 336982009659 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 336982009660 phosphate binding site [ion binding]; other site 336982009661 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 336982009662 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 336982009663 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 336982009664 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 336982009665 active site 336982009666 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 336982009667 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 336982009668 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 336982009669 DNA binding residues [nucleotide binding] 336982009670 Transcription factor WhiB; Region: Whib; pfam02467 336982009671 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 336982009672 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 336982009673 ring oligomerisation interface [polypeptide binding]; other site 336982009674 ATP/Mg binding site [chemical binding]; other site 336982009675 stacking interactions; other site 336982009676 hinge regions; other site 336982009677 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 336982009678 oligomerisation interface [polypeptide binding]; other site 336982009679 mobile loop; other site 336982009680 roof hairpin; other site 336982009681 UGMP family protein; Validated; Region: PRK09604 336982009682 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 336982009683 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 336982009684 Coenzyme A binding pocket [chemical binding]; other site 336982009685 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 336982009686 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 336982009687 alanine racemase; Reviewed; Region: alr; PRK00053 336982009688 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 336982009689 active site 336982009690 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 336982009691 dimer interface [polypeptide binding]; other site 336982009692 substrate binding site [chemical binding]; other site 336982009693 catalytic residues [active] 336982009694 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982009695 PPE family; Region: PPE; pfam00823 336982009696 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982009697 PPE family; Region: PPE; pfam00823 336982009698 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 336982009699 Integrase core domain; Region: rve; pfam00665 336982009700 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 336982009701 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 336982009702 Walker A motif; other site 336982009703 ATP binding site [chemical binding]; other site 336982009704 Walker B motif; other site 336982009705 arginine finger; other site 336982009706 PE family; Region: PE; pfam00934 336982009707 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982009708 PPE family; Region: PPE; pfam00823 336982009709 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 336982009710 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982009711 PPE family; Region: PPE; pfam00823 336982009712 Integrase core domain; Region: rve; pfam00665 336982009713 Integrase core domain; Region: rve_3; pfam13683 336982009714 Transposase, Mutator family; Region: Transposase_mut; pfam00872 336982009715 MULE transposase domain; Region: MULE; pfam10551 336982009716 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 336982009717 pyridoxal 5'-phosphate binding site [chemical binding]; other site 336982009718 catalytic residue [active] 336982009719 Uncharacterized conserved protein [Function unknown]; Region: COG0062 336982009720 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 336982009721 putative substrate binding site [chemical binding]; other site 336982009722 putative ATP binding site [chemical binding]; other site 336982009723 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 336982009724 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 336982009725 glutaminase active site [active] 336982009726 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 336982009727 dimer interface [polypeptide binding]; other site 336982009728 active site 336982009729 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 336982009730 dimer interface [polypeptide binding]; other site 336982009731 active site 336982009732 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 336982009733 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 336982009734 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 336982009735 active site 336982009736 substrate binding site [chemical binding]; other site 336982009737 metal binding site [ion binding]; metal-binding site 336982009738 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 336982009739 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 336982009740 23S rRNA interface [nucleotide binding]; other site 336982009741 L3 interface [polypeptide binding]; other site 336982009742 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 336982009743 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 336982009744 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 336982009745 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 336982009746 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 336982009747 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 336982009748 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 336982009749 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 336982009750 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 336982009751 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 336982009752 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 336982009753 active site 336982009754 catalytic residues [active] 336982009755 Protein of unknown function (DUF690); Region: DUF690; cl04939 336982009756 Cutinase; Region: Cutinase; pfam01083 336982009757 Cutinase; Region: Cutinase; pfam01083 336982009758 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 336982009759 Pseudouridylate synthase [Translation, ribosomal structure and biogenesis]; Region: TruA; COG0101 336982009760 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 336982009761 dimerization interface 3.5A [polypeptide binding]; other site 336982009762 active site 336982009763 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 336982009764 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 336982009765 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 336982009766 alphaNTD - beta interaction site [polypeptide binding]; other site 336982009767 alphaNTD homodimer interface [polypeptide binding]; other site 336982009768 alphaNTD - beta' interaction site [polypeptide binding]; other site 336982009769 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 336982009770 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 336982009771 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 336982009772 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 336982009773 RNA binding surface [nucleotide binding]; other site 336982009774 30S ribosomal protein S11; Validated; Region: PRK05309 336982009775 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 336982009776 30S ribosomal protein S13; Region: bact_S13; TIGR03631 336982009777 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 336982009778 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 336982009779 rRNA binding site [nucleotide binding]; other site 336982009780 predicted 30S ribosome binding site; other site 336982009781 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 336982009782 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 336982009783 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 336982009784 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 336982009785 NAD binding site [chemical binding]; other site 336982009786 substrate binding site [chemical binding]; other site 336982009787 homodimer interface [polypeptide binding]; other site 336982009788 active site 336982009789 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 336982009790 Domain of unknown function (DUF222); Region: DUF222; pfam02720 336982009791 Domain of unknown function (DUF222); Region: DUF222; pfam02720 336982009792 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 336982009793 active site 336982009794 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 336982009795 extended (e) SDRs; Region: SDR_e; cd08946 336982009796 NAD(P) binding site [chemical binding]; other site 336982009797 active site 336982009798 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 336982009799 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 336982009800 active site 336982009801 catalytic residues [active] 336982009802 metal binding site [ion binding]; metal-binding site 336982009803 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 336982009804 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 336982009805 PYR/PP interface [polypeptide binding]; other site 336982009806 dimer interface [polypeptide binding]; other site 336982009807 TPP binding site [chemical binding]; other site 336982009808 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 336982009809 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 336982009810 TPP-binding site [chemical binding]; other site 336982009811 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 336982009812 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 336982009813 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 336982009814 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 336982009815 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 336982009816 metabolite-proton symporter; Region: 2A0106; TIGR00883 336982009817 putative substrate translocation pore; other site 336982009818 PE family; Region: PE; pfam00934 336982009819 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982009820 PPE family; Region: PPE; pfam00823 336982009821 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 336982009822 patatin-related protein; Region: TIGR03607 336982009823 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 336982009824 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 336982009825 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 336982009826 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 336982009827 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 336982009828 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 336982009829 Transcriptional regulator [Transcription]; Region: LytR; COG1316 336982009830 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 336982009831 short chain dehydrogenase; Provisional; Region: PRK05875 336982009832 classical (c) SDRs; Region: SDR_c; cd05233 336982009833 NAD(P) binding site [chemical binding]; other site 336982009834 active site 336982009835 Predicted membrane protein [Function unknown]; Region: COG2259 336982009836 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 336982009837 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 336982009838 Predicted transcriptional regulators [Transcription]; Region: COG1695 336982009839 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 336982009840 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 336982009841 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 336982009842 active site 336982009843 homotetramer interface [polypeptide binding]; other site 336982009844 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 336982009845 mce related protein; Region: MCE; pfam02470 336982009846 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 336982009847 mce related protein; Region: MCE; pfam02470 336982009848 mce related protein; Region: MCE; pfam02470 336982009849 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 336982009850 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 336982009851 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 336982009852 mce related protein; Region: MCE; pfam02470 336982009853 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 336982009854 mce related protein; Region: MCE; pfam02470 336982009855 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 336982009856 mce related protein; Region: MCE; pfam02470 336982009857 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 336982009858 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 336982009859 Permease; Region: Permease; pfam02405 336982009860 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 336982009861 Permease; Region: Permease; pfam02405 336982009862 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 336982009863 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982009864 NAD(P) binding site [chemical binding]; other site 336982009865 active site 336982009866 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 336982009867 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 336982009868 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 336982009869 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 336982009870 FAD binding site [chemical binding]; other site 336982009871 substrate binding site [chemical binding]; other site 336982009872 catalytic base [active] 336982009873 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 336982009874 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 336982009875 active site 336982009876 acyl-CoA synthetase; Validated; Region: PRK07867 336982009877 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 336982009878 acyl-activating enzyme (AAE) consensus motif; other site 336982009879 putative AMP binding site [chemical binding]; other site 336982009880 putative active site [active] 336982009881 putative CoA binding site [chemical binding]; other site 336982009882 PE family; Region: PE; pfam00934 336982009883 PE family; Region: PE; pfam00934 336982009884 hypothetical protein; Validated; Region: PRK07586 336982009885 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 336982009886 PYR/PP interface [polypeptide binding]; other site 336982009887 dimer interface [polypeptide binding]; other site 336982009888 TPP binding site [chemical binding]; other site 336982009889 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 336982009890 TPP-binding site [chemical binding]; other site 336982009891 dimer interface [polypeptide binding]; other site 336982009892 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 336982009893 PE family; Region: PE; pfam00934 336982009894 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 336982009895 CoA binding site [chemical binding]; other site 336982009896 PE family; Region: PE; pfam00934 336982009897 acyl-CoA synthetase; Validated; Region: PRK07798 336982009898 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 336982009899 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 336982009900 acyl-activating enzyme (AAE) consensus motif; other site 336982009901 acyl-activating enzyme (AAE) consensus motif; other site 336982009902 putative AMP binding site [chemical binding]; other site 336982009903 putative active site [active] 336982009904 putative CoA binding site [chemical binding]; other site 336982009905 enoyl-CoA hydratase; Provisional; Region: PRK07799 336982009906 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 336982009907 substrate binding site [chemical binding]; other site 336982009908 oxyanion hole (OAH) forming residues; other site 336982009909 trimer interface [polypeptide binding]; other site 336982009910 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 336982009911 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 336982009912 Cytochrome P450; Region: p450; cl12078 336982009913 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 336982009914 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 336982009915 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 336982009916 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 336982009917 DUF35 OB-fold domain; Region: DUF35; pfam01796 336982009918 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 336982009919 DUF35 OB-fold domain; Region: DUF35; pfam01796 336982009920 lipid-transfer protein; Provisional; Region: PRK07937 336982009921 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 336982009922 active site 336982009923 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 336982009924 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 336982009925 active site 336982009926 NHL repeat; Region: NHL; pfam01436 336982009927 Uncharacterized conserved protein [Function unknown]; Region: COG3391 336982009928 NHL repeat; Region: NHL; pfam01436 336982009929 NHL repeat; Region: NHL; pfam01436 336982009930 NHL repeat; Region: NHL; pfam01436 336982009931 NHL repeat; Region: NHL; pfam01436 336982009932 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 336982009933 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 336982009934 trimer interface [polypeptide binding]; other site 336982009935 putative metal binding site [ion binding]; other site 336982009936 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 336982009937 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 336982009938 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 336982009939 short chain dehydrogenase; Provisional; Region: PRK07890 336982009940 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982009941 NAD(P) binding site [chemical binding]; other site 336982009942 active site 336982009943 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982009944 PPE family; Region: PPE; pfam00823 336982009945 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 336982009946 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982009947 PPE family; Region: PPE; pfam00823 336982009948 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982009949 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982009950 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 336982009951 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 336982009952 active site 336982009953 catalytic residues [active] 336982009954 metal binding site [ion binding]; metal-binding site 336982009955 DmpG-like communication domain; Region: DmpG_comm; pfam07836 336982009956 acetaldehyde dehydrogenase; Validated; Region: PRK08300 336982009957 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 336982009958 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 336982009959 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971 336982009960 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 336982009961 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 336982009962 enoyl-CoA hydratase; Region: PLN02864 336982009963 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 336982009964 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 336982009965 dimer interaction site [polypeptide binding]; other site 336982009966 substrate-binding tunnel; other site 336982009967 active site 336982009968 catalytic site [active] 336982009969 substrate binding site [chemical binding]; other site 336982009970 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982009971 PPE family; Region: PPE; pfam00823 336982009972 PE-PPE domain; Region: PE-PPE; pfam08237 336982009973 lipid-transfer protein; Provisional; Region: PRK07855 336982009974 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 336982009975 active site 336982009976 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 336982009977 putative active site [active] 336982009978 putative catalytic site [active] 336982009979 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 336982009980 active site 336982009981 catalytic site [active] 336982009982 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 336982009983 DUF35 OB-fold domain; Region: DUF35; pfam01796 336982009984 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 336982009985 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 336982009986 active site 336982009987 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 336982009988 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 336982009989 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 336982009990 active site 336982009991 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 336982009992 Cytochrome P450; Region: p450; cl12078 336982009993 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 336982009994 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 336982009995 dimer interface [polypeptide binding]; other site 336982009996 active site 336982009997 Domain of unknown function (DUF385); Region: DUF385; pfam04075 336982009998 short chain dehydrogenase; Provisional; Region: PRK07791 336982009999 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 336982010000 homodimer interface [polypeptide binding]; other site 336982010001 NAD binding site [chemical binding]; other site 336982010002 active site 336982010003 short chain dehydrogenase; Provisional; Region: PRK07856 336982010004 classical (c) SDRs; Region: SDR_c; cd05233 336982010005 NAD(P) binding site [chemical binding]; other site 336982010006 active site 336982010007 enoyl-CoA hydratase; Provisional; Region: PRK06495 336982010008 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 336982010009 substrate binding site [chemical binding]; other site 336982010010 oxyanion hole (OAH) forming residues; other site 336982010011 trimer interface [polypeptide binding]; other site 336982010012 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 336982010013 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057 336982010014 Nitronate monooxygenase; Region: NMO; pfam03060 336982010015 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 336982010016 FMN binding site [chemical binding]; other site 336982010017 substrate binding site [chemical binding]; other site 336982010018 putative catalytic residue [active] 336982010019 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 336982010020 Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514 336982010021 putative di-iron ligands [ion binding]; other site 336982010022 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 336982010023 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 336982010024 FAD binding pocket [chemical binding]; other site 336982010025 FAD binding motif [chemical binding]; other site 336982010026 phosphate binding motif [ion binding]; other site 336982010027 beta-alpha-beta structure motif; other site 336982010028 NAD(p) ribose binding residues [chemical binding]; other site 336982010029 NAD binding pocket [chemical binding]; other site 336982010030 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 336982010031 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 336982010032 catalytic loop [active] 336982010033 iron binding site [ion binding]; other site 336982010034 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 336982010035 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 336982010036 putative active site [active] 336982010037 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 336982010038 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 336982010039 dimer interface [polypeptide binding]; other site 336982010040 active site 336982010041 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982010042 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982010043 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982010044 PPE family; Region: PPE; pfam00823 336982010045 short chain dehydrogenase; Provisional; Region: PRK07831 336982010046 classical (c) SDRs; Region: SDR_c; cd05233 336982010047 NAD(P) binding site [chemical binding]; other site 336982010048 active site 336982010049 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 336982010050 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 336982010051 active site 336982010052 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 336982010053 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 336982010054 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 336982010055 acyl-activating enzyme (AAE) consensus motif; other site 336982010056 putative AMP binding site [chemical binding]; other site 336982010057 putative active site [active] 336982010058 putative CoA binding site [chemical binding]; other site 336982010059 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 336982010060 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 336982010061 active site 336982010062 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 336982010063 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 336982010064 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 336982010065 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 336982010066 active site 336982010067 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 336982010068 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 336982010069 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 336982010070 active site 336982010071 aspartate aminotransferase; Provisional; Region: PRK05764 336982010072 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 336982010073 pyridoxal 5'-phosphate binding site [chemical binding]; other site 336982010074 homodimer interface [polypeptide binding]; other site 336982010075 catalytic residue [active] 336982010076 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 336982010077 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 336982010078 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 336982010079 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 336982010080 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 336982010081 active site 336982010082 Fe binding site [ion binding]; other site 336982010083 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 336982010084 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 336982010085 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 336982010086 Flavin binding site [chemical binding]; other site 336982010087 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 336982010088 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 336982010089 FAD binding pocket [chemical binding]; other site 336982010090 FAD binding motif [chemical binding]; other site 336982010091 phosphate binding motif [ion binding]; other site 336982010092 beta-alpha-beta structure motif; other site 336982010093 NAD(p) ribose binding residues [chemical binding]; other site 336982010094 NAD binding pocket [chemical binding]; other site 336982010095 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 336982010096 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 336982010097 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 336982010098 catalytic loop [active] 336982010099 iron binding site [ion binding]; other site 336982010100 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 336982010101 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 336982010102 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 336982010103 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 336982010104 active site 336982010105 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982010106 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982010107 Transcriptional regulators [Transcription]; Region: PurR; COG1609 336982010108 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 336982010109 DNA binding site [nucleotide binding] 336982010110 domain linker motif; other site 336982010111 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 336982010112 putative dimerization interface [polypeptide binding]; other site 336982010113 putative ligand binding site [chemical binding]; other site 336982010114 PknH-like extracellular domain; Region: PknH_C; pfam14032 336982010115 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 336982010116 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 336982010117 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 336982010118 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 336982010119 transmembrane helices; other site 336982010120 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 336982010121 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 336982010122 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 336982010123 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 336982010124 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 336982010125 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 336982010126 active site 336982010127 HIGH motif; other site 336982010128 nucleotide binding site [chemical binding]; other site 336982010129 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 336982010130 KMSKS motif; other site 336982010131 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 336982010132 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 336982010133 homotrimer interaction site [polypeptide binding]; other site 336982010134 zinc binding site [ion binding]; other site 336982010135 CDP-binding sites; other site 336982010136 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 336982010137 substrate binding site; other site 336982010138 dimer interface; other site 336982010139 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 336982010140 DNA repair protein RadA; Provisional; Region: PRK11823 336982010141 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 336982010142 Walker A motif/ATP binding site; other site 336982010143 ATP binding site [chemical binding]; other site 336982010144 Walker B motif; other site 336982010145 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 336982010146 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 336982010147 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 336982010148 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 336982010149 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 336982010150 active site clefts [active] 336982010151 zinc binding site [ion binding]; other site 336982010152 dimer interface [polypeptide binding]; other site 336982010153 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 336982010154 endonuclease III; Region: ENDO3c; smart00478 336982010155 minor groove reading motif; other site 336982010156 helix-hairpin-helix signature motif; other site 336982010157 substrate binding pocket [chemical binding]; other site 336982010158 active site 336982010159 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 336982010160 PE family; Region: PE; pfam00934 336982010161 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 336982010162 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 336982010163 catalytic site [active] 336982010164 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 336982010165 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 336982010166 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 336982010167 Ami_2 domain; Region: Ami_2; smart00644 336982010168 amidase catalytic site [active] 336982010169 Zn binding residues [ion binding]; other site 336982010170 substrate binding site [chemical binding]; other site 336982010171 PE family; Region: PE; pfam00934 336982010172 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 336982010173 Clp amino terminal domain; Region: Clp_N; pfam02861 336982010174 Clp amino terminal domain; Region: Clp_N; pfam02861 336982010175 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 336982010176 Walker A motif; other site 336982010177 ATP binding site [chemical binding]; other site 336982010178 Walker B motif; other site 336982010179 arginine finger; other site 336982010180 UvrB/uvrC motif; Region: UVR; pfam02151 336982010181 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 336982010182 Walker A motif; other site 336982010183 ATP binding site [chemical binding]; other site 336982010184 Walker B motif; other site 336982010185 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 336982010186 Lsr2; Region: Lsr2; pfam11774 336982010187 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 336982010188 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 336982010189 dimer interface [polypeptide binding]; other site 336982010190 putative anticodon binding site; other site 336982010191 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 336982010192 motif 1; other site 336982010193 dimer interface [polypeptide binding]; other site 336982010194 active site 336982010195 motif 2; other site 336982010196 motif 3; other site 336982010197 pantothenate kinase; Reviewed; Region: PRK13318 336982010198 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 336982010199 tetramerization interface [polypeptide binding]; other site 336982010200 active site 336982010201 Pantoate-beta-alanine ligase; Region: PanC; cd00560 336982010202 pantoate--beta-alanine ligase; Region: panC; TIGR00018 336982010203 active site 336982010204 ATP-binding site [chemical binding]; other site 336982010205 pantoate-binding site; other site 336982010206 HXXH motif; other site 336982010207 Rossmann-like domain; Region: Rossmann-like; pfam10727 336982010208 Uncharacterized conserved protein [Function unknown]; Region: COG5495 336982010209 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 336982010210 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 336982010211 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 336982010212 catalytic center binding site [active] 336982010213 ATP binding site [chemical binding]; other site 336982010214 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 336982010215 homooctamer interface [polypeptide binding]; other site 336982010216 active site 336982010217 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 336982010218 dihydropteroate synthase; Region: DHPS; TIGR01496 336982010219 substrate binding pocket [chemical binding]; other site 336982010220 dimer interface [polypeptide binding]; other site 336982010221 inhibitor binding site; inhibition site 336982010222 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 336982010223 homodecamer interface [polypeptide binding]; other site 336982010224 GTP cyclohydrolase I; Provisional; Region: PLN03044 336982010225 active site 336982010226 putative catalytic site residues [active] 336982010227 zinc binding site [ion binding]; other site 336982010228 GTP-CH-I/GFRP interaction surface; other site 336982010229 FtsH Extracellular; Region: FtsH_ext; pfam06480 336982010230 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 336982010231 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 336982010232 Walker A motif; other site 336982010233 ATP binding site [chemical binding]; other site 336982010234 Walker B motif; other site 336982010235 arginine finger; other site 336982010236 Peptidase family M41; Region: Peptidase_M41; pfam01434 336982010237 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 336982010238 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 336982010239 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 336982010240 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 336982010241 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 336982010242 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 336982010243 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 336982010244 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982010245 PPE family; Region: PPE; pfam00823 336982010246 PE family; Region: PE; pfam00934 336982010247 Uncharacterized conserved protein [Function unknown]; Region: COG2968 336982010248 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 336982010249 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 336982010250 active site 336982010251 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 336982010252 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 336982010253 Ligand Binding Site [chemical binding]; other site 336982010254 Uncharacterized conserved protein [Function unknown]; Region: COG5282 336982010255 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 336982010256 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113 336982010257 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 336982010258 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 336982010259 dimer interface [polypeptide binding]; other site 336982010260 substrate binding site [chemical binding]; other site 336982010261 metal binding sites [ion binding]; metal-binding site 336982010262 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2899 336982010263 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 336982010264 Ligand binding site; other site 336982010265 Putative Catalytic site; other site 336982010266 DXD motif; other site 336982010267 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 336982010268 Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5285 336982010269 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 336982010270 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982010271 NAD(P) binding site [chemical binding]; other site 336982010272 active site 336982010273 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 336982010274 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 336982010275 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 336982010276 transposase; Provisional; Region: PRK06526 336982010277 IstB-like ATP binding protein; Region: IstB_IS21; pfam01695 336982010278 Walker B motif; other site 336982010279 Transposase, Mutator family; Region: Transposase_mut; pfam00872 336982010280 MULE transposase domain; Region: MULE; pfam10551 336982010281 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 336982010282 Fic/DOC family; Region: Fic; cl00960 336982010283 DNA polymerase III subunit delta'; Validated; Region: PRK07940 336982010284 DNA polymerase III subunit delta'; Validated; Region: PRK08485 336982010285 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 336982010286 dimerization interface [polypeptide binding]; other site 336982010287 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 336982010288 cyclase homology domain; Region: CHD; cd07302 336982010289 nucleotidyl binding site; other site 336982010290 metal binding site [ion binding]; metal-binding site 336982010291 dimer interface [polypeptide binding]; other site 336982010292 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 336982010293 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 336982010294 active site 336982010295 interdomain interaction site; other site 336982010296 putative metal-binding site [ion binding]; other site 336982010297 nucleotide binding site [chemical binding]; other site 336982010298 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 336982010299 domain I; other site 336982010300 phosphate binding site [ion binding]; other site 336982010301 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 336982010302 domain II; other site 336982010303 domain III; other site 336982010304 nucleotide binding site [chemical binding]; other site 336982010305 DNA binding groove [nucleotide binding] 336982010306 catalytic site [active] 336982010307 domain IV; other site 336982010308 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 336982010309 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 336982010310 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 336982010311 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 336982010312 DNA-binding site [nucleotide binding]; DNA binding site 336982010313 RNA-binding motif; other site 336982010314 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 336982010315 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 336982010316 ATP binding site [chemical binding]; other site 336982010317 putative Mg++ binding site [ion binding]; other site 336982010318 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 336982010319 nucleotide binding region [chemical binding]; other site 336982010320 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 336982010321 PE family; Region: PE; pfam00934 336982010322 PE family; Region: PE; pfam00934 336982010323 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 336982010324 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 336982010325 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 336982010326 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 336982010327 Walker A motif; other site 336982010328 hexamer interface [polypeptide binding]; other site 336982010329 ATP binding site [chemical binding]; other site 336982010330 Walker B motif; other site 336982010331 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 336982010332 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 336982010333 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 336982010334 motif II; other site 336982010335 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 336982010336 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 336982010337 Walker A/P-loop; other site 336982010338 ATP binding site [chemical binding]; other site 336982010339 Q-loop/lid; other site 336982010340 ABC transporter signature motif; other site 336982010341 Walker B; other site 336982010342 D-loop; other site 336982010343 H-loop/switch region; other site 336982010344 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 336982010345 Walker A/P-loop; other site 336982010346 ATP binding site [chemical binding]; other site 336982010347 Q-loop/lid; other site 336982010348 ABC transporter signature motif; other site 336982010349 Walker B; other site 336982010350 D-loop; other site 336982010351 H-loop/switch region; other site 336982010352 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 336982010353 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 336982010354 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 336982010355 ABC-ATPase subunit interface; other site 336982010356 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 336982010357 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 336982010358 dimer interface [polypeptide binding]; other site 336982010359 conserved gate region; other site 336982010360 ABC-ATPase subunit interface; other site 336982010361 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 336982010362 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 336982010363 acetyl-CoA synthetase; Provisional; Region: PRK00174 336982010364 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 336982010365 active site 336982010366 CoA binding site [chemical binding]; other site 336982010367 acyl-activating enzyme (AAE) consensus motif; other site 336982010368 AMP binding site [chemical binding]; other site 336982010369 acetate binding site [chemical binding]; other site 336982010370 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 336982010371 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 336982010372 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 336982010373 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 336982010374 putative active site [active] 336982010375 putative CoA binding site [chemical binding]; other site 336982010376 nudix motif; other site 336982010377 metal binding site [ion binding]; metal-binding site 336982010378 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 336982010379 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 336982010380 catalytic residues [active] 336982010381 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 336982010382 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 336982010383 minor groove reading motif; other site 336982010384 helix-hairpin-helix signature motif; other site 336982010385 substrate binding pocket [chemical binding]; other site 336982010386 active site 336982010387 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 336982010388 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 336982010389 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 336982010390 ligand binding site [chemical binding]; other site 336982010391 flexible hinge region; other site 336982010392 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 336982010393 putative switch regulator; other site 336982010394 non-specific DNA interactions [nucleotide binding]; other site 336982010395 DNA binding site [nucleotide binding] 336982010396 sequence specific DNA binding site [nucleotide binding]; other site 336982010397 putative cAMP binding site [chemical binding]; other site 336982010398 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 336982010399 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 336982010400 homotrimer interaction site [polypeptide binding]; other site 336982010401 putative active site [active] 336982010402 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 336982010403 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 336982010404 P loop; other site 336982010405 Nucleotide binding site [chemical binding]; other site 336982010406 DTAP/Switch II; other site 336982010407 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 336982010408 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 336982010409 DTAP/Switch II; other site 336982010410 Switch I; other site 336982010411 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 336982010412 Transcription factor WhiB; Region: Whib; pfam02467 336982010413 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 336982010414 Transglycosylase; Region: Transgly; pfam00912 336982010415 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 336982010416 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 336982010417 phosphodiesterase YaeI; Provisional; Region: PRK11340 336982010418 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 336982010419 putative active site [active] 336982010420 putative metal binding site [ion binding]; other site 336982010421 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 336982010422 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 336982010423 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 336982010424 catalytic residue [active] 336982010425 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 336982010426 Cytochrome P450; Region: p450; cl12078 336982010427 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 336982010428 anti sigma factor interaction site; other site 336982010429 regulatory phosphorylation site [posttranslational modification]; other site 336982010430 Uncharacterized conserved protein [Function unknown]; Region: COG1610 336982010431 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 336982010432 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 336982010433 MoxR-like ATPases [General function prediction only]; Region: COG0714 336982010434 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 336982010435 Walker A motif; other site 336982010436 ATP binding site [chemical binding]; other site 336982010437 Walker B motif; other site 336982010438 arginine finger; other site 336982010439 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 336982010440 Protein of unknown function DUF58; Region: DUF58; pfam01882 336982010441 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 336982010442 Predicted membrane protein/domain [Function unknown]; Region: COG1714 336982010443 glycerol kinase; Provisional; Region: glpK; PRK00047 336982010444 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 336982010445 nucleotide binding site [chemical binding]; other site 336982010446 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 336982010447 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 336982010448 Methyltransferase domain; Region: Methyltransf_23; pfam13489 336982010449 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 336982010450 S-adenosylmethionine binding site [chemical binding]; other site 336982010451 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 336982010452 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 336982010453 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 336982010454 catalytic residue [active] 336982010455 Uncharacterized conserved protein [Function unknown]; Region: COG4301 336982010456 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 336982010457 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 336982010458 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 336982010459 putative active site [active] 336982010460 putative dimer interface [polypeptide binding]; other site 336982010461 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 336982010462 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 336982010463 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 336982010464 PknH-like extracellular domain; Region: PknH_C; pfam14032 336982010465 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 336982010466 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 336982010467 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 336982010468 aspartate kinase; Reviewed; Region: PRK06635 336982010469 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 336982010470 putative nucleotide binding site [chemical binding]; other site 336982010471 putative catalytic residues [active] 336982010472 putative Mg ion binding site [ion binding]; other site 336982010473 putative aspartate binding site [chemical binding]; other site 336982010474 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 336982010475 putative allosteric regulatory site; other site 336982010476 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 336982010477 putative allosteric regulatory residue; other site 336982010478 2-isopropylmalate synthase; Validated; Region: PRK03739 336982010479 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 336982010480 active site 336982010481 catalytic residues [active] 336982010482 metal binding site [ion binding]; metal-binding site 336982010483 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 336982010484 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 336982010485 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 336982010486 active site 336982010487 catalytic site [active] 336982010488 substrate binding site [chemical binding]; other site 336982010489 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 336982010490 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 336982010491 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 336982010492 catalytic triad [active] 336982010493 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 336982010494 putative active site [active] 336982010495 recombination protein RecR; Reviewed; Region: recR; PRK00076 336982010496 RecR protein; Region: RecR; pfam02132 336982010497 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 336982010498 putative active site [active] 336982010499 putative metal-binding site [ion binding]; other site 336982010500 tetramer interface [polypeptide binding]; other site 336982010501 hypothetical protein; Validated; Region: PRK00153 336982010502 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 336982010503 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 336982010504 active site 336982010505 metal binding site [ion binding]; metal-binding site 336982010506 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 336982010507 hydrophobic ligand binding site; other site 336982010508 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 336982010509 FAD binding domain; Region: FAD_binding_4; pfam01565 336982010510 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 336982010511 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 336982010512 S-adenosylmethionine binding site [chemical binding]; other site 336982010513 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14952 336982010514 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 336982010515 Walker A motif; other site 336982010516 ATP binding site [chemical binding]; other site 336982010517 Walker B motif; other site 336982010518 arginine finger; other site 336982010519 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 336982010520 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 336982010521 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 336982010522 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 336982010523 catalytic residue [active] 336982010524 Cutinase; Region: Cutinase; pfam01083 336982010525 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982010526 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 336982010527 NAD(P) binding site [chemical binding]; other site 336982010528 active site 336982010529 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 336982010530 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 336982010531 putative NAD(P) binding site [chemical binding]; other site 336982010532 catalytic Zn binding site [ion binding]; other site 336982010533 Uncharacterized conserved protein [Function unknown]; Region: COG3349 336982010534 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 336982010535 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 336982010536 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 336982010537 putative substrate translocation pore; other site 336982010538 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 336982010539 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 336982010540 ligand binding site [chemical binding]; other site 336982010541 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 336982010542 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 336982010543 active site 336982010544 nucleophile elbow; other site 336982010545 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 336982010546 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 336982010547 FeS/SAM binding site; other site 336982010548 Methyltransferase domain; Region: Methyltransf_31; pfam13847 336982010549 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 336982010550 S-adenosylmethionine binding site [chemical binding]; other site 336982010551 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 336982010552 nucleotide binding site [chemical binding]; other site 336982010553 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 336982010554 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 336982010555 active site 336982010556 DNA binding site [nucleotide binding] 336982010557 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 336982010558 DNA binding site [nucleotide binding] 336982010559 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4402 336982010560 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_5; cd04662 336982010561 nudix motif; other site 336982010562 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 336982010563 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 336982010564 Uncharacterized conserved protein [Function unknown]; Region: COG1839 336982010565 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 336982010566 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 336982010567 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 336982010568 Uncharacterized conserved protein [Function unknown]; Region: COG2966 336982010569 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 336982010570 Uncharacterized conserved protein [Function unknown]; Region: COG3610 336982010571 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982010572 PPE family; Region: PPE; pfam00823 336982010573 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982010574 PPE family; Region: PPE; pfam00823 336982010575 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 336982010576 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 336982010577 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 336982010578 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 336982010579 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 336982010580 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 336982010581 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 336982010582 Soluble P-type ATPase [General function prediction only]; Region: COG4087 336982010583 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 336982010584 dimerization interface [polypeptide binding]; other site 336982010585 putative DNA binding site [nucleotide binding]; other site 336982010586 putative Zn2+ binding site [ion binding]; other site 336982010587 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3651 336982010588 DNA binding domain, excisionase family; Region: excise; TIGR01764 336982010589 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 336982010590 active site 336982010591 Int/Topo IB signature motif; other site 336982010592 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 336982010593 nucleoside/Zn binding site; other site 336982010594 dimer interface [polypeptide binding]; other site 336982010595 catalytic motif [active] 336982010596 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 336982010597 prephenate dehydrogenase; Validated; Region: PRK06545 336982010598 prephenate dehydrogenase; Validated; Region: PRK08507 336982010599 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3554 336982010600 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 336982010601 ABC-ATPase subunit interface; other site 336982010602 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 336982010603 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 336982010604 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 336982010605 Walker A/P-loop; other site 336982010606 ATP binding site [chemical binding]; other site 336982010607 Q-loop/lid; other site 336982010608 ABC transporter signature motif; other site 336982010609 Walker B; other site 336982010610 D-loop; other site 336982010611 H-loop/switch region; other site 336982010612 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 336982010613 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 336982010614 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 336982010615 putative active site [active] 336982010616 putative substrate binding site [chemical binding]; other site 336982010617 ATP binding site [chemical binding]; other site 336982010618 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 336982010619 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 336982010620 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 336982010621 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 336982010622 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 336982010623 dimerization interface [polypeptide binding]; other site 336982010624 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 336982010625 dimer interface [polypeptide binding]; other site 336982010626 phosphorylation site [posttranslational modification] 336982010627 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 336982010628 ATP binding site [chemical binding]; other site 336982010629 Mg2+ binding site [ion binding]; other site 336982010630 G-X-G motif; other site 336982010631 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 336982010632 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 336982010633 active site 336982010634 phosphorylation site [posttranslational modification] 336982010635 intermolecular recognition site; other site 336982010636 dimerization interface [polypeptide binding]; other site 336982010637 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 336982010638 DNA binding site [nucleotide binding] 336982010639 Photosystem II reaction centre W protein (PsbW); Region: PsbW; cl06243 336982010640 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 336982010641 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 336982010642 SnoaL-like domain; Region: SnoaL_2; pfam12680 336982010643 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 336982010644 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 336982010645 pyridoxal 5'-phosphate binding site [chemical binding]; other site 336982010646 homodimer interface [polypeptide binding]; other site 336982010647 catalytic residue [active] 336982010648 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 336982010649 TIGR03086 family protein; Region: TIGR03086 336982010650 enoyl-CoA hydratase; Provisional; Region: PRK06142 336982010651 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 336982010652 substrate binding site [chemical binding]; other site 336982010653 oxyanion hole (OAH) forming residues; other site 336982010654 trimer interface [polypeptide binding]; other site 336982010655 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 336982010656 Beta-lactamase; Region: Beta-lactamase; pfam00144 336982010657 Domain of unknown function (DUF222); Region: DUF222; pfam02720 336982010658 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 336982010659 active site 336982010660 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 336982010661 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 336982010662 NAD(P) binding site [chemical binding]; other site 336982010663 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 336982010664 cysteine desulfurase family protein, VC1184 subfamily; Region: am_tr_V_VC1184; TIGR01976 336982010665 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 336982010666 catalytic residue [active] 336982010667 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 336982010668 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 336982010669 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 336982010670 Walker A/P-loop; other site 336982010671 ATP binding site [chemical binding]; other site 336982010672 Q-loop/lid; other site 336982010673 ABC transporter signature motif; other site 336982010674 Walker B; other site 336982010675 D-loop; other site 336982010676 H-loop/switch region; other site 336982010677 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 336982010678 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 336982010679 active site 336982010680 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 336982010681 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 336982010682 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 336982010683 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 336982010684 NAD binding site [chemical binding]; other site 336982010685 substrate binding site [chemical binding]; other site 336982010686 active site 336982010687 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 336982010688 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 336982010689 active site 336982010690 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 336982010691 Peptidase family M23; Region: Peptidase_M23; pfam01551 336982010692 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 336982010693 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 336982010694 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05892 336982010695 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 336982010696 Predicted membrane protein [Function unknown]; Region: COG2246 336982010697 GtrA-like protein; Region: GtrA; pfam04138 336982010698 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 336982010699 FAD binding domain; Region: FAD_binding_4; pfam01565 336982010700 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 336982010701 short chain dehydrogenase; Provisional; Region: PRK07904 336982010702 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 336982010703 NAD(P) binding site [chemical binding]; other site 336982010704 active site 336982010705 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 336982010706 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 336982010707 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 336982010708 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 336982010709 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 336982010710 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 336982010711 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 336982010712 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 336982010713 FAD binding site [chemical binding]; other site 336982010714 substrate binding site [chemical binding]; other site 336982010715 catalytic residues [active] 336982010716 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 336982010717 Transposase; Region: DDE_Tnp_ISL3; pfam01610 336982010718 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 336982010719 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 336982010720 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 336982010721 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 336982010722 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 336982010723 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 336982010724 active site 336982010725 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 336982010726 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 336982010727 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 336982010728 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 336982010729 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 336982010730 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 336982010731 acyl-activating enzyme (AAE) consensus motif; other site 336982010732 active site 336982010733 Cutinase; Region: Cutinase; pfam01083 336982010734 Predicted esterase [General function prediction only]; Region: COG0627 336982010735 Putative esterase; Region: Esterase; pfam00756 336982010736 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 336982010737 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 336982010738 active site 336982010739 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 336982010740 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 336982010741 active site 336982010742 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 336982010743 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 336982010744 UDP-galactopyranose mutase; Region: GLF; pfam03275 336982010745 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 336982010746 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 336982010747 amidase catalytic site [active] 336982010748 Zn binding residues [ion binding]; other site 336982010749 substrate binding site [chemical binding]; other site 336982010750 LGFP repeat; Region: LGFP; pfam08310 336982010751 PE family; Region: PE; pfam00934 336982010752 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 336982010753 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 336982010754 active site 336982010755 motif I; other site 336982010756 motif II; other site 336982010757 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 336982010758 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 336982010759 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 336982010760 putative acyl-acceptor binding pocket; other site 336982010761 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 336982010762 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 336982010763 putative acyl-acceptor binding pocket; other site 336982010764 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 336982010765 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 336982010766 putative acyl-acceptor binding pocket; other site 336982010767 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 336982010768 Phosphotransferase enzyme family; Region: APH; pfam01636 336982010769 active site 336982010770 ATP binding site [chemical binding]; other site 336982010771 antibiotic binding site [chemical binding]; other site 336982010772 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 336982010773 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 336982010774 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 336982010775 iron-sulfur cluster [ion binding]; other site 336982010776 [2Fe-2S] cluster binding site [ion binding]; other site 336982010777 Condensation domain; Region: Condensation; pfam00668 336982010778 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 336982010779 PE-PPE domain; Region: PE-PPE; pfam08237 336982010780 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 336982010781 Condensation domain; Region: Condensation; pfam00668 336982010782 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 336982010783 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 336982010784 active site 336982010785 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 336982010786 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 336982010787 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982010788 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 336982010789 Enoylreductase; Region: PKS_ER; smart00829 336982010790 NAD(P) binding site [chemical binding]; other site 336982010791 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 336982010792 KR domain; Region: KR; pfam08659 336982010793 putative NADP binding site [chemical binding]; other site 336982010794 active site 336982010795 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 336982010796 acyl-CoA synthetase; Validated; Region: PRK05850 336982010797 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 336982010798 acyl-activating enzyme (AAE) consensus motif; other site 336982010799 active site 336982010800 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 336982010801 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 336982010802 Probable transposase; Region: OrfB_IS605; pfam01385 336982010803 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 336982010804 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 336982010805 catalytic residues [active] 336982010806 catalytic nucleophile [active] 336982010807 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 336982010808 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 336982010809 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 336982010810 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982010811 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 336982010812 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 336982010813 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 336982010814 Cupin domain; Region: Cupin_2; cl17218 336982010815 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 336982010816 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 336982010817 seryl-tRNA synthetase; Provisional; Region: PRK05431 336982010818 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 336982010819 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 336982010820 dimer interface [polypeptide binding]; other site 336982010821 active site 336982010822 motif 1; other site 336982010823 motif 2; other site 336982010824 motif 3; other site 336982010825 Septum formation; Region: Septum_form; pfam13845 336982010826 Septum formation; Region: Septum_form; pfam13845 336982010827 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 336982010828 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 336982010829 catalytic core [active] 336982010830 prephenate dehydratase; Provisional; Region: PRK11898 336982010831 Prephenate dehydratase; Region: PDT; pfam00800 336982010832 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 336982010833 putative L-Phe binding site [chemical binding]; other site 336982010834 Transcriptional regulator [Transcription]; Region: LytR; COG1316 336982010835 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 336982010836 Ferritin-like domain; Region: Ferritin; pfam00210 336982010837 ferroxidase diiron center [ion binding]; other site 336982010838 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 336982010839 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 336982010840 putative active site [active] 336982010841 catalytic site [active] 336982010842 putative metal binding site [ion binding]; other site 336982010843 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 336982010844 Transposase; Region: DEDD_Tnp_IS110; pfam01548 336982010845 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 336982010846 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 336982010847 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 336982010848 Predicted membrane protein [Function unknown]; Region: COG2119 336982010849 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 336982010850 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 336982010851 Fimbrial protein; Region: Fimbrial; cl01416 336982010852 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 336982010853 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 336982010854 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 336982010855 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982010856 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982010857 hypothetical protein; Provisional; Region: PRK07945 336982010858 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 336982010859 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 336982010860 active site 336982010861 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 336982010862 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 336982010863 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 336982010864 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 336982010865 active site 336982010866 dimer interface [polypeptide binding]; other site 336982010867 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 336982010868 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 336982010869 active site 336982010870 FMN binding site [chemical binding]; other site 336982010871 substrate binding site [chemical binding]; other site 336982010872 3Fe-4S cluster binding site [ion binding]; other site 336982010873 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 336982010874 domain interface; other site 336982010875 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 336982010876 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 336982010877 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 336982010878 EspG family; Region: ESX-1_EspG; pfam14011 336982010879 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 336982010880 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 336982010881 Walker A motif; other site 336982010882 ATP binding site [chemical binding]; other site 336982010883 Walker B motif; other site 336982010884 arginine finger; other site 336982010885 Protein of unknown function (DUF690); Region: DUF690; pfam05108 336982010886 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 336982010887 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 336982010888 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 336982010889 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 336982010890 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 336982010891 PE family; Region: PE; pfam00934 336982010892 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982010893 PPE family; Region: PPE; pfam00823 336982010894 Proteins of 100 residues with WXG; Region: WXG100; cl02005 336982010895 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 336982010896 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 336982010897 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 336982010898 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 336982010899 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 336982010900 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 336982010901 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 336982010902 active site 336982010903 catalytic residues [active] 336982010904 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 336982010905 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 336982010906 Walker A motif; other site 336982010907 ATP binding site [chemical binding]; other site 336982010908 Walker B motif; other site 336982010909 arginine finger; other site 336982010910 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 336982010911 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 336982010912 catalytic residues [active] 336982010913 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 336982010914 active site 336982010915 catalytic residues [active] 336982010916 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 336982010917 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 336982010918 EspG family; Region: ESX-1_EspG; pfam14011 336982010919 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 336982010920 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 336982010921 PPE family; Region: PPE; pfam00823 336982010922 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 336982010923 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 336982010924 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 336982010925 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 336982010926 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 336982010927 Protein of unknown function (DUF690); Region: DUF690; pfam05108 336982010928 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 336982010929 N-acetyl-D-glucosamine binding site [chemical binding]; other site 336982010930 catalytic residue [active] 336982010931 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 336982010932 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 336982010933 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 336982010934 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 336982010935 active site 336982010936 NTP binding site [chemical binding]; other site 336982010937 metal binding triad [ion binding]; metal-binding site 336982010938 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 336982010939 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 336982010940 Zn2+ binding site [ion binding]; other site 336982010941 Mg2+ binding site [ion binding]; other site 336982010942 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 336982010943 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 336982010944 active site 336982010945 Ap6A binding site [chemical binding]; other site 336982010946 nudix motif; other site 336982010947 metal binding site [ion binding]; metal-binding site 336982010948 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 336982010949 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 336982010950 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 336982010951 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 336982010952 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 336982010953 DNA binding residues [nucleotide binding] 336982010954 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 336982010955 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 336982010956 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 336982010957 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 336982010958 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 336982010959 catalytic residues [active] 336982010960 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 336982010961 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 336982010962 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 336982010963 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 336982010964 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 336982010965 active site 336982010966 metal binding site [ion binding]; metal-binding site 336982010967 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 336982010968 ParB-like nuclease domain; Region: ParB; smart00470 336982010969 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 336982010970 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 336982010971 P-loop; other site 336982010972 Magnesium ion binding site [ion binding]; other site 336982010973 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 336982010974 Magnesium ion binding site [ion binding]; other site 336982010975 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 336982010976 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 336982010977 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 336982010978 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 336982010979 G-X-X-G motif; other site 336982010980 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 336982010981 RxxxH motif; other site 336982010982 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 336982010983 Uncharacterized conserved protein [Function unknown]; Region: COG0759 336982010984 ribonuclease P; Reviewed; Region: rnpA; PRK00588 336982010985 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399