-- dump date 20140619_154557 -- class Genbank::misc_feature -- table misc_feature_note -- id note 419947000001 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 419947000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 419947000003 Walker A motif; other site 419947000004 ATP binding site [chemical binding]; other site 419947000005 Walker B motif; other site 419947000006 arginine finger; other site 419947000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 419947000008 DnaA box-binding interface [nucleotide binding]; other site 419947000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 419947000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 419947000011 putative DNA binding surface [nucleotide binding]; other site 419947000012 dimer interface [polypeptide binding]; other site 419947000013 beta-clamp/clamp loader binding surface; other site 419947000014 beta-clamp/translesion DNA polymerase binding surface; other site 419947000015 recF protein; Region: recf; TIGR00611 419947000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 419947000017 Walker A/P-loop; other site 419947000018 ATP binding site [chemical binding]; other site 419947000019 Q-loop/lid; other site 419947000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 419947000021 ABC transporter signature motif; other site 419947000022 Walker B; other site 419947000023 D-loop; other site 419947000024 H-loop/switch region; other site 419947000025 hypothetical protein; Provisional; Region: PRK03195 419947000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 419947000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 419947000028 Mg2+ binding site [ion binding]; other site 419947000029 G-X-G motif; other site 419947000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 419947000031 anchoring element; other site 419947000032 dimer interface [polypeptide binding]; other site 419947000033 ATP binding site [chemical binding]; other site 419947000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 419947000035 active site 419947000036 putative metal-binding site [ion binding]; other site 419947000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 419947000038 DNA gyrase subunit A; Validated; Region: PRK05560 419947000039 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 419947000040 CAP-like domain; other site 419947000041 active site 419947000042 primary dimer interface [polypeptide binding]; other site 419947000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 419947000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 419947000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 419947000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 419947000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 419947000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 419947000049 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 419947000050 Protein of unknown function (DUF2562); Region: DUF2562; pfam10814 419947000051 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 419947000052 active site 419947000053 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 419947000054 putative transposase OrfB; Reviewed; Region: PHA02517 419947000055 HTH-like domain; Region: HTH_21; pfam13276 419947000056 Integrase core domain; Region: rve; pfam00665 419947000057 Integrase core domain; Region: rve_3; pfam13683 419947000058 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 419947000059 Transposase; Region: HTH_Tnp_1; cl17663 419947000060 putative septation inhibitor protein; Reviewed; Region: PRK00159 419947000061 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 419947000062 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 419947000063 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 419947000064 Glutamine amidotransferase class-I; Region: GATase; pfam00117 419947000065 glutamine binding [chemical binding]; other site 419947000066 catalytic triad [active] 419947000067 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 419947000068 Catalytic domain of Protein Kinases; Region: PKc; cd00180 419947000069 active site 419947000070 ATP binding site [chemical binding]; other site 419947000071 substrate binding site [chemical binding]; other site 419947000072 activation loop (A-loop); other site 419947000073 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 419947000074 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 419947000075 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 419947000076 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 419947000077 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 419947000078 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 419947000079 Catalytic domain of Protein Kinases; Region: PKc; cd00180 419947000080 active site 419947000081 ATP binding site [chemical binding]; other site 419947000082 substrate binding site [chemical binding]; other site 419947000083 activation loop (A-loop); other site 419947000084 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 419947000085 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 419947000086 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 419947000087 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 419947000088 active site 419947000089 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 419947000090 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 419947000091 phosphopeptide binding site; other site 419947000092 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 419947000093 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 419947000094 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 419947000095 phosphopeptide binding site; other site 419947000096 Nitronate monooxygenase; Region: NMO; pfam03060 419947000097 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 419947000098 FMN binding site [chemical binding]; other site 419947000099 substrate binding site [chemical binding]; other site 419947000100 putative catalytic residue [active] 419947000101 Transcription factor WhiB; Region: Whib; pfam02467 419947000102 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 419947000103 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 419947000104 non-specific DNA binding site [nucleotide binding]; other site 419947000105 salt bridge; other site 419947000106 sequence-specific DNA binding site [nucleotide binding]; other site 419947000107 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 419947000108 NlpC/P60 family; Region: NLPC_P60; pfam00877 419947000109 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 419947000110 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 419947000111 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 419947000112 Protein of unknown function (DUF2694); Region: DUF2694; pfam10904 419947000113 Protein of unknown function (DUF2710); Region: DUF2710; pfam10921 419947000114 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 419947000115 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 419947000116 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 419947000117 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 419947000118 catalytic residue [active] 419947000119 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 419947000120 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 419947000121 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 419947000122 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 419947000123 acyl-activating enzyme (AAE) consensus motif; other site 419947000124 active site 419947000125 TIGR03084 family protein; Region: TIGR03084 419947000126 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 419947000127 Wyosine base formation; Region: Wyosine_form; pfam08608 419947000128 H+ Antiporter protein; Region: 2A0121; TIGR00900 419947000129 hypothetical protein; Validated; Region: PRK00228 419947000130 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 419947000131 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 419947000132 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 419947000133 active site 419947000134 HIGH motif; other site 419947000135 nucleotide binding site [chemical binding]; other site 419947000136 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 419947000137 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 419947000138 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 419947000139 active site 419947000140 KMSKS motif; other site 419947000141 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 419947000142 tRNA binding surface [nucleotide binding]; other site 419947000143 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 419947000144 MarR family; Region: MarR; pfam01047 419947000145 Transcriptional regulators [Transcription]; Region: FadR; COG2186 419947000146 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 419947000147 DNA-binding site [nucleotide binding]; DNA binding site 419947000148 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 419947000149 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 419947000150 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 419947000151 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 419947000152 inositol 1-phosphate synthase, Actinobacterial type; Region: mycothiol_INO1; TIGR03450 419947000153 Predicted transcriptional regulators [Transcription]; Region: COG1695 419947000154 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 419947000155 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 419947000156 Transglycosylase; Region: Transgly; pfam00912 419947000157 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 419947000158 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 419947000159 Predicted integral membrane protein [Function unknown]; Region: COG5650 419947000160 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 419947000161 conserved cys residue [active] 419947000162 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 419947000163 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 419947000164 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 419947000165 dimer interface [polypeptide binding]; other site 419947000166 ssDNA binding site [nucleotide binding]; other site 419947000167 tetramer (dimer of dimers) interface [polypeptide binding]; other site 419947000168 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 419947000169 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 419947000170 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 419947000171 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 419947000172 replicative DNA helicase; Validated; Region: PRK07773 419947000173 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 419947000174 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 419947000175 Walker A motif; other site 419947000176 ATP binding site [chemical binding]; other site 419947000177 Walker B motif; other site 419947000178 DNA binding loops [nucleotide binding] 419947000179 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 419947000180 protein-splicing catalytic site; other site 419947000181 thioester formation/cholesterol transfer; other site 419947000182 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 419947000183 protein-splicing catalytic site; other site 419947000184 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 419947000185 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 419947000186 ADP-ribose binding site [chemical binding]; other site 419947000187 Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1 [General function prediction only]; Region: COG2110 419947000188 Cellobiohydrolase A (1,4-beta-cellobiosidase A) [Carbohydrate transport and metabolism]; Region: CelA; COG5297 419947000189 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 419947000190 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 419947000191 FAD binding domain; Region: FAD_binding_4; pfam01565 419947000192 Berberine and berberine like; Region: BBE; pfam08031 419947000193 hypothetical protein; Provisional; Region: PRK12438 419947000194 hypothetical protein; Validated; Region: PRK00068 419947000195 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 419947000196 homotetrameric interface [polypeptide binding]; other site 419947000197 putative active site [active] 419947000198 metal binding site [ion binding]; metal-binding site 419947000199 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 419947000200 Monomeric isocitrate dehydrogenase; Region: IDH; pfam03971 419947000201 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 419947000202 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 419947000203 short chain dehydrogenase; Provisional; Region: PRK06197 419947000204 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 419947000205 putative NAD(P) binding site [chemical binding]; other site 419947000206 active site 419947000207 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 419947000208 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 419947000209 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 419947000210 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 419947000211 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 419947000212 dimer interface [polypeptide binding]; other site 419947000213 active site 419947000214 glycine-pyridoxal phosphate binding site [chemical binding]; other site 419947000215 folate binding site [chemical binding]; other site 419947000216 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 419947000217 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 419947000218 putative NTP binding site [chemical binding]; other site 419947000219 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 419947000220 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 419947000221 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 419947000222 Walker A/P-loop; other site 419947000223 ATP binding site [chemical binding]; other site 419947000224 Q-loop/lid; other site 419947000225 ABC transporter signature motif; other site 419947000226 Walker B; other site 419947000227 D-loop; other site 419947000228 H-loop/switch region; other site 419947000229 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 419947000230 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 419947000231 ligand binding site [chemical binding]; other site 419947000232 flexible hinge region; other site 419947000233 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 419947000234 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 419947000235 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 419947000236 active site 419947000237 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 419947000238 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 419947000239 pyridoxal 5'-phosphate binding site [chemical binding]; other site 419947000240 homodimer interface [polypeptide binding]; other site 419947000241 catalytic residue [active] 419947000242 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 419947000243 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 419947000244 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 419947000245 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 419947000246 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 419947000247 dimerization interface [polypeptide binding]; other site 419947000248 putative DNA binding site [nucleotide binding]; other site 419947000249 putative Zn2+ binding site [ion binding]; other site 419947000250 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 419947000251 hydrogenase 4 subunit B; Validated; Region: PRK06521 419947000252 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 419947000253 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 419947000254 NADH dehydrogenase; Region: NADHdh; cl00469 419947000255 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; COG4237 419947000256 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 419947000257 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 419947000258 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 419947000259 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 419947000260 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 419947000261 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 419947000262 putative hydrophobic ligand binding site [chemical binding]; other site 419947000263 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 419947000264 S-adenosylmethionine binding site [chemical binding]; other site 419947000265 Predicted membrane protein [Function unknown]; Region: COG3305 419947000266 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 419947000267 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 419947000268 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 419947000269 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 419947000270 metal-binding site [ion binding] 419947000271 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 419947000272 Soluble P-type ATPase [General function prediction only]; Region: COG4087 419947000273 Predicted integral membrane protein [Function unknown]; Region: COG5660 419947000274 Putative zinc-finger; Region: zf-HC2; pfam13490 419947000275 Domain of unknown function (DUF222); Region: DUF222; pfam02720 419947000276 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 419947000277 active site 419947000278 Domain of unknown function (DUF222); Region: DUF222; pfam02720 419947000279 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947000280 PPE family; Region: PPE; pfam00823 419947000281 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 419947000282 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 419947000283 FcoT-like thioesterase domain; Region: FcoT; pfam10862 419947000284 acyl-CoA synthetase; Validated; Region: PRK05857 419947000285 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 419947000286 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 419947000287 acyl-activating enzyme (AAE) consensus motif; other site 419947000288 acyl-activating enzyme (AAE) consensus motif; other site 419947000289 AMP binding site [chemical binding]; other site 419947000290 active site 419947000291 CoA binding site [chemical binding]; other site 419947000292 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 419947000293 AMP-binding enzyme; Region: AMP-binding; pfam00501 419947000294 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 419947000295 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 419947000296 acyl-activating enzyme (AAE) consensus motif; other site 419947000297 acyl-activating enzyme (AAE) consensus motif; other site 419947000298 active site 419947000299 AMP binding site [chemical binding]; other site 419947000300 CoA binding site [chemical binding]; other site 419947000301 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 419947000302 Condensation domain; Region: Condensation; pfam00668 419947000303 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 419947000304 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 419947000305 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 419947000306 acyl-activating enzyme (AAE) consensus motif; other site 419947000307 AMP binding site [chemical binding]; other site 419947000308 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 419947000309 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 419947000310 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 419947000311 putative NAD(P) binding site [chemical binding]; other site 419947000312 active site 419947000313 putative substrate binding site [chemical binding]; other site 419947000314 Predicted membrane protein [Function unknown]; Region: COG3336 419947000315 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 419947000316 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 419947000317 metal-binding site [ion binding] 419947000318 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 419947000319 Soluble P-type ATPase [General function prediction only]; Region: COG4087 419947000320 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 419947000321 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 419947000322 ligand binding site [chemical binding]; other site 419947000323 flexible hinge region; other site 419947000324 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 419947000325 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 419947000326 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 419947000327 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 419947000328 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 419947000329 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 419947000330 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 419947000331 motif II; other site 419947000332 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 419947000333 PE family; Region: PE; pfam00934 419947000334 Rhomboid family; Region: Rhomboid; pfam01694 419947000335 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 419947000336 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 419947000337 active site 419947000338 catalytic triad [active] 419947000339 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 419947000340 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 419947000341 NADP-binding site; other site 419947000342 homotetramer interface [polypeptide binding]; other site 419947000343 substrate binding site [chemical binding]; other site 419947000344 homodimer interface [polypeptide binding]; other site 419947000345 active site 419947000346 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 419947000347 dimer interface [polypeptide binding]; other site 419947000348 active site 419947000349 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 419947000350 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 419947000351 active site 419947000352 motif I; other site 419947000353 motif II; other site 419947000354 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 419947000355 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 419947000356 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 419947000357 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 419947000358 Transcriptional regulator [Transcription]; Region: LysR; COG0583 419947000359 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 419947000360 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 419947000361 dimerization interface [polypeptide binding]; other site 419947000362 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 419947000363 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 419947000364 PYR/PP interface [polypeptide binding]; other site 419947000365 dimer interface [polypeptide binding]; other site 419947000366 TPP binding site [chemical binding]; other site 419947000367 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 419947000368 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 419947000369 TPP-binding site; other site 419947000370 dimer interface [polypeptide binding]; other site 419947000371 acyl-CoA synthetase; Validated; Region: PRK05852 419947000372 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 419947000373 Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926 419947000374 acyl-activating enzyme (AAE) consensus motif; other site 419947000375 acyl-activating enzyme (AAE) consensus motif; other site 419947000376 putative AMP binding site [chemical binding]; other site 419947000377 putative active site [active] 419947000378 putative CoA binding site [chemical binding]; other site 419947000379 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 419947000380 elongation factor G; Reviewed; Region: PRK12740 419947000381 G1 box; other site 419947000382 putative GEF interaction site [polypeptide binding]; other site 419947000383 GTP/Mg2+ binding site [chemical binding]; other site 419947000384 Switch I region; other site 419947000385 G2 box; other site 419947000386 G3 box; other site 419947000387 Switch II region; other site 419947000388 G4 box; other site 419947000389 G5 box; other site 419947000390 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 419947000391 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 419947000392 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 419947000393 PPOX class probable F420-dependent enzyme, Rv0121 family; Region: Rv0121_F420; TIGR03668 419947000394 PE family; Region: PE; pfam00934 419947000395 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 419947000396 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 419947000397 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 419947000398 trehalose synthase; Region: treS_nterm; TIGR02456 419947000399 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 419947000400 active site 419947000401 catalytic site [active] 419947000402 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 419947000403 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 419947000404 Predicted membrane protein [Function unknown]; Region: COG3619 419947000405 Predicted esterase [General function prediction only]; Region: COG0627 419947000406 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 419947000407 putative active site [active] 419947000408 putative catalytic site [active] 419947000409 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 419947000410 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 419947000411 active site 419947000412 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 419947000413 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 419947000414 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 419947000415 Coenzyme A binding pocket [chemical binding]; other site 419947000416 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 419947000417 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 419947000418 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 419947000419 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 419947000420 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 419947000421 Cytochrome P450; Region: p450; cl12078 419947000422 methionine sulfoxide reductase A; Provisional; Region: PRK14054 419947000423 SnoaL-like domain; Region: SnoaL_2; pfam12680 419947000424 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 419947000425 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 419947000426 NAD(P) binding site [chemical binding]; other site 419947000427 active site 419947000428 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 419947000429 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 419947000430 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 419947000431 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 419947000432 minor groove reading motif; other site 419947000433 helix-hairpin-helix signature motif; other site 419947000434 active site 419947000435 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 419947000436 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 419947000437 Cl- selectivity filter; other site 419947000438 Cl- binding residues [ion binding]; other site 419947000439 pore gating glutamate residue; other site 419947000440 dimer interface [polypeptide binding]; other site 419947000441 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 419947000442 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 419947000443 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 419947000444 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 419947000445 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 419947000446 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 419947000447 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 419947000448 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 419947000449 NAD(P) binding site [chemical binding]; other site 419947000450 catalytic residues [active] 419947000451 short chain dehydrogenase; Provisional; Region: PRK07791 419947000452 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 419947000453 NAD binding site [chemical binding]; other site 419947000454 homodimer interface [polypeptide binding]; other site 419947000455 active site 419947000456 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 419947000457 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 419947000458 NAD(P) binding site [chemical binding]; other site 419947000459 PE family; Region: PE; pfam00934 419947000460 PE-PPE domain; Region: PE-PPE; pfam08237 419947000461 PE-PPE domain; Region: PE-PPE; pfam08237 419947000462 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 419947000463 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 419947000464 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 419947000465 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 419947000466 FAD binding site [chemical binding]; other site 419947000467 substrate binding site [chemical binding]; other site 419947000468 catalytic base [active] 419947000469 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 419947000470 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 419947000471 ligand binding site [chemical binding]; other site 419947000472 homodimer interface [polypeptide binding]; other site 419947000473 NAD(P) binding site [chemical binding]; other site 419947000474 trimer interface B [polypeptide binding]; other site 419947000475 trimer interface A [polypeptide binding]; other site 419947000476 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 419947000477 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 419947000478 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 419947000479 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 419947000480 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 419947000481 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 419947000482 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 419947000483 PE family; Region: PE; pfam00934 419947000484 PE-PPE domain; Region: PE-PPE; pfam08237 419947000485 PE family; Region: PE; pfam00934 419947000486 PE-PPE domain; Region: PE-PPE; pfam08237 419947000487 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 419947000488 FAD binding domain; Region: FAD_binding_4; pfam01565 419947000489 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 419947000490 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 419947000491 NAD(P) binding site [chemical binding]; other site 419947000492 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 419947000493 active site 419947000494 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 419947000495 putative hydrophobic ligand binding site [chemical binding]; other site 419947000496 Transcriptional regulators [Transcription]; Region: GntR; COG1802 419947000497 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 419947000498 DNA-binding site [nucleotide binding]; DNA binding site 419947000499 FCD domain; Region: FCD; pfam07729 419947000500 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786 419947000501 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 419947000502 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 419947000503 acyl-activating enzyme (AAE) consensus motif; other site 419947000504 acyl-activating enzyme (AAE) consensus motif; other site 419947000505 putative AMP binding site [chemical binding]; other site 419947000506 putative active site [active] 419947000507 putative CoA binding site [chemical binding]; other site 419947000508 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 419947000509 Permease; Region: Permease; pfam02405 419947000510 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 419947000511 Permease; Region: Permease; pfam02405 419947000512 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 419947000513 mce related protein; Region: MCE; pfam02470 419947000514 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 419947000515 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 419947000516 mce related protein; Region: MCE; pfam02470 419947000517 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 419947000518 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 419947000519 mce related protein; Region: MCE; pfam02470 419947000520 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 419947000521 mce related protein; Region: MCE; pfam02470 419947000522 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 419947000523 mce related protein; Region: MCE; pfam02470 419947000524 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 419947000525 mce related protein; Region: MCE; pfam02470 419947000526 RDD family; Region: RDD; pfam06271 419947000527 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 419947000528 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 419947000529 Predicted membrane protein [Function unknown]; Region: COG1511 419947000530 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 419947000531 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 419947000532 Pirin-related protein [General function prediction only]; Region: COG1741 419947000533 Pirin; Region: Pirin; pfam02678 419947000534 RNA polymerase factor sigma-70; Validated; Region: PRK08241 419947000535 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 419947000536 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 419947000537 DNA binding residues [nucleotide binding] 419947000538 SnoaL-like domain; Region: SnoaL_2; pfam12680 419947000539 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 419947000540 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 419947000541 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 419947000542 putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185 419947000543 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 419947000544 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 419947000545 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 419947000546 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 419947000547 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 419947000548 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 419947000549 S-adenosylmethionine binding site [chemical binding]; other site 419947000550 SPW repeat; Region: SPW; pfam03779 419947000551 SPW repeat; Region: SPW; pfam03779 419947000552 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 419947000553 6-phosphogluconate dehydratase; Region: edd; TIGR01196 419947000554 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 419947000555 putative homodimer interface [polypeptide binding]; other site 419947000556 putative homotetramer interface [polypeptide binding]; other site 419947000557 putative allosteric switch controlling residues; other site 419947000558 putative metal binding site [ion binding]; other site 419947000559 putative homodimer-homodimer interface [polypeptide binding]; other site 419947000560 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 419947000561 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 419947000562 putative substrate translocation pore; other site 419947000563 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 419947000564 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 419947000565 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 419947000566 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 419947000567 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 419947000568 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 419947000569 Walker A/P-loop; other site 419947000570 ATP binding site [chemical binding]; other site 419947000571 Q-loop/lid; other site 419947000572 ABC transporter signature motif; other site 419947000573 Walker B; other site 419947000574 D-loop; other site 419947000575 H-loop/switch region; other site 419947000576 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 419947000577 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 419947000578 Walker A/P-loop; other site 419947000579 ATP binding site [chemical binding]; other site 419947000580 Q-loop/lid; other site 419947000581 ABC transporter signature motif; other site 419947000582 Walker B; other site 419947000583 D-loop; other site 419947000584 H-loop/switch region; other site 419947000585 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 419947000586 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 419947000587 dimerization interface [polypeptide binding]; other site 419947000588 DNA binding residues [nucleotide binding] 419947000589 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 419947000590 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 419947000591 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 419947000592 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 419947000593 putative [Fe4-S4] binding site [ion binding]; other site 419947000594 putative molybdopterin cofactor binding site [chemical binding]; other site 419947000595 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 419947000596 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 419947000597 putative molybdopterin cofactor binding site; other site 419947000598 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 419947000599 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 419947000600 active site 419947000601 Zn binding site [ion binding]; other site 419947000602 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 419947000603 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 419947000604 Predicted integral membrane protein [Function unknown]; Region: COG0392 419947000605 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 419947000606 Domain of unknown function DUF20; Region: UPF0118; pfam01594 419947000607 MMPL family; Region: MMPL; pfam03176 419947000608 MMPL family; Region: MMPL; pfam03176 419947000609 LabA_like proteins; Region: LabA_like; cd06167 419947000610 putative metal binding site [ion binding]; other site 419947000611 Putative methyltransferase; Region: Methyltransf_4; pfam02390 419947000612 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 419947000613 active site 419947000614 substrate-binding site [chemical binding]; other site 419947000615 metal-binding site [ion binding] 419947000616 GTP binding site [chemical binding]; other site 419947000617 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 419947000618 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 419947000619 active site 419947000620 (T/H)XGH motif; other site 419947000621 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 419947000622 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 419947000623 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 419947000624 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 419947000625 FeS/SAM binding site; other site 419947000626 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 419947000627 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 419947000628 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 419947000629 acyl-activating enzyme (AAE) consensus motif; other site 419947000630 acyl-activating enzyme (AAE) consensus motif; other site 419947000631 putative AMP binding site [chemical binding]; other site 419947000632 putative active site [active] 419947000633 putative CoA binding site [chemical binding]; other site 419947000634 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 419947000635 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 419947000636 active site 419947000637 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 419947000638 putative active site [active] 419947000639 putative catalytic site [active] 419947000640 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 419947000641 active site 2 [active] 419947000642 active site 1 [active] 419947000643 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 419947000644 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 419947000645 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 419947000646 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321 419947000647 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 419947000648 Moco binding site; other site 419947000649 metal coordination site [ion binding]; other site 419947000650 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 419947000651 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 419947000652 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 419947000653 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 419947000654 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 419947000655 enoyl-CoA hydratase; Provisional; Region: PRK08252 419947000656 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 419947000657 substrate binding site [chemical binding]; other site 419947000658 oxyanion hole (OAH) forming residues; other site 419947000659 trimer interface [polypeptide binding]; other site 419947000660 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 419947000661 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 419947000662 NAD binding site [chemical binding]; other site 419947000663 catalytic residues [active] 419947000664 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 419947000665 S-adenosylmethionine binding site [chemical binding]; other site 419947000666 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 419947000667 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 419947000668 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 419947000669 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 419947000670 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 419947000671 putative active site [active] 419947000672 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 419947000673 active site 419947000674 substrate binding pocket [chemical binding]; other site 419947000675 homodimer interaction site [polypeptide binding]; other site 419947000676 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 419947000677 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 419947000678 active site 419947000679 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 419947000680 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 419947000681 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 419947000682 active site 419947000683 diiron metal binding site [ion binding]; other site 419947000684 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 419947000685 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 419947000686 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 419947000687 NAD(P) binding site [chemical binding]; other site 419947000688 catalytic residues [active] 419947000689 Lipase maturation factor; Region: LMF1; pfam06762 419947000690 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 419947000691 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 419947000692 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 419947000693 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 419947000694 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 419947000695 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 419947000696 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 419947000697 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 419947000698 MaoC like domain; Region: MaoC_dehydratas; pfam01575 419947000699 active site 2 [active] 419947000700 active site 1 [active] 419947000701 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 419947000702 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 419947000703 NAD(P) binding site [chemical binding]; other site 419947000704 active site 419947000705 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 419947000706 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 419947000707 dimer interface [polypeptide binding]; other site 419947000708 active site 419947000709 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 419947000710 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 419947000711 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 419947000712 FAD binding site [chemical binding]; other site 419947000713 substrate binding site [chemical binding]; other site 419947000714 catalytic residues [active] 419947000715 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 419947000716 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 419947000717 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 419947000718 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 419947000719 catalytic loop [active] 419947000720 iron binding site [ion binding]; other site 419947000721 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 419947000722 L-aspartate oxidase; Provisional; Region: PRK06175 419947000723 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 419947000724 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 419947000725 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 419947000726 putative dimer interface [polypeptide binding]; other site 419947000727 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 419947000728 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 419947000729 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 419947000730 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 419947000731 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 419947000732 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 419947000733 homotrimer interface [polypeptide binding]; other site 419947000734 Walker A motif; other site 419947000735 GTP binding site [chemical binding]; other site 419947000736 Walker B motif; other site 419947000737 cobyric acid synthase; Provisional; Region: PRK00784 419947000738 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 419947000739 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 419947000740 catalytic triad [active] 419947000741 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947000742 PPE family; Region: PPE; pfam00823 419947000743 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 419947000744 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 419947000745 putative active site [active] 419947000746 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 419947000747 putative active site [active] 419947000748 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 419947000749 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 419947000750 active site 419947000751 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 419947000752 DNA binding site [nucleotide binding] 419947000753 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 419947000754 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 419947000755 Coenzyme A binding pocket [chemical binding]; other site 419947000756 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 419947000757 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 419947000758 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 419947000759 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 419947000760 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 419947000761 intersubunit interface [polypeptide binding]; other site 419947000762 5-oxoprolinase; Region: PLN02666 419947000763 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 419947000764 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 419947000765 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 419947000766 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 419947000767 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 419947000768 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 419947000769 nucleotide binding site [chemical binding]; other site 419947000770 acyl-CoA synthetase; Validated; Region: PRK07788 419947000771 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 419947000772 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 419947000773 active site 419947000774 CoA binding site [chemical binding]; other site 419947000775 AMP binding site [chemical binding]; other site 419947000776 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 419947000777 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 419947000778 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 419947000779 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 419947000780 FAD binding site [chemical binding]; other site 419947000781 substrate binding site [chemical binding]; other site 419947000782 catalytic base [active] 419947000783 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 419947000784 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 419947000785 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 419947000786 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 419947000787 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 419947000788 Zn binding site [ion binding]; other site 419947000789 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 419947000790 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 419947000791 putative active site [active] 419947000792 PE family; Region: PE; pfam00934 419947000793 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947000794 PPE family; Region: PPE; pfam00823 419947000795 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947000796 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 419947000797 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 419947000798 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 419947000799 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 419947000800 Walker A motif; other site 419947000801 ATP binding site [chemical binding]; other site 419947000802 Walker B motif; other site 419947000803 arginine finger; other site 419947000804 Protein of unknown function (DUF690); Region: DUF690; pfam05108 419947000805 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 419947000806 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 419947000807 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 419947000808 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 419947000809 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 419947000810 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947000811 PPE family; Region: PPE; pfam00823 419947000812 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 419947000813 EspG family; Region: ESX-1_EspG; pfam14011 419947000814 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 419947000815 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 419947000816 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 419947000817 active site 419947000818 catalytic residues [active] 419947000819 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 419947000820 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 419947000821 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 419947000822 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 419947000823 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 419947000824 S-adenosylmethionine binding site [chemical binding]; other site 419947000825 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4424 419947000826 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 419947000827 Sulfatase; Region: Sulfatase; cl17466 419947000828 hypothetical protein; Region: PHA01748 419947000829 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 419947000830 putative active site [active] 419947000831 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 419947000832 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 419947000833 light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs; Region: LPOR_like_SDR_c_like; cd09810 419947000834 protochlorophyllide reductase; Region: PLN00015 419947000835 putative NAD(P) binding site [chemical binding]; other site 419947000836 active site 419947000837 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947000838 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 419947000839 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 419947000840 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947000841 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 419947000842 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 419947000843 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 419947000844 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947000845 PPE family; Region: PPE; pfam00823 419947000846 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 419947000847 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 419947000848 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 419947000849 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 419947000850 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947000851 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 419947000852 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 419947000853 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 419947000854 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 419947000855 putative FMN binding site [chemical binding]; other site 419947000856 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 419947000857 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 419947000858 active site 419947000859 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 419947000860 SnoaL-like domain; Region: SnoaL_4; pfam13577 419947000861 SnoaL-like domain; Region: SnoaL_3; pfam13474 419947000862 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 419947000863 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 419947000864 nucleotide binding site [chemical binding]; other site 419947000865 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]; Region: HtpG; COG0326 419947000866 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 419947000867 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 419947000868 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 419947000869 active site 419947000870 catalytic residues [active] 419947000871 Muconolactone delta-isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CatC1; COG4829 419947000872 Muconolactone delta-isomerase; Region: MIase; cl01992 419947000873 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 419947000874 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 419947000875 putative active site [active] 419947000876 catalytic site [active] 419947000877 putative metal binding site [ion binding]; other site 419947000878 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 419947000879 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 419947000880 putative substrate binding pocket [chemical binding]; other site 419947000881 AC domain interface; other site 419947000882 catalytic triad [active] 419947000883 AB domain interface; other site 419947000884 interchain disulfide; other site 419947000885 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 419947000886 trimer interface [polypeptide binding]; other site 419947000887 active site 419947000888 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 419947000889 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 419947000890 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 419947000891 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 419947000892 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 419947000893 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 419947000894 dimerization interface [polypeptide binding]; other site 419947000895 putative DNA binding site [nucleotide binding]; other site 419947000896 putative Zn2+ binding site [ion binding]; other site 419947000897 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 419947000898 active site residue [active] 419947000899 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 419947000900 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 419947000901 Cytochrome P450; Region: p450; cl12078 419947000902 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 419947000903 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 419947000904 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 419947000905 Methyltransferase domain; Region: Methyltransf_23; pfam13489 419947000906 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 419947000907 S-adenosylmethionine binding site [chemical binding]; other site 419947000908 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 419947000909 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 419947000910 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 419947000911 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 419947000912 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 419947000913 SnoaL-like domain; Region: SnoaL_2; pfam12680 419947000914 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 419947000915 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 419947000916 substrate binding site; other site 419947000917 tetramer interface; other site 419947000918 PE family; Region: PE; pfam00934 419947000919 Domain of unknown function (DUF222); Region: DUF222; pfam02720 419947000920 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 419947000921 active site 419947000922 aminotransferase AlaT; Validated; Region: PRK09265 419947000923 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 419947000924 pyridoxal 5'-phosphate binding site [chemical binding]; other site 419947000925 homodimer interface [polypeptide binding]; other site 419947000926 catalytic residue [active] 419947000927 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 419947000928 4Fe-4S binding domain; Region: Fer4; pfam00037 419947000929 Cysteine-rich domain; Region: CCG; pfam02754 419947000930 Cysteine-rich domain; Region: CCG; pfam02754 419947000931 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 419947000932 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 419947000933 DNA binding residues [nucleotide binding] 419947000934 dimerization interface [polypeptide binding]; other site 419947000935 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 419947000936 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 419947000937 G1 box; other site 419947000938 GTP/Mg2+ binding site [chemical binding]; other site 419947000939 G2 box; other site 419947000940 Switch I region; other site 419947000941 G3 box; other site 419947000942 Switch II region; other site 419947000943 G4 box; other site 419947000944 G5 box; other site 419947000945 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 419947000946 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 419947000947 G1 box; other site 419947000948 GTP/Mg2+ binding site [chemical binding]; other site 419947000949 G2 box; other site 419947000950 Switch I region; other site 419947000951 G3 box; other site 419947000952 Switch II region; other site 419947000953 Uncharacterized MobA-related protein [General function prediction only]; Region: COG2068 419947000954 active site 419947000955 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 419947000956 TIGR04255 family protein; Region: sporadTIGR04255 419947000957 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 419947000958 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 419947000959 nucleotide binding site [chemical binding]; other site 419947000960 NEF interaction site [polypeptide binding]; other site 419947000961 SBD interface [polypeptide binding]; other site 419947000962 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 419947000963 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 419947000964 dimer interface [polypeptide binding]; other site 419947000965 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 419947000966 chaperone protein DnaJ; Provisional; Region: PRK14279 419947000967 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 419947000968 HSP70 interaction site [polypeptide binding]; other site 419947000969 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 419947000970 Zn binding sites [ion binding]; other site 419947000971 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 419947000972 dimer interface [polypeptide binding]; other site 419947000973 Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279 419947000974 DNA binding residues [nucleotide binding] 419947000975 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 419947000976 putative dimer interface [polypeptide binding]; other site 419947000977 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947000978 PPE family; Region: PPE; pfam00823 419947000979 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 419947000980 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947000981 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947000982 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947000983 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 419947000984 CoenzymeA binding site [chemical binding]; other site 419947000985 subunit interaction site [polypeptide binding]; other site 419947000986 PHB binding site; other site 419947000987 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 419947000988 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 419947000989 GDP-binding site [chemical binding]; other site 419947000990 ACT binding site; other site 419947000991 IMP binding site; other site 419947000992 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 419947000993 Peptidase family M50; Region: Peptidase_M50; pfam02163 419947000994 active site 419947000995 putative substrate binding region [chemical binding]; other site 419947000996 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 419947000997 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 419947000998 MgtE intracellular N domain; Region: MgtE_N; pfam03448 419947000999 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 419947001000 Divalent cation transporter; Region: MgtE; pfam01769 419947001001 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 419947001002 fructose-bisphosphate aldolase, class II, yeast/E. coli subtype; Region: FruBisAldo_II_A; TIGR01520 419947001003 active site 419947001004 intersubunit interface [polypeptide binding]; other site 419947001005 zinc binding site [ion binding]; other site 419947001006 Na+ binding site [ion binding]; other site 419947001007 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 419947001008 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 419947001009 Predicted glycosyl hydrolase [Carbohydrate transport and metabolism]; Region: COG4833 419947001010 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 419947001011 AAA domain; Region: AAA_33; pfam13671 419947001012 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 419947001013 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 419947001014 putative hydrophobic ligand binding site [chemical binding]; other site 419947001015 MoxR-like ATPases [General function prediction only]; Region: COG0714 419947001016 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 419947001017 Ligand binding site; other site 419947001018 metal-binding site 419947001019 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 419947001020 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 419947001021 XdhC Rossmann domain; Region: XdhC_C; pfam13478 419947001022 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 419947001023 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 419947001024 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 419947001025 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 419947001026 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 419947001027 catalytic loop [active] 419947001028 iron binding site [ion binding]; other site 419947001029 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 419947001030 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 419947001031 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 419947001032 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 419947001033 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 419947001034 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 419947001035 XdhC Rossmann domain; Region: XdhC_C; pfam13478 419947001036 Transcriptional regulator [Transcription]; Region: LysR; COG0583 419947001037 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 419947001038 LysR substrate binding domain; Region: LysR_substrate; pfam03466 419947001039 dimerization interface [polypeptide binding]; other site 419947001040 Uncharacterized conserved protein [Function unknown]; Region: COG3360 419947001041 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 419947001042 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 419947001043 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 419947001044 active site 419947001045 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 419947001046 Clp amino terminal domain; Region: Clp_N; pfam02861 419947001047 Clp amino terminal domain; Region: Clp_N; pfam02861 419947001048 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 419947001049 Walker A motif; other site 419947001050 ATP binding site [chemical binding]; other site 419947001051 Walker B motif; other site 419947001052 arginine finger; other site 419947001053 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 419947001054 Walker A motif; other site 419947001055 ATP binding site [chemical binding]; other site 419947001056 Walker B motif; other site 419947001057 arginine finger; other site 419947001058 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 419947001059 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 419947001060 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 419947001061 heme-binding site [chemical binding]; other site 419947001062 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 419947001063 FAD binding pocket [chemical binding]; other site 419947001064 FAD binding motif [chemical binding]; other site 419947001065 phosphate binding motif [ion binding]; other site 419947001066 beta-alpha-beta structure motif; other site 419947001067 NAD binding pocket [chemical binding]; other site 419947001068 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 419947001069 cyclase homology domain; Region: CHD; cd07302 419947001070 nucleotidyl binding site; other site 419947001071 metal binding site [ion binding]; metal-binding site 419947001072 dimer interface [polypeptide binding]; other site 419947001073 Predicted ATPase [General function prediction only]; Region: COG3903 419947001074 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 419947001075 Walker A motif; other site 419947001076 ATP binding site [chemical binding]; other site 419947001077 Walker B motif; other site 419947001078 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 419947001079 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 419947001080 DNA binding residues [nucleotide binding] 419947001081 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947001082 PPE family; Region: PPE; pfam00823 419947001083 Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase) [Nucleotide transport and metabolism]; Region: PurT; COG0027 419947001084 ATP-grasp domain; Region: ATP-grasp_4; cl17255 419947001085 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 419947001086 active site residue [active] 419947001087 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 419947001088 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 419947001089 homodimer interface [polypeptide binding]; other site 419947001090 substrate-cofactor binding pocket; other site 419947001091 pyridoxal 5'-phosphate binding site [chemical binding]; other site 419947001092 catalytic residue [active] 419947001093 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 419947001094 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 419947001095 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 419947001096 Domain of unknown function (DUF222); Region: DUF222; pfam02720 419947001097 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 419947001098 active site 419947001099 PLD-like domain; Region: PLDc_2; pfam13091 419947001100 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 419947001101 Beta-lactamase; Region: Beta-lactamase; pfam00144 419947001102 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 419947001103 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 419947001104 FAD binding site [chemical binding]; other site 419947001105 substrate binding pocket [chemical binding]; other site 419947001106 catalytic base [active] 419947001107 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 419947001108 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 419947001109 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 419947001110 acyl-CoA synthetase; Validated; Region: PRK05850 419947001111 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 419947001112 acyl-activating enzyme (AAE) consensus motif; other site 419947001113 active site 419947001114 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 419947001115 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 419947001116 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 419947001117 active site 419947001118 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 419947001119 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 419947001120 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 419947001121 Thioesterase; Region: PKS_TE; smart00824 419947001122 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 419947001123 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 419947001124 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 419947001125 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 419947001126 phosphate acetyltransferase; Reviewed; Region: PRK05632 419947001127 DRTGG domain; Region: DRTGG; pfam07085 419947001128 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 419947001129 propionate/acetate kinase; Provisional; Region: PRK12379 419947001130 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 419947001131 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 419947001132 Catalytic domain of Protein Kinases; Region: PKc; cd00180 419947001133 active site 419947001134 ATP binding site [chemical binding]; other site 419947001135 substrate binding site [chemical binding]; other site 419947001136 activation loop (A-loop); other site 419947001137 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 419947001138 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 419947001139 substrate binding pocket [chemical binding]; other site 419947001140 membrane-bound complex binding site; other site 419947001141 hinge residues; other site 419947001142 NUDIX domain; Region: NUDIX; pfam00293 419947001143 nudix motif; other site 419947001144 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 419947001145 thiamine phosphate binding site [chemical binding]; other site 419947001146 active site 419947001147 pyrophosphate binding site [ion binding]; other site 419947001148 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 419947001149 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 419947001150 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 419947001151 thiS-thiF/thiG interaction site; other site 419947001152 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 419947001153 ThiS interaction site; other site 419947001154 putative active site [active] 419947001155 tetramer interface [polypeptide binding]; other site 419947001156 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 419947001157 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 419947001158 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 419947001159 PA/protease or protease-like domain interface [polypeptide binding]; other site 419947001160 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 419947001161 active site 419947001162 metal binding site [ion binding]; metal-binding site 419947001163 Predicted metalloprotease [General function prediction only]; Region: COG2321 419947001164 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 419947001165 Zn binding site [ion binding]; other site 419947001166 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 419947001167 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 419947001168 dimer interface [polypeptide binding]; other site 419947001169 substrate binding site [chemical binding]; other site 419947001170 ATP binding site [chemical binding]; other site 419947001171 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 419947001172 ThiC-associated domain; Region: ThiC-associated; pfam13667 419947001173 ThiC family; Region: ThiC; pfam01964 419947001174 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 419947001175 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 419947001176 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 419947001177 motif II; other site 419947001178 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 419947001179 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 419947001180 putative catalytic site [active] 419947001181 putative phosphate binding site [ion binding]; other site 419947001182 active site 419947001183 metal binding site A [ion binding]; metal-binding site 419947001184 DNA binding site [nucleotide binding] 419947001185 putative AP binding site [nucleotide binding]; other site 419947001186 putative metal binding site B [ion binding]; other site 419947001187 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 419947001188 active site 419947001189 catalytic residues [active] 419947001190 metal binding site [ion binding]; metal-binding site 419947001191 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 419947001192 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 419947001193 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 419947001194 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 419947001195 E-class dimer interface [polypeptide binding]; other site 419947001196 P-class dimer interface [polypeptide binding]; other site 419947001197 active site 419947001198 Cu2+ binding site [ion binding]; other site 419947001199 Zn2+ binding site [ion binding]; other site 419947001200 carboxylate-amine ligase; Provisional; Region: PRK13517 419947001201 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 419947001202 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 419947001203 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 419947001204 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 419947001205 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 419947001206 Walker A motif; other site 419947001207 ATP binding site [chemical binding]; other site 419947001208 Walker B motif; other site 419947001209 arginine finger; other site 419947001210 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 419947001211 Walker A motif; other site 419947001212 ATP binding site [chemical binding]; other site 419947001213 Walker B motif; other site 419947001214 arginine finger; other site 419947001215 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 419947001216 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 419947001217 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 419947001218 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 419947001219 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 419947001220 dimer interface [polypeptide binding]; other site 419947001221 putative functional site; other site 419947001222 putative MPT binding site; other site 419947001223 short chain dehydrogenase; Provisional; Region: PRK06197 419947001224 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 419947001225 putative NAD(P) binding site [chemical binding]; other site 419947001226 active site 419947001227 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 419947001228 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 419947001229 ring oligomerisation interface [polypeptide binding]; other site 419947001230 ATP/Mg binding site [chemical binding]; other site 419947001231 stacking interactions; other site 419947001232 hinge regions; other site 419947001233 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947001234 PPE family; Region: PPE; pfam00823 419947001235 Protein of unknown function (DUF664); Region: DUF664; pfam04978 419947001236 DinB superfamily; Region: DinB_2; pfam12867 419947001237 putative anti-sigmaE protein; Provisional; Region: PRK13920 419947001238 Anti-sigma-K factor rskA; Region: RskA; pfam10099 419947001239 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 419947001240 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 419947001241 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 419947001242 DNA binding residues [nucleotide binding] 419947001243 Steroid 5-alpha reductase family enzyme [General function prediction only]; Region: COG3752 419947001244 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 419947001245 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 419947001246 S-adenosylmethionine binding site [chemical binding]; other site 419947001247 Uncharacterized conserved protein [Function unknown]; Region: COG3496 419947001248 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 419947001249 Subunit A of Class III extradiol dioxygenases; Region: Extradiol_Dioxygenase_3A_like; cl06673 419947001250 dimer interface [polypeptide binding]; other site 419947001251 Transport protein; Region: actII; TIGR00833 419947001252 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 419947001253 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 419947001254 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947001255 PPE family; Region: PPE; pfam00823 419947001256 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947001257 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 419947001258 enoyl-CoA hydratase; Provisional; Region: PRK12478 419947001259 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 419947001260 substrate binding site [chemical binding]; other site 419947001261 oxyanion hole (OAH) forming residues; other site 419947001262 trimer interface [polypeptide binding]; other site 419947001263 PemK-like protein; Region: PemK; pfam02452 419947001264 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 419947001265 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 419947001266 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 419947001267 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 419947001268 NAD(P) binding site [chemical binding]; other site 419947001269 catalytic residues [active] 419947001270 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3564 419947001271 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 419947001272 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 419947001273 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 419947001274 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 419947001275 Uncharacterized conserved protein [Function unknown]; Region: COG2128 419947001276 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 419947001277 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 419947001278 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 419947001279 non-specific DNA binding site [nucleotide binding]; other site 419947001280 salt bridge; other site 419947001281 sequence-specific DNA binding site [nucleotide binding]; other site 419947001282 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 419947001283 Domain of unknown function (DUF955); Region: DUF955; pfam06114 419947001284 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 419947001285 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 419947001286 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 419947001287 active site 419947001288 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 419947001289 active site 2 [active] 419947001290 isocitrate lyase; Provisional; Region: PRK15063 419947001291 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cd06556 419947001292 oligomerization interface [polypeptide binding]; other site 419947001293 active site 419947001294 metal binding site [ion binding]; metal-binding site 419947001295 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 419947001296 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 419947001297 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 419947001298 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 419947001299 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 419947001300 S-adenosylmethionine binding site [chemical binding]; other site 419947001301 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 419947001302 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 419947001303 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 419947001304 S-adenosylmethionine binding site [chemical binding]; other site 419947001305 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 419947001306 UbiA prenyltransferase family; Region: UbiA; pfam01040 419947001307 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 419947001308 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 419947001309 Predicted membrane protein [Function unknown]; Region: COG2733 419947001310 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 419947001311 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 419947001312 non-specific DNA binding site [nucleotide binding]; other site 419947001313 salt bridge; other site 419947001314 sequence-specific DNA binding site [nucleotide binding]; other site 419947001315 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 419947001316 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 419947001317 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 419947001318 intersubunit interface [polypeptide binding]; other site 419947001319 active site 419947001320 catalytic residue [active] 419947001321 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 419947001322 Predicted amidohydrolase [General function prediction only]; Region: COG0388 419947001323 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 419947001324 putative active site [active] 419947001325 catalytic triad [active] 419947001326 putative dimer interface [polypeptide binding]; other site 419947001327 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 419947001328 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 419947001329 FAD binding domain; Region: FAD_binding_4; pfam01565 419947001330 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 419947001331 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 419947001332 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 419947001333 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 419947001334 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 419947001335 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 419947001336 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 419947001337 NAD(P) binding site [chemical binding]; other site 419947001338 active site 419947001339 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 419947001340 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 419947001341 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 419947001342 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 419947001343 putative ADP-binding pocket [chemical binding]; other site 419947001344 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 419947001345 L-lysine exporter; Region: 2a75; TIGR00948 419947001346 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 419947001347 catalytic core [active] 419947001348 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 419947001349 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 419947001350 dimer interface [polypeptide binding]; other site 419947001351 phosphorylation site [posttranslational modification] 419947001352 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 419947001353 ATP binding site [chemical binding]; other site 419947001354 Mg2+ binding site [ion binding]; other site 419947001355 G-X-G motif; other site 419947001356 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 419947001357 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 419947001358 active site 419947001359 phosphorylation site [posttranslational modification] 419947001360 intermolecular recognition site; other site 419947001361 dimerization interface [polypeptide binding]; other site 419947001362 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 419947001363 DNA binding site [nucleotide binding] 419947001364 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 419947001365 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 419947001366 Transcriptional regulators [Transcription]; Region: FadR; COG2186 419947001367 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 419947001368 DNA-binding site [nucleotide binding]; DNA binding site 419947001369 FCD domain; Region: FCD; pfam07729 419947001370 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 419947001371 exopolyphosphatase; Region: exo_poly_only; TIGR03706 419947001372 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 419947001373 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 419947001374 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 419947001375 Diacylglycerol kinase catalytic domain (presumed); Region: DAGKc; smart00046 419947001376 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 419947001377 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 419947001378 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 419947001379 DNA binding domain, excisionase family; Region: excise; TIGR01764 419947001380 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 419947001381 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 419947001382 putative NAD(P) binding site [chemical binding]; other site 419947001383 active site 419947001384 putative substrate binding site [chemical binding]; other site 419947001385 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 419947001386 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 419947001387 putative acyl-acceptor binding pocket; other site 419947001388 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 419947001389 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 419947001390 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 419947001391 S-adenosylmethionine binding site [chemical binding]; other site 419947001392 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 419947001393 active site 419947001394 catalytic site [active] 419947001395 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 419947001396 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 419947001397 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 419947001398 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 419947001399 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 419947001400 glutamyl-tRNA reductase; Region: hemA; TIGR01035 419947001401 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 419947001402 tRNA; other site 419947001403 putative tRNA binding site [nucleotide binding]; other site 419947001404 putative NADP binding site [chemical binding]; other site 419947001405 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 419947001406 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 419947001407 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 419947001408 domain interfaces; other site 419947001409 active site 419947001410 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 419947001411 active site 419947001412 homodimer interface [polypeptide binding]; other site 419947001413 SAM binding site [chemical binding]; other site 419947001414 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 419947001415 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 419947001416 active site 419947001417 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 419947001418 dimer interface [polypeptide binding]; other site 419947001419 active site 419947001420 Schiff base residues; other site 419947001421 Domain of unknown function (DUF222); Region: DUF222; pfam02720 419947001422 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 419947001423 active site 419947001424 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 419947001425 anti sigma factor interaction site; other site 419947001426 regulatory phosphorylation site [posttranslational modification]; other site 419947001427 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 419947001428 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 419947001429 active site 419947001430 catalytic triad [active] 419947001431 oxyanion hole [active] 419947001432 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 419947001433 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 419947001434 Methyltransferase domain; Region: Methyltransf_31; pfam13847 419947001435 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 419947001436 Domain of unknown function (DUF385); Region: DUF385; pfam04075 419947001437 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 419947001438 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 419947001439 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 419947001440 catalytic residue [active] 419947001441 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 419947001442 catalytic core [active] 419947001443 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 419947001444 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 419947001445 catalytic residues [active] 419947001446 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 419947001447 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 419947001448 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 419947001449 ResB-like family; Region: ResB; pfam05140 419947001450 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 419947001451 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 419947001452 AAA domain; Region: AAA_31; pfam13614 419947001453 P-loop; other site 419947001454 Magnesium ion binding site [ion binding]; other site 419947001455 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 419947001456 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 419947001457 3-oxoacyl-(acyl-carrier-protein) synthase III; Region: fabH; TIGR00747 419947001458 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 419947001459 dimer interface [polypeptide binding]; other site 419947001460 active site 419947001461 CoA binding pocket [chemical binding]; other site 419947001462 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 419947001463 UbiA prenyltransferase family; Region: UbiA; pfam01040 419947001464 5'-methylthioadenosine phosphorylase; Validated; Region: PRK07823 419947001465 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 419947001466 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 419947001467 NAD(P) binding site [chemical binding]; other site 419947001468 active site 419947001469 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 419947001470 Ligand binding site; other site 419947001471 Putative Catalytic site; other site 419947001472 DXD motif; other site 419947001473 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3222 419947001474 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 419947001475 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 419947001476 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 419947001477 acyl-activating enzyme (AAE) consensus motif; other site 419947001478 acyl-activating enzyme (AAE) consensus motif; other site 419947001479 AMP binding site [chemical binding]; other site 419947001480 active site 419947001481 CoA binding site [chemical binding]; other site 419947001482 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 419947001483 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 419947001484 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 419947001485 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 419947001486 active site 419947001487 short chain dehydrogenase; Provisional; Region: PRK05866 419947001488 classical (c) SDRs; Region: SDR_c; cd05233 419947001489 NAD(P) binding site [chemical binding]; other site 419947001490 active site 419947001491 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 419947001492 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 419947001493 substrate binding site [chemical binding]; other site 419947001494 oxyanion hole (OAH) forming residues; other site 419947001495 trimer interface [polypeptide binding]; other site 419947001496 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 419947001497 putative active site [active] 419947001498 homotetrameric interface [polypeptide binding]; other site 419947001499 metal binding site [ion binding]; metal-binding site 419947001500 Post-segregation antitoxin (ccd killing mechanism protein) encoded by the F plasmid [General function prediction only]; Region: COG5302 419947001501 acyl-CoA synthetase; Validated; Region: PRK06188 419947001502 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 419947001503 putative active site [active] 419947001504 putative CoA binding site [chemical binding]; other site 419947001505 putative AMP binding site [chemical binding]; other site 419947001506 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 419947001507 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 419947001508 active site 419947001509 O-succinylbenzoate synthase; Provisional; Region: PRK02901 419947001510 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 419947001511 active site 419947001512 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 419947001513 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 419947001514 TAP-like protein; Region: Abhydrolase_4; pfam08386 419947001515 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 419947001516 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 419947001517 dimer interface [polypeptide binding]; other site 419947001518 tetramer interface [polypeptide binding]; other site 419947001519 PYR/PP interface [polypeptide binding]; other site 419947001520 TPP binding site [chemical binding]; other site 419947001521 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 419947001522 TPP-binding site; other site 419947001523 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 419947001524 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 419947001525 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 419947001526 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 419947001527 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 419947001528 S-adenosylmethionine binding site [chemical binding]; other site 419947001529 Protein of unknown function (DUF732); Region: DUF732; pfam05305 419947001530 Methyltransferase domain; Region: Methyltransf_23; pfam13489 419947001531 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 419947001532 S-adenosylmethionine binding site [chemical binding]; other site 419947001533 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 419947001534 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 419947001535 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 419947001536 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 419947001537 substrate binding pocket [chemical binding]; other site 419947001538 chain length determination region; other site 419947001539 substrate-Mg2+ binding site; other site 419947001540 catalytic residues [active] 419947001541 aspartate-rich region 1; other site 419947001542 active site lid residues [active] 419947001543 aspartate-rich region 2; other site 419947001544 heat shock protein HtpX; Provisional; Region: PRK03072 419947001545 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439 419947001546 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 419947001547 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 419947001548 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 419947001549 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 419947001550 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 419947001551 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 419947001552 O-methyltransferase; Region: Methyltransf_2; pfam00891 419947001553 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 419947001554 Cytochrome P450; Region: p450; cl12078 419947001555 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 419947001556 ATP cone domain; Region: ATP-cone; pfam03477 419947001557 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 419947001558 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 419947001559 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 419947001560 active site 419947001561 dimer interface [polypeptide binding]; other site 419947001562 effector binding site; other site 419947001563 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 419947001564 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 419947001565 active site 419947001566 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 419947001567 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 419947001568 nicotinate phosphoribosyltransferase; Provisional; Region: PRK12484 419947001569 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 419947001570 active site 419947001571 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 419947001572 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 419947001573 putative active site [active] 419947001574 putative metal binding site [ion binding]; other site 419947001575 hypothetical protein; Provisional; Region: PRK07588 419947001576 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 419947001577 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 419947001578 dimerization interface [polypeptide binding]; other site 419947001579 putative DNA binding site [nucleotide binding]; other site 419947001580 putative Zn2+ binding site [ion binding]; other site 419947001581 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 419947001582 putative hydrophobic ligand binding site [chemical binding]; other site 419947001583 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 419947001584 TIGR03086 family protein; Region: TIGR03086 419947001585 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 419947001586 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 419947001587 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 419947001588 PE family; Region: PE; pfam00934 419947001589 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451 419947001590 Uncharacterized conserved protein [Function unknown]; Region: COG1656 419947001591 Protein of unknown function DUF82; Region: DUF82; pfam01927 419947001592 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 419947001593 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 419947001594 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 419947001595 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 419947001596 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 419947001597 Transcriptional regulators [Transcription]; Region: FadR; COG2186 419947001598 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 419947001599 DNA-binding site [nucleotide binding]; DNA binding site 419947001600 FCD domain; Region: FCD; pfam07729 419947001601 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 419947001602 Permease; Region: Permease; pfam02405 419947001603 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 419947001604 Permease; Region: Permease; pfam02405 419947001605 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 419947001606 mce related protein; Region: MCE; pfam02470 419947001607 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 419947001608 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 419947001609 mce related protein; Region: MCE; pfam02470 419947001610 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 419947001611 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 419947001612 mce related protein; Region: MCE; pfam02470 419947001613 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 419947001614 mce related protein; Region: MCE; pfam02470 419947001615 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 419947001616 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 419947001617 mce related protein; Region: MCE; pfam02470 419947001618 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 419947001619 mce related protein; Region: MCE; pfam02470 419947001620 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 419947001621 oligomeric interface; other site 419947001622 putative active site [active] 419947001623 homodimer interface [polypeptide binding]; other site 419947001624 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 419947001625 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 419947001626 AAA domain; Region: AAA_14; pfam13173 419947001627 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 419947001628 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 419947001629 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 419947001630 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 419947001631 ATP binding site [chemical binding]; other site 419947001632 Mg2+ binding site [ion binding]; other site 419947001633 G-X-G motif; other site 419947001634 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 419947001635 dimerization interface [polypeptide binding]; other site 419947001636 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 419947001637 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 419947001638 active site 419947001639 phosphorylation site [posttranslational modification] 419947001640 intermolecular recognition site; other site 419947001641 dimerization interface [polypeptide binding]; other site 419947001642 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 419947001643 DNA binding site [nucleotide binding] 419947001644 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 419947001645 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 419947001646 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 419947001647 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 419947001648 catalytic residues [active] 419947001649 catalytic nucleophile [active] 419947001650 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 419947001651 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 419947001652 Probable transposase; Region: OrfB_IS605; pfam01385 419947001653 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 419947001654 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 419947001655 putative active site [active] 419947001656 SEC-C motif; Region: SEC-C; pfam02810 419947001657 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB-like; cd09875 419947001658 putative active site [active] 419947001659 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 419947001660 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 419947001661 nucleotide binding site/active site [active] 419947001662 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 419947001663 galactokinase; Provisional; Region: PRK00555 419947001664 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 419947001665 Protein of unknown function (DUF732); Region: DUF732; pfam05305 419947001666 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 419947001667 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 419947001668 putative active site [active] 419947001669 Uncharacterized conserved protein [Function unknown]; Region: COG0398 419947001670 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 419947001671 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 419947001672 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 419947001673 oligomeric interface; other site 419947001674 putative active site [active] 419947001675 homodimer interface [polypeptide binding]; other site 419947001676 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 419947001677 FIST N domain; Region: FIST; pfam08495 419947001678 FIST C domain; Region: FIST_C; pfam10442 419947001679 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 419947001680 AAA domain; Region: AAA_30; pfam13604 419947001681 Family description; Region: UvrD_C_2; pfam13538 419947001682 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 419947001683 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 419947001684 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 419947001685 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 419947001686 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 419947001687 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 419947001688 substrate binding site [chemical binding]; other site 419947001689 oxyanion hole (OAH) forming residues; other site 419947001690 trimer interface [polypeptide binding]; other site 419947001691 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 419947001692 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 419947001693 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 419947001694 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 419947001695 active site 419947001696 catalytic site [active] 419947001697 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 419947001698 active site 419947001699 catalytic site [active] 419947001700 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 419947001701 catalytic site [active] 419947001702 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 419947001703 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 419947001704 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 419947001705 putative homodimer interface [polypeptide binding]; other site 419947001706 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 419947001707 heterodimer interface [polypeptide binding]; other site 419947001708 homodimer interface [polypeptide binding]; other site 419947001709 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 419947001710 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 419947001711 23S rRNA interface [nucleotide binding]; other site 419947001712 L7/L12 interface [polypeptide binding]; other site 419947001713 putative thiostrepton binding site; other site 419947001714 L25 interface [polypeptide binding]; other site 419947001715 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 419947001716 mRNA/rRNA interface [nucleotide binding]; other site 419947001717 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 419947001718 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 419947001719 S-adenosylmethionine binding site [chemical binding]; other site 419947001720 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 419947001721 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 419947001722 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 419947001723 S-adenosylmethionine binding site [chemical binding]; other site 419947001724 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 419947001725 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 419947001726 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 419947001727 S-adenosylmethionine binding site [chemical binding]; other site 419947001728 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 419947001729 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 419947001730 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 419947001731 S-adenosylmethionine binding site [chemical binding]; other site 419947001732 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 419947001733 TAP-like protein; Region: Abhydrolase_4; pfam08386 419947001734 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 419947001735 ABC1 family; Region: ABC1; cl17513 419947001736 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 419947001737 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 419947001738 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 419947001739 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 419947001740 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 419947001741 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 419947001742 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 419947001743 23S rRNA interface [nucleotide binding]; other site 419947001744 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 419947001745 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 419947001746 core dimer interface [polypeptide binding]; other site 419947001747 peripheral dimer interface [polypeptide binding]; other site 419947001748 L10 interface [polypeptide binding]; other site 419947001749 L11 interface [polypeptide binding]; other site 419947001750 putative EF-Tu interaction site [polypeptide binding]; other site 419947001751 putative EF-G interaction site [polypeptide binding]; other site 419947001752 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 419947001753 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 419947001754 WHG domain; Region: WHG; pfam13305 419947001755 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 419947001756 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 419947001757 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 419947001758 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 419947001759 Walker A/P-loop; other site 419947001760 ATP binding site [chemical binding]; other site 419947001761 Q-loop/lid; other site 419947001762 ABC transporter signature motif; other site 419947001763 Walker B; other site 419947001764 D-loop; other site 419947001765 H-loop/switch region; other site 419947001766 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 419947001767 putative active site [active] 419947001768 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 419947001769 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 419947001770 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 419947001771 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG1848 419947001772 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 419947001773 Sulfatase; Region: Sulfatase; pfam00884 419947001774 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 419947001775 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 419947001776 putative active site [active] 419947001777 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 419947001778 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 419947001779 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 419947001780 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 419947001781 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 419947001782 RPB10 interaction site [polypeptide binding]; other site 419947001783 RPB1 interaction site [polypeptide binding]; other site 419947001784 RPB11 interaction site [polypeptide binding]; other site 419947001785 RPB3 interaction site [polypeptide binding]; other site 419947001786 RPB12 interaction site [polypeptide binding]; other site 419947001787 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 419947001788 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 419947001789 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 419947001790 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 419947001791 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 419947001792 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 419947001793 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 419947001794 G-loop; other site 419947001795 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 419947001796 DNA binding site [nucleotide binding] 419947001797 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 419947001798 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; pfam04734 419947001799 endonuclease IV; Provisional; Region: PRK01060 419947001800 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 419947001801 AP (apurinic/apyrimidinic) site pocket; other site 419947001802 DNA interaction; other site 419947001803 Metal-binding active site; metal-binding site 419947001804 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 419947001805 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 419947001806 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 419947001807 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 419947001808 active site 419947001809 enoyl-CoA hydratase; Provisional; Region: PRK12478 419947001810 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 419947001811 substrate binding site [chemical binding]; other site 419947001812 oxyanion hole (OAH) forming residues; other site 419947001813 trimer interface [polypeptide binding]; other site 419947001814 Phenylacetic acid-responsive transcriptional repressor [Transcription]; Region: PaaX; COG3327 419947001815 PaaX-like protein; Region: PaaX; pfam07848 419947001816 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 419947001817 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 419947001818 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 419947001819 substrate binding site [chemical binding]; other site 419947001820 oxyanion hole (OAH) forming residues; other site 419947001821 trimer interface [polypeptide binding]; other site 419947001822 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 419947001823 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 419947001824 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 419947001825 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 419947001826 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 419947001827 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 419947001828 WHG domain; Region: WHG; pfam13305 419947001829 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 419947001830 S17 interaction site [polypeptide binding]; other site 419947001831 S8 interaction site; other site 419947001832 16S rRNA interaction site [nucleotide binding]; other site 419947001833 streptomycin interaction site [chemical binding]; other site 419947001834 23S rRNA interaction site [nucleotide binding]; other site 419947001835 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 419947001836 30S ribosomal protein S7; Validated; Region: PRK05302 419947001837 elongation factor G; Reviewed; Region: PRK00007 419947001838 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 419947001839 G1 box; other site 419947001840 putative GEF interaction site [polypeptide binding]; other site 419947001841 GTP/Mg2+ binding site [chemical binding]; other site 419947001842 Switch I region; other site 419947001843 G2 box; other site 419947001844 G3 box; other site 419947001845 Switch II region; other site 419947001846 G4 box; other site 419947001847 G5 box; other site 419947001848 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 419947001849 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 419947001850 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 419947001851 elongation factor Tu; Reviewed; Region: PRK00049 419947001852 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 419947001853 G1 box; other site 419947001854 GEF interaction site [polypeptide binding]; other site 419947001855 GTP/Mg2+ binding site [chemical binding]; other site 419947001856 Switch I region; other site 419947001857 G2 box; other site 419947001858 G3 box; other site 419947001859 Switch II region; other site 419947001860 G4 box; other site 419947001861 G5 box; other site 419947001862 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 419947001863 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 419947001864 Antibiotic Binding Site [chemical binding]; other site 419947001865 Short C-terminal domain; Region: SHOCT; pfam09851 419947001866 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 419947001867 classical (c) SDRs; Region: SDR_c; cd05233 419947001868 NAD(P) binding site [chemical binding]; other site 419947001869 active site 419947001870 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 419947001871 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 419947001872 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4427 419947001873 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 419947001874 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 419947001875 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 419947001876 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 419947001877 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 419947001878 FeS/SAM binding site; other site 419947001879 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 419947001880 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 419947001881 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 419947001882 phosphate binding site [ion binding]; other site 419947001883 mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964 419947001884 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 419947001885 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 419947001886 Probable Catalytic site; other site 419947001887 metal-binding site 419947001888 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 419947001889 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 419947001890 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 419947001891 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 419947001892 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 419947001893 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 419947001894 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 419947001895 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 419947001896 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 419947001897 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 419947001898 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 419947001899 putative translocon binding site; other site 419947001900 protein-rRNA interface [nucleotide binding]; other site 419947001901 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 419947001902 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 419947001903 G-X-X-G motif; other site 419947001904 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 419947001905 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 419947001906 23S rRNA interface [nucleotide binding]; other site 419947001907 5S rRNA interface [nucleotide binding]; other site 419947001908 putative antibiotic binding site [chemical binding]; other site 419947001909 L25 interface [polypeptide binding]; other site 419947001910 L27 interface [polypeptide binding]; other site 419947001911 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 419947001912 putative translocon interaction site; other site 419947001913 23S rRNA interface [nucleotide binding]; other site 419947001914 signal recognition particle (SRP54) interaction site; other site 419947001915 L23 interface [polypeptide binding]; other site 419947001916 trigger factor interaction site; other site 419947001917 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 419947001918 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 419947001919 Sulfatase; Region: Sulfatase; pfam00884 419947001920 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353 419947001921 Uncharacterized conserved protein [Function unknown]; Region: COG1262 419947001922 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 419947001923 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 419947001924 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 419947001925 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 419947001926 RNA binding site [nucleotide binding]; other site 419947001927 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 419947001928 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 419947001929 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 419947001930 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 419947001931 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 419947001932 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 419947001933 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 419947001934 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 419947001935 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 419947001936 5S rRNA interface [nucleotide binding]; other site 419947001937 23S rRNA interface [nucleotide binding]; other site 419947001938 L5 interface [polypeptide binding]; other site 419947001939 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 419947001940 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 419947001941 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 419947001942 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 419947001943 23S rRNA binding site [nucleotide binding]; other site 419947001944 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 419947001945 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 419947001946 tandem repeat interface [polypeptide binding]; other site 419947001947 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 419947001948 oligomer interface [polypeptide binding]; other site 419947001949 active site residues [active] 419947001950 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 419947001951 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 419947001952 tandem repeat interface [polypeptide binding]; other site 419947001953 oligomer interface [polypeptide binding]; other site 419947001954 active site residues [active] 419947001955 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 419947001956 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 419947001957 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 419947001958 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 419947001959 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 419947001960 intersubunit interface [polypeptide binding]; other site 419947001961 active site 419947001962 Zn2+ binding site [ion binding]; other site 419947001963 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 419947001964 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 419947001965 NAD binding site [chemical binding]; other site 419947001966 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 419947001967 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 419947001968 nucleotide binding site [chemical binding]; other site 419947001969 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 419947001970 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 419947001971 Coenzyme A binding pocket [chemical binding]; other site 419947001972 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 419947001973 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 419947001974 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 419947001975 SecY translocase; Region: SecY; pfam00344 419947001976 adenylate kinase; Reviewed; Region: adk; PRK00279 419947001977 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 419947001978 AMP-binding site [chemical binding]; other site 419947001979 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 419947001980 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 419947001981 active site 419947001982 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 419947001983 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 419947001984 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 419947001985 DNA binding residues [nucleotide binding] 419947001986 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 419947001987 Putative zinc-finger; Region: zf-HC2; pfam13490 419947001988 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 419947001989 PYR/PP interface [polypeptide binding]; other site 419947001990 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 419947001991 MarR family; Region: MarR; pfam01047 419947001992 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 419947001993 TIGR03086 family protein; Region: TIGR03086 419947001994 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 419947001995 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 419947001996 Transposase; Region: DDE_Tnp_ISL3; pfam01610 419947001997 Helix-turn-helix domain; Region: HTH_17; pfam12728 419947001998 PE family; Region: PE; pfam00934 419947001999 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 419947002000 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 419947002001 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 419947002002 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 419947002003 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 419947002004 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 419947002005 active site 419947002006 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 419947002007 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 419947002008 tetrameric interface [polypeptide binding]; other site 419947002009 NAD binding site [chemical binding]; other site 419947002010 catalytic residues [active] 419947002011 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 419947002012 catalytic core [active] 419947002013 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947002014 PPE family; Region: PPE; pfam00823 419947002015 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 419947002016 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 419947002017 Helix-turn-helix domain; Region: HTH_28; pfam13518 419947002018 Winged helix-turn helix; Region: HTH_29; pfam13551 419947002019 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 419947002020 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 419947002021 active site 419947002022 phosphorylation site [posttranslational modification] 419947002023 intermolecular recognition site; other site 419947002024 dimerization interface [polypeptide binding]; other site 419947002025 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 419947002026 DNA binding site [nucleotide binding] 419947002027 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 419947002028 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 419947002029 dimerization interface [polypeptide binding]; other site 419947002030 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 419947002031 dimer interface [polypeptide binding]; other site 419947002032 phosphorylation site [posttranslational modification] 419947002033 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 419947002034 ATP binding site [chemical binding]; other site 419947002035 Mg2+ binding site [ion binding]; other site 419947002036 G-X-G motif; other site 419947002037 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 419947002038 nucleotide binding site/active site [active] 419947002039 HIT family signature motif; other site 419947002040 catalytic residue [active] 419947002041 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 419947002042 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 419947002043 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 419947002044 NAD binding site [chemical binding]; other site 419947002045 catalytic Zn binding site [ion binding]; other site 419947002046 substrate binding site [chemical binding]; other site 419947002047 structural Zn binding site [ion binding]; other site 419947002048 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 419947002049 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 419947002050 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 419947002051 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 419947002052 Cytochrome P450; Region: p450; cl12078 419947002053 short chain dehydrogenase; Provisional; Region: PRK07775 419947002054 classical (c) SDRs; Region: SDR_c; cd05233 419947002055 NAD(P) binding site [chemical binding]; other site 419947002056 active site 419947002057 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 419947002058 Cytochrome P450; Region: p450; cl12078 419947002059 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 419947002060 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 419947002061 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 419947002062 NAD binding site [chemical binding]; other site 419947002063 catalytic residues [active] 419947002064 short chain dehydrogenase; Provisional; Region: PRK07774 419947002065 classical (c) SDRs; Region: SDR_c; cd05233 419947002066 NAD(P) binding site [chemical binding]; other site 419947002067 active site 419947002068 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 419947002069 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 419947002070 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 419947002071 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 419947002072 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 419947002073 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 419947002074 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 419947002075 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 419947002076 Predicted esterase [General function prediction only]; Region: COG0627 419947002077 S-formylglutathione hydrolase; Region: PLN02442 419947002078 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 419947002079 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 419947002080 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 419947002081 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 419947002082 tetramer interface [polypeptide binding]; other site 419947002083 active site 419947002084 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 419947002085 Cytochrome P450; Region: p450; cl12078 419947002086 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 419947002087 ATP binding site [chemical binding]; other site 419947002088 active site 419947002089 substrate binding site [chemical binding]; other site 419947002090 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 419947002091 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 419947002092 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 419947002093 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 419947002094 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 419947002095 putative substrate translocation pore; other site 419947002096 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 419947002097 Predicted deacetylase [General function prediction only]; Region: COG3233 419947002098 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 419947002099 putative active site [active] 419947002100 putative Zn binding site [ion binding]; other site 419947002101 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 419947002102 FAD binding domain; Region: FAD_binding_2; pfam00890 419947002103 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 419947002104 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 419947002105 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 419947002106 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 419947002107 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 419947002108 putative active site [active] 419947002109 catalytic triad [active] 419947002110 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 419947002111 Transglutaminase/protease-like homologues; Region: TGc; smart00460 419947002112 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 419947002113 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 419947002114 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 419947002115 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 419947002116 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 419947002117 DNA-binding site [nucleotide binding]; DNA binding site 419947002118 UTRA domain; Region: UTRA; pfam07702 419947002119 Uncharacterized conserved protein [Function unknown]; Region: COG1359 419947002120 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 419947002121 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 419947002122 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 419947002123 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 419947002124 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 419947002125 Transposase; Region: HTH_Tnp_1; cl17663 419947002126 putative transposase OrfB; Reviewed; Region: PHA02517 419947002127 HTH-like domain; Region: HTH_21; pfam13276 419947002128 Integrase core domain; Region: rve; pfam00665 419947002129 Integrase core domain; Region: rve_3; pfam13683 419947002130 Transposase; Region: DEDD_Tnp_IS110; pfam01548 419947002131 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 419947002132 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 419947002133 Uncharacterized protein, linocin/CFP29 homolog [Function unknown]; Region: COG1659 419947002134 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 419947002135 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 419947002136 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 419947002137 active site 419947002138 metal binding site [ion binding]; metal-binding site 419947002139 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 419947002140 active site 419947002141 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 419947002142 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 419947002143 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 419947002144 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 419947002145 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 419947002146 dimerization interface [polypeptide binding]; other site 419947002147 ATP binding site [chemical binding]; other site 419947002148 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 419947002149 dimerization interface [polypeptide binding]; other site 419947002150 ATP binding site [chemical binding]; other site 419947002151 CAAX protease self-immunity; Region: Abi; pfam02517 419947002152 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 419947002153 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 419947002154 active site 419947002155 metal binding site [ion binding]; metal-binding site 419947002156 hexamer interface [polypeptide binding]; other site 419947002157 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 419947002158 amidophosphoribosyltransferase; Provisional; Region: PRK07847 419947002159 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 419947002160 active site 419947002161 tetramer interface [polypeptide binding]; other site 419947002162 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 419947002163 active site 419947002164 phosphoribosylaminoimidazole synthetase; Region: purM; TIGR00878 419947002165 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 419947002166 dimerization interface [polypeptide binding]; other site 419947002167 putative ATP binding site [chemical binding]; other site 419947002168 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 419947002169 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 419947002170 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 419947002171 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 419947002172 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 419947002173 pyridoxal 5'-phosphate binding site [chemical binding]; other site 419947002174 catalytic residue [active] 419947002175 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 419947002176 heme-binding site [chemical binding]; other site 419947002177 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 419947002178 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 419947002179 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 419947002180 active site residue [active] 419947002181 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 419947002182 active site residue [active] 419947002183 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 419947002184 catalytic residues [active] 419947002185 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 419947002186 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 419947002187 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 419947002188 DNA binding site [nucleotide binding] 419947002189 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 419947002190 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 419947002191 Coenzyme A binding pocket [chemical binding]; other site 419947002192 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 419947002193 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 419947002194 Walker A/P-loop; other site 419947002195 ATP binding site [chemical binding]; other site 419947002196 Q-loop/lid; other site 419947002197 ABC transporter signature motif; other site 419947002198 Walker B; other site 419947002199 D-loop; other site 419947002200 H-loop/switch region; other site 419947002201 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 419947002202 PhoU domain; Region: PhoU; pfam01895 419947002203 PhoU domain; Region: PhoU; pfam01895 419947002204 cell envelope-related function transcriptional attenuator common domain; Region: lytR_cpsA_psr; TIGR00350 419947002205 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 419947002206 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 419947002207 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 419947002208 FMN binding site [chemical binding]; other site 419947002209 active site 419947002210 catalytic residues [active] 419947002211 substrate binding site [chemical binding]; other site 419947002212 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 419947002213 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 419947002214 homodimer interface [polypeptide binding]; other site 419947002215 putative substrate binding pocket [chemical binding]; other site 419947002216 diiron center [ion binding]; other site 419947002217 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 419947002218 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 419947002219 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 419947002220 dimerization interface [polypeptide binding]; other site 419947002221 putative DNA binding site [nucleotide binding]; other site 419947002222 putative Zn2+ binding site [ion binding]; other site 419947002223 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 419947002224 dimer interface [polypeptide binding]; other site 419947002225 catalytic motif [active] 419947002226 nucleoside/Zn binding site; other site 419947002227 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 419947002228 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 419947002229 TIGR04255 family protein; Region: sporadTIGR04255 419947002230 PE family; Region: PE; pfam00934 419947002231 PE family; Region: PE; pfam00934 419947002232 PknH-like extracellular domain; Region: PknH_C; pfam14032 419947002233 Predicted nucleotidyltransferase [General function prediction only]; Region: COG4849 419947002234 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4861 419947002235 Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952 419947002236 D-ala-D-ala dipeptidase; Region: Peptidase_M15; pfam01427 419947002237 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 419947002238 S-adenosylmethionine binding site [chemical binding]; other site 419947002239 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 419947002240 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 419947002241 putative substrate translocation pore; other site 419947002242 Major Facilitator Superfamily; Region: MFS_1; pfam07690 419947002243 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 419947002244 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 419947002245 tetramer interface [polypeptide binding]; other site 419947002246 TPP-binding site [chemical binding]; other site 419947002247 heterodimer interface [polypeptide binding]; other site 419947002248 phosphorylation loop region [posttranslational modification] 419947002249 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 419947002250 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 419947002251 active site 419947002252 phosphorylation site [posttranslational modification] 419947002253 intermolecular recognition site; other site 419947002254 dimerization interface [polypeptide binding]; other site 419947002255 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 419947002256 DNA binding residues [nucleotide binding] 419947002257 dimerization interface [polypeptide binding]; other site 419947002258 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 419947002259 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 419947002260 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 419947002261 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 419947002262 Multicopper oxidase; Region: Cu-oxidase; pfam00394 419947002263 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 419947002264 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 419947002265 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 419947002266 dimer interface [polypeptide binding]; other site 419947002267 pyridoxal 5'-phosphate binding site [chemical binding]; other site 419947002268 catalytic residue [active] 419947002269 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 419947002270 multidrug resistance protein MdtH; Provisional; Region: PRK11646 419947002271 putative substrate translocation pore; other site 419947002272 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 419947002273 short chain dehydrogenase; Provisional; Region: PRK05876 419947002274 classical (c) SDRs; Region: SDR_c; cd05233 419947002275 NAD(P) binding site [chemical binding]; other site 419947002276 active site 419947002277 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 419947002278 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 419947002279 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 419947002280 dimer interface [polypeptide binding]; other site 419947002281 PYR/PP interface [polypeptide binding]; other site 419947002282 TPP binding site [chemical binding]; other site 419947002283 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 419947002284 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 419947002285 TPP-binding site [chemical binding]; other site 419947002286 dimer interface [polypeptide binding]; other site 419947002287 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 419947002288 putative hydrophobic ligand binding site [chemical binding]; other site 419947002289 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 419947002290 CoA-transferase family III; Region: CoA_transf_3; pfam02515 419947002291 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 419947002292 putative hydrophobic ligand binding site [chemical binding]; other site 419947002293 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 419947002294 putative hydrophobic ligand binding site [chemical binding]; other site 419947002295 aminotransferase; Validated; Region: PRK07777 419947002296 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 419947002297 pyridoxal 5'-phosphate binding site [chemical binding]; other site 419947002298 homodimer interface [polypeptide binding]; other site 419947002299 catalytic residue [active] 419947002300 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 419947002301 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 419947002302 dimer interface [polypeptide binding]; other site 419947002303 active site 419947002304 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 419947002305 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 419947002306 substrate binding site [chemical binding]; other site 419947002307 oxyanion hole (OAH) forming residues; other site 419947002308 trimer interface [polypeptide binding]; other site 419947002309 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 419947002310 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 419947002311 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 419947002312 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 419947002313 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 419947002314 ATP binding site [chemical binding]; other site 419947002315 putative Mg++ binding site [ion binding]; other site 419947002316 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 419947002317 nucleotide binding region [chemical binding]; other site 419947002318 ATP-binding site [chemical binding]; other site 419947002319 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 419947002320 WYL domain; Region: WYL; pfam13280 419947002321 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 419947002322 trimer interface [polypeptide binding]; other site 419947002323 dimer interface [polypeptide binding]; other site 419947002324 putative active site [active] 419947002325 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 419947002326 MPT binding site; other site 419947002327 trimer interface [polypeptide binding]; other site 419947002328 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 419947002329 MoaE homodimer interface [polypeptide binding]; other site 419947002330 MoaD interaction [polypeptide binding]; other site 419947002331 active site residues [active] 419947002332 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 419947002333 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 419947002334 MoaE interaction surface [polypeptide binding]; other site 419947002335 MoeB interaction surface [polypeptide binding]; other site 419947002336 thiocarboxylated glycine; other site 419947002337 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 419947002338 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 419947002339 FeS/SAM binding site; other site 419947002340 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 419947002341 hypothetical protein; Provisional; Region: PRK11770 419947002342 Domain of unknown function (DUF307); Region: DUF307; pfam03733 419947002343 Domain of unknown function (DUF307); Region: DUF307; pfam03733 419947002344 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 419947002345 DNA-binding site [nucleotide binding]; DNA binding site 419947002346 RNA-binding motif; other site 419947002347 PE family; Region: PE; pfam00934 419947002348 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 419947002349 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 419947002350 active site 419947002351 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 419947002352 FIST N domain; Region: FIST; pfam08495 419947002353 FIST C domain; Region: FIST_C; pfam10442 419947002354 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 419947002355 H+ Antiporter protein; Region: 2A0121; TIGR00900 419947002356 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 419947002357 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947002358 PPE family; Region: PPE; pfam00823 419947002359 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 419947002360 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 419947002361 Protein of unknown function (DUF2530); Region: DUF2530; pfam10745 419947002362 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 419947002363 MarR family; Region: MarR; pfam01047 419947002364 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 419947002365 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 419947002366 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 419947002367 Protein of unknown function (DUF2537); Region: DUF2537; pfam10801 419947002368 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 419947002369 phosphoserine aminotransferase, putative; Region: serC_3; TIGR01366 419947002370 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 419947002371 catalytic residue [active] 419947002372 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 419947002373 Ferredoxin [Energy production and conversion]; Region: COG1146 419947002374 4Fe-4S binding domain; Region: Fer4; pfam00037 419947002375 ferredoxin-NADP+ reductase; Region: PLN02852 419947002376 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 419947002377 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 419947002378 putative dimer interface [polypeptide binding]; other site 419947002379 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 419947002380 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 419947002381 putative catalytic site [active] 419947002382 putative phosphate binding site [ion binding]; other site 419947002383 putative metal binding site [ion binding]; other site 419947002384 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 419947002385 dimer interface [polypeptide binding]; other site 419947002386 Citrate synthase; Region: Citrate_synt; pfam00285 419947002387 active site 419947002388 citrylCoA binding site [chemical binding]; other site 419947002389 oxalacetate/citrate binding site [chemical binding]; other site 419947002390 coenzyme A binding site [chemical binding]; other site 419947002391 catalytic triad [active] 419947002392 Predicted ATPase [General function prediction only]; Region: COG3903 419947002393 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 419947002394 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 419947002395 DNA binding residues [nucleotide binding] 419947002396 dimerization interface [polypeptide binding]; other site 419947002397 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 419947002398 cyclase homology domain; Region: CHD; cd07302 419947002399 nucleotidyl binding site; other site 419947002400 metal binding site [ion binding]; metal-binding site 419947002401 dimer interface [polypeptide binding]; other site 419947002402 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 419947002403 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 419947002404 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 419947002405 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 419947002406 AAA ATPase domain; Region: AAA_16; pfam13191 419947002407 Predicted ATPase [General function prediction only]; Region: COG3903 419947002408 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 419947002409 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 419947002410 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 419947002411 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 419947002412 dimer interface [polypeptide binding]; other site 419947002413 active site 419947002414 citrylCoA binding site [chemical binding]; other site 419947002415 NADH binding [chemical binding]; other site 419947002416 cationic pore residues; other site 419947002417 oxalacetate/citrate binding site [chemical binding]; other site 419947002418 coenzyme A binding site [chemical binding]; other site 419947002419 catalytic triad [active] 419947002420 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 419947002421 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 419947002422 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 419947002423 BON domain; Region: BON; pfam04972 419947002424 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 419947002425 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 419947002426 ligand binding site [chemical binding]; other site 419947002427 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 419947002428 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 419947002429 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 419947002430 dimerization interface [polypeptide binding]; other site 419947002431 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 419947002432 dimer interface [polypeptide binding]; other site 419947002433 phosphorylation site [posttranslational modification] 419947002434 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 419947002435 Mg2+ binding site [ion binding]; other site 419947002436 G-X-G motif; other site 419947002437 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 419947002438 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 419947002439 active site 419947002440 phosphorylation site [posttranslational modification] 419947002441 intermolecular recognition site; other site 419947002442 dimerization interface [polypeptide binding]; other site 419947002443 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 419947002444 DNA binding site [nucleotide binding] 419947002445 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 419947002446 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; COG0825 419947002447 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 419947002448 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 419947002449 substrate binding site [chemical binding]; other site 419947002450 oxyanion hole (OAH) forming residues; other site 419947002451 trimer interface [polypeptide binding]; other site 419947002452 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 419947002453 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 419947002454 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 419947002455 Beta-lactamase; Region: Beta-lactamase; pfam00144 419947002456 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 419947002457 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 419947002458 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 419947002459 Soluble P-type ATPase [General function prediction only]; Region: COG4087 419947002460 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 419947002461 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 419947002462 hydrophobic ligand binding site; other site 419947002463 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 419947002464 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 419947002465 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 419947002466 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 419947002467 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 419947002468 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 419947002469 acetyl-CoA acetyltransferase; Provisional; Region: PRK06289 419947002470 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 419947002471 active site 419947002472 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947002473 PPE family; Region: PPE; pfam00823 419947002474 PE family; Region: PE; pfam00934 419947002475 BCCT family transporter; Region: BCCT; pfam02028 419947002476 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 419947002477 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 419947002478 Coenzyme A binding pocket [chemical binding]; other site 419947002479 Transposase, Mutator family; Region: Transposase_mut; pfam00872 419947002480 MULE transposase domain; Region: MULE; pfam10551 419947002481 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 419947002482 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 419947002483 catalytic residues [active] 419947002484 catalytic nucleophile [active] 419947002485 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 419947002486 Probable transposase; Region: OrfB_IS605; pfam01385 419947002487 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 419947002488 putative active site pocket [active] 419947002489 dimerization interface [polypeptide binding]; other site 419947002490 putative catalytic residue [active] 419947002491 Phage-related replication protein [General function prediction only]; Region: COG4195 419947002492 manganese transport protein MntH; Reviewed; Region: PRK00701 419947002493 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 419947002494 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 419947002495 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 419947002496 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 419947002497 short chain dehydrogenase; Provisional; Region: PRK07814 419947002498 classical (c) SDRs; Region: SDR_c; cd05233 419947002499 NAD(P) binding site [chemical binding]; other site 419947002500 active site 419947002501 phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975 419947002502 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 419947002503 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 419947002504 dimer interface [polypeptide binding]; other site 419947002505 conserved gate region; other site 419947002506 putative PBP binding loops; other site 419947002507 ABC-ATPase subunit interface; other site 419947002508 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 419947002509 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 419947002510 dimer interface [polypeptide binding]; other site 419947002511 conserved gate region; other site 419947002512 putative PBP binding loops; other site 419947002513 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 419947002514 ABC-ATPase subunit interface; other site 419947002515 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 419947002516 Catalytic domain of Protein Kinases; Region: PKc; cd00180 419947002517 active site 419947002518 ATP binding site [chemical binding]; other site 419947002519 substrate binding site [chemical binding]; other site 419947002520 activation loop (A-loop); other site 419947002521 Uncharacterized conserved protein [Function unknown]; Region: COG3391 419947002522 NHL repeat; Region: NHL; pfam01436 419947002523 NHL repeat; Region: NHL; pfam01436 419947002524 NHL repeat; Region: NHL; pfam01436 419947002525 NHL repeat; Region: NHL; pfam01436 419947002526 NHL repeat; Region: NHL; pfam01436 419947002527 PBP superfamily domain; Region: PBP_like_2; cl17296 419947002528 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14271 419947002529 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 419947002530 Walker A/P-loop; other site 419947002531 ATP binding site [chemical binding]; other site 419947002532 Q-loop/lid; other site 419947002533 ABC transporter signature motif; other site 419947002534 Walker B; other site 419947002535 D-loop; other site 419947002536 H-loop/switch region; other site 419947002537 phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975 419947002538 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 419947002539 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 419947002540 dimer interface [polypeptide binding]; other site 419947002541 conserved gate region; other site 419947002542 putative PBP binding loops; other site 419947002543 ABC-ATPase subunit interface; other site 419947002544 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 419947002545 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 419947002546 dimer interface [polypeptide binding]; other site 419947002547 conserved gate region; other site 419947002548 putative PBP binding loops; other site 419947002549 ABC-ATPase subunit interface; other site 419947002550 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 419947002551 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 419947002552 putative DNA binding site [nucleotide binding]; other site 419947002553 putative homodimer interface [polypeptide binding]; other site 419947002554 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 419947002555 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 419947002556 nucleotide binding site [chemical binding]; other site 419947002557 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 419947002558 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 419947002559 active site 419947002560 DNA binding site [nucleotide binding] 419947002561 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 419947002562 DNA binding site [nucleotide binding] 419947002563 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 419947002564 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 419947002565 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 419947002566 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 419947002567 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 419947002568 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 419947002569 anti sigma factor interaction site; other site 419947002570 regulatory phosphorylation site [posttranslational modification]; other site 419947002571 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 419947002572 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 419947002573 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 419947002574 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 419947002575 short chain dehydrogenase; Provisional; Region: PRK08251 419947002576 classical (c) SDR, subgroup 6; Region: SDR_c6; cd05350 419947002577 putative NAD(P) binding site [chemical binding]; other site 419947002578 active site 419947002579 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 419947002580 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 419947002581 active site 419947002582 dimer interface [polypeptide binding]; other site 419947002583 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 419947002584 dimer interface [polypeptide binding]; other site 419947002585 active site 419947002586 hypothetical protein; Provisional; Region: PRK07857 419947002587 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 419947002588 Part of AAA domain; Region: AAA_19; pfam13245 419947002589 Family description; Region: UvrD_C_2; pfam13538 419947002590 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 419947002591 Peptidase family M23; Region: Peptidase_M23; pfam01551 419947002592 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 419947002593 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 419947002594 CoA-ligase; Region: Ligase_CoA; pfam00549 419947002595 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 419947002596 CoA binding domain; Region: CoA_binding; smart00881 419947002597 CoA-ligase; Region: Ligase_CoA; pfam00549 419947002598 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 419947002599 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 419947002600 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 419947002601 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 419947002602 active site 419947002603 substrate binding site [chemical binding]; other site 419947002604 cosubstrate binding site; other site 419947002605 catalytic site [active] 419947002606 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 419947002607 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 419947002608 purine monophosphate binding site [chemical binding]; other site 419947002609 dimer interface [polypeptide binding]; other site 419947002610 putative catalytic residues [active] 419947002611 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 419947002612 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 419947002613 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 419947002614 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 419947002615 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 419947002616 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 419947002617 metal ion-dependent adhesion site (MIDAS); other site 419947002618 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 419947002619 homotetrameric interface [polypeptide binding]; other site 419947002620 putative active site [active] 419947002621 metal binding site [ion binding]; metal-binding site 419947002622 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 419947002623 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 419947002624 Thermus thermophilus CsoR, a Cu(I)-sensing transcriptional regulator, and related domains; this domain family was previously known as part of DUF156; Region: TthCsoR-like_DUF156; cd10151 419947002625 putative homodimer interface [polypeptide binding]; other site 419947002626 putative homotetramer interface [polypeptide binding]; other site 419947002627 allosteric switch controlling residues; other site 419947002628 putative metal binding site [ion binding]; other site 419947002629 putative homodimer-homodimer interface [polypeptide binding]; other site 419947002630 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 419947002631 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 419947002632 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 419947002633 Soluble P-type ATPase [General function prediction only]; Region: COG4087 419947002634 enoyl-CoA hydratase; Provisional; Region: PRK07827 419947002635 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 419947002636 substrate binding site [chemical binding]; other site 419947002637 oxyanion hole (OAH) forming residues; other site 419947002638 trimer interface [polypeptide binding]; other site 419947002639 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 419947002640 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 419947002641 active site 419947002642 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 419947002643 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 419947002644 ATP-grasp domain; Region: ATP-grasp_4; cl17255 419947002645 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 419947002646 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 419947002647 carboxyltransferase (CT) interaction site; other site 419947002648 biotinylation site [posttranslational modification]; other site 419947002649 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 419947002650 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 419947002651 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 419947002652 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 419947002653 active site 419947002654 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 419947002655 PE family; Region: PE; pfam00934 419947002656 PE family; Region: PE; pfam00934 419947002657 Uncharacterized conserved protein [Function unknown]; Region: COG3391 419947002658 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 419947002659 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 419947002660 PE family; Region: PE; pfam00934 419947002661 Uncharacterized conserved protein [Function unknown]; Region: COG3391 419947002662 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 419947002663 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 419947002664 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 419947002665 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 419947002666 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 419947002667 active site 419947002668 phosphorylation site [posttranslational modification] 419947002669 intermolecular recognition site; other site 419947002670 dimerization interface [polypeptide binding]; other site 419947002671 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 419947002672 DNA binding site [nucleotide binding] 419947002673 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 419947002674 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 419947002675 dimerization interface [polypeptide binding]; other site 419947002676 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 419947002677 dimer interface [polypeptide binding]; other site 419947002678 phosphorylation site [posttranslational modification] 419947002679 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 419947002680 ATP binding site [chemical binding]; other site 419947002681 Mg2+ binding site [ion binding]; other site 419947002682 G-X-G motif; other site 419947002683 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 419947002684 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 419947002685 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 419947002686 MPT binding site; other site 419947002687 trimer interface [polypeptide binding]; other site 419947002688 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 419947002689 Large-conductance mechanosensitive channel, MscL; Region: MscL; pfam01741 419947002690 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 419947002691 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 419947002692 Walker A/P-loop; other site 419947002693 ATP binding site [chemical binding]; other site 419947002694 Q-loop/lid; other site 419947002695 ABC transporter signature motif; other site 419947002696 Walker B; other site 419947002697 D-loop; other site 419947002698 H-loop/switch region; other site 419947002699 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 419947002700 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 419947002701 FtsX-like permease family; Region: FtsX; pfam02687 419947002702 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 419947002703 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 419947002704 FtsX-like permease family; Region: FtsX; pfam02687 419947002705 Predicted secreted hydrolase [General function prediction only]; Region: COG5621 419947002706 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 419947002707 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 419947002708 substrate binding pocket [chemical binding]; other site 419947002709 chain length determination region; other site 419947002710 substrate-Mg2+ binding site; other site 419947002711 catalytic residues [active] 419947002712 aspartate-rich region 1; other site 419947002713 active site lid residues [active] 419947002714 aspartate-rich region 2; other site 419947002715 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 419947002716 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2331 419947002717 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 419947002718 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 419947002719 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 419947002720 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 419947002721 active site 419947002722 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 419947002723 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 419947002724 dimer interface [polypeptide binding]; other site 419947002725 putative functional site; other site 419947002726 putative MPT binding site; other site 419947002727 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 419947002728 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 419947002729 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 419947002730 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 419947002731 ligand binding site [chemical binding]; other site 419947002732 flexible hinge region; other site 419947002733 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 419947002734 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 419947002735 Coenzyme A binding pocket [chemical binding]; other site 419947002736 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 419947002737 arginine deiminase; Provisional; Region: PRK01388 419947002738 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 419947002739 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 419947002740 Predicted methyltransferases [General function prediction only]; Region: COG0313 419947002741 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 419947002742 putative SAM binding site [chemical binding]; other site 419947002743 putative homodimer interface [polypeptide binding]; other site 419947002744 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 419947002745 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 419947002746 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 419947002747 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 419947002748 active site 419947002749 HIGH motif; other site 419947002750 KMSKS motif; other site 419947002751 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 419947002752 tRNA binding surface [nucleotide binding]; other site 419947002753 anticodon binding site; other site 419947002754 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 419947002755 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 419947002756 active site 419947002757 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 419947002758 Domain of unknown function (DUF348); Region: DUF348; pfam03990 419947002759 Domain of unknown function (DUF348); Region: DUF348; pfam03990 419947002760 G5 domain; Region: G5; pfam07501 419947002761 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 419947002762 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 419947002763 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 419947002764 S-adenosylmethionine binding site [chemical binding]; other site 419947002765 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 419947002766 Increased loss of mitochondrial DNA protein 1; Region: Ilm1; pfam10311 419947002767 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 419947002768 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 419947002769 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 419947002770 acyl-activating enzyme (AAE) consensus motif; other site 419947002771 AMP binding site [chemical binding]; other site 419947002772 active site 419947002773 CoA binding site [chemical binding]; other site 419947002774 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 419947002775 putative active site [active] 419947002776 catalytic residue [active] 419947002777 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 419947002778 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 419947002779 5S rRNA interface [nucleotide binding]; other site 419947002780 CTC domain interface [polypeptide binding]; other site 419947002781 L16 interface [polypeptide binding]; other site 419947002782 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 419947002783 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 419947002784 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 419947002785 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 419947002786 active site 419947002787 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 419947002788 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 419947002789 Substrate binding site; other site 419947002790 Mg++ binding site; other site 419947002791 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 419947002792 active site 419947002793 substrate binding site [chemical binding]; other site 419947002794 CoA binding site [chemical binding]; other site 419947002795 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 419947002796 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 419947002797 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 419947002798 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 419947002799 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 419947002800 ATP binding site [chemical binding]; other site 419947002801 putative Mg++ binding site [ion binding]; other site 419947002802 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 419947002803 nucleotide binding region [chemical binding]; other site 419947002804 ATP-binding site [chemical binding]; other site 419947002805 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 419947002806 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 419947002807 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 419947002808 homodimer interface [polypeptide binding]; other site 419947002809 metal binding site [ion binding]; metal-binding site 419947002810 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 419947002811 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 419947002812 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 419947002813 N-acetyl-D-glucosamine binding site [chemical binding]; other site 419947002814 enolase; Provisional; Region: eno; PRK00077 419947002815 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 419947002816 dimer interface [polypeptide binding]; other site 419947002817 metal binding site [ion binding]; metal-binding site 419947002818 substrate binding pocket [chemical binding]; other site 419947002819 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 419947002820 Septum formation initiator; Region: DivIC; pfam04977 419947002821 Uncharacterized conserved protein [Function unknown]; Region: COG1507 419947002822 exopolyphosphatase; Region: exo_poly_only; TIGR03706 419947002823 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 419947002824 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 419947002825 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 419947002826 active site 419947002827 phosphorylation site [posttranslational modification] 419947002828 intermolecular recognition site; other site 419947002829 dimerization interface [polypeptide binding]; other site 419947002830 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 419947002831 DNA binding site [nucleotide binding] 419947002832 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 419947002833 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 419947002834 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 419947002835 Ligand Binding Site [chemical binding]; other site 419947002836 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 419947002837 dimer interface [polypeptide binding]; other site 419947002838 phosphorylation site [posttranslational modification] 419947002839 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 419947002840 ATP binding site [chemical binding]; other site 419947002841 Mg2+ binding site [ion binding]; other site 419947002842 G-X-G motif; other site 419947002843 K+-transporting ATPase, KdpA; Region: kdpA; TIGR00680 419947002844 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 419947002845 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 419947002846 Soluble P-type ATPase [General function prediction only]; Region: COG4087 419947002847 potassium-transporting ATPase subunit C; Provisional; Region: PRK14001 419947002848 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 419947002849 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 419947002850 dimer interface [polypeptide binding]; other site 419947002851 phosphorylation site [posttranslational modification] 419947002852 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 419947002853 ATP binding site [chemical binding]; other site 419947002854 Mg2+ binding site [ion binding]; other site 419947002855 G-X-G motif; other site 419947002856 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 419947002857 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 419947002858 active site 419947002859 phosphorylation site [posttranslational modification] 419947002860 intermolecular recognition site; other site 419947002861 dimerization interface [polypeptide binding]; other site 419947002862 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 419947002863 DNA binding site [nucleotide binding] 419947002864 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 419947002865 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 419947002866 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 419947002867 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 419947002868 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 419947002869 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947002870 PPE family; Region: PPE; pfam00823 419947002871 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 419947002872 PE family; Region: PE; pfam00934 419947002873 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 419947002874 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 419947002875 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 419947002876 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 419947002877 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 419947002878 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 419947002879 Predicted transcriptional regulator [Transcription]; Region: COG5340 419947002880 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 419947002881 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 419947002882 Transposase, Mutator family; Region: Transposase_mut; pfam00872 419947002883 MULE transposase domain; Region: MULE; pfam10551 419947002884 Transcriptional regulators [Transcription]; Region: MarR; COG1846 419947002885 MarR family; Region: MarR_2; pfam12802 419947002886 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 419947002887 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 419947002888 NAD(P) binding site [chemical binding]; other site 419947002889 active site 419947002890 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 419947002891 Helix-turn-helix domain; Region: HTH_17; pfam12728 419947002892 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 419947002893 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 419947002894 active site 419947002895 Int/Topo IB signature motif; other site 419947002896 Domain of unknown function (DUF427); Region: DUF427; cl00998 419947002897 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 419947002898 Domain of unknown function (DUF222); Region: DUF222; pfam02720 419947002899 Uncharacterized conserved protein [Function unknown]; Region: COG3391 419947002900 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 419947002901 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 419947002902 dimer interface [polypeptide binding]; other site 419947002903 acyl-activating enzyme (AAE) consensus motif; other site 419947002904 putative active site [active] 419947002905 AMP binding site [chemical binding]; other site 419947002906 putative CoA binding site [chemical binding]; other site 419947002907 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 419947002908 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 419947002909 hydrophobic ligand binding site; other site 419947002910 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 419947002911 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 419947002912 putative active site [active] 419947002913 putative dimer interface [polypeptide binding]; other site 419947002914 Patatin-like phospholipase; Region: Patatin; pfam01734 419947002915 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 419947002916 nucleophile elbow; other site 419947002917 hypothetical protein; Provisional; Region: PRK10279 419947002918 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 419947002919 active site 419947002920 nucleophile elbow; other site 419947002921 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 419947002922 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 419947002923 active site residue [active] 419947002924 PE family; Region: PE; pfam00934 419947002925 PE family; Region: PE; pfam00934 419947002926 Predicted membrane protein [Function unknown]; Region: COG4425 419947002927 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 419947002928 enoyl-CoA hydratase; Provisional; Region: PRK05862 419947002929 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 419947002930 substrate binding site [chemical binding]; other site 419947002931 oxyanion hole (OAH) forming residues; other site 419947002932 trimer interface [polypeptide binding]; other site 419947002933 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 419947002934 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 419947002935 substrate binding site [chemical binding]; other site 419947002936 oxyanion hole (OAH) forming residues; other site 419947002937 trimer interface [polypeptide binding]; other site 419947002938 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 419947002939 Predicted membrane protein [Function unknown]; Region: COG4760 419947002940 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 419947002941 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 419947002942 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 419947002943 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 419947002944 dimer interface [polypeptide binding]; other site 419947002945 active site 419947002946 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 419947002947 active site 419947002948 catalytic triad [active] 419947002949 oxyanion hole [active] 419947002950 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 419947002951 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 419947002952 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 419947002953 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 419947002954 dimer interface [polypeptide binding]; other site 419947002955 pyridoxal 5'-phosphate binding site [chemical binding]; other site 419947002956 catalytic residue [active] 419947002957 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 419947002958 RDD family; Region: RDD; pfam06271 419947002959 cystathionine gamma-synthase; Provisional; Region: PRK07811 419947002960 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 419947002961 homodimer interface [polypeptide binding]; other site 419947002962 substrate-cofactor binding pocket; other site 419947002963 pyridoxal 5'-phosphate binding site [chemical binding]; other site 419947002964 catalytic residue [active] 419947002965 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 419947002966 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 419947002967 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 419947002968 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 419947002969 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 419947002970 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 419947002971 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 419947002972 catalytic residues [active] 419947002973 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 419947002974 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 419947002975 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 419947002976 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 419947002977 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 419947002978 catalytic residue [active] 419947002979 putative FPP diphosphate binding site; other site 419947002980 putative FPP binding hydrophobic cleft; other site 419947002981 dimer interface [polypeptide binding]; other site 419947002982 putative IPP diphosphate binding site; other site 419947002983 PE family; Region: PE; pfam00934 419947002984 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 419947002985 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 419947002986 putative IPP diphosphate binding site; other site 419947002987 PE family; Region: PE; pfam00934 419947002988 Glycosyl hydrolase family 12; Region: Glyco_hydro_12; pfam01670 419947002989 PE family; Region: PE; pfam00934 419947002990 pantothenate kinase; Provisional; Region: PRK05439 419947002991 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 419947002992 ATP-binding site [chemical binding]; other site 419947002993 CoA-binding site [chemical binding]; other site 419947002994 Mg2+-binding site [ion binding]; other site 419947002995 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 419947002996 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 419947002997 dimer interface [polypeptide binding]; other site 419947002998 active site 419947002999 glycine-pyridoxal phosphate binding site [chemical binding]; other site 419947003000 folate binding site [chemical binding]; other site 419947003001 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 419947003002 dinuclear metal binding motif [ion binding]; other site 419947003003 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 419947003004 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 419947003005 putative active site [active] 419947003006 PhoH-like protein; Region: PhoH; pfam02562 419947003007 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 419947003008 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 419947003009 NodB motif; other site 419947003010 active site 419947003011 catalytic site [active] 419947003012 metal binding site [ion binding]; metal-binding site 419947003013 fumarate hydratase; Reviewed; Region: fumC; PRK00485 419947003014 Class II fumarases; Region: Fumarase_classII; cd01362 419947003015 active site 419947003016 tetramer interface [polypeptide binding]; other site 419947003017 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 419947003018 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 419947003019 putative active site [active] 419947003020 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 419947003021 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 419947003022 Domain of unknown function DUF20; Region: UPF0118; pfam01594 419947003023 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 419947003024 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 419947003025 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 419947003026 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 419947003027 3beta-hydroxysteroid dehydrogenases (3b-HSD)-like, extended (e) SDRs; Region: 3b-HSD-like_SDR_e; cd05241 419947003028 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 419947003029 putative NAD(P) binding site [chemical binding]; other site 419947003030 active site 419947003031 putative substrate binding site [chemical binding]; other site 419947003032 exodeoxyribonuclease VII, small subunit; Region: xseB; TIGR01280 419947003033 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 419947003034 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 419947003035 generic binding surface II; other site 419947003036 generic binding surface I; other site 419947003037 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 419947003038 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 419947003039 Yip1 domain; Region: Yip1; pfam04893 419947003040 GTP-binding protein YchF; Reviewed; Region: PRK09601 419947003041 YchF GTPase; Region: YchF; cd01900 419947003042 G1 box; other site 419947003043 GTP/Mg2+ binding site [chemical binding]; other site 419947003044 Switch I region; other site 419947003045 G2 box; other site 419947003046 Switch II region; other site 419947003047 G3 box; other site 419947003048 G4 box; other site 419947003049 G5 box; other site 419947003050 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 419947003051 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 419947003052 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487 419947003053 putative active site [active] 419947003054 Uncharacterized conserved protein [Function unknown]; Region: COG1359 419947003055 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 419947003056 cyclase homology domain; Region: CHD; cd07302 419947003057 nucleotidyl binding site; other site 419947003058 metal binding site [ion binding]; metal-binding site 419947003059 dimer interface [polypeptide binding]; other site 419947003060 glucose-6-phosphate 1-dehydrogenase; Region: zwf; TIGR00871 419947003061 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 419947003062 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 419947003063 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 419947003064 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd_rel; TIGR00872 419947003065 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 419947003066 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 419947003067 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 419947003068 pyruvate phosphate dikinase; Provisional; Region: PRK05878 419947003069 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 419947003070 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 419947003071 Domain of unknown function (DUF222); Region: DUF222; pfam02720 419947003072 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 419947003073 active site 419947003074 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 419947003075 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 419947003076 non-specific DNA binding site [nucleotide binding]; other site 419947003077 salt bridge; other site 419947003078 sequence-specific DNA binding site [nucleotide binding]; other site 419947003079 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 419947003080 Domain of unknown function (DUF955); Region: DUF955; pfam06114 419947003081 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 419947003082 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 419947003083 citrate synthase; Provisional; Region: PRK14033 419947003084 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 419947003085 oxalacetate binding site [chemical binding]; other site 419947003086 citrylCoA binding site [chemical binding]; other site 419947003087 coenzyme A binding site [chemical binding]; other site 419947003088 catalytic triad [active] 419947003089 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 419947003090 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 419947003091 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 419947003092 THF binding site; other site 419947003093 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 419947003094 substrate binding site [chemical binding]; other site 419947003095 THF binding site; other site 419947003096 zinc-binding site [ion binding]; other site 419947003097 PPE family; Region: PPE; pfam00823 419947003098 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 419947003099 active site 419947003100 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 419947003101 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 419947003102 substrate binding site [chemical binding]; other site 419947003103 oxyanion hole (OAH) forming residues; other site 419947003104 enoyl-CoA hydratase; Provisional; Region: PRK06494 419947003105 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 419947003106 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 419947003107 CAAX protease self-immunity; Region: Abi; pfam02517 419947003108 enoyl-CoA hydratase; Provisional; Region: PRK06688 419947003109 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 419947003110 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 419947003111 trimer interface [polypeptide binding]; other site 419947003112 enoyl-CoA hydratase; Provisional; Region: PRK06688 419947003113 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 419947003114 substrate binding site [chemical binding]; other site 419947003115 oxyanion hole (OAH) forming residues; other site 419947003116 trimer interface [polypeptide binding]; other site 419947003117 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 419947003118 CoA-transferase family III; Region: CoA_transf_3; pfam02515 419947003119 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 419947003120 NAD binding site [chemical binding]; other site 419947003121 homodimer interface [polypeptide binding]; other site 419947003122 homotetramer interface [polypeptide binding]; other site 419947003123 active site 419947003124 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 419947003125 MMPL family; Region: MMPL; pfam03176 419947003126 Domain of unknown function (DUF222); Region: DUF222; pfam02720 419947003127 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 419947003128 active site 419947003129 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 419947003130 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 419947003131 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 419947003132 NAD-dependent deacetylase; Provisional; Region: PRK00481 419947003133 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 419947003134 NAD+ binding site [chemical binding]; other site 419947003135 substrate binding site [chemical binding]; other site 419947003136 Zn binding site [ion binding]; other site 419947003137 Predicted transcriptional regulators [Transcription]; Region: COG1725 419947003138 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 419947003139 DNA-binding site [nucleotide binding]; DNA binding site 419947003140 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 419947003141 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 419947003142 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 419947003143 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 419947003144 uncharacterized HhH-GPD family protein; Region: TIGR03252 419947003145 minor groove reading motif; other site 419947003146 helix-hairpin-helix signature motif; other site 419947003147 mannosyltransferase; Provisional; Region: pimE; PRK13375 419947003148 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 419947003149 aromatic arch; other site 419947003150 DCoH dimer interaction site [polypeptide binding]; other site 419947003151 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 419947003152 DCoH tetramer interaction site [polypeptide binding]; other site 419947003153 substrate binding site [chemical binding]; other site 419947003154 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 419947003155 active site 419947003156 8-oxo-dGMP binding site [chemical binding]; other site 419947003157 nudix motif; other site 419947003158 metal binding site [ion binding]; metal-binding site 419947003159 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 419947003160 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 419947003161 [4Fe-4S] binding site [ion binding]; other site 419947003162 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 419947003163 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 419947003164 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 419947003165 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 419947003166 molybdopterin cofactor binding site; other site 419947003167 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 419947003168 nitrate reductase molybdenum cofactor assembly chaperone; Region: narJ; TIGR00684 419947003169 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 419947003170 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 419947003171 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 419947003172 G1 box; other site 419947003173 putative GEF interaction site [polypeptide binding]; other site 419947003174 GTP/Mg2+ binding site [chemical binding]; other site 419947003175 Switch I region; other site 419947003176 G2 box; other site 419947003177 G3 box; other site 419947003178 Switch II region; other site 419947003179 G4 box; other site 419947003180 G5 box; other site 419947003181 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 419947003182 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 419947003183 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 419947003184 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 419947003185 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 419947003186 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 419947003187 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 419947003188 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947003189 PPE family; Region: PPE; pfam00823 419947003190 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 419947003191 PE family; Region: PE; pfam00934 419947003192 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 419947003193 PE family; Region: PE; pfam00934 419947003194 FO synthase; Reviewed; Region: fbiC; PRK09234 419947003195 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 419947003196 FeS/SAM binding site; other site 419947003197 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 419947003198 FeS/SAM binding site; other site 419947003199 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 419947003200 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 419947003201 active site 419947003202 FMN binding site [chemical binding]; other site 419947003203 2,4-decadienoyl-CoA binding site; other site 419947003204 catalytic residue [active] 419947003205 4Fe-4S cluster binding site [ion binding]; other site 419947003206 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 419947003207 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 419947003208 Predicted transcriptional regulators [Transcription]; Region: COG1695 419947003209 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 419947003210 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 419947003211 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 419947003212 4Fe-4S binding domain; Region: Fer4; pfam00037 419947003213 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 419947003214 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 419947003215 pyridoxal 5'-phosphate binding site [chemical binding]; other site 419947003216 homodimer interface [polypeptide binding]; other site 419947003217 catalytic residue [active] 419947003218 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 419947003219 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 419947003220 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 419947003221 ATP binding site [chemical binding]; other site 419947003222 putative Mg++ binding site [ion binding]; other site 419947003223 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 419947003224 ATP-binding site [chemical binding]; other site 419947003225 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 419947003226 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 419947003227 active site 419947003228 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 419947003229 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 419947003230 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 419947003231 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 419947003232 Enoylreductase; Region: PKS_ER; smart00829 419947003233 NAD(P) binding site [chemical binding]; other site 419947003234 KR domain; Region: KR; pfam08659 419947003235 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 419947003236 putative NADP binding site [chemical binding]; other site 419947003237 active site 419947003238 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 419947003239 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 419947003240 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 419947003241 PE-PPE domain; Region: PE-PPE; pfam08237 419947003242 acyl-CoA synthetase; Validated; Region: PRK05850 419947003243 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 419947003244 acyl-activating enzyme (AAE) consensus motif; other site 419947003245 active site 419947003246 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 419947003247 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 419947003248 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 419947003249 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 419947003250 Glutamate binding site [chemical binding]; other site 419947003251 NAD binding site [chemical binding]; other site 419947003252 catalytic residues [active] 419947003253 Proline dehydrogenase; Region: Pro_dh; pfam01619 419947003254 RNA polymerase sigma factor SigI; Provisional; Region: sigI; PRK09635 419947003255 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 419947003256 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 419947003257 DNA binding residues [nucleotide binding] 419947003258 haloalkane dehalogenase; Provisional; Region: PRK03204 419947003259 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 419947003260 catalytic site [active] 419947003261 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 419947003262 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 419947003263 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 419947003264 PGAP1-like protein; Region: PGAP1; pfam07819 419947003265 acyl-CoA synthetase; Validated; Region: PRK07787 419947003266 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 419947003267 acyl-activating enzyme (AAE) consensus motif; other site 419947003268 AMP binding site [chemical binding]; other site 419947003269 active site 419947003270 CoA binding site [chemical binding]; other site 419947003271 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 419947003272 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 419947003273 PE family; Region: PE; pfam00934 419947003274 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947003275 PPE family; Region: PPE; pfam00823 419947003276 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 419947003277 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 419947003278 Transposase, Mutator family; Region: Transposase_mut; pfam00872 419947003279 MULE transposase domain; Region: MULE; pfam10551 419947003280 metabolite-proton symporter; Region: 2A0106; TIGR00883 419947003281 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 419947003282 putative substrate translocation pore; other site 419947003283 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 419947003284 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 419947003285 putative trimer interface [polypeptide binding]; other site 419947003286 putative CoA binding site [chemical binding]; other site 419947003287 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 419947003288 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 419947003289 metal binding site [ion binding]; metal-binding site 419947003290 putative dimer interface [polypeptide binding]; other site 419947003291 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 419947003292 TIGR00730 family protein; Region: TIGR00730 419947003293 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 419947003294 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 419947003295 acyl-activating enzyme (AAE) consensus motif; other site 419947003296 putative AMP binding site [chemical binding]; other site 419947003297 putative active site [active] 419947003298 putative CoA binding site [chemical binding]; other site 419947003299 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 419947003300 dihydropteroate synthase; Region: DHPS; TIGR01496 419947003301 substrate binding pocket [chemical binding]; other site 419947003302 dimer interface [polypeptide binding]; other site 419947003303 inhibitor binding site; inhibition site 419947003304 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 419947003305 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 419947003306 DivIVA domain; Region: DivI1A_domain; TIGR03544 419947003307 DNA-3-methyladenine glycosylase I; Region: tag; TIGR00624 419947003308 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 419947003309 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 419947003310 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 419947003311 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 419947003312 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 419947003313 ligand binding site; other site 419947003314 oligomer interface; other site 419947003315 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 419947003316 dimer interface [polypeptide binding]; other site 419947003317 N-terminal domain interface [polypeptide binding]; other site 419947003318 sulfate 1 binding site; other site 419947003319 PE family; Region: PE; pfam00934 419947003320 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 419947003321 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 419947003322 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 419947003323 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 419947003324 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 419947003325 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 419947003326 Walker A/P-loop; other site 419947003327 ATP binding site [chemical binding]; other site 419947003328 Q-loop/lid; other site 419947003329 ABC transporter signature motif; other site 419947003330 Walker B; other site 419947003331 D-loop; other site 419947003332 H-loop/switch region; other site 419947003333 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 419947003334 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 419947003335 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 419947003336 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 419947003337 S-adenosylmethionine binding site [chemical binding]; other site 419947003338 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 419947003339 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 419947003340 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 419947003341 DNA binding residues [nucleotide binding] 419947003342 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 419947003343 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 419947003344 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 419947003345 protein binding site [polypeptide binding]; other site 419947003346 sec-independent translocase; Provisional; Region: PRK03100 419947003347 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 419947003348 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 419947003349 active site 419947003350 motif I; other site 419947003351 motif II; other site 419947003352 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 419947003353 Predicted membrane protein [Function unknown]; Region: COG3428 419947003354 Bacterial PH domain; Region: DUF304; pfam03703 419947003355 Uncharacterized conserved protein [Function unknown]; Region: COG3402 419947003356 Domain of unknown function DUF59; Region: DUF59; cl00941 419947003357 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 419947003358 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 419947003359 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 419947003360 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 419947003361 N-acetyl-D-glucosamine binding site [chemical binding]; other site 419947003362 catalytic residue [active] 419947003363 Predicted membrane protein [Function unknown]; Region: COG4420 419947003364 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 419947003365 MgtE intracellular N domain; Region: MgtE_N; smart00924 419947003366 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 419947003367 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 419947003368 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 419947003369 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 419947003370 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 419947003371 dimer interface [polypeptide binding]; other site 419947003372 conserved gate region; other site 419947003373 putative PBP binding loops; other site 419947003374 ABC-ATPase subunit interface; other site 419947003375 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 419947003376 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 419947003377 dimer interface [polypeptide binding]; other site 419947003378 conserved gate region; other site 419947003379 ABC-ATPase subunit interface; other site 419947003380 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 419947003381 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 419947003382 Walker A/P-loop; other site 419947003383 ATP binding site [chemical binding]; other site 419947003384 Q-loop/lid; other site 419947003385 ABC transporter signature motif; other site 419947003386 Walker B; other site 419947003387 D-loop; other site 419947003388 H-loop/switch region; other site 419947003389 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 419947003390 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 419947003391 oligomer interface [polypeptide binding]; other site 419947003392 metal binding site [ion binding]; metal-binding site 419947003393 metal binding site [ion binding]; metal-binding site 419947003394 putative Cl binding site [ion binding]; other site 419947003395 basic sphincter; other site 419947003396 hydrophobic gate; other site 419947003397 periplasmic entrance; other site 419947003398 malate dehydrogenase; Provisional; Region: PRK05442 419947003399 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 419947003400 NAD(P) binding site [chemical binding]; other site 419947003401 dimer interface [polypeptide binding]; other site 419947003402 malate binding site [chemical binding]; other site 419947003403 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 419947003404 PE family; Region: PE; pfam00934 419947003405 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 419947003406 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 419947003407 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 419947003408 NAD(P) binding site [chemical binding]; other site 419947003409 active site 419947003410 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 419947003411 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 419947003412 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 419947003413 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 419947003414 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 419947003415 TPP-binding site [chemical binding]; other site 419947003416 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 419947003417 dimer interface [polypeptide binding]; other site 419947003418 PYR/PP interface [polypeptide binding]; other site 419947003419 TPP binding site [chemical binding]; other site 419947003420 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 419947003421 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 419947003422 putative substrate translocation pore; other site 419947003423 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 419947003424 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 419947003425 RNase_H superfamily; Region: RNase_H_2; pfam13482 419947003426 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 419947003427 Part of AAA domain; Region: AAA_19; pfam13245 419947003428 AAA domain; Region: AAA_12; pfam13087 419947003429 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 419947003430 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 419947003431 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 419947003432 ATP binding site [chemical binding]; other site 419947003433 Mg++ binding site [ion binding]; other site 419947003434 motif III; other site 419947003435 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 419947003436 nucleotide binding region [chemical binding]; other site 419947003437 ATP-binding site [chemical binding]; other site 419947003438 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 419947003439 putative RNA binding site [nucleotide binding]; other site 419947003440 Acyltransferase family; Region: Acyl_transf_3; pfam01757 419947003441 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 419947003442 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 419947003443 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 419947003444 FAD binding domain; Region: FAD_binding_4; pfam01565 419947003445 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 419947003446 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 419947003447 H+ Antiporter protein; Region: 2A0121; TIGR00900 419947003448 putative substrate translocation pore; other site 419947003449 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 419947003450 Fe-S cluster binding site [ion binding]; other site 419947003451 DNA binding site [nucleotide binding] 419947003452 active site 419947003453 hypothetical protein; Validated; Region: PRK05868 419947003454 hypothetical protein; Provisional; Region: PRK07236 419947003455 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 419947003456 Domain of unknown function (DUF385); Region: DUF385; pfam04075 419947003457 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 419947003458 HIT family signature motif; other site 419947003459 catalytic residue [active] 419947003460 amidase; Provisional; Region: PRK12470 419947003461 Amidase; Region: Amidase; pfam01425 419947003462 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 419947003463 cyclase homology domain; Region: CHD; cd07302 419947003464 nucleotidyl binding site; other site 419947003465 metal binding site [ion binding]; metal-binding site 419947003466 dimer interface [polypeptide binding]; other site 419947003467 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 419947003468 Catalytic domain of Protein Kinases; Region: PKc; cd00180 419947003469 active site 419947003470 ATP binding site [chemical binding]; other site 419947003471 substrate binding site [chemical binding]; other site 419947003472 activation loop (A-loop); other site 419947003473 PknH-like extracellular domain; Region: PknH_C; pfam14032 419947003474 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 419947003475 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 419947003476 DNA binding site [nucleotide binding] 419947003477 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 419947003478 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 419947003479 phosphopeptide binding site; other site 419947003480 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 419947003481 putative active site [active] 419947003482 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 419947003483 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 419947003484 Protein of unknown function (DUF732); Region: DUF732; pfam05305 419947003485 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 419947003486 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 419947003487 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 419947003488 Walker A/P-loop; other site 419947003489 ATP binding site [chemical binding]; other site 419947003490 Q-loop/lid; other site 419947003491 ABC transporter signature motif; other site 419947003492 Walker B; other site 419947003493 D-loop; other site 419947003494 H-loop/switch region; other site 419947003495 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 419947003496 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 419947003497 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 419947003498 Walker A/P-loop; other site 419947003499 ATP binding site [chemical binding]; other site 419947003500 Q-loop/lid; other site 419947003501 ABC transporter signature motif; other site 419947003502 Walker B; other site 419947003503 D-loop; other site 419947003504 H-loop/switch region; other site 419947003505 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 419947003506 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 419947003507 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 419947003508 catalytic core [active] 419947003509 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 419947003510 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 419947003511 active site 419947003512 metal binding site [ion binding]; metal-binding site 419947003513 DNA binding site [nucleotide binding] 419947003514 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 419947003515 Walker A/P-loop; other site 419947003516 ATP binding site [chemical binding]; other site 419947003517 choline dehydrogenase; Validated; Region: PRK02106 419947003518 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 419947003519 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 419947003520 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 419947003521 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 419947003522 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 419947003523 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 419947003524 Walker A/P-loop; other site 419947003525 ATP binding site [chemical binding]; other site 419947003526 Q-loop/lid; other site 419947003527 ABC transporter signature motif; other site 419947003528 Walker B; other site 419947003529 D-loop; other site 419947003530 H-loop/switch region; other site 419947003531 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 419947003532 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 419947003533 Walker A/P-loop; other site 419947003534 ATP binding site [chemical binding]; other site 419947003535 Q-loop/lid; other site 419947003536 ABC transporter signature motif; other site 419947003537 Walker B; other site 419947003538 D-loop; other site 419947003539 H-loop/switch region; other site 419947003540 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 419947003541 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 419947003542 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 419947003543 dimer interface [polypeptide binding]; other site 419947003544 conserved gate region; other site 419947003545 putative PBP binding loops; other site 419947003546 ABC-ATPase subunit interface; other site 419947003547 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 419947003548 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 419947003549 dimer interface [polypeptide binding]; other site 419947003550 conserved gate region; other site 419947003551 putative PBP binding loops; other site 419947003552 ABC-ATPase subunit interface; other site 419947003553 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 419947003554 active site clefts [active] 419947003555 zinc binding site [ion binding]; other site 419947003556 dimer interface [polypeptide binding]; other site 419947003557 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 419947003558 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 419947003559 Active Sites [active] 419947003560 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 419947003561 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 419947003562 CysD dimerization site [polypeptide binding]; other site 419947003563 G1 box; other site 419947003564 putative GEF interaction site [polypeptide binding]; other site 419947003565 GTP/Mg2+ binding site [chemical binding]; other site 419947003566 Switch I region; other site 419947003567 G2 box; other site 419947003568 G3 box; other site 419947003569 Switch II region; other site 419947003570 G4 box; other site 419947003571 G5 box; other site 419947003572 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 419947003573 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 419947003574 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 419947003575 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 419947003576 Walker A/P-loop; other site 419947003577 ligand-binding site [chemical binding]; other site 419947003578 ATP binding site [chemical binding]; other site 419947003579 Rrf2 family protein; Region: rrf2_super; TIGR00738 419947003580 Transcriptional regulator; Region: Rrf2; pfam02082 419947003581 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 419947003582 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 419947003583 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 419947003584 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 419947003585 Putative esterase; Region: Esterase; pfam00756 419947003586 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 419947003587 Predicted membrane protein [Function unknown]; Region: COG4325 419947003588 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 419947003589 Protein of unknown function (DUF732); Region: DUF732; pfam05305 419947003590 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 419947003591 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 419947003592 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 419947003593 active site 419947003594 HIGH motif; other site 419947003595 KMSK motif region; other site 419947003596 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 419947003597 tRNA binding surface [nucleotide binding]; other site 419947003598 anticodon binding site; other site 419947003599 diaminopimelate decarboxylase; Region: lysA; TIGR01048 419947003600 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 419947003601 active site 419947003602 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 419947003603 substrate binding site [chemical binding]; other site 419947003604 catalytic residues [active] 419947003605 dimer interface [polypeptide binding]; other site 419947003606 homoserine dehydrogenase; Provisional; Region: PRK06349 419947003607 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 419947003608 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 419947003609 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 419947003610 threonine synthase; Reviewed; Region: PRK06721 419947003611 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 419947003612 homodimer interface [polypeptide binding]; other site 419947003613 pyridoxal 5'-phosphate binding site [chemical binding]; other site 419947003614 catalytic residue [active] 419947003615 Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083 419947003616 transcription termination factor Rho; Provisional; Region: PRK12678 419947003617 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 419947003618 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 419947003619 RNA binding site [nucleotide binding]; other site 419947003620 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 419947003621 multimer interface [polypeptide binding]; other site 419947003622 Walker A motif; other site 419947003623 ATP binding site [chemical binding]; other site 419947003624 Walker B motif; other site 419947003625 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 419947003626 peptide chain release factor 1; Region: prfA; TIGR00019 419947003627 This domain is found in peptide chain release factors; Region: PCRF; smart00937 419947003628 RF-1 domain; Region: RF-1; pfam00472 419947003629 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 419947003630 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 419947003631 S-adenosylmethionine binding site [chemical binding]; other site 419947003632 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 419947003633 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 419947003634 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 419947003635 Mg++ binding site [ion binding]; other site 419947003636 putative catalytic motif [active] 419947003637 substrate binding site [chemical binding]; other site 419947003638 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 419947003639 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 419947003640 F0F1 ATP synthase subunit C; Validated; Region: PRK05880 419947003641 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 419947003642 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 419947003643 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13428 419947003644 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 419947003645 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 419947003646 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 419947003647 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 419947003648 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 419947003649 Walker A motif; other site 419947003650 ATP binding site [chemical binding]; other site 419947003651 Walker B motif; other site 419947003652 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 419947003653 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 419947003654 core domain interface [polypeptide binding]; other site 419947003655 delta subunit interface [polypeptide binding]; other site 419947003656 epsilon subunit interface [polypeptide binding]; other site 419947003657 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 419947003658 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 419947003659 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 419947003660 alpha subunit interaction interface [polypeptide binding]; other site 419947003661 Walker A motif; other site 419947003662 ATP binding site [chemical binding]; other site 419947003663 Walker B motif; other site 419947003664 inhibitor binding site; inhibition site 419947003665 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 419947003666 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 419947003667 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 419947003668 gamma subunit interface [polypeptide binding]; other site 419947003669 epsilon subunit interface [polypeptide binding]; other site 419947003670 LBP interface [polypeptide binding]; other site 419947003671 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 419947003672 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 419947003673 Transposase; Region: DDE_Tnp_ISL3; pfam01610 419947003674 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 419947003675 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 419947003676 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 419947003677 hinge; other site 419947003678 active site 419947003679 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 419947003680 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 419947003681 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 419947003682 DNA binding site [nucleotide binding] 419947003683 active site 419947003684 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 419947003685 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 419947003686 AlkA N-terminal domain; Region: AlkA_N; pfam06029 419947003687 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 419947003688 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 419947003689 minor groove reading motif; other site 419947003690 helix-hairpin-helix signature motif; other site 419947003691 substrate binding pocket [chemical binding]; other site 419947003692 active site 419947003693 HAMP domain; Region: HAMP; pfam00672 419947003694 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 419947003695 cyclase homology domain; Region: CHD; cd07302 419947003696 nucleotidyl binding site; other site 419947003697 metal binding site [ion binding]; metal-binding site 419947003698 dimer interface [polypeptide binding]; other site 419947003699 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 419947003700 dimerization interface [polypeptide binding]; other site 419947003701 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 419947003702 cyclase homology domain; Region: CHD; cd07302 419947003703 nucleotidyl binding site; other site 419947003704 metal binding site [ion binding]; metal-binding site 419947003705 dimer interface [polypeptide binding]; other site 419947003706 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 419947003707 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 419947003708 dimerization interface [polypeptide binding]; other site 419947003709 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 419947003710 cyclase homology domain; Region: CHD; cd07302 419947003711 nucleotidyl binding site; other site 419947003712 metal binding site [ion binding]; metal-binding site 419947003713 dimer interface [polypeptide binding]; other site 419947003714 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 419947003715 hypothetical protein; Provisional; Region: PRK03298 419947003716 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 419947003717 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 419947003718 dimer interface [polypeptide binding]; other site 419947003719 substrate binding site [chemical binding]; other site 419947003720 metal binding site [ion binding]; metal-binding site 419947003721 putative acyltransferase; Provisional; Region: PRK05790 419947003722 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 419947003723 dimer interface [polypeptide binding]; other site 419947003724 active site 419947003725 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 419947003726 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 419947003727 PE family; Region: PE; pfam00934 419947003728 glycogen branching enzyme; Provisional; Region: PRK05402 419947003729 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 419947003730 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 419947003731 active site 419947003732 catalytic site [active] 419947003733 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 419947003734 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 419947003735 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 419947003736 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 419947003737 active site 419947003738 homodimer interface [polypeptide binding]; other site 419947003739 catalytic site [active] 419947003740 acceptor binding site [chemical binding]; other site 419947003741 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 419947003742 putative homodimer interface [polypeptide binding]; other site 419947003743 putative active site pocket [active] 419947003744 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 419947003745 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 419947003746 DEAD/DEAH box helicase; Region: DEAD; pfam00270 419947003747 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 419947003748 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 419947003749 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 419947003750 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 419947003751 active site 419947003752 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 419947003753 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 419947003754 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 419947003755 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 419947003756 putative active site pocket [active] 419947003757 cleavage site 419947003758 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 419947003759 MPN+ (JAMM) motif; other site 419947003760 Zinc-binding site [ion binding]; other site 419947003761 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 419947003762 MoaE interaction surface [polypeptide binding]; other site 419947003763 MoeB interaction surface [polypeptide binding]; other site 419947003764 thiocarboxylated glycine; other site 419947003765 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 419947003766 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 419947003767 dimer interface [polypeptide binding]; other site 419947003768 pyridoxal 5'-phosphate binding site [chemical binding]; other site 419947003769 catalytic residue [active] 419947003770 Rhomboid family; Region: Rhomboid; pfam01694 419947003771 glutamate racemase; Provisional; Region: PRK00865 419947003772 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 419947003773 ribonuclease PH; Reviewed; Region: rph; PRK00173 419947003774 Ribonuclease PH; Region: RNase_PH_bact; cd11362 419947003775 hexamer interface [polypeptide binding]; other site 419947003776 active site 419947003777 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 419947003778 active site 419947003779 dimerization interface [polypeptide binding]; other site 419947003780 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 419947003781 Glucitol operon activator [Transcription]; Region: GutM; COG4578 419947003782 acyl carrier protein; Validated; Region: PRK05883 419947003783 long-chain-fatty-acid--[acyl-carrier-protein] ligase; Validated; Region: PRK05851 419947003784 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 419947003785 acyl-activating enzyme (AAE) consensus motif; other site 419947003786 active site 419947003787 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 419947003788 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 419947003789 active site 419947003790 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 419947003791 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 419947003792 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 419947003793 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 419947003794 FAD binding pocket [chemical binding]; other site 419947003795 FAD binding motif [chemical binding]; other site 419947003796 phosphate binding motif [ion binding]; other site 419947003797 NAD binding pocket [chemical binding]; other site 419947003798 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 419947003799 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 419947003800 Walker A/P-loop; other site 419947003801 ATP binding site [chemical binding]; other site 419947003802 Q-loop/lid; other site 419947003803 ABC transporter signature motif; other site 419947003804 Walker B; other site 419947003805 D-loop; other site 419947003806 H-loop/switch region; other site 419947003807 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 419947003808 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 419947003809 Walker A/P-loop; other site 419947003810 ATP binding site [chemical binding]; other site 419947003811 Q-loop/lid; other site 419947003812 ABC transporter signature motif; other site 419947003813 Walker B; other site 419947003814 D-loop; other site 419947003815 H-loop/switch region; other site 419947003816 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 419947003817 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 419947003818 NAD(P) binding site [chemical binding]; other site 419947003819 active site 419947003820 tetracycline repressor protein TetR; Provisional; Region: PRK13756 419947003821 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 419947003822 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 419947003823 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 419947003824 GAF domain; Region: GAF; pfam01590 419947003825 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 419947003826 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 419947003827 metal binding site [ion binding]; metal-binding site 419947003828 active site 419947003829 I-site; other site 419947003830 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 419947003831 hypothetical protein; Provisional; Region: PRK07877 419947003832 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 419947003833 ATP binding site [chemical binding]; other site 419947003834 substrate interface [chemical binding]; other site 419947003835 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 419947003836 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 419947003837 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 419947003838 cyclase homology domain; Region: CHD; cd07302 419947003839 nucleotidyl binding site; other site 419947003840 dimer interface [polypeptide binding]; other site 419947003841 metal binding site [ion binding]; metal-binding site 419947003842 AAA ATPase domain; Region: AAA_16; pfam13191 419947003843 Predicted ATPase [General function prediction only]; Region: COG3903 419947003844 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 419947003845 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 419947003846 DNA binding residues [nucleotide binding] 419947003847 dimerization interface [polypeptide binding]; other site 419947003848 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 419947003849 cyclase homology domain; Region: CHD; cd07302 419947003850 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 419947003851 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 419947003852 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947003853 PPE family; Region: PPE; pfam00823 419947003854 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 419947003855 PAS fold; Region: PAS_4; pfam08448 419947003856 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 419947003857 putative active site [active] 419947003858 heme pocket [chemical binding]; other site 419947003859 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 419947003860 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 419947003861 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 419947003862 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 419947003863 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 419947003864 anti sigma factor interaction site; other site 419947003865 regulatory phosphorylation site [posttranslational modification]; other site 419947003866 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 419947003867 anti sigma factor interaction site; other site 419947003868 regulatory phosphorylation site [posttranslational modification]; other site 419947003869 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 419947003870 synthetase active site [active] 419947003871 NTP binding site [chemical binding]; other site 419947003872 metal binding site [ion binding]; metal-binding site 419947003873 Beta-lactamase; Region: Beta-lactamase; pfam00144 419947003874 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 419947003875 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 419947003876 putative transposase OrfB; Reviewed; Region: PHA02517 419947003877 HTH-like domain; Region: HTH_21; pfam13276 419947003878 Integrase core domain; Region: rve; pfam00665 419947003879 Integrase core domain; Region: rve_3; pfam13683 419947003880 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 419947003881 Transposase; Region: HTH_Tnp_1; cl17663 419947003882 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; pfam00173 419947003883 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 419947003884 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 419947003885 putative di-iron ligands [ion binding]; other site 419947003886 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 419947003887 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 419947003888 malonyl-CoA binding site [chemical binding]; other site 419947003889 dimer interface [polypeptide binding]; other site 419947003890 active site 419947003891 product binding site; other site 419947003892 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 419947003893 uncharacterized domain; Region: TIGR00702 419947003894 YcaO-like family; Region: YcaO; pfam02624 419947003895 Uncharacterized conserved protein [Function unknown]; Region: COG3482 419947003896 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 419947003897 S-adenosylmethionine binding site [chemical binding]; other site 419947003898 Domain of unknown function (DUF222); Region: DUF222; pfam02720 419947003899 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 419947003900 active site 419947003901 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 419947003902 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 419947003903 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 419947003904 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 419947003905 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 419947003906 dihydroorotase; Validated; Region: pyrC; PRK09357 419947003907 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 419947003908 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 419947003909 active site 419947003910 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 419947003911 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 419947003912 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 419947003913 catalytic site [active] 419947003914 subunit interface [polypeptide binding]; other site 419947003915 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 419947003916 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 419947003917 ATP-grasp domain; Region: ATP-grasp_4; cl17255 419947003918 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 419947003919 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 419947003920 ATP-grasp domain; Region: ATP-grasp_4; cl17255 419947003921 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 419947003922 IMP binding site; other site 419947003923 dimer interface [polypeptide binding]; other site 419947003924 interdomain contacts; other site 419947003925 partial ornithine binding site; other site 419947003926 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 419947003927 active site 419947003928 dimer interface [polypeptide binding]; other site 419947003929 PE family; Region: PE; pfam00934 419947003930 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947003931 PPE family; Region: PPE; pfam00823 419947003932 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 419947003933 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 419947003934 catalytic site [active] 419947003935 G-X2-G-X-G-K; other site 419947003936 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 419947003937 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 419947003938 Flavoprotein; Region: Flavoprotein; pfam02441 419947003939 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 419947003940 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 419947003941 S-adenosylmethionine synthetase; Validated; Region: PRK05250 419947003942 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 419947003943 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 419947003944 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 419947003945 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 419947003946 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 419947003947 Cytochrome P450; Region: p450; cl12078 419947003948 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 419947003949 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 419947003950 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 419947003951 PE family; Region: PE; pfam00934 419947003952 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 419947003953 oligomeric interface; other site 419947003954 putative active site [active] 419947003955 homodimer interface [polypeptide binding]; other site 419947003956 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 419947003957 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 419947003958 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 419947003959 substrate binding pocket [chemical binding]; other site 419947003960 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 419947003961 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 419947003962 substrate binding pocket [chemical binding]; other site 419947003963 Predicted membrane protein [Function unknown]; Region: COG3714 419947003964 primosome assembly protein PriA; Provisional; Region: PRK14873 419947003965 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 419947003966 S-adenosylmethionine binding site [chemical binding]; other site 419947003967 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 419947003968 MarR family; Region: MarR; pfam01047 419947003969 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 419947003970 S-adenosylmethionine binding site [chemical binding]; other site 419947003971 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 419947003972 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 419947003973 putative active site [active] 419947003974 substrate binding site [chemical binding]; other site 419947003975 putative cosubstrate binding site; other site 419947003976 catalytic site [active] 419947003977 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 419947003978 substrate binding site [chemical binding]; other site 419947003979 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 419947003980 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 419947003981 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 419947003982 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 419947003983 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 419947003984 substrate binding site [chemical binding]; other site 419947003985 hexamer interface [polypeptide binding]; other site 419947003986 metal binding site [ion binding]; metal-binding site 419947003987 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 419947003988 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 419947003989 catalytic motif [active] 419947003990 Zn binding site [ion binding]; other site 419947003991 RibD C-terminal domain; Region: RibD_C; pfam01872 419947003992 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 419947003993 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 419947003994 putative substrate translocation pore; other site 419947003995 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 419947003996 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 419947003997 Lumazine binding domain; Region: Lum_binding; pfam00677 419947003998 Lumazine binding domain; Region: Lum_binding; pfam00677 419947003999 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 419947004000 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 419947004001 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 419947004002 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 419947004003 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 419947004004 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 419947004005 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 419947004006 dimerization interface [polypeptide binding]; other site 419947004007 active site 419947004008 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 419947004009 homopentamer interface [polypeptide binding]; other site 419947004010 active site 419947004011 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 419947004012 PknH-like extracellular domain; Region: PknH_C; pfam14032 419947004013 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 419947004014 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 419947004015 putative sugar binding sites [chemical binding]; other site 419947004016 Q-X-W motif; other site 419947004017 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 419947004018 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 419947004019 GIY-YIG motif/motif A; other site 419947004020 active site 419947004021 catalytic site [active] 419947004022 putative DNA binding site [nucleotide binding]; other site 419947004023 metal binding site [ion binding]; metal-binding site 419947004024 UvrB/uvrC motif; Region: UVR; pfam02151 419947004025 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 419947004026 Helix-hairpin-helix motif; Region: HHH; pfam00633 419947004027 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 419947004028 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 419947004029 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 419947004030 phosphate binding site [ion binding]; other site 419947004031 putative substrate binding pocket [chemical binding]; other site 419947004032 dimer interface [polypeptide binding]; other site 419947004033 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 419947004034 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 419947004035 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 419947004036 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 419947004037 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 419947004038 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 419947004039 acyl-CoA synthetase; Provisional; Region: PRK13382 419947004040 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 419947004041 acyl-activating enzyme (AAE) consensus motif; other site 419947004042 putative AMP binding site [chemical binding]; other site 419947004043 putative active site [active] 419947004044 putative CoA binding site [chemical binding]; other site 419947004045 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 419947004046 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 419947004047 putative acyl-acceptor binding pocket; other site 419947004048 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 419947004049 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 419947004050 PE family; Region: PE; pfam00934 419947004051 PE-PPE domain; Region: PE-PPE; pfam08237 419947004052 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 419947004053 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 419947004054 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 419947004055 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 419947004056 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 419947004057 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 419947004058 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 419947004059 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 419947004060 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 419947004061 Phosphoglycerate kinase; Region: PGK; pfam00162 419947004062 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 419947004063 substrate binding site [chemical binding]; other site 419947004064 hinge regions; other site 419947004065 ADP binding site [chemical binding]; other site 419947004066 catalytic site [active] 419947004067 triosephosphate isomerase; Provisional; Region: PRK14567 419947004068 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 419947004069 substrate binding site [chemical binding]; other site 419947004070 dimer interface [polypeptide binding]; other site 419947004071 catalytic triad [active] 419947004072 SnoaL-like domain; Region: SnoaL_2; pfam12680 419947004073 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 419947004074 PE family; Region: PE; pfam00934 419947004075 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 419947004076 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 419947004077 molybdopterin cofactor binding site [chemical binding]; other site 419947004078 substrate binding site [chemical binding]; other site 419947004079 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 419947004080 molybdopterin cofactor binding site; other site 419947004081 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 419947004082 hydrophobic ligand binding site; other site 419947004083 Proteins of 100 residues with WXG; Region: WXG100; cl02005 419947004084 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 419947004085 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 419947004086 putative active site [active] 419947004087 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 419947004088 Glucose-6-P dehydrogenase subunit [Carbohydrate transport and metabolism]; Region: COG3429 419947004089 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 419947004090 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 419947004091 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 419947004092 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 419947004093 putative active site [active] 419947004094 transaldolase; Provisional; Region: PRK03903 419947004095 catalytic residue [active] 419947004096 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 419947004097 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 419947004098 TPP-binding site [chemical binding]; other site 419947004099 dimer interface [polypeptide binding]; other site 419947004100 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 419947004101 PYR/PP interface [polypeptide binding]; other site 419947004102 dimer interface [polypeptide binding]; other site 419947004103 TPP binding site [chemical binding]; other site 419947004104 PE family; Region: PE; pfam00934 419947004105 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 419947004106 UbiA prenyltransferase family; Region: UbiA; pfam01040 419947004107 PE family; Region: PE; pfam00934 419947004108 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 419947004109 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 419947004110 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 419947004111 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 419947004112 NADP binding site [chemical binding]; other site 419947004113 dimer interface [polypeptide binding]; other site 419947004114 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 419947004115 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 419947004116 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 419947004117 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 419947004118 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 419947004119 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 419947004120 Walker A/P-loop; other site 419947004121 ATP binding site [chemical binding]; other site 419947004122 Q-loop/lid; other site 419947004123 ABC transporter signature motif; other site 419947004124 Walker B; other site 419947004125 D-loop; other site 419947004126 H-loop/switch region; other site 419947004127 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 419947004128 Predicted transcriptional regulator [Transcription]; Region: COG2345 419947004129 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 419947004130 putative DNA binding site [nucleotide binding]; other site 419947004131 putative Zn2+ binding site [ion binding]; other site 419947004132 Transcriptional regulator PadR-like family; Region: PadR; cl17335 419947004133 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 419947004134 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 419947004135 protein-splicing catalytic site; other site 419947004136 thioester formation/cholesterol transfer; other site 419947004137 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 419947004138 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 419947004139 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 419947004140 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 419947004141 FeS assembly protein SufD; Region: sufD; TIGR01981 419947004142 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 419947004143 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 419947004144 Walker A/P-loop; other site 419947004145 ATP binding site [chemical binding]; other site 419947004146 Q-loop/lid; other site 419947004147 ABC transporter signature motif; other site 419947004148 Walker B; other site 419947004149 D-loop; other site 419947004150 H-loop/switch region; other site 419947004151 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 419947004152 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 419947004153 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 419947004154 catalytic residue [active] 419947004155 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 419947004156 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 419947004157 trimerization site [polypeptide binding]; other site 419947004158 active site 419947004159 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 419947004160 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 419947004161 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 419947004162 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 419947004163 active site 419947004164 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 419947004165 PE family; Region: PE; pfam00934 419947004166 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 419947004167 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 419947004168 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 419947004169 catalytic residues [active] 419947004170 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 419947004171 catalytic residues [active] 419947004172 enoyl-CoA hydratase; Provisional; Region: PRK05864 419947004173 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 419947004174 substrate binding site [chemical binding]; other site 419947004175 oxyanion hole (OAH) forming residues; other site 419947004176 trimer interface [polypeptide binding]; other site 419947004177 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 419947004178 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 419947004179 Walker A/P-loop; other site 419947004180 ATP binding site [chemical binding]; other site 419947004181 Q-loop/lid; other site 419947004182 ABC transporter signature motif; other site 419947004183 Walker B; other site 419947004184 D-loop; other site 419947004185 H-loop/switch region; other site 419947004186 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 419947004187 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 419947004188 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 419947004189 aconitate hydratase; Validated; Region: PRK09277 419947004190 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 419947004191 substrate binding site [chemical binding]; other site 419947004192 ligand binding site [chemical binding]; other site 419947004193 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 419947004194 substrate binding site [chemical binding]; other site 419947004195 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 419947004196 NlpC/P60 family; Region: NLPC_P60; pfam00877 419947004197 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 419947004198 NlpC/P60 family; Region: NLPC_P60; pfam00877 419947004199 MoxR-like ATPases [General function prediction only]; Region: COG0714 419947004200 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 419947004201 Walker A motif; other site 419947004202 ATP binding site [chemical binding]; other site 419947004203 Walker B motif; other site 419947004204 arginine finger; other site 419947004205 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 419947004206 Protein of unknown function DUF58; Region: DUF58; pfam01882 419947004207 hypothetical protein; Provisional; Region: PRK13685 419947004208 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 419947004209 metal ion-dependent adhesion site (MIDAS); other site 419947004210 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 419947004211 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 419947004212 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 419947004213 NAD(P) binding site [chemical binding]; other site 419947004214 homotetramer interface [polypeptide binding]; other site 419947004215 homodimer interface [polypeptide binding]; other site 419947004216 active site 419947004217 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 419947004218 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 419947004219 NAD binding site [chemical binding]; other site 419947004220 homotetramer interface [polypeptide binding]; other site 419947004221 homodimer interface [polypeptide binding]; other site 419947004222 substrate binding site [chemical binding]; other site 419947004223 active site 419947004224 ferrochelatase; Reviewed; Region: hemH; PRK00035 419947004225 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 419947004226 C-terminal domain interface [polypeptide binding]; other site 419947004227 active site 419947004228 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 419947004229 active site 419947004230 N-terminal domain interface [polypeptide binding]; other site 419947004231 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 419947004232 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 419947004233 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 419947004234 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 419947004235 Uncharacterized conserved protein [Function unknown]; Region: COG0398 419947004236 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 419947004237 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 419947004238 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 419947004239 heterodimer interface [polypeptide binding]; other site 419947004240 substrate interaction site [chemical binding]; other site 419947004241 Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding) [Lipid metabolism]; Region: Sbm; COG2185 419947004242 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 419947004243 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 419947004244 active site 419947004245 substrate binding site [chemical binding]; other site 419947004246 coenzyme B12 binding site [chemical binding]; other site 419947004247 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 419947004248 B12 binding site [chemical binding]; other site 419947004249 cobalt ligand [ion binding]; other site 419947004250 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 419947004251 membrane ATPase/protein kinase; Provisional; Region: PRK09435 419947004252 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 419947004253 Walker A; other site 419947004254 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 419947004255 Beta-lactamase; Region: Beta-lactamase; pfam00144 419947004256 Methyltransferase domain; Region: Methyltransf_31; pfam13847 419947004257 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 419947004258 S-adenosylmethionine binding site [chemical binding]; other site 419947004259 Uncharacterized conserved protein [Function unknown]; Region: COG3360 419947004260 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 419947004261 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 419947004262 Ligand binding site; other site 419947004263 Putative Catalytic site; other site 419947004264 DXD motif; other site 419947004265 Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5285 419947004266 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 419947004267 active site 419947004268 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 419947004269 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 419947004270 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 419947004271 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 419947004272 inhibitor-cofactor binding pocket; inhibition site 419947004273 pyridoxal 5'-phosphate binding site [chemical binding]; other site 419947004274 catalytic residue [active] 419947004275 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 419947004276 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 419947004277 putative trimer interface [polypeptide binding]; other site 419947004278 putative CoA binding site [chemical binding]; other site 419947004279 Methyltransferase domain; Region: Methyltransf_12; pfam08242 419947004280 S-adenosylmethionine binding site [chemical binding]; other site 419947004281 WbqC-like protein family; Region: WbqC; pfam08889 419947004282 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 419947004283 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 419947004284 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 419947004285 Methyltransferase domain; Region: Methyltransf_23; pfam13489 419947004286 Methyltransferase domain; Region: Methyltransf_12; pfam08242 419947004287 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 419947004288 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 419947004289 NADP-binding site; other site 419947004290 homotetramer interface [polypeptide binding]; other site 419947004291 substrate binding site [chemical binding]; other site 419947004292 homodimer interface [polypeptide binding]; other site 419947004293 active site 419947004294 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 419947004295 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 419947004296 NADP binding site [chemical binding]; other site 419947004297 active site 419947004298 putative substrate binding site [chemical binding]; other site 419947004299 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 419947004300 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 419947004301 metal-binding site 419947004302 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 419947004303 S-adenosylmethionine binding site [chemical binding]; other site 419947004304 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 419947004305 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 419947004306 active site 419947004307 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 419947004308 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 419947004309 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 419947004310 active site 419947004311 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 419947004312 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 419947004313 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 419947004314 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 419947004315 active site 419947004316 acyl-CoA synthetase; Validated; Region: PRK05850 419947004317 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 419947004318 acyl-activating enzyme (AAE) consensus motif; other site 419947004319 active site 419947004320 Transport protein; Region: actII; TIGR00833 419947004321 Methyltransferase domain; Region: Methyltransf_23; pfam13489 419947004322 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 419947004323 S-adenosylmethionine binding site [chemical binding]; other site 419947004324 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 419947004325 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 419947004326 homodimer interface [polypeptide binding]; other site 419947004327 active site 419947004328 TDP-binding site; other site 419947004329 acceptor substrate-binding pocket; other site 419947004330 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 419947004331 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 419947004332 Probable Catalytic site; other site 419947004333 metal-binding site 419947004334 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 419947004335 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 419947004336 homodimer interface [polypeptide binding]; other site 419947004337 active site 419947004338 TDP-binding site; other site 419947004339 acceptor substrate-binding pocket; other site 419947004340 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 419947004341 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 419947004342 active site 419947004343 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 419947004344 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 419947004345 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 419947004346 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 419947004347 Enoylreductase; Region: PKS_ER; smart00829 419947004348 NAD(P) binding site [chemical binding]; other site 419947004349 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 419947004350 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 419947004351 putative NADP binding site [chemical binding]; other site 419947004352 active site 419947004353 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 419947004354 acyl-CoA synthetase; Validated; Region: PRK05850 419947004355 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 419947004356 acyl-activating enzyme (AAE) consensus motif; other site 419947004357 active site 419947004358 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 419947004359 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 419947004360 NAD(P) binding site [chemical binding]; other site 419947004361 Uncharacterized conserved protein [Function unknown]; Region: COG2128 419947004362 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 419947004363 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 419947004364 CoenzymeA binding site [chemical binding]; other site 419947004365 subunit interaction site [polypeptide binding]; other site 419947004366 PHB binding site; other site 419947004367 Nitronate monooxygenase; Region: NMO; pfam03060 419947004368 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 419947004369 FMN binding site [chemical binding]; other site 419947004370 substrate binding site [chemical binding]; other site 419947004371 putative catalytic residue [active] 419947004372 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 419947004373 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 419947004374 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 419947004375 HIGH motif; other site 419947004376 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 419947004377 active site 419947004378 KMSKS motif; other site 419947004379 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 419947004380 tRNA binding surface [nucleotide binding]; other site 419947004381 anticodon binding site; other site 419947004382 DNA polymerase IV; Provisional; Region: PRK03348 419947004383 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 419947004384 active site 419947004385 DNA binding site [nucleotide binding] 419947004386 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 419947004387 active site 419947004388 homodimer interface [polypeptide binding]; other site 419947004389 homotetramer interface [polypeptide binding]; other site 419947004390 lipoprotein signal peptidase; Provisional; Region: PRK14764 419947004391 lipoprotein signal peptidase; Provisional; Region: PRK14787 419947004392 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 419947004393 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 419947004394 active site 419947004395 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 419947004396 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 419947004397 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 419947004398 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 419947004399 apolar tunnel; other site 419947004400 heme binding site [chemical binding]; other site 419947004401 dimerization interface [polypeptide binding]; other site 419947004402 short chain dehydrogenase; Provisional; Region: PRK05866 419947004403 classical (c) SDRs; Region: SDR_c; cd05233 419947004404 NAD(P) binding site [chemical binding]; other site 419947004405 active site 419947004406 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 419947004407 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 419947004408 NAD(P) binding site [chemical binding]; other site 419947004409 active site 419947004410 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 419947004411 hydrophobic ligand binding site; other site 419947004412 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 419947004413 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 419947004414 active site 419947004415 PHP Thumb interface [polypeptide binding]; other site 419947004416 metal binding site [ion binding]; metal-binding site 419947004417 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 419947004418 generic binding surface II; other site 419947004419 generic binding surface I; other site 419947004420 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947004421 PPE family; Region: PPE; pfam00823 419947004422 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 419947004423 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 419947004424 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 419947004425 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 419947004426 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 419947004427 acyl-activating enzyme (AAE) consensus motif; other site 419947004428 putative AMP binding site [chemical binding]; other site 419947004429 putative active site [active] 419947004430 putative CoA binding site [chemical binding]; other site 419947004431 glycerol-3-phosphate acyltransferase; Reviewed; Region: PRK11915 419947004432 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 419947004433 putative acyl-acceptor binding pocket; other site 419947004434 fumarate reductase, flavoprotein subunit; Region: fum_red_Fp; TIGR01176 419947004435 L-aspartate oxidase; Provisional; Region: PRK06175 419947004436 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 419947004437 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 419947004438 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 419947004439 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 419947004440 D-subunit interface [polypeptide binding]; other site 419947004441 Iron-sulfur protein interface; other site 419947004442 proximal quinone binding site [chemical binding]; other site 419947004443 distal quinone binding site [chemical binding]; other site 419947004444 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 419947004445 Iron-sulfur protein interface; other site 419947004446 proximal quinone binding site [chemical binding]; other site 419947004447 C-subunit interface; other site 419947004448 distal quinone binding site; other site 419947004449 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 419947004450 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 419947004451 MMPL family; Region: MMPL; pfam03176 419947004452 Domain of unknown function (DUF385); Region: DUF385; pfam04075 419947004453 threonine dehydratase; Validated; Region: PRK08639 419947004454 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 419947004455 tetramer interface [polypeptide binding]; other site 419947004456 pyridoxal 5'-phosphate binding site [chemical binding]; other site 419947004457 catalytic residue [active] 419947004458 C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585 419947004459 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 419947004460 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 419947004461 putative active site [active] 419947004462 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 419947004463 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 419947004464 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 419947004465 catalytic site [active] 419947004466 active site 419947004467 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 419947004468 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 419947004469 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 419947004470 active site 419947004471 catalytic site [active] 419947004472 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 419947004473 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 419947004474 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 419947004475 active site 419947004476 catalytic site [active] 419947004477 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 419947004478 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 419947004479 NlpC/P60 family; Region: NLPC_P60; pfam00877 419947004480 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 419947004481 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 419947004482 inhibitor-cofactor binding pocket; inhibition site 419947004483 pyridoxal 5'-phosphate binding site [chemical binding]; other site 419947004484 catalytic residue [active] 419947004485 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 419947004486 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 419947004487 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 419947004488 catalytic residue [active] 419947004489 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 419947004490 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 419947004491 Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653 419947004492 Phage capsid family; Region: Phage_capsid; pfam05065 419947004493 Phage head maturation protease [General function prediction only]; Region: COG3740 419947004494 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: COG3747 419947004495 Phage associated DNA primase [General function prediction only]; Region: COG3378 419947004496 D5 N terminal like; Region: D5_N; smart00885 419947004497 Protein of unknown function (DUF2742); Region: DUF2742; pfam10888 419947004498 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 419947004499 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 419947004500 catalytic residues [active] 419947004501 catalytic nucleophile [active] 419947004502 Recombinase; Region: Recombinase; pfam07508 419947004503 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 419947004504 Domain of unknown function (DUF222); Region: DUF222; pfam02720 419947004505 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 419947004506 active site 419947004507 Domain of unknown function (DUF222); Region: DUF222; pfam02720 419947004508 biotin synthase; Validated; Region: PRK06256 419947004509 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 419947004510 FeS/SAM binding site; other site 419947004511 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 419947004512 Protein of unknown function (DUF2567); Region: DUF2567; pfam10821 419947004513 Secretory lipase; Region: LIP; pfam03583 419947004514 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 419947004515 nudix motif; other site 419947004516 quinolinate synthetase; Provisional; Region: PRK09375 419947004517 L-aspartate oxidase; Provisional; Region: PRK07804 419947004518 L-aspartate oxidase; Provisional; Region: PRK06175 419947004519 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 419947004520 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 419947004521 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 419947004522 dimerization interface [polypeptide binding]; other site 419947004523 active site 419947004524 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 419947004525 S-adenosylmethionine binding site [chemical binding]; other site 419947004526 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 419947004527 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 419947004528 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 419947004529 NAD binding site [chemical binding]; other site 419947004530 dimerization interface [polypeptide binding]; other site 419947004531 product binding site; other site 419947004532 substrate binding site [chemical binding]; other site 419947004533 zinc binding site [ion binding]; other site 419947004534 catalytic residues [active] 419947004535 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 419947004536 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 419947004537 pyridoxal 5'-phosphate binding site [chemical binding]; other site 419947004538 homodimer interface [polypeptide binding]; other site 419947004539 catalytic residue [active] 419947004540 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 419947004541 4-fold oligomerization interface [polypeptide binding]; other site 419947004542 putative active site pocket [active] 419947004543 metal binding residues [ion binding]; metal-binding site 419947004544 3-fold/trimer interface [polypeptide binding]; other site 419947004545 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 419947004546 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 419947004547 putative active site [active] 419947004548 oxyanion strand; other site 419947004549 catalytic triad [active] 419947004550 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 419947004551 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 419947004552 catalytic residues [active] 419947004553 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 419947004554 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 419947004555 active site 419947004556 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 419947004557 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 419947004558 substrate binding site [chemical binding]; other site 419947004559 glutamase interaction surface [polypeptide binding]; other site 419947004560 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 419947004561 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 419947004562 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 419947004563 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 419947004564 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 419947004565 catalytic triad [active] 419947004566 anthranilate synthase component I; Provisional; Region: PRK13571 419947004567 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 419947004568 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 419947004569 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 419947004570 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 419947004571 active site 419947004572 ribulose/triose binding site [chemical binding]; other site 419947004573 phosphate binding site [ion binding]; other site 419947004574 substrate (anthranilate) binding pocket [chemical binding]; other site 419947004575 product (indole) binding pocket [chemical binding]; other site 419947004576 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 419947004577 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 419947004578 pyridoxal 5'-phosphate binding site [chemical binding]; other site 419947004579 catalytic residue [active] 419947004580 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 419947004581 substrate binding site [chemical binding]; other site 419947004582 active site 419947004583 catalytic residues [active] 419947004584 heterodimer interface [polypeptide binding]; other site 419947004585 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108 419947004586 Prolipoprotein diacylglyceryltransferase [Cell envelope biogenesis, outer membrane]; Region: Lgt; COG0682 419947004587 TM2 domain; Region: TM2; pfam05154 419947004588 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 419947004589 pyruvate kinase; Provisional; Region: PRK06247 419947004590 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 419947004591 domain interfaces; other site 419947004592 active site 419947004593 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 419947004594 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 419947004595 active site 419947004596 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 419947004597 catalytic triad [active] 419947004598 dimer interface [polypeptide binding]; other site 419947004599 Uncharacterized conserved protein [Function unknown]; Region: COG2898 419947004600 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 419947004601 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 419947004602 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 419947004603 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 419947004604 Walker A/P-loop; other site 419947004605 Walker A/P-loop; other site 419947004606 ATP binding site [chemical binding]; other site 419947004607 ATP binding site [chemical binding]; other site 419947004608 Q-loop/lid; other site 419947004609 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 419947004610 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 419947004611 Walker A/P-loop; other site 419947004612 ATP binding site [chemical binding]; other site 419947004613 Q-loop/lid; other site 419947004614 ABC transporter signature motif; other site 419947004615 Walker B; other site 419947004616 D-loop; other site 419947004617 H-loop/switch region; other site 419947004618 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 419947004619 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 419947004620 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 419947004621 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 419947004622 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 419947004623 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 419947004624 cyclase homology domain; Region: CHD; cd07302 419947004625 nucleotidyl binding site; other site 419947004626 metal binding site [ion binding]; metal-binding site 419947004627 dimer interface [polypeptide binding]; other site 419947004628 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 419947004629 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 419947004630 active site 419947004631 phosphorylation site [posttranslational modification] 419947004632 intermolecular recognition site; other site 419947004633 dimerization interface [polypeptide binding]; other site 419947004634 ANTAR domain; Region: ANTAR; pfam03861 419947004635 lipid-transfer protein; Provisional; Region: PRK06059 419947004636 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 419947004637 active site 419947004638 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 419947004639 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 419947004640 DUF35 OB-fold domain; Region: DUF35; pfam01796 419947004641 DNA polymerase I; Provisional; Region: PRK05755 419947004642 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 419947004643 active site 419947004644 metal binding site 1 [ion binding]; metal-binding site 419947004645 putative 5' ssDNA interaction site; other site 419947004646 metal binding site 3; metal-binding site 419947004647 metal binding site 2 [ion binding]; metal-binding site 419947004648 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 419947004649 putative DNA binding site [nucleotide binding]; other site 419947004650 putative metal binding site [ion binding]; other site 419947004651 3'-5' exonuclease; Region: 35EXOc; smart00474 419947004652 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 419947004653 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 419947004654 active site 419947004655 DNA binding site [nucleotide binding] 419947004656 catalytic site [active] 419947004657 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 419947004658 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 419947004659 RNA binding site [nucleotide binding]; other site 419947004660 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 419947004661 RNA binding site [nucleotide binding]; other site 419947004662 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 419947004663 RNA binding site [nucleotide binding]; other site 419947004664 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 419947004665 RNA binding site [nucleotide binding]; other site 419947004666 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 419947004667 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 419947004668 CoA-binding site [chemical binding]; other site 419947004669 ATP-binding [chemical binding]; other site 419947004670 Uncharacterized conserved protein [Function unknown]; Region: GrpB; COG2320 419947004671 Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306 419947004672 excinuclease ABC subunit B; Provisional; Region: PRK05298 419947004673 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 419947004674 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 419947004675 nucleotide binding region [chemical binding]; other site 419947004676 ATP-binding site [chemical binding]; other site 419947004677 Ultra-violet resistance protein B; Region: UvrB; pfam12344 419947004678 UvrB/uvrC motif; Region: UVR; pfam02151 419947004679 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 419947004680 Major Facilitator Superfamily; Region: MFS_1; pfam07690 419947004681 putative substrate translocation pore; other site 419947004682 Predicted membrane protein [Function unknown]; Region: COG5305 419947004683 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 419947004684 Ligand Binding Site [chemical binding]; other site 419947004685 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 419947004686 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 419947004687 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 419947004688 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 419947004689 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 419947004690 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 419947004691 Predicted esterase [General function prediction only]; Region: COG0627 419947004692 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 419947004693 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 419947004694 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 419947004695 dimer interface [polypeptide binding]; other site 419947004696 putative anticodon binding site; other site 419947004697 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 419947004698 motif 1; other site 419947004699 dimer interface [polypeptide binding]; other site 419947004700 active site 419947004701 motif 2; other site 419947004702 motif 3; other site 419947004703 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 419947004704 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 419947004705 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 419947004706 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 419947004707 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 419947004708 23S rRNA binding site [nucleotide binding]; other site 419947004709 L21 binding site [polypeptide binding]; other site 419947004710 L13 binding site [polypeptide binding]; other site 419947004711 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 419947004712 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 419947004713 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 419947004714 PE family; Region: PE; pfam00934 419947004715 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 419947004716 cyclase homology domain; Region: CHD; cd07302 419947004717 nucleotidyl binding site; other site 419947004718 metal binding site [ion binding]; metal-binding site 419947004719 dimer interface [polypeptide binding]; other site 419947004720 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 419947004721 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 419947004722 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 419947004723 dimer interface [polypeptide binding]; other site 419947004724 motif 1; other site 419947004725 active site 419947004726 motif 2; other site 419947004727 motif 3; other site 419947004728 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 419947004729 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 419947004730 putative tRNA-binding site [nucleotide binding]; other site 419947004731 B3/4 domain; Region: B3_4; pfam03483 419947004732 tRNA synthetase B5 domain; Region: B5; smart00874 419947004733 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 419947004734 dimer interface [polypeptide binding]; other site 419947004735 motif 1; other site 419947004736 motif 3; other site 419947004737 motif 2; other site 419947004738 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 419947004739 PE family; Region: PE; pfam00934 419947004740 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 419947004741 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 419947004742 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 419947004743 heterotetramer interface [polypeptide binding]; other site 419947004744 active site pocket [active] 419947004745 cleavage site 419947004746 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 419947004747 feedback inhibition sensing region; other site 419947004748 homohexameric interface [polypeptide binding]; other site 419947004749 nucleotide binding site [chemical binding]; other site 419947004750 N-acetyl-L-glutamate binding site [chemical binding]; other site 419947004751 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 419947004752 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 419947004753 inhibitor-cofactor binding pocket; inhibition site 419947004754 pyridoxal 5'-phosphate binding site [chemical binding]; other site 419947004755 catalytic residue [active] 419947004756 ornithine carbamoyltransferase; Provisional; Region: PRK00779 419947004757 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 419947004758 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 419947004759 arginine repressor; Provisional; Region: PRK03341 419947004760 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 419947004761 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 419947004762 argininosuccinate synthase; Provisional; Region: PRK13820 419947004763 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 419947004764 ANP binding site [chemical binding]; other site 419947004765 Substrate Binding Site II [chemical binding]; other site 419947004766 Substrate Binding Site I [chemical binding]; other site 419947004767 argininosuccinate lyase; Provisional; Region: PRK00855 419947004768 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 419947004769 active sites [active] 419947004770 tetramer interface [polypeptide binding]; other site 419947004771 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 419947004772 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 419947004773 malonyl-CoA binding site [chemical binding]; other site 419947004774 dimer interface [polypeptide binding]; other site 419947004775 active site 419947004776 product binding site; other site 419947004777 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 419947004778 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 419947004779 active site 419947004780 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 419947004781 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 419947004782 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 419947004783 Enoylreductase; Region: PKS_ER; smart00829 419947004784 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 419947004785 NAD(P) binding site [chemical binding]; other site 419947004786 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 419947004787 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 419947004788 putative NADP binding site [chemical binding]; other site 419947004789 active site 419947004790 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 419947004791 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 419947004792 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 419947004793 active site 419947004794 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 419947004795 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 419947004796 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 419947004797 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 419947004798 Enoylreductase; Region: PKS_ER; smart00829 419947004799 NAD(P) binding site [chemical binding]; other site 419947004800 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 419947004801 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 419947004802 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 419947004803 putative NADP binding site [chemical binding]; other site 419947004804 active site 419947004805 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 419947004806 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 419947004807 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 419947004808 active site 419947004809 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 419947004810 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 419947004811 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 419947004812 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 419947004813 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 419947004814 malonyl-CoA binding site [chemical binding]; other site 419947004815 dimer interface [polypeptide binding]; other site 419947004816 active site 419947004817 product binding site; other site 419947004818 Cytochrome P450; Region: p450; cl12078 419947004819 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 419947004820 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 419947004821 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 419947004822 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 419947004823 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 419947004824 ABC transporter; Region: ABC_tran_2; pfam12848 419947004825 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 419947004826 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 419947004827 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 419947004828 putative substrate translocation pore; other site 419947004829 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 419947004830 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 419947004831 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 419947004832 dimerization interface [polypeptide binding]; other site 419947004833 putative DNA binding site [nucleotide binding]; other site 419947004834 putative Zn2+ binding site [ion binding]; other site 419947004835 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 419947004836 active site residue [active] 419947004837 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 419947004838 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 419947004839 ligand binding site [chemical binding]; other site 419947004840 flexible hinge region; other site 419947004841 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 419947004842 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 419947004843 putative catalytic residues [active] 419947004844 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 419947004845 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 419947004846 catalytic residues [active] 419947004847 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 419947004848 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 419947004849 active site 419947004850 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 419947004851 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 419947004852 substrate binding pocket [chemical binding]; other site 419947004853 membrane-bound complex binding site; other site 419947004854 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 419947004855 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 419947004856 FeS/SAM binding site; other site 419947004857 DivIVA protein; Region: DivIVA; pfam05103 419947004858 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 419947004859 acyl-CoA synthetase; Validated; Region: PRK07868 419947004860 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 419947004861 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 419947004862 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 419947004863 acyl-activating enzyme (AAE) consensus motif; other site 419947004864 AMP binding site [chemical binding]; other site 419947004865 active site 419947004866 CoA binding site [chemical binding]; other site 419947004867 Uncharacterized conserved protein [Function unknown]; Region: COG2835 419947004868 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 419947004869 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 419947004870 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 419947004871 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 419947004872 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 419947004873 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 419947004874 Walker A/P-loop; other site 419947004875 ATP binding site [chemical binding]; other site 419947004876 Q-loop/lid; other site 419947004877 ABC transporter signature motif; other site 419947004878 Walker B; other site 419947004879 D-loop; other site 419947004880 H-loop/switch region; other site 419947004881 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 419947004882 active site 419947004883 DNA binding site [nucleotide binding] 419947004884 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 419947004885 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 419947004886 active site 419947004887 HIGH motif; other site 419947004888 dimer interface [polypeptide binding]; other site 419947004889 KMSKS motif; other site 419947004890 S4 RNA-binding domain; Region: S4; smart00363 419947004891 RNA binding surface [nucleotide binding]; other site 419947004892 Protein of unknown function (DUF732); Region: DUF732; pfam05305 419947004893 Tetratrico peptide repeat; Region: TPR_5; pfam12688 419947004894 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 419947004895 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 419947004896 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 419947004897 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 419947004898 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 419947004899 RNA binding surface [nucleotide binding]; other site 419947004900 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 419947004901 S-adenosylmethionine binding site [chemical binding]; other site 419947004902 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 419947004903 ATP-NAD kinase; Region: NAD_kinase; pfam01513 419947004904 DNA repair protein RecN; Region: recN; TIGR00634 419947004905 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 419947004906 Walker A/P-loop; other site 419947004907 ATP binding site [chemical binding]; other site 419947004908 Q-loop/lid; other site 419947004909 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 419947004910 ABC transporter signature motif; other site 419947004911 Walker B; other site 419947004912 D-loop; other site 419947004913 H-loop/switch region; other site 419947004914 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 419947004915 Thiamine pyrophosphokinase; Region: TPK; cl08415 419947004916 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 419947004917 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 419947004918 CTP synthetase; Validated; Region: pyrG; PRK05380 419947004919 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 419947004920 Catalytic site [active] 419947004921 active site 419947004922 UTP binding site [chemical binding]; other site 419947004923 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 419947004924 active site 419947004925 putative oxyanion hole; other site 419947004926 catalytic triad [active] 419947004927 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 419947004928 dimer interface [polypeptide binding]; other site 419947004929 ADP-ribose binding site [chemical binding]; other site 419947004930 active site 419947004931 nudix motif; other site 419947004932 metal binding site [ion binding]; metal-binding site 419947004933 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 419947004934 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 419947004935 active site 419947004936 DNA binding site [nucleotide binding] 419947004937 Int/Topo IB signature motif; other site 419947004938 Domain of unknown function (DUF222); Region: DUF222; pfam02720 419947004939 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 419947004940 active site 419947004941 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 419947004942 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 419947004943 S-adenosylmethionine binding site [chemical binding]; other site 419947004944 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 419947004945 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947004946 PPE family; Region: PPE; pfam00823 419947004947 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 419947004948 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947004949 PPE family; Region: PPE; pfam00823 419947004950 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 419947004951 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 419947004952 Sulfate transporter family; Region: Sulfate_transp; pfam00916 419947004953 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 419947004954 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 419947004955 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 419947004956 P-loop; other site 419947004957 Magnesium ion binding site [ion binding]; other site 419947004958 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 419947004959 Magnesium ion binding site [ion binding]; other site 419947004960 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 419947004961 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 419947004962 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 419947004963 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 419947004964 RNA binding surface [nucleotide binding]; other site 419947004965 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 419947004966 active site 419947004967 cytidylate kinase; Provisional; Region: cmk; PRK00023 419947004968 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 419947004969 CMP-binding site; other site 419947004970 The sites determining sugar specificity; other site 419947004971 GTP-binding protein Der; Reviewed; Region: PRK03003 419947004972 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 419947004973 GTP/Mg2+ binding site [chemical binding]; other site 419947004974 Switch I region; other site 419947004975 G2 box; other site 419947004976 Switch II region; other site 419947004977 G3 box; other site 419947004978 G4 box; other site 419947004979 G5 box; other site 419947004980 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 419947004981 G1 box; other site 419947004982 GTP/Mg2+ binding site [chemical binding]; other site 419947004983 Switch I region; other site 419947004984 G2 box; other site 419947004985 G3 box; other site 419947004986 Switch II region; other site 419947004987 G4 box; other site 419947004988 G5 box; other site 419947004989 short chain dehydrogenase; Provisional; Region: PRK07060 419947004990 classical (c) SDRs; Region: SDR_c; cd05233 419947004991 NAD(P) binding site [chemical binding]; other site 419947004992 active site 419947004993 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 419947004994 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 419947004995 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 419947004996 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 419947004997 Cupin domain; Region: Cupin_2; pfam07883 419947004998 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 419947004999 Transcriptional regulator [Transcription]; Region: IclR; COG1414 419947005000 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 419947005001 putative switch regulator; other site 419947005002 non-specific DNA interactions [nucleotide binding]; other site 419947005003 DNA binding site [nucleotide binding] 419947005004 sequence specific DNA binding site [nucleotide binding]; other site 419947005005 putative cAMP binding site [chemical binding]; other site 419947005006 Bacterial transcriptional regulator; Region: IclR; pfam01614 419947005007 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 419947005008 putative active site [active] 419947005009 homotetrameric interface [polypeptide binding]; other site 419947005010 metal binding site [ion binding]; metal-binding site 419947005011 biotin carboxylase-like protein; Validated; Region: PRK06524 419947005012 ATP-grasp domain; Region: ATP-grasp_4; cl17255 419947005013 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 419947005014 Beta-lactamase; Region: Beta-lactamase; pfam00144 419947005015 Predicted transcriptional regulators [Transcription]; Region: COG1733 419947005016 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 419947005017 dimerization interface [polypeptide binding]; other site 419947005018 putative DNA binding site [nucleotide binding]; other site 419947005019 putative Zn2+ binding site [ion binding]; other site 419947005020 Predicted transcriptional regulators [Transcription]; Region: COG1733 419947005021 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 419947005022 FAD binding domain; Region: FAD_binding_4; pfam01565 419947005023 Berberine and berberine like; Region: BBE; pfam08031 419947005024 TIGR03086 family protein; Region: TIGR03086 419947005025 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 419947005026 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 419947005027 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 419947005028 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 419947005029 Beta-lactamase; Region: Beta-lactamase; pfam00144 419947005030 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 419947005031 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 419947005032 NAD(P) binding site [chemical binding]; other site 419947005033 catalytic residues [active] 419947005034 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 419947005035 putative catalytic residue [active] 419947005036 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 419947005037 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 419947005038 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 419947005039 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 419947005040 gating phenylalanine in ion channel; other site 419947005041 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 419947005042 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 419947005043 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 419947005044 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 419947005045 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 419947005046 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 419947005047 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 419947005048 putative substrate translocation pore; other site 419947005049 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 419947005050 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 419947005051 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 419947005052 Sulfate transporter family; Region: Sulfate_transp; pfam00916 419947005053 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 419947005054 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 419947005055 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3742 419947005056 putative active site [active] 419947005057 Protein tyrosine kinase; Region: Pkinase_Tyr; pfam07714 419947005058 Catalytic domain of Protein Kinases; Region: PKc; cd00180 419947005059 active site 419947005060 ATP binding site [chemical binding]; other site 419947005061 substrate binding site [chemical binding]; other site 419947005062 activation loop (A-loop); other site 419947005063 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 419947005064 Thioredoxin; Region: Thioredoxin_4; cl17273 419947005065 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 419947005066 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 419947005067 active site 419947005068 metal binding site [ion binding]; metal-binding site 419947005069 nudix motif; other site 419947005070 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 419947005071 Catalytic domain of Protein Kinases; Region: PKc; cd00180 419947005072 active site 419947005073 ATP binding site [chemical binding]; other site 419947005074 substrate binding site [chemical binding]; other site 419947005075 activation loop (A-loop); other site 419947005076 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 419947005077 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 419947005078 phosphopeptide binding site; other site 419947005079 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 419947005080 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 419947005081 phosphopeptide binding site; other site 419947005082 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 419947005083 The Eye Pigment Precursor Transporter (EPP) Family protein; Region: 3a01204; TIGR00955 419947005084 Walker A/P-loop; other site 419947005085 ATP binding site [chemical binding]; other site 419947005086 Q-loop/lid; other site 419947005087 ABC transporter signature motif; other site 419947005088 Walker B; other site 419947005089 D-loop; other site 419947005090 H-loop/switch region; other site 419947005091 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 419947005092 acyl-CoA synthetase; Provisional; Region: PRK13388 419947005093 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 419947005094 acyl-activating enzyme (AAE) consensus motif; other site 419947005095 AMP binding site [chemical binding]; other site 419947005096 active site 419947005097 CoA binding site [chemical binding]; other site 419947005098 hypothetical protein; Provisional; Region: PRK06185 419947005099 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 419947005100 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 419947005101 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 419947005102 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947005103 PPE family; Region: PPE; pfam00823 419947005104 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 419947005105 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 419947005106 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 419947005107 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 419947005108 Phosphoesterase family; Region: Phosphoesterase; pfam04185 419947005109 putative transposase OrfB; Reviewed; Region: PHA02517 419947005110 HTH-like domain; Region: HTH_21; pfam13276 419947005111 Integrase core domain; Region: rve; pfam00665 419947005112 Integrase core domain; Region: rve_3; pfam13683 419947005113 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 419947005114 Transposase; Region: HTH_Tnp_1; cl17663 419947005115 Phosphoesterase family; Region: Phosphoesterase; pfam04185 419947005116 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 419947005117 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 419947005118 sulfite oxidase; Provisional; Region: PLN00177 419947005119 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 419947005120 Moco binding site; other site 419947005121 metal coordination site [ion binding]; other site 419947005122 dimerization interface [polypeptide binding]; other site 419947005123 Transport protein; Region: actII; TIGR00833 419947005124 putative transposase OrfB; Reviewed; Region: PHA02517 419947005125 HTH-like domain; Region: HTH_21; pfam13276 419947005126 Integrase core domain; Region: rve; pfam00665 419947005127 Integrase core domain; Region: rve_3; pfam13683 419947005128 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 419947005129 Transposase; Region: HTH_Tnp_1; cl17663 419947005130 Cutinase; Region: Cutinase; pfam01083 419947005131 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 419947005132 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 419947005133 Uncharacterized conserved protein [Function unknown]; Region: COG0393 419947005134 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 419947005135 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 419947005136 Transposase; Region: HTH_Tnp_1; cl17663 419947005137 putative transposase OrfB; Reviewed; Region: PHA02517 419947005138 HTH-like domain; Region: HTH_21; pfam13276 419947005139 Integrase core domain; Region: rve; pfam00665 419947005140 Integrase core domain; Region: rve_3; pfam13683 419947005141 Integrase core domain; Region: rve_3; cl15866 419947005142 Domain of unknown function (DUF222); Region: DUF222; pfam02720 419947005143 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 419947005144 active site 419947005145 Integrase core domain; Region: rve; pfam00665 419947005146 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 419947005147 putative homotetramer interface [polypeptide binding]; other site 419947005148 putative homodimer interface [polypeptide binding]; other site 419947005149 putative allosteric switch controlling residues; other site 419947005150 putative metal binding site [ion binding]; other site 419947005151 putative homodimer-homodimer interface [polypeptide binding]; other site 419947005152 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 419947005153 PE family; Region: PE; pfam00934 419947005154 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 419947005155 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 419947005156 dimer interface [polypeptide binding]; other site 419947005157 active site 419947005158 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 419947005159 substrate binding site [chemical binding]; other site 419947005160 catalytic residue [active] 419947005161 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 419947005162 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 419947005163 metal binding site [ion binding]; metal-binding site 419947005164 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 419947005165 FAD binding domain; Region: FAD_binding_4; pfam01565 419947005166 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 419947005167 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 419947005168 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 419947005169 Transcriptional regulator [Transcription]; Region: IclR; COG1414 419947005170 Bacterial transcriptional regulator; Region: IclR; pfam01614 419947005171 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 419947005172 FAD binding domain; Region: FAD_binding_4; pfam01565 419947005173 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 419947005174 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 419947005175 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 419947005176 Cytochrome P450; Region: p450; cl12078 419947005177 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 419947005178 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 419947005179 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 419947005180 Protein of unknown function (DUF690); Region: DUF690; pfam05108 419947005181 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 419947005182 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 419947005183 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 419947005184 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 419947005185 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 419947005186 Cytochrome P450; Region: p450; cl12078 419947005187 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 419947005188 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947005189 PPE family; Region: PPE; pfam00823 419947005190 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 419947005191 PE family; Region: PE; pfam00934 419947005192 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947005193 PPE family; Region: PPE; pfam00823 419947005194 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 419947005195 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947005196 PPE family; Region: PPE; pfam00823 419947005197 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 419947005198 PE family; Region: PE; pfam00934 419947005199 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 419947005200 EspG family; Region: ESX-1_EspG; pfam14011 419947005201 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 419947005202 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 419947005203 catalytic residues [active] 419947005204 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 419947005205 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 419947005206 active site 419947005207 catalytic residues [active] 419947005208 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 419947005209 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 419947005210 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 419947005211 Walker A motif; other site 419947005212 ATP binding site [chemical binding]; other site 419947005213 Walker B motif; other site 419947005214 arginine finger; other site 419947005215 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947005216 PPE family; Region: PPE; pfam00823 419947005217 PE-PPE domain; Region: PE-PPE; pfam08237 419947005218 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947005219 PPE family; Region: PPE; pfam00823 419947005220 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947005221 PPE family; Region: PPE; pfam00823 419947005222 PE family; Region: PE; pfam00934 419947005223 Protein of unknown function (DUF732); Region: DUF732; pfam05305 419947005224 PE family; Region: PE; pfam00934 419947005225 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947005226 PPE family; Region: PPE; pfam00823 419947005227 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947005228 PPE family; Region: PPE; pfam00823 419947005229 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947005230 PPE family; Region: PPE; pfam00823 419947005231 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 419947005232 Protein of unknown function (DUF732); Region: DUF732; pfam05305 419947005233 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 419947005234 MgtC family; Region: MgtC; pfam02308 419947005235 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 419947005236 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 419947005237 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 419947005238 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 419947005239 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 419947005240 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 419947005241 hypothetical protein; Validated; Region: PRK07121 419947005242 PE family; Region: PE; pfam00934 419947005243 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 419947005244 ABC transporter transmembrane region 2; Region: ABC_membrane_2; pfam06472 419947005245 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 419947005246 hypothetical protein; Provisional; Region: PRK05858 419947005247 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 419947005248 PYR/PP interface [polypeptide binding]; other site 419947005249 dimer interface [polypeptide binding]; other site 419947005250 TPP binding site [chemical binding]; other site 419947005251 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 419947005252 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 419947005253 TPP-binding site; other site 419947005254 dimer interface [polypeptide binding]; other site 419947005255 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 419947005256 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 419947005257 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 419947005258 nucleotide binding region [chemical binding]; other site 419947005259 ATP-binding site [chemical binding]; other site 419947005260 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 419947005261 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 419947005262 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 419947005263 Uncharacterized conserved protein (small basic protein) [Function unknown]; Region: Sbp; COG3856 419947005264 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 419947005265 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 419947005266 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 419947005267 lipoyl attachment site [posttranslational modification]; other site 419947005268 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 419947005269 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 419947005270 phosphopeptide binding site; other site 419947005271 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 419947005272 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 419947005273 DNA binding residues [nucleotide binding] 419947005274 Bifunctional nuclease; Region: DNase-RNase; pfam02577 419947005275 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 419947005276 DNA binding residues [nucleotide binding] 419947005277 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 419947005278 putative dimer interface [polypeptide binding]; other site 419947005279 glycine dehydrogenase; Provisional; Region: PRK05367 419947005280 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 419947005281 pyridoxal 5'-phosphate binding site [chemical binding]; other site 419947005282 tetramer interface [polypeptide binding]; other site 419947005283 catalytic residue [active] 419947005284 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 419947005285 tetramer interface [polypeptide binding]; other site 419947005286 pyridoxal 5'-phosphate binding site [chemical binding]; other site 419947005287 catalytic residue [active] 419947005288 haloalkane dehalogenase; Provisional; Region: PRK03204 419947005289 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 419947005290 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 419947005291 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 419947005292 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 419947005293 metal ion-dependent adhesion site (MIDAS); other site 419947005294 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 419947005295 active site 419947005296 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 419947005297 putative active site [active] 419947005298 Domain of unknown function DUF21; Region: DUF21; pfam01595 419947005299 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 419947005300 FOG: CBS domain [General function prediction only]; Region: COG0517 419947005301 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 419947005302 Domain of unknown function DUF21; Region: DUF21; pfam01595 419947005303 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 419947005304 Transporter associated domain; Region: CorC_HlyC; smart01091 419947005305 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 419947005306 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 419947005307 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 419947005308 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 419947005309 active site 419947005310 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 419947005311 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 419947005312 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 419947005313 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 419947005314 Predicted transcriptional regulator [Transcription]; Region: COG3682 419947005315 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 419947005316 CoenzymeA binding site [chemical binding]; other site 419947005317 subunit interaction site [polypeptide binding]; other site 419947005318 PHB binding site; other site 419947005319 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 419947005320 alpha-gamma subunit interface [polypeptide binding]; other site 419947005321 beta-gamma subunit interface [polypeptide binding]; other site 419947005322 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 419947005323 gamma-beta subunit interface [polypeptide binding]; other site 419947005324 alpha-beta subunit interface [polypeptide binding]; other site 419947005325 urease subunit alpha; Reviewed; Region: ureC; PRK13206 419947005326 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 419947005327 subunit interactions [polypeptide binding]; other site 419947005328 active site 419947005329 flap region; other site 419947005330 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 419947005331 UreF; Region: UreF; pfam01730 419947005332 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 419947005333 UreD urease accessory protein; Region: UreD; cl00530 419947005334 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 419947005335 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 419947005336 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 419947005337 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 419947005338 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 419947005339 classical (c) SDRs; Region: SDR_c; cd05233 419947005340 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 419947005341 NAD(P) binding site [chemical binding]; other site 419947005342 active site 419947005343 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 419947005344 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 419947005345 sulfate transport protein; Provisional; Region: cysT; CHL00187 419947005346 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 419947005347 dimer interface [polypeptide binding]; other site 419947005348 conserved gate region; other site 419947005349 putative PBP binding loops; other site 419947005350 ABC-ATPase subunit interface; other site 419947005351 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 419947005352 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 419947005353 Walker A/P-loop; other site 419947005354 ATP binding site [chemical binding]; other site 419947005355 Q-loop/lid; other site 419947005356 ABC transporter signature motif; other site 419947005357 Walker B; other site 419947005358 D-loop; other site 419947005359 H-loop/switch region; other site 419947005360 TOBE domain; Region: TOBE; pfam03459 419947005361 Fibronectin-attachment protein (FAP); Region: FAP; pfam07174 419947005362 Predicted membrane protein [Function unknown]; Region: COG2261 419947005363 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 419947005364 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 419947005365 putative NAD(P) binding site [chemical binding]; other site 419947005366 putative substrate binding site [chemical binding]; other site 419947005367 catalytic Zn binding site [ion binding]; other site 419947005368 structural Zn binding site [ion binding]; other site 419947005369 CAAX protease self-immunity; Region: Abi; pfam02517 419947005370 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 419947005371 MOSC domain; Region: MOSC; pfam03473 419947005372 short chain dehydrogenase; Provisional; Region: PRK07825 419947005373 classical (c) SDRs; Region: SDR_c; cd05233 419947005374 NAD(P) binding site [chemical binding]; other site 419947005375 active site 419947005376 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 419947005377 CoA-transferase family III; Region: CoA_transf_3; pfam02515 419947005378 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 419947005379 CoA-transferase family III; Region: CoA_transf_3; pfam02515 419947005380 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 419947005381 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 419947005382 active site 419947005383 hypothetical protein; Provisional; Region: PRK12320 419947005384 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 419947005385 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 419947005386 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 419947005387 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 419947005388 Domain of unknown function (DUF385); Region: DUF385; pfam04075 419947005389 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 419947005390 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 419947005391 active site 419947005392 substrate binding site [chemical binding]; other site 419947005393 FMN binding site [chemical binding]; other site 419947005394 putative catalytic residues [active] 419947005395 Uncharacterized conserved protein [Function unknown]; Region: COG5579 419947005396 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 419947005397 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 419947005398 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 419947005399 heme binding site [chemical binding]; other site 419947005400 ferroxidase pore; other site 419947005401 ferroxidase diiron center [ion binding]; other site 419947005402 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 419947005403 Major Facilitator Superfamily; Region: MFS_1; pfam07690 419947005404 putative substrate translocation pore; other site 419947005405 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 419947005406 putative substrate translocation pore; other site 419947005407 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cl00333 419947005408 23S rRNA interface [nucleotide binding]; other site 419947005409 L3 interface [polypeptide binding]; other site 419947005410 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 419947005411 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 419947005412 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 419947005413 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 419947005414 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 419947005415 Cytochrome P450; Region: p450; cl12078 419947005416 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 419947005417 short chain dehydrogenase; Provisional; Region: PRK08267 419947005418 classical (c) SDR, subgroup 9; Region: SDR_c9; cd08931 419947005419 putative NAD(P) binding site [chemical binding]; other site 419947005420 active site 419947005421 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 419947005422 hydrophobic ligand binding site; other site 419947005423 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 419947005424 chorismate mutase; Provisional; Region: PRK09269 419947005425 chorismate mutase, putative; Region: CM_mono2; TIGR01806 419947005426 Putative esterase; Region: Esterase; pfam00756 419947005427 Leucine carboxyl methyltransferase; Region: LCM; cl01306 419947005428 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 419947005429 Leucine carboxyl methyltransferase; Region: LCM; cl01306 419947005430 Uncharacterized conserved protein [Function unknown]; Region: COG2353 419947005431 Nitronate monooxygenase; Region: NMO; pfam03060 419947005432 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 419947005433 FMN binding site [chemical binding]; other site 419947005434 substrate binding site [chemical binding]; other site 419947005435 putative catalytic residue [active] 419947005436 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 2; Region: FDH_like_2; cd08284 419947005437 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 419947005438 catalytic Zn binding site [ion binding]; other site 419947005439 NAD(P) binding site [chemical binding]; other site 419947005440 structural Zn binding site [ion binding]; other site 419947005441 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 419947005442 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 419947005443 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 419947005444 putative active site [active] 419947005445 dimerization interface [polypeptide binding]; other site 419947005446 putative tRNAtyr binding site [nucleotide binding]; other site 419947005447 Domain of unknown function DUF77; Region: DUF77; pfam01910 419947005448 Macro domain, Unknown family 2. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_2; cd03330 419947005449 putative ADP-ribose binding site [chemical binding]; other site 419947005450 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 419947005451 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 419947005452 cyclase homology domain; Region: CHD; cd07302 419947005453 nucleotidyl binding site; other site 419947005454 metal binding site [ion binding]; metal-binding site 419947005455 dimer interface [polypeptide binding]; other site 419947005456 competence damage-inducible protein A; Provisional; Region: PRK00549 419947005457 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 419947005458 putative MPT binding site; other site 419947005459 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 419947005460 putative sialic acid transporter; Region: 2A0112; TIGR00891 419947005461 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 419947005462 putative substrate translocation pore; other site 419947005463 Predicted membrane protein [Function unknown]; Region: COG1950 419947005464 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 419947005465 anti sigma factor interaction site; other site 419947005466 regulatory phosphorylation site [posttranslational modification]; other site 419947005467 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 419947005468 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 419947005469 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 419947005470 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 419947005471 dimer interface [polypeptide binding]; other site 419947005472 active site 419947005473 heme binding site [chemical binding]; other site 419947005474 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 419947005475 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 419947005476 metal binding site 2 [ion binding]; metal-binding site 419947005477 putative DNA binding helix; other site 419947005478 metal binding site 1 [ion binding]; metal-binding site 419947005479 dimer interface [polypeptide binding]; other site 419947005480 structural Zn2+ binding site [ion binding]; other site 419947005481 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 419947005482 substrate binding site [chemical binding]; other site 419947005483 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 419947005484 substrate binding site [chemical binding]; other site 419947005485 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 419947005486 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR3; cd08275 419947005487 putative NAD(P) binding site [chemical binding]; other site 419947005488 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 419947005489 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 419947005490 tetramer interface [polypeptide binding]; other site 419947005491 active site 419947005492 Mg2+/Mn2+ binding site [ion binding]; other site 419947005493 Isocitrate lyase [Energy production and conversion]; Region: AceA; COG2224 419947005494 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947005495 PPE family; Region: PPE; pfam00823 419947005496 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947005497 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 419947005498 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 419947005499 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947005500 PPE family; Region: PPE; pfam00823 419947005501 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 419947005502 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 419947005503 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 419947005504 putative hydrophobic ligand binding site [chemical binding]; other site 419947005505 protein interface [polypeptide binding]; other site 419947005506 gate; other site 419947005507 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 419947005508 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 419947005509 putative acyl-acceptor binding pocket; other site 419947005510 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 419947005511 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 419947005512 Beta-lactamase; Region: Beta-lactamase; pfam00144 419947005513 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 419947005514 Beta-lactamase; Region: Beta-lactamase; pfam00144 419947005515 putative fatty-acid--CoA ligase; Provisional; Region: PRK12476 419947005516 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 419947005517 acyl-activating enzyme (AAE) consensus motif; other site 419947005518 active site 419947005519 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 419947005520 Uncharacterized conserved protein [Function unknown]; Region: COG3361 419947005521 short chain dehydrogenase; Provisional; Region: PRK05867 419947005522 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 419947005523 NAD(P) binding site [chemical binding]; other site 419947005524 active site 419947005525 TIGR03085 family protein; Region: TIGR03085 419947005526 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 419947005527 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 419947005528 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 419947005529 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 419947005530 conserved cys residue [active] 419947005531 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 419947005532 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 419947005533 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 419947005534 dimer interface [polypeptide binding]; other site 419947005535 catalytic triad [active] 419947005536 peroxidatic and resolving cysteines [active] 419947005537 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 419947005538 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 419947005539 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 419947005540 active site 419947005541 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 419947005542 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 419947005543 FAD binding site [chemical binding]; other site 419947005544 substrate binding site [chemical binding]; other site 419947005545 catalytic base [active] 419947005546 enoyl-CoA hydratase; Provisional; Region: PRK08290 419947005547 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 419947005548 substrate binding site [chemical binding]; other site 419947005549 oxyanion hole (OAH) forming residues; other site 419947005550 trimer interface [polypeptide binding]; other site 419947005551 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 419947005552 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 419947005553 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 419947005554 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 419947005555 catalytic loop [active] 419947005556 iron binding site [ion binding]; other site 419947005557 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 419947005558 FAD binding pocket [chemical binding]; other site 419947005559 FAD binding motif [chemical binding]; other site 419947005560 phosphate binding motif [ion binding]; other site 419947005561 beta-alpha-beta structure motif; other site 419947005562 NAD binding pocket [chemical binding]; other site 419947005563 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 419947005564 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 419947005565 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 419947005566 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 419947005567 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 419947005568 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 419947005569 dimerization interface [polypeptide binding]; other site 419947005570 active site 419947005571 classical (c) SDR, subgroup 12; Region: SDR_c12; cd08944 419947005572 putative NAD(P) binding site [chemical binding]; other site 419947005573 active site 419947005574 homodimer interface [polypeptide binding]; other site 419947005575 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 419947005576 SEC-C motif; Region: SEC-C; pfam02810 419947005577 Domain of unknown function (DUF222); Region: DUF222; pfam02720 419947005578 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 419947005579 active site 419947005580 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 419947005581 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487 419947005582 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 419947005583 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 419947005584 non-specific DNA binding site [nucleotide binding]; other site 419947005585 salt bridge; other site 419947005586 sequence-specific DNA binding site [nucleotide binding]; other site 419947005587 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 419947005588 Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693 419947005589 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 419947005590 putative active site [active] 419947005591 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 419947005592 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 419947005593 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 419947005594 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 419947005595 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 419947005596 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 419947005597 Permease; Region: Permease; pfam02405 419947005598 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 419947005599 Permease; Region: Permease; pfam02405 419947005600 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 419947005601 mce related protein; Region: MCE; pfam02470 419947005602 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 419947005603 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 419947005604 mce related protein; Region: MCE; pfam02470 419947005605 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 419947005606 mce related protein; Region: MCE; pfam02470 419947005607 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 419947005608 mce related protein; Region: MCE; pfam02470 419947005609 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 419947005610 mce related protein; Region: MCE; pfam02470 419947005611 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 419947005612 mce related protein; Region: MCE; pfam02470 419947005613 Protein of unknown function (DUF732); Region: DUF732; pfam05305 419947005614 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 419947005615 YacP-like NYN domain; Region: NYN_YacP; cl01491 419947005616 Peptidase family M48; Region: Peptidase_M48; pfam01435 419947005617 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 419947005618 S-adenosylmethionine binding site [chemical binding]; other site 419947005619 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 419947005620 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 419947005621 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 419947005622 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 419947005623 dimer interface [polypeptide binding]; other site 419947005624 putative radical transfer pathway; other site 419947005625 diiron center [ion binding]; other site 419947005626 tyrosyl radical; other site 419947005627 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 419947005628 putative active site [active] 419947005629 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 419947005630 PE family; Region: PE; pfam00934 419947005631 Cutinase; Region: Cutinase; pfam01083 419947005632 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 419947005633 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 419947005634 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 419947005635 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 419947005636 dimerization interface [polypeptide binding]; other site 419947005637 Lysine efflux permease [General function prediction only]; Region: COG1279 419947005638 Cellulose binding domain; Region: CBM_2; pfam00553 419947005639 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 419947005640 S-adenosylmethionine binding site [chemical binding]; other site 419947005641 Uncharacterized conserved protein [Function unknown]; Region: COG5654 419947005642 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 419947005643 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 419947005644 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 419947005645 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 419947005646 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 419947005647 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 419947005648 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 419947005649 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 419947005650 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 419947005651 dimerization interface [polypeptide binding]; other site 419947005652 putative DNA binding site [nucleotide binding]; other site 419947005653 putative Zn2+ binding site [ion binding]; other site 419947005654 Hemerythrin-like domain; Region: Hr-like; cd12108 419947005655 Fe binding site [ion binding]; other site 419947005656 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 419947005657 Ligand Binding Site [chemical binding]; other site 419947005658 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 419947005659 Ligand Binding Site [chemical binding]; other site 419947005660 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 419947005661 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 419947005662 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 419947005663 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 419947005664 Soluble P-type ATPase [General function prediction only]; Region: COG4087 419947005665 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 419947005666 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 419947005667 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 419947005668 tetramer interface [polypeptide binding]; other site 419947005669 active site 419947005670 Mg2+/Mn2+ binding site [ion binding]; other site 419947005671 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 419947005672 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 419947005673 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 419947005674 3beta17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 3beta-17beta-HSD_like_SDR_c; cd05341 419947005675 homotetramer interface [polypeptide binding]; other site 419947005676 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 419947005677 NAD binding site [chemical binding]; other site 419947005678 homodimer interface [polypeptide binding]; other site 419947005679 active site 419947005680 Methyltransferase domain; Region: Methyltransf_23; pfam13489 419947005681 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 419947005682 S-adenosylmethionine binding site [chemical binding]; other site 419947005683 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 419947005684 Predicted kinase [General function prediction only]; Region: COG0645 419947005685 AAA domain; Region: AAA_17; pfam13207 419947005686 Universal stress protein family; Region: Usp; pfam00582 419947005687 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 419947005688 Ligand Binding Site [chemical binding]; other site 419947005689 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 419947005690 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 419947005691 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 419947005692 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 419947005693 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 419947005694 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 419947005695 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 419947005696 Ferredoxin [Energy production and conversion]; Region: COG1146 419947005697 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 419947005698 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 419947005699 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 419947005700 Walker A motif; other site 419947005701 ATP binding site [chemical binding]; other site 419947005702 Walker B motif; other site 419947005703 arginine finger; other site 419947005704 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 419947005705 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 419947005706 putative active site [active] 419947005707 Transcriptional regulators [Transcription]; Region: MarR; COG1846 419947005708 MarR family; Region: MarR_2; pfam12802 419947005709 Phage envelope protein [General function prediction only]; Region: COG5562 419947005710 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 419947005711 Transposase; Region: DEDD_Tnp_IS110; pfam01548 419947005712 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 419947005713 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 419947005714 Domain of unknown function (DUF222); Region: DUF222; pfam02720 419947005715 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 419947005716 active site 419947005717 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 419947005718 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 419947005719 non-specific DNA binding site [nucleotide binding]; other site 419947005720 salt bridge; other site 419947005721 sequence-specific DNA binding site [nucleotide binding]; other site 419947005722 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 419947005723 Uncharacterized conserved protein [Function unknown]; Region: COG2442 419947005724 Predicted helicase [General function prediction only]; Region: COG4889 419947005725 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 419947005726 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 419947005727 non-specific DNA binding site [nucleotide binding]; other site 419947005728 salt bridge; other site 419947005729 sequence-specific DNA binding site [nucleotide binding]; other site 419947005730 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4683 419947005731 Restriction endonuclease; Region: Mrr_cat_2; pfam13156 419947005732 DEAD-like helicases superfamily; Region: DEXDc; smart00487 419947005733 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 419947005734 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 419947005735 ATP binding site [chemical binding]; other site 419947005736 putative Mg++ binding site [ion binding]; other site 419947005737 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 419947005738 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 419947005739 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 419947005740 Ligand Binding Site [chemical binding]; other site 419947005741 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 419947005742 Ligand Binding Site [chemical binding]; other site 419947005743 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 419947005744 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 419947005745 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 419947005746 Histidine kinase; Region: HisKA_3; pfam07730 419947005747 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 419947005748 Ligand Binding Site [chemical binding]; other site 419947005749 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 419947005750 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 419947005751 putative substrate binding site [chemical binding]; other site 419947005752 putative ATP binding site [chemical binding]; other site 419947005753 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 419947005754 active site 419947005755 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 419947005756 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 419947005757 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 419947005758 putative dimer interface [polypeptide binding]; other site 419947005759 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 419947005760 dimer interface [polypeptide binding]; other site 419947005761 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 419947005762 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 419947005763 putative DNA binding site [nucleotide binding]; other site 419947005764 dimerization interface [polypeptide binding]; other site 419947005765 putative Zn2+ binding site [ion binding]; other site 419947005766 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 419947005767 putative hydrophobic ligand binding site [chemical binding]; other site 419947005768 CLM binding site; other site 419947005769 L1 loop; other site 419947005770 DNA binding site [nucleotide binding] 419947005771 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 419947005772 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 419947005773 MDMPI C-terminal domain; Region: MDMPI_C; pfam07398 419947005774 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 419947005775 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 419947005776 nucleophile elbow; other site 419947005777 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 419947005778 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 419947005779 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 419947005780 Walker A/P-loop; other site 419947005781 ATP binding site [chemical binding]; other site 419947005782 Q-loop/lid; other site 419947005783 ABC transporter signature motif; other site 419947005784 Walker B; other site 419947005785 D-loop; other site 419947005786 H-loop/switch region; other site 419947005787 TOBE domain; Region: TOBE_2; pfam08402 419947005788 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 419947005789 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 419947005790 dimer interface [polypeptide binding]; other site 419947005791 conserved gate region; other site 419947005792 putative PBP binding loops; other site 419947005793 ABC-ATPase subunit interface; other site 419947005794 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 419947005795 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 419947005796 dimer interface [polypeptide binding]; other site 419947005797 conserved gate region; other site 419947005798 putative PBP binding loops; other site 419947005799 ABC-ATPase subunit interface; other site 419947005800 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 419947005801 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 419947005802 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 419947005803 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 419947005804 Isochorismatase family; Region: Isochorismatase; pfam00857 419947005805 catalytic triad [active] 419947005806 metal binding site [ion binding]; metal-binding site 419947005807 conserved cis-peptide bond; other site 419947005808 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 419947005809 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 419947005810 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 419947005811 substrate binding pocket [chemical binding]; other site 419947005812 catalytic triad [active] 419947005813 hypothetical protein; Provisional; Region: PRK05865 419947005814 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 419947005815 NAD(P) binding site [chemical binding]; other site 419947005816 active site 419947005817 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 419947005818 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 419947005819 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 419947005820 active site 419947005821 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 419947005822 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 419947005823 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 419947005824 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 419947005825 Enoylreductase; Region: PKS_ER; smart00829 419947005826 NAD(P) binding site [chemical binding]; other site 419947005827 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 419947005828 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 419947005829 putative NADP binding site [chemical binding]; other site 419947005830 active site 419947005831 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 419947005832 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 419947005833 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 419947005834 active site 419947005835 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 419947005836 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 419947005837 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 419947005838 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 419947005839 Enoylreductase; Region: PKS_ER; smart00829 419947005840 NAD(P) binding site [chemical binding]; other site 419947005841 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 419947005842 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 419947005843 putative NADP binding site [chemical binding]; other site 419947005844 active site 419947005845 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 419947005846 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 419947005847 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 419947005848 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 419947005849 putative active site [active] 419947005850 catalytic triad [active] 419947005851 putative dimer interface [polypeptide binding]; other site 419947005852 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 419947005853 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 419947005854 Ligand binding site; other site 419947005855 Putative Catalytic site; other site 419947005856 DXD motif; other site 419947005857 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 419947005858 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 419947005859 active site 419947005860 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 419947005861 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 419947005862 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 419947005863 30S ribosomal protein S18; Provisional; Region: PRK13401 419947005864 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 419947005865 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 419947005866 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 419947005867 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 419947005868 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 419947005869 intersubunit interface [polypeptide binding]; other site 419947005870 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 419947005871 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 419947005872 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 419947005873 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 419947005874 PemK-like protein; Region: PemK; pfam02452 419947005875 precorrin-3B synthase; Region: CobG; TIGR02435 419947005876 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 419947005877 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 419947005878 Precorrin-8X methylmutase; Region: CbiC; pfam02570 419947005879 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 419947005880 active site 419947005881 SAM binding site [chemical binding]; other site 419947005882 homodimer interface [polypeptide binding]; other site 419947005883 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 419947005884 active site 419947005885 SAM binding site [chemical binding]; other site 419947005886 homodimer interface [polypeptide binding]; other site 419947005887 Methyltransferase domain; Region: Methyltransf_31; pfam13847 419947005888 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 419947005889 S-adenosylmethionine binding site [chemical binding]; other site 419947005890 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 419947005891 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 419947005892 RNA polymerase sigma factor SigC; Reviewed; Region: PRK09649 419947005893 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 419947005894 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 419947005895 DNA binding residues [nucleotide binding] 419947005896 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 419947005897 precorrin-6x reductase; Region: precor6x_red; TIGR00715 419947005898 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 419947005899 active site 419947005900 SAM binding site [chemical binding]; other site 419947005901 homodimer interface [polypeptide binding]; other site 419947005902 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 419947005903 active site 419947005904 putative homodimer interface [polypeptide binding]; other site 419947005905 SAM binding site [chemical binding]; other site 419947005906 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 419947005907 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 419947005908 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 419947005909 NAD(P) binding site [chemical binding]; other site 419947005910 active site 419947005911 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 419947005912 Catalytic domain of uncharacterized Mycobacterium tuberculosis Rv2075c-like proteins; Region: PI-PLCc_Rv2075c_like; cd08590 419947005913 putative active site [active] 419947005914 catalytic site [active] 419947005915 putative metal binding site [ion binding]; other site 419947005916 C-type lectin (CTL)/C-type lectin-like (CTLD) domain; Region: CLECT; cl02432 419947005917 Protein of unknown function (DUF2563); Region: DUF2563; pfam10817 419947005918 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 419947005919 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 419947005920 Catalytic domain of Protein Kinases; Region: PKc; cd00180 419947005921 active site 419947005922 ATP binding site [chemical binding]; other site 419947005923 substrate binding site [chemical binding]; other site 419947005924 activation loop (A-loop); other site 419947005925 PknH-like extracellular domain; Region: PknH_C; pfam14032 419947005926 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 419947005927 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 419947005928 active site 419947005929 5'-3' exonuclease; Region: 53EXOc; smart00475 419947005930 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 419947005931 active site 419947005932 metal binding site 1 [ion binding]; metal-binding site 419947005933 putative 5' ssDNA interaction site; other site 419947005934 metal binding site 3; metal-binding site 419947005935 metal binding site 2 [ion binding]; metal-binding site 419947005936 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 419947005937 putative DNA binding site [nucleotide binding]; other site 419947005938 putative metal binding site [ion binding]; other site 419947005939 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 419947005940 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 419947005941 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 419947005942 ATP binding site [chemical binding]; other site 419947005943 putative Mg++ binding site [ion binding]; other site 419947005944 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 419947005945 nucleotide binding region [chemical binding]; other site 419947005946 ATP-binding site [chemical binding]; other site 419947005947 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 419947005948 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 419947005949 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 419947005950 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 419947005951 Predicted transcriptional regulator [Transcription]; Region: COG2378 419947005952 WYL domain; Region: WYL; pfam13280 419947005953 Predicted transcriptional regulator [Transcription]; Region: COG2378 419947005954 WYL domain; Region: WYL; pfam13280 419947005955 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 419947005956 Domain of unknown function (DUF222); Region: DUF222; pfam02720 419947005957 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 419947005958 active site 419947005959 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 419947005960 SNF2 Helicase protein; Region: DUF3670; pfam12419 419947005961 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 419947005962 ATP binding site [chemical binding]; other site 419947005963 putative Mg++ binding site [ion binding]; other site 419947005964 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 419947005965 nucleotide binding region [chemical binding]; other site 419947005966 ATP-binding site [chemical binding]; other site 419947005967 Uncharacterized conserved protein [Function unknown]; Region: COG4279 419947005968 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 419947005969 putative active site [active] 419947005970 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 419947005971 Transposase; Region: HTH_Tnp_1; cl17663 419947005972 putative transposase OrfB; Reviewed; Region: PHA02517 419947005973 HTH-like domain; Region: HTH_21; pfam13276 419947005974 Integrase core domain; Region: rve; pfam00665 419947005975 Integrase core domain; Region: rve_3; pfam13683 419947005976 PE family; Region: PE; pfam00934 419947005977 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947005978 PPE family; Region: PPE; pfam00823 419947005979 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 419947005980 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 419947005981 active site 419947005982 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 419947005983 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 419947005984 active site 419947005985 Pup-like protein; Region: Pup; pfam05639 419947005986 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 419947005987 proteasome ATPase; Region: pup_AAA; TIGR03689 419947005988 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 419947005989 Walker A motif; other site 419947005990 ATP binding site [chemical binding]; other site 419947005991 Walker B motif; other site 419947005992 arginine finger; other site 419947005993 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 419947005994 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550 419947005995 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 419947005996 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 419947005997 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 419947005998 Predicted membrane protein [Function unknown]; Region: COG3918 419947005999 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 419947006000 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 419947006001 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 419947006002 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 419947006003 homodimer interface [polypeptide binding]; other site 419947006004 putative metal binding site [ion binding]; other site 419947006005 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947006006 PPE family; Region: PPE; pfam00823 419947006007 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 419947006008 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 419947006009 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 419947006010 substrate binding pocket [chemical binding]; other site 419947006011 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 419947006012 B12 binding site [chemical binding]; other site 419947006013 cobalt ligand [ion binding]; other site 419947006014 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 419947006015 PAC2 family; Region: PAC2; pfam09754 419947006016 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 419947006017 short chain dehydrogenase; Provisional; Region: PRK05872 419947006018 classical (c) SDRs; Region: SDR_c; cd05233 419947006019 NAD(P) binding site [chemical binding]; other site 419947006020 active site 419947006021 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 419947006022 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 419947006023 active site 419947006024 HIGH motif; other site 419947006025 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 419947006026 active site 419947006027 KMSKS motif; other site 419947006028 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 419947006029 putative tRNA binding surface [nucleotide binding]; other site 419947006030 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 419947006031 active site 419947006032 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 419947006033 conserved hypothetical protein; Region: TIGR03843 419947006034 conserved hypothetical protein; Region: TIGR03847 419947006035 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 419947006036 catalytic core [active] 419947006037 undecaprenyl-diphosphatase UppP; Region: undec_PP_bacA; TIGR00753 419947006038 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 419947006039 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 419947006040 quinone interaction residues [chemical binding]; other site 419947006041 active site 419947006042 catalytic residues [active] 419947006043 FMN binding site [chemical binding]; other site 419947006044 substrate binding site [chemical binding]; other site 419947006045 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 419947006046 substrate binding site [chemical binding]; other site 419947006047 hypothetical protein; Provisional; Region: PRK07906 419947006048 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 419947006049 putative metal binding site [ion binding]; other site 419947006050 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 419947006051 putative addiction module component, TIGR02574 family; Region: stabl_TIGR02574 419947006052 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 419947006053 active site 419947006054 DivIVA domain; Region: DivI1A_domain; TIGR03544 419947006055 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 419947006056 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 419947006057 Predicted integral membrane protein [Function unknown]; Region: COG0762 419947006058 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 419947006059 Predicted enzyme with a TIM-barrel fold [General function prediction only]; Region: COG0325 419947006060 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 419947006061 catalytic residue [active] 419947006062 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 419947006063 uncharacterized protein, YfiH family; Region: TIGR00726 419947006064 cell division protein FtsZ; Validated; Region: PRK09330 419947006065 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 419947006066 nucleotide binding site [chemical binding]; other site 419947006067 SulA interaction site; other site 419947006068 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 419947006069 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 419947006070 Cell division protein FtsQ; Region: FtsQ; pfam03799 419947006071 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 419947006072 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 419947006073 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 419947006074 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 419947006075 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 419947006076 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 419947006077 active site 419947006078 homodimer interface [polypeptide binding]; other site 419947006079 cell division protein FtsW; Region: ftsW; TIGR02614 419947006080 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369 419947006081 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 419947006082 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 419947006083 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 419947006084 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 419947006085 Mg++ binding site [ion binding]; other site 419947006086 putative catalytic motif [active] 419947006087 putative substrate binding site [chemical binding]; other site 419947006088 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 419947006089 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 419947006090 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 419947006091 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 419947006092 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 419947006093 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 419947006094 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 419947006095 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 419947006096 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 419947006097 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 419947006098 PE family; Region: PE; pfam00934 419947006099 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 419947006100 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 419947006101 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 419947006102 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 419947006103 MraW methylase family; Region: Methyltransf_5; pfam01795 419947006104 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 419947006105 MraZ protein; Region: MraZ; pfam02381 419947006106 MraZ protein; Region: MraZ; pfam02381 419947006107 putative transposase OrfB; Reviewed; Region: PHA02517 419947006108 HTH-like domain; Region: HTH_21; pfam13276 419947006109 Integrase core domain; Region: rve; pfam00665 419947006110 Integrase core domain; Region: rve_3; pfam13683 419947006111 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 419947006112 Transposase; Region: HTH_Tnp_1; cl17663 419947006113 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 419947006114 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 419947006115 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 419947006116 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 419947006117 substrate binding pocket [chemical binding]; other site 419947006118 chain length determination region; other site 419947006119 substrate-Mg2+ binding site; other site 419947006120 catalytic residues [active] 419947006121 aspartate-rich region 1; other site 419947006122 active site lid residues [active] 419947006123 aspartate-rich region 2; other site 419947006124 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 419947006125 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 419947006126 Catalytic domain of Protein Kinases; Region: PKc; cd00180 419947006127 active site 419947006128 ATP binding site [chemical binding]; other site 419947006129 substrate binding site [chemical binding]; other site 419947006130 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 419947006131 substrate binding site [chemical binding]; other site 419947006132 activation loop (A-loop); other site 419947006133 activation loop (A-loop); other site 419947006134 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 419947006135 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 419947006136 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG3200 419947006137 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 419947006138 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 419947006139 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 419947006140 putative acyl-acceptor binding pocket; other site 419947006141 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 419947006142 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 419947006143 DTAP/Switch II; other site 419947006144 Switch I; other site 419947006145 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 419947006146 putative hydrophobic ligand binding site [chemical binding]; other site 419947006147 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 419947006148 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 419947006149 acyl-activating enzyme (AAE) consensus motif; other site 419947006150 putative AMP binding site [chemical binding]; other site 419947006151 putative active site [active] 419947006152 putative CoA binding site [chemical binding]; other site 419947006153 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 419947006154 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 419947006155 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 419947006156 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 419947006157 NlpC/P60 family; Region: NLPC_P60; pfam00877 419947006158 hypothetical protein; Validated; Region: PRK07883 419947006159 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 419947006160 active site 419947006161 catalytic site [active] 419947006162 substrate binding site [chemical binding]; other site 419947006163 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 419947006164 GIY-YIG motif/motif A; other site 419947006165 active site 419947006166 catalytic site [active] 419947006167 putative DNA binding site [nucleotide binding]; other site 419947006168 metal binding site [ion binding]; metal-binding site 419947006169 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 419947006170 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 419947006171 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 419947006172 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 419947006173 Subunit I/III interface [polypeptide binding]; other site 419947006174 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 419947006175 Cytochrome c; Region: Cytochrom_C; pfam00034 419947006176 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 419947006177 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 419947006178 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 419947006179 iron-sulfur cluster [ion binding]; other site 419947006180 [2Fe-2S] cluster binding site [ion binding]; other site 419947006181 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 419947006182 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 419947006183 heme bH binding site [chemical binding]; other site 419947006184 intrachain domain interface; other site 419947006185 heme bL binding site [chemical binding]; other site 419947006186 interchain domain interface [polypeptide binding]; other site 419947006187 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 419947006188 Qo binding site; other site 419947006189 Protein of unknown function (DUF2561); Region: DUF2561; pfam10812 419947006190 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 419947006191 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 419947006192 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 419947006193 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 419947006194 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 419947006195 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 419947006196 dimer interface [polypeptide binding]; other site 419947006197 active site 419947006198 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 419947006199 Ligand Binding Site [chemical binding]; other site 419947006200 Molecular Tunnel; other site 419947006201 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 419947006202 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 419947006203 substrate binding site [chemical binding]; other site 419947006204 ATP binding site [chemical binding]; other site 419947006205 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 419947006206 Glycerate kinase family; Region: Gly_kinase; pfam02595 419947006207 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 419947006208 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 419947006209 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 419947006210 putative dimer interface [polypeptide binding]; other site 419947006211 active site pocket [active] 419947006212 putative cataytic base [active] 419947006213 Cobalamin-5-phosphate synthase; Region: CobS; pfam02654 419947006214 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 419947006215 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 419947006216 homodimer interface [polypeptide binding]; other site 419947006217 substrate-cofactor binding pocket; other site 419947006218 catalytic residue [active] 419947006219 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 419947006220 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 419947006221 cyclase homology domain; Region: CHD; cd07302 419947006222 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 419947006223 nucleotidyl binding site; other site 419947006224 metal binding site [ion binding]; metal-binding site 419947006225 dimer interface [polypeptide binding]; other site 419947006226 multifunctional aminopeptidase A; Provisional; Region: PRK00913 419947006227 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 419947006228 interface (dimer of trimers) [polypeptide binding]; other site 419947006229 Substrate-binding/catalytic site; other site 419947006230 Zn-binding sites [ion binding]; other site 419947006231 short chain dehydrogenase; Validated; Region: PRK05855 419947006232 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 419947006233 classical (c) SDRs; Region: SDR_c; cd05233 419947006234 NAD(P) binding site [chemical binding]; other site 419947006235 active site 419947006236 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 419947006237 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 419947006238 E3 interaction surface; other site 419947006239 lipoyl attachment site [posttranslational modification]; other site 419947006240 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 419947006241 E3 interaction surface; other site 419947006242 lipoyl attachment site [posttranslational modification]; other site 419947006243 e3 binding domain; Region: E3_binding; pfam02817 419947006244 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 419947006245 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 419947006246 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 419947006247 putative NAD(P) binding site [chemical binding]; other site 419947006248 putative active site [active] 419947006249 lipoate-protein ligase B; Provisional; Region: PRK14345 419947006250 lipoyl synthase; Provisional; Region: PRK05481 419947006251 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 419947006252 FeS/SAM binding site; other site 419947006253 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 419947006254 RDD family; Region: RDD; pfam06271 419947006255 glutamine synthetase, type I; Region: GlnA; TIGR00653 419947006256 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 419947006257 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 419947006258 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 419947006259 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 419947006260 metal binding triad; other site 419947006261 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 419947006262 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 419947006263 metal binding triad; other site 419947006264 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 419947006265 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 419947006266 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 419947006267 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 419947006268 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 419947006269 TAP-like protein; Region: Abhydrolase_4; pfam08386 419947006270 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 419947006271 TAP-like protein; Region: Abhydrolase_4; pfam08386 419947006272 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 419947006273 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 419947006274 oligomerization interface [polypeptide binding]; other site 419947006275 active site 419947006276 metal binding site [ion binding]; metal-binding site 419947006277 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 419947006278 putative active site; other site 419947006279 putative metal binding residues [ion binding]; other site 419947006280 signature motif; other site 419947006281 putative triphosphate binding site [ion binding]; other site 419947006282 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 419947006283 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; cl17606 419947006284 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 419947006285 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 419947006286 RNA/DNA hybrid binding site [nucleotide binding]; other site 419947006287 active site 419947006288 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 419947006289 catalytic core [active] 419947006290 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 419947006291 Putative zinc ribbon domain; Region: DUF164; pfam02591 419947006292 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 419947006293 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 419947006294 Uncharacterized conserved protein [Function unknown]; Region: COG0327 419947006295 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 419947006296 hypothetical protein; Provisional; Region: PRK07908 419947006297 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 419947006298 pyridoxal 5'-phosphate binding site [chemical binding]; other site 419947006299 homodimer interface [polypeptide binding]; other site 419947006300 catalytic residue [active] 419947006301 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 419947006302 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 419947006303 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 419947006304 active site 419947006305 motif I; other site 419947006306 motif II; other site 419947006307 Low molecular weight phosphatase family; Region: LMWPc; cd00115 419947006308 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 419947006309 active site 419947006310 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 419947006311 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 419947006312 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 419947006313 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 419947006314 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 419947006315 dimer interface [polypeptide binding]; other site 419947006316 catalytic triad [active] 419947006317 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 419947006318 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 419947006319 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 419947006320 dimer interface [polypeptide binding]; other site 419947006321 TPP-binding site [chemical binding]; other site 419947006322 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 419947006323 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 419947006324 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 419947006325 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 419947006326 acyl carrier protein; Provisional; Region: acpP; PRK00982 419947006327 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 419947006328 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 419947006329 dimer interface [polypeptide binding]; other site 419947006330 active site 419947006331 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 419947006332 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 419947006333 dimer interface [polypeptide binding]; other site 419947006334 active site 419947006335 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 419947006336 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 419947006337 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 419947006338 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 419947006339 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 419947006340 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 419947006341 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 419947006342 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 419947006343 FAD binding domain; Region: FAD_binding_4; pfam01565 419947006344 diacylglycerol kinase; Reviewed; Region: PRK11914 419947006345 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 419947006346 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 419947006347 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 419947006348 Beta-lactamase; Region: Beta-lactamase; pfam00144 419947006349 Methyltransferase domain; Region: Methyltransf_31; pfam13847 419947006350 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 419947006351 S-adenosylmethionine binding site [chemical binding]; other site 419947006352 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 419947006353 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 419947006354 NAD binding site [chemical binding]; other site 419947006355 catalytic Zn binding site [ion binding]; other site 419947006356 substrate binding site [chemical binding]; other site 419947006357 structural Zn binding site [ion binding]; other site 419947006358 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 419947006359 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 419947006360 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 419947006361 active site 419947006362 dimer interface [polypeptide binding]; other site 419947006363 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 419947006364 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 419947006365 catalytic triad [active] 419947006366 short chain dehydrogenase; Provisional; Region: PRK05854 419947006367 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 419947006368 putative NAD(P) binding site [chemical binding]; other site 419947006369 active site 419947006370 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 419947006371 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 419947006372 nucleotide binding site [chemical binding]; other site 419947006373 Major Facilitator Superfamily; Region: MFS_1; pfam07690 419947006374 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 419947006375 Cytochrome P450; Region: p450; cl12078 419947006376 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 419947006377 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 419947006378 Cytochrome P450; Region: p450; cl12078 419947006379 Septum formation; Region: Septum_form; pfam13845 419947006380 Protein of unknown function (DUF2695); Region: DUF2695; pfam10905 419947006381 Predicted membrane protein [Function unknown]; Region: COG2149 419947006382 Domain of unknown function (DUF202); Region: DUF202; pfam02656 419947006383 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 419947006384 Cytochrome P450; Region: p450; cl12078 419947006385 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial protein Rv2277c and similar proteins; Region: GDPD_Rv2277c_like; cd08580 419947006386 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 419947006387 putative active site [active] 419947006388 catalytic site [active] 419947006389 putative metal binding site [ion binding]; other site 419947006390 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 419947006391 Transposase; Region: HTH_Tnp_1; cl17663 419947006392 putative transposase OrfB; Reviewed; Region: PHA02517 419947006393 HTH-like domain; Region: HTH_21; pfam13276 419947006394 Integrase core domain; Region: rve; pfam00665 419947006395 Integrase core domain; Region: rve_3; pfam13683 419947006396 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 419947006397 FAD binding domain; Region: FAD_binding_4; pfam01565 419947006398 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 419947006399 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 419947006400 Transcriptional regulator [Transcription]; Region: LysR; COG0583 419947006401 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 419947006402 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 419947006403 dimerization interface [polypeptide binding]; other site 419947006404 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 419947006405 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 419947006406 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 419947006407 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 419947006408 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 419947006409 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 419947006410 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 419947006411 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 419947006412 CDP-diacylglycerol pyrophosphatase [Lipid metabolism]; Region: Cdh; COG2134 419947006413 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 419947006414 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 419947006415 active site residue [active] 419947006416 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 419947006417 active site residue [active] 419947006418 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 419947006419 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 419947006420 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 419947006421 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 419947006422 pyridoxal 5'-phosphate binding site [chemical binding]; other site 419947006423 homodimer interface [polypeptide binding]; other site 419947006424 catalytic residue [active] 419947006425 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3196 419947006426 haloalkane dehalogenase; Provisional; Region: PRK00870 419947006427 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 419947006428 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 419947006429 active site 419947006430 catalytic tetrad [active] 419947006431 heat shock protein 90; Provisional; Region: PRK05218 419947006432 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 419947006433 ATP binding site [chemical binding]; other site 419947006434 Mg2+ binding site [ion binding]; other site 419947006435 G-X-G motif; other site 419947006436 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 419947006437 Cutinase; Region: Cutinase; pfam01083 419947006438 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 419947006439 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 419947006440 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 419947006441 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 419947006442 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 419947006443 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 419947006444 Excalibur calcium-binding domain; Region: Excalibur; smart00894 419947006445 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 419947006446 Uncharacterized conserved protein [Function unknown]; Region: COG2442 419947006447 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 419947006448 DNA binding site [nucleotide binding] 419947006449 active site 419947006450 Int/Topo IB signature motif; other site 419947006451 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 419947006452 DNA binding residues [nucleotide binding] 419947006453 Family description; Region: UvrD_C_2; pfam13538 419947006454 Uncharacterized conserved protein [Function unknown]; Region: COG2128 419947006455 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 419947006456 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 419947006457 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 419947006458 putative PBP binding loops; other site 419947006459 ABC-ATPase subunit interface; other site 419947006460 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 419947006461 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 419947006462 dimer interface [polypeptide binding]; other site 419947006463 conserved gate region; other site 419947006464 putative PBP binding loops; other site 419947006465 ABC-ATPase subunit interface; other site 419947006466 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 419947006467 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 419947006468 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 419947006469 Ligand Binding Site [chemical binding]; other site 419947006470 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 419947006471 Ligand Binding Site [chemical binding]; other site 419947006472 amino acid transporter; Region: 2A0306; TIGR00909 419947006473 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 419947006474 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 419947006475 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 419947006476 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 419947006477 catalytic residue [active] 419947006478 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 419947006479 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 419947006480 Amidinotransferase; Region: Amidinotransf; pfam02274 419947006481 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 419947006482 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 419947006483 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 419947006484 putative DNA binding site [nucleotide binding]; other site 419947006485 putative Zn2+ binding site [ion binding]; other site 419947006486 AsnC family; Region: AsnC_trans_reg; pfam01037 419947006487 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 419947006488 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 419947006489 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 419947006490 Walker A/P-loop; other site 419947006491 ATP binding site [chemical binding]; other site 419947006492 Q-loop/lid; other site 419947006493 ABC transporter signature motif; other site 419947006494 Walker B; other site 419947006495 D-loop; other site 419947006496 H-loop/switch region; other site 419947006497 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 419947006498 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 419947006499 Walker A/P-loop; other site 419947006500 ATP binding site [chemical binding]; other site 419947006501 Q-loop/lid; other site 419947006502 ABC transporter signature motif; other site 419947006503 Walker B; other site 419947006504 D-loop; other site 419947006505 H-loop/switch region; other site 419947006506 MarR family; Region: MarR; pfam01047 419947006507 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 419947006508 PE family; Region: PE; pfam00934 419947006509 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 419947006510 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 419947006511 putative substrate translocation pore; other site 419947006512 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 419947006513 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 419947006514 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 419947006515 malate dehydrogenase; Provisional; Region: PRK13529 419947006516 Malic enzyme, N-terminal domain; Region: malic; pfam00390 419947006517 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 419947006518 NAD(P) binding site [chemical binding]; other site 419947006519 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 419947006520 Major Facilitator Superfamily; Region: MFS_1; pfam07690 419947006521 putative substrate translocation pore; other site 419947006522 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 419947006523 putative substrate translocation pore; other site 419947006524 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 419947006525 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 419947006526 dimer interface [polypeptide binding]; other site 419947006527 pyridoxal 5'-phosphate binding site [chemical binding]; other site 419947006528 catalytic residue [active] 419947006529 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 419947006530 serine O-acetyltransferase; Region: cysE; TIGR01172 419947006531 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 419947006532 trimer interface [polypeptide binding]; other site 419947006533 active site 419947006534 substrate binding site [chemical binding]; other site 419947006535 CoA binding site [chemical binding]; other site 419947006536 hypothetical protein; Provisional; Region: PRK14851 419947006537 hypothetical protein; Validated; Region: PRK08223 419947006538 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 419947006539 ATP binding site [chemical binding]; other site 419947006540 substrate interface [chemical binding]; other site 419947006541 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 419947006542 PE family; Region: PE; pfam00934 419947006543 DNA primase; Validated; Region: dnaG; PRK05667 419947006544 CHC2 zinc finger; Region: zf-CHC2; pfam01807 419947006545 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 419947006546 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 419947006547 active site 419947006548 metal binding site [ion binding]; metal-binding site 419947006549 interdomain interaction site; other site 419947006550 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 419947006551 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 419947006552 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 419947006553 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 419947006554 Zn2+ binding site [ion binding]; other site 419947006555 Mg2+ binding site [ion binding]; other site 419947006556 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 419947006557 Repair protein; Region: Repair_PSII; pfam04536 419947006558 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 419947006559 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 419947006560 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 419947006561 Phosphoesterase family; Region: Phosphoesterase; pfam04185 419947006562 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 419947006563 Phosphoesterase family; Region: Phosphoesterase; pfam04185 419947006564 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 419947006565 Phosphoesterase family; Region: Phosphoesterase; pfam04185 419947006566 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947006567 PPE family; Region: PPE; pfam00823 419947006568 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 419947006569 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 419947006570 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947006571 PPE family; Region: PPE; pfam00823 419947006572 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 419947006573 Transposase; Region: HTH_Tnp_1; cl17663 419947006574 putative transposase OrfB; Reviewed; Region: PHA02517 419947006575 HTH-like domain; Region: HTH_21; pfam13276 419947006576 Integrase core domain; Region: rve; pfam00665 419947006577 Integrase core domain; Region: rve_3; pfam13683 419947006578 PPE family; Region: PPE; pfam00823 419947006579 PPE family; Region: PPE; pfam00823 419947006580 glycyl-tRNA synthetase; Provisional; Region: PRK04173 419947006581 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 419947006582 motif 1; other site 419947006583 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 419947006584 active site 419947006585 motif 2; other site 419947006586 motif 3; other site 419947006587 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 419947006588 anticodon binding site; other site 419947006589 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 419947006590 dimerization interface [polypeptide binding]; other site 419947006591 putative DNA binding site [nucleotide binding]; other site 419947006592 putative Zn2+ binding site [ion binding]; other site 419947006593 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 419947006594 metal binding site 2 [ion binding]; metal-binding site 419947006595 putative DNA binding helix; other site 419947006596 metal binding site 1 [ion binding]; metal-binding site 419947006597 dimer interface [polypeptide binding]; other site 419947006598 structural Zn2+ binding site [ion binding]; other site 419947006599 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 419947006600 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 419947006601 catalytic residue [active] 419947006602 putative FPP diphosphate binding site; other site 419947006603 putative FPP binding hydrophobic cleft; other site 419947006604 dimer interface [polypeptide binding]; other site 419947006605 putative IPP diphosphate binding site; other site 419947006606 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 419947006607 Recombination protein O N terminal; Region: RecO_N; pfam11967 419947006608 Recombination protein O C terminal; Region: RecO_C; pfam02565 419947006609 amidase; Provisional; Region: PRK06061 419947006610 Amidase; Region: Amidase; pfam01425 419947006611 GTPase Era; Reviewed; Region: era; PRK00089 419947006612 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 419947006613 G1 box; other site 419947006614 GTP/Mg2+ binding site [chemical binding]; other site 419947006615 Switch I region; other site 419947006616 G2 box; other site 419947006617 Switch II region; other site 419947006618 G3 box; other site 419947006619 G4 box; other site 419947006620 G5 box; other site 419947006621 KH domain; Region: KH_2; pfam07650 419947006622 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 419947006623 Domain of unknown function DUF21; Region: DUF21; pfam01595 419947006624 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 419947006625 Transporter associated domain; Region: CorC_HlyC; smart01091 419947006626 metal-binding heat shock protein; Provisional; Region: PRK00016 419947006627 K homology RNA-binding domain; Region: KH; smart00322 419947006628 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 419947006629 PhoH-like protein; Region: PhoH; pfam02562 419947006630 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 419947006631 PE family; Region: PE; pfam00934 419947006632 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 419947006633 RNA methyltransferase, RsmE family; Region: TIGR00046 419947006634 chaperone protein DnaJ; Provisional; Region: PRK14278 419947006635 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 419947006636 HSP70 interaction site [polypeptide binding]; other site 419947006637 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 419947006638 Zn binding sites [ion binding]; other site 419947006639 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 419947006640 dimer interface [polypeptide binding]; other site 419947006641 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 419947006642 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 419947006643 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 419947006644 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 419947006645 Condensation domain; Region: Condensation; pfam00668 419947006646 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 419947006647 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 419947006648 acyl-activating enzyme (AAE) consensus motif; other site 419947006649 AMP binding site [chemical binding]; other site 419947006650 Condensation domain; Region: Condensation; pfam00668 419947006651 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 419947006652 Condensation domain; Region: Condensation; pfam00668 419947006653 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 419947006654 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 419947006655 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 419947006656 acyl-activating enzyme (AAE) consensus motif; other site 419947006657 AMP binding site [chemical binding]; other site 419947006658 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 419947006659 Condensation domain; Region: Condensation; pfam00668 419947006660 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 419947006661 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 419947006662 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 419947006663 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 419947006664 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 419947006665 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 419947006666 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 419947006667 NADP binding site [chemical binding]; other site 419947006668 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 419947006669 active site 419947006670 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 419947006671 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 419947006672 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 419947006673 active site 419947006674 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 419947006675 Condensation domain; Region: Condensation; pfam00668 419947006676 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 419947006677 Nonribosomal peptide synthase; Region: NRPS; pfam08415 419947006678 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 419947006679 acyl-activating enzyme (AAE) consensus motif; other site 419947006680 AMP binding site [chemical binding]; other site 419947006681 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 419947006682 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 419947006683 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 419947006684 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 419947006685 acyl-activating enzyme (AAE) consensus motif; other site 419947006686 active site 419947006687 AMP binding site [chemical binding]; other site 419947006688 substrate binding site [chemical binding]; other site 419947006689 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 419947006690 salicylate synthase MbtI; Reviewed; Region: PRK07912 419947006691 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 419947006692 Predicted permease [General function prediction only]; Region: COG3329 419947006693 coproporphyrinogen III oxidase; Validated; Region: PRK05628 419947006694 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 419947006695 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 419947006696 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 419947006697 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 419947006698 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 419947006699 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 419947006700 Active Sites [active] 419947006701 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 419947006702 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 419947006703 putative active site [active] 419947006704 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 419947006705 putative active site [active] 419947006706 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 419947006707 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 419947006708 Predicted membrane protein [Function unknown]; Region: COG1297 419947006709 putative oligopeptide transporter, OPT family; Region: TIGR00733 419947006710 PE family; Region: PE; pfam00934 419947006711 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 419947006712 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 419947006713 Walker A/P-loop; other site 419947006714 ATP binding site [chemical binding]; other site 419947006715 Q-loop/lid; other site 419947006716 ABC transporter signature motif; other site 419947006717 Walker B; other site 419947006718 D-loop; other site 419947006719 H-loop/switch region; other site 419947006720 sulfate transport protein; Provisional; Region: cysT; CHL00187 419947006721 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 419947006722 dimer interface [polypeptide binding]; other site 419947006723 conserved gate region; other site 419947006724 putative PBP binding loops; other site 419947006725 ABC-ATPase subunit interface; other site 419947006726 sulfate transport protein; Provisional; Region: cysT; CHL00187 419947006727 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 419947006728 dimer interface [polypeptide binding]; other site 419947006729 conserved gate region; other site 419947006730 putative PBP binding loops; other site 419947006731 ABC-ATPase subunit interface; other site 419947006732 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 419947006733 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 419947006734 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 419947006735 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 419947006736 PknH-like extracellular domain; Region: PknH_C; pfam14032 419947006737 GTP-binding protein LepA; Provisional; Region: PRK05433 419947006738 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 419947006739 G1 box; other site 419947006740 putative GEF interaction site [polypeptide binding]; other site 419947006741 GTP/Mg2+ binding site [chemical binding]; other site 419947006742 Switch I region; other site 419947006743 G2 box; other site 419947006744 G3 box; other site 419947006745 Switch II region; other site 419947006746 G4 box; other site 419947006747 G5 box; other site 419947006748 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 419947006749 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 419947006750 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 419947006751 PemK-like protein; Region: PemK; pfam02452 419947006752 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 419947006753 FOG: CBS domain [General function prediction only]; Region: COG0517 419947006754 ribonuclease Z; Reviewed; Region: PRK00055 419947006755 PE family; Region: PE; pfam00934 419947006756 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 419947006757 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 419947006758 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 419947006759 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 419947006760 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 419947006761 Uncharacterized conserved protein [Function unknown]; Region: COG2308 419947006762 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 419947006763 hypothetical protein; Reviewed; Region: PRK07914 419947006764 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 419947006765 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 419947006766 Competence protein; Region: Competence; pfam03772 419947006767 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 419947006768 Helix-hairpin-helix motif; Region: HHH; pfam00633 419947006769 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 419947006770 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 419947006771 Coenzyme A binding pocket [chemical binding]; other site 419947006772 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 419947006773 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 419947006774 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 419947006775 active site 419947006776 catalytic triad [active] 419947006777 oxyanion hole [active] 419947006778 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 419947006779 catalytic core [active] 419947006780 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 419947006781 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 419947006782 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 419947006783 active site 419947006784 (T/H)XGH motif; other site 419947006785 Methyltransferase domain; Region: Methyltransf_23; pfam13489 419947006786 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 419947006787 S-adenosylmethionine binding site [chemical binding]; other site 419947006788 Transposase; Region: DEDD_Tnp_IS110; pfam01548 419947006789 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 419947006790 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 419947006791 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 419947006792 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 419947006793 metal ion-dependent adhesion site (MIDAS); other site 419947006794 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 419947006795 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 419947006796 Walker A motif; other site 419947006797 ATP binding site [chemical binding]; other site 419947006798 Walker B motif; other site 419947006799 arginine finger; other site 419947006800 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 419947006801 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 419947006802 putative catalytic cysteine [active] 419947006803 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 419947006804 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 419947006805 dimer interface [polypeptide binding]; other site 419947006806 decamer (pentamer of dimers) interface [polypeptide binding]; other site 419947006807 catalytic triad [active] 419947006808 peroxidatic and resolving cysteines [active] 419947006809 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 419947006810 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 419947006811 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947006812 PPE family; Region: PPE; pfam00823 419947006813 PE family; Region: PE; pfam00934 419947006814 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 419947006815 Mechanosensitive ion channel; Region: MS_channel; pfam00924 419947006816 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 419947006817 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 419947006818 ligand binding site [chemical binding]; other site 419947006819 flexible hinge region; other site 419947006820 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 419947006821 dimerization interface [polypeptide binding]; other site 419947006822 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 419947006823 cyclase homology domain; Region: CHD; cd07302 419947006824 nucleotidyl binding site; other site 419947006825 metal binding site [ion binding]; metal-binding site 419947006826 dimer interface [polypeptide binding]; other site 419947006827 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 419947006828 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 419947006829 substrate binding site [chemical binding]; other site 419947006830 dimer interface [polypeptide binding]; other site 419947006831 ATP binding site [chemical binding]; other site 419947006832 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 419947006833 NAD synthetase; Reviewed; Region: nadE; PRK02628 419947006834 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 419947006835 multimer interface [polypeptide binding]; other site 419947006836 active site 419947006837 catalytic triad [active] 419947006838 protein interface 1 [polypeptide binding]; other site 419947006839 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 419947006840 homodimer interface [polypeptide binding]; other site 419947006841 NAD binding pocket [chemical binding]; other site 419947006842 ATP binding pocket [chemical binding]; other site 419947006843 Mg binding site [ion binding]; other site 419947006844 active-site loop [active] 419947006845 gamma-glutamyl kinase; Provisional; Region: PRK05429 419947006846 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 419947006847 nucleotide binding site [chemical binding]; other site 419947006848 homotetrameric interface [polypeptide binding]; other site 419947006849 putative phosphate binding site [ion binding]; other site 419947006850 putative allosteric binding site; other site 419947006851 PUA domain; Region: PUA; pfam01472 419947006852 GTPase CgtA; Reviewed; Region: obgE; PRK12296 419947006853 GTP1/OBG; Region: GTP1_OBG; pfam01018 419947006854 Obg GTPase; Region: Obg; cd01898 419947006855 G1 box; other site 419947006856 GTP/Mg2+ binding site [chemical binding]; other site 419947006857 Switch I region; other site 419947006858 G2 box; other site 419947006859 G3 box; other site 419947006860 Switch II region; other site 419947006861 G4 box; other site 419947006862 G5 box; other site 419947006863 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 419947006864 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 419947006865 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 419947006866 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 419947006867 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 419947006868 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 419947006869 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 419947006870 homodimer interface [polypeptide binding]; other site 419947006871 oligonucleotide binding site [chemical binding]; other site 419947006872 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 419947006873 active site 419947006874 multimer interface [polypeptide binding]; other site 419947006875 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 419947006876 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 419947006877 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 419947006878 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 419947006879 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 419947006880 active site 419947006881 HIGH motif; other site 419947006882 nucleotide binding site [chemical binding]; other site 419947006883 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 419947006884 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 419947006885 active site 419947006886 KMSKS motif; other site 419947006887 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 419947006888 tRNA binding surface [nucleotide binding]; other site 419947006889 anticodon binding site; other site 419947006890 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 419947006891 Uncharacterized conserved protein [Function unknown]; Region: COG3268 419947006892 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 419947006893 NAD(P) binding pocket [chemical binding]; other site 419947006894 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 419947006895 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 419947006896 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 419947006897 GTP binding site; other site 419947006898 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 419947006899 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 419947006900 TPP-binding site [chemical binding]; other site 419947006901 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 419947006902 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 419947006903 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 419947006904 dimer interface [polypeptide binding]; other site 419947006905 PYR/PP interface [polypeptide binding]; other site 419947006906 TPP binding site [chemical binding]; other site 419947006907 substrate binding site [chemical binding]; other site 419947006908 Major Facilitator Superfamily; Region: MFS_1; pfam07690 419947006909 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 419947006910 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 419947006911 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 419947006912 Walker A motif; other site 419947006913 ATP binding site [chemical binding]; other site 419947006914 Walker B motif; other site 419947006915 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 419947006916 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 419947006917 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 419947006918 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 419947006919 Major Facilitator Superfamily; Region: MFS_1; pfam07690 419947006920 putative substrate translocation pore; other site 419947006921 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 419947006922 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 419947006923 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 419947006924 oligomer interface [polypeptide binding]; other site 419947006925 active site residues [active] 419947006926 Clp protease; Region: CLP_protease; pfam00574 419947006927 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 419947006928 oligomer interface [polypeptide binding]; other site 419947006929 active site residues [active] 419947006930 trigger factor; Provisional; Region: tig; PRK01490 419947006931 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 419947006932 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 419947006933 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 419947006934 Beta-lactamase; Region: Beta-lactamase; pfam00144 419947006935 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 419947006936 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 419947006937 putative DNA binding site [nucleotide binding]; other site 419947006938 catalytic residue [active] 419947006939 putative H2TH interface [polypeptide binding]; other site 419947006940 putative catalytic residues [active] 419947006941 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 419947006942 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 419947006943 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 419947006944 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 419947006945 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 419947006946 Zn binding site [ion binding]; other site 419947006947 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 419947006948 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 419947006949 active site 419947006950 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 419947006951 apolar tunnel; other site 419947006952 heme binding site [chemical binding]; other site 419947006953 dimerization interface [polypeptide binding]; other site 419947006954 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 419947006955 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 419947006956 active site 419947006957 catalytic site [active] 419947006958 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 419947006959 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 419947006960 active site 419947006961 NAD-specific glutamate dehydrogenase [Amino acid transport and metabolism]; Region: COG2902 419947006962 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 419947006963 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 419947006964 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 419947006965 ABC transporter; Region: ABC_tran_2; pfam12848 419947006966 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 419947006967 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 419947006968 dimer interface [polypeptide binding]; other site 419947006969 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 419947006970 ssDNA binding site [nucleotide binding]; other site 419947006971 tetramer (dimer of dimers) interface [polypeptide binding]; other site 419947006972 putative transposase OrfB; Reviewed; Region: PHA02517 419947006973 HTH-like domain; Region: HTH_21; pfam13276 419947006974 Integrase core domain; Region: rve; pfam00665 419947006975 Integrase core domain; Region: rve_3; pfam13683 419947006976 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 419947006977 Transposase; Region: HTH_Tnp_1; cl17663 419947006978 glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355 419947006979 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 419947006980 putative acyl-acceptor binding pocket; other site 419947006981 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 419947006982 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 419947006983 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 419947006984 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 419947006985 putative acyl-acceptor binding pocket; other site 419947006986 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 419947006987 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 419947006988 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 419947006989 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 419947006990 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 419947006991 enoyl-CoA hydratase; Provisional; Region: PRK05870 419947006992 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 419947006993 substrate binding site [chemical binding]; other site 419947006994 oxyanion hole (OAH) forming residues; other site 419947006995 trimer interface [polypeptide binding]; other site 419947006996 PE family; Region: PE; pfam00934 419947006997 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 419947006998 cyclase homology domain; Region: CHD; cd07302 419947006999 nucleotidyl binding site; other site 419947007000 metal binding site [ion binding]; metal-binding site 419947007001 dimer interface [polypeptide binding]; other site 419947007002 Predicted ATPase [General function prediction only]; Region: COG3903 419947007003 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 419947007004 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 419947007005 DNA binding residues [nucleotide binding] 419947007006 dimerization interface [polypeptide binding]; other site 419947007007 PE family; Region: PE; pfam00934 419947007008 TIGR00725 family protein; Region: TIGR00725 419947007009 thymidylate synthase; Provisional; Region: thyA; PRK00956 419947007010 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 419947007011 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 419947007012 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 419947007013 E3 interaction surface; other site 419947007014 lipoyl attachment site [posttranslational modification]; other site 419947007015 e3 binding domain; Region: E3_binding; pfam02817 419947007016 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 419947007017 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 419947007018 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 419947007019 alpha subunit interface [polypeptide binding]; other site 419947007020 TPP binding site [chemical binding]; other site 419947007021 heterodimer interface [polypeptide binding]; other site 419947007022 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 419947007023 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 419947007024 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 419947007025 tetramer interface [polypeptide binding]; other site 419947007026 TPP-binding site [chemical binding]; other site 419947007027 heterodimer interface [polypeptide binding]; other site 419947007028 phosphorylation loop region [posttranslational modification] 419947007029 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 419947007030 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 419947007031 putative active site [active] 419947007032 putative catalytic site [active] 419947007033 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 419947007034 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 419947007035 active site 419947007036 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 419947007037 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 419947007038 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 419947007039 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 419947007040 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 419947007041 carboxyltransferase (CT) interaction site; other site 419947007042 biotinylation site [posttranslational modification]; other site 419947007043 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 419947007044 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 419947007045 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 419947007046 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 419947007047 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 419947007048 AMP-binding domain protein; Validated; Region: PRK08315 419947007049 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 419947007050 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 419947007051 acyl-activating enzyme (AAE) consensus motif; other site 419947007052 acyl-activating enzyme (AAE) consensus motif; other site 419947007053 putative AMP binding site [chemical binding]; other site 419947007054 putative active site [active] 419947007055 putative CoA binding site [chemical binding]; other site 419947007056 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 419947007057 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 419947007058 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 419947007059 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 419947007060 classical (c) SDRs; Region: SDR_c; cd05233 419947007061 NAD(P) binding site [chemical binding]; other site 419947007062 active site 419947007063 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 419947007064 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 419947007065 catalytic site [active] 419947007066 putative active site [active] 419947007067 putative substrate binding site [chemical binding]; other site 419947007068 dimer interface [polypeptide binding]; other site 419947007069 Transposase, Mutator family; Region: Transposase_mut; pfam00872 419947007070 MULE transposase domain; Region: MULE; pfam10551 419947007071 Domain of unknown function (DUF4411); Region: DUF4411; pfam14367 419947007072 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 419947007073 non-specific DNA binding site [nucleotide binding]; other site 419947007074 salt bridge; other site 419947007075 sequence-specific DNA binding site [nucleotide binding]; other site 419947007076 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 419947007077 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893 419947007078 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 419947007079 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 419947007080 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 419947007081 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 419947007082 PE family; Region: PE; pfam00934 419947007083 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 419947007084 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 419947007085 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 419947007086 catalytic triad [active] 419947007087 hypothetical protein; Provisional; Region: PRK07907 419947007088 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 419947007089 active site 419947007090 metal binding site [ion binding]; metal-binding site 419947007091 dimer interface [polypeptide binding]; other site 419947007092 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 419947007093 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 419947007094 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 419947007095 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 419947007096 phosphate binding site [ion binding]; other site 419947007097 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 419947007098 FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447 419947007099 putative active site [active] 419947007100 putative catalytic site [active] 419947007101 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 419947007102 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 419947007103 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 419947007104 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 419947007105 putative NAD(P) binding site [chemical binding]; other site 419947007106 active site 419947007107 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 419947007108 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 419947007109 active site 419947007110 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 419947007111 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 419947007112 putative active site [active] 419947007113 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 419947007114 Mrr N-terminal domain; Region: Mrr_N; pfam14338 419947007115 Restriction endonuclease; Region: Mrr_cat; pfam04471 419947007116 ERCC4 domain; Region: ERCC4; pfam02732 419947007117 Lsr2; Region: Lsr2; pfam11774 419947007118 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 419947007119 putative active site [active] 419947007120 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 419947007121 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 419947007122 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 419947007123 catalytic residue [active] 419947007124 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 419947007125 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 419947007126 putative RNA binding site [nucleotide binding]; other site 419947007127 elongation factor P; Validated; Region: PRK00529 419947007128 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 419947007129 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 419947007130 RNA binding site [nucleotide binding]; other site 419947007131 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 419947007132 RNA binding site [nucleotide binding]; other site 419947007133 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 419947007134 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 419947007135 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 419947007136 active site 419947007137 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 419947007138 Dehydroquinase class II; Region: DHquinase_II; pfam01220 419947007139 trimer interface [polypeptide binding]; other site 419947007140 active site 419947007141 dimer interface [polypeptide binding]; other site 419947007142 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 419947007143 active site 419947007144 dimer interface [polypeptide binding]; other site 419947007145 metal binding site [ion binding]; metal-binding site 419947007146 shikimate kinase; Reviewed; Region: aroK; PRK00131 419947007147 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 419947007148 ADP binding site [chemical binding]; other site 419947007149 magnesium binding site [ion binding]; other site 419947007150 putative shikimate binding site; other site 419947007151 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 419947007152 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 419947007153 Tetramer interface [polypeptide binding]; other site 419947007154 active site 419947007155 FMN-binding site [chemical binding]; other site 419947007156 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 419947007157 digalactosyldiacylglycerol synthase; Region: PLN02846 419947007158 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 419947007159 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 419947007160 putative active site [active] 419947007161 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 419947007162 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 419947007163 oligomeric interface; other site 419947007164 putative active site [active] 419947007165 homodimer interface [polypeptide binding]; other site 419947007166 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402 419947007167 putative active site [active] 419947007168 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 419947007169 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 419947007170 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 419947007171 shikimate-5-dehydrogenase, fungal AROM-type; Region: Shik-DH-AROM; TIGR01809 419947007172 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 419947007173 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 419947007174 NAD(P) binding site [chemical binding]; other site 419947007175 shikimate binding site; other site 419947007176 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 419947007177 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 419947007178 dimerization interface [polypeptide binding]; other site 419947007179 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 419947007180 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 419947007181 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 419947007182 motif 1; other site 419947007183 active site 419947007184 motif 2; other site 419947007185 motif 3; other site 419947007186 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 419947007187 DHHA1 domain; Region: DHHA1; pfam02272 419947007188 Uncharacterized conserved protein [Function unknown]; Region: COG0432 419947007189 recombination factor protein RarA; Reviewed; Region: PRK13342 419947007190 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 419947007191 Walker A motif; other site 419947007192 ATP binding site [chemical binding]; other site 419947007193 Walker B motif; other site 419947007194 arginine finger; other site 419947007195 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 419947007196 Predicted integral membrane protein [Function unknown]; Region: COG5473 419947007197 Protein of unknown function (DUF2652); Region: DUF2652; pfam10851 419947007198 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 419947007199 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 419947007200 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 419947007201 Walker A/P-loop; other site 419947007202 ATP binding site [chemical binding]; other site 419947007203 Q-loop/lid; other site 419947007204 ABC transporter signature motif; other site 419947007205 Walker B; other site 419947007206 D-loop; other site 419947007207 H-loop/switch region; other site 419947007208 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 419947007209 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 419947007210 ligand binding site [chemical binding]; other site 419947007211 flexible hinge region; other site 419947007212 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 419947007213 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 419947007214 ligand binding site [chemical binding]; other site 419947007215 flexible hinge region; other site 419947007216 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 419947007217 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 419947007218 active site 419947007219 nucleophile elbow; other site 419947007220 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 419947007221 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 419947007222 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 419947007223 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 419947007224 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 419947007225 Uncharacterized conserved protein [Function unknown]; Region: COG2308 419947007226 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 419947007227 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 419947007228 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 419947007229 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 419947007230 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 419947007231 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 419947007232 Transglutaminase/protease-like homologues; Region: TGc; smart00460 419947007233 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3801 419947007234 Predicted membrane protein [Function unknown]; Region: COG4129 419947007235 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 419947007236 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 419947007237 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 419947007238 dimer interface [polypeptide binding]; other site 419947007239 anticodon binding site; other site 419947007240 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 419947007241 homodimer interface [polypeptide binding]; other site 419947007242 motif 1; other site 419947007243 active site 419947007244 motif 2; other site 419947007245 GAD domain; Region: GAD; pfam02938 419947007246 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 419947007247 active site 419947007248 motif 3; other site 419947007249 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 419947007250 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 419947007251 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 419947007252 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 419947007253 putative hydrophobic ligand binding site [chemical binding]; other site 419947007254 protein interface [polypeptide binding]; other site 419947007255 gate; other site 419947007256 Predicted metalloprotease [General function prediction only]; Region: COG2321 419947007257 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 419947007258 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 419947007259 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 419947007260 active site 419947007261 metal binding site [ion binding]; metal-binding site 419947007262 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 419947007263 haloalkane dehalogenase; Provisional; Region: PRK03592 419947007264 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 419947007265 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 419947007266 dimer interface [polypeptide binding]; other site 419947007267 motif 1; other site 419947007268 active site 419947007269 motif 2; other site 419947007270 motif 3; other site 419947007271 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 419947007272 anticodon binding site; other site 419947007273 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 419947007274 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 419947007275 active site 419947007276 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 419947007277 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 419947007278 Zn2+ binding site [ion binding]; other site 419947007279 Mg2+ binding site [ion binding]; other site 419947007280 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 419947007281 synthetase active site [active] 419947007282 NTP binding site [chemical binding]; other site 419947007283 metal binding site [ion binding]; metal-binding site 419947007284 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 419947007285 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 419947007286 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 419947007287 active site 419947007288 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 419947007289 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 419947007290 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 419947007291 Protein export membrane protein; Region: SecD_SecF; pfam02355 419947007292 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 419947007293 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 419947007294 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05886 419947007295 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 419947007296 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 419947007297 inhibitor-cofactor binding pocket; inhibition site 419947007298 pyridoxal 5'-phosphate binding site [chemical binding]; other site 419947007299 catalytic residue [active] 419947007300 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 419947007301 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 419947007302 acyl-activating enzyme (AAE) consensus motif; other site 419947007303 AMP binding site [chemical binding]; other site 419947007304 active site 419947007305 CoA binding site [chemical binding]; other site 419947007306 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 419947007307 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 419947007308 putative NAD(P) binding site [chemical binding]; other site 419947007309 active site 419947007310 putative substrate binding site [chemical binding]; other site 419947007311 PE family; Region: PE; pfam00934 419947007312 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 419947007313 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 419947007314 Walker A motif; other site 419947007315 ATP binding site [chemical binding]; other site 419947007316 Walker B motif; other site 419947007317 arginine finger; other site 419947007318 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 419947007319 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 419947007320 RuvA N terminal domain; Region: RuvA_N; pfam01330 419947007321 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 419947007322 active site 419947007323 putative DNA-binding cleft [nucleotide binding]; other site 419947007324 dimer interface [polypeptide binding]; other site 419947007325 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 419947007326 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 419947007327 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 419947007328 putative active site [active] 419947007329 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 419947007330 Protein of unknown function DUF2617; Region: DUF2617; pfam10936 419947007331 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 419947007332 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 419947007333 Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only]; Region: COG4262 419947007334 Spermine/spermidine synthase; Region: Spermine_synth; pfam01564 419947007335 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 419947007336 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 419947007337 hypothetical protein; Validated; Region: PRK00110 419947007338 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 419947007339 predicted active site [active] 419947007340 catalytic triad [active] 419947007341 acyl-CoA thioesterase II; Region: tesB; TIGR00189 419947007342 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 419947007343 active site 419947007344 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 419947007345 catalytic triad [active] 419947007346 dimer interface [polypeptide binding]; other site 419947007347 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 419947007348 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 419947007349 active site 419947007350 multimer interface [polypeptide binding]; other site 419947007351 Pyridoxamine-phosphate oxidase [Coenzyme metabolism]; Region: PdxH; COG0259 419947007352 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 419947007353 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 419947007354 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947007355 PPE family; Region: PPE; pfam00823 419947007356 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947007357 PE-PPE domain; Region: PE-PPE; pfam08237 419947007358 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 419947007359 nudix motif; other site 419947007360 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 419947007361 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 419947007362 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 419947007363 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 419947007364 putative acyl-acceptor binding pocket; other site 419947007365 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 419947007366 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 419947007367 nucleotide binding site/active site [active] 419947007368 HIT family signature motif; other site 419947007369 catalytic residue [active] 419947007370 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 419947007371 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 419947007372 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 419947007373 active site 419947007374 dimer interface [polypeptide binding]; other site 419947007375 motif 1; other site 419947007376 motif 2; other site 419947007377 motif 3; other site 419947007378 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 419947007379 anticodon binding site; other site 419947007380 PE family; Region: PE; pfam00934 419947007381 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4762 419947007382 Predicted transcriptional regulator [Transcription]; Region: COG2345 419947007383 Helix-turn-helix domain; Region: HTH_20; pfam12840 419947007384 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 419947007385 Predicted transcriptional regulator [Transcription]; Region: COG2345 419947007386 Helix-turn-helix domain; Region: HTH_20; pfam12840 419947007387 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 419947007388 S-adenosylmethionine binding site [chemical binding]; other site 419947007389 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 419947007390 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 419947007391 Ligand Binding Site [chemical binding]; other site 419947007392 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 419947007393 Ligand Binding Site [chemical binding]; other site 419947007394 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 419947007395 Ligand Binding Site [chemical binding]; other site 419947007396 Universal stress protein family; Region: Usp; pfam00582 419947007397 Ligand Binding Site [chemical binding]; other site 419947007398 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 419947007399 active site 419947007400 Peptidase family M50; Region: Peptidase_M50; pfam02163 419947007401 putative substrate binding region [chemical binding]; other site 419947007402 FOG: CBS domain [General function prediction only]; Region: COG0517 419947007403 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 419947007404 FOG: CBS domain [General function prediction only]; Region: COG0517 419947007405 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 419947007406 peptide chain release factor 1; Provisional; Region: PRK04011 419947007407 SHS2 domain protein implicated in nucleic acid metabolism [General function prediction only]; Region: COG1371 419947007408 Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690 419947007409 hypothetical protein; Reviewed; Region: PRK09588 419947007410 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 419947007411 Hemerythrin-like domain; Region: Hr-like; cd12108 419947007412 Fe binding site [ion binding]; other site 419947007413 PE family; Region: PE; pfam00934 419947007414 Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cd00227 419947007415 P-loop motif; other site 419947007416 ATP binding site [chemical binding]; other site 419947007417 Chloramphenicol (Cm) binding site [chemical binding]; other site 419947007418 catalytic residue [active] 419947007419 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 419947007420 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 419947007421 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 419947007422 anti sigma factor interaction site; other site 419947007423 regulatory phosphorylation site [posttranslational modification]; other site 419947007424 hypothetical protein; Provisional; Region: PRK02237 419947007425 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 419947007426 Transcriptional regulators [Transcription]; Region: MarR; COG1846 419947007427 putative DNA binding site [nucleotide binding]; other site 419947007428 putative Zn2+ binding site [ion binding]; other site 419947007429 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 419947007430 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 419947007431 putative metal binding site [ion binding]; other site 419947007432 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 419947007433 dimerization interface [polypeptide binding]; other site 419947007434 putative DNA binding site [nucleotide binding]; other site 419947007435 putative Zn2+ binding site [ion binding]; other site 419947007436 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 419947007437 arsenical-resistance protein; Region: acr3; TIGR00832 419947007438 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 419947007439 Low molecular weight phosphatase family; Region: LMWPc; cd00115 419947007440 active site 419947007441 Protein of unknown function (DUF3018); Region: DUF3018; pfam11455 419947007442 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 419947007443 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 419947007444 active site 419947007445 DNA binding site [nucleotide binding] 419947007446 Int/Topo IB signature motif; other site 419947007447 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 419947007448 Transposase; Region: HTH_Tnp_1; cl17663 419947007449 putative transposase OrfB; Reviewed; Region: PHA02517 419947007450 HTH-like domain; Region: HTH_21; pfam13276 419947007451 Integrase core domain; Region: rve; pfam00665 419947007452 Integrase core domain; Region: rve_3; pfam13683 419947007453 Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653 419947007454 Phage capsid family; Region: Phage_capsid; pfam05065 419947007455 Phage head maturation protease [General function prediction only]; Region: COG3740 419947007456 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: COG3747 419947007457 Protein of unknown function (DUF3631); Region: DUF3631; pfam12307 419947007458 Protein of unknown function (DUF2742); Region: DUF2742; pfam10888 419947007459 DNA binding domain, excisionase family; Region: excise; TIGR01764 419947007460 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 419947007461 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 419947007462 active site 419947007463 catalytic residues [active] 419947007464 DNA binding site [nucleotide binding] 419947007465 Int/Topo IB signature motif; other site 419947007466 Transposase, Mutator family; Region: Transposase_mut; pfam00872 419947007467 MULE transposase domain; Region: MULE; pfam10551 419947007468 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 419947007469 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 419947007470 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 419947007471 Coenzyme A binding pocket [chemical binding]; other site 419947007472 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 419947007473 hypothetical protein; Provisional; Region: PRK14059 419947007474 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 419947007475 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 419947007476 TAP-like protein; Region: Abhydrolase_4; pfam08386 419947007477 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 419947007478 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 419947007479 SelR domain; Region: SelR; pfam01641 419947007480 Methyltransferase domain; Region: Methyltransf_31; pfam13847 419947007481 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 419947007482 S-adenosylmethionine binding site [chemical binding]; other site 419947007483 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 419947007484 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 419947007485 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 419947007486 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 419947007487 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 419947007488 substrate binding site [chemical binding]; other site 419947007489 active site 419947007490 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 419947007491 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 419947007492 substrate binding site [chemical binding]; other site 419947007493 oxyanion hole (OAH) forming residues; other site 419947007494 trimer interface [polypeptide binding]; other site 419947007495 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 419947007496 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 419947007497 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 419947007498 catalytic site [active] 419947007499 putative active site [active] 419947007500 putative substrate binding site [chemical binding]; other site 419947007501 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 419947007502 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 419947007503 TPP-binding site; other site 419947007504 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 419947007505 PYR/PP interface [polypeptide binding]; other site 419947007506 dimer interface [polypeptide binding]; other site 419947007507 TPP binding site [chemical binding]; other site 419947007508 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 419947007509 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 419947007510 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 419947007511 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 419947007512 transmembrane helices; other site 419947007513 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 419947007514 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 419947007515 transmembrane helices; other site 419947007516 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 419947007517 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 419947007518 Walker A/P-loop; other site 419947007519 ATP binding site [chemical binding]; other site 419947007520 Q-loop/lid; other site 419947007521 ABC transporter signature motif; other site 419947007522 Walker B; other site 419947007523 D-loop; other site 419947007524 H-loop/switch region; other site 419947007525 TRAM domain; Region: TRAM; cl01282 419947007526 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 419947007527 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 419947007528 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 419947007529 TrkA-N domain; Region: TrkA_N; pfam02254 419947007530 TrkA-C domain; Region: TrkA_C; pfam02080 419947007531 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 419947007532 TrkA-N domain; Region: TrkA_N; pfam02254 419947007533 TrkA-C domain; Region: TrkA_C; pfam02080 419947007534 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 419947007535 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 419947007536 generic binding surface II; other site 419947007537 ssDNA binding site; other site 419947007538 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 419947007539 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 419947007540 trimer interface [polypeptide binding]; other site 419947007541 active site 419947007542 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 419947007543 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 419947007544 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 419947007545 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 419947007546 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 419947007547 active site 419947007548 dimerization interface [polypeptide binding]; other site 419947007549 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 419947007550 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 419947007551 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 419947007552 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 419947007553 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 419947007554 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 419947007555 DNA binding residues [nucleotide binding] 419947007556 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 419947007557 homotrimer interaction site [polypeptide binding]; other site 419947007558 putative active site [active] 419947007559 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502 419947007560 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 419947007561 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 419947007562 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 419947007563 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 419947007564 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 419947007565 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 419947007566 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 419947007567 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 419947007568 DNA binding residues [nucleotide binding] 419947007569 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 419947007570 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 419947007571 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 419947007572 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 419947007573 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 419947007574 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 419947007575 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 419947007576 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 419947007577 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 419947007578 PAC2 family; Region: PAC2; pfam09754 419947007579 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 419947007580 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 419947007581 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 419947007582 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 419947007583 heme-binding site [chemical binding]; other site 419947007584 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 419947007585 ATP cone domain; Region: ATP-cone; pfam03477 419947007586 LysM domain; Region: LysM; pfam01476 419947007587 LexA repressor; Validated; Region: PRK00215 419947007588 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 419947007589 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 419947007590 Catalytic site [active] 419947007591 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 419947007592 LGFP repeat; Region: LGFP; pfam08310 419947007593 LGFP repeat; Region: LGFP; pfam08310 419947007594 LGFP repeat; Region: LGFP; pfam08310 419947007595 LGFP repeat; Region: LGFP; pfam08310 419947007596 LGFP repeat; Region: LGFP; pfam08310 419947007597 Integral membrane protein TerC family; Region: TerC; cl10468 419947007598 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 419947007599 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 419947007600 active site 419947007601 GTPases [General function prediction only]; Region: HflX; COG2262 419947007602 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 419947007603 HflX GTPase family; Region: HflX; cd01878 419947007604 G1 box; other site 419947007605 GTP/Mg2+ binding site [chemical binding]; other site 419947007606 Switch I region; other site 419947007607 G2 box; other site 419947007608 G3 box; other site 419947007609 Switch II region; other site 419947007610 G4 box; other site 419947007611 G5 box; other site 419947007612 diaminopimelate epimerase; Region: DapF; TIGR00652 419947007613 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 419947007614 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 419947007615 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 419947007616 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 419947007617 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 419947007618 active site 419947007619 metal binding site [ion binding]; metal-binding site 419947007620 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 419947007621 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 419947007622 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 419947007623 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 419947007624 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 419947007625 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 419947007626 FeS/SAM binding site; other site 419947007627 TRAM domain; Region: TRAM; cl01282 419947007628 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 419947007629 FeS/SAM binding site; other site 419947007630 Uncharacterized protein conserved in bacteria [General function prediction only]; Region: OraA; COG2137 419947007631 DNA recombination protein RecA; Reviewed; Region: recA; PRK09519 419947007632 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 419947007633 hexamer interface [polypeptide binding]; other site 419947007634 Walker A motif; other site 419947007635 ATP binding site [chemical binding]; other site 419947007636 Walker B motif; other site 419947007637 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 419947007638 protein-splicing catalytic site; other site 419947007639 thioester formation/cholesterol transfer; other site 419947007640 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 419947007641 recA bacterial DNA recombination protein; Region: RecA; cl17211 419947007642 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 419947007643 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 419947007644 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 419947007645 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 419947007646 Limonene-1,2-epoxide hydrolase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LimA; COG4308 419947007647 PE family; Region: PE; pfam00934 419947007648 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 419947007649 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 419947007650 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 419947007651 non-specific DNA binding site [nucleotide binding]; other site 419947007652 salt bridge; other site 419947007653 sequence-specific DNA binding site [nucleotide binding]; other site 419947007654 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 419947007655 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 419947007656 Coenzyme A binding pocket [chemical binding]; other site 419947007657 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 419947007658 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 419947007659 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 419947007660 Uncharacterized conserved protein [Function unknown]; Region: COG1359 419947007661 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 419947007662 classical (c) SDRs; Region: SDR_c; cd05233 419947007663 NAD(P) binding site [chemical binding]; other site 419947007664 active site 419947007665 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 419947007666 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 419947007667 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 419947007668 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 419947007669 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 419947007670 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 419947007671 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 419947007672 dimer interface [polypeptide binding]; other site 419947007673 active site 419947007674 catalytic residue [active] 419947007675 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 419947007676 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 419947007677 HsdM N-terminal domain; Region: HsdM_N; pfam12161 419947007678 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 419947007679 Methyltransferase domain; Region: Methyltransf_26; pfam13659 419947007680 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 419947007681 putative active site [active] 419947007682 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 419947007683 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 419947007684 putative active site [active] 419947007685 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 419947007686 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 419947007687 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 419947007688 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 419947007689 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 419947007690 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 419947007691 folate binding site [chemical binding]; other site 419947007692 NADP+ binding site [chemical binding]; other site 419947007693 thymidylate synthase; Reviewed; Region: thyA; PRK01827 419947007694 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 419947007695 dimerization interface [polypeptide binding]; other site 419947007696 active site 419947007697 Dienelactone hydrolase family; Region: DLH; pfam01738 419947007698 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 419947007699 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 419947007700 classical (c) SDRs; Region: SDR_c; cd05233 419947007701 NAD(P) binding site [chemical binding]; other site 419947007702 active site 419947007703 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947007704 PPE family; Region: PPE; pfam00823 419947007705 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 419947007706 PE family; Region: PE; pfam00934 419947007707 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 419947007708 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947007709 PPE family; Region: PPE; pfam00823 419947007710 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 419947007711 dihydrodipicolinate reductase; Provisional; Region: PRK00048 419947007712 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 419947007713 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 419947007714 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 419947007715 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 419947007716 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 419947007717 Coenzyme A binding pocket [chemical binding]; other site 419947007718 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 419947007719 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 419947007720 FMN-binding pocket [chemical binding]; other site 419947007721 flavin binding motif; other site 419947007722 phosphate binding motif [ion binding]; other site 419947007723 beta-alpha-beta structure motif; other site 419947007724 NAD binding pocket [chemical binding]; other site 419947007725 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 419947007726 catalytic loop [active] 419947007727 iron binding site [ion binding]; other site 419947007728 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 419947007729 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 419947007730 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 419947007731 hydrophobic ligand binding site; other site 419947007732 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 419947007733 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 419947007734 putative DNA binding site [nucleotide binding]; other site 419947007735 putative Zn2+ binding site [ion binding]; other site 419947007736 AsnC family; Region: AsnC_trans_reg; pfam01037 419947007737 alanine dehydrogenase; Region: alaDH; TIGR00518 419947007738 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 419947007739 hexamer interface [polypeptide binding]; other site 419947007740 ligand binding site [chemical binding]; other site 419947007741 putative active site [active] 419947007742 NAD(P) binding site [chemical binding]; other site 419947007743 Nitronate monooxygenase; Region: NMO; pfam03060 419947007744 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 419947007745 FMN binding site [chemical binding]; other site 419947007746 substrate binding site [chemical binding]; other site 419947007747 putative catalytic residue [active] 419947007748 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 419947007749 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 419947007750 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 419947007751 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 419947007752 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 419947007753 oligomer interface [polypeptide binding]; other site 419947007754 RNA binding site [nucleotide binding]; other site 419947007755 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 419947007756 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 419947007757 RNase E interface [polypeptide binding]; other site 419947007758 trimer interface [polypeptide binding]; other site 419947007759 active site 419947007760 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 419947007761 putative nucleic acid binding region [nucleotide binding]; other site 419947007762 G-X-X-G motif; other site 419947007763 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 419947007764 RNA binding site [nucleotide binding]; other site 419947007765 domain interface; other site 419947007766 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 419947007767 16S/18S rRNA binding site [nucleotide binding]; other site 419947007768 S13e-L30e interaction site [polypeptide binding]; other site 419947007769 25S rRNA binding site [nucleotide binding]; other site 419947007770 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 419947007771 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 419947007772 active site 419947007773 Riboflavin kinase; Region: Flavokinase; pfam01687 419947007774 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 419947007775 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 419947007776 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 419947007777 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 419947007778 putative DNA binding site [nucleotide binding]; other site 419947007779 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 419947007780 FeoA domain; Region: FeoA; pfam04023 419947007781 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 419947007782 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 419947007783 active site 419947007784 lipid-transfer protein; Provisional; Region: PRK08256 419947007785 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 419947007786 active site 419947007787 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 419947007788 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 419947007789 Probable transposase; Region: OrfB_IS605; pfam01385 419947007790 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 419947007791 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 419947007792 catalytic residues [active] 419947007793 catalytic nucleophile [active] 419947007794 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 419947007795 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 419947007796 RNA binding site [nucleotide binding]; other site 419947007797 active site 419947007798 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 419947007799 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 419947007800 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 419947007801 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 419947007802 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 419947007803 active site 419947007804 metal binding site [ion binding]; metal-binding site 419947007805 Uncharacterized conserved protein [Function unknown]; Region: COG4717 419947007806 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 419947007807 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 419947007808 Predicted acyl esterases [General function prediction only]; Region: COG2936 419947007809 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 419947007810 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 419947007811 Uncharacterized conserved protein [Function unknown]; Region: COG5586 419947007812 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 419947007813 Integrase core domain; Region: rve; pfam00665 419947007814 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 419947007815 Transposase; Region: DDE_Tnp_ISL3; pfam01610 419947007816 Helix-turn-helix domain; Region: HTH_28; pfam13518 419947007817 Winged helix-turn helix; Region: HTH_29; pfam13551 419947007818 Integrase core domain; Region: rve; pfam00665 419947007819 Integrase core domain; Region: rve_3; pfam13683 419947007820 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 419947007821 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 419947007822 putative transposase OrfB; Reviewed; Region: PHA02517 419947007823 HTH-like domain; Region: HTH_21; pfam13276 419947007824 Integrase core domain; Region: rve; pfam00665 419947007825 Integrase core domain; Region: rve_3; pfam13683 419947007826 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 419947007827 Transposase; Region: HTH_Tnp_1; cl17663 419947007828 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 419947007829 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09636 419947007830 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cd09699 419947007831 CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cd09662 419947007832 CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cd09663 419947007833 CRISPR/Cas system-associated RAMP superfamily protein Csm3; Region: Csm3_III-A; cd09684 419947007834 CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cd09647 419947007835 Predicted CRISPR-associated polymerase [Defense mechanisms]; Region: COG1353 419947007836 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 419947007837 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 419947007838 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4293 419947007839 Uncharacterized conserved protein [Function unknown]; Region: COG2253 419947007840 Protein of unknown function (DUF2005); Region: DUF2005; pfam09407 419947007841 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4293 419947007842 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 419947007843 enoyl-CoA hydratase; Provisional; Region: PRK06190 419947007844 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 419947007845 substrate binding site [chemical binding]; other site 419947007846 oxyanion hole (OAH) forming residues; other site 419947007847 trimer interface [polypeptide binding]; other site 419947007848 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 419947007849 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 419947007850 Walker A/P-loop; other site 419947007851 ATP binding site [chemical binding]; other site 419947007852 Q-loop/lid; other site 419947007853 ABC transporter signature motif; other site 419947007854 Walker B; other site 419947007855 D-loop; other site 419947007856 H-loop/switch region; other site 419947007857 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 419947007858 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 419947007859 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 419947007860 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 419947007861 dimer interface [polypeptide binding]; other site 419947007862 conserved gate region; other site 419947007863 putative PBP binding loops; other site 419947007864 ABC-ATPase subunit interface; other site 419947007865 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 419947007866 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 419947007867 dimer interface [polypeptide binding]; other site 419947007868 conserved gate region; other site 419947007869 putative PBP binding loops; other site 419947007870 ABC-ATPase subunit interface; other site 419947007871 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 419947007872 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 419947007873 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 419947007874 DHH family; Region: DHH; pfam01368 419947007875 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 419947007876 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 419947007877 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 419947007878 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 419947007879 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 419947007880 G1 box; other site 419947007881 putative GEF interaction site [polypeptide binding]; other site 419947007882 GTP/Mg2+ binding site [chemical binding]; other site 419947007883 Switch I region; other site 419947007884 G2 box; other site 419947007885 G3 box; other site 419947007886 Switch II region; other site 419947007887 G4 box; other site 419947007888 G5 box; other site 419947007889 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 419947007890 Translation-initiation factor 2; Region: IF-2; pfam11987 419947007891 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 419947007892 Predicted nucleic-acid-binding protein implicated in transcription termination [Transcription]; Region: COG2740 419947007893 putative RNA binding cleft [nucleotide binding]; other site 419947007894 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 419947007895 NusA N-terminal domain; Region: NusA_N; pfam08529 419947007896 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 419947007897 RNA binding site [nucleotide binding]; other site 419947007898 homodimer interface [polypeptide binding]; other site 419947007899 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 419947007900 G-X-X-G motif; other site 419947007901 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 419947007902 G-X-X-G motif; other site 419947007903 ribosome maturation protein RimP; Reviewed; Region: PRK00092 419947007904 Sm and related proteins; Region: Sm_like; cl00259 419947007905 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 419947007906 putative oligomer interface [polypeptide binding]; other site 419947007907 putative RNA binding site [nucleotide binding]; other site 419947007908 Mitochondrial ATP synthase g subunit; Region: ATP-synt_G; pfam04718 419947007909 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 419947007910 dinuclear metal binding motif [ion binding]; other site 419947007911 prolyl-tRNA synthetase; Provisional; Region: PRK09194 419947007912 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 419947007913 dimer interface [polypeptide binding]; other site 419947007914 motif 1; other site 419947007915 active site 419947007916 motif 2; other site 419947007917 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 419947007918 putative deacylase active site [active] 419947007919 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 419947007920 active site 419947007921 motif 3; other site 419947007922 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 419947007923 anticodon binding site; other site 419947007924 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 419947007925 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 419947007926 putative substrate translocation pore; other site 419947007927 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 419947007928 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 419947007929 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 419947007930 homodimer interface [polypeptide binding]; other site 419947007931 active site 419947007932 SAM binding site [chemical binding]; other site 419947007933 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 419947007934 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 419947007935 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 419947007936 catalytic triad [active] 419947007937 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 419947007938 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 419947007939 homodimer interface [polypeptide binding]; other site 419947007940 Walker A motif; other site 419947007941 ATP binding site [chemical binding]; other site 419947007942 hydroxycobalamin binding site [chemical binding]; other site 419947007943 Walker B motif; other site 419947007944 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 419947007945 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 419947007946 Walker A motif; other site 419947007947 ATP binding site [chemical binding]; other site 419947007948 Walker B motif; other site 419947007949 arginine finger; other site 419947007950 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 419947007951 metal ion-dependent adhesion site (MIDAS); other site 419947007952 Predicted acyltransferase [General function prediction only]; Region: ElaA; COG2153 419947007953 malate:quinone oxidoreductase; Validated; Region: PRK05257 419947007954 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 419947007955 PE family; Region: PE; pfam00934 419947007956 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 419947007957 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 419947007958 mycothione reductase; Reviewed; Region: PRK07846 419947007959 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 419947007960 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 419947007961 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 419947007962 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 419947007963 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 419947007964 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 419947007965 short chain dehydrogenase; Provisional; Region: PRK06057 419947007966 classical (c) SDRs; Region: SDR_c; cd05233 419947007967 NAD(P) binding site [chemical binding]; other site 419947007968 active site 419947007969 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 419947007970 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 419947007971 NAD(P) binding site [chemical binding]; other site 419947007972 catalytic residues [active] 419947007973 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 419947007974 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 419947007975 catalytic triad [active] 419947007976 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 419947007977 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 419947007978 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 419947007979 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 419947007980 active site 419947007981 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 419947007982 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 419947007983 putative active site [active] 419947007984 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 419947007985 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 419947007986 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 419947007987 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 419947007988 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 419947007989 Predicted acetyltransferase [General function prediction only]; Region: COG3393 419947007990 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 419947007991 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 419947007992 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 419947007993 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 419947007994 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 419947007995 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 419947007996 active site 419947007997 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 419947007998 protein binding site [polypeptide binding]; other site 419947007999 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 419947008000 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 419947008001 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 419947008002 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 419947008003 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 419947008004 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 419947008005 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 419947008006 Fasciclin domain; Region: Fasciclin; pfam02469 419947008007 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 419947008008 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 419947008009 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 419947008010 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 419947008011 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 419947008012 catalytic residues [active] 419947008013 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 419947008014 Fasciclin domain; Region: Fasciclin; pfam02469 419947008015 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 419947008016 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 419947008017 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 419947008018 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 419947008019 catalytic residues [active] 419947008020 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 419947008021 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 419947008022 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 419947008023 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 419947008024 ribosome recycling factor; Reviewed; Region: frr; PRK00083 419947008025 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 419947008026 hinge region; other site 419947008027 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 419947008028 putative nucleotide binding site [chemical binding]; other site 419947008029 uridine monophosphate binding site [chemical binding]; other site 419947008030 homohexameric interface [polypeptide binding]; other site 419947008031 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 419947008032 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 419947008033 DNA binding site [nucleotide binding] 419947008034 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 419947008035 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 419947008036 Probable transposase; Region: OrfB_IS605; pfam01385 419947008037 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 419947008038 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 419947008039 catalytic residues [active] 419947008040 catalytic nucleophile [active] 419947008041 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 419947008042 MarR family; Region: MarR; pfam01047 419947008043 amidase; Provisional; Region: PRK07869 419947008044 Amidase; Region: Amidase; pfam01425 419947008045 elongation factor Ts; Provisional; Region: tsf; PRK09377 419947008046 UBA/TS-N domain; Region: UBA; pfam00627 419947008047 Elongation factor TS; Region: EF_TS; pfam00889 419947008048 Elongation factor TS; Region: EF_TS; pfam00889 419947008049 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 419947008050 rRNA interaction site [nucleotide binding]; other site 419947008051 S8 interaction site; other site 419947008052 putative laminin-1 binding site; other site 419947008053 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 419947008054 Peptidase family M23; Region: Peptidase_M23; pfam01551 419947008055 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947008056 PPE family; Region: PPE; pfam00823 419947008057 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 419947008058 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 419947008059 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 419947008060 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 419947008061 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 419947008062 active site 419947008063 DNA binding site [nucleotide binding] 419947008064 Int/Topo IB signature motif; other site 419947008065 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 419947008066 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 419947008067 FAD binding pocket [chemical binding]; other site 419947008068 FAD binding motif [chemical binding]; other site 419947008069 phosphate binding motif [ion binding]; other site 419947008070 NAD binding pocket [chemical binding]; other site 419947008071 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 419947008072 DNA protecting protein DprA; Region: dprA; TIGR00732 419947008073 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 419947008074 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 419947008075 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 419947008076 Walker A motif; other site 419947008077 ATP binding site [chemical binding]; other site 419947008078 Walker B motif; other site 419947008079 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 419947008080 hypothetical protein; Reviewed; Region: PRK12497 419947008081 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 419947008082 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 419947008083 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 419947008084 putative molybdopterin cofactor binding site [chemical binding]; other site 419947008085 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 419947008086 putative molybdopterin cofactor binding site; other site 419947008087 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 419947008088 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 419947008089 RNA/DNA hybrid binding site [nucleotide binding]; other site 419947008090 active site 419947008091 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 419947008092 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 419947008093 Catalytic site [active] 419947008094 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 419947008095 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 419947008096 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 419947008097 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 419947008098 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 419947008099 RimM N-terminal domain; Region: RimM; pfam01782 419947008100 hypothetical protein; Provisional; Region: PRK02821 419947008101 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 419947008102 G-X-X-G motif; other site 419947008103 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 419947008104 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 419947008105 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 419947008106 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 419947008107 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 419947008108 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 419947008109 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 419947008110 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 419947008111 active site 419947008112 putative substrate binding pocket [chemical binding]; other site 419947008113 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 419947008114 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 419947008115 Catalytic domain of Protein Kinases; Region: PKc; cd00180 419947008116 active site 419947008117 ATP binding site [chemical binding]; other site 419947008118 substrate binding site [chemical binding]; other site 419947008119 activation loop (A-loop); other site 419947008120 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 419947008121 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 419947008122 active site 419947008123 signal recognition particle protein; Provisional; Region: PRK10867 419947008124 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 419947008125 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 419947008126 P loop; other site 419947008127 GTP binding site [chemical binding]; other site 419947008128 Signal peptide binding domain; Region: SRP_SPB; pfam02978 419947008129 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 419947008130 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 419947008131 ATP binding site [chemical binding]; other site 419947008132 putative Mg++ binding site [ion binding]; other site 419947008133 PII uridylyl-transferase; Provisional; Region: PRK03381 419947008134 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 419947008135 metal binding triad; other site 419947008136 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 419947008137 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 419947008138 Zn2+ binding site [ion binding]; other site 419947008139 Mg2+ binding site [ion binding]; other site 419947008140 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 419947008141 Nitrogen regulatory protein P-II; Region: P-II; smart00938 419947008142 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 419947008143 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 419947008144 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 419947008145 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 419947008146 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 419947008147 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 419947008148 Walker A/P-loop; other site 419947008149 ATP binding site [chemical binding]; other site 419947008150 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 419947008151 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 419947008152 ABC transporter signature motif; other site 419947008153 Walker B; other site 419947008154 D-loop; other site 419947008155 H-loop/switch region; other site 419947008156 acylphosphatase; Provisional; Region: PRK14422 419947008157 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 419947008158 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 419947008159 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 419947008160 DNA binding site [nucleotide binding] 419947008161 catalytic residue [active] 419947008162 H2TH interface [polypeptide binding]; other site 419947008163 putative catalytic residues [active] 419947008164 turnover-facilitating residue; other site 419947008165 intercalation triad [nucleotide binding]; other site 419947008166 8OG recognition residue [nucleotide binding]; other site 419947008167 putative reading head residues; other site 419947008168 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 419947008169 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 419947008170 ribonuclease III; Reviewed; Region: rnc; PRK00102 419947008171 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 419947008172 dimerization interface [polypeptide binding]; other site 419947008173 active site 419947008174 metal binding site [ion binding]; metal-binding site 419947008175 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 419947008176 dsRNA binding site [nucleotide binding]; other site 419947008177 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 419947008178 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 419947008179 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 419947008180 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 419947008181 acyl-CoA synthetase; Validated; Region: PRK05850 419947008182 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 419947008183 acyl-activating enzyme (AAE) consensus motif; other site 419947008184 active site 419947008185 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 419947008186 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 419947008187 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 419947008188 active site 419947008189 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 419947008190 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 419947008191 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 419947008192 NADP binding site [chemical binding]; other site 419947008193 KR domain; Region: KR; pfam08659 419947008194 active site 419947008195 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 419947008196 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 419947008197 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 419947008198 active site 419947008199 Acyl transferase domain; Region: Acyl_transf_1; cl08282 419947008200 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 419947008201 KR domain; Region: KR; pfam08659 419947008202 NADP binding site [chemical binding]; other site 419947008203 active site 419947008204 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 419947008205 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 419947008206 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 419947008207 active site 419947008208 Acyl transferase domain; Region: Acyl_transf_1; cl08282 419947008209 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 419947008210 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 419947008211 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 419947008212 Enoylreductase; Region: PKS_ER; smart00829 419947008213 NAD(P) binding site [chemical binding]; other site 419947008214 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 419947008215 KR domain; Region: KR; pfam08659 419947008216 putative NADP binding site [chemical binding]; other site 419947008217 active site 419947008218 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 419947008219 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 419947008220 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 419947008221 active site 419947008222 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 419947008223 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 419947008224 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 419947008225 KR domain; Region: KR; pfam08659 419947008226 putative NADP binding site [chemical binding]; other site 419947008227 active site 419947008228 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 419947008229 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 419947008230 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 419947008231 active site 419947008232 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 419947008233 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 419947008234 Condensation domain; Region: Condensation; pfam00668 419947008235 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 419947008236 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 419947008237 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 419947008238 Walker A/P-loop; other site 419947008239 ATP binding site [chemical binding]; other site 419947008240 Q-loop/lid; other site 419947008241 ABC transporter signature motif; other site 419947008242 Walker B; other site 419947008243 D-loop; other site 419947008244 H-loop/switch region; other site 419947008245 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 419947008246 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 419947008247 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 419947008248 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 419947008249 acyltransferase PapA5; Provisional; Region: PRK09294 419947008250 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 419947008251 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 419947008252 active site 419947008253 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 419947008254 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 419947008255 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 419947008256 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 419947008257 Enoylreductase; Region: PKS_ER; smart00829 419947008258 NAD(P) binding site [chemical binding]; other site 419947008259 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 419947008260 KR domain; Region: KR; pfam08659 419947008261 putative NADP binding site [chemical binding]; other site 419947008262 active site 419947008263 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 419947008264 acyl-CoA synthetase; Validated; Region: PRK05850 419947008265 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 419947008266 acyl-activating enzyme (AAE) consensus motif; other site 419947008267 active site 419947008268 MMPL family; Region: MMPL; pfam03176 419947008269 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 419947008270 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 419947008271 Integrase core domain; Region: rve; pfam00665 419947008272 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 419947008273 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 419947008274 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 419947008275 ATP binding site [chemical binding]; other site 419947008276 Walker A motif; other site 419947008277 Walker B motif; other site 419947008278 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 419947008279 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 419947008280 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 419947008281 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 419947008282 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 419947008283 Enoylreductase; Region: PKS_ER; smart00829 419947008284 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 419947008285 NAD(P) binding site [chemical binding]; other site 419947008286 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 419947008287 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 419947008288 putative NADP binding site [chemical binding]; other site 419947008289 active site 419947008290 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 419947008291 Erythronolide synthase docking; Region: Docking; pfam08990 419947008292 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 419947008293 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 419947008294 active site 419947008295 acyl-CoA synthetase; Validated; Region: PRK06060 419947008296 Benzoate CoA ligase (BCL) and similar adenylate forming enzymes; Region: BCL_like; cd05919 419947008297 dimer interface [polypeptide binding]; other site 419947008298 acyl-activating enzyme (AAE) consensus motif; other site 419947008299 putative active site [active] 419947008300 putative AMP binding site [chemical binding]; other site 419947008301 putative CoA binding site [chemical binding]; other site 419947008302 chemical substrate binding site [chemical binding]; other site 419947008303 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 419947008304 4-hydroxybenzoate synthetase (chorismate lyase) [Coenzyme metabolism]; Region: UbiC; COG3161 419947008305 acyl-CoA synthetase; Validated; Region: PRK05850 419947008306 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 419947008307 acyl-activating enzyme (AAE) consensus motif; other site 419947008308 active site 419947008309 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 419947008310 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 419947008311 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 419947008312 S-adenosylmethionine binding site [chemical binding]; other site 419947008313 Uncharacterized conserved protein [Function unknown]; Region: COG3268 419947008314 Methyltransferase domain; Region: Methyltransf_23; pfam13489 419947008315 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 419947008316 S-adenosylmethionine binding site [chemical binding]; other site 419947008317 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 419947008318 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 419947008319 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 419947008320 metal-binding site 419947008321 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 419947008322 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 419947008323 active site 419947008324 TDP-binding site; other site 419947008325 acceptor substrate-binding pocket; other site 419947008326 Cephalosporin hydroxylase [Defense mechanisms]; Region: CmcI; COG3510 419947008327 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 419947008328 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 419947008329 active site 419947008330 TDP-binding site; other site 419947008331 acceptor substrate-binding pocket; other site 419947008332 Predicted permease; Region: DUF318; pfam03773 419947008333 formyltetrahydrofolate deformylase; Region: PurU; TIGR00655 419947008334 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 419947008335 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 419947008336 putative active site [active] 419947008337 putative substrate binding site [chemical binding]; other site 419947008338 putative cosubstrate binding site; other site 419947008339 catalytic site [active] 419947008340 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 419947008341 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 419947008342 active site 419947008343 (T/H)XGH motif; other site 419947008344 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 419947008345 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 419947008346 S-adenosylmethionine binding site [chemical binding]; other site 419947008347 pyruvate carboxylase; Reviewed; Region: PRK12999 419947008348 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 419947008349 ATP-grasp domain; Region: ATP-grasp_4; cl17255 419947008350 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 419947008351 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 419947008352 active site 419947008353 catalytic residues [active] 419947008354 metal binding site [ion binding]; metal-binding site 419947008355 homodimer binding site [polypeptide binding]; other site 419947008356 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 419947008357 carboxyltransferase (CT) interaction site; other site 419947008358 biotinylation site [posttranslational modification]; other site 419947008359 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 419947008360 putative active site [active] 419947008361 redox center [active] 419947008362 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 419947008363 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 419947008364 catalytic residues [active] 419947008365 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 419947008366 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 419947008367 substrate binding pocket [chemical binding]; other site 419947008368 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 419947008369 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 419947008370 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 419947008371 active site 419947008372 catalytic tetrad [active] 419947008373 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 419947008374 RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200 419947008375 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 419947008376 generic binding surface II; other site 419947008377 ssDNA binding site; other site 419947008378 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 419947008379 ATP binding site [chemical binding]; other site 419947008380 putative Mg++ binding site [ion binding]; other site 419947008381 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 419947008382 nucleotide binding region [chemical binding]; other site 419947008383 ATP-binding site [chemical binding]; other site 419947008384 DAK2 domain; Region: Dak2; cl03685 419947008385 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 419947008386 DAK2 domain; Region: Dak2; cl03685 419947008387 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 419947008388 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 419947008389 ligand binding site [chemical binding]; other site 419947008390 active site 419947008391 UGI interface [polypeptide binding]; other site 419947008392 catalytic site [active] 419947008393 thiamine monophosphate kinase; Provisional; Region: PRK05731 419947008394 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 419947008395 ATP binding site [chemical binding]; other site 419947008396 dimerization interface [polypeptide binding]; other site 419947008397 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 419947008398 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 419947008399 Probable transposase; Region: OrfB_IS605; pfam01385 419947008400 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 419947008401 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 419947008402 catalytic residues [active] 419947008403 catalytic nucleophile [active] 419947008404 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 419947008405 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 419947008406 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 419947008407 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 419947008408 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 419947008409 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 419947008410 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 419947008411 Predicted nucleotidyltransferase, CobY/MobA/RfbA family [General function prediction only]; Region: COG1920 419947008412 polyphosphate kinase; Provisional; Region: PRK05443 419947008413 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 419947008414 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 419947008415 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 419947008416 putative domain interface [polypeptide binding]; other site 419947008417 putative active site [active] 419947008418 catalytic site [active] 419947008419 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 419947008420 putative domain interface [polypeptide binding]; other site 419947008421 putative active site [active] 419947008422 catalytic site [active] 419947008423 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 419947008424 active site 419947008425 Ap6A binding site [chemical binding]; other site 419947008426 nudix motif; other site 419947008427 metal binding site [ion binding]; metal-binding site 419947008428 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 419947008429 catalytic core [active] 419947008430 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 419947008431 IHF - DNA interface [nucleotide binding]; other site 419947008432 IHF dimer interface [polypeptide binding]; other site 419947008433 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 419947008434 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 419947008435 substrate binding site [chemical binding]; other site 419947008436 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 419947008437 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 419947008438 substrate binding site [chemical binding]; other site 419947008439 ligand binding site [chemical binding]; other site 419947008440 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 419947008441 Transcriptional regulator [Transcription]; Region: IclR; COG1414 419947008442 Bacterial transcriptional regulator; Region: IclR; pfam01614 419947008443 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 419947008444 S-adenosylmethionine binding site [chemical binding]; other site 419947008445 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 419947008446 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 419947008447 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 419947008448 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 419947008449 active site 419947008450 HIGH motif; other site 419947008451 nucleotide binding site [chemical binding]; other site 419947008452 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 419947008453 active site 419947008454 KMSKS motif; other site 419947008455 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 419947008456 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 419947008457 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 419947008458 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 419947008459 Major Facilitator Superfamily; Region: MFS_1; pfam07690 419947008460 putative substrate translocation pore; other site 419947008461 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 419947008462 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 419947008463 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 419947008464 ligand binding site [chemical binding]; other site 419947008465 NAD binding site [chemical binding]; other site 419947008466 dimerization interface [polypeptide binding]; other site 419947008467 catalytic site [active] 419947008468 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 419947008469 putative L-serine binding site [chemical binding]; other site 419947008470 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 419947008471 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 419947008472 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 419947008473 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 419947008474 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 419947008475 ketol-acid reductoisomerase; Provisional; Region: PRK05479 419947008476 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 419947008477 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 419947008478 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 419947008479 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 419947008480 putative valine binding site [chemical binding]; other site 419947008481 dimer interface [polypeptide binding]; other site 419947008482 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 419947008483 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 419947008484 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 419947008485 PYR/PP interface [polypeptide binding]; other site 419947008486 dimer interface [polypeptide binding]; other site 419947008487 TPP binding site [chemical binding]; other site 419947008488 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 419947008489 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 419947008490 TPP-binding site [chemical binding]; other site 419947008491 dimer interface [polypeptide binding]; other site 419947008492 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 419947008493 Predicted membrane protein [Function unknown]; Region: COG2259 419947008494 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 419947008495 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 419947008496 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 419947008497 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 419947008498 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 419947008499 GatB domain; Region: GatB_Yqey; smart00845 419947008500 6-phosphofructokinase; Provisional; Region: PRK03202 419947008501 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 419947008502 active site 419947008503 ADP/pyrophosphate binding site [chemical binding]; other site 419947008504 dimerization interface [polypeptide binding]; other site 419947008505 allosteric effector site; other site 419947008506 fructose-1,6-bisphosphate binding site; other site 419947008507 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 419947008508 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 419947008509 aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, C subunit; Region: gatC; TIGR00135 419947008510 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 419947008511 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 419947008512 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 419947008513 nucleotide binding pocket [chemical binding]; other site 419947008514 K-X-D-G motif; other site 419947008515 catalytic site [active] 419947008516 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 419947008517 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 419947008518 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 419947008519 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 419947008520 Dimer interface [polypeptide binding]; other site 419947008521 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 419947008522 PknH-like extracellular domain; Region: PknH_C; pfam14032 419947008523 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 419947008524 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947008525 PPE family; Region: PPE; pfam00823 419947008526 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 419947008527 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947008528 PPE family; Region: PPE; pfam00823 419947008529 Transposase, Mutator family; Region: Transposase_mut; pfam00872 419947008530 MULE transposase domain; Region: MULE; pfam10551 419947008531 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 419947008532 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 419947008533 Ligand Binding Site [chemical binding]; other site 419947008534 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 419947008535 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 419947008536 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 419947008537 catalytic residue [active] 419947008538 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 419947008539 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 419947008540 putative acyl-acceptor binding pocket; other site 419947008541 Putative hemolysin [General function prediction only]; Region: COG3176 419947008542 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 419947008543 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 419947008544 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 419947008545 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 419947008546 Ligand binding site [chemical binding]; other site 419947008547 Electron transfer flavoprotein domain; Region: ETF; pfam01012 419947008548 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 419947008549 S-adenosylmethionine binding site [chemical binding]; other site 419947008550 Uncharacterized conserved protein [Function unknown]; Region: COG1543 419947008551 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 419947008552 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 419947008553 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 419947008554 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 419947008555 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 419947008556 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 419947008557 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 419947008558 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 419947008559 trimer interface [polypeptide binding]; other site 419947008560 active site 419947008561 substrate binding site [chemical binding]; other site 419947008562 CoA binding site [chemical binding]; other site 419947008563 FOG: WD40-like repeat [Function unknown]; Region: COG1520 419947008564 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 419947008565 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 419947008566 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 419947008567 S-adenosylmethionine binding site [chemical binding]; other site 419947008568 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 419947008569 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 419947008570 substrate binding site [chemical binding]; other site 419947008571 oxyanion hole (OAH) forming residues; other site 419947008572 trimer interface [polypeptide binding]; other site 419947008573 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 419947008574 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 419947008575 Walker A/P-loop; other site 419947008576 ATP binding site [chemical binding]; other site 419947008577 Q-loop/lid; other site 419947008578 ABC transporter signature motif; other site 419947008579 Walker B; other site 419947008580 D-loop; other site 419947008581 H-loop/switch region; other site 419947008582 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 419947008583 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 419947008584 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 419947008585 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 419947008586 motif II; other site 419947008587 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 419947008588 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 419947008589 D-pathway; other site 419947008590 Putative ubiquinol binding site [chemical binding]; other site 419947008591 Low-spin heme (heme b) binding site [chemical binding]; other site 419947008592 Putative water exit pathway; other site 419947008593 Binuclear center (heme o3/CuB) [ion binding]; other site 419947008594 K-pathway; other site 419947008595 Putative proton exit pathway; other site 419947008596 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 419947008597 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 419947008598 siderophore binding site; other site 419947008599 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 419947008600 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 419947008601 putative NAD(P) binding site [chemical binding]; other site 419947008602 putative substrate binding site [chemical binding]; other site 419947008603 catalytic Zn binding site [ion binding]; other site 419947008604 structural Zn binding site [ion binding]; other site 419947008605 dimer interface [polypeptide binding]; other site 419947008606 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 419947008607 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 419947008608 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 419947008609 dimer interface [polypeptide binding]; other site 419947008610 putative radical transfer pathway; other site 419947008611 diiron center [ion binding]; other site 419947008612 tyrosyl radical; other site 419947008613 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 419947008614 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 419947008615 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 419947008616 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 419947008617 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 419947008618 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 419947008619 Class I ribonucleotide reductase; Region: RNR_I; cd01679 419947008620 active site 419947008621 dimer interface [polypeptide binding]; other site 419947008622 catalytic residues [active] 419947008623 effector binding site; other site 419947008624 R2 peptide binding site; other site 419947008625 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 419947008626 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 419947008627 catalytic residues [active] 419947008628 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 419947008629 Predicted flavoprotein [General function prediction only]; Region: COG0431 419947008630 DNA polymerase IV; Validated; Region: PRK03352 419947008631 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 419947008632 active site 419947008633 DNA binding site [nucleotide binding] 419947008634 short chain dehydrogenase; Provisional; Region: PRK07832 419947008635 classical (c) SDRs; Region: SDR_c; cd05233 419947008636 NAD(P) binding site [chemical binding]; other site 419947008637 active site 419947008638 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 419947008639 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 419947008640 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 419947008641 Cytochrome P450; Region: p450; cl12078 419947008642 Transcriptional regulators [Transcription]; Region: FadR; COG2186 419947008643 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 419947008644 DNA-binding site [nucleotide binding]; DNA binding site 419947008645 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 419947008646 Transcriptional regulators [Transcription]; Region: FadR; COG2186 419947008647 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 419947008648 DNA-binding site [nucleotide binding]; DNA binding site 419947008649 FCD domain; Region: FCD; pfam07729 419947008650 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 419947008651 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 419947008652 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 419947008653 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 419947008654 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 419947008655 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 419947008656 active site 419947008657 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 419947008658 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 419947008659 active site 419947008660 DNA binding site [nucleotide binding] 419947008661 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 419947008662 DNA binding site [nucleotide binding] 419947008663 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 419947008664 Carbon starvation protein CstA; Region: CstA; pfam02554 419947008665 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 419947008666 Predicted membrane protein [Function unknown]; Region: COG2259 419947008667 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 419947008668 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 419947008669 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 419947008670 Protein of unknown function (DUF732); Region: DUF732; pfam05305 419947008671 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 419947008672 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 419947008673 active site 419947008674 substrate binding site [chemical binding]; other site 419947008675 metal binding site [ion binding]; metal-binding site 419947008676 camphor resistance protein CrcB; Provisional; Region: PRK14216 419947008677 camphor resistance protein CrcB; Provisional; Region: PRK14228 419947008678 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 419947008679 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 419947008680 Uncharacterized ACR, COG1993; Region: DUF190; pfam02641 419947008681 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 419947008682 Uncharacterized conserved protein [Function unknown]; Region: COG3189 419947008683 Domain of unknown function (DUF222); Region: DUF222; pfam02720 419947008684 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 419947008685 active site 419947008686 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 419947008687 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 419947008688 putative hydrophobic ligand binding site [chemical binding]; other site 419947008689 protein interface [polypeptide binding]; other site 419947008690 gate; other site 419947008691 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 419947008692 Sulfatase; Region: Sulfatase; pfam00884 419947008693 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 419947008694 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 419947008695 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 419947008696 Catalytic domain of Protein Kinases; Region: PKc; cd00180 419947008697 active site 419947008698 ATP binding site [chemical binding]; other site 419947008699 substrate binding site [chemical binding]; other site 419947008700 activation loop (A-loop); other site 419947008701 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 419947008702 AAA ATPase domain; Region: AAA_16; pfam13191 419947008703 Nucleotidyl transferase of unknown function (DUF2204); Region: DUF2204; pfam09970 419947008704 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 419947008705 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 419947008706 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 419947008707 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 419947008708 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 419947008709 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 419947008710 short chain dehydrogenase; Provisional; Region: PRK07832 419947008711 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 419947008712 NAD(P) binding site [chemical binding]; other site 419947008713 active site 419947008714 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 419947008715 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 419947008716 NAD binding site [chemical binding]; other site 419947008717 catalytic Zn binding site [ion binding]; other site 419947008718 substrate binding site [chemical binding]; other site 419947008719 structural Zn binding site [ion binding]; other site 419947008720 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 419947008721 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 419947008722 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 419947008723 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 419947008724 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 419947008725 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 419947008726 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 419947008727 acyl-activating enzyme (AAE) consensus motif; other site 419947008728 AMP binding site [chemical binding]; other site 419947008729 active site 419947008730 CoA binding site [chemical binding]; other site 419947008731 SPFH domain / Band 7 family; Region: Band_7; pfam01145 419947008732 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 419947008733 Patatin-like phospholipase; Region: Patatin; pfam01734 419947008734 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 419947008735 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 419947008736 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 419947008737 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 419947008738 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 419947008739 active site 419947008740 Predicted transcriptional regulators [Transcription]; Region: COG1733 419947008741 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 419947008742 dimerization interface [polypeptide binding]; other site 419947008743 putative DNA binding site [nucleotide binding]; other site 419947008744 putative Zn2+ binding site [ion binding]; other site 419947008745 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 419947008746 PE family; Region: PE; pfam00934 419947008747 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 419947008748 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 419947008749 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 419947008750 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 419947008751 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 419947008752 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 419947008753 SmpB-tmRNA interface; other site 419947008754 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 419947008755 FtsX-like permease family; Region: FtsX; pfam02687 419947008756 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 419947008757 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 419947008758 Walker A/P-loop; other site 419947008759 ATP binding site [chemical binding]; other site 419947008760 Q-loop/lid; other site 419947008761 ABC transporter signature motif; other site 419947008762 Walker B; other site 419947008763 D-loop; other site 419947008764 H-loop/switch region; other site 419947008765 Mechanosensitive ion channel; Region: MS_channel; pfam00924 419947008766 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 419947008767 peptide chain release factor 2; Validated; Region: prfB; PRK00578 419947008768 This domain is found in peptide chain release factors; Region: PCRF; smart00937 419947008769 RF-1 domain; Region: RF-1; pfam00472 419947008770 ferredoxin-NADP+ reductase; Region: PLN02852 419947008771 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 419947008772 FAD binding domain; Region: FAD_binding_4; pfam01565 419947008773 Molybdenum cofactor biosynthesis enzyme [Coenzyme metabolism]; Region: MoaA; COG2896 419947008774 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 419947008775 FeS/SAM binding site; other site 419947008776 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 419947008777 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 419947008778 aromatic arch; other site 419947008779 DCoH dimer interaction site [polypeptide binding]; other site 419947008780 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 419947008781 DCoH tetramer interaction site [polypeptide binding]; other site 419947008782 substrate binding site [chemical binding]; other site 419947008783 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 419947008784 trimer interface [polypeptide binding]; other site 419947008785 dimer interface [polypeptide binding]; other site 419947008786 putative active site [active] 419947008787 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 419947008788 MoaE interaction surface [polypeptide binding]; other site 419947008789 MoeB interaction surface [polypeptide binding]; other site 419947008790 thiocarboxylated glycine; other site 419947008791 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 419947008792 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 419947008793 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 419947008794 nucleoside/Zn binding site; other site 419947008795 dimer interface [polypeptide binding]; other site 419947008796 catalytic motif [active] 419947008797 Transposase, Mutator family; Region: Transposase_mut; pfam00872 419947008798 MULE transposase domain; Region: MULE; pfam10551 419947008799 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 419947008800 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 419947008801 ATP binding site [chemical binding]; other site 419947008802 substrate interface [chemical binding]; other site 419947008803 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 419947008804 active site residue [active] 419947008805 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 419947008806 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 419947008807 active site residue [active] 419947008808 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 419947008809 active site residue [active] 419947008810 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 419947008811 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 419947008812 MoaE homodimer interface [polypeptide binding]; other site 419947008813 MoaD interaction [polypeptide binding]; other site 419947008814 active site residues [active] 419947008815 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 419947008816 S-adenosylmethionine binding site [chemical binding]; other site 419947008817 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 419947008818 Cytochrome P450; Region: p450; cl12078 419947008819 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 419947008820 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 419947008821 DNA binding site [nucleotide binding] 419947008822 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947008823 PPE family; Region: PPE; pfam00823 419947008824 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 419947008825 Integrase core domain; Region: rve; cl01316 419947008826 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 419947008827 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 419947008828 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 419947008829 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 419947008830 dimer interface [polypeptide binding]; other site 419947008831 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 419947008832 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 419947008833 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 419947008834 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 419947008835 Histidine kinase; Region: HisKA_3; pfam07730 419947008836 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 419947008837 ATP binding site [chemical binding]; other site 419947008838 Mg2+ binding site [ion binding]; other site 419947008839 G-X-G motif; other site 419947008840 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 419947008841 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 419947008842 active site 419947008843 phosphorylation site [posttranslational modification] 419947008844 intermolecular recognition site; other site 419947008845 dimerization interface [polypeptide binding]; other site 419947008846 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 419947008847 DNA binding residues [nucleotide binding] 419947008848 dimerization interface [polypeptide binding]; other site 419947008849 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 419947008850 Ligand Binding Site [chemical binding]; other site 419947008851 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947008852 PPE family; Region: PPE; pfam00823 419947008853 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947008854 PPE family; Region: PPE; pfam00823 419947008855 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 419947008856 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 419947008857 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 419947008858 active site 419947008859 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 419947008860 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 419947008861 FeS/SAM binding site; other site 419947008862 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 419947008863 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 419947008864 active site 419947008865 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 419947008866 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 419947008867 active site 419947008868 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 419947008869 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 419947008870 NAD(P) binding site [chemical binding]; other site 419947008871 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 419947008872 active site 419947008873 phosphorylation site [posttranslational modification] 419947008874 intermolecular recognition site; other site 419947008875 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947008876 PPE family; Region: PPE; pfam00823 419947008877 NADH dehydrogenase subunit A; Validated; Region: PRK07928 419947008878 NADH dehydrogenase subunit B; Validated; Region: PRK06411 419947008879 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 419947008880 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 419947008881 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 419947008882 NADH dehydrogenase subunit D; Validated; Region: PRK06075 419947008883 NADH dehydrogenase subunit E; Validated; Region: PRK07539 419947008884 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 419947008885 putative dimer interface [polypeptide binding]; other site 419947008886 [2Fe-2S] cluster binding site [ion binding]; other site 419947008887 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 419947008888 SLBB domain; Region: SLBB; pfam10531 419947008889 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 419947008890 NADH dehydrogenase subunit G; Validated; Region: PRK07860 419947008891 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 419947008892 catalytic loop [active] 419947008893 iron binding site [ion binding]; other site 419947008894 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 419947008895 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 419947008896 [4Fe-4S] binding site [ion binding]; other site 419947008897 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 419947008898 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 419947008899 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 419947008900 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 419947008901 4Fe-4S binding domain; Region: Fer4; pfam00037 419947008902 4Fe-4S binding domain; Region: Fer4; pfam00037 419947008903 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 419947008904 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 419947008905 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 419947008906 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 419947008907 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 419947008908 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 419947008909 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 419947008910 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 419947008911 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 419947008912 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947008913 PPE family; Region: PPE; pfam00823 419947008914 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 419947008915 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 419947008916 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 419947008917 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 419947008918 [2Fe-2S] cluster binding site [ion binding]; other site 419947008919 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_1; cd08885 419947008920 putative alpha subunit interface [polypeptide binding]; other site 419947008921 putative active site [active] 419947008922 putative substrate binding site [chemical binding]; other site 419947008923 Fe binding site [ion binding]; other site 419947008924 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 419947008925 Protein of unknown function DUF58; Region: DUF58; pfam01882 419947008926 MoxR-like ATPases [General function prediction only]; Region: COG0714 419947008927 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 419947008928 Walker A motif; other site 419947008929 ATP binding site [chemical binding]; other site 419947008930 Walker B motif; other site 419947008931 arginine finger; other site 419947008932 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 419947008933 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 419947008934 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 419947008935 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 419947008936 putative active site [active] 419947008937 putative substrate binding site [chemical binding]; other site 419947008938 ATP binding site [chemical binding]; other site 419947008939 Phosphotransferase enzyme family; Region: APH; pfam01636 419947008940 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 419947008941 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 419947008942 hydroxyglutarate oxidase; Provisional; Region: PRK11728 419947008943 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 419947008944 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 419947008945 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 419947008946 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 419947008947 short chain dehydrogenase; Validated; Region: PRK08264 419947008948 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 419947008949 NAD(P) binding site [chemical binding]; other site 419947008950 active site 419947008951 amidase; Provisional; Region: PRK06170 419947008952 Amidase; Region: Amidase; pfam01425 419947008953 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 419947008954 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 419947008955 TAP-like protein; Region: Abhydrolase_4; pfam08386 419947008956 Domain of unknown function (DUF385); Region: DUF385; pfam04075 419947008957 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 419947008958 AAA domain; Region: AAA_14; pfam13173 419947008959 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 419947008960 putative active site [active] 419947008961 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 419947008962 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4683 419947008963 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 419947008964 non-specific DNA binding site [nucleotide binding]; other site 419947008965 salt bridge; other site 419947008966 sequence-specific DNA binding site [nucleotide binding]; other site 419947008967 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 419947008968 Transposase; Region: HTH_Tnp_1; cl17663 419947008969 putative transposase OrfB; Reviewed; Region: PHA02517 419947008970 HTH-like domain; Region: HTH_21; pfam13276 419947008971 Integrase core domain; Region: rve; pfam00665 419947008972 Integrase core domain; Region: rve_3; pfam13683 419947008973 RES domain; Region: RES; pfam08808 419947008974 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 419947008975 Helix-turn-helix domain; Region: HTH_38; pfam13936 419947008976 Integrase core domain; Region: rve; pfam00665 419947008977 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 419947008978 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 419947008979 hypothetical protein; Validated; Region: PRK00068 419947008980 Uncharacterized conserved protein [Function unknown]; Region: COG1615 419947008981 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 419947008982 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 419947008983 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 419947008984 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 419947008985 Uncharacterized conserved protein [Function unknown]; Region: COG5282 419947008986 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 419947008987 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 419947008988 ABC1 family; Region: ABC1; pfam03109 419947008989 Phosphotransferase enzyme family; Region: APH; pfam01636 419947008990 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 419947008991 active site 419947008992 ATP binding site [chemical binding]; other site 419947008993 Transcription factor WhiB; Region: Whib; pfam02467 419947008994 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 419947008995 Part of AAA domain; Region: AAA_19; pfam13245 419947008996 Family description; Region: UvrD_C_2; pfam13538 419947008997 HRDC domain; Region: HRDC; pfam00570 419947008998 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 419947008999 catalytic residues [active] 419947009000 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 419947009001 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 419947009002 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 419947009003 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 419947009004 putative NADH binding site [chemical binding]; other site 419947009005 putative active site [active] 419947009006 nudix motif; other site 419947009007 putative metal binding site [ion binding]; other site 419947009008 Ion channel; Region: Ion_trans_2; pfam07885 419947009009 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 419947009010 TrkA-N domain; Region: TrkA_N; pfam02254 419947009011 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 419947009012 Part of AAA domain; Region: AAA_19; pfam13245 419947009013 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 419947009014 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 419947009015 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 419947009016 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 419947009017 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 419947009018 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 419947009019 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 419947009020 active site 419947009021 DNA binding site [nucleotide binding] 419947009022 TIGR02569 family protein; Region: TIGR02569_actnb 419947009023 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 419947009024 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 419947009025 ATP binding site [chemical binding]; other site 419947009026 substrate interface [chemical binding]; other site 419947009027 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 419947009028 active site residue [active] 419947009029 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 419947009030 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 419947009031 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 419947009032 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 419947009033 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like; Region: MiaE_2; pfam13794 419947009034 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 419947009035 DEAD-like helicases superfamily; Region: DEXDc; smart00487 419947009036 ATP binding site [chemical binding]; other site 419947009037 Mg++ binding site [ion binding]; other site 419947009038 motif III; other site 419947009039 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 419947009040 nucleotide binding region [chemical binding]; other site 419947009041 ATP-binding site [chemical binding]; other site 419947009042 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 419947009043 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 419947009044 P-loop; other site 419947009045 Magnesium ion binding site [ion binding]; other site 419947009046 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 419947009047 Magnesium ion binding site [ion binding]; other site 419947009048 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 419947009049 catalytic core [active] 419947009050 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 419947009051 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 419947009052 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 419947009053 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 419947009054 Transcription factor WhiB; Region: Whib; pfam02467 419947009055 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 419947009056 PAS domain S-box; Region: sensory_box; TIGR00229 419947009057 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 419947009058 Histidine kinase; Region: HisKA_2; pfam07568 419947009059 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 419947009060 ATP binding site [chemical binding]; other site 419947009061 Mg2+ binding site [ion binding]; other site 419947009062 G-X-G motif; other site 419947009063 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 419947009064 carboxyltransferase (CT) interaction site; other site 419947009065 biotinylation site [posttranslational modification]; other site 419947009066 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 419947009067 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 419947009068 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 419947009069 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 419947009070 DNA binding residues [nucleotide binding] 419947009071 short chain dehydrogenase; Provisional; Region: PRK08278 419947009072 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 419947009073 NAD(P) binding site [chemical binding]; other site 419947009074 homodimer interface [polypeptide binding]; other site 419947009075 active site 419947009076 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 419947009077 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 419947009078 Coenzyme A binding pocket [chemical binding]; other site 419947009079 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 419947009080 Phosphotransferase enzyme family; Region: APH; pfam01636 419947009081 putative active site [active] 419947009082 putative substrate binding site [chemical binding]; other site 419947009083 ATP binding site [chemical binding]; other site 419947009084 Uncharacterized conserved protein [Function unknown]; Region: COG2135 419947009085 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 419947009086 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 419947009087 hinge; other site 419947009088 active site 419947009089 Predicted GTPases [General function prediction only]; Region: COG1162 419947009090 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 419947009091 GTPase/Zn-binding domain interface [polypeptide binding]; other site 419947009092 GTP/Mg2+ binding site [chemical binding]; other site 419947009093 G4 box; other site 419947009094 G5 box; other site 419947009095 G1 box; other site 419947009096 Switch I region; other site 419947009097 G2 box; other site 419947009098 G3 box; other site 419947009099 Switch II region; other site 419947009100 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 419947009101 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 419947009102 putative di-iron ligands [ion binding]; other site 419947009103 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 419947009104 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 419947009105 FAD binding pocket [chemical binding]; other site 419947009106 FAD binding motif [chemical binding]; other site 419947009107 phosphate binding motif [ion binding]; other site 419947009108 beta-alpha-beta structure motif; other site 419947009109 NAD binding pocket [chemical binding]; other site 419947009110 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 419947009111 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 419947009112 catalytic loop [active] 419947009113 iron binding site [ion binding]; other site 419947009114 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 419947009115 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 419947009116 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 419947009117 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 419947009118 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 419947009119 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 419947009120 TrkA-C domain; Region: TrkA_C; pfam02080 419947009121 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 419947009122 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 419947009123 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 419947009124 putative substrate translocation pore; other site 419947009125 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 419947009126 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 419947009127 ligand binding site [chemical binding]; other site 419947009128 flexible hinge region; other site 419947009129 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 419947009130 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 419947009131 nucleophile elbow; other site 419947009132 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 419947009133 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 419947009134 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 419947009135 30S subunit binding site; other site 419947009136 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 419947009137 active site 419947009138 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 419947009139 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 419947009140 lipoprotein LpqB; Provisional; Region: PRK13616 419947009141 Sporulation and spore germination; Region: Germane; pfam10646 419947009142 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 419947009143 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 419947009144 dimerization interface [polypeptide binding]; other site 419947009145 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 419947009146 dimer interface [polypeptide binding]; other site 419947009147 phosphorylation site [posttranslational modification] 419947009148 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 419947009149 ATP binding site [chemical binding]; other site 419947009150 Mg2+ binding site [ion binding]; other site 419947009151 G-X-G motif; other site 419947009152 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 419947009153 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 419947009154 active site 419947009155 phosphorylation site [posttranslational modification] 419947009156 intermolecular recognition site; other site 419947009157 dimerization interface [polypeptide binding]; other site 419947009158 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 419947009159 DNA binding site [nucleotide binding] 419947009160 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 419947009161 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 419947009162 TMP-binding site; other site 419947009163 ATP-binding site [chemical binding]; other site 419947009164 Adenosylhomocysteinase; Provisional; Region: PTZ00075 419947009165 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 419947009166 homotetramer interface [polypeptide binding]; other site 419947009167 ligand binding site [chemical binding]; other site 419947009168 catalytic site [active] 419947009169 NAD binding site [chemical binding]; other site 419947009170 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 419947009171 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 419947009172 Rubredoxin [Energy production and conversion]; Region: COG1773 419947009173 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 419947009174 iron binding site [ion binding]; other site 419947009175 Rubredoxin [Energy production and conversion]; Region: COG1773 419947009176 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 419947009177 iron binding site [ion binding]; other site 419947009178 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 419947009179 Fatty acid desaturase; Region: FA_desaturase; pfam00487 419947009180 Di-iron ligands [ion binding]; other site 419947009181 amino acid transporter; Region: 2A0306; TIGR00909 419947009182 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 419947009183 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 419947009184 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 419947009185 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 419947009186 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 419947009187 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 419947009188 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 419947009189 active site 419947009190 substrate binding site [chemical binding]; other site 419947009191 metal binding site [ion binding]; metal-binding site 419947009192 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 419947009193 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 419947009194 Transcription factor WhiB; Region: Whib; pfam02467 419947009195 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 419947009196 LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186 419947009197 phosphate binding site [ion binding]; other site 419947009198 dimer interface [polypeptide binding]; other site 419947009199 substrate binding site [chemical binding]; other site 419947009200 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 419947009201 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 419947009202 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 419947009203 putative FMN binding site [chemical binding]; other site 419947009204 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 419947009205 Methyltransferase domain; Region: Methyltransf_26; pfam13659 419947009206 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 419947009207 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 419947009208 active site 419947009209 Substrate binding site; other site 419947009210 Mg++ binding site; other site 419947009211 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 419947009212 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 419947009213 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 419947009214 Probable Catalytic site; other site 419947009215 metal-binding site 419947009216 dTDP-4-dehydrorhamnose reductase; Region: rmlD; TIGR01214 419947009217 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 419947009218 NADP binding site [chemical binding]; other site 419947009219 active site 419947009220 putative substrate binding site [chemical binding]; other site 419947009221 Transcriptional regulator [Transcription]; Region: LytR; COG1316 419947009222 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 419947009223 TIGR03089 family protein; Region: TIGR03089 419947009224 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 419947009225 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 419947009226 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 419947009227 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 419947009228 active site 419947009229 motif I; other site 419947009230 motif II; other site 419947009231 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 419947009232 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 419947009233 CoA-transferase family III; Region: CoA_transf_3; pfam02515 419947009234 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 419947009235 Sulfate transporter family; Region: Sulfate_transp; pfam00916 419947009236 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: CynT; COG0288 419947009237 active site clefts [active] 419947009238 zinc binding site [ion binding]; other site 419947009239 dimer interface [polypeptide binding]; other site 419947009240 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 419947009241 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 419947009242 FAD binding site [chemical binding]; other site 419947009243 homotetramer interface [polypeptide binding]; other site 419947009244 substrate binding pocket [chemical binding]; other site 419947009245 catalytic base [active] 419947009246 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 419947009247 Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) [Nucleotide transport and metabolism]; Region: PurK; COG0026 419947009248 ATP-grasp domain; Region: ATP-grasp; pfam02222 419947009249 Predicted membrane protein [Function unknown]; Region: COG2246 419947009250 GtrA-like protein; Region: GtrA; pfam04138 419947009251 Bacterial PH domain; Region: DUF304; pfam03703 419947009252 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 419947009253 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 419947009254 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 419947009255 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 419947009256 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 419947009257 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 419947009258 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 419947009259 Maf-like protein; Region: Maf; pfam02545 419947009260 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 419947009261 active site 419947009262 dimer interface [polypeptide binding]; other site 419947009263 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 419947009264 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 419947009265 active site residue [active] 419947009266 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 419947009267 active site residue [active] 419947009268 Fe-S metabolism associated domain; Region: SufE; pfam02657 419947009269 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 419947009270 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 419947009271 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 419947009272 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 419947009273 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 419947009274 carboxyltransferase (CT) interaction site; other site 419947009275 biotinylation site [posttranslational modification]; other site 419947009276 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 419947009277 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 419947009278 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 419947009279 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 419947009280 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 419947009281 L-lysine aminotransferase; Provisional; Region: PRK08297 419947009282 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 419947009283 inhibitor-cofactor binding pocket; inhibition site 419947009284 pyridoxal 5'-phosphate binding site [chemical binding]; other site 419947009285 catalytic residue [active] 419947009286 putative DNA binding site [nucleotide binding]; other site 419947009287 dimerization interface [polypeptide binding]; other site 419947009288 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 419947009289 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 419947009290 putative Zn2+ binding site [ion binding]; other site 419947009291 AsnC family; Region: AsnC_trans_reg; pfam01037 419947009292 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 419947009293 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 419947009294 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 419947009295 tetrameric interface [polypeptide binding]; other site 419947009296 NAD binding site [chemical binding]; other site 419947009297 catalytic residues [active] 419947009298 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 419947009299 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 419947009300 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 419947009301 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 419947009302 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 419947009303 ATP binding site [chemical binding]; other site 419947009304 putative Mg++ binding site [ion binding]; other site 419947009305 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 419947009306 nucleotide binding region [chemical binding]; other site 419947009307 ATP-binding site [chemical binding]; other site 419947009308 DEAD/H associated; Region: DEAD_assoc; pfam08494 419947009309 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 419947009310 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 419947009311 putative DNA binding site [nucleotide binding]; other site 419947009312 catalytic residue [active] 419947009313 putative H2TH interface [polypeptide binding]; other site 419947009314 putative catalytic residues [active] 419947009315 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 419947009316 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 419947009317 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 419947009318 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 419947009319 Sulfatase; Region: Sulfatase; pfam00884 419947009320 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 419947009321 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 419947009322 probable active site [active] 419947009323 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 419947009324 PhoU domain; Region: PhoU; pfam01895 419947009325 PhoU domain; Region: PhoU; pfam01895 419947009326 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 419947009327 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 419947009328 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 419947009329 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 419947009330 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 419947009331 putative active site pocket [active] 419947009332 dimerization interface [polypeptide binding]; other site 419947009333 putative catalytic residue [active] 419947009334 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 419947009335 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 419947009336 metal binding site [ion binding]; metal-binding site 419947009337 putative dimer interface [polypeptide binding]; other site 419947009338 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 419947009339 amidohydrolase; Region: amidohydrolases; TIGR01891 419947009340 metal binding site [ion binding]; metal-binding site 419947009341 purine nucleoside phosphorylase; Provisional; Region: PRK08202 419947009342 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 419947009343 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 419947009344 active site 419947009345 substrate binding site [chemical binding]; other site 419947009346 metal binding site [ion binding]; metal-binding site 419947009347 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 419947009348 active site 419947009349 Phosphoesterase family; Region: Phosphoesterase; pfam04185 419947009350 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 419947009351 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 419947009352 adenosine deaminase; Provisional; Region: PRK09358 419947009353 active site 419947009354 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 419947009355 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 419947009356 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 419947009357 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 419947009358 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 419947009359 active site 419947009360 catalytic motif [active] 419947009361 Zn binding site [ion binding]; other site 419947009362 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 419947009363 putative Iron-sulfur protein interface [polypeptide binding]; other site 419947009364 putative proximal heme binding site [chemical binding]; other site 419947009365 putative SdhD-like interface [polypeptide binding]; other site 419947009366 putative distal heme binding site [chemical binding]; other site 419947009367 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 419947009368 putative Iron-sulfur protein interface [polypeptide binding]; other site 419947009369 putative proximal heme binding site [chemical binding]; other site 419947009370 putative SdhC-like subunit interface [polypeptide binding]; other site 419947009371 putative distal heme binding site [chemical binding]; other site 419947009372 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 419947009373 L-aspartate oxidase; Provisional; Region: PRK06175 419947009374 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 419947009375 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 419947009376 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 419947009377 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 419947009378 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 419947009379 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 419947009380 S-adenosylmethionine binding site [chemical binding]; other site 419947009381 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 419947009382 MoaE interaction surface [polypeptide binding]; other site 419947009383 MoeB interaction surface [polypeptide binding]; other site 419947009384 thiocarboxylated glycine; other site 419947009385 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 419947009386 MoaE homodimer interface [polypeptide binding]; other site 419947009387 MoaD interaction [polypeptide binding]; other site 419947009388 active site residues [active] 419947009389 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 419947009390 trimer interface [polypeptide binding]; other site 419947009391 dimer interface [polypeptide binding]; other site 419947009392 putative active site [active] 419947009393 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 419947009394 Transposase; Region: HTH_Tnp_1; cl17663 419947009395 putative transposase OrfB; Reviewed; Region: PHA02517 419947009396 HTH-like domain; Region: HTH_21; pfam13276 419947009397 Integrase core domain; Region: rve; pfam00665 419947009398 Integrase core domain; Region: rve_3; pfam13683 419947009399 Transposase; Region: DEDD_Tnp_IS110; pfam01548 419947009400 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 419947009401 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 419947009402 Uncharacterized conserved protein [Function unknown]; Region: COG2128 419947009403 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 419947009404 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 419947009405 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 419947009406 DNA binding residues [nucleotide binding] 419947009407 SnoaL-like domain; Region: SnoaL_2; pfam12680 419947009408 hypothetical protein; Provisional; Region: PRK06541 419947009409 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 419947009410 inhibitor-cofactor binding pocket; inhibition site 419947009411 pyridoxal 5'-phosphate binding site [chemical binding]; other site 419947009412 catalytic residue [active] 419947009413 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 419947009414 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 419947009415 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 419947009416 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 419947009417 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 419947009418 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 419947009419 active site 419947009420 dimer interface [polypeptide binding]; other site 419947009421 Protein of unknown function (DUF732); Region: DUF732; pfam05305 419947009422 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 419947009423 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 419947009424 DNA binding residues [nucleotide binding] 419947009425 dimer interface [polypeptide binding]; other site 419947009426 metal binding site [ion binding]; metal-binding site 419947009427 inner membrane protein YhjD; Region: TIGR00766 419947009428 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 419947009429 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 419947009430 active site 419947009431 HIGH motif; other site 419947009432 dimer interface [polypeptide binding]; other site 419947009433 KMSKS motif; other site 419947009434 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 419947009435 isocitrate dehydrogenase; Validated; Region: PRK08299 419947009436 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 419947009437 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 419947009438 homodimer interface [polypeptide binding]; other site 419947009439 substrate-cofactor binding pocket; other site 419947009440 pyridoxal 5'-phosphate binding site [chemical binding]; other site 419947009441 catalytic residue [active] 419947009442 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 419947009443 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 419947009444 Methyltransferase domain; Region: Methyltransf_23; pfam13489 419947009445 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 419947009446 S-adenosylmethionine binding site [chemical binding]; other site 419947009447 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947009448 PPE family; Region: PPE; pfam00823 419947009449 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947009450 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 419947009451 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 419947009452 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 419947009453 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947009454 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 419947009455 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 419947009456 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947009457 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 419947009458 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 419947009459 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 419947009460 PE family; Region: PE; pfam00934 419947009461 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 419947009462 PPE family; Region: PPE; pfam00823 419947009463 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 419947009464 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 419947009465 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947009466 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 419947009467 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 419947009468 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947009469 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 419947009470 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 419947009471 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947009472 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 419947009473 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 419947009474 Transposase; Region: DEDD_Tnp_IS110; pfam01548 419947009475 Transposase; Region: DDE_Tnp_ISL3; pfam01610 419947009476 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947009477 PPE family; Region: PPE; pfam00823 419947009478 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947009479 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 419947009480 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 419947009481 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947009482 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 419947009483 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 419947009484 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 419947009485 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 419947009486 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947009487 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 419947009488 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 419947009489 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947009490 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 419947009491 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 419947009492 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 419947009493 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 419947009494 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947009495 PPE family; Region: PPE; pfam00823 419947009496 Berberine and berberine like; Region: BBE; pfam08031 419947009497 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 419947009498 Protein of unknown function (DUF732); Region: DUF732; pfam05305 419947009499 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 419947009500 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 419947009501 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 419947009502 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 419947009503 homodimer interface [polypeptide binding]; other site 419947009504 NADP binding site [chemical binding]; other site 419947009505 substrate binding site [chemical binding]; other site 419947009506 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 419947009507 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 419947009508 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 419947009509 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 419947009510 active site 419947009511 FMN binding site [chemical binding]; other site 419947009512 substrate binding site [chemical binding]; other site 419947009513 putative catalytic residue [active] 419947009514 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 419947009515 phosphate binding site [ion binding]; other site 419947009516 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 419947009517 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 419947009518 phosphopeptide binding site; other site 419947009519 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 419947009520 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 419947009521 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 419947009522 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 419947009523 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 419947009524 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 419947009525 G1 box; other site 419947009526 GTP/Mg2+ binding site [chemical binding]; other site 419947009527 G2 box; other site 419947009528 Switch I region; other site 419947009529 G3 box; other site 419947009530 Switch II region; other site 419947009531 G4 box; other site 419947009532 G5 box; other site 419947009533 Protein of unknown function (DUF742); Region: DUF742; pfam05331 419947009534 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 419947009535 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 419947009536 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 419947009537 ATP binding site [chemical binding]; other site 419947009538 Mg2+ binding site [ion binding]; other site 419947009539 G-X-G motif; other site 419947009540 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 419947009541 PE family; Region: PE; pfam00934 419947009542 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 419947009543 FMN binding site [chemical binding]; other site 419947009544 dimer interface [polypeptide binding]; other site 419947009545 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 419947009546 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 419947009547 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 419947009548 active site 419947009549 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 419947009550 generic binding surface II; other site 419947009551 generic binding surface I; other site 419947009552 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 419947009553 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 419947009554 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 419947009555 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 419947009556 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 419947009557 active site 419947009558 motif I; other site 419947009559 motif II; other site 419947009560 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 419947009561 substrate binding site [chemical binding]; other site 419947009562 oxyanion hole (OAH) forming residues; other site 419947009563 trimer interface [polypeptide binding]; other site 419947009564 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 419947009565 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 419947009566 Amidase; Region: Amidase; pfam01425 419947009567 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 419947009568 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 419947009569 motif II; other site 419947009570 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 419947009571 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 419947009572 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 419947009573 TPP-binding site [chemical binding]; other site 419947009574 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 419947009575 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 419947009576 PYR/PP interface [polypeptide binding]; other site 419947009577 dimer interface [polypeptide binding]; other site 419947009578 TPP binding site [chemical binding]; other site 419947009579 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 419947009580 putative transposase OrfB; Reviewed; Region: PHA02517 419947009581 HTH-like domain; Region: HTH_21; pfam13276 419947009582 Integrase core domain; Region: rve; pfam00665 419947009583 Integrase core domain; Region: rve_3; pfam13683 419947009584 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 419947009585 Transposase; Region: HTH_Tnp_1; cl17663 419947009586 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 419947009587 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 419947009588 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 419947009589 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 419947009590 substrate binding pocket [chemical binding]; other site 419947009591 chain length determination region; other site 419947009592 substrate-Mg2+ binding site; other site 419947009593 catalytic residues [active] 419947009594 aspartate-rich region 1; other site 419947009595 active site lid residues [active] 419947009596 aspartate-rich region 2; other site 419947009597 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 419947009598 putative active site [active] 419947009599 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 419947009600 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 419947009601 Transposase domain (DUF772); Region: DUF772; pfam05598 419947009602 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 419947009603 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 419947009604 enoyl-CoA hydratase; Region: PLN02864 419947009605 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 419947009606 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 419947009607 dimer interaction site [polypeptide binding]; other site 419947009608 substrate-binding tunnel; other site 419947009609 active site 419947009610 catalytic site [active] 419947009611 substrate binding site [chemical binding]; other site 419947009612 PE family; Region: PE; pfam00934 419947009613 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 419947009614 short chain dehydrogenase; Provisional; Region: PRK07201 419947009615 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 419947009616 putative NAD(P) binding site [chemical binding]; other site 419947009617 active site 419947009618 putative substrate binding site [chemical binding]; other site 419947009619 classical (c) SDRs; Region: SDR_c; cd05233 419947009620 NAD(P) binding site [chemical binding]; other site 419947009621 active site 419947009622 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 419947009623 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 419947009624 S-adenosylmethionine binding site [chemical binding]; other site 419947009625 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 419947009626 active site 419947009627 DNA Polymerase Y-family; Region: PolY_like; cd03468 419947009628 DNA binding site [nucleotide binding] 419947009629 GMP synthase; Reviewed; Region: guaA; PRK00074 419947009630 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 419947009631 AMP/PPi binding site [chemical binding]; other site 419947009632 candidate oxyanion hole; other site 419947009633 catalytic triad [active] 419947009634 potential glutamine specificity residues [chemical binding]; other site 419947009635 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 419947009636 ATP Binding subdomain [chemical binding]; other site 419947009637 Ligand Binding sites [chemical binding]; other site 419947009638 Dimerization subdomain; other site 419947009639 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 419947009640 active site lid residues [active] 419947009641 substrate binding pocket [chemical binding]; other site 419947009642 catalytic residues [active] 419947009643 substrate-Mg2+ binding site; other site 419947009644 aspartate-rich region 1; other site 419947009645 aspartate-rich region 2; other site 419947009646 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 419947009647 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 419947009648 substrate binding pocket [chemical binding]; other site 419947009649 chain length determination region; other site 419947009650 substrate-Mg2+ binding site; other site 419947009651 catalytic residues [active] 419947009652 aspartate-rich region 1; other site 419947009653 active site lid residues [active] 419947009654 aspartate-rich region 2; other site 419947009655 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 419947009656 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 419947009657 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 419947009658 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 419947009659 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 419947009660 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 419947009661 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 419947009662 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 419947009663 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 419947009664 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 419947009665 inhibitor-cofactor binding pocket; inhibition site 419947009666 pyridoxal 5'-phosphate binding site [chemical binding]; other site 419947009667 catalytic residue [active] 419947009668 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 419947009669 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 419947009670 hypothetical protein; Provisional; Region: PRK07579 419947009671 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 419947009672 active site 419947009673 cosubstrate binding site; other site 419947009674 substrate binding site [chemical binding]; other site 419947009675 catalytic site [active] 419947009676 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 419947009677 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 419947009678 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 419947009679 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 419947009680 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 419947009681 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 419947009682 putative active site [active] 419947009683 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 419947009684 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 419947009685 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 419947009686 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 419947009687 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 419947009688 phosphate binding site [ion binding]; other site 419947009689 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 419947009690 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 419947009691 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 419947009692 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 419947009693 active site 419947009694 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 419947009695 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 419947009696 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 419947009697 DNA binding residues [nucleotide binding] 419947009698 Transcription factor WhiB; Region: Whib; pfam02467 419947009699 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 419947009700 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 419947009701 ring oligomerisation interface [polypeptide binding]; other site 419947009702 ATP/Mg binding site [chemical binding]; other site 419947009703 stacking interactions; other site 419947009704 hinge regions; other site 419947009705 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 419947009706 oligomerisation interface [polypeptide binding]; other site 419947009707 mobile loop; other site 419947009708 roof hairpin; other site 419947009709 UGMP family protein; Validated; Region: PRK09604 419947009710 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 419947009711 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 419947009712 Coenzyme A binding pocket [chemical binding]; other site 419947009713 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 419947009714 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 419947009715 alanine racemase; Reviewed; Region: alr; PRK00053 419947009716 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 419947009717 active site 419947009718 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 419947009719 dimer interface [polypeptide binding]; other site 419947009720 substrate binding site [chemical binding]; other site 419947009721 catalytic residues [active] 419947009722 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947009723 PPE family; Region: PPE; pfam00823 419947009724 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947009725 PPE family; Region: PPE; pfam00823 419947009726 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 419947009727 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 419947009728 Walker A motif; other site 419947009729 ATP binding site [chemical binding]; other site 419947009730 Walker B motif; other site 419947009731 arginine finger; other site 419947009732 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 419947009733 Integrase core domain; Region: rve; pfam00665 419947009734 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947009735 PPE family; Region: PPE; pfam00823 419947009736 Integrase core domain; Region: rve; pfam00665 419947009737 Integrase core domain; Region: rve_3; pfam13683 419947009738 Transposase, Mutator family; Region: Transposase_mut; pfam00872 419947009739 MULE transposase domain; Region: MULE; pfam10551 419947009740 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 419947009741 pyridoxal 5'-phosphate binding site [chemical binding]; other site 419947009742 catalytic residue [active] 419947009743 Uncharacterized conserved protein [Function unknown]; Region: COG0062 419947009744 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 419947009745 putative substrate binding site [chemical binding]; other site 419947009746 putative ATP binding site [chemical binding]; other site 419947009747 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 419947009748 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 419947009749 glutaminase active site [active] 419947009750 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 419947009751 dimer interface [polypeptide binding]; other site 419947009752 active site 419947009753 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 419947009754 dimer interface [polypeptide binding]; other site 419947009755 active site 419947009756 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 419947009757 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 419947009758 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 419947009759 active site 419947009760 substrate binding site [chemical binding]; other site 419947009761 metal binding site [ion binding]; metal-binding site 419947009762 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 419947009763 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 419947009764 23S rRNA interface [nucleotide binding]; other site 419947009765 L3 interface [polypeptide binding]; other site 419947009766 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 419947009767 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 419947009768 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 419947009769 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 419947009770 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 419947009771 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 419947009772 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 419947009773 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 419947009774 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 419947009775 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 419947009776 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 419947009777 active site 419947009778 catalytic residues [active] 419947009779 Protein of unknown function (DUF690); Region: DUF690; pfam05108 419947009780 Cutinase; Region: Cutinase; pfam01083 419947009781 Cutinase; Region: Cutinase; pfam01083 419947009782 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 419947009783 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 419947009784 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 419947009785 active site 419947009786 dimerization interface 3.5A [polypeptide binding]; other site 419947009787 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 419947009788 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 419947009789 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 419947009790 alphaNTD - beta interaction site [polypeptide binding]; other site 419947009791 alphaNTD homodimer interface [polypeptide binding]; other site 419947009792 alphaNTD - beta' interaction site [polypeptide binding]; other site 419947009793 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 419947009794 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 419947009795 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 419947009796 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 419947009797 RNA binding surface [nucleotide binding]; other site 419947009798 30S ribosomal protein S11; Validated; Region: PRK05309 419947009799 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 419947009800 30S ribosomal protein S13; Region: bact_S13; TIGR03631 419947009801 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 419947009802 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 419947009803 rRNA binding site [nucleotide binding]; other site 419947009804 predicted 30S ribosome binding site; other site 419947009805 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 419947009806 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 419947009807 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 419947009808 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 419947009809 NAD binding site [chemical binding]; other site 419947009810 substrate binding site [chemical binding]; other site 419947009811 homodimer interface [polypeptide binding]; other site 419947009812 active site 419947009813 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 419947009814 Domain of unknown function (DUF222); Region: DUF222; pfam02720 419947009815 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 419947009816 active site 419947009817 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 419947009818 extended (e) SDRs; Region: SDR_e; cd08946 419947009819 NAD(P) binding site [chemical binding]; other site 419947009820 active site 419947009821 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 419947009822 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 419947009823 active site 419947009824 catalytic residues [active] 419947009825 metal binding site [ion binding]; metal-binding site 419947009826 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 419947009827 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 419947009828 PYR/PP interface [polypeptide binding]; other site 419947009829 dimer interface [polypeptide binding]; other site 419947009830 TPP binding site [chemical binding]; other site 419947009831 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 419947009832 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 419947009833 TPP-binding site [chemical binding]; other site 419947009834 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 419947009835 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 419947009836 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 419947009837 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 419947009838 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 419947009839 Transposase; Region: HTH_Tnp_1; cl17663 419947009840 putative transposase OrfB; Reviewed; Region: PHA02517 419947009841 HTH-like domain; Region: HTH_21; pfam13276 419947009842 Integrase core domain; Region: rve; pfam00665 419947009843 Integrase core domain; Region: rve_3; pfam13683 419947009844 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 419947009845 metabolite-proton symporter; Region: 2A0106; TIGR00883 419947009846 putative substrate translocation pore; other site 419947009847 PE family; Region: PE; pfam00934 419947009848 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947009849 PPE family; Region: PPE; pfam00823 419947009850 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 419947009851 patatin-related protein; Region: TIGR03607 419947009852 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 419947009853 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 419947009854 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 419947009855 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 419947009856 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 419947009857 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 419947009858 Transcriptional regulator [Transcription]; Region: LytR; COG1316 419947009859 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 419947009860 short chain dehydrogenase; Provisional; Region: PRK05875 419947009861 classical (c) SDRs; Region: SDR_c; cd05233 419947009862 NAD(P) binding site [chemical binding]; other site 419947009863 active site 419947009864 Predicted membrane protein [Function unknown]; Region: COG2259 419947009865 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 419947009866 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 419947009867 Predicted transcriptional regulators [Transcription]; Region: COG1695 419947009868 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 419947009869 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 419947009870 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 419947009871 active site 419947009872 homotetramer interface [polypeptide binding]; other site 419947009873 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 419947009874 mce related protein; Region: MCE; pfam02470 419947009875 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 419947009876 mce related protein; Region: MCE; pfam02470 419947009877 mce related protein; Region: MCE; pfam02470 419947009878 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 419947009879 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 419947009880 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 419947009881 mce related protein; Region: MCE; pfam02470 419947009882 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 419947009883 mce related protein; Region: MCE; pfam02470 419947009884 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 419947009885 mce related protein; Region: MCE; pfam02470 419947009886 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 419947009887 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 419947009888 Permease; Region: Permease; pfam02405 419947009889 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 419947009890 Permease; Region: Permease; pfam02405 419947009891 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 419947009892 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 419947009893 NAD(P) binding site [chemical binding]; other site 419947009894 active site 419947009895 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 419947009896 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 419947009897 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 419947009898 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 419947009899 FAD binding site [chemical binding]; other site 419947009900 substrate binding site [chemical binding]; other site 419947009901 catalytic base [active] 419947009902 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 419947009903 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 419947009904 active site 419947009905 acyl-CoA synthetase; Validated; Region: PRK07867 419947009906 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 419947009907 acyl-activating enzyme (AAE) consensus motif; other site 419947009908 putative AMP binding site [chemical binding]; other site 419947009909 putative active site [active] 419947009910 putative CoA binding site [chemical binding]; other site 419947009911 PE family; Region: PE; pfam00934 419947009912 PE family; Region: PE; pfam00934 419947009913 hypothetical protein; Validated; Region: PRK07586 419947009914 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 419947009915 PYR/PP interface [polypeptide binding]; other site 419947009916 dimer interface [polypeptide binding]; other site 419947009917 TPP binding site [chemical binding]; other site 419947009918 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 419947009919 TPP-binding site [chemical binding]; other site 419947009920 dimer interface [polypeptide binding]; other site 419947009921 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 419947009922 PE family; Region: PE; pfam00934 419947009923 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 419947009924 CoA binding site [chemical binding]; other site 419947009925 PE family; Region: PE; pfam00934 419947009926 acyl-CoA synthetase; Validated; Region: PRK07798 419947009927 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 419947009928 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 419947009929 acyl-activating enzyme (AAE) consensus motif; other site 419947009930 acyl-activating enzyme (AAE) consensus motif; other site 419947009931 putative AMP binding site [chemical binding]; other site 419947009932 putative active site [active] 419947009933 putative CoA binding site [chemical binding]; other site 419947009934 enoyl-CoA hydratase; Provisional; Region: PRK07799 419947009935 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 419947009936 substrate binding site [chemical binding]; other site 419947009937 oxyanion hole (OAH) forming residues; other site 419947009938 trimer interface [polypeptide binding]; other site 419947009939 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 419947009940 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 419947009941 Cytochrome P450; Region: p450; cl12078 419947009942 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 419947009943 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 419947009944 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 419947009945 DUF35 OB-fold domain; Region: DUF35; pfam01796 419947009946 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 419947009947 DUF35 OB-fold domain; Region: DUF35; pfam01796 419947009948 lipid-transfer protein; Provisional; Region: PRK07937 419947009949 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 419947009950 active site 419947009951 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 419947009952 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 419947009953 active site 419947009954 NHL repeat; Region: NHL; pfam01436 419947009955 Uncharacterized conserved protein [Function unknown]; Region: COG3391 419947009956 NHL repeat; Region: NHL; pfam01436 419947009957 NHL repeat; Region: NHL; pfam01436 419947009958 NHL repeat; Region: NHL; pfam01436 419947009959 NHL repeat; Region: NHL; pfam01436 419947009960 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 419947009961 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 419947009962 trimer interface [polypeptide binding]; other site 419947009963 putative metal binding site [ion binding]; other site 419947009964 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 419947009965 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 419947009966 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 419947009967 short chain dehydrogenase; Provisional; Region: PRK07890 419947009968 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 419947009969 NAD(P) binding site [chemical binding]; other site 419947009970 active site 419947009971 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947009972 PPE family; Region: PPE; pfam00823 419947009973 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 419947009974 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947009975 PPE family; Region: PPE; pfam00823 419947009976 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 419947009977 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 419947009978 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 419947009979 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 419947009980 active site 419947009981 catalytic residues [active] 419947009982 metal binding site [ion binding]; metal-binding site 419947009983 DmpG-like communication domain; Region: DmpG_comm; pfam07836 419947009984 acetaldehyde dehydrogenase; Validated; Region: PRK08300 419947009985 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 419947009986 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 419947009987 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971 419947009988 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 419947009989 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 419947009990 enoyl-CoA hydratase; Region: PLN02864 419947009991 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 419947009992 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 419947009993 dimer interaction site [polypeptide binding]; other site 419947009994 substrate-binding tunnel; other site 419947009995 active site 419947009996 catalytic site [active] 419947009997 substrate binding site [chemical binding]; other site 419947009998 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947009999 PPE family; Region: PPE; pfam00823 419947010000 PE-PPE domain; Region: PE-PPE; pfam08237 419947010001 lipid-transfer protein; Provisional; Region: PRK07855 419947010002 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 419947010003 active site 419947010004 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 419947010005 putative active site [active] 419947010006 putative catalytic site [active] 419947010007 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 419947010008 active site 419947010009 catalytic site [active] 419947010010 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 419947010011 DUF35 OB-fold domain; Region: DUF35; pfam01796 419947010012 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 419947010013 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 419947010014 active site 419947010015 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 419947010016 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 419947010017 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 419947010018 active site 419947010019 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 419947010020 Cytochrome P450; Region: p450; cl12078 419947010021 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 419947010022 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 419947010023 dimer interface [polypeptide binding]; other site 419947010024 active site 419947010025 Domain of unknown function (DUF385); Region: DUF385; pfam04075 419947010026 short chain dehydrogenase; Provisional; Region: PRK07791 419947010027 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 419947010028 homodimer interface [polypeptide binding]; other site 419947010029 NAD binding site [chemical binding]; other site 419947010030 active site 419947010031 short chain dehydrogenase; Provisional; Region: PRK07856 419947010032 classical (c) SDRs; Region: SDR_c; cd05233 419947010033 NAD(P) binding site [chemical binding]; other site 419947010034 active site 419947010035 enoyl-CoA hydratase; Provisional; Region: PRK06495 419947010036 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 419947010037 substrate binding site [chemical binding]; other site 419947010038 oxyanion hole (OAH) forming residues; other site 419947010039 trimer interface [polypeptide binding]; other site 419947010040 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 419947010041 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057 419947010042 Nitronate monooxygenase; Region: NMO; pfam03060 419947010043 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 419947010044 FMN binding site [chemical binding]; other site 419947010045 substrate binding site [chemical binding]; other site 419947010046 putative catalytic residue [active] 419947010047 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 419947010048 Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514 419947010049 putative di-iron ligands [ion binding]; other site 419947010050 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 419947010051 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 419947010052 FAD binding pocket [chemical binding]; other site 419947010053 FAD binding motif [chemical binding]; other site 419947010054 phosphate binding motif [ion binding]; other site 419947010055 beta-alpha-beta structure motif; other site 419947010056 NAD(p) ribose binding residues [chemical binding]; other site 419947010057 NAD binding pocket [chemical binding]; other site 419947010058 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 419947010059 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 419947010060 catalytic loop [active] 419947010061 iron binding site [ion binding]; other site 419947010062 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 419947010063 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 419947010064 putative active site [active] 419947010065 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 419947010066 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 419947010067 dimer interface [polypeptide binding]; other site 419947010068 active site 419947010069 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 419947010070 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 419947010071 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947010072 PPE family; Region: PPE; pfam00823 419947010073 short chain dehydrogenase; Provisional; Region: PRK07831 419947010074 classical (c) SDRs; Region: SDR_c; cd05233 419947010075 NAD(P) binding site [chemical binding]; other site 419947010076 active site 419947010077 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 419947010078 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 419947010079 active site 419947010080 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 419947010081 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 419947010082 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 419947010083 acyl-activating enzyme (AAE) consensus motif; other site 419947010084 putative AMP binding site [chemical binding]; other site 419947010085 putative active site [active] 419947010086 putative CoA binding site [chemical binding]; other site 419947010087 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 419947010088 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 419947010089 active site 419947010090 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 419947010091 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 419947010092 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 419947010093 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 419947010094 active site 419947010095 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 419947010096 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 419947010097 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 419947010098 active site 419947010099 aspartate aminotransferase; Provisional; Region: PRK05764 419947010100 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 419947010101 pyridoxal 5'-phosphate binding site [chemical binding]; other site 419947010102 homodimer interface [polypeptide binding]; other site 419947010103 catalytic residue [active] 419947010104 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 419947010105 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 419947010106 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 419947010107 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 419947010108 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 419947010109 active site 419947010110 Fe binding site [ion binding]; other site 419947010111 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 419947010112 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 419947010113 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 419947010114 Flavin binding site [chemical binding]; other site 419947010115 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 419947010116 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 419947010117 FAD binding pocket [chemical binding]; other site 419947010118 FAD binding motif [chemical binding]; other site 419947010119 phosphate binding motif [ion binding]; other site 419947010120 beta-alpha-beta structure motif; other site 419947010121 NAD(p) ribose binding residues [chemical binding]; other site 419947010122 NAD binding pocket [chemical binding]; other site 419947010123 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 419947010124 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 419947010125 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 419947010126 catalytic loop [active] 419947010127 iron binding site [ion binding]; other site 419947010128 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 419947010129 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 419947010130 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 419947010131 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 419947010132 active site 419947010133 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 419947010134 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 419947010135 Transcriptional regulators [Transcription]; Region: PurR; COG1609 419947010136 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 419947010137 DNA binding site [nucleotide binding] 419947010138 domain linker motif; other site 419947010139 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 419947010140 putative dimerization interface [polypeptide binding]; other site 419947010141 putative ligand binding site [chemical binding]; other site 419947010142 PknH-like extracellular domain; Region: PknH_C; pfam14032 419947010143 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 419947010144 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 419947010145 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 419947010146 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 419947010147 transmembrane helices; other site 419947010148 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 419947010149 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 419947010150 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 419947010151 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 419947010152 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 419947010153 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 419947010154 active site 419947010155 HIGH motif; other site 419947010156 nucleotide binding site [chemical binding]; other site 419947010157 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 419947010158 KMSKS motif; other site 419947010159 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 419947010160 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 419947010161 homotrimer interaction site [polypeptide binding]; other site 419947010162 zinc binding site [ion binding]; other site 419947010163 CDP-binding sites; other site 419947010164 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 419947010165 substrate binding site; other site 419947010166 dimer interface; other site 419947010167 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 419947010168 DNA repair protein RadA; Provisional; Region: PRK11823 419947010169 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 419947010170 Walker A motif/ATP binding site; other site 419947010171 ATP binding site [chemical binding]; other site 419947010172 Walker B motif; other site 419947010173 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 419947010174 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 419947010175 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 419947010176 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 419947010177 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 419947010178 active site clefts [active] 419947010179 zinc binding site [ion binding]; other site 419947010180 dimer interface [polypeptide binding]; other site 419947010181 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 419947010182 endonuclease III; Region: ENDO3c; smart00478 419947010183 minor groove reading motif; other site 419947010184 helix-hairpin-helix signature motif; other site 419947010185 substrate binding pocket [chemical binding]; other site 419947010186 active site 419947010187 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 419947010188 PE family; Region: PE; pfam00934 419947010189 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 419947010190 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 419947010191 catalytic site [active] 419947010192 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 419947010193 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 419947010194 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 419947010195 Ami_2 domain; Region: Ami_2; smart00644 419947010196 amidase catalytic site [active] 419947010197 Zn binding residues [ion binding]; other site 419947010198 substrate binding site [chemical binding]; other site 419947010199 PE family; Region: PE; pfam00934 419947010200 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 419947010201 Clp amino terminal domain; Region: Clp_N; pfam02861 419947010202 Clp amino terminal domain; Region: Clp_N; pfam02861 419947010203 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 419947010204 Walker A motif; other site 419947010205 ATP binding site [chemical binding]; other site 419947010206 Walker B motif; other site 419947010207 arginine finger; other site 419947010208 UvrB/uvrC motif; Region: UVR; pfam02151 419947010209 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 419947010210 Walker A motif; other site 419947010211 ATP binding site [chemical binding]; other site 419947010212 Walker B motif; other site 419947010213 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 419947010214 Lsr2; Region: Lsr2; pfam11774 419947010215 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 419947010216 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 419947010217 dimer interface [polypeptide binding]; other site 419947010218 putative anticodon binding site; other site 419947010219 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 419947010220 motif 1; other site 419947010221 dimer interface [polypeptide binding]; other site 419947010222 active site 419947010223 motif 2; other site 419947010224 motif 3; other site 419947010225 pantothenate kinase; Reviewed; Region: PRK13318 419947010226 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 419947010227 tetramerization interface [polypeptide binding]; other site 419947010228 active site 419947010229 Pantoate-beta-alanine ligase; Region: PanC; cd00560 419947010230 pantoate--beta-alanine ligase; Region: panC; TIGR00018 419947010231 active site 419947010232 ATP-binding site [chemical binding]; other site 419947010233 pantoate-binding site; other site 419947010234 HXXH motif; other site 419947010235 Rossmann-like domain; Region: Rossmann-like; pfam10727 419947010236 Uncharacterized conserved protein [Function unknown]; Region: COG5495 419947010237 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 419947010238 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 419947010239 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 419947010240 catalytic center binding site [active] 419947010241 ATP binding site [chemical binding]; other site 419947010242 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 419947010243 homooctamer interface [polypeptide binding]; other site 419947010244 active site 419947010245 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 419947010246 dihydropteroate synthase; Region: DHPS; TIGR01496 419947010247 substrate binding pocket [chemical binding]; other site 419947010248 dimer interface [polypeptide binding]; other site 419947010249 inhibitor binding site; inhibition site 419947010250 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 419947010251 homodecamer interface [polypeptide binding]; other site 419947010252 GTP cyclohydrolase I; Provisional; Region: PLN03044 419947010253 active site 419947010254 putative catalytic site residues [active] 419947010255 zinc binding site [ion binding]; other site 419947010256 GTP-CH-I/GFRP interaction surface; other site 419947010257 FtsH Extracellular; Region: FtsH_ext; pfam06480 419947010258 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 419947010259 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 419947010260 Walker A motif; other site 419947010261 ATP binding site [chemical binding]; other site 419947010262 Walker B motif; other site 419947010263 arginine finger; other site 419947010264 Peptidase family M41; Region: Peptidase_M41; pfam01434 419947010265 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 419947010266 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 419947010267 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 419947010268 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 419947010269 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 419947010270 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 419947010271 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 419947010272 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947010273 PPE family; Region: PPE; pfam00823 419947010274 PE family; Region: PE; pfam00934 419947010275 Uncharacterized conserved protein [Function unknown]; Region: COG2968 419947010276 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 419947010277 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 419947010278 active site 419947010279 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 419947010280 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 419947010281 Ligand Binding Site [chemical binding]; other site 419947010282 Uncharacterized conserved protein [Function unknown]; Region: COG5282 419947010283 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 419947010284 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113 419947010285 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 419947010286 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 419947010287 dimer interface [polypeptide binding]; other site 419947010288 substrate binding site [chemical binding]; other site 419947010289 metal binding sites [ion binding]; metal-binding site 419947010290 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2899 419947010291 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 419947010292 Ligand binding site; other site 419947010293 Putative Catalytic site; other site 419947010294 DXD motif; other site 419947010295 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 419947010296 Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5285 419947010297 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 419947010298 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 419947010299 NAD(P) binding site [chemical binding]; other site 419947010300 active site 419947010301 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 419947010302 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 419947010303 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 419947010304 transposase; Provisional; Region: PRK06526 419947010305 IstB-like ATP binding protein; Region: IstB_IS21; pfam01695 419947010306 Walker B motif; other site 419947010307 Transposase, Mutator family; Region: Transposase_mut; pfam00872 419947010308 MULE transposase domain; Region: MULE; pfam10551 419947010309 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 419947010310 Fic/DOC family; Region: Fic; cl00960 419947010311 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 419947010312 DNA polymerase III subunit delta'; Validated; Region: PRK07940 419947010313 DNA polymerase III subunit delta'; Validated; Region: PRK08485 419947010314 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 419947010315 dimerization interface [polypeptide binding]; other site 419947010316 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 419947010317 cyclase homology domain; Region: CHD; cd07302 419947010318 nucleotidyl binding site; other site 419947010319 metal binding site [ion binding]; metal-binding site 419947010320 dimer interface [polypeptide binding]; other site 419947010321 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 419947010322 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 419947010323 active site 419947010324 interdomain interaction site; other site 419947010325 putative metal-binding site [ion binding]; other site 419947010326 nucleotide binding site [chemical binding]; other site 419947010327 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 419947010328 domain I; other site 419947010329 phosphate binding site [ion binding]; other site 419947010330 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 419947010331 domain II; other site 419947010332 domain III; other site 419947010333 nucleotide binding site [chemical binding]; other site 419947010334 DNA binding groove [nucleotide binding] 419947010335 catalytic site [active] 419947010336 domain IV; other site 419947010337 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 419947010338 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 419947010339 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 419947010340 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 419947010341 DNA-binding site [nucleotide binding]; DNA binding site 419947010342 RNA-binding motif; other site 419947010343 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 419947010344 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 419947010345 ATP binding site [chemical binding]; other site 419947010346 putative Mg++ binding site [ion binding]; other site 419947010347 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 419947010348 nucleotide binding region [chemical binding]; other site 419947010349 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 419947010350 PE family; Region: PE; pfam00934 419947010351 PE family; Region: PE; pfam00934 419947010352 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 419947010353 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 419947010354 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 419947010355 Walker A motif; other site 419947010356 hexamer interface [polypeptide binding]; other site 419947010357 ATP binding site [chemical binding]; other site 419947010358 Walker B motif; other site 419947010359 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 419947010360 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 419947010361 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 419947010362 motif II; other site 419947010363 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 419947010364 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 419947010365 Walker A/P-loop; other site 419947010366 ATP binding site [chemical binding]; other site 419947010367 Q-loop/lid; other site 419947010368 ABC transporter signature motif; other site 419947010369 Walker B; other site 419947010370 D-loop; other site 419947010371 H-loop/switch region; other site 419947010372 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 419947010373 Walker A/P-loop; other site 419947010374 ATP binding site [chemical binding]; other site 419947010375 Q-loop/lid; other site 419947010376 ABC transporter signature motif; other site 419947010377 Walker B; other site 419947010378 D-loop; other site 419947010379 H-loop/switch region; other site 419947010380 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 419947010381 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 419947010382 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 419947010383 ABC-ATPase subunit interface; other site 419947010384 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 419947010385 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 419947010386 dimer interface [polypeptide binding]; other site 419947010387 conserved gate region; other site 419947010388 ABC-ATPase subunit interface; other site 419947010389 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 419947010390 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 419947010391 acetyl-CoA synthetase; Provisional; Region: PRK00174 419947010392 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 419947010393 active site 419947010394 CoA binding site [chemical binding]; other site 419947010395 acyl-activating enzyme (AAE) consensus motif; other site 419947010396 AMP binding site [chemical binding]; other site 419947010397 acetate binding site [chemical binding]; other site 419947010398 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 419947010399 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 419947010400 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 419947010401 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 419947010402 putative active site [active] 419947010403 putative CoA binding site [chemical binding]; other site 419947010404 nudix motif; other site 419947010405 metal binding site [ion binding]; metal-binding site 419947010406 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 419947010407 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 419947010408 catalytic residues [active] 419947010409 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 419947010410 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 419947010411 minor groove reading motif; other site 419947010412 helix-hairpin-helix signature motif; other site 419947010413 substrate binding pocket [chemical binding]; other site 419947010414 active site 419947010415 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 419947010416 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 419947010417 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 419947010418 ligand binding site [chemical binding]; other site 419947010419 flexible hinge region; other site 419947010420 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 419947010421 putative switch regulator; other site 419947010422 non-specific DNA interactions [nucleotide binding]; other site 419947010423 DNA binding site [nucleotide binding] 419947010424 sequence specific DNA binding site [nucleotide binding]; other site 419947010425 putative cAMP binding site [chemical binding]; other site 419947010426 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 419947010427 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 419947010428 homotrimer interaction site [polypeptide binding]; other site 419947010429 putative active site [active] 419947010430 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 419947010431 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 419947010432 P loop; other site 419947010433 Nucleotide binding site [chemical binding]; other site 419947010434 DTAP/Switch II; other site 419947010435 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 419947010436 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 419947010437 DTAP/Switch II; other site 419947010438 Switch I; other site 419947010439 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 419947010440 Transcription factor WhiB; Region: Whib; pfam02467 419947010441 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 419947010442 Transglycosylase; Region: Transgly; pfam00912 419947010443 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 419947010444 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 419947010445 phosphodiesterase YaeI; Provisional; Region: PRK11340 419947010446 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 419947010447 putative active site [active] 419947010448 putative metal binding site [ion binding]; other site 419947010449 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 419947010450 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 419947010451 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 419947010452 catalytic residue [active] 419947010453 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 419947010454 Cytochrome P450; Region: p450; cl12078 419947010455 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 419947010456 anti sigma factor interaction site; other site 419947010457 regulatory phosphorylation site [posttranslational modification]; other site 419947010458 Uncharacterized conserved protein [Function unknown]; Region: COG1610 419947010459 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 419947010460 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 419947010461 MoxR-like ATPases [General function prediction only]; Region: COG0714 419947010462 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 419947010463 Walker A motif; other site 419947010464 ATP binding site [chemical binding]; other site 419947010465 Walker B motif; other site 419947010466 arginine finger; other site 419947010467 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 419947010468 Protein of unknown function DUF58; Region: DUF58; pfam01882 419947010469 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 419947010470 Predicted membrane protein/domain [Function unknown]; Region: COG1714 419947010471 glycerol kinase; Provisional; Region: glpK; PRK00047 419947010472 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 419947010473 nucleotide binding site [chemical binding]; other site 419947010474 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 419947010475 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 419947010476 Methyltransferase domain; Region: Methyltransf_23; pfam13489 419947010477 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 419947010478 S-adenosylmethionine binding site [chemical binding]; other site 419947010479 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 419947010480 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 419947010481 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 419947010482 catalytic residue [active] 419947010483 Uncharacterized conserved protein [Function unknown]; Region: COG4301 419947010484 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 419947010485 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 419947010486 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 419947010487 putative active site [active] 419947010488 putative dimer interface [polypeptide binding]; other site 419947010489 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 419947010490 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 419947010491 Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG3572 419947010492 PknH-like extracellular domain; Region: PknH_C; pfam14032 419947010493 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 419947010494 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 419947010495 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 419947010496 aspartate kinase; Reviewed; Region: PRK06635 419947010497 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 419947010498 putative nucleotide binding site [chemical binding]; other site 419947010499 putative catalytic residues [active] 419947010500 putative Mg ion binding site [ion binding]; other site 419947010501 putative aspartate binding site [chemical binding]; other site 419947010502 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 419947010503 putative allosteric regulatory site; other site 419947010504 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 419947010505 putative allosteric regulatory residue; other site 419947010506 2-isopropylmalate synthase; Validated; Region: PRK03739 419947010507 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 419947010508 active site 419947010509 catalytic residues [active] 419947010510 metal binding site [ion binding]; metal-binding site 419947010511 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 419947010512 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 419947010513 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 419947010514 active site 419947010515 catalytic site [active] 419947010516 substrate binding site [chemical binding]; other site 419947010517 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 419947010518 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 419947010519 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 419947010520 catalytic triad [active] 419947010521 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 419947010522 putative active site [active] 419947010523 recombination protein RecR; Reviewed; Region: recR; PRK00076 419947010524 RecR protein; Region: RecR; pfam02132 419947010525 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 419947010526 putative active site [active] 419947010527 putative metal-binding site [ion binding]; other site 419947010528 tetramer interface [polypeptide binding]; other site 419947010529 hypothetical protein; Validated; Region: PRK00153 419947010530 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 419947010531 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 419947010532 active site 419947010533 metal binding site [ion binding]; metal-binding site 419947010534 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 419947010535 hydrophobic ligand binding site; other site 419947010536 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 419947010537 FAD binding domain; Region: FAD_binding_4; pfam01565 419947010538 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 419947010539 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 419947010540 S-adenosylmethionine binding site [chemical binding]; other site 419947010541 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14952 419947010542 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 419947010543 Walker A motif; other site 419947010544 ATP binding site [chemical binding]; other site 419947010545 Walker B motif; other site 419947010546 arginine finger; other site 419947010547 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 419947010548 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 419947010549 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 419947010550 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 419947010551 catalytic residue [active] 419947010552 Cutinase; Region: Cutinase; pfam01083 419947010553 Cutinase; Region: Cutinase; pfam01083 419947010554 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 419947010555 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 419947010556 NAD(P) binding site [chemical binding]; other site 419947010557 active site 419947010558 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 419947010559 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 419947010560 putative NAD(P) binding site [chemical binding]; other site 419947010561 catalytic Zn binding site [ion binding]; other site 419947010562 Uncharacterized conserved protein [Function unknown]; Region: COG3349 419947010563 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 419947010564 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 419947010565 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 419947010566 putative substrate translocation pore; other site 419947010567 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 419947010568 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 419947010569 ligand binding site [chemical binding]; other site 419947010570 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 419947010571 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 419947010572 active site 419947010573 nucleophile elbow; other site 419947010574 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 419947010575 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 419947010576 FeS/SAM binding site; other site 419947010577 Methyltransferase domain; Region: Methyltransf_31; pfam13847 419947010578 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 419947010579 S-adenosylmethionine binding site [chemical binding]; other site 419947010580 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 419947010581 nucleotide binding site [chemical binding]; other site 419947010582 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 419947010583 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 419947010584 active site 419947010585 DNA binding site [nucleotide binding] 419947010586 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 419947010587 DNA binding site [nucleotide binding] 419947010588 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4402 419947010589 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_5; cd04662 419947010590 nudix motif; other site 419947010591 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 419947010592 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 419947010593 Uncharacterized conserved protein [Function unknown]; Region: COG1839 419947010594 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 419947010595 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 419947010596 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 419947010597 Uncharacterized conserved protein [Function unknown]; Region: COG2966 419947010598 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 419947010599 Uncharacterized conserved protein [Function unknown]; Region: COG3610 419947010600 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947010601 PPE family; Region: PPE; pfam00823 419947010602 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947010603 PPE family; Region: PPE; pfam00823 419947010604 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 419947010605 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 419947010606 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 419947010607 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 419947010608 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 419947010609 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 419947010610 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 419947010611 Soluble P-type ATPase [General function prediction only]; Region: COG4087 419947010612 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 419947010613 dimerization interface [polypeptide binding]; other site 419947010614 putative DNA binding site [nucleotide binding]; other site 419947010615 putative Zn2+ binding site [ion binding]; other site 419947010616 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3651 419947010617 DNA binding domain, excisionase family; Region: excise; TIGR01764 419947010618 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 419947010619 active site 419947010620 Int/Topo IB signature motif; other site 419947010621 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 419947010622 nucleoside/Zn binding site; other site 419947010623 dimer interface [polypeptide binding]; other site 419947010624 catalytic motif [active] 419947010625 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 419947010626 prephenate dehydrogenase; Validated; Region: PRK06545 419947010627 prephenate dehydrogenase; Validated; Region: PRK08507 419947010628 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3554 419947010629 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 419947010630 ABC-ATPase subunit interface; other site 419947010631 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 419947010632 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 419947010633 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 419947010634 Walker A/P-loop; other site 419947010635 ATP binding site [chemical binding]; other site 419947010636 Q-loop/lid; other site 419947010637 ABC transporter signature motif; other site 419947010638 Walker B; other site 419947010639 D-loop; other site 419947010640 H-loop/switch region; other site 419947010641 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 419947010642 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 419947010643 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 419947010644 putative active site [active] 419947010645 putative substrate binding site [chemical binding]; other site 419947010646 ATP binding site [chemical binding]; other site 419947010647 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 419947010648 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 419947010649 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 419947010650 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 419947010651 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 419947010652 dimerization interface [polypeptide binding]; other site 419947010653 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 419947010654 dimer interface [polypeptide binding]; other site 419947010655 phosphorylation site [posttranslational modification] 419947010656 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 419947010657 ATP binding site [chemical binding]; other site 419947010658 Mg2+ binding site [ion binding]; other site 419947010659 G-X-G motif; other site 419947010660 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 419947010661 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 419947010662 active site 419947010663 phosphorylation site [posttranslational modification] 419947010664 intermolecular recognition site; other site 419947010665 dimerization interface [polypeptide binding]; other site 419947010666 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 419947010667 DNA binding site [nucleotide binding] 419947010668 Photosystem II reaction centre W protein (PsbW); Region: PsbW; cl06243 419947010669 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 419947010670 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 419947010671 SnoaL-like domain; Region: SnoaL_2; pfam12680 419947010672 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 419947010673 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 419947010674 pyridoxal 5'-phosphate binding site [chemical binding]; other site 419947010675 homodimer interface [polypeptide binding]; other site 419947010676 catalytic residue [active] 419947010677 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 419947010678 TIGR03086 family protein; Region: TIGR03086 419947010679 enoyl-CoA hydratase; Provisional; Region: PRK06142 419947010680 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 419947010681 substrate binding site [chemical binding]; other site 419947010682 oxyanion hole (OAH) forming residues; other site 419947010683 trimer interface [polypeptide binding]; other site 419947010684 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 419947010685 Beta-lactamase; Region: Beta-lactamase; pfam00144 419947010686 Domain of unknown function (DUF222); Region: DUF222; pfam02720 419947010687 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 419947010688 active site 419947010689 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 419947010690 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 419947010691 NAD(P) binding site [chemical binding]; other site 419947010692 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 419947010693 cysteine desulfurase family protein, VC1184 subfamily; Region: am_tr_V_VC1184; TIGR01976 419947010694 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 419947010695 catalytic residue [active] 419947010696 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 419947010697 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 419947010698 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 419947010699 Walker A/P-loop; other site 419947010700 ATP binding site [chemical binding]; other site 419947010701 Q-loop/lid; other site 419947010702 ABC transporter signature motif; other site 419947010703 Walker B; other site 419947010704 D-loop; other site 419947010705 H-loop/switch region; other site 419947010706 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 419947010707 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 419947010708 active site 419947010709 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 419947010710 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 419947010711 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 419947010712 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 419947010713 NAD binding site [chemical binding]; other site 419947010714 substrate binding site [chemical binding]; other site 419947010715 active site 419947010716 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 419947010717 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 419947010718 active site 419947010719 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 419947010720 Peptidase family M23; Region: Peptidase_M23; pfam01551 419947010721 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 419947010722 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 419947010723 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05892 419947010724 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 419947010725 Predicted membrane protein [Function unknown]; Region: COG2246 419947010726 GtrA-like protein; Region: GtrA; pfam04138 419947010727 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 419947010728 FAD binding domain; Region: FAD_binding_4; pfam01565 419947010729 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 419947010730 short chain dehydrogenase; Provisional; Region: PRK07904 419947010731 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 419947010732 NAD(P) binding site [chemical binding]; other site 419947010733 active site 419947010734 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 419947010735 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 419947010736 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 419947010737 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 419947010738 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 419947010739 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 419947010740 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 419947010741 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 419947010742 FAD binding site [chemical binding]; other site 419947010743 substrate binding site [chemical binding]; other site 419947010744 catalytic residues [active] 419947010745 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 419947010746 Transposase; Region: DDE_Tnp_ISL3; pfam01610 419947010747 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 419947010748 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 419947010749 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 419947010750 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 419947010751 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 419947010752 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 419947010753 active site 419947010754 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 419947010755 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 419947010756 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 419947010757 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 419947010758 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 419947010759 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 419947010760 acyl-activating enzyme (AAE) consensus motif; other site 419947010761 active site 419947010762 Cutinase; Region: Cutinase; pfam01083 419947010763 Predicted esterase [General function prediction only]; Region: COG0627 419947010764 Putative esterase; Region: Esterase; pfam00756 419947010765 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 419947010766 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 419947010767 active site 419947010768 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 419947010769 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 419947010770 active site 419947010771 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 419947010772 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 419947010773 UDP-galactopyranose mutase; Region: GLF; pfam03275 419947010774 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 419947010775 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 419947010776 amidase catalytic site [active] 419947010777 Zn binding residues [ion binding]; other site 419947010778 substrate binding site [chemical binding]; other site 419947010779 LGFP repeat; Region: LGFP; pfam08310 419947010780 PE family; Region: PE; pfam00934 419947010781 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 419947010782 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 419947010783 active site 419947010784 motif I; other site 419947010785 motif II; other site 419947010786 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 419947010787 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 419947010788 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 419947010789 putative acyl-acceptor binding pocket; other site 419947010790 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 419947010791 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 419947010792 putative acyl-acceptor binding pocket; other site 419947010793 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 419947010794 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 419947010795 putative acyl-acceptor binding pocket; other site 419947010796 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 419947010797 Phosphotransferase enzyme family; Region: APH; pfam01636 419947010798 active site 419947010799 ATP binding site [chemical binding]; other site 419947010800 antibiotic binding site [chemical binding]; other site 419947010801 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 419947010802 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 419947010803 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 419947010804 iron-sulfur cluster [ion binding]; other site 419947010805 [2Fe-2S] cluster binding site [ion binding]; other site 419947010806 Condensation domain; Region: Condensation; pfam00668 419947010807 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 419947010808 PE-PPE domain; Region: PE-PPE; pfam08237 419947010809 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 419947010810 Condensation domain; Region: Condensation; pfam00668 419947010811 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 419947010812 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 419947010813 active site 419947010814 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 419947010815 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 419947010816 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 419947010817 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 419947010818 Enoylreductase; Region: PKS_ER; smart00829 419947010819 NAD(P) binding site [chemical binding]; other site 419947010820 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 419947010821 KR domain; Region: KR; pfam08659 419947010822 putative NADP binding site [chemical binding]; other site 419947010823 active site 419947010824 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 419947010825 acyl-CoA synthetase; Validated; Region: PRK05850 419947010826 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 419947010827 acyl-activating enzyme (AAE) consensus motif; other site 419947010828 active site 419947010829 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 419947010830 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 419947010831 Probable transposase; Region: OrfB_IS605; pfam01385 419947010832 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 419947010833 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 419947010834 catalytic residues [active] 419947010835 catalytic nucleophile [active] 419947010836 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 419947010837 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 419947010838 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 419947010839 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 419947010840 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 419947010841 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 419947010842 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 419947010843 Cupin domain; Region: Cupin_2; cl17218 419947010844 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 419947010845 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 419947010846 seryl-tRNA synthetase; Provisional; Region: PRK05431 419947010847 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 419947010848 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 419947010849 dimer interface [polypeptide binding]; other site 419947010850 active site 419947010851 motif 1; other site 419947010852 motif 2; other site 419947010853 motif 3; other site 419947010854 Septum formation; Region: Septum_form; pfam13845 419947010855 Septum formation; Region: Septum_form; pfam13845 419947010856 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 419947010857 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 419947010858 catalytic core [active] 419947010859 prephenate dehydratase; Provisional; Region: PRK11898 419947010860 Prephenate dehydratase; Region: PDT; pfam00800 419947010861 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 419947010862 putative L-Phe binding site [chemical binding]; other site 419947010863 Transcriptional regulator [Transcription]; Region: LytR; COG1316 419947010864 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 419947010865 Ferritin-like domain; Region: Ferritin; pfam00210 419947010866 ferroxidase diiron center [ion binding]; other site 419947010867 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 419947010868 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 419947010869 putative active site [active] 419947010870 catalytic site [active] 419947010871 putative metal binding site [ion binding]; other site 419947010872 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 419947010873 Transposase; Region: DEDD_Tnp_IS110; pfam01548 419947010874 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 419947010875 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 419947010876 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 419947010877 Predicted membrane protein [Function unknown]; Region: COG2119 419947010878 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 419947010879 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 419947010880 Fimbrial protein; Region: Fimbrial; cl01416 419947010881 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 419947010882 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 419947010883 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 419947010884 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 419947010885 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 419947010886 hypothetical protein; Provisional; Region: PRK07945 419947010887 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 419947010888 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 419947010889 active site 419947010890 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 419947010891 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 419947010892 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 419947010893 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 419947010894 active site 419947010895 dimer interface [polypeptide binding]; other site 419947010896 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 419947010897 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 419947010898 active site 419947010899 FMN binding site [chemical binding]; other site 419947010900 substrate binding site [chemical binding]; other site 419947010901 3Fe-4S cluster binding site [ion binding]; other site 419947010902 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 419947010903 domain interface; other site 419947010904 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 419947010905 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 419947010906 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 419947010907 EspG family; Region: ESX-1_EspG; pfam14011 419947010908 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 419947010909 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 419947010910 Walker A motif; other site 419947010911 ATP binding site [chemical binding]; other site 419947010912 Walker B motif; other site 419947010913 arginine finger; other site 419947010914 Protein of unknown function (DUF690); Region: DUF690; pfam05108 419947010915 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 419947010916 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 419947010917 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 419947010918 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 419947010919 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 419947010920 PE family; Region: PE; pfam00934 419947010921 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 419947010922 PPE family; Region: PPE; pfam00823 419947010923 Proteins of 100 residues with WXG; Region: WXG100; cl02005 419947010924 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 419947010925 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 419947010926 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 419947010927 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 419947010928 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 419947010929 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 419947010930 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 419947010931 active site 419947010932 catalytic residues [active] 419947010933 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 419947010934 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 419947010935 Walker A motif; other site 419947010936 ATP binding site [chemical binding]; other site 419947010937 Walker B motif; other site 419947010938 arginine finger; other site 419947010939 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 419947010940 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 419947010941 catalytic residues [active] 419947010942 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 419947010943 active site 419947010944 catalytic residues [active] 419947010945 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 419947010946 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 419947010947 EspG family; Region: ESX-1_EspG; pfam14011 419947010948 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 419947010949 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 419947010950 PPE family; Region: PPE; pfam00823 419947010951 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 419947010952 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 419947010953 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 419947010954 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 419947010955 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 419947010956 Protein of unknown function (DUF690); Region: DUF690; pfam05108 419947010957 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 419947010958 N-acetyl-D-glucosamine binding site [chemical binding]; other site 419947010959 catalytic residue [active] 419947010960 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 419947010961 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 419947010962 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 419947010963 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 419947010964 active site 419947010965 NTP binding site [chemical binding]; other site 419947010966 metal binding triad [ion binding]; metal-binding site 419947010967 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 419947010968 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 419947010969 Zn2+ binding site [ion binding]; other site 419947010970 Mg2+ binding site [ion binding]; other site 419947010971 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 419947010972 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 419947010973 active site 419947010974 Ap6A binding site [chemical binding]; other site 419947010975 nudix motif; other site 419947010976 metal binding site [ion binding]; metal-binding site 419947010977 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 419947010978 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 419947010979 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 419947010980 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 419947010981 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 419947010982 DNA binding residues [nucleotide binding] 419947010983 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 419947010984 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 419947010985 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 419947010986 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 419947010987 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 419947010988 catalytic residues [active] 419947010989 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 419947010990 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 419947010991 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 419947010992 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 419947010993 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 419947010994 active site 419947010995 metal binding site [ion binding]; metal-binding site 419947010996 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 419947010997 ParB-like nuclease domain; Region: ParB; smart00470 419947010998 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 419947010999 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 419947011000 P-loop; other site 419947011001 Magnesium ion binding site [ion binding]; other site 419947011002 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 419947011003 Magnesium ion binding site [ion binding]; other site 419947011004 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 419947011005 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 419947011006 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 419947011007 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 419947011008 G-X-X-G motif; other site 419947011009 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 419947011010 RxxxH motif; other site 419947011011 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 419947011012 Uncharacterized conserved protein [Function unknown]; Region: COG0759 419947011013 ribonuclease P; Reviewed; Region: rnpA; PRK00588 419947011014 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399