-- dump date 20140619_154637 -- class Genbank::misc_feature -- table misc_feature_note -- id note 83332000001 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 83332000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 83332000003 Walker A motif; other site 83332000004 ATP binding site [chemical binding]; other site 83332000005 Walker B motif; other site 83332000006 arginine finger; other site 83332000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 83332000008 DnaA box-binding interface [nucleotide binding]; other site 83332000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 83332000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 83332000011 putative DNA binding surface [nucleotide binding]; other site 83332000012 dimer interface [polypeptide binding]; other site 83332000013 beta-clamp/clamp loader binding surface; other site 83332000014 beta-clamp/translesion DNA polymerase binding surface; other site 83332000015 recF protein; Region: recf; TIGR00611 83332000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 83332000017 Walker A/P-loop; other site 83332000018 ATP binding site [chemical binding]; other site 83332000019 Q-loop/lid; other site 83332000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 83332000021 ABC transporter signature motif; other site 83332000022 Walker B; other site 83332000023 D-loop; other site 83332000024 H-loop/switch region; other site 83332000025 hypothetical protein; Provisional; Region: PRK03195 83332000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 83332000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 83332000028 Mg2+ binding site [ion binding]; other site 83332000029 G-X-G motif; other site 83332000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 83332000031 anchoring element; other site 83332000032 dimer interface [polypeptide binding]; other site 83332000033 ATP binding site [chemical binding]; other site 83332000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 83332000035 active site 83332000036 putative metal-binding site [ion binding]; other site 83332000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 83332000038 DNA gyrase subunit A; Validated; Region: PRK05560 83332000039 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 83332000040 CAP-like domain; other site 83332000041 active site 83332000042 primary dimer interface [polypeptide binding]; other site 83332000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 83332000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 83332000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 83332000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 83332000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 83332000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 83332000049 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 83332000050 Protein of unknown function (DUF2562); Region: DUF2562; pfam10814 83332000051 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 83332000052 active site 83332000053 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 83332000054 putative septation inhibitor protein; Reviewed; Region: PRK00159 83332000055 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 83332000056 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 83332000057 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 83332000058 Glutamine amidotransferase class-I; Region: GATase; pfam00117 83332000059 glutamine binding [chemical binding]; other site 83332000060 catalytic triad [active] 83332000061 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 83332000062 Catalytic domain of Protein Kinases; Region: PKc; cd00180 83332000063 active site 83332000064 ATP binding site [chemical binding]; other site 83332000065 substrate binding site [chemical binding]; other site 83332000066 activation loop (A-loop); other site 83332000067 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 83332000068 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 83332000069 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 83332000070 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 83332000071 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 83332000072 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 83332000073 Catalytic domain of Protein Kinases; Region: PKc; cd00180 83332000074 active site 83332000075 ATP binding site [chemical binding]; other site 83332000076 substrate binding site [chemical binding]; other site 83332000077 activation loop (A-loop); other site 83332000078 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 83332000079 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 83332000080 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 83332000081 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 83332000082 active site 83332000083 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 83332000084 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 83332000085 phosphopeptide binding site; other site 83332000086 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 83332000087 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 83332000088 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 83332000089 phosphopeptide binding site; other site 83332000090 Nitronate monooxygenase; Region: NMO; pfam03060 83332000091 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 83332000092 FMN binding site [chemical binding]; other site 83332000093 substrate binding site [chemical binding]; other site 83332000094 putative catalytic residue [active] 83332000095 Transcription factor WhiB; Region: Whib; pfam02467 83332000096 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 83332000097 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 83332000098 non-specific DNA binding site [nucleotide binding]; other site 83332000099 salt bridge; other site 83332000100 sequence-specific DNA binding site [nucleotide binding]; other site 83332000101 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 83332000102 NlpC/P60 family; Region: NLPC_P60; pfam00877 83332000103 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 83332000104 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 83332000105 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 83332000106 Protein of unknown function (DUF2694); Region: DUF2694; pfam10904 83332000107 Protein of unknown function (DUF2710); Region: DUF2710; pfam10921 83332000108 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 83332000109 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 83332000110 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 83332000111 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 83332000112 catalytic residue [active] 83332000113 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 83332000114 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 83332000115 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 83332000116 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 83332000117 acyl-activating enzyme (AAE) consensus motif; other site 83332000118 active site 83332000119 TIGR03084 family protein; Region: TIGR03084 83332000120 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 83332000121 Wyosine base formation; Region: Wyosine_form; pfam08608 83332000122 H+ Antiporter protein; Region: 2A0121; TIGR00900 83332000123 hypothetical protein; Validated; Region: PRK00228 83332000124 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 83332000125 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 83332000126 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 83332000127 active site 83332000128 HIGH motif; other site 83332000129 nucleotide binding site [chemical binding]; other site 83332000130 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 83332000131 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 83332000132 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 83332000133 active site 83332000134 KMSKS motif; other site 83332000135 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 83332000136 tRNA binding surface [nucleotide binding]; other site 83332000137 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 83332000138 MarR family; Region: MarR; pfam01047 83332000139 Transcriptional regulators [Transcription]; Region: FadR; COG2186 83332000140 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 83332000141 DNA-binding site [nucleotide binding]; DNA binding site 83332000142 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 83332000143 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 83332000144 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 83332000145 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 83332000146 inositol 1-phosphate synthase, Actinobacterial type; Region: mycothiol_INO1; TIGR03450 83332000147 Predicted transcriptional regulators [Transcription]; Region: COG1695 83332000148 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 83332000149 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 83332000150 Transglycosylase; Region: Transgly; pfam00912 83332000151 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 83332000152 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 83332000153 Predicted integral membrane protein [Function unknown]; Region: COG5650 83332000154 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 83332000155 conserved cys residue [active] 83332000156 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 83332000157 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 83332000158 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 83332000159 dimer interface [polypeptide binding]; other site 83332000160 ssDNA binding site [nucleotide binding]; other site 83332000161 tetramer (dimer of dimers) interface [polypeptide binding]; other site 83332000162 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 83332000163 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 83332000164 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 83332000165 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 83332000166 replicative DNA helicase; Validated; Region: PRK07773 83332000167 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 83332000168 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 83332000169 Walker A motif; other site 83332000170 ATP binding site [chemical binding]; other site 83332000171 Walker B motif; other site 83332000172 DNA binding loops [nucleotide binding] 83332000173 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 83332000174 protein-splicing catalytic site; other site 83332000175 thioester formation/cholesterol transfer; other site 83332000176 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 83332000177 protein-splicing catalytic site; other site 83332000178 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 83332000179 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 83332000180 ADP-ribose binding site [chemical binding]; other site 83332000181 Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1 [General function prediction only]; Region: COG2110 83332000182 Cellobiohydrolase A (1,4-beta-cellobiosidase A) [Carbohydrate transport and metabolism]; Region: CelA; COG5297 83332000183 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 83332000184 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 83332000185 FAD binding domain; Region: FAD_binding_4; pfam01565 83332000186 Berberine and berberine like; Region: BBE; pfam08031 83332000187 hypothetical protein; Provisional; Region: PRK12438 83332000188 hypothetical protein; Validated; Region: PRK00068 83332000189 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 83332000190 homotetrameric interface [polypeptide binding]; other site 83332000191 putative active site [active] 83332000192 metal binding site [ion binding]; metal-binding site 83332000193 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 83332000194 Monomeric isocitrate dehydrogenase; Region: IDH; pfam03971 83332000195 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332000196 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332000197 short chain dehydrogenase; Provisional; Region: PRK06197 83332000198 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 83332000199 putative NAD(P) binding site [chemical binding]; other site 83332000200 active site 83332000201 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 83332000202 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 83332000203 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 83332000204 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 83332000205 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 83332000206 dimer interface [polypeptide binding]; other site 83332000207 active site 83332000208 glycine-pyridoxal phosphate binding site [chemical binding]; other site 83332000209 folate binding site [chemical binding]; other site 83332000210 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 83332000211 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 83332000212 putative NTP binding site [chemical binding]; other site 83332000213 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 83332000214 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 83332000215 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 83332000216 Walker A/P-loop; other site 83332000217 ATP binding site [chemical binding]; other site 83332000218 Q-loop/lid; other site 83332000219 ABC transporter signature motif; other site 83332000220 Walker B; other site 83332000221 D-loop; other site 83332000222 H-loop/switch region; other site 83332000223 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 83332000224 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 83332000225 ligand binding site [chemical binding]; other site 83332000226 flexible hinge region; other site 83332000227 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 83332000228 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 83332000229 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 83332000230 active site 83332000231 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 83332000232 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 83332000233 pyridoxal 5'-phosphate binding site [chemical binding]; other site 83332000234 homodimer interface [polypeptide binding]; other site 83332000235 catalytic residue [active] 83332000236 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 83332000237 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332000238 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332000239 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 83332000240 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 83332000241 dimerization interface [polypeptide binding]; other site 83332000242 putative DNA binding site [nucleotide binding]; other site 83332000243 putative Zn2+ binding site [ion binding]; other site 83332000244 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 83332000245 hydrogenase 4 subunit B; Validated; Region: PRK06521 83332000246 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 83332000247 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 83332000248 NADH dehydrogenase; Region: NADHdh; cl00469 83332000249 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; COG4237 83332000250 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 83332000251 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 83332000252 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 83332000253 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 83332000254 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 83332000255 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 83332000256 putative hydrophobic ligand binding site [chemical binding]; other site 83332000257 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332000258 S-adenosylmethionine binding site [chemical binding]; other site 83332000259 Predicted membrane protein [Function unknown]; Region: COG3305 83332000260 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 83332000261 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 83332000262 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 83332000263 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 83332000264 metal-binding site [ion binding] 83332000265 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 83332000266 Soluble P-type ATPase [General function prediction only]; Region: COG4087 83332000267 Predicted integral membrane protein [Function unknown]; Region: COG5660 83332000268 Putative zinc-finger; Region: zf-HC2; pfam13490 83332000269 Domain of unknown function (DUF222); Region: DUF222; pfam02720 83332000270 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 83332000271 active site 83332000272 Domain of unknown function (DUF222); Region: DUF222; pfam02720 83332000273 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332000274 PPE family; Region: PPE; pfam00823 83332000275 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 83332000276 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 83332000277 FcoT-like thioesterase domain; Region: FcoT; pfam10862 83332000278 acyl-CoA synthetase; Validated; Region: PRK05857 83332000279 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 83332000280 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 83332000281 acyl-activating enzyme (AAE) consensus motif; other site 83332000282 acyl-activating enzyme (AAE) consensus motif; other site 83332000283 AMP binding site [chemical binding]; other site 83332000284 active site 83332000285 CoA binding site [chemical binding]; other site 83332000286 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 83332000287 AMP-binding enzyme; Region: AMP-binding; pfam00501 83332000288 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 83332000289 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 83332000290 acyl-activating enzyme (AAE) consensus motif; other site 83332000291 acyl-activating enzyme (AAE) consensus motif; other site 83332000292 active site 83332000293 AMP binding site [chemical binding]; other site 83332000294 CoA binding site [chemical binding]; other site 83332000295 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 83332000296 Condensation domain; Region: Condensation; pfam00668 83332000297 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 83332000298 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 83332000299 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 83332000300 acyl-activating enzyme (AAE) consensus motif; other site 83332000301 AMP binding site [chemical binding]; other site 83332000302 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 83332000303 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 83332000304 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 83332000305 putative NAD(P) binding site [chemical binding]; other site 83332000306 active site 83332000307 putative substrate binding site [chemical binding]; other site 83332000308 Predicted membrane protein [Function unknown]; Region: COG3336 83332000309 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 83332000310 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 83332000311 metal-binding site [ion binding] 83332000312 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 83332000313 Soluble P-type ATPase [General function prediction only]; Region: COG4087 83332000314 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 83332000315 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 83332000316 ligand binding site [chemical binding]; other site 83332000317 flexible hinge region; other site 83332000318 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 83332000319 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 83332000320 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 83332000321 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 83332000322 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 83332000323 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 83332000324 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 83332000325 motif II; other site 83332000326 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 83332000327 PE family; Region: PE; pfam00934 83332000328 Rhomboid family; Region: Rhomboid; pfam01694 83332000329 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 83332000330 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 83332000331 active site 83332000332 catalytic triad [active] 83332000333 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 83332000334 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 83332000335 NADP-binding site; other site 83332000336 homotetramer interface [polypeptide binding]; other site 83332000337 substrate binding site [chemical binding]; other site 83332000338 homodimer interface [polypeptide binding]; other site 83332000339 active site 83332000340 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 83332000341 dimer interface [polypeptide binding]; other site 83332000342 active site 83332000343 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 83332000344 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 83332000345 active site 83332000346 motif I; other site 83332000347 motif II; other site 83332000348 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 83332000349 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 83332000350 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 83332000351 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 83332000352 Transcriptional regulator [Transcription]; Region: LysR; COG0583 83332000353 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 83332000354 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 83332000355 dimerization interface [polypeptide binding]; other site 83332000356 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 83332000357 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 83332000358 PYR/PP interface [polypeptide binding]; other site 83332000359 dimer interface [polypeptide binding]; other site 83332000360 TPP binding site [chemical binding]; other site 83332000361 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 83332000362 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 83332000363 TPP-binding site; other site 83332000364 dimer interface [polypeptide binding]; other site 83332000365 acyl-CoA synthetase; Validated; Region: PRK05852 83332000366 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 83332000367 Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926 83332000368 acyl-activating enzyme (AAE) consensus motif; other site 83332000369 acyl-activating enzyme (AAE) consensus motif; other site 83332000370 putative AMP binding site [chemical binding]; other site 83332000371 putative active site [active] 83332000372 putative CoA binding site [chemical binding]; other site 83332000373 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 83332000374 elongation factor G; Reviewed; Region: PRK12740 83332000375 G1 box; other site 83332000376 putative GEF interaction site [polypeptide binding]; other site 83332000377 GTP/Mg2+ binding site [chemical binding]; other site 83332000378 Switch I region; other site 83332000379 G2 box; other site 83332000380 G3 box; other site 83332000381 Switch II region; other site 83332000382 G4 box; other site 83332000383 G5 box; other site 83332000384 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 83332000385 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 83332000386 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 83332000387 PPOX class probable F420-dependent enzyme, Rv0121 family; Region: Rv0121_F420; TIGR03668 83332000388 PE family; Region: PE; pfam00934 83332000389 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 83332000390 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 83332000391 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 83332000392 trehalose synthase; Region: treS_nterm; TIGR02456 83332000393 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 83332000394 active site 83332000395 catalytic site [active] 83332000396 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 83332000397 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 83332000398 Predicted membrane protein [Function unknown]; Region: COG3619 83332000399 Predicted esterase [General function prediction only]; Region: COG0627 83332000400 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 83332000401 putative active site [active] 83332000402 putative catalytic site [active] 83332000403 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332000404 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 83332000405 active site 83332000406 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 83332000407 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 83332000408 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 83332000409 Coenzyme A binding pocket [chemical binding]; other site 83332000410 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 83332000411 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 83332000412 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332000413 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332000414 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 83332000415 Cytochrome P450; Region: p450; cl12078 83332000416 methionine sulfoxide reductase A; Provisional; Region: PRK14054 83332000417 SnoaL-like domain; Region: SnoaL_2; pfam12680 83332000418 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 83332000419 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 83332000420 NAD(P) binding site [chemical binding]; other site 83332000421 active site 83332000422 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 83332000423 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 83332000424 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 83332000425 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 83332000426 minor groove reading motif; other site 83332000427 helix-hairpin-helix signature motif; other site 83332000428 active site 83332000429 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 83332000430 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 83332000431 Cl- selectivity filter; other site 83332000432 Cl- binding residues [ion binding]; other site 83332000433 pore gating glutamate residue; other site 83332000434 dimer interface [polypeptide binding]; other site 83332000435 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332000436 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332000437 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 83332000438 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 83332000439 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 83332000440 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 83332000441 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 83332000442 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 83332000443 NAD(P) binding site [chemical binding]; other site 83332000444 catalytic residues [active] 83332000445 short chain dehydrogenase; Provisional; Region: PRK07791 83332000446 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 83332000447 NAD binding site [chemical binding]; other site 83332000448 homodimer interface [polypeptide binding]; other site 83332000449 active site 83332000450 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 83332000451 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 83332000452 NAD(P) binding site [chemical binding]; other site 83332000453 PE family; Region: PE; pfam00934 83332000454 PE-PPE domain; Region: PE-PPE; pfam08237 83332000455 PE-PPE domain; Region: PE-PPE; pfam08237 83332000456 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 83332000457 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 83332000458 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 83332000459 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 83332000460 FAD binding site [chemical binding]; other site 83332000461 substrate binding site [chemical binding]; other site 83332000462 catalytic base [active] 83332000463 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 83332000464 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 83332000465 ligand binding site [chemical binding]; other site 83332000466 homodimer interface [polypeptide binding]; other site 83332000467 NAD(P) binding site [chemical binding]; other site 83332000468 trimer interface B [polypeptide binding]; other site 83332000469 trimer interface A [polypeptide binding]; other site 83332000470 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 83332000471 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 83332000472 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 83332000473 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 83332000474 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332000475 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332000476 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 83332000477 PE family; Region: PE; pfam00934 83332000478 PE-PPE domain; Region: PE-PPE; pfam08237 83332000479 PE family; Region: PE; pfam00934 83332000480 PE-PPE domain; Region: PE-PPE; pfam08237 83332000481 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 83332000482 FAD binding domain; Region: FAD_binding_4; pfam01565 83332000483 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 83332000484 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 83332000485 NAD(P) binding site [chemical binding]; other site 83332000486 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 83332000487 active site 83332000488 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 83332000489 putative hydrophobic ligand binding site [chemical binding]; other site 83332000490 Transcriptional regulators [Transcription]; Region: GntR; COG1802 83332000491 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 83332000492 DNA-binding site [nucleotide binding]; DNA binding site 83332000493 FCD domain; Region: FCD; cl11656 83332000494 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786 83332000495 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 83332000496 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 83332000497 acyl-activating enzyme (AAE) consensus motif; other site 83332000498 acyl-activating enzyme (AAE) consensus motif; other site 83332000499 putative AMP binding site [chemical binding]; other site 83332000500 putative active site [active] 83332000501 putative CoA binding site [chemical binding]; other site 83332000502 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 83332000503 Permease; Region: Permease; pfam02405 83332000504 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 83332000505 Permease; Region: Permease; pfam02405 83332000506 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 83332000507 mce related protein; Region: MCE; pfam02470 83332000508 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 83332000509 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 83332000510 mce related protein; Region: MCE; pfam02470 83332000511 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 83332000512 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 83332000513 mce related protein; Region: MCE; pfam02470 83332000514 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 83332000515 mce related protein; Region: MCE; pfam02470 83332000516 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 83332000517 mce related protein; Region: MCE; pfam02470 83332000518 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 83332000519 mce related protein; Region: MCE; pfam02470 83332000520 RDD family; Region: RDD; pfam06271 83332000521 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 83332000522 Predicted membrane protein [Function unknown]; Region: COG1511 83332000523 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 83332000524 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 83332000525 Pirin-related protein [General function prediction only]; Region: COG1741 83332000526 Pirin; Region: Pirin; pfam02678 83332000527 RNA polymerase factor sigma-70; Validated; Region: PRK08241 83332000528 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 83332000529 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 83332000530 DNA binding residues [nucleotide binding] 83332000531 SnoaL-like domain; Region: SnoaL_2; pfam12680 83332000532 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 83332000533 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 83332000534 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 83332000535 putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185 83332000536 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 83332000537 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 83332000538 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 83332000539 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 83332000540 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 83332000541 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332000542 S-adenosylmethionine binding site [chemical binding]; other site 83332000543 SPW repeat; Region: SPW; pfam03779 83332000544 SPW repeat; Region: SPW; pfam03779 83332000545 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 83332000546 6-phosphogluconate dehydratase; Region: edd; TIGR01196 83332000547 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 83332000548 putative homodimer interface [polypeptide binding]; other site 83332000549 putative homotetramer interface [polypeptide binding]; other site 83332000550 putative allosteric switch controlling residues; other site 83332000551 putative metal binding site [ion binding]; other site 83332000552 putative homodimer-homodimer interface [polypeptide binding]; other site 83332000553 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 83332000554 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 83332000555 putative substrate translocation pore; other site 83332000556 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 83332000557 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 83332000558 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 83332000559 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 83332000560 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 83332000561 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 83332000562 Walker A/P-loop; other site 83332000563 ATP binding site [chemical binding]; other site 83332000564 Q-loop/lid; other site 83332000565 ABC transporter signature motif; other site 83332000566 Walker B; other site 83332000567 D-loop; other site 83332000568 H-loop/switch region; other site 83332000569 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 83332000570 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 83332000571 Walker A/P-loop; other site 83332000572 ATP binding site [chemical binding]; other site 83332000573 Q-loop/lid; other site 83332000574 ABC transporter signature motif; other site 83332000575 Walker B; other site 83332000576 D-loop; other site 83332000577 H-loop/switch region; other site 83332000578 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 83332000579 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 83332000580 dimerization interface [polypeptide binding]; other site 83332000581 DNA binding residues [nucleotide binding] 83332000582 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332000583 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332000584 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 83332000585 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 83332000586 putative [Fe4-S4] binding site [ion binding]; other site 83332000587 putative molybdopterin cofactor binding site [chemical binding]; other site 83332000588 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 83332000589 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 83332000590 putative molybdopterin cofactor binding site; other site 83332000591 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 83332000592 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 83332000593 active site 83332000594 Zn binding site [ion binding]; other site 83332000595 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 83332000596 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 83332000597 Predicted integral membrane protein [Function unknown]; Region: COG0392 83332000598 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 83332000599 Domain of unknown function DUF20; Region: UPF0118; pfam01594 83332000600 MMPL family; Region: MMPL; pfam03176 83332000601 MMPL family; Region: MMPL; pfam03176 83332000602 LabA_like proteins; Region: LabA_like; cd06167 83332000603 putative metal binding site [ion binding]; other site 83332000604 Putative methyltransferase; Region: Methyltransf_4; pfam02390 83332000605 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 83332000606 active site 83332000607 substrate-binding site [chemical binding]; other site 83332000608 metal-binding site [ion binding] 83332000609 GTP binding site [chemical binding]; other site 83332000610 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 83332000611 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 83332000612 active site 83332000613 (T/H)XGH motif; other site 83332000614 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 83332000615 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 83332000616 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 83332000617 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 83332000618 FeS/SAM binding site; other site 83332000619 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 83332000620 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 83332000621 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 83332000622 acyl-activating enzyme (AAE) consensus motif; other site 83332000623 acyl-activating enzyme (AAE) consensus motif; other site 83332000624 putative AMP binding site [chemical binding]; other site 83332000625 putative active site [active] 83332000626 putative CoA binding site [chemical binding]; other site 83332000627 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332000628 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 83332000629 active site 83332000630 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 83332000631 putative active site [active] 83332000632 putative catalytic site [active] 83332000633 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 83332000634 active site 2 [active] 83332000635 active site 1 [active] 83332000636 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 83332000637 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 83332000638 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 83332000639 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321 83332000640 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 83332000641 Moco binding site; other site 83332000642 metal coordination site [ion binding]; other site 83332000643 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 83332000644 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 83332000645 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 83332000646 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 83332000647 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 83332000648 enoyl-CoA hydratase; Provisional; Region: PRK08252 83332000649 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 83332000650 substrate binding site [chemical binding]; other site 83332000651 oxyanion hole (OAH) forming residues; other site 83332000652 trimer interface [polypeptide binding]; other site 83332000653 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 83332000654 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 83332000655 NAD binding site [chemical binding]; other site 83332000656 catalytic residues [active] 83332000657 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332000658 S-adenosylmethionine binding site [chemical binding]; other site 83332000659 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 83332000660 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 83332000661 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 83332000662 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 83332000663 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 83332000664 putative active site [active] 83332000665 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 83332000666 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 83332000667 active site 83332000668 substrate binding pocket [chemical binding]; other site 83332000669 homodimer interaction site [polypeptide binding]; other site 83332000670 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332000671 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 83332000672 active site 83332000673 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332000674 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332000675 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 83332000676 active site 83332000677 diiron metal binding site [ion binding]; other site 83332000678 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 83332000679 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 83332000680 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 83332000681 NAD(P) binding site [chemical binding]; other site 83332000682 catalytic residues [active] 83332000683 Lipase maturation factor; Region: LMF1; pfam06762 83332000684 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 83332000685 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 83332000686 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 83332000687 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 83332000688 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332000689 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332000690 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 83332000691 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 83332000692 MaoC like domain; Region: MaoC_dehydratas; pfam01575 83332000693 active site 2 [active] 83332000694 active site 1 [active] 83332000695 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 83332000696 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 83332000697 NAD(P) binding site [chemical binding]; other site 83332000698 active site 83332000699 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 83332000700 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 83332000701 dimer interface [polypeptide binding]; other site 83332000702 active site 83332000703 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 83332000704 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 83332000705 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 83332000706 FAD binding site [chemical binding]; other site 83332000707 substrate binding site [chemical binding]; other site 83332000708 catalytic residues [active] 83332000709 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 83332000710 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 83332000711 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 83332000712 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 83332000713 catalytic loop [active] 83332000714 iron binding site [ion binding]; other site 83332000715 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 83332000716 L-aspartate oxidase; Provisional; Region: PRK06175 83332000717 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 83332000718 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 83332000719 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 83332000720 putative dimer interface [polypeptide binding]; other site 83332000721 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 83332000722 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 83332000723 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 83332000724 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 83332000725 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 83332000726 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 83332000727 homotrimer interface [polypeptide binding]; other site 83332000728 Walker A motif; other site 83332000729 GTP binding site [chemical binding]; other site 83332000730 Walker B motif; other site 83332000731 cobyric acid synthase; Provisional; Region: PRK00784 83332000732 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 83332000733 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 83332000734 catalytic triad [active] 83332000735 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332000736 PPE family; Region: PPE; pfam00823 83332000737 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 83332000738 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 83332000739 putative active site [active] 83332000740 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 83332000741 putative active site [active] 83332000742 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 83332000743 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 83332000744 active site 83332000745 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 83332000746 DNA binding site [nucleotide binding] 83332000747 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 83332000748 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 83332000749 Coenzyme A binding pocket [chemical binding]; other site 83332000750 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 83332000751 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 83332000752 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 83332000753 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 83332000754 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 83332000755 intersubunit interface [polypeptide binding]; other site 83332000756 5-oxoprolinase; Region: PLN02666 83332000757 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 83332000758 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 83332000759 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 83332000760 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 83332000761 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 83332000762 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 83332000763 nucleotide binding site [chemical binding]; other site 83332000764 acyl-CoA synthetase; Validated; Region: PRK07788 83332000765 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 83332000766 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 83332000767 active site 83332000768 CoA binding site [chemical binding]; other site 83332000769 AMP binding site [chemical binding]; other site 83332000770 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332000771 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 83332000772 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 83332000773 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332000774 FAD binding site [chemical binding]; other site 83332000775 substrate binding site [chemical binding]; other site 83332000776 catalytic base [active] 83332000777 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 83332000778 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332000779 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332000780 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 83332000781 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 83332000782 Zn binding site [ion binding]; other site 83332000783 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 83332000784 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 83332000785 putative active site [active] 83332000786 PE family; Region: PE; pfam00934 83332000787 PE family; Region: PE; pfam00934 83332000788 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332000789 PPE family; Region: PPE; pfam00823 83332000790 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332000791 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 83332000792 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 83332000793 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 83332000794 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 83332000795 Walker A motif; other site 83332000796 ATP binding site [chemical binding]; other site 83332000797 Walker B motif; other site 83332000798 arginine finger; other site 83332000799 Protein of unknown function (DUF690); Region: DUF690; pfam05108 83332000800 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 83332000801 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 83332000802 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 83332000803 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 83332000804 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 83332000805 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332000806 PPE family; Region: PPE; pfam00823 83332000807 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 83332000808 EspG family; Region: ESX-1_EspG; pfam14011 83332000809 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 83332000810 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 83332000811 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 83332000812 active site 83332000813 catalytic residues [active] 83332000814 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 83332000815 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 83332000816 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 83332000817 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 83332000818 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332000819 S-adenosylmethionine binding site [chemical binding]; other site 83332000820 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4424 83332000821 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 83332000822 Sulfatase; Region: Sulfatase; cl17466 83332000823 hypothetical protein; Region: PHA01748 83332000824 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 83332000825 putative active site [active] 83332000826 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332000827 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332000828 light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs; Region: LPOR_like_SDR_c_like; cd09810 83332000829 protochlorophyllide reductase; Region: PLN00015 83332000830 putative NAD(P) binding site [chemical binding]; other site 83332000831 active site 83332000832 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332000833 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332000834 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332000835 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332000836 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332000837 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332000838 PPE family; Region: PPE; pfam00823 83332000839 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332000840 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332000841 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332000842 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332000843 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332000844 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332000845 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332000846 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332000847 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 83332000848 putative FMN binding site [chemical binding]; other site 83332000849 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 83332000850 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 83332000851 active site 83332000852 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 83332000853 SnoaL-like domain; Region: SnoaL_4; pfam13577 83332000854 SnoaL-like domain; Region: SnoaL_3; pfam13474 83332000855 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 83332000856 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 83332000857 nucleotide binding site [chemical binding]; other site 83332000858 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]; Region: HtpG; COG0326 83332000859 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 83332000860 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 83332000861 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 83332000862 active site 83332000863 catalytic residues [active] 83332000864 Muconolactone delta-isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CatC1; COG4829 83332000865 Muconolactone delta-isomerase; Region: MIase; cl01992 83332000866 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 83332000867 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 83332000868 putative active site [active] 83332000869 catalytic site [active] 83332000870 putative metal binding site [ion binding]; other site 83332000871 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 83332000872 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 83332000873 putative substrate binding pocket [chemical binding]; other site 83332000874 AC domain interface; other site 83332000875 catalytic triad [active] 83332000876 AB domain interface; other site 83332000877 interchain disulfide; other site 83332000878 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 83332000879 trimer interface [polypeptide binding]; other site 83332000880 active site 83332000881 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 83332000882 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 83332000883 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 83332000884 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 83332000885 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 83332000886 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 83332000887 dimerization interface [polypeptide binding]; other site 83332000888 putative DNA binding site [nucleotide binding]; other site 83332000889 putative Zn2+ binding site [ion binding]; other site 83332000890 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 83332000891 active site residue [active] 83332000892 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332000893 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 83332000894 Cytochrome P450; Region: p450; cl12078 83332000895 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 83332000896 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332000897 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 83332000898 Methyltransferase domain; Region: Methyltransf_23; pfam13489 83332000899 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332000900 S-adenosylmethionine binding site [chemical binding]; other site 83332000901 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332000902 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332000903 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 83332000904 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 83332000905 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 83332000906 SnoaL-like domain; Region: SnoaL_2; pfam12680 83332000907 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 83332000908 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 83332000909 substrate binding site; other site 83332000910 tetramer interface; other site 83332000911 PE family; Region: PE; pfam00934 83332000912 Domain of unknown function (DUF222); Region: DUF222; pfam02720 83332000913 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 83332000914 active site 83332000915 aminotransferase AlaT; Validated; Region: PRK09265 83332000916 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 83332000917 pyridoxal 5'-phosphate binding site [chemical binding]; other site 83332000918 homodimer interface [polypeptide binding]; other site 83332000919 catalytic residue [active] 83332000920 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 83332000921 4Fe-4S binding domain; Region: Fer4; pfam00037 83332000922 Cysteine-rich domain; Region: CCG; pfam02754 83332000923 Cysteine-rich domain; Region: CCG; pfam02754 83332000924 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 83332000925 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 83332000926 DNA binding residues [nucleotide binding] 83332000927 dimerization interface [polypeptide binding]; other site 83332000928 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 83332000929 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 83332000930 G1 box; other site 83332000931 GTP/Mg2+ binding site [chemical binding]; other site 83332000932 G2 box; other site 83332000933 Switch I region; other site 83332000934 G3 box; other site 83332000935 Switch II region; other site 83332000936 G4 box; other site 83332000937 G5 box; other site 83332000938 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 83332000939 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 83332000940 G1 box; other site 83332000941 GTP/Mg2+ binding site [chemical binding]; other site 83332000942 G2 box; other site 83332000943 Switch I region; other site 83332000944 G3 box; other site 83332000945 Switch II region; other site 83332000946 Uncharacterized MobA-related protein [General function prediction only]; Region: COG2068 83332000947 active site 83332000948 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 83332000949 TIGR04255 family protein; Region: sporadTIGR04255 83332000950 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 83332000951 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 83332000952 nucleotide binding site [chemical binding]; other site 83332000953 NEF interaction site [polypeptide binding]; other site 83332000954 SBD interface [polypeptide binding]; other site 83332000955 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 83332000956 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 83332000957 dimer interface [polypeptide binding]; other site 83332000958 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 83332000959 chaperone protein DnaJ; Provisional; Region: PRK14279 83332000960 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 83332000961 HSP70 interaction site [polypeptide binding]; other site 83332000962 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 83332000963 Zn binding sites [ion binding]; other site 83332000964 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 83332000965 dimer interface [polypeptide binding]; other site 83332000966 Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279 83332000967 DNA binding residues [nucleotide binding] 83332000968 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 83332000969 putative dimer interface [polypeptide binding]; other site 83332000970 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332000971 PPE family; Region: PPE; pfam00823 83332000972 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332000973 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332000974 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332000975 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332000976 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 83332000977 CoenzymeA binding site [chemical binding]; other site 83332000978 subunit interaction site [polypeptide binding]; other site 83332000979 PHB binding site; other site 83332000980 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 83332000981 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 83332000982 GDP-binding site [chemical binding]; other site 83332000983 ACT binding site; other site 83332000984 IMP binding site; other site 83332000985 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 83332000986 Peptidase family M50; Region: Peptidase_M50; pfam02163 83332000987 active site 83332000988 putative substrate binding region [chemical binding]; other site 83332000989 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 83332000990 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 83332000991 MgtE intracellular N domain; Region: MgtE_N; pfam03448 83332000992 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 83332000993 Divalent cation transporter; Region: MgtE; pfam01769 83332000994 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 83332000995 fructose-bisphosphate aldolase, class II, yeast/E. coli subtype; Region: FruBisAldo_II_A; TIGR01520 83332000996 active site 83332000997 intersubunit interface [polypeptide binding]; other site 83332000998 zinc binding site [ion binding]; other site 83332000999 Na+ binding site [ion binding]; other site 83332001000 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 83332001001 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 83332001002 Predicted glycosyl hydrolase [Carbohydrate transport and metabolism]; Region: COG4833 83332001003 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 83332001004 AAA domain; Region: AAA_33; pfam13671 83332001005 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 83332001006 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 83332001007 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 83332001008 putative hydrophobic ligand binding site [chemical binding]; other site 83332001009 MoxR-like ATPases [General function prediction only]; Region: COG0714 83332001010 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 83332001011 Ligand binding site; other site 83332001012 metal-binding site 83332001013 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 83332001014 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 83332001015 XdhC Rossmann domain; Region: XdhC_C; pfam13478 83332001016 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 83332001017 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 83332001018 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 83332001019 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 83332001020 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 83332001021 catalytic loop [active] 83332001022 iron binding site [ion binding]; other site 83332001023 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 83332001024 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 83332001025 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 83332001026 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 83332001027 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 83332001028 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 83332001029 XdhC Rossmann domain; Region: XdhC_C; pfam13478 83332001030 Transcriptional regulator [Transcription]; Region: LysR; COG0583 83332001031 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 83332001032 LysR substrate binding domain; Region: LysR_substrate; pfam03466 83332001033 dimerization interface [polypeptide binding]; other site 83332001034 Uncharacterized conserved protein [Function unknown]; Region: COG3360 83332001035 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 83332001036 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 83332001037 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 83332001038 active site 83332001039 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 83332001040 Clp amino terminal domain; Region: Clp_N; pfam02861 83332001041 Clp amino terminal domain; Region: Clp_N; pfam02861 83332001042 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 83332001043 Walker A motif; other site 83332001044 ATP binding site [chemical binding]; other site 83332001045 Walker B motif; other site 83332001046 arginine finger; other site 83332001047 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 83332001048 Walker A motif; other site 83332001049 ATP binding site [chemical binding]; other site 83332001050 Walker B motif; other site 83332001051 arginine finger; other site 83332001052 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 83332001053 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 83332001054 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 83332001055 heme-binding site [chemical binding]; other site 83332001056 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 83332001057 FAD binding pocket [chemical binding]; other site 83332001058 FAD binding motif [chemical binding]; other site 83332001059 phosphate binding motif [ion binding]; other site 83332001060 beta-alpha-beta structure motif; other site 83332001061 NAD binding pocket [chemical binding]; other site 83332001062 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 83332001063 cyclase homology domain; Region: CHD; cd07302 83332001064 nucleotidyl binding site; other site 83332001065 metal binding site [ion binding]; metal-binding site 83332001066 dimer interface [polypeptide binding]; other site 83332001067 Predicted ATPase [General function prediction only]; Region: COG3903 83332001068 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 83332001069 Walker A motif; other site 83332001070 ATP binding site [chemical binding]; other site 83332001071 Walker B motif; other site 83332001072 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 83332001073 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 83332001074 DNA binding residues [nucleotide binding] 83332001075 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332001076 PPE family; Region: PPE; pfam00823 83332001077 Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase) [Nucleotide transport and metabolism]; Region: PurT; COG0027 83332001078 ATP-grasp domain; Region: ATP-grasp_4; cl17255 83332001079 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 83332001080 active site residue [active] 83332001081 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 83332001082 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 83332001083 homodimer interface [polypeptide binding]; other site 83332001084 substrate-cofactor binding pocket; other site 83332001085 pyridoxal 5'-phosphate binding site [chemical binding]; other site 83332001086 catalytic residue [active] 83332001087 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 83332001088 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 83332001089 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 83332001090 Domain of unknown function (DUF222); Region: DUF222; pfam02720 83332001091 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 83332001092 active site 83332001093 PLD-like domain; Region: PLDc_2; pfam13091 83332001094 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 83332001095 Beta-lactamase; Region: Beta-lactamase; pfam00144 83332001096 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 83332001097 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332001098 FAD binding site [chemical binding]; other site 83332001099 substrate binding pocket [chemical binding]; other site 83332001100 catalytic base [active] 83332001101 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 83332001102 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 83332001103 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 83332001104 acyl-CoA synthetase; Validated; Region: PRK05850 83332001105 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 83332001106 acyl-activating enzyme (AAE) consensus motif; other site 83332001107 active site 83332001108 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 83332001109 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 83332001110 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 83332001111 active site 83332001112 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 83332001113 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 83332001114 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 83332001115 Thioesterase; Region: PKS_TE; smart00824 83332001116 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 83332001117 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 83332001118 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 83332001119 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 83332001120 phosphate acetyltransferase; Reviewed; Region: PRK05632 83332001121 DRTGG domain; Region: DRTGG; pfam07085 83332001122 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 83332001123 propionate/acetate kinase; Provisional; Region: PRK12379 83332001124 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 83332001125 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 83332001126 Catalytic domain of Protein Kinases; Region: PKc; cd00180 83332001127 active site 83332001128 ATP binding site [chemical binding]; other site 83332001129 substrate binding site [chemical binding]; other site 83332001130 activation loop (A-loop); other site 83332001131 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 83332001132 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 83332001133 substrate binding pocket [chemical binding]; other site 83332001134 membrane-bound complex binding site; other site 83332001135 hinge residues; other site 83332001136 NUDIX domain; Region: NUDIX; pfam00293 83332001137 nudix motif; other site 83332001138 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 83332001139 thiamine phosphate binding site [chemical binding]; other site 83332001140 active site 83332001141 pyrophosphate binding site [ion binding]; other site 83332001142 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 83332001143 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 83332001144 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 83332001145 thiS-thiF/thiG interaction site; other site 83332001146 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 83332001147 ThiS interaction site; other site 83332001148 putative active site [active] 83332001149 tetramer interface [polypeptide binding]; other site 83332001150 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 83332001151 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 83332001152 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 83332001153 PA/protease or protease-like domain interface [polypeptide binding]; other site 83332001154 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 83332001155 active site 83332001156 metal binding site [ion binding]; metal-binding site 83332001157 Predicted metalloprotease [General function prediction only]; Region: COG2321 83332001158 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 83332001159 Zn binding site [ion binding]; other site 83332001160 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 83332001161 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 83332001162 dimer interface [polypeptide binding]; other site 83332001163 substrate binding site [chemical binding]; other site 83332001164 ATP binding site [chemical binding]; other site 83332001165 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 83332001166 ThiC-associated domain; Region: ThiC-associated; pfam13667 83332001167 ThiC family; Region: ThiC; pfam01964 83332001168 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 83332001169 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 83332001170 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 83332001171 motif II; other site 83332001172 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 83332001173 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 83332001174 putative catalytic site [active] 83332001175 putative phosphate binding site [ion binding]; other site 83332001176 active site 83332001177 metal binding site A [ion binding]; metal-binding site 83332001178 DNA binding site [nucleotide binding] 83332001179 putative AP binding site [nucleotide binding]; other site 83332001180 putative metal binding site B [ion binding]; other site 83332001181 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 83332001182 active site 83332001183 catalytic residues [active] 83332001184 metal binding site [ion binding]; metal-binding site 83332001185 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 83332001186 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 83332001187 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 83332001188 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 83332001189 E-class dimer interface [polypeptide binding]; other site 83332001190 P-class dimer interface [polypeptide binding]; other site 83332001191 active site 83332001192 Cu2+ binding site [ion binding]; other site 83332001193 Zn2+ binding site [ion binding]; other site 83332001194 carboxylate-amine ligase; Provisional; Region: PRK13517 83332001195 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 83332001196 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 83332001197 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 83332001198 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 83332001199 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 83332001200 Walker A motif; other site 83332001201 ATP binding site [chemical binding]; other site 83332001202 Walker B motif; other site 83332001203 arginine finger; other site 83332001204 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 83332001205 Walker A motif; other site 83332001206 ATP binding site [chemical binding]; other site 83332001207 Walker B motif; other site 83332001208 arginine finger; other site 83332001209 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 83332001210 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 83332001211 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 83332001212 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 83332001213 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 83332001214 dimer interface [polypeptide binding]; other site 83332001215 putative functional site; other site 83332001216 putative MPT binding site; other site 83332001217 short chain dehydrogenase; Provisional; Region: PRK06197 83332001218 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 83332001219 putative NAD(P) binding site [chemical binding]; other site 83332001220 active site 83332001221 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 83332001222 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 83332001223 ring oligomerisation interface [polypeptide binding]; other site 83332001224 ATP/Mg binding site [chemical binding]; other site 83332001225 stacking interactions; other site 83332001226 hinge regions; other site 83332001227 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332001228 PPE family; Region: PPE; pfam00823 83332001229 Protein of unknown function (DUF664); Region: DUF664; pfam04978 83332001230 DinB superfamily; Region: DinB_2; pfam12867 83332001231 putative anti-sigmaE protein; Provisional; Region: PRK13920 83332001232 Anti-sigma-K factor rskA; Region: RskA; pfam10099 83332001233 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 83332001234 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 83332001235 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 83332001236 DNA binding residues [nucleotide binding] 83332001237 Steroid 5-alpha reductase family enzyme [General function prediction only]; Region: COG3752 83332001238 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 83332001239 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332001240 S-adenosylmethionine binding site [chemical binding]; other site 83332001241 Uncharacterized conserved protein [Function unknown]; Region: COG3496 83332001242 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 83332001243 Subunit A of Class III extradiol dioxygenases; Region: Extradiol_Dioxygenase_3A_like; cl06673 83332001244 dimer interface [polypeptide binding]; other site 83332001245 Transport protein; Region: actII; TIGR00833 83332001246 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 83332001247 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332001248 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332001249 PPE family; Region: PPE; pfam00823 83332001250 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332001251 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 83332001252 enoyl-CoA hydratase; Provisional; Region: PRK12478 83332001253 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 83332001254 substrate binding site [chemical binding]; other site 83332001255 oxyanion hole (OAH) forming residues; other site 83332001256 trimer interface [polypeptide binding]; other site 83332001257 PemK-like protein; Region: PemK; pfam02452 83332001258 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 83332001259 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 83332001260 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 83332001261 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 83332001262 NAD(P) binding site [chemical binding]; other site 83332001263 catalytic residues [active] 83332001264 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3564 83332001265 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 83332001266 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 83332001267 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 83332001268 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 83332001269 Uncharacterized conserved protein [Function unknown]; Region: COG2128 83332001270 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 83332001271 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 83332001272 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 83332001273 non-specific DNA binding site [nucleotide binding]; other site 83332001274 salt bridge; other site 83332001275 sequence-specific DNA binding site [nucleotide binding]; other site 83332001276 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 83332001277 Domain of unknown function (DUF955); Region: DUF955; pfam06114 83332001278 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 83332001279 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 83332001280 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 83332001281 active site 83332001282 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 83332001283 active site 2 [active] 83332001284 isocitrate lyase; Provisional; Region: PRK15063 83332001285 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cd06556 83332001286 oligomerization interface [polypeptide binding]; other site 83332001287 active site 83332001288 metal binding site [ion binding]; metal-binding site 83332001289 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 83332001290 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 83332001291 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 83332001292 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 83332001293 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332001294 S-adenosylmethionine binding site [chemical binding]; other site 83332001295 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 83332001296 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 83332001297 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332001298 S-adenosylmethionine binding site [chemical binding]; other site 83332001299 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 83332001300 UbiA prenyltransferase family; Region: UbiA; pfam01040 83332001301 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332001302 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332001303 Predicted membrane protein [Function unknown]; Region: COG2733 83332001304 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 83332001305 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 83332001306 non-specific DNA binding site [nucleotide binding]; other site 83332001307 salt bridge; other site 83332001308 sequence-specific DNA binding site [nucleotide binding]; other site 83332001309 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 83332001310 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 83332001311 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 83332001312 intersubunit interface [polypeptide binding]; other site 83332001313 active site 83332001314 catalytic residue [active] 83332001315 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 83332001316 Predicted amidohydrolase [General function prediction only]; Region: COG0388 83332001317 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 83332001318 putative active site [active] 83332001319 catalytic triad [active] 83332001320 putative dimer interface [polypeptide binding]; other site 83332001321 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 83332001322 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 83332001323 FAD binding domain; Region: FAD_binding_4; pfam01565 83332001324 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 83332001325 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 83332001326 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 83332001327 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 83332001328 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 83332001329 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 83332001330 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 83332001331 NAD(P) binding site [chemical binding]; other site 83332001332 active site 83332001333 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 83332001334 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 83332001335 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 83332001336 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 83332001337 putative ADP-binding pocket [chemical binding]; other site 83332001338 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 83332001339 L-lysine exporter; Region: 2a75; TIGR00948 83332001340 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 83332001341 catalytic core [active] 83332001342 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 83332001343 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 83332001344 dimer interface [polypeptide binding]; other site 83332001345 phosphorylation site [posttranslational modification] 83332001346 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 83332001347 ATP binding site [chemical binding]; other site 83332001348 Mg2+ binding site [ion binding]; other site 83332001349 G-X-G motif; other site 83332001350 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 83332001351 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 83332001352 active site 83332001353 phosphorylation site [posttranslational modification] 83332001354 intermolecular recognition site; other site 83332001355 dimerization interface [polypeptide binding]; other site 83332001356 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 83332001357 DNA binding site [nucleotide binding] 83332001358 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 83332001359 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 83332001360 Transcriptional regulators [Transcription]; Region: FadR; COG2186 83332001361 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 83332001362 DNA-binding site [nucleotide binding]; DNA binding site 83332001363 FCD domain; Region: FCD; pfam07729 83332001364 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 83332001365 exopolyphosphatase; Region: exo_poly_only; TIGR03706 83332001366 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 83332001367 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 83332001368 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 83332001369 Diacylglycerol kinase catalytic domain (presumed); Region: DAGKc; smart00046 83332001370 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 83332001371 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 83332001372 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 83332001373 DNA binding domain, excisionase family; Region: excise; TIGR01764 83332001374 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 83332001375 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 83332001376 putative NAD(P) binding site [chemical binding]; other site 83332001377 active site 83332001378 putative substrate binding site [chemical binding]; other site 83332001379 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 83332001380 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 83332001381 putative acyl-acceptor binding pocket; other site 83332001382 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 83332001383 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 83332001384 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332001385 S-adenosylmethionine binding site [chemical binding]; other site 83332001386 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 83332001387 active site 83332001388 catalytic site [active] 83332001389 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 83332001390 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 83332001391 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 83332001392 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 83332001393 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 83332001394 glutamyl-tRNA reductase; Region: hemA; TIGR01035 83332001395 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 83332001396 tRNA; other site 83332001397 putative tRNA binding site [nucleotide binding]; other site 83332001398 putative NADP binding site [chemical binding]; other site 83332001399 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 83332001400 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 83332001401 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 83332001402 domain interfaces; other site 83332001403 active site 83332001404 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 83332001405 active site 83332001406 homodimer interface [polypeptide binding]; other site 83332001407 SAM binding site [chemical binding]; other site 83332001408 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 83332001409 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 83332001410 active site 83332001411 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 83332001412 dimer interface [polypeptide binding]; other site 83332001413 active site 83332001414 Schiff base residues; other site 83332001415 Domain of unknown function (DUF222); Region: DUF222; pfam02720 83332001416 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 83332001417 active site 83332001418 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 83332001419 anti sigma factor interaction site; other site 83332001420 regulatory phosphorylation site [posttranslational modification]; other site 83332001421 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 83332001422 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 83332001423 active site 83332001424 catalytic triad [active] 83332001425 oxyanion hole [active] 83332001426 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 83332001427 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332001428 Methyltransferase domain; Region: Methyltransf_31; pfam13847 83332001429 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 83332001430 Domain of unknown function (DUF385); Region: DUF385; pfam04075 83332001431 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 83332001432 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 83332001433 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 83332001434 catalytic residue [active] 83332001435 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 83332001436 catalytic core [active] 83332001437 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 83332001438 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 83332001439 catalytic residues [active] 83332001440 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 83332001441 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 83332001442 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 83332001443 ResB-like family; Region: ResB; pfam05140 83332001444 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 83332001445 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 83332001446 AAA domain; Region: AAA_31; pfam13614 83332001447 P-loop; other site 83332001448 Magnesium ion binding site [ion binding]; other site 83332001449 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 83332001450 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 83332001451 3-oxoacyl-(acyl-carrier-protein) synthase III; Region: fabH; TIGR00747 83332001452 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 83332001453 dimer interface [polypeptide binding]; other site 83332001454 active site 83332001455 CoA binding pocket [chemical binding]; other site 83332001456 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 83332001457 UbiA prenyltransferase family; Region: UbiA; pfam01040 83332001458 5'-methylthioadenosine phosphorylase; Validated; Region: PRK07823 83332001459 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 83332001460 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 83332001461 NAD(P) binding site [chemical binding]; other site 83332001462 active site 83332001463 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 83332001464 Ligand binding site; other site 83332001465 Putative Catalytic site; other site 83332001466 DXD motif; other site 83332001467 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3222 83332001468 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 83332001469 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 83332001470 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 83332001471 acyl-activating enzyme (AAE) consensus motif; other site 83332001472 acyl-activating enzyme (AAE) consensus motif; other site 83332001473 AMP binding site [chemical binding]; other site 83332001474 active site 83332001475 CoA binding site [chemical binding]; other site 83332001476 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 83332001477 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 83332001478 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 83332001479 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 83332001480 active site 83332001481 short chain dehydrogenase; Provisional; Region: PRK05866 83332001482 classical (c) SDRs; Region: SDR_c; cd05233 83332001483 NAD(P) binding site [chemical binding]; other site 83332001484 active site 83332001485 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 83332001486 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 83332001487 substrate binding site [chemical binding]; other site 83332001488 oxyanion hole (OAH) forming residues; other site 83332001489 trimer interface [polypeptide binding]; other site 83332001490 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 83332001491 putative active site [active] 83332001492 homotetrameric interface [polypeptide binding]; other site 83332001493 metal binding site [ion binding]; metal-binding site 83332001494 Post-segregation antitoxin (ccd killing mechanism protein) encoded by the F plasmid [General function prediction only]; Region: COG5302 83332001495 acyl-CoA synthetase; Validated; Region: PRK06188 83332001496 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 83332001497 putative active site [active] 83332001498 putative CoA binding site [chemical binding]; other site 83332001499 putative AMP binding site [chemical binding]; other site 83332001500 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 83332001501 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 83332001502 active site 83332001503 O-succinylbenzoate synthase; Provisional; Region: PRK02901 83332001504 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 83332001505 active site 83332001506 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 83332001507 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 83332001508 TAP-like protein; Region: Abhydrolase_4; pfam08386 83332001509 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 83332001510 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 83332001511 dimer interface [polypeptide binding]; other site 83332001512 tetramer interface [polypeptide binding]; other site 83332001513 PYR/PP interface [polypeptide binding]; other site 83332001514 TPP binding site [chemical binding]; other site 83332001515 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 83332001516 TPP-binding site; other site 83332001517 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 83332001518 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 83332001519 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 83332001520 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 83332001521 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332001522 S-adenosylmethionine binding site [chemical binding]; other site 83332001523 Protein of unknown function (DUF732); Region: DUF732; pfam05305 83332001524 Methyltransferase domain; Region: Methyltransf_23; pfam13489 83332001525 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332001526 S-adenosylmethionine binding site [chemical binding]; other site 83332001527 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 83332001528 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 83332001529 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 83332001530 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 83332001531 substrate binding pocket [chemical binding]; other site 83332001532 chain length determination region; other site 83332001533 substrate-Mg2+ binding site; other site 83332001534 catalytic residues [active] 83332001535 aspartate-rich region 1; other site 83332001536 active site lid residues [active] 83332001537 aspartate-rich region 2; other site 83332001538 heat shock protein HtpX; Provisional; Region: PRK03072 83332001539 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439 83332001540 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 83332001541 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 83332001542 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 83332001543 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 83332001544 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 83332001545 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 83332001546 O-methyltransferase; Region: Methyltransf_2; pfam00891 83332001547 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 83332001548 Cytochrome P450; Region: p450; cl12078 83332001549 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 83332001550 ATP cone domain; Region: ATP-cone; pfam03477 83332001551 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 83332001552 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 83332001553 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 83332001554 active site 83332001555 dimer interface [polypeptide binding]; other site 83332001556 effector binding site; other site 83332001557 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 83332001558 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 83332001559 active site 83332001560 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 83332001561 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 83332001562 nicotinate phosphoribosyltransferase; Provisional; Region: PRK12484 83332001563 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 83332001564 active site 83332001565 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 83332001566 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 83332001567 putative active site [active] 83332001568 putative metal binding site [ion binding]; other site 83332001569 hypothetical protein; Provisional; Region: PRK07588 83332001570 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 83332001571 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 83332001572 dimerization interface [polypeptide binding]; other site 83332001573 putative DNA binding site [nucleotide binding]; other site 83332001574 putative Zn2+ binding site [ion binding]; other site 83332001575 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 83332001576 putative hydrophobic ligand binding site [chemical binding]; other site 83332001577 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 83332001578 TIGR03086 family protein; Region: TIGR03086 83332001579 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 83332001580 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 83332001581 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 83332001582 PE family; Region: PE; pfam00934 83332001583 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451 83332001584 Uncharacterized conserved protein [Function unknown]; Region: COG1656 83332001585 Protein of unknown function DUF82; Region: DUF82; pfam01927 83332001586 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 83332001587 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 83332001588 putative active site [active] 83332001589 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 83332001590 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 83332001591 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 83332001592 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 83332001593 Transcriptional regulators [Transcription]; Region: FadR; COG2186 83332001594 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 83332001595 DNA-binding site [nucleotide binding]; DNA binding site 83332001596 FCD domain; Region: FCD; pfam07729 83332001597 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 83332001598 Permease; Region: Permease; pfam02405 83332001599 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 83332001600 Permease; Region: Permease; pfam02405 83332001601 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 83332001602 mce related protein; Region: MCE; pfam02470 83332001603 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 83332001604 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 83332001605 mce related protein; Region: MCE; pfam02470 83332001606 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 83332001607 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 83332001608 mce related protein; Region: MCE; pfam02470 83332001609 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 83332001610 mce related protein; Region: MCE; pfam02470 83332001611 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 83332001612 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 83332001613 mce related protein; Region: MCE; pfam02470 83332001614 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 83332001615 mce related protein; Region: MCE; pfam02470 83332001616 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 83332001617 oligomeric interface; other site 83332001618 putative active site [active] 83332001619 homodimer interface [polypeptide binding]; other site 83332001620 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 83332001621 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 83332001622 AAA domain; Region: AAA_14; pfam13173 83332001623 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 83332001624 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 83332001625 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 83332001626 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 83332001627 ATP binding site [chemical binding]; other site 83332001628 Mg2+ binding site [ion binding]; other site 83332001629 G-X-G motif; other site 83332001630 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 83332001631 dimerization interface [polypeptide binding]; other site 83332001632 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 83332001633 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 83332001634 active site 83332001635 phosphorylation site [posttranslational modification] 83332001636 intermolecular recognition site; other site 83332001637 dimerization interface [polypeptide binding]; other site 83332001638 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 83332001639 DNA binding site [nucleotide binding] 83332001640 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 83332001641 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 83332001642 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 83332001643 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 83332001644 catalytic residues [active] 83332001645 catalytic nucleophile [active] 83332001646 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 83332001647 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 83332001648 Probable transposase; Region: OrfB_IS605; pfam01385 83332001649 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 83332001650 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 83332001651 putative active site [active] 83332001652 SEC-C motif; Region: SEC-C; pfam02810 83332001653 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB-like; cd09875 83332001654 putative active site [active] 83332001655 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 83332001656 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 83332001657 nucleotide binding site/active site [active] 83332001658 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 83332001659 galactokinase; Provisional; Region: PRK00555 83332001660 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 83332001661 Protein of unknown function (DUF732); Region: DUF732; pfam05305 83332001662 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 83332001663 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 83332001664 putative active site [active] 83332001665 Uncharacterized conserved protein [Function unknown]; Region: COG0398 83332001666 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 83332001667 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 83332001668 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 83332001669 oligomeric interface; other site 83332001670 putative active site [active] 83332001671 homodimer interface [polypeptide binding]; other site 83332001672 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 83332001673 FIST N domain; Region: FIST; pfam08495 83332001674 FIST C domain; Region: FIST_C; pfam10442 83332001675 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 83332001676 AAA domain; Region: AAA_30; pfam13604 83332001677 Family description; Region: UvrD_C_2; pfam13538 83332001678 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 83332001679 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 83332001680 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 83332001681 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 83332001682 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 83332001683 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 83332001684 substrate binding site [chemical binding]; other site 83332001685 oxyanion hole (OAH) forming residues; other site 83332001686 trimer interface [polypeptide binding]; other site 83332001687 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 83332001688 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 83332001689 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 83332001690 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 83332001691 active site 83332001692 catalytic site [active] 83332001693 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 83332001694 active site 83332001695 catalytic site [active] 83332001696 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 83332001697 active site 83332001698 catalytic site [active] 83332001699 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 83332001700 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 83332001701 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 83332001702 putative homodimer interface [polypeptide binding]; other site 83332001703 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 83332001704 heterodimer interface [polypeptide binding]; other site 83332001705 homodimer interface [polypeptide binding]; other site 83332001706 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 83332001707 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 83332001708 23S rRNA interface [nucleotide binding]; other site 83332001709 L7/L12 interface [polypeptide binding]; other site 83332001710 putative thiostrepton binding site; other site 83332001711 L25 interface [polypeptide binding]; other site 83332001712 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 83332001713 mRNA/rRNA interface [nucleotide binding]; other site 83332001714 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 83332001715 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332001716 S-adenosylmethionine binding site [chemical binding]; other site 83332001717 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 83332001718 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 83332001719 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332001720 S-adenosylmethionine binding site [chemical binding]; other site 83332001721 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 83332001722 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 83332001723 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332001724 S-adenosylmethionine binding site [chemical binding]; other site 83332001725 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 83332001726 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 83332001727 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332001728 S-adenosylmethionine binding site [chemical binding]; other site 83332001729 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 83332001730 TAP-like protein; Region: Abhydrolase_4; pfam08386 83332001731 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 83332001732 ABC1 family; Region: ABC1; cl17513 83332001733 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 83332001734 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 83332001735 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 83332001736 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 83332001737 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 83332001738 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 83332001739 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 83332001740 23S rRNA interface [nucleotide binding]; other site 83332001741 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 83332001742 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 83332001743 core dimer interface [polypeptide binding]; other site 83332001744 peripheral dimer interface [polypeptide binding]; other site 83332001745 L10 interface [polypeptide binding]; other site 83332001746 L11 interface [polypeptide binding]; other site 83332001747 putative EF-Tu interaction site [polypeptide binding]; other site 83332001748 putative EF-G interaction site [polypeptide binding]; other site 83332001749 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332001750 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332001751 WHG domain; Region: WHG; pfam13305 83332001752 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 83332001753 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 83332001754 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 83332001755 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 83332001756 Walker A/P-loop; other site 83332001757 ATP binding site [chemical binding]; other site 83332001758 Q-loop/lid; other site 83332001759 ABC transporter signature motif; other site 83332001760 Walker B; other site 83332001761 D-loop; other site 83332001762 H-loop/switch region; other site 83332001763 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 83332001764 putative active site [active] 83332001765 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 83332001766 CAAX protease self-immunity; Region: Abi; pfam02517 83332001767 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 83332001768 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG1848 83332001769 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 83332001770 Sulfatase; Region: Sulfatase; pfam00884 83332001771 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 83332001772 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 83332001773 putative active site [active] 83332001774 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 83332001775 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 83332001776 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 83332001777 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 83332001778 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 83332001779 RPB10 interaction site [polypeptide binding]; other site 83332001780 RPB1 interaction site [polypeptide binding]; other site 83332001781 RPB11 interaction site [polypeptide binding]; other site 83332001782 RPB3 interaction site [polypeptide binding]; other site 83332001783 RPB12 interaction site [polypeptide binding]; other site 83332001784 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 83332001785 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 83332001786 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 83332001787 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 83332001788 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 83332001789 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 83332001790 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 83332001791 G-loop; other site 83332001792 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 83332001793 DNA binding site [nucleotide binding] 83332001794 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 83332001795 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; pfam04734 83332001796 endonuclease IV; Provisional; Region: PRK01060 83332001797 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 83332001798 AP (apurinic/apyrimidinic) site pocket; other site 83332001799 DNA interaction; other site 83332001800 Metal-binding active site; metal-binding site 83332001801 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 83332001802 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 83332001803 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 83332001804 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 83332001805 active site 83332001806 enoyl-CoA hydratase; Provisional; Region: PRK12478 83332001807 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 83332001808 substrate binding site [chemical binding]; other site 83332001809 oxyanion hole (OAH) forming residues; other site 83332001810 trimer interface [polypeptide binding]; other site 83332001811 Phenylacetic acid-responsive transcriptional repressor [Transcription]; Region: PaaX; COG3327 83332001812 PaaX-like protein; Region: PaaX; pfam07848 83332001813 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 83332001814 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 83332001815 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 83332001816 substrate binding site [chemical binding]; other site 83332001817 oxyanion hole (OAH) forming residues; other site 83332001818 trimer interface [polypeptide binding]; other site 83332001819 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 83332001820 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 83332001821 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 83332001822 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 83332001823 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332001824 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332001825 WHG domain; Region: WHG; pfam13305 83332001826 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 83332001827 S17 interaction site [polypeptide binding]; other site 83332001828 S8 interaction site; other site 83332001829 16S rRNA interaction site [nucleotide binding]; other site 83332001830 streptomycin interaction site [chemical binding]; other site 83332001831 23S rRNA interaction site [nucleotide binding]; other site 83332001832 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 83332001833 30S ribosomal protein S7; Validated; Region: PRK05302 83332001834 elongation factor G; Reviewed; Region: PRK00007 83332001835 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 83332001836 G1 box; other site 83332001837 putative GEF interaction site [polypeptide binding]; other site 83332001838 GTP/Mg2+ binding site [chemical binding]; other site 83332001839 Switch I region; other site 83332001840 G2 box; other site 83332001841 G3 box; other site 83332001842 Switch II region; other site 83332001843 G4 box; other site 83332001844 G5 box; other site 83332001845 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 83332001846 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 83332001847 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 83332001848 elongation factor Tu; Reviewed; Region: PRK00049 83332001849 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 83332001850 G1 box; other site 83332001851 GEF interaction site [polypeptide binding]; other site 83332001852 GTP/Mg2+ binding site [chemical binding]; other site 83332001853 Switch I region; other site 83332001854 G2 box; other site 83332001855 G3 box; other site 83332001856 Switch II region; other site 83332001857 G4 box; other site 83332001858 G5 box; other site 83332001859 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 83332001860 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 83332001861 Antibiotic Binding Site [chemical binding]; other site 83332001862 Short C-terminal domain; Region: SHOCT; pfam09851 83332001863 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 83332001864 classical (c) SDRs; Region: SDR_c; cd05233 83332001865 NAD(P) binding site [chemical binding]; other site 83332001866 active site 83332001867 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 83332001868 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 83332001869 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4427 83332001870 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 83332001871 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332001872 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 83332001873 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 83332001874 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 83332001875 FeS/SAM binding site; other site 83332001876 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 83332001877 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 83332001878 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 83332001879 phosphate binding site [ion binding]; other site 83332001880 mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964 83332001881 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 83332001882 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 83332001883 Probable Catalytic site; other site 83332001884 metal-binding site 83332001885 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 83332001886 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 83332001887 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 83332001888 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 83332001889 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 83332001890 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 83332001891 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 83332001892 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 83332001893 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 83332001894 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 83332001895 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 83332001896 putative translocon binding site; other site 83332001897 protein-rRNA interface [nucleotide binding]; other site 83332001898 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 83332001899 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 83332001900 G-X-X-G motif; other site 83332001901 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 83332001902 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 83332001903 23S rRNA interface [nucleotide binding]; other site 83332001904 5S rRNA interface [nucleotide binding]; other site 83332001905 putative antibiotic binding site [chemical binding]; other site 83332001906 L25 interface [polypeptide binding]; other site 83332001907 L27 interface [polypeptide binding]; other site 83332001908 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 83332001909 putative translocon interaction site; other site 83332001910 23S rRNA interface [nucleotide binding]; other site 83332001911 signal recognition particle (SRP54) interaction site; other site 83332001912 L23 interface [polypeptide binding]; other site 83332001913 trigger factor interaction site; other site 83332001914 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 83332001915 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 83332001916 Sulfatase; Region: Sulfatase; pfam00884 83332001917 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353 83332001918 Uncharacterized conserved protein [Function unknown]; Region: COG1262 83332001919 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 83332001920 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 83332001921 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 83332001922 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 83332001923 RNA binding site [nucleotide binding]; other site 83332001924 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 83332001925 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 83332001926 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 83332001927 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 83332001928 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 83332001929 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 83332001930 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 83332001931 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 83332001932 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 83332001933 5S rRNA interface [nucleotide binding]; other site 83332001934 23S rRNA interface [nucleotide binding]; other site 83332001935 L5 interface [polypeptide binding]; other site 83332001936 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 83332001937 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 83332001938 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 83332001939 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 83332001940 23S rRNA binding site [nucleotide binding]; other site 83332001941 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 83332001942 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 83332001943 tandem repeat interface [polypeptide binding]; other site 83332001944 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 83332001945 oligomer interface [polypeptide binding]; other site 83332001946 active site residues [active] 83332001947 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 83332001948 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 83332001949 tandem repeat interface [polypeptide binding]; other site 83332001950 oligomer interface [polypeptide binding]; other site 83332001951 active site residues [active] 83332001952 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 83332001953 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 83332001954 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 83332001955 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 83332001956 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 83332001957 intersubunit interface [polypeptide binding]; other site 83332001958 active site 83332001959 Zn2+ binding site [ion binding]; other site 83332001960 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 83332001961 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 83332001962 NAD binding site [chemical binding]; other site 83332001963 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 83332001964 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 83332001965 nucleotide binding site [chemical binding]; other site 83332001966 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 83332001967 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 83332001968 Coenzyme A binding pocket [chemical binding]; other site 83332001969 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 83332001970 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 83332001971 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 83332001972 SecY translocase; Region: SecY; pfam00344 83332001973 adenylate kinase; Reviewed; Region: adk; PRK00279 83332001974 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 83332001975 AMP-binding site [chemical binding]; other site 83332001976 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 83332001977 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 83332001978 active site 83332001979 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 83332001980 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 83332001981 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 83332001982 DNA binding residues [nucleotide binding] 83332001983 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 83332001984 Putative zinc-finger; Region: zf-HC2; pfam13490 83332001985 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 83332001986 MarR family; Region: MarR; pfam01047 83332001987 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 83332001988 TIGR03086 family protein; Region: TIGR03086 83332001989 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 83332001990 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 83332001991 Transposase; Region: DDE_Tnp_ISL3; pfam01610 83332001992 Helix-turn-helix domain; Region: HTH_17; pfam12728 83332001993 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 83332001994 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 83332001995 PE family; Region: PE; pfam00934 83332001996 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 83332001997 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 83332001998 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 83332001999 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 83332002000 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332002001 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 83332002002 active site 83332002003 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 83332002004 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 83332002005 tetrameric interface [polypeptide binding]; other site 83332002006 NAD binding site [chemical binding]; other site 83332002007 catalytic residues [active] 83332002008 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 83332002009 catalytic core [active] 83332002010 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332002011 PPE family; Region: PPE; pfam00823 83332002012 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332002013 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332002014 Helix-turn-helix domain; Region: HTH_28; pfam13518 83332002015 Winged helix-turn helix; Region: HTH_29; pfam13551 83332002016 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 83332002017 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 83332002018 active site 83332002019 phosphorylation site [posttranslational modification] 83332002020 intermolecular recognition site; other site 83332002021 dimerization interface [polypeptide binding]; other site 83332002022 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 83332002023 DNA binding site [nucleotide binding] 83332002024 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 83332002025 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 83332002026 dimerization interface [polypeptide binding]; other site 83332002027 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 83332002028 dimer interface [polypeptide binding]; other site 83332002029 phosphorylation site [posttranslational modification] 83332002030 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 83332002031 ATP binding site [chemical binding]; other site 83332002032 Mg2+ binding site [ion binding]; other site 83332002033 G-X-G motif; other site 83332002034 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 83332002035 nucleotide binding site/active site [active] 83332002036 HIT family signature motif; other site 83332002037 catalytic residue [active] 83332002038 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 83332002039 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 83332002040 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 83332002041 NAD binding site [chemical binding]; other site 83332002042 catalytic Zn binding site [ion binding]; other site 83332002043 substrate binding site [chemical binding]; other site 83332002044 structural Zn binding site [ion binding]; other site 83332002045 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 83332002046 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 83332002047 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 83332002048 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 83332002049 Cytochrome P450; Region: p450; cl12078 83332002050 short chain dehydrogenase; Provisional; Region: PRK07775 83332002051 classical (c) SDRs; Region: SDR_c; cd05233 83332002052 NAD(P) binding site [chemical binding]; other site 83332002053 active site 83332002054 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 83332002055 Cytochrome P450; Region: p450; cl12078 83332002056 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332002057 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 83332002058 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 83332002059 NAD binding site [chemical binding]; other site 83332002060 catalytic residues [active] 83332002061 short chain dehydrogenase; Provisional; Region: PRK07774 83332002062 classical (c) SDRs; Region: SDR_c; cd05233 83332002063 NAD(P) binding site [chemical binding]; other site 83332002064 active site 83332002065 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 83332002066 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 83332002067 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 83332002068 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 83332002069 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 83332002070 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 83332002071 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 83332002072 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 83332002073 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 83332002074 Predicted esterase [General function prediction only]; Region: COG0627 83332002075 S-formylglutathione hydrolase; Region: PLN02442 83332002076 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 83332002077 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 83332002078 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 83332002079 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 83332002080 tetramer interface [polypeptide binding]; other site 83332002081 active site 83332002082 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 83332002083 Cytochrome P450; Region: p450; cl12078 83332002084 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 83332002085 ATP binding site [chemical binding]; other site 83332002086 active site 83332002087 substrate binding site [chemical binding]; other site 83332002088 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 83332002089 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 83332002090 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 83332002091 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 83332002092 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 83332002093 putative substrate translocation pore; other site 83332002094 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 83332002095 Predicted deacetylase [General function prediction only]; Region: COG3233 83332002096 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 83332002097 putative active site [active] 83332002098 putative Zn binding site [ion binding]; other site 83332002099 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 83332002100 FAD binding domain; Region: FAD_binding_2; pfam00890 83332002101 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 83332002102 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 83332002103 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 83332002104 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 83332002105 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 83332002106 putative active site [active] 83332002107 catalytic triad [active] 83332002108 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 83332002109 Transglutaminase/protease-like homologues; Region: TGc; smart00460 83332002110 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 83332002111 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 83332002112 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 83332002113 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 83332002114 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 83332002115 DNA-binding site [nucleotide binding]; DNA binding site 83332002116 UTRA domain; Region: UTRA; pfam07702 83332002117 Uncharacterized conserved protein [Function unknown]; Region: COG1359 83332002118 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 83332002119 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 83332002120 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 83332002121 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 83332002122 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 83332002123 Transposase; Region: HTH_Tnp_1; cl17663 83332002124 putative transposase OrfB; Reviewed; Region: PHA02517 83332002125 HTH-like domain; Region: HTH_21; pfam13276 83332002126 Integrase core domain; Region: rve; pfam00665 83332002127 Integrase core domain; Region: rve_3; pfam13683 83332002128 Transposase; Region: DEDD_Tnp_IS110; pfam01548 83332002129 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 83332002130 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 83332002131 Uncharacterized protein, linocin/CFP29 homolog [Function unknown]; Region: COG1659 83332002132 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 83332002133 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 83332002134 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 83332002135 active site 83332002136 metal binding site [ion binding]; metal-binding site 83332002137 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 83332002138 active site 83332002139 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 83332002140 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 83332002141 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 83332002142 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 83332002143 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 83332002144 dimerization interface [polypeptide binding]; other site 83332002145 ATP binding site [chemical binding]; other site 83332002146 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 83332002147 dimerization interface [polypeptide binding]; other site 83332002148 ATP binding site [chemical binding]; other site 83332002149 CAAX protease self-immunity; Region: Abi; pfam02517 83332002150 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 83332002151 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 83332002152 active site 83332002153 metal binding site [ion binding]; metal-binding site 83332002154 hexamer interface [polypeptide binding]; other site 83332002155 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 83332002156 amidophosphoribosyltransferase; Provisional; Region: PRK07847 83332002157 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 83332002158 active site 83332002159 tetramer interface [polypeptide binding]; other site 83332002160 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 83332002161 active site 83332002162 phosphoribosylaminoimidazole synthetase; Region: purM; TIGR00878 83332002163 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 83332002164 dimerization interface [polypeptide binding]; other site 83332002165 putative ATP binding site [chemical binding]; other site 83332002166 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 83332002167 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 83332002168 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 83332002169 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 83332002170 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 83332002171 pyridoxal 5'-phosphate binding site [chemical binding]; other site 83332002172 catalytic residue [active] 83332002173 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 83332002174 heme-binding site [chemical binding]; other site 83332002175 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 83332002176 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 83332002177 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 83332002178 active site residue [active] 83332002179 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 83332002180 active site residue [active] 83332002181 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 83332002182 catalytic residues [active] 83332002183 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 83332002184 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 83332002185 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 83332002186 DNA binding site [nucleotide binding] 83332002187 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 83332002188 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 83332002189 Coenzyme A binding pocket [chemical binding]; other site 83332002190 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 83332002191 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 83332002192 Walker A/P-loop; other site 83332002193 ATP binding site [chemical binding]; other site 83332002194 Q-loop/lid; other site 83332002195 ABC transporter signature motif; other site 83332002196 Walker B; other site 83332002197 D-loop; other site 83332002198 H-loop/switch region; other site 83332002199 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 83332002200 PhoU domain; Region: PhoU; pfam01895 83332002201 PhoU domain; Region: PhoU; pfam01895 83332002202 cell envelope-related function transcriptional attenuator common domain; Region: lytR_cpsA_psr; TIGR00350 83332002203 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 83332002204 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 83332002205 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 83332002206 FMN binding site [chemical binding]; other site 83332002207 active site 83332002208 catalytic residues [active] 83332002209 substrate binding site [chemical binding]; other site 83332002210 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 83332002211 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 83332002212 homodimer interface [polypeptide binding]; other site 83332002213 putative substrate binding pocket [chemical binding]; other site 83332002214 diiron center [ion binding]; other site 83332002215 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332002216 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 83332002217 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 83332002218 dimerization interface [polypeptide binding]; other site 83332002219 putative DNA binding site [nucleotide binding]; other site 83332002220 putative Zn2+ binding site [ion binding]; other site 83332002221 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 83332002222 dimer interface [polypeptide binding]; other site 83332002223 catalytic motif [active] 83332002224 nucleoside/Zn binding site; other site 83332002225 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 83332002226 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 83332002227 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 83332002228 TIGR04255 family protein; Region: sporadTIGR04255 83332002229 PE family; Region: PE; pfam00934 83332002230 PE family; Region: PE; pfam00934 83332002231 PknH-like extracellular domain; Region: PknH_C; pfam14032 83332002232 Predicted nucleotidyltransferase [General function prediction only]; Region: COG4849 83332002233 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4861 83332002234 Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952 83332002235 D-ala-D-ala dipeptidase; Region: Peptidase_M15; pfam01427 83332002236 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332002237 S-adenosylmethionine binding site [chemical binding]; other site 83332002238 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 83332002239 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 83332002240 putative substrate translocation pore; other site 83332002241 Major Facilitator Superfamily; Region: MFS_1; pfam07690 83332002242 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 83332002243 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 83332002244 tetramer interface [polypeptide binding]; other site 83332002245 TPP-binding site [chemical binding]; other site 83332002246 heterodimer interface [polypeptide binding]; other site 83332002247 phosphorylation loop region [posttranslational modification] 83332002248 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 83332002249 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 83332002250 active site 83332002251 phosphorylation site [posttranslational modification] 83332002252 intermolecular recognition site; other site 83332002253 dimerization interface [polypeptide binding]; other site 83332002254 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 83332002255 DNA binding residues [nucleotide binding] 83332002256 dimerization interface [polypeptide binding]; other site 83332002257 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 83332002258 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 83332002259 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 83332002260 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 83332002261 Multicopper oxidase; Region: Cu-oxidase; pfam00394 83332002262 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 83332002263 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 83332002264 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 83332002265 dimer interface [polypeptide binding]; other site 83332002266 pyridoxal 5'-phosphate binding site [chemical binding]; other site 83332002267 catalytic residue [active] 83332002268 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 83332002269 multidrug resistance protein MdtH; Provisional; Region: PRK11646 83332002270 putative substrate translocation pore; other site 83332002271 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 83332002272 short chain dehydrogenase; Provisional; Region: PRK05876 83332002273 classical (c) SDRs; Region: SDR_c; cd05233 83332002274 NAD(P) binding site [chemical binding]; other site 83332002275 active site 83332002276 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 83332002277 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 83332002278 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 83332002279 dimer interface [polypeptide binding]; other site 83332002280 PYR/PP interface [polypeptide binding]; other site 83332002281 TPP binding site [chemical binding]; other site 83332002282 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 83332002283 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 83332002284 TPP-binding site [chemical binding]; other site 83332002285 dimer interface [polypeptide binding]; other site 83332002286 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 83332002287 putative hydrophobic ligand binding site [chemical binding]; other site 83332002288 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 83332002289 CoA-transferase family III; Region: CoA_transf_3; pfam02515 83332002290 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 83332002291 putative hydrophobic ligand binding site [chemical binding]; other site 83332002292 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 83332002293 putative hydrophobic ligand binding site [chemical binding]; other site 83332002294 aminotransferase; Validated; Region: PRK07777 83332002295 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 83332002296 pyridoxal 5'-phosphate binding site [chemical binding]; other site 83332002297 homodimer interface [polypeptide binding]; other site 83332002298 catalytic residue [active] 83332002299 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 83332002300 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 83332002301 dimer interface [polypeptide binding]; other site 83332002302 active site 83332002303 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 83332002304 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 83332002305 substrate binding site [chemical binding]; other site 83332002306 oxyanion hole (OAH) forming residues; other site 83332002307 trimer interface [polypeptide binding]; other site 83332002308 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 83332002309 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 83332002310 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 83332002311 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 83332002312 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 83332002313 ATP binding site [chemical binding]; other site 83332002314 putative Mg++ binding site [ion binding]; other site 83332002315 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 83332002316 nucleotide binding region [chemical binding]; other site 83332002317 ATP-binding site [chemical binding]; other site 83332002318 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 83332002319 WYL domain; Region: WYL; pfam13280 83332002320 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 83332002321 trimer interface [polypeptide binding]; other site 83332002322 dimer interface [polypeptide binding]; other site 83332002323 putative active site [active] 83332002324 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 83332002325 MPT binding site; other site 83332002326 trimer interface [polypeptide binding]; other site 83332002327 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 83332002328 MoaE homodimer interface [polypeptide binding]; other site 83332002329 MoaD interaction [polypeptide binding]; other site 83332002330 active site residues [active] 83332002331 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 83332002332 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 83332002333 MoaE interaction surface [polypeptide binding]; other site 83332002334 MoeB interaction surface [polypeptide binding]; other site 83332002335 thiocarboxylated glycine; other site 83332002336 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 83332002337 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 83332002338 FeS/SAM binding site; other site 83332002339 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 83332002340 hypothetical protein; Provisional; Region: PRK11770 83332002341 Domain of unknown function (DUF307); Region: DUF307; pfam03733 83332002342 Domain of unknown function (DUF307); Region: DUF307; pfam03733 83332002343 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 83332002344 DNA-binding site [nucleotide binding]; DNA binding site 83332002345 RNA-binding motif; other site 83332002346 PE family; Region: PE; pfam00934 83332002347 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 83332002348 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332002349 active site 83332002350 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 83332002351 FIST N domain; Region: FIST; pfam08495 83332002352 FIST C domain; Region: FIST_C; pfam10442 83332002353 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 83332002354 H+ Antiporter protein; Region: 2A0121; TIGR00900 83332002355 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 83332002356 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332002357 PPE family; Region: PPE; pfam00823 83332002358 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332002359 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332002360 Protein of unknown function (DUF2530); Region: DUF2530; pfam10745 83332002361 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 83332002362 MarR family; Region: MarR; pfam01047 83332002363 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 83332002364 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 83332002365 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 83332002366 Protein of unknown function (DUF2537); Region: DUF2537; pfam10801 83332002367 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 83332002368 phosphoserine aminotransferase, putative; Region: serC_3; TIGR01366 83332002369 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 83332002370 catalytic residue [active] 83332002371 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 83332002372 Ferredoxin [Energy production and conversion]; Region: COG1146 83332002373 4Fe-4S binding domain; Region: Fer4; pfam00037 83332002374 ferredoxin-NADP+ reductase; Region: PLN02852 83332002375 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 83332002376 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 83332002377 putative dimer interface [polypeptide binding]; other site 83332002378 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 83332002379 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 83332002380 putative catalytic site [active] 83332002381 putative phosphate binding site [ion binding]; other site 83332002382 putative metal binding site [ion binding]; other site 83332002383 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 83332002384 dimer interface [polypeptide binding]; other site 83332002385 Citrate synthase; Region: Citrate_synt; pfam00285 83332002386 active site 83332002387 citrylCoA binding site [chemical binding]; other site 83332002388 oxalacetate/citrate binding site [chemical binding]; other site 83332002389 coenzyme A binding site [chemical binding]; other site 83332002390 catalytic triad [active] 83332002391 Predicted ATPase [General function prediction only]; Region: COG3903 83332002392 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 83332002393 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 83332002394 DNA binding residues [nucleotide binding] 83332002395 dimerization interface [polypeptide binding]; other site 83332002396 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 83332002397 cyclase homology domain; Region: CHD; cd07302 83332002398 nucleotidyl binding site; other site 83332002399 metal binding site [ion binding]; metal-binding site 83332002400 dimer interface [polypeptide binding]; other site 83332002401 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 83332002402 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 83332002403 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 83332002404 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 83332002405 AAA ATPase domain; Region: AAA_16; pfam13191 83332002406 Predicted ATPase [General function prediction only]; Region: COG3903 83332002407 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 83332002408 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 83332002409 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 83332002410 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 83332002411 dimer interface [polypeptide binding]; other site 83332002412 active site 83332002413 citrylCoA binding site [chemical binding]; other site 83332002414 NADH binding [chemical binding]; other site 83332002415 cationic pore residues; other site 83332002416 oxalacetate/citrate binding site [chemical binding]; other site 83332002417 coenzyme A binding site [chemical binding]; other site 83332002418 catalytic triad [active] 83332002419 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 83332002420 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 83332002421 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 83332002422 BON domain; Region: BON; pfam04972 83332002423 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 83332002424 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 83332002425 ligand binding site [chemical binding]; other site 83332002426 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 83332002427 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 83332002428 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 83332002429 dimerization interface [polypeptide binding]; other site 83332002430 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 83332002431 dimer interface [polypeptide binding]; other site 83332002432 phosphorylation site [posttranslational modification] 83332002433 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 83332002434 Mg2+ binding site [ion binding]; other site 83332002435 G-X-G motif; other site 83332002436 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 83332002437 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 83332002438 active site 83332002439 phosphorylation site [posttranslational modification] 83332002440 intermolecular recognition site; other site 83332002441 dimerization interface [polypeptide binding]; other site 83332002442 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 83332002443 DNA binding site [nucleotide binding] 83332002444 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 83332002445 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; COG0825 83332002446 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 83332002447 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 83332002448 substrate binding site [chemical binding]; other site 83332002449 oxyanion hole (OAH) forming residues; other site 83332002450 trimer interface [polypeptide binding]; other site 83332002451 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 83332002452 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 83332002453 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 83332002454 Beta-lactamase; Region: Beta-lactamase; pfam00144 83332002455 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 83332002456 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 83332002457 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 83332002458 Soluble P-type ATPase [General function prediction only]; Region: COG4087 83332002459 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 83332002460 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 83332002461 hydrophobic ligand binding site; other site 83332002462 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 83332002463 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 83332002464 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 83332002465 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 83332002466 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 83332002467 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 83332002468 acetyl-CoA acetyltransferase; Provisional; Region: PRK06289 83332002469 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 83332002470 active site 83332002471 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332002472 PPE family; Region: PPE; pfam00823 83332002473 PE family; Region: PE; pfam00934 83332002474 BCCT family transporter; Region: BCCT; pfam02028 83332002475 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 83332002476 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 83332002477 Coenzyme A binding pocket [chemical binding]; other site 83332002478 Transposase, Mutator family; Region: Transposase_mut; pfam00872 83332002479 MULE transposase domain; Region: MULE; pfam10551 83332002480 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 83332002481 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 83332002482 catalytic residues [active] 83332002483 catalytic nucleophile [active] 83332002484 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 83332002485 Probable transposase; Region: OrfB_IS605; pfam01385 83332002486 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 83332002487 putative active site pocket [active] 83332002488 dimerization interface [polypeptide binding]; other site 83332002489 putative catalytic residue [active] 83332002490 Phage-related replication protein [General function prediction only]; Region: COG4195 83332002491 manganese transport protein MntH; Reviewed; Region: PRK00701 83332002492 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 83332002493 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 83332002494 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 83332002495 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 83332002496 short chain dehydrogenase; Provisional; Region: PRK07814 83332002497 classical (c) SDRs; Region: SDR_c; cd05233 83332002498 NAD(P) binding site [chemical binding]; other site 83332002499 active site 83332002500 phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975 83332002501 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 83332002502 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 83332002503 dimer interface [polypeptide binding]; other site 83332002504 conserved gate region; other site 83332002505 putative PBP binding loops; other site 83332002506 ABC-ATPase subunit interface; other site 83332002507 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 83332002508 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 83332002509 dimer interface [polypeptide binding]; other site 83332002510 conserved gate region; other site 83332002511 putative PBP binding loops; other site 83332002512 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 83332002513 ABC-ATPase subunit interface; other site 83332002514 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 83332002515 Catalytic domain of Protein Kinases; Region: PKc; cd00180 83332002516 active site 83332002517 ATP binding site [chemical binding]; other site 83332002518 substrate binding site [chemical binding]; other site 83332002519 activation loop (A-loop); other site 83332002520 Uncharacterized conserved protein [Function unknown]; Region: COG3391 83332002521 NHL repeat; Region: NHL; pfam01436 83332002522 NHL repeat; Region: NHL; pfam01436 83332002523 NHL repeat; Region: NHL; pfam01436 83332002524 NHL repeat; Region: NHL; pfam01436 83332002525 NHL repeat; Region: NHL; pfam01436 83332002526 PBP superfamily domain; Region: PBP_like_2; cl17296 83332002527 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14271 83332002528 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 83332002529 Walker A/P-loop; other site 83332002530 ATP binding site [chemical binding]; other site 83332002531 Q-loop/lid; other site 83332002532 ABC transporter signature motif; other site 83332002533 Walker B; other site 83332002534 D-loop; other site 83332002535 H-loop/switch region; other site 83332002536 phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975 83332002537 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 83332002538 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 83332002539 dimer interface [polypeptide binding]; other site 83332002540 conserved gate region; other site 83332002541 putative PBP binding loops; other site 83332002542 ABC-ATPase subunit interface; other site 83332002543 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 83332002544 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 83332002545 dimer interface [polypeptide binding]; other site 83332002546 conserved gate region; other site 83332002547 putative PBP binding loops; other site 83332002548 ABC-ATPase subunit interface; other site 83332002549 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 83332002550 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 83332002551 putative DNA binding site [nucleotide binding]; other site 83332002552 putative homodimer interface [polypeptide binding]; other site 83332002553 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 83332002554 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 83332002555 nucleotide binding site [chemical binding]; other site 83332002556 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 83332002557 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 83332002558 active site 83332002559 DNA binding site [nucleotide binding] 83332002560 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 83332002561 DNA binding site [nucleotide binding] 83332002562 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 83332002563 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 83332002564 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 83332002565 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 83332002566 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 83332002567 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 83332002568 anti sigma factor interaction site; other site 83332002569 regulatory phosphorylation site [posttranslational modification]; other site 83332002570 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 83332002571 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 83332002572 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 83332002573 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 83332002574 short chain dehydrogenase; Provisional; Region: PRK08251 83332002575 classical (c) SDR, subgroup 6; Region: SDR_c6; cd05350 83332002576 putative NAD(P) binding site [chemical binding]; other site 83332002577 active site 83332002578 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 83332002579 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 83332002580 active site 83332002581 dimer interface [polypeptide binding]; other site 83332002582 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 83332002583 dimer interface [polypeptide binding]; other site 83332002584 active site 83332002585 hypothetical protein; Provisional; Region: PRK07857 83332002586 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 83332002587 Part of AAA domain; Region: AAA_19; pfam13245 83332002588 Family description; Region: UvrD_C_2; pfam13538 83332002589 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 83332002590 Peptidase family M23; Region: Peptidase_M23; pfam01551 83332002591 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 83332002592 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 83332002593 CoA-ligase; Region: Ligase_CoA; pfam00549 83332002594 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 83332002595 CoA binding domain; Region: CoA_binding; smart00881 83332002596 CoA-ligase; Region: Ligase_CoA; pfam00549 83332002597 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 83332002598 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 83332002599 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 83332002600 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 83332002601 active site 83332002602 substrate binding site [chemical binding]; other site 83332002603 cosubstrate binding site; other site 83332002604 catalytic site [active] 83332002605 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 83332002606 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 83332002607 purine monophosphate binding site [chemical binding]; other site 83332002608 dimer interface [polypeptide binding]; other site 83332002609 putative catalytic residues [active] 83332002610 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 83332002611 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 83332002612 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 83332002613 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 83332002614 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 83332002615 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 83332002616 metal ion-dependent adhesion site (MIDAS); other site 83332002617 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 83332002618 homotetrameric interface [polypeptide binding]; other site 83332002619 putative active site [active] 83332002620 metal binding site [ion binding]; metal-binding site 83332002621 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 83332002622 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 83332002623 Thermus thermophilus CsoR, a Cu(I)-sensing transcriptional regulator, and related domains; this domain family was previously known as part of DUF156; Region: TthCsoR-like_DUF156; cd10151 83332002624 putative homodimer interface [polypeptide binding]; other site 83332002625 putative homotetramer interface [polypeptide binding]; other site 83332002626 allosteric switch controlling residues; other site 83332002627 putative metal binding site [ion binding]; other site 83332002628 putative homodimer-homodimer interface [polypeptide binding]; other site 83332002629 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 83332002630 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 83332002631 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 83332002632 Soluble P-type ATPase [General function prediction only]; Region: COG4087 83332002633 enoyl-CoA hydratase; Provisional; Region: PRK07827 83332002634 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 83332002635 substrate binding site [chemical binding]; other site 83332002636 oxyanion hole (OAH) forming residues; other site 83332002637 trimer interface [polypeptide binding]; other site 83332002638 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332002639 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 83332002640 active site 83332002641 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 83332002642 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 83332002643 ATP-grasp domain; Region: ATP-grasp_4; cl17255 83332002644 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 83332002645 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 83332002646 carboxyltransferase (CT) interaction site; other site 83332002647 biotinylation site [posttranslational modification]; other site 83332002648 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 83332002649 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 83332002650 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332002651 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 83332002652 active site 83332002653 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 83332002654 PE family; Region: PE; pfam00934 83332002655 PE family; Region: PE; pfam00934 83332002656 Uncharacterized conserved protein [Function unknown]; Region: COG3391 83332002657 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 83332002658 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 83332002659 PE family; Region: PE; pfam00934 83332002660 Uncharacterized conserved protein [Function unknown]; Region: COG3391 83332002661 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 83332002662 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 83332002663 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 83332002664 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 83332002665 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 83332002666 active site 83332002667 phosphorylation site [posttranslational modification] 83332002668 intermolecular recognition site; other site 83332002669 dimerization interface [polypeptide binding]; other site 83332002670 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 83332002671 DNA binding site [nucleotide binding] 83332002672 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 83332002673 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 83332002674 dimerization interface [polypeptide binding]; other site 83332002675 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 83332002676 dimer interface [polypeptide binding]; other site 83332002677 phosphorylation site [posttranslational modification] 83332002678 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 83332002679 ATP binding site [chemical binding]; other site 83332002680 Mg2+ binding site [ion binding]; other site 83332002681 G-X-G motif; other site 83332002682 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 83332002683 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 83332002684 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 83332002685 MPT binding site; other site 83332002686 trimer interface [polypeptide binding]; other site 83332002687 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 83332002688 Large-conductance mechanosensitive channel, MscL; Region: MscL; pfam01741 83332002689 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 83332002690 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 83332002691 Walker A/P-loop; other site 83332002692 ATP binding site [chemical binding]; other site 83332002693 Q-loop/lid; other site 83332002694 ABC transporter signature motif; other site 83332002695 Walker B; other site 83332002696 D-loop; other site 83332002697 H-loop/switch region; other site 83332002698 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 83332002699 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 83332002700 FtsX-like permease family; Region: FtsX; pfam02687 83332002701 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 83332002702 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 83332002703 FtsX-like permease family; Region: FtsX; pfam02687 83332002704 Predicted secreted hydrolase [General function prediction only]; Region: COG5621 83332002705 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 83332002706 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 83332002707 substrate binding pocket [chemical binding]; other site 83332002708 chain length determination region; other site 83332002709 substrate-Mg2+ binding site; other site 83332002710 catalytic residues [active] 83332002711 aspartate-rich region 1; other site 83332002712 active site lid residues [active] 83332002713 aspartate-rich region 2; other site 83332002714 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 83332002715 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2331 83332002716 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 83332002717 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 83332002718 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 83332002719 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 83332002720 active site 83332002721 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 83332002722 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 83332002723 dimer interface [polypeptide binding]; other site 83332002724 putative functional site; other site 83332002725 putative MPT binding site; other site 83332002726 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 83332002727 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 83332002728 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 83332002729 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 83332002730 ligand binding site [chemical binding]; other site 83332002731 flexible hinge region; other site 83332002732 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 83332002733 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 83332002734 Coenzyme A binding pocket [chemical binding]; other site 83332002735 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 83332002736 arginine deiminase; Provisional; Region: PRK01388 83332002737 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 83332002738 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 83332002739 Predicted methyltransferases [General function prediction only]; Region: COG0313 83332002740 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 83332002741 putative SAM binding site [chemical binding]; other site 83332002742 putative homodimer interface [polypeptide binding]; other site 83332002743 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 83332002744 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 83332002745 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 83332002746 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 83332002747 active site 83332002748 HIGH motif; other site 83332002749 KMSKS motif; other site 83332002750 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 83332002751 tRNA binding surface [nucleotide binding]; other site 83332002752 anticodon binding site; other site 83332002753 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 83332002754 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 83332002755 active site 83332002756 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 83332002757 Domain of unknown function (DUF348); Region: DUF348; pfam03990 83332002758 Domain of unknown function (DUF348); Region: DUF348; pfam03990 83332002759 G5 domain; Region: G5; pfam07501 83332002760 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 83332002761 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 83332002762 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332002763 S-adenosylmethionine binding site [chemical binding]; other site 83332002764 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 83332002765 Increased loss of mitochondrial DNA protein 1; Region: Ilm1; pfam10311 83332002766 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 83332002767 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 83332002768 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 83332002769 acyl-activating enzyme (AAE) consensus motif; other site 83332002770 AMP binding site [chemical binding]; other site 83332002771 active site 83332002772 CoA binding site [chemical binding]; other site 83332002773 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 83332002774 putative active site [active] 83332002775 catalytic residue [active] 83332002776 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 83332002777 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 83332002778 5S rRNA interface [nucleotide binding]; other site 83332002779 CTC domain interface [polypeptide binding]; other site 83332002780 L16 interface [polypeptide binding]; other site 83332002781 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 83332002782 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 83332002783 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 83332002784 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 83332002785 active site 83332002786 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 83332002787 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 83332002788 Substrate binding site; other site 83332002789 Mg++ binding site; other site 83332002790 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 83332002791 active site 83332002792 substrate binding site [chemical binding]; other site 83332002793 CoA binding site [chemical binding]; other site 83332002794 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332002795 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332002796 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 83332002797 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 83332002798 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 83332002799 ATP binding site [chemical binding]; other site 83332002800 putative Mg++ binding site [ion binding]; other site 83332002801 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 83332002802 nucleotide binding region [chemical binding]; other site 83332002803 ATP-binding site [chemical binding]; other site 83332002804 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 83332002805 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 83332002806 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 83332002807 homodimer interface [polypeptide binding]; other site 83332002808 metal binding site [ion binding]; metal-binding site 83332002809 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 83332002810 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 83332002811 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 83332002812 N-acetyl-D-glucosamine binding site [chemical binding]; other site 83332002813 enolase; Provisional; Region: eno; PRK00077 83332002814 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 83332002815 dimer interface [polypeptide binding]; other site 83332002816 metal binding site [ion binding]; metal-binding site 83332002817 substrate binding pocket [chemical binding]; other site 83332002818 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 83332002819 Septum formation initiator; Region: DivIC; pfam04977 83332002820 Uncharacterized conserved protein [Function unknown]; Region: COG1507 83332002821 exopolyphosphatase; Region: exo_poly_only; TIGR03706 83332002822 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 83332002823 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 83332002824 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 83332002825 active site 83332002826 phosphorylation site [posttranslational modification] 83332002827 intermolecular recognition site; other site 83332002828 dimerization interface [polypeptide binding]; other site 83332002829 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 83332002830 DNA binding site [nucleotide binding] 83332002831 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 83332002832 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 83332002833 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 83332002834 Ligand Binding Site [chemical binding]; other site 83332002835 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 83332002836 dimer interface [polypeptide binding]; other site 83332002837 phosphorylation site [posttranslational modification] 83332002838 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 83332002839 ATP binding site [chemical binding]; other site 83332002840 Mg2+ binding site [ion binding]; other site 83332002841 G-X-G motif; other site 83332002842 K+-transporting ATPase, KdpA; Region: kdpA; TIGR00680 83332002843 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 83332002844 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 83332002845 Soluble P-type ATPase [General function prediction only]; Region: COG4087 83332002846 potassium-transporting ATPase subunit C; Provisional; Region: PRK14001 83332002847 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 83332002848 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 83332002849 dimer interface [polypeptide binding]; other site 83332002850 phosphorylation site [posttranslational modification] 83332002851 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 83332002852 ATP binding site [chemical binding]; other site 83332002853 Mg2+ binding site [ion binding]; other site 83332002854 G-X-G motif; other site 83332002855 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 83332002856 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 83332002857 active site 83332002858 phosphorylation site [posttranslational modification] 83332002859 intermolecular recognition site; other site 83332002860 dimerization interface [polypeptide binding]; other site 83332002861 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 83332002862 DNA binding site [nucleotide binding] 83332002863 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 83332002864 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 83332002865 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 83332002866 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 83332002867 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 83332002868 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332002869 PPE family; Region: PPE; pfam00823 83332002870 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 83332002871 PE family; Region: PE; pfam00934 83332002872 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 83332002873 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 83332002874 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 83332002875 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 83332002876 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 83332002877 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 83332002878 Predicted transcriptional regulator [Transcription]; Region: COG5340 83332002879 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 83332002880 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 83332002881 Transposase, Mutator family; Region: Transposase_mut; pfam00872 83332002882 MULE transposase domain; Region: MULE; pfam10551 83332002883 Transcriptional regulators [Transcription]; Region: MarR; COG1846 83332002884 MarR family; Region: MarR_2; pfam12802 83332002885 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 83332002886 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 83332002887 NAD(P) binding site [chemical binding]; other site 83332002888 active site 83332002889 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 83332002890 Helix-turn-helix domain; Region: HTH_17; pfam12728 83332002891 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 83332002892 Domain of unknown function (DUF427); Region: DUF427; cl00998 83332002893 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 83332002894 Uncharacterized conserved protein [Function unknown]; Region: COG3391 83332002895 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 83332002896 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 83332002897 dimer interface [polypeptide binding]; other site 83332002898 acyl-activating enzyme (AAE) consensus motif; other site 83332002899 putative active site [active] 83332002900 AMP binding site [chemical binding]; other site 83332002901 putative CoA binding site [chemical binding]; other site 83332002902 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 83332002903 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 83332002904 hydrophobic ligand binding site; other site 83332002905 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 83332002906 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 83332002907 putative active site [active] 83332002908 putative dimer interface [polypeptide binding]; other site 83332002909 Patatin-like phospholipase; Region: Patatin; pfam01734 83332002910 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 83332002911 nucleophile elbow; other site 83332002912 hypothetical protein; Provisional; Region: PRK10279 83332002913 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 83332002914 active site 83332002915 nucleophile elbow; other site 83332002916 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 83332002917 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 83332002918 active site residue [active] 83332002919 PE family; Region: PE; pfam00934 83332002920 PE family; Region: PE; pfam00934 83332002921 Predicted membrane protein [Function unknown]; Region: COG4425 83332002922 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 83332002923 enoyl-CoA hydratase; Provisional; Region: PRK05862 83332002924 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 83332002925 substrate binding site [chemical binding]; other site 83332002926 oxyanion hole (OAH) forming residues; other site 83332002927 trimer interface [polypeptide binding]; other site 83332002928 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 83332002929 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 83332002930 substrate binding site [chemical binding]; other site 83332002931 oxyanion hole (OAH) forming residues; other site 83332002932 trimer interface [polypeptide binding]; other site 83332002933 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 83332002934 Predicted membrane protein [Function unknown]; Region: COG4760 83332002935 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 83332002936 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 83332002937 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 83332002938 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 83332002939 dimer interface [polypeptide binding]; other site 83332002940 active site 83332002941 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 83332002942 active site 83332002943 catalytic triad [active] 83332002944 oxyanion hole [active] 83332002945 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 83332002946 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 83332002947 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 83332002948 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 83332002949 dimer interface [polypeptide binding]; other site 83332002950 pyridoxal 5'-phosphate binding site [chemical binding]; other site 83332002951 catalytic residue [active] 83332002952 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 83332002953 RDD family; Region: RDD; pfam06271 83332002954 cystathionine gamma-synthase; Provisional; Region: PRK07811 83332002955 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 83332002956 homodimer interface [polypeptide binding]; other site 83332002957 substrate-cofactor binding pocket; other site 83332002958 pyridoxal 5'-phosphate binding site [chemical binding]; other site 83332002959 catalytic residue [active] 83332002960 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 83332002961 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 83332002962 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 83332002963 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 83332002964 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 83332002965 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 83332002966 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 83332002967 catalytic residues [active] 83332002968 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 83332002969 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 83332002970 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 83332002971 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 83332002972 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 83332002973 catalytic residue [active] 83332002974 putative FPP diphosphate binding site; other site 83332002975 putative FPP binding hydrophobic cleft; other site 83332002976 dimer interface [polypeptide binding]; other site 83332002977 putative IPP diphosphate binding site; other site 83332002978 PE family; Region: PE; pfam00934 83332002979 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 83332002980 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 83332002981 putative IPP diphosphate binding site; other site 83332002982 PE family; Region: PE; pfam00934 83332002983 Glycosyl hydrolase family 12; Region: Glyco_hydro_12; pfam01670 83332002984 PE family; Region: PE; pfam00934 83332002985 pantothenate kinase; Provisional; Region: PRK05439 83332002986 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 83332002987 ATP-binding site [chemical binding]; other site 83332002988 CoA-binding site [chemical binding]; other site 83332002989 Mg2+-binding site [ion binding]; other site 83332002990 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 83332002991 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 83332002992 dimer interface [polypeptide binding]; other site 83332002993 active site 83332002994 glycine-pyridoxal phosphate binding site [chemical binding]; other site 83332002995 folate binding site [chemical binding]; other site 83332002996 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 83332002997 dinuclear metal binding motif [ion binding]; other site 83332002998 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 83332002999 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 83332003000 putative active site [active] 83332003001 PhoH-like protein; Region: PhoH; pfam02562 83332003002 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 83332003003 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 83332003004 NodB motif; other site 83332003005 active site 83332003006 catalytic site [active] 83332003007 metal binding site [ion binding]; metal-binding site 83332003008 fumarate hydratase; Reviewed; Region: fumC; PRK00485 83332003009 Class II fumarases; Region: Fumarase_classII; cd01362 83332003010 active site 83332003011 tetramer interface [polypeptide binding]; other site 83332003012 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 83332003013 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 83332003014 putative active site [active] 83332003015 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 83332003016 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 83332003017 Domain of unknown function DUF20; Region: UPF0118; pfam01594 83332003018 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 83332003019 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 83332003020 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 83332003021 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 83332003022 3beta-hydroxysteroid dehydrogenases (3b-HSD)-like, extended (e) SDRs; Region: 3b-HSD-like_SDR_e; cd05241 83332003023 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 83332003024 putative NAD(P) binding site [chemical binding]; other site 83332003025 active site 83332003026 putative substrate binding site [chemical binding]; other site 83332003027 exodeoxyribonuclease VII, small subunit; Region: xseB; TIGR01280 83332003028 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 83332003029 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 83332003030 generic binding surface II; other site 83332003031 generic binding surface I; other site 83332003032 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 83332003033 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 83332003034 Yip1 domain; Region: Yip1; pfam04893 83332003035 GTP-binding protein YchF; Reviewed; Region: PRK09601 83332003036 YchF GTPase; Region: YchF; cd01900 83332003037 G1 box; other site 83332003038 GTP/Mg2+ binding site [chemical binding]; other site 83332003039 Switch I region; other site 83332003040 G2 box; other site 83332003041 Switch II region; other site 83332003042 G3 box; other site 83332003043 G4 box; other site 83332003044 G5 box; other site 83332003045 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 83332003046 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 83332003047 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487 83332003048 putative active site [active] 83332003049 Uncharacterized conserved protein [Function unknown]; Region: COG1359 83332003050 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 83332003051 cyclase homology domain; Region: CHD; cd07302 83332003052 nucleotidyl binding site; other site 83332003053 metal binding site [ion binding]; metal-binding site 83332003054 dimer interface [polypeptide binding]; other site 83332003055 glucose-6-phosphate 1-dehydrogenase; Region: zwf; TIGR00871 83332003056 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 83332003057 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 83332003058 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 83332003059 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd_rel; TIGR00872 83332003060 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 83332003061 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 83332003062 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 83332003063 pyruvate phosphate dikinase; Provisional; Region: PRK05878 83332003064 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 83332003065 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 83332003066 Domain of unknown function (DUF222); Region: DUF222; pfam02720 83332003067 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 83332003068 active site 83332003069 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 83332003070 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 83332003071 non-specific DNA binding site [nucleotide binding]; other site 83332003072 salt bridge; other site 83332003073 sequence-specific DNA binding site [nucleotide binding]; other site 83332003074 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 83332003075 Domain of unknown function (DUF955); Region: DUF955; pfam06114 83332003076 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 83332003077 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 83332003078 citrate synthase; Provisional; Region: PRK14033 83332003079 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 83332003080 oxalacetate binding site [chemical binding]; other site 83332003081 citrylCoA binding site [chemical binding]; other site 83332003082 coenzyme A binding site [chemical binding]; other site 83332003083 catalytic triad [active] 83332003084 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 83332003085 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 83332003086 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 83332003087 THF binding site; other site 83332003088 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 83332003089 substrate binding site [chemical binding]; other site 83332003090 THF binding site; other site 83332003091 zinc-binding site [ion binding]; other site 83332003092 PPE family; Region: PPE; pfam00823 83332003093 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 83332003094 active site 83332003095 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 83332003096 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 83332003097 substrate binding site [chemical binding]; other site 83332003098 oxyanion hole (OAH) forming residues; other site 83332003099 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 83332003100 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 83332003101 CAAX protease self-immunity; Region: Abi; pfam02517 83332003102 enoyl-CoA hydratase; Provisional; Region: PRK06688 83332003103 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 83332003104 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 83332003105 trimer interface [polypeptide binding]; other site 83332003106 enoyl-CoA hydratase; Provisional; Region: PRK06688 83332003107 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 83332003108 substrate binding site [chemical binding]; other site 83332003109 oxyanion hole (OAH) forming residues; other site 83332003110 trimer interface [polypeptide binding]; other site 83332003111 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 83332003112 CoA-transferase family III; Region: CoA_transf_3; pfam02515 83332003113 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 83332003114 NAD binding site [chemical binding]; other site 83332003115 homodimer interface [polypeptide binding]; other site 83332003116 homotetramer interface [polypeptide binding]; other site 83332003117 active site 83332003118 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 83332003119 MMPL family; Region: MMPL; pfam03176 83332003120 Domain of unknown function (DUF222); Region: DUF222; pfam02720 83332003121 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 83332003122 active site 83332003123 NAD-dependent deacetylase; Provisional; Region: PRK00481 83332003124 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 83332003125 NAD+ binding site [chemical binding]; other site 83332003126 substrate binding site [chemical binding]; other site 83332003127 Zn binding site [ion binding]; other site 83332003128 Predicted transcriptional regulators [Transcription]; Region: COG1725 83332003129 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 83332003130 DNA-binding site [nucleotide binding]; DNA binding site 83332003131 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 83332003132 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 83332003133 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 83332003134 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 83332003135 uncharacterized HhH-GPD family protein; Region: TIGR03252 83332003136 minor groove reading motif; other site 83332003137 helix-hairpin-helix signature motif; other site 83332003138 mannosyltransferase; Provisional; Region: pimE; PRK13375 83332003139 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 83332003140 aromatic arch; other site 83332003141 DCoH dimer interaction site [polypeptide binding]; other site 83332003142 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 83332003143 DCoH tetramer interaction site [polypeptide binding]; other site 83332003144 substrate binding site [chemical binding]; other site 83332003145 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 83332003146 active site 83332003147 8-oxo-dGMP binding site [chemical binding]; other site 83332003148 nudix motif; other site 83332003149 metal binding site [ion binding]; metal-binding site 83332003150 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 83332003151 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 83332003152 [4Fe-4S] binding site [ion binding]; other site 83332003153 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 83332003154 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 83332003155 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 83332003156 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 83332003157 molybdopterin cofactor binding site; other site 83332003158 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 83332003159 nitrate reductase molybdenum cofactor assembly chaperone; Region: narJ; TIGR00684 83332003160 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 83332003161 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 83332003162 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 83332003163 G1 box; other site 83332003164 putative GEF interaction site [polypeptide binding]; other site 83332003165 GTP/Mg2+ binding site [chemical binding]; other site 83332003166 Switch I region; other site 83332003167 G2 box; other site 83332003168 G3 box; other site 83332003169 Switch II region; other site 83332003170 G4 box; other site 83332003171 G5 box; other site 83332003172 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 83332003173 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 83332003174 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 83332003175 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 83332003176 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 83332003177 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332003178 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332003179 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332003180 PPE family; Region: PPE; pfam00823 83332003181 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 83332003182 PE family; Region: PE; pfam00934 83332003183 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 83332003184 PE family; Region: PE; pfam00934 83332003185 FO synthase; Reviewed; Region: fbiC; PRK09234 83332003186 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 83332003187 FeS/SAM binding site; other site 83332003188 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 83332003189 FeS/SAM binding site; other site 83332003190 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 83332003191 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 83332003192 active site 83332003193 FMN binding site [chemical binding]; other site 83332003194 2,4-decadienoyl-CoA binding site; other site 83332003195 catalytic residue [active] 83332003196 4Fe-4S cluster binding site [ion binding]; other site 83332003197 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 83332003198 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 83332003199 Predicted transcriptional regulators [Transcription]; Region: COG1695 83332003200 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 83332003201 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 83332003202 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 83332003203 4Fe-4S binding domain; Region: Fer4; pfam00037 83332003204 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 83332003205 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 83332003206 pyridoxal 5'-phosphate binding site [chemical binding]; other site 83332003207 homodimer interface [polypeptide binding]; other site 83332003208 catalytic residue [active] 83332003209 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 83332003210 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 83332003211 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 83332003212 ATP binding site [chemical binding]; other site 83332003213 putative Mg++ binding site [ion binding]; other site 83332003214 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 83332003215 ATP-binding site [chemical binding]; other site 83332003216 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 83332003217 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 83332003218 active site 83332003219 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 83332003220 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 83332003221 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 83332003222 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 83332003223 Enoylreductase; Region: PKS_ER; smart00829 83332003224 NAD(P) binding site [chemical binding]; other site 83332003225 KR domain; Region: KR; pfam08659 83332003226 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 83332003227 putative NADP binding site [chemical binding]; other site 83332003228 active site 83332003229 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 83332003230 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 83332003231 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 83332003232 PE-PPE domain; Region: PE-PPE; pfam08237 83332003233 acyl-CoA synthetase; Validated; Region: PRK05850 83332003234 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 83332003235 acyl-activating enzyme (AAE) consensus motif; other site 83332003236 active site 83332003237 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 83332003238 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 83332003239 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 83332003240 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 83332003241 Glutamate binding site [chemical binding]; other site 83332003242 NAD binding site [chemical binding]; other site 83332003243 catalytic residues [active] 83332003244 Proline dehydrogenase; Region: Pro_dh; pfam01619 83332003245 RNA polymerase sigma factor SigI; Provisional; Region: sigI; PRK09635 83332003246 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 83332003247 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 83332003248 DNA binding residues [nucleotide binding] 83332003249 haloalkane dehalogenase; Provisional; Region: PRK03204 83332003250 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 83332003251 catalytic site [active] 83332003252 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 83332003253 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 83332003254 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 83332003255 PGAP1-like protein; Region: PGAP1; pfam07819 83332003256 acyl-CoA synthetase; Validated; Region: PRK07787 83332003257 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 83332003258 acyl-activating enzyme (AAE) consensus motif; other site 83332003259 AMP binding site [chemical binding]; other site 83332003260 active site 83332003261 CoA binding site [chemical binding]; other site 83332003262 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 83332003263 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 83332003264 PE family; Region: PE; pfam00934 83332003265 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332003266 PPE family; Region: PPE; pfam00823 83332003267 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 83332003268 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 83332003269 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 83332003270 Transposase, Mutator family; Region: Transposase_mut; pfam00872 83332003271 MULE transposase domain; Region: MULE; pfam10551 83332003272 metabolite-proton symporter; Region: 2A0106; TIGR00883 83332003273 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 83332003274 putative substrate translocation pore; other site 83332003275 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 83332003276 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 83332003277 putative trimer interface [polypeptide binding]; other site 83332003278 putative CoA binding site [chemical binding]; other site 83332003279 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 83332003280 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 83332003281 metal binding site [ion binding]; metal-binding site 83332003282 putative dimer interface [polypeptide binding]; other site 83332003283 TIGR00730 family protein; Region: TIGR00730 83332003284 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 83332003285 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 83332003286 acyl-activating enzyme (AAE) consensus motif; other site 83332003287 putative AMP binding site [chemical binding]; other site 83332003288 putative active site [active] 83332003289 putative CoA binding site [chemical binding]; other site 83332003290 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 83332003291 dihydropteroate synthase; Region: DHPS; TIGR01496 83332003292 substrate binding pocket [chemical binding]; other site 83332003293 dimer interface [polypeptide binding]; other site 83332003294 inhibitor binding site; inhibition site 83332003295 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 83332003296 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 83332003297 DivIVA domain; Region: DivI1A_domain; TIGR03544 83332003298 DNA-3-methyladenine glycosylase I; Region: tag; TIGR00624 83332003299 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 83332003300 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 83332003301 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 83332003302 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 83332003303 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 83332003304 ligand binding site; other site 83332003305 oligomer interface; other site 83332003306 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 83332003307 dimer interface [polypeptide binding]; other site 83332003308 N-terminal domain interface [polypeptide binding]; other site 83332003309 sulfate 1 binding site; other site 83332003310 PE family; Region: PE; pfam00934 83332003311 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 83332003312 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 83332003313 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 83332003314 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 83332003315 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 83332003316 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 83332003317 Walker A/P-loop; other site 83332003318 ATP binding site [chemical binding]; other site 83332003319 Q-loop/lid; other site 83332003320 ABC transporter signature motif; other site 83332003321 Walker B; other site 83332003322 D-loop; other site 83332003323 H-loop/switch region; other site 83332003324 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 83332003325 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332003326 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 83332003327 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332003328 S-adenosylmethionine binding site [chemical binding]; other site 83332003329 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 83332003330 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 83332003331 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 83332003332 DNA binding residues [nucleotide binding] 83332003333 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 83332003334 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 83332003335 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 83332003336 protein binding site [polypeptide binding]; other site 83332003337 sec-independent translocase; Provisional; Region: PRK03100 83332003338 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 83332003339 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 83332003340 active site 83332003341 motif I; other site 83332003342 motif II; other site 83332003343 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 83332003344 Predicted membrane protein [Function unknown]; Region: COG3428 83332003345 Bacterial PH domain; Region: DUF304; pfam03703 83332003346 Uncharacterized conserved protein [Function unknown]; Region: COG3402 83332003347 Domain of unknown function DUF59; Region: DUF59; cl00941 83332003348 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 83332003349 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 83332003350 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 83332003351 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 83332003352 N-acetyl-D-glucosamine binding site [chemical binding]; other site 83332003353 catalytic residue [active] 83332003354 Predicted membrane protein [Function unknown]; Region: COG4420 83332003355 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 83332003356 MgtE intracellular N domain; Region: MgtE_N; smart00924 83332003357 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 83332003358 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 83332003359 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 83332003360 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 83332003361 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 83332003362 dimer interface [polypeptide binding]; other site 83332003363 conserved gate region; other site 83332003364 putative PBP binding loops; other site 83332003365 ABC-ATPase subunit interface; other site 83332003366 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 83332003367 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 83332003368 dimer interface [polypeptide binding]; other site 83332003369 conserved gate region; other site 83332003370 ABC-ATPase subunit interface; other site 83332003371 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 83332003372 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 83332003373 Walker A/P-loop; other site 83332003374 ATP binding site [chemical binding]; other site 83332003375 Q-loop/lid; other site 83332003376 ABC transporter signature motif; other site 83332003377 Walker B; other site 83332003378 D-loop; other site 83332003379 H-loop/switch region; other site 83332003380 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 83332003381 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 83332003382 oligomer interface [polypeptide binding]; other site 83332003383 metal binding site [ion binding]; metal-binding site 83332003384 metal binding site [ion binding]; metal-binding site 83332003385 putative Cl binding site [ion binding]; other site 83332003386 basic sphincter; other site 83332003387 hydrophobic gate; other site 83332003388 periplasmic entrance; other site 83332003389 malate dehydrogenase; Provisional; Region: PRK05442 83332003390 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 83332003391 NAD(P) binding site [chemical binding]; other site 83332003392 dimer interface [polypeptide binding]; other site 83332003393 malate binding site [chemical binding]; other site 83332003394 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 83332003395 PE family; Region: PE; pfam00934 83332003396 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 83332003397 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 83332003398 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 83332003399 NAD(P) binding site [chemical binding]; other site 83332003400 active site 83332003401 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 83332003402 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 83332003403 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 83332003404 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 83332003405 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 83332003406 TPP-binding site [chemical binding]; other site 83332003407 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 83332003408 dimer interface [polypeptide binding]; other site 83332003409 PYR/PP interface [polypeptide binding]; other site 83332003410 TPP binding site [chemical binding]; other site 83332003411 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 83332003412 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 83332003413 putative substrate translocation pore; other site 83332003414 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 83332003415 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 83332003416 RNase_H superfamily; Region: RNase_H_2; pfam13482 83332003417 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 83332003418 Part of AAA domain; Region: AAA_19; pfam13245 83332003419 AAA domain; Region: AAA_12; pfam13087 83332003420 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 83332003421 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 83332003422 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 83332003423 ATP binding site [chemical binding]; other site 83332003424 Mg++ binding site [ion binding]; other site 83332003425 motif III; other site 83332003426 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 83332003427 nucleotide binding region [chemical binding]; other site 83332003428 ATP-binding site [chemical binding]; other site 83332003429 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 83332003430 putative RNA binding site [nucleotide binding]; other site 83332003431 Acyltransferase family; Region: Acyl_transf_3; pfam01757 83332003432 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332003433 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332003434 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 83332003435 FAD binding domain; Region: FAD_binding_4; pfam01565 83332003436 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 83332003437 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 83332003438 H+ Antiporter protein; Region: 2A0121; TIGR00900 83332003439 putative substrate translocation pore; other site 83332003440 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 83332003441 Fe-S cluster binding site [ion binding]; other site 83332003442 DNA binding site [nucleotide binding] 83332003443 active site 83332003444 hypothetical protein; Validated; Region: PRK05868 83332003445 hypothetical protein; Provisional; Region: PRK07236 83332003446 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 83332003447 Domain of unknown function (DUF385); Region: DUF385; pfam04075 83332003448 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 83332003449 HIT family signature motif; other site 83332003450 catalytic residue [active] 83332003451 amidase; Provisional; Region: PRK12470 83332003452 Amidase; Region: Amidase; pfam01425 83332003453 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 83332003454 cyclase homology domain; Region: CHD; cd07302 83332003455 nucleotidyl binding site; other site 83332003456 metal binding site [ion binding]; metal-binding site 83332003457 dimer interface [polypeptide binding]; other site 83332003458 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 83332003459 Catalytic domain of Protein Kinases; Region: PKc; cd00180 83332003460 active site 83332003461 ATP binding site [chemical binding]; other site 83332003462 substrate binding site [chemical binding]; other site 83332003463 activation loop (A-loop); other site 83332003464 PknH-like extracellular domain; Region: PknH_C; pfam14032 83332003465 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 83332003466 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 83332003467 DNA binding site [nucleotide binding] 83332003468 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 83332003469 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 83332003470 phosphopeptide binding site; other site 83332003471 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 83332003472 putative active site [active] 83332003473 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 83332003474 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 83332003475 Protein of unknown function (DUF732); Region: DUF732; pfam05305 83332003476 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 83332003477 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 83332003478 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 83332003479 Walker A/P-loop; other site 83332003480 ATP binding site [chemical binding]; other site 83332003481 Q-loop/lid; other site 83332003482 ABC transporter signature motif; other site 83332003483 Walker B; other site 83332003484 D-loop; other site 83332003485 H-loop/switch region; other site 83332003486 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 83332003487 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 83332003488 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 83332003489 Walker A/P-loop; other site 83332003490 ATP binding site [chemical binding]; other site 83332003491 Q-loop/lid; other site 83332003492 ABC transporter signature motif; other site 83332003493 Walker B; other site 83332003494 D-loop; other site 83332003495 H-loop/switch region; other site 83332003496 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 83332003497 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 83332003498 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 83332003499 catalytic core [active] 83332003500 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 83332003501 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 83332003502 active site 83332003503 metal binding site [ion binding]; metal-binding site 83332003504 DNA binding site [nucleotide binding] 83332003505 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 83332003506 Walker A/P-loop; other site 83332003507 ATP binding site [chemical binding]; other site 83332003508 choline dehydrogenase; Validated; Region: PRK02106 83332003509 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 83332003510 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 83332003511 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 83332003512 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 83332003513 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 83332003514 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 83332003515 Walker A/P-loop; other site 83332003516 ATP binding site [chemical binding]; other site 83332003517 Q-loop/lid; other site 83332003518 ABC transporter signature motif; other site 83332003519 Walker B; other site 83332003520 D-loop; other site 83332003521 H-loop/switch region; other site 83332003522 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 83332003523 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 83332003524 Walker A/P-loop; other site 83332003525 ATP binding site [chemical binding]; other site 83332003526 Q-loop/lid; other site 83332003527 ABC transporter signature motif; other site 83332003528 Walker B; other site 83332003529 D-loop; other site 83332003530 H-loop/switch region; other site 83332003531 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 83332003532 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 83332003533 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 83332003534 dimer interface [polypeptide binding]; other site 83332003535 conserved gate region; other site 83332003536 putative PBP binding loops; other site 83332003537 ABC-ATPase subunit interface; other site 83332003538 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 83332003539 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 83332003540 dimer interface [polypeptide binding]; other site 83332003541 conserved gate region; other site 83332003542 putative PBP binding loops; other site 83332003543 ABC-ATPase subunit interface; other site 83332003544 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 83332003545 active site clefts [active] 83332003546 zinc binding site [ion binding]; other site 83332003547 dimer interface [polypeptide binding]; other site 83332003548 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 83332003549 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 83332003550 Active Sites [active] 83332003551 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 83332003552 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 83332003553 CysD dimerization site [polypeptide binding]; other site 83332003554 G1 box; other site 83332003555 putative GEF interaction site [polypeptide binding]; other site 83332003556 GTP/Mg2+ binding site [chemical binding]; other site 83332003557 Switch I region; other site 83332003558 G2 box; other site 83332003559 G3 box; other site 83332003560 Switch II region; other site 83332003561 G4 box; other site 83332003562 G5 box; other site 83332003563 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 83332003564 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 83332003565 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 83332003566 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 83332003567 Walker A/P-loop; other site 83332003568 ligand-binding site [chemical binding]; other site 83332003569 ATP binding site [chemical binding]; other site 83332003570 Rrf2 family protein; Region: rrf2_super; TIGR00738 83332003571 Transcriptional regulator; Region: Rrf2; pfam02082 83332003572 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 83332003573 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 83332003574 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 83332003575 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 83332003576 Putative esterase; Region: Esterase; pfam00756 83332003577 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 83332003578 Predicted membrane protein [Function unknown]; Region: COG4325 83332003579 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 83332003580 Protein of unknown function (DUF732); Region: DUF732; pfam05305 83332003581 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 83332003582 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 83332003583 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 83332003584 active site 83332003585 HIGH motif; other site 83332003586 KMSK motif region; other site 83332003587 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 83332003588 tRNA binding surface [nucleotide binding]; other site 83332003589 anticodon binding site; other site 83332003590 diaminopimelate decarboxylase; Region: lysA; TIGR01048 83332003591 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 83332003592 active site 83332003593 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 83332003594 substrate binding site [chemical binding]; other site 83332003595 catalytic residues [active] 83332003596 dimer interface [polypeptide binding]; other site 83332003597 homoserine dehydrogenase; Provisional; Region: PRK06349 83332003598 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 83332003599 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 83332003600 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 83332003601 threonine synthase; Reviewed; Region: PRK06721 83332003602 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 83332003603 homodimer interface [polypeptide binding]; other site 83332003604 pyridoxal 5'-phosphate binding site [chemical binding]; other site 83332003605 catalytic residue [active] 83332003606 Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083 83332003607 transcription termination factor Rho; Provisional; Region: PRK12678 83332003608 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 83332003609 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 83332003610 RNA binding site [nucleotide binding]; other site 83332003611 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 83332003612 multimer interface [polypeptide binding]; other site 83332003613 Walker A motif; other site 83332003614 ATP binding site [chemical binding]; other site 83332003615 Walker B motif; other site 83332003616 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 83332003617 peptide chain release factor 1; Region: prfA; TIGR00019 83332003618 This domain is found in peptide chain release factors; Region: PCRF; smart00937 83332003619 RF-1 domain; Region: RF-1; pfam00472 83332003620 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 83332003621 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332003622 S-adenosylmethionine binding site [chemical binding]; other site 83332003623 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 83332003624 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 83332003625 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 83332003626 Mg++ binding site [ion binding]; other site 83332003627 putative catalytic motif [active] 83332003628 substrate binding site [chemical binding]; other site 83332003629 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 83332003630 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 83332003631 F0F1 ATP synthase subunit C; Validated; Region: PRK05880 83332003632 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 83332003633 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 83332003634 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13428 83332003635 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 83332003636 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 83332003637 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 83332003638 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 83332003639 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 83332003640 Walker A motif; other site 83332003641 ATP binding site [chemical binding]; other site 83332003642 Walker B motif; other site 83332003643 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 83332003644 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 83332003645 core domain interface [polypeptide binding]; other site 83332003646 delta subunit interface [polypeptide binding]; other site 83332003647 epsilon subunit interface [polypeptide binding]; other site 83332003648 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 83332003649 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 83332003650 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 83332003651 alpha subunit interaction interface [polypeptide binding]; other site 83332003652 Walker A motif; other site 83332003653 ATP binding site [chemical binding]; other site 83332003654 Walker B motif; other site 83332003655 inhibitor binding site; inhibition site 83332003656 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 83332003657 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 83332003658 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 83332003659 gamma subunit interface [polypeptide binding]; other site 83332003660 epsilon subunit interface [polypeptide binding]; other site 83332003661 LBP interface [polypeptide binding]; other site 83332003662 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 83332003663 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 83332003664 Transposase; Region: DDE_Tnp_ISL3; pfam01610 83332003665 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 83332003666 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 83332003667 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 83332003668 hinge; other site 83332003669 active site 83332003670 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 83332003671 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 83332003672 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 83332003673 DNA binding site [nucleotide binding] 83332003674 active site 83332003675 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 83332003676 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 83332003677 AlkA N-terminal domain; Region: AlkA_N; pfam06029 83332003678 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 83332003679 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 83332003680 minor groove reading motif; other site 83332003681 helix-hairpin-helix signature motif; other site 83332003682 substrate binding pocket [chemical binding]; other site 83332003683 active site 83332003684 HAMP domain; Region: HAMP; pfam00672 83332003685 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 83332003686 cyclase homology domain; Region: CHD; cd07302 83332003687 nucleotidyl binding site; other site 83332003688 metal binding site [ion binding]; metal-binding site 83332003689 dimer interface [polypeptide binding]; other site 83332003690 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 83332003691 dimerization interface [polypeptide binding]; other site 83332003692 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 83332003693 cyclase homology domain; Region: CHD; cd07302 83332003694 nucleotidyl binding site; other site 83332003695 metal binding site [ion binding]; metal-binding site 83332003696 dimer interface [polypeptide binding]; other site 83332003697 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 83332003698 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 83332003699 dimerization interface [polypeptide binding]; other site 83332003700 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 83332003701 cyclase homology domain; Region: CHD; cd07302 83332003702 nucleotidyl binding site; other site 83332003703 metal binding site [ion binding]; metal-binding site 83332003704 dimer interface [polypeptide binding]; other site 83332003705 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 83332003706 hypothetical protein; Provisional; Region: PRK03298 83332003707 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 83332003708 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 83332003709 dimer interface [polypeptide binding]; other site 83332003710 substrate binding site [chemical binding]; other site 83332003711 metal binding site [ion binding]; metal-binding site 83332003712 putative acyltransferase; Provisional; Region: PRK05790 83332003713 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 83332003714 dimer interface [polypeptide binding]; other site 83332003715 active site 83332003716 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 83332003717 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 83332003718 PE family; Region: PE; pfam00934 83332003719 glycogen branching enzyme; Provisional; Region: PRK05402 83332003720 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 83332003721 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 83332003722 active site 83332003723 catalytic site [active] 83332003724 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 83332003725 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 83332003726 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 83332003727 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 83332003728 active site 83332003729 homodimer interface [polypeptide binding]; other site 83332003730 catalytic site [active] 83332003731 acceptor binding site [chemical binding]; other site 83332003732 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 83332003733 putative homodimer interface [polypeptide binding]; other site 83332003734 putative active site pocket [active] 83332003735 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 83332003736 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 83332003737 DEAD/DEAH box helicase; Region: DEAD; pfam00270 83332003738 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 83332003739 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 83332003740 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 83332003741 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 83332003742 active site 83332003743 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 83332003744 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 83332003745 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 83332003746 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 83332003747 putative active site pocket [active] 83332003748 cleavage site 83332003749 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 83332003750 MPN+ (JAMM) motif; other site 83332003751 Zinc-binding site [ion binding]; other site 83332003752 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 83332003753 MoaE interaction surface [polypeptide binding]; other site 83332003754 MoeB interaction surface [polypeptide binding]; other site 83332003755 thiocarboxylated glycine; other site 83332003756 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 83332003757 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 83332003758 dimer interface [polypeptide binding]; other site 83332003759 pyridoxal 5'-phosphate binding site [chemical binding]; other site 83332003760 catalytic residue [active] 83332003761 Rhomboid family; Region: Rhomboid; pfam01694 83332003762 glutamate racemase; Provisional; Region: PRK00865 83332003763 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 83332003764 ribonuclease PH; Reviewed; Region: rph; PRK00173 83332003765 Ribonuclease PH; Region: RNase_PH_bact; cd11362 83332003766 hexamer interface [polypeptide binding]; other site 83332003767 active site 83332003768 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 83332003769 active site 83332003770 dimerization interface [polypeptide binding]; other site 83332003771 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 83332003772 Glucitol operon activator [Transcription]; Region: GutM; COG4578 83332003773 acyl carrier protein; Validated; Region: PRK05883 83332003774 long-chain-fatty-acid--[acyl-carrier-protein] ligase; Validated; Region: PRK05851 83332003775 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 83332003776 acyl-activating enzyme (AAE) consensus motif; other site 83332003777 active site 83332003778 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332003779 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 83332003780 active site 83332003781 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 83332003782 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 83332003783 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 83332003784 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 83332003785 FAD binding pocket [chemical binding]; other site 83332003786 FAD binding motif [chemical binding]; other site 83332003787 phosphate binding motif [ion binding]; other site 83332003788 NAD binding pocket [chemical binding]; other site 83332003789 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 83332003790 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 83332003791 Walker A/P-loop; other site 83332003792 ATP binding site [chemical binding]; other site 83332003793 Q-loop/lid; other site 83332003794 ABC transporter signature motif; other site 83332003795 Walker B; other site 83332003796 D-loop; other site 83332003797 H-loop/switch region; other site 83332003798 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 83332003799 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 83332003800 Walker A/P-loop; other site 83332003801 ATP binding site [chemical binding]; other site 83332003802 Q-loop/lid; other site 83332003803 ABC transporter signature motif; other site 83332003804 Walker B; other site 83332003805 D-loop; other site 83332003806 H-loop/switch region; other site 83332003807 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 83332003808 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 83332003809 NAD(P) binding site [chemical binding]; other site 83332003810 active site 83332003811 tetracycline repressor protein TetR; Provisional; Region: PRK13756 83332003812 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332003813 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 83332003814 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 83332003815 GAF domain; Region: GAF; pfam01590 83332003816 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 83332003817 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 83332003818 metal binding site [ion binding]; metal-binding site 83332003819 active site 83332003820 I-site; other site 83332003821 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 83332003822 hypothetical protein; Provisional; Region: PRK07877 83332003823 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 83332003824 ATP binding site [chemical binding]; other site 83332003825 substrate interface [chemical binding]; other site 83332003826 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 83332003827 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 83332003828 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 83332003829 cyclase homology domain; Region: CHD; cd07302 83332003830 nucleotidyl binding site; other site 83332003831 dimer interface [polypeptide binding]; other site 83332003832 metal binding site [ion binding]; metal-binding site 83332003833 AAA ATPase domain; Region: AAA_16; pfam13191 83332003834 Predicted ATPase [General function prediction only]; Region: COG3903 83332003835 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 83332003836 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 83332003837 DNA binding residues [nucleotide binding] 83332003838 dimerization interface [polypeptide binding]; other site 83332003839 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 83332003840 cyclase homology domain; Region: CHD; cd07302 83332003841 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 83332003842 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 83332003843 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332003844 PPE family; Region: PPE; pfam00823 83332003845 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 83332003846 PAS fold; Region: PAS_4; pfam08448 83332003847 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 83332003848 putative active site [active] 83332003849 heme pocket [chemical binding]; other site 83332003850 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 83332003851 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 83332003852 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 83332003853 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 83332003854 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 83332003855 anti sigma factor interaction site; other site 83332003856 regulatory phosphorylation site [posttranslational modification]; other site 83332003857 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 83332003858 anti sigma factor interaction site; other site 83332003859 regulatory phosphorylation site [posttranslational modification]; other site 83332003860 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 83332003861 synthetase active site [active] 83332003862 NTP binding site [chemical binding]; other site 83332003863 metal binding site [ion binding]; metal-binding site 83332003864 Beta-lactamase; Region: Beta-lactamase; pfam00144 83332003865 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 83332003866 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 83332003867 putative transposase OrfB; Reviewed; Region: PHA02517 83332003868 HTH-like domain; Region: HTH_21; pfam13276 83332003869 Integrase core domain; Region: rve; pfam00665 83332003870 Integrase core domain; Region: rve_3; pfam13683 83332003871 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 83332003872 Transposase; Region: HTH_Tnp_1; cl17663 83332003873 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; pfam00173 83332003874 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 83332003875 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 83332003876 putative di-iron ligands [ion binding]; other site 83332003877 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 83332003878 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 83332003879 malonyl-CoA binding site [chemical binding]; other site 83332003880 dimer interface [polypeptide binding]; other site 83332003881 active site 83332003882 product binding site; other site 83332003883 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 83332003884 uncharacterized domain; Region: TIGR00702 83332003885 YcaO-like family; Region: YcaO; pfam02624 83332003886 Uncharacterized conserved protein [Function unknown]; Region: COG3482 83332003887 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332003888 S-adenosylmethionine binding site [chemical binding]; other site 83332003889 Domain of unknown function (DUF222); Region: DUF222; pfam02720 83332003890 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 83332003891 active site 83332003892 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 83332003893 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 83332003894 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 83332003895 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 83332003896 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 83332003897 dihydroorotase; Validated; Region: pyrC; PRK09357 83332003898 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 83332003899 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 83332003900 active site 83332003901 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 83332003902 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 83332003903 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 83332003904 catalytic site [active] 83332003905 subunit interface [polypeptide binding]; other site 83332003906 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 83332003907 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 83332003908 ATP-grasp domain; Region: ATP-grasp_4; cl17255 83332003909 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 83332003910 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 83332003911 ATP-grasp domain; Region: ATP-grasp_4; cl17255 83332003912 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 83332003913 IMP binding site; other site 83332003914 dimer interface [polypeptide binding]; other site 83332003915 interdomain contacts; other site 83332003916 partial ornithine binding site; other site 83332003917 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 83332003918 active site 83332003919 dimer interface [polypeptide binding]; other site 83332003920 PE family; Region: PE; pfam00934 83332003921 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332003922 PPE family; Region: PPE; pfam00823 83332003923 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 83332003924 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 83332003925 catalytic site [active] 83332003926 G-X2-G-X-G-K; other site 83332003927 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 83332003928 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 83332003929 Flavoprotein; Region: Flavoprotein; pfam02441 83332003930 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 83332003931 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 83332003932 S-adenosylmethionine synthetase; Validated; Region: PRK05250 83332003933 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 83332003934 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 83332003935 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 83332003936 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 83332003937 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 83332003938 Cytochrome P450; Region: p450; cl12078 83332003939 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 83332003940 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 83332003941 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 83332003942 PE family; Region: PE; pfam00934 83332003943 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 83332003944 oligomeric interface; other site 83332003945 putative active site [active] 83332003946 homodimer interface [polypeptide binding]; other site 83332003947 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 83332003948 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 83332003949 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 83332003950 substrate binding pocket [chemical binding]; other site 83332003951 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 83332003952 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 83332003953 substrate binding pocket [chemical binding]; other site 83332003954 Predicted membrane protein [Function unknown]; Region: COG3714 83332003955 primosome assembly protein PriA; Provisional; Region: PRK14873 83332003956 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332003957 S-adenosylmethionine binding site [chemical binding]; other site 83332003958 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 83332003959 MarR family; Region: MarR; pfam01047 83332003960 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332003961 S-adenosylmethionine binding site [chemical binding]; other site 83332003962 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 83332003963 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 83332003964 putative active site [active] 83332003965 substrate binding site [chemical binding]; other site 83332003966 putative cosubstrate binding site; other site 83332003967 catalytic site [active] 83332003968 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 83332003969 substrate binding site [chemical binding]; other site 83332003970 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 83332003971 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 83332003972 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 83332003973 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 83332003974 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 83332003975 substrate binding site [chemical binding]; other site 83332003976 hexamer interface [polypeptide binding]; other site 83332003977 metal binding site [ion binding]; metal-binding site 83332003978 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 83332003979 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 83332003980 catalytic motif [active] 83332003981 Zn binding site [ion binding]; other site 83332003982 RibD C-terminal domain; Region: RibD_C; pfam01872 83332003983 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 83332003984 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 83332003985 putative substrate translocation pore; other site 83332003986 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 83332003987 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 83332003988 Lumazine binding domain; Region: Lum_binding; pfam00677 83332003989 Lumazine binding domain; Region: Lum_binding; pfam00677 83332003990 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 83332003991 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 83332003992 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 83332003993 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 83332003994 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 83332003995 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 83332003996 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 83332003997 dimerization interface [polypeptide binding]; other site 83332003998 active site 83332003999 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 83332004000 homopentamer interface [polypeptide binding]; other site 83332004001 active site 83332004002 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 83332004003 PknH-like extracellular domain; Region: PknH_C; pfam14032 83332004004 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 83332004005 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 83332004006 putative sugar binding sites [chemical binding]; other site 83332004007 Q-X-W motif; other site 83332004008 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 83332004009 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 83332004010 GIY-YIG motif/motif A; other site 83332004011 active site 83332004012 catalytic site [active] 83332004013 putative DNA binding site [nucleotide binding]; other site 83332004014 metal binding site [ion binding]; metal-binding site 83332004015 UvrB/uvrC motif; Region: UVR; pfam02151 83332004016 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 83332004017 Helix-hairpin-helix motif; Region: HHH; pfam00633 83332004018 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 83332004019 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 83332004020 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 83332004021 phosphate binding site [ion binding]; other site 83332004022 putative substrate binding pocket [chemical binding]; other site 83332004023 dimer interface [polypeptide binding]; other site 83332004024 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 83332004025 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 83332004026 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 83332004027 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 83332004028 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 83332004029 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 83332004030 acyl-CoA synthetase; Provisional; Region: PRK13382 83332004031 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 83332004032 acyl-activating enzyme (AAE) consensus motif; other site 83332004033 putative AMP binding site [chemical binding]; other site 83332004034 putative active site [active] 83332004035 putative CoA binding site [chemical binding]; other site 83332004036 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 83332004037 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 83332004038 putative acyl-acceptor binding pocket; other site 83332004039 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 83332004040 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 83332004041 PE family; Region: PE; pfam00934 83332004042 PE-PPE domain; Region: PE-PPE; pfam08237 83332004043 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 83332004044 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 83332004045 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 83332004046 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 83332004047 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 83332004048 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 83332004049 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 83332004050 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 83332004051 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 83332004052 Phosphoglycerate kinase; Region: PGK; pfam00162 83332004053 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 83332004054 substrate binding site [chemical binding]; other site 83332004055 hinge regions; other site 83332004056 ADP binding site [chemical binding]; other site 83332004057 catalytic site [active] 83332004058 triosephosphate isomerase; Provisional; Region: PRK14567 83332004059 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 83332004060 substrate binding site [chemical binding]; other site 83332004061 dimer interface [polypeptide binding]; other site 83332004062 catalytic triad [active] 83332004063 SnoaL-like domain; Region: SnoaL_2; pfam12680 83332004064 Preprotein translocase SecG subunit; Region: SecG; cl09123 83332004065 PE family; Region: PE; pfam00934 83332004066 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 83332004067 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 83332004068 molybdopterin cofactor binding site [chemical binding]; other site 83332004069 substrate binding site [chemical binding]; other site 83332004070 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 83332004071 molybdopterin cofactor binding site; other site 83332004072 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 83332004073 hydrophobic ligand binding site; other site 83332004074 Proteins of 100 residues with WXG; Region: WXG100; cl02005 83332004075 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 83332004076 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 83332004077 putative active site [active] 83332004078 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 83332004079 Glucose-6-P dehydrogenase subunit [Carbohydrate transport and metabolism]; Region: COG3429 83332004080 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 83332004081 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 83332004082 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 83332004083 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 83332004084 putative active site [active] 83332004085 transaldolase; Provisional; Region: PRK03903 83332004086 catalytic residue [active] 83332004087 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 83332004088 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 83332004089 TPP-binding site [chemical binding]; other site 83332004090 dimer interface [polypeptide binding]; other site 83332004091 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 83332004092 PYR/PP interface [polypeptide binding]; other site 83332004093 dimer interface [polypeptide binding]; other site 83332004094 TPP binding site [chemical binding]; other site 83332004095 PE family; Region: PE; pfam00934 83332004096 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 83332004097 UbiA prenyltransferase family; Region: UbiA; pfam01040 83332004098 PE family; Region: PE; pfam00934 83332004099 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 83332004100 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 83332004101 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 83332004102 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 83332004103 NADP binding site [chemical binding]; other site 83332004104 dimer interface [polypeptide binding]; other site 83332004105 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 83332004106 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 83332004107 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 83332004108 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 83332004109 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 83332004110 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 83332004111 Walker A/P-loop; other site 83332004112 ATP binding site [chemical binding]; other site 83332004113 Q-loop/lid; other site 83332004114 ABC transporter signature motif; other site 83332004115 Walker B; other site 83332004116 D-loop; other site 83332004117 H-loop/switch region; other site 83332004118 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 83332004119 Predicted transcriptional regulator [Transcription]; Region: COG2345 83332004120 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 83332004121 putative DNA binding site [nucleotide binding]; other site 83332004122 putative Zn2+ binding site [ion binding]; other site 83332004123 Transcriptional regulator PadR-like family; Region: PadR; cl17335 83332004124 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 83332004125 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 83332004126 protein-splicing catalytic site; other site 83332004127 thioester formation/cholesterol transfer; other site 83332004128 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 83332004129 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 83332004130 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 83332004131 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 83332004132 FeS assembly protein SufD; Region: sufD; TIGR01981 83332004133 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 83332004134 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 83332004135 Walker A/P-loop; other site 83332004136 ATP binding site [chemical binding]; other site 83332004137 Q-loop/lid; other site 83332004138 ABC transporter signature motif; other site 83332004139 Walker B; other site 83332004140 D-loop; other site 83332004141 H-loop/switch region; other site 83332004142 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 83332004143 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 83332004144 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 83332004145 catalytic residue [active] 83332004146 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 83332004147 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 83332004148 trimerization site [polypeptide binding]; other site 83332004149 active site 83332004150 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 83332004151 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 83332004152 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 83332004153 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 83332004154 active site 83332004155 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 83332004156 PE family; Region: PE; pfam00934 83332004157 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 83332004158 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 83332004159 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 83332004160 catalytic residues [active] 83332004161 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 83332004162 catalytic residues [active] 83332004163 enoyl-CoA hydratase; Provisional; Region: PRK05864 83332004164 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 83332004165 substrate binding site [chemical binding]; other site 83332004166 oxyanion hole (OAH) forming residues; other site 83332004167 trimer interface [polypeptide binding]; other site 83332004168 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 83332004169 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 83332004170 Walker A/P-loop; other site 83332004171 ATP binding site [chemical binding]; other site 83332004172 Q-loop/lid; other site 83332004173 ABC transporter signature motif; other site 83332004174 Walker B; other site 83332004175 D-loop; other site 83332004176 H-loop/switch region; other site 83332004177 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 83332004178 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332004179 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332004180 aconitate hydratase; Validated; Region: PRK09277 83332004181 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 83332004182 substrate binding site [chemical binding]; other site 83332004183 ligand binding site [chemical binding]; other site 83332004184 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 83332004185 substrate binding site [chemical binding]; other site 83332004186 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 83332004187 NlpC/P60 family; Region: NLPC_P60; pfam00877 83332004188 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 83332004189 NlpC/P60 family; Region: NLPC_P60; pfam00877 83332004190 MoxR-like ATPases [General function prediction only]; Region: COG0714 83332004191 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 83332004192 Walker A motif; other site 83332004193 ATP binding site [chemical binding]; other site 83332004194 Walker B motif; other site 83332004195 arginine finger; other site 83332004196 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 83332004197 Protein of unknown function DUF58; Region: DUF58; pfam01882 83332004198 hypothetical protein; Provisional; Region: PRK13685 83332004199 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 83332004200 metal ion-dependent adhesion site (MIDAS); other site 83332004201 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 83332004202 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 83332004203 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 83332004204 NAD(P) binding site [chemical binding]; other site 83332004205 homotetramer interface [polypeptide binding]; other site 83332004206 homodimer interface [polypeptide binding]; other site 83332004207 active site 83332004208 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 83332004209 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 83332004210 NAD binding site [chemical binding]; other site 83332004211 homotetramer interface [polypeptide binding]; other site 83332004212 homodimer interface [polypeptide binding]; other site 83332004213 substrate binding site [chemical binding]; other site 83332004214 active site 83332004215 ferrochelatase; Reviewed; Region: hemH; PRK00035 83332004216 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 83332004217 C-terminal domain interface [polypeptide binding]; other site 83332004218 active site 83332004219 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 83332004220 active site 83332004221 N-terminal domain interface [polypeptide binding]; other site 83332004222 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 83332004223 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 83332004224 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 83332004225 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 83332004226 Uncharacterized conserved protein [Function unknown]; Region: COG0398 83332004227 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 83332004228 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 83332004229 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 83332004230 heterodimer interface [polypeptide binding]; other site 83332004231 substrate interaction site [chemical binding]; other site 83332004232 Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding) [Lipid metabolism]; Region: Sbm; COG2185 83332004233 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 83332004234 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 83332004235 active site 83332004236 substrate binding site [chemical binding]; other site 83332004237 coenzyme B12 binding site [chemical binding]; other site 83332004238 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 83332004239 B12 binding site [chemical binding]; other site 83332004240 cobalt ligand [ion binding]; other site 83332004241 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 83332004242 membrane ATPase/protein kinase; Provisional; Region: PRK09435 83332004243 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 83332004244 Walker A; other site 83332004245 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 83332004246 Beta-lactamase; Region: Beta-lactamase; pfam00144 83332004247 Methyltransferase domain; Region: Methyltransf_31; pfam13847 83332004248 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332004249 S-adenosylmethionine binding site [chemical binding]; other site 83332004250 Uncharacterized conserved protein [Function unknown]; Region: COG3360 83332004251 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 83332004252 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 83332004253 Ligand binding site; other site 83332004254 Putative Catalytic site; other site 83332004255 DXD motif; other site 83332004256 Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5285 83332004257 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 83332004258 active site 83332004259 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 83332004260 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 83332004261 putative trimer interface [polypeptide binding]; other site 83332004262 putative CoA binding site [chemical binding]; other site 83332004263 Methyltransferase domain; Region: Methyltransf_12; pfam08242 83332004264 S-adenosylmethionine binding site [chemical binding]; other site 83332004265 WbqC-like protein family; Region: WbqC; pfam08889 83332004266 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 83332004267 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 83332004268 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 83332004269 Methyltransferase domain; Region: Methyltransf_23; pfam13489 83332004270 Methyltransferase domain; Region: Methyltransf_12; pfam08242 83332004271 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 83332004272 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 83332004273 NADP-binding site; other site 83332004274 homotetramer interface [polypeptide binding]; other site 83332004275 substrate binding site [chemical binding]; other site 83332004276 homodimer interface [polypeptide binding]; other site 83332004277 active site 83332004278 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 83332004279 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 83332004280 NADP binding site [chemical binding]; other site 83332004281 active site 83332004282 putative substrate binding site [chemical binding]; other site 83332004283 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 83332004284 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 83332004285 metal-binding site 83332004286 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332004287 S-adenosylmethionine binding site [chemical binding]; other site 83332004288 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 83332004289 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 83332004290 active site 83332004291 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 83332004292 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 83332004293 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 83332004294 active site 83332004295 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 83332004296 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 83332004297 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 83332004298 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 83332004299 active site 83332004300 acyl-CoA synthetase; Validated; Region: PRK05850 83332004301 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 83332004302 acyl-activating enzyme (AAE) consensus motif; other site 83332004303 active site 83332004304 Transport protein; Region: actII; TIGR00833 83332004305 Methyltransferase domain; Region: Methyltransf_23; pfam13489 83332004306 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332004307 S-adenosylmethionine binding site [chemical binding]; other site 83332004308 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 83332004309 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 83332004310 homodimer interface [polypeptide binding]; other site 83332004311 active site 83332004312 TDP-binding site; other site 83332004313 acceptor substrate-binding pocket; other site 83332004314 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 83332004315 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 83332004316 Probable Catalytic site; other site 83332004317 metal-binding site 83332004318 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 83332004319 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 83332004320 homodimer interface [polypeptide binding]; other site 83332004321 active site 83332004322 TDP-binding site; other site 83332004323 acceptor substrate-binding pocket; other site 83332004324 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 83332004325 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 83332004326 active site 83332004327 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 83332004328 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 83332004329 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 83332004330 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 83332004331 Enoylreductase; Region: PKS_ER; smart00829 83332004332 NAD(P) binding site [chemical binding]; other site 83332004333 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 83332004334 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 83332004335 putative NADP binding site [chemical binding]; other site 83332004336 active site 83332004337 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 83332004338 acyl-CoA synthetase; Validated; Region: PRK05850 83332004339 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 83332004340 acyl-activating enzyme (AAE) consensus motif; other site 83332004341 active site 83332004342 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 83332004343 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 83332004344 NAD(P) binding site [chemical binding]; other site 83332004345 Uncharacterized conserved protein [Function unknown]; Region: COG2128 83332004346 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 83332004347 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 83332004348 CoenzymeA binding site [chemical binding]; other site 83332004349 subunit interaction site [polypeptide binding]; other site 83332004350 PHB binding site; other site 83332004351 Nitronate monooxygenase; Region: NMO; pfam03060 83332004352 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 83332004353 FMN binding site [chemical binding]; other site 83332004354 substrate binding site [chemical binding]; other site 83332004355 putative catalytic residue [active] 83332004356 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332004357 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 83332004358 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 83332004359 HIGH motif; other site 83332004360 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 83332004361 active site 83332004362 KMSKS motif; other site 83332004363 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 83332004364 tRNA binding surface [nucleotide binding]; other site 83332004365 anticodon binding site; other site 83332004366 DNA polymerase IV; Provisional; Region: PRK03348 83332004367 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 83332004368 active site 83332004369 DNA binding site [nucleotide binding] 83332004370 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 83332004371 active site 83332004372 homodimer interface [polypeptide binding]; other site 83332004373 homotetramer interface [polypeptide binding]; other site 83332004374 lipoprotein signal peptidase; Provisional; Region: PRK14764 83332004375 lipoprotein signal peptidase; Provisional; Region: PRK14787 83332004376 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 83332004377 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 83332004378 active site 83332004379 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 83332004380 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 83332004381 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 83332004382 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 83332004383 apolar tunnel; other site 83332004384 heme binding site [chemical binding]; other site 83332004385 dimerization interface [polypeptide binding]; other site 83332004386 short chain dehydrogenase; Provisional; Region: PRK05866 83332004387 classical (c) SDRs; Region: SDR_c; cd05233 83332004388 NAD(P) binding site [chemical binding]; other site 83332004389 active site 83332004390 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 83332004391 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 83332004392 NAD(P) binding site [chemical binding]; other site 83332004393 active site 83332004394 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 83332004395 hydrophobic ligand binding site; other site 83332004396 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 83332004397 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 83332004398 active site 83332004399 PHP Thumb interface [polypeptide binding]; other site 83332004400 metal binding site [ion binding]; metal-binding site 83332004401 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 83332004402 generic binding surface II; other site 83332004403 generic binding surface I; other site 83332004404 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332004405 PPE family; Region: PPE; pfam00823 83332004406 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332004407 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332004408 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 83332004409 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 83332004410 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 83332004411 acyl-activating enzyme (AAE) consensus motif; other site 83332004412 putative AMP binding site [chemical binding]; other site 83332004413 putative active site [active] 83332004414 putative CoA binding site [chemical binding]; other site 83332004415 glycerol-3-phosphate acyltransferase; Reviewed; Region: PRK11915 83332004416 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 83332004417 putative acyl-acceptor binding pocket; other site 83332004418 fumarate reductase, flavoprotein subunit; Region: fum_red_Fp; TIGR01176 83332004419 L-aspartate oxidase; Provisional; Region: PRK06175 83332004420 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 83332004421 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 83332004422 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 83332004423 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 83332004424 D-subunit interface [polypeptide binding]; other site 83332004425 Iron-sulfur protein interface; other site 83332004426 proximal quinone binding site [chemical binding]; other site 83332004427 distal quinone binding site [chemical binding]; other site 83332004428 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 83332004429 Iron-sulfur protein interface; other site 83332004430 proximal quinone binding site [chemical binding]; other site 83332004431 C-subunit interface; other site 83332004432 distal quinone binding site; other site 83332004433 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332004434 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332004435 MMPL family; Region: MMPL; pfam03176 83332004436 Domain of unknown function (DUF385); Region: DUF385; pfam04075 83332004437 threonine dehydratase; Validated; Region: PRK08639 83332004438 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 83332004439 tetramer interface [polypeptide binding]; other site 83332004440 pyridoxal 5'-phosphate binding site [chemical binding]; other site 83332004441 catalytic residue [active] 83332004442 C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585 83332004443 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 83332004444 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 83332004445 putative active site [active] 83332004446 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 83332004447 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 83332004448 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 83332004449 catalytic site [active] 83332004450 active site 83332004451 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 83332004452 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 83332004453 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 83332004454 active site 83332004455 catalytic site [active] 83332004456 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 83332004457 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 83332004458 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 83332004459 active site 83332004460 catalytic site [active] 83332004461 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 83332004462 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 83332004463 NlpC/P60 family; Region: NLPC_P60; pfam00877 83332004464 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 83332004465 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 83332004466 inhibitor-cofactor binding pocket; inhibition site 83332004467 pyridoxal 5'-phosphate binding site [chemical binding]; other site 83332004468 catalytic residue [active] 83332004469 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 83332004470 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 83332004471 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 83332004472 catalytic residue [active] 83332004473 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 83332004474 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 83332004475 Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653 83332004476 Phage capsid family; Region: Phage_capsid; pfam05065 83332004477 Phage head maturation protease [General function prediction only]; Region: COG3740 83332004478 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: COG3747 83332004479 Phage associated DNA primase [General function prediction only]; Region: COG3378 83332004480 D5 N terminal like; Region: D5_N; smart00885 83332004481 Protein of unknown function (DUF2742); Region: DUF2742; pfam10888 83332004482 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 83332004483 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 83332004484 catalytic residues [active] 83332004485 catalytic nucleophile [active] 83332004486 Recombinase; Region: Recombinase; pfam07508 83332004487 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 83332004488 Domain of unknown function (DUF222); Region: DUF222; pfam02720 83332004489 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 83332004490 active site 83332004491 Domain of unknown function (DUF222); Region: DUF222; pfam02720 83332004492 biotin synthase; Validated; Region: PRK06256 83332004493 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 83332004494 FeS/SAM binding site; other site 83332004495 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 83332004496 Protein of unknown function (DUF2567); Region: DUF2567; pfam10821 83332004497 Secretory lipase; Region: LIP; pfam03583 83332004498 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 83332004499 nudix motif; other site 83332004500 quinolinate synthetase; Provisional; Region: PRK09375 83332004501 L-aspartate oxidase; Provisional; Region: PRK07804 83332004502 L-aspartate oxidase; Provisional; Region: PRK06175 83332004503 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 83332004504 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 83332004505 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 83332004506 dimerization interface [polypeptide binding]; other site 83332004507 active site 83332004508 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332004509 S-adenosylmethionine binding site [chemical binding]; other site 83332004510 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 83332004511 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 83332004512 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 83332004513 NAD binding site [chemical binding]; other site 83332004514 dimerization interface [polypeptide binding]; other site 83332004515 product binding site; other site 83332004516 substrate binding site [chemical binding]; other site 83332004517 zinc binding site [ion binding]; other site 83332004518 catalytic residues [active] 83332004519 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 83332004520 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 83332004521 pyridoxal 5'-phosphate binding site [chemical binding]; other site 83332004522 homodimer interface [polypeptide binding]; other site 83332004523 catalytic residue [active] 83332004524 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 83332004525 4-fold oligomerization interface [polypeptide binding]; other site 83332004526 putative active site pocket [active] 83332004527 metal binding residues [ion binding]; metal-binding site 83332004528 3-fold/trimer interface [polypeptide binding]; other site 83332004529 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 83332004530 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 83332004531 putative active site [active] 83332004532 oxyanion strand; other site 83332004533 catalytic triad [active] 83332004534 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 83332004535 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 83332004536 catalytic residues [active] 83332004537 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 83332004538 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 83332004539 active site 83332004540 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 83332004541 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 83332004542 substrate binding site [chemical binding]; other site 83332004543 glutamase interaction surface [polypeptide binding]; other site 83332004544 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 83332004545 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 83332004546 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 83332004547 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 83332004548 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 83332004549 catalytic triad [active] 83332004550 anthranilate synthase component I; Provisional; Region: PRK13571 83332004551 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 83332004552 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 83332004553 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 83332004554 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 83332004555 active site 83332004556 ribulose/triose binding site [chemical binding]; other site 83332004557 phosphate binding site [ion binding]; other site 83332004558 substrate (anthranilate) binding pocket [chemical binding]; other site 83332004559 product (indole) binding pocket [chemical binding]; other site 83332004560 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 83332004561 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 83332004562 pyridoxal 5'-phosphate binding site [chemical binding]; other site 83332004563 catalytic residue [active] 83332004564 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 83332004565 substrate binding site [chemical binding]; other site 83332004566 active site 83332004567 catalytic residues [active] 83332004568 heterodimer interface [polypeptide binding]; other site 83332004569 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108 83332004570 Prolipoprotein diacylglyceryltransferase [Cell envelope biogenesis, outer membrane]; Region: Lgt; COG0682 83332004571 TM2 domain; Region: TM2; pfam05154 83332004572 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 83332004573 pyruvate kinase; Provisional; Region: PRK06247 83332004574 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 83332004575 domain interfaces; other site 83332004576 active site 83332004577 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 83332004578 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 83332004579 active site 83332004580 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 83332004581 catalytic triad [active] 83332004582 dimer interface [polypeptide binding]; other site 83332004583 Uncharacterized conserved protein [Function unknown]; Region: COG2898 83332004584 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 83332004585 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 83332004586 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 83332004587 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 83332004588 Walker A/P-loop; other site 83332004589 Walker A/P-loop; other site 83332004590 ATP binding site [chemical binding]; other site 83332004591 ATP binding site [chemical binding]; other site 83332004592 Q-loop/lid; other site 83332004593 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 83332004594 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 83332004595 Walker A/P-loop; other site 83332004596 ATP binding site [chemical binding]; other site 83332004597 Q-loop/lid; other site 83332004598 ABC transporter signature motif; other site 83332004599 Walker B; other site 83332004600 D-loop; other site 83332004601 H-loop/switch region; other site 83332004602 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 83332004603 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 83332004604 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 83332004605 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 83332004606 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 83332004607 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 83332004608 cyclase homology domain; Region: CHD; cd07302 83332004609 nucleotidyl binding site; other site 83332004610 metal binding site [ion binding]; metal-binding site 83332004611 dimer interface [polypeptide binding]; other site 83332004612 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 83332004613 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 83332004614 active site 83332004615 phosphorylation site [posttranslational modification] 83332004616 intermolecular recognition site; other site 83332004617 dimerization interface [polypeptide binding]; other site 83332004618 ANTAR domain; Region: ANTAR; pfam03861 83332004619 lipid-transfer protein; Provisional; Region: PRK06059 83332004620 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 83332004621 active site 83332004622 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 83332004623 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 83332004624 DUF35 OB-fold domain; Region: DUF35; pfam01796 83332004625 DNA polymerase I; Provisional; Region: PRK05755 83332004626 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 83332004627 active site 83332004628 metal binding site 1 [ion binding]; metal-binding site 83332004629 putative 5' ssDNA interaction site; other site 83332004630 metal binding site 3; metal-binding site 83332004631 metal binding site 2 [ion binding]; metal-binding site 83332004632 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 83332004633 putative DNA binding site [nucleotide binding]; other site 83332004634 putative metal binding site [ion binding]; other site 83332004635 3'-5' exonuclease; Region: 35EXOc; smart00474 83332004636 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 83332004637 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 83332004638 active site 83332004639 DNA binding site [nucleotide binding] 83332004640 catalytic site [active] 83332004641 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 83332004642 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 83332004643 RNA binding site [nucleotide binding]; other site 83332004644 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 83332004645 RNA binding site [nucleotide binding]; other site 83332004646 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 83332004647 RNA binding site [nucleotide binding]; other site 83332004648 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 83332004649 RNA binding site [nucleotide binding]; other site 83332004650 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 83332004651 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 83332004652 CoA-binding site [chemical binding]; other site 83332004653 ATP-binding [chemical binding]; other site 83332004654 Uncharacterized conserved protein [Function unknown]; Region: GrpB; COG2320 83332004655 Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306 83332004656 excinuclease ABC subunit B; Provisional; Region: PRK05298 83332004657 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 83332004658 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 83332004659 nucleotide binding region [chemical binding]; other site 83332004660 ATP-binding site [chemical binding]; other site 83332004661 Ultra-violet resistance protein B; Region: UvrB; pfam12344 83332004662 UvrB/uvrC motif; Region: UVR; pfam02151 83332004663 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 83332004664 Major Facilitator Superfamily; Region: MFS_1; pfam07690 83332004665 putative substrate translocation pore; other site 83332004666 Predicted membrane protein [Function unknown]; Region: COG5305 83332004667 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 83332004668 Ligand Binding Site [chemical binding]; other site 83332004669 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 83332004670 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 83332004671 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 83332004672 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 83332004673 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 83332004674 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 83332004675 Predicted esterase [General function prediction only]; Region: COG0627 83332004676 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 83332004677 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 83332004678 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 83332004679 dimer interface [polypeptide binding]; other site 83332004680 putative anticodon binding site; other site 83332004681 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 83332004682 motif 1; other site 83332004683 dimer interface [polypeptide binding]; other site 83332004684 active site 83332004685 motif 2; other site 83332004686 motif 3; other site 83332004687 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 83332004688 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 83332004689 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 83332004690 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 83332004691 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 83332004692 23S rRNA binding site [nucleotide binding]; other site 83332004693 L21 binding site [polypeptide binding]; other site 83332004694 L13 binding site [polypeptide binding]; other site 83332004695 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 83332004696 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 83332004697 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 83332004698 PE family; Region: PE; pfam00934 83332004699 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 83332004700 cyclase homology domain; Region: CHD; cd07302 83332004701 nucleotidyl binding site; other site 83332004702 metal binding site [ion binding]; metal-binding site 83332004703 dimer interface [polypeptide binding]; other site 83332004704 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 83332004705 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 83332004706 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 83332004707 dimer interface [polypeptide binding]; other site 83332004708 motif 1; other site 83332004709 active site 83332004710 motif 2; other site 83332004711 motif 3; other site 83332004712 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 83332004713 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 83332004714 putative tRNA-binding site [nucleotide binding]; other site 83332004715 B3/4 domain; Region: B3_4; pfam03483 83332004716 tRNA synthetase B5 domain; Region: B5; smart00874 83332004717 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 83332004718 dimer interface [polypeptide binding]; other site 83332004719 motif 1; other site 83332004720 motif 3; other site 83332004721 motif 2; other site 83332004722 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 83332004723 PE family; Region: PE; pfam00934 83332004724 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 83332004725 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 83332004726 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 83332004727 heterotetramer interface [polypeptide binding]; other site 83332004728 active site pocket [active] 83332004729 cleavage site 83332004730 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 83332004731 feedback inhibition sensing region; other site 83332004732 homohexameric interface [polypeptide binding]; other site 83332004733 nucleotide binding site [chemical binding]; other site 83332004734 N-acetyl-L-glutamate binding site [chemical binding]; other site 83332004735 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 83332004736 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 83332004737 inhibitor-cofactor binding pocket; inhibition site 83332004738 pyridoxal 5'-phosphate binding site [chemical binding]; other site 83332004739 catalytic residue [active] 83332004740 ornithine carbamoyltransferase; Provisional; Region: PRK00779 83332004741 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 83332004742 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 83332004743 arginine repressor; Provisional; Region: PRK03341 83332004744 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 83332004745 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 83332004746 argininosuccinate synthase; Provisional; Region: PRK13820 83332004747 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 83332004748 ANP binding site [chemical binding]; other site 83332004749 Substrate Binding Site II [chemical binding]; other site 83332004750 Substrate Binding Site I [chemical binding]; other site 83332004751 argininosuccinate lyase; Provisional; Region: PRK00855 83332004752 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 83332004753 active sites [active] 83332004754 tetramer interface [polypeptide binding]; other site 83332004755 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 83332004756 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 83332004757 malonyl-CoA binding site [chemical binding]; other site 83332004758 dimer interface [polypeptide binding]; other site 83332004759 active site 83332004760 product binding site; other site 83332004761 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 83332004762 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 83332004763 active site 83332004764 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 83332004765 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 83332004766 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 83332004767 Enoylreductase; Region: PKS_ER; smart00829 83332004768 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 83332004769 NAD(P) binding site [chemical binding]; other site 83332004770 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 83332004771 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 83332004772 putative NADP binding site [chemical binding]; other site 83332004773 active site 83332004774 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 83332004775 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 83332004776 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 83332004777 active site 83332004778 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 83332004779 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 83332004780 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 83332004781 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 83332004782 Enoylreductase; Region: PKS_ER; smart00829 83332004783 NAD(P) binding site [chemical binding]; other site 83332004784 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 83332004785 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 83332004786 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 83332004787 putative NADP binding site [chemical binding]; other site 83332004788 active site 83332004789 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 83332004790 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 83332004791 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 83332004792 active site 83332004793 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 83332004794 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 83332004795 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 83332004796 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 83332004797 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 83332004798 malonyl-CoA binding site [chemical binding]; other site 83332004799 dimer interface [polypeptide binding]; other site 83332004800 active site 83332004801 product binding site; other site 83332004802 Cytochrome P450; Region: p450; cl12078 83332004803 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 83332004804 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 83332004805 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 83332004806 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 83332004807 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 83332004808 ABC transporter; Region: ABC_tran_2; pfam12848 83332004809 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 83332004810 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 83332004811 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 83332004812 putative substrate translocation pore; other site 83332004813 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 83332004814 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 83332004815 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 83332004816 dimerization interface [polypeptide binding]; other site 83332004817 putative DNA binding site [nucleotide binding]; other site 83332004818 putative Zn2+ binding site [ion binding]; other site 83332004819 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 83332004820 active site residue [active] 83332004821 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 83332004822 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 83332004823 ligand binding site [chemical binding]; other site 83332004824 flexible hinge region; other site 83332004825 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 83332004826 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 83332004827 putative catalytic residues [active] 83332004828 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 83332004829 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 83332004830 catalytic residues [active] 83332004831 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332004832 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 83332004833 active site 83332004834 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 83332004835 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 83332004836 substrate binding pocket [chemical binding]; other site 83332004837 membrane-bound complex binding site; other site 83332004838 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 83332004839 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 83332004840 FeS/SAM binding site; other site 83332004841 DivIVA protein; Region: DivIVA; pfam05103 83332004842 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 83332004843 acyl-CoA synthetase; Validated; Region: PRK07868 83332004844 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 83332004845 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 83332004846 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 83332004847 acyl-activating enzyme (AAE) consensus motif; other site 83332004848 AMP binding site [chemical binding]; other site 83332004849 active site 83332004850 CoA binding site [chemical binding]; other site 83332004851 Uncharacterized conserved protein [Function unknown]; Region: COG2835 83332004852 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332004853 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332004854 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 83332004855 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 83332004856 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 83332004857 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 83332004858 Walker A/P-loop; other site 83332004859 ATP binding site [chemical binding]; other site 83332004860 Q-loop/lid; other site 83332004861 ABC transporter signature motif; other site 83332004862 Walker B; other site 83332004863 D-loop; other site 83332004864 H-loop/switch region; other site 83332004865 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 83332004866 active site 83332004867 DNA binding site [nucleotide binding] 83332004868 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 83332004869 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 83332004870 active site 83332004871 HIGH motif; other site 83332004872 dimer interface [polypeptide binding]; other site 83332004873 KMSKS motif; other site 83332004874 S4 RNA-binding domain; Region: S4; smart00363 83332004875 RNA binding surface [nucleotide binding]; other site 83332004876 Protein of unknown function (DUF732); Region: DUF732; pfam05305 83332004877 Tetratrico peptide repeat; Region: TPR_5; pfam12688 83332004878 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 83332004879 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 83332004880 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 83332004881 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 83332004882 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 83332004883 RNA binding surface [nucleotide binding]; other site 83332004884 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332004885 S-adenosylmethionine binding site [chemical binding]; other site 83332004886 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 83332004887 ATP-NAD kinase; Region: NAD_kinase; pfam01513 83332004888 DNA repair protein RecN; Region: recN; TIGR00634 83332004889 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 83332004890 Walker A/P-loop; other site 83332004891 ATP binding site [chemical binding]; other site 83332004892 Q-loop/lid; other site 83332004893 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 83332004894 ABC transporter signature motif; other site 83332004895 Walker B; other site 83332004896 D-loop; other site 83332004897 H-loop/switch region; other site 83332004898 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 83332004899 Thiamine pyrophosphokinase; Region: TPK; cl08415 83332004900 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 83332004901 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 83332004902 CTP synthetase; Validated; Region: pyrG; PRK05380 83332004903 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 83332004904 Catalytic site [active] 83332004905 active site 83332004906 UTP binding site [chemical binding]; other site 83332004907 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 83332004908 active site 83332004909 putative oxyanion hole; other site 83332004910 catalytic triad [active] 83332004911 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 83332004912 dimer interface [polypeptide binding]; other site 83332004913 ADP-ribose binding site [chemical binding]; other site 83332004914 active site 83332004915 nudix motif; other site 83332004916 metal binding site [ion binding]; metal-binding site 83332004917 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 83332004918 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 83332004919 active site 83332004920 DNA binding site [nucleotide binding] 83332004921 Int/Topo IB signature motif; other site 83332004922 Domain of unknown function (DUF222); Region: DUF222; pfam02720 83332004923 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 83332004924 active site 83332004925 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 83332004926 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332004927 S-adenosylmethionine binding site [chemical binding]; other site 83332004928 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 83332004929 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332004930 PPE family; Region: PPE; pfam00823 83332004931 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 83332004932 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332004933 PPE family; Region: PPE; pfam00823 83332004934 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 83332004935 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 83332004936 Sulfate transporter family; Region: Sulfate_transp; pfam00916 83332004937 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 83332004938 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 83332004939 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 83332004940 P-loop; other site 83332004941 Magnesium ion binding site [ion binding]; other site 83332004942 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 83332004943 Magnesium ion binding site [ion binding]; other site 83332004944 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 83332004945 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 83332004946 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 83332004947 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 83332004948 RNA binding surface [nucleotide binding]; other site 83332004949 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 83332004950 active site 83332004951 cytidylate kinase; Provisional; Region: cmk; PRK00023 83332004952 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 83332004953 CMP-binding site; other site 83332004954 The sites determining sugar specificity; other site 83332004955 GTP-binding protein Der; Reviewed; Region: PRK03003 83332004956 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 83332004957 GTP/Mg2+ binding site [chemical binding]; other site 83332004958 Switch I region; other site 83332004959 G2 box; other site 83332004960 Switch II region; other site 83332004961 G3 box; other site 83332004962 G4 box; other site 83332004963 G5 box; other site 83332004964 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 83332004965 G1 box; other site 83332004966 GTP/Mg2+ binding site [chemical binding]; other site 83332004967 Switch I region; other site 83332004968 G2 box; other site 83332004969 G3 box; other site 83332004970 Switch II region; other site 83332004971 G4 box; other site 83332004972 G5 box; other site 83332004973 short chain dehydrogenase; Provisional; Region: PRK07060 83332004974 classical (c) SDRs; Region: SDR_c; cd05233 83332004975 NAD(P) binding site [chemical binding]; other site 83332004976 active site 83332004977 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 83332004978 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 83332004979 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 83332004980 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 83332004981 Cupin domain; Region: Cupin_2; pfam07883 83332004982 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 83332004983 Transcriptional regulator [Transcription]; Region: IclR; COG1414 83332004984 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 83332004985 putative switch regulator; other site 83332004986 non-specific DNA interactions [nucleotide binding]; other site 83332004987 DNA binding site [nucleotide binding] 83332004988 sequence specific DNA binding site [nucleotide binding]; other site 83332004989 putative cAMP binding site [chemical binding]; other site 83332004990 Bacterial transcriptional regulator; Region: IclR; pfam01614 83332004991 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 83332004992 putative active site [active] 83332004993 homotetrameric interface [polypeptide binding]; other site 83332004994 metal binding site [ion binding]; metal-binding site 83332004995 biotin carboxylase-like protein; Validated; Region: PRK06524 83332004996 ATP-grasp domain; Region: ATP-grasp_4; cl17255 83332004997 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 83332004998 Beta-lactamase; Region: Beta-lactamase; pfam00144 83332004999 Predicted transcriptional regulators [Transcription]; Region: COG1733 83332005000 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 83332005001 dimerization interface [polypeptide binding]; other site 83332005002 putative DNA binding site [nucleotide binding]; other site 83332005003 putative Zn2+ binding site [ion binding]; other site 83332005004 Predicted transcriptional regulators [Transcription]; Region: COG1733 83332005005 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 83332005006 FAD binding domain; Region: FAD_binding_4; pfam01565 83332005007 Berberine and berberine like; Region: BBE; pfam08031 83332005008 TIGR03086 family protein; Region: TIGR03086 83332005009 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 83332005010 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 83332005011 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 83332005012 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 83332005013 Beta-lactamase; Region: Beta-lactamase; pfam00144 83332005014 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 83332005015 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 83332005016 NAD(P) binding site [chemical binding]; other site 83332005017 catalytic residues [active] 83332005018 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 83332005019 putative catalytic residue [active] 83332005020 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 83332005021 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 83332005022 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 83332005023 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 83332005024 gating phenylalanine in ion channel; other site 83332005025 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 83332005026 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 83332005027 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 83332005028 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 83332005029 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 83332005030 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 83332005031 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 83332005032 putative substrate translocation pore; other site 83332005033 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 83332005034 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 83332005035 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 83332005036 Sulfate transporter family; Region: Sulfate_transp; pfam00916 83332005037 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 83332005038 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 83332005039 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3742 83332005040 putative active site [active] 83332005041 Protein tyrosine kinase; Region: Pkinase_Tyr; pfam07714 83332005042 Catalytic domain of Protein Kinases; Region: PKc; cd00180 83332005043 active site 83332005044 ATP binding site [chemical binding]; other site 83332005045 substrate binding site [chemical binding]; other site 83332005046 activation loop (A-loop); other site 83332005047 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 83332005048 Thioredoxin; Region: Thioredoxin_4; cl17273 83332005049 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 83332005050 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 83332005051 active site 83332005052 metal binding site [ion binding]; metal-binding site 83332005053 nudix motif; other site 83332005054 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 83332005055 Catalytic domain of Protein Kinases; Region: PKc; cd00180 83332005056 active site 83332005057 ATP binding site [chemical binding]; other site 83332005058 substrate binding site [chemical binding]; other site 83332005059 activation loop (A-loop); other site 83332005060 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 83332005061 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 83332005062 phosphopeptide binding site; other site 83332005063 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 83332005064 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 83332005065 phosphopeptide binding site; other site 83332005066 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 83332005067 The Eye Pigment Precursor Transporter (EPP) Family protein; Region: 3a01204; TIGR00955 83332005068 Walker A/P-loop; other site 83332005069 ATP binding site [chemical binding]; other site 83332005070 Q-loop/lid; other site 83332005071 ABC transporter signature motif; other site 83332005072 Walker B; other site 83332005073 D-loop; other site 83332005074 H-loop/switch region; other site 83332005075 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 83332005076 acyl-CoA synthetase; Provisional; Region: PRK13388 83332005077 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 83332005078 acyl-activating enzyme (AAE) consensus motif; other site 83332005079 AMP binding site [chemical binding]; other site 83332005080 active site 83332005081 CoA binding site [chemical binding]; other site 83332005082 hypothetical protein; Provisional; Region: PRK06185 83332005083 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 83332005084 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 83332005085 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 83332005086 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332005087 PPE family; Region: PPE; pfam00823 83332005088 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332005089 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332005090 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 83332005091 Phosphoesterase family; Region: Phosphoesterase; pfam04185 83332005092 putative transposase OrfB; Reviewed; Region: PHA02517 83332005093 HTH-like domain; Region: HTH_21; pfam13276 83332005094 Integrase core domain; Region: rve; pfam00665 83332005095 Integrase core domain; Region: rve_3; pfam13683 83332005096 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 83332005097 Transposase; Region: HTH_Tnp_1; cl17663 83332005098 Cutinase; Region: Cutinase; pfam01083 83332005099 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 83332005100 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 83332005101 Uncharacterized conserved protein [Function unknown]; Region: COG0393 83332005102 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 83332005103 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 83332005104 Transposase; Region: HTH_Tnp_1; cl17663 83332005105 putative transposase OrfB; Reviewed; Region: PHA02517 83332005106 HTH-like domain; Region: HTH_21; pfam13276 83332005107 Integrase core domain; Region: rve; pfam00665 83332005108 Integrase core domain; Region: rve_3; pfam13683 83332005109 Domain of unknown function (DUF222); Region: DUF222; pfam02720 83332005110 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 83332005111 active site 83332005112 Integrase core domain; Region: rve; pfam00665 83332005113 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 83332005114 putative homotetramer interface [polypeptide binding]; other site 83332005115 putative homodimer interface [polypeptide binding]; other site 83332005116 putative allosteric switch controlling residues; other site 83332005117 putative metal binding site [ion binding]; other site 83332005118 putative homodimer-homodimer interface [polypeptide binding]; other site 83332005119 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 83332005120 PE family; Region: PE; pfam00934 83332005121 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 83332005122 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 83332005123 dimer interface [polypeptide binding]; other site 83332005124 active site 83332005125 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 83332005126 substrate binding site [chemical binding]; other site 83332005127 catalytic residue [active] 83332005128 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 83332005129 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 83332005130 metal binding site [ion binding]; metal-binding site 83332005131 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 83332005132 FAD binding domain; Region: FAD_binding_4; pfam01565 83332005133 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 83332005134 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 83332005135 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 83332005136 Transcriptional regulator [Transcription]; Region: IclR; COG1414 83332005137 Bacterial transcriptional regulator; Region: IclR; pfam01614 83332005138 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 83332005139 FAD binding domain; Region: FAD_binding_4; pfam01565 83332005140 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332005141 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332005142 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 83332005143 Cytochrome P450; Region: p450; cl12078 83332005144 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 83332005145 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 83332005146 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 83332005147 Protein of unknown function (DUF690); Region: DUF690; pfam05108 83332005148 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 83332005149 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 83332005150 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 83332005151 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 83332005152 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 83332005153 Cytochrome P450; Region: p450; cl12078 83332005154 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 83332005155 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332005156 PPE family; Region: PPE; pfam00823 83332005157 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 83332005158 PE family; Region: PE; pfam00934 83332005159 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332005160 PPE family; Region: PPE; pfam00823 83332005161 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 83332005162 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332005163 PPE family; Region: PPE; pfam00823 83332005164 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 83332005165 PE family; Region: PE; pfam00934 83332005166 Proteins of 100 residues with WXG; Region: WXG100; cl02005 83332005167 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 83332005168 EspG family; Region: ESX-1_EspG; pfam14011 83332005169 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 83332005170 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 83332005171 catalytic residues [active] 83332005172 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 83332005173 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 83332005174 active site 83332005175 catalytic residues [active] 83332005176 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 83332005177 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 83332005178 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 83332005179 Walker A motif; other site 83332005180 ATP binding site [chemical binding]; other site 83332005181 Walker B motif; other site 83332005182 arginine finger; other site 83332005183 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332005184 PPE family; Region: PPE; pfam00823 83332005185 PE-PPE domain; Region: PE-PPE; pfam08237 83332005186 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332005187 PPE family; Region: PPE; pfam00823 83332005188 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332005189 PPE family; Region: PPE; pfam00823 83332005190 PE family; Region: PE; pfam00934 83332005191 Protein of unknown function (DUF732); Region: DUF732; pfam05305 83332005192 PE family; Region: PE; pfam00934 83332005193 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332005194 PPE family; Region: PPE; pfam00823 83332005195 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332005196 PPE family; Region: PPE; pfam00823 83332005197 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332005198 PPE family; Region: PPE; pfam00823 83332005199 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 83332005200 Protein of unknown function (DUF732); Region: DUF732; pfam05305 83332005201 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 83332005202 MgtC family; Region: MgtC; pfam02308 83332005203 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 83332005204 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 83332005205 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 83332005206 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 83332005207 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 83332005208 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332005209 hypothetical protein; Validated; Region: PRK07121 83332005210 PE family; Region: PE; pfam00934 83332005211 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 83332005212 ABC transporter transmembrane region 2; Region: ABC_membrane_2; pfam06472 83332005213 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 83332005214 hypothetical protein; Provisional; Region: PRK05858 83332005215 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 83332005216 PYR/PP interface [polypeptide binding]; other site 83332005217 dimer interface [polypeptide binding]; other site 83332005218 TPP binding site [chemical binding]; other site 83332005219 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 83332005220 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 83332005221 TPP-binding site; other site 83332005222 dimer interface [polypeptide binding]; other site 83332005223 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 83332005224 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 83332005225 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 83332005226 nucleotide binding region [chemical binding]; other site 83332005227 ATP-binding site [chemical binding]; other site 83332005228 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 83332005229 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 83332005230 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 83332005231 Uncharacterized conserved protein (small basic protein) [Function unknown]; Region: Sbp; COG3856 83332005232 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 83332005233 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 83332005234 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 83332005235 lipoyl attachment site [posttranslational modification]; other site 83332005236 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 83332005237 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 83332005238 phosphopeptide binding site; other site 83332005239 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 83332005240 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 83332005241 DNA binding residues [nucleotide binding] 83332005242 Bifunctional nuclease; Region: DNase-RNase; pfam02577 83332005243 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 83332005244 DNA binding residues [nucleotide binding] 83332005245 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 83332005246 putative dimer interface [polypeptide binding]; other site 83332005247 glycine dehydrogenase; Provisional; Region: PRK05367 83332005248 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 83332005249 pyridoxal 5'-phosphate binding site [chemical binding]; other site 83332005250 tetramer interface [polypeptide binding]; other site 83332005251 catalytic residue [active] 83332005252 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 83332005253 tetramer interface [polypeptide binding]; other site 83332005254 pyridoxal 5'-phosphate binding site [chemical binding]; other site 83332005255 catalytic residue [active] 83332005256 haloalkane dehalogenase; Provisional; Region: PRK03204 83332005257 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 83332005258 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 83332005259 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 83332005260 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 83332005261 metal ion-dependent adhesion site (MIDAS); other site 83332005262 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 83332005263 active site 83332005264 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 83332005265 putative active site [active] 83332005266 Domain of unknown function DUF21; Region: DUF21; pfam01595 83332005267 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 83332005268 FOG: CBS domain [General function prediction only]; Region: COG0517 83332005269 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 83332005270 Domain of unknown function DUF21; Region: DUF21; pfam01595 83332005271 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 83332005272 Transporter associated domain; Region: CorC_HlyC; smart01091 83332005273 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 83332005274 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 83332005275 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 83332005276 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 83332005277 active site 83332005278 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 83332005279 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 83332005280 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 83332005281 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 83332005282 Predicted transcriptional regulator [Transcription]; Region: COG3682 83332005283 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 83332005284 CoenzymeA binding site [chemical binding]; other site 83332005285 subunit interaction site [polypeptide binding]; other site 83332005286 PHB binding site; other site 83332005287 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 83332005288 alpha-gamma subunit interface [polypeptide binding]; other site 83332005289 beta-gamma subunit interface [polypeptide binding]; other site 83332005290 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 83332005291 gamma-beta subunit interface [polypeptide binding]; other site 83332005292 alpha-beta subunit interface [polypeptide binding]; other site 83332005293 urease subunit alpha; Reviewed; Region: ureC; PRK13206 83332005294 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 83332005295 subunit interactions [polypeptide binding]; other site 83332005296 active site 83332005297 flap region; other site 83332005298 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 83332005299 UreF; Region: UreF; pfam01730 83332005300 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 83332005301 UreD urease accessory protein; Region: UreD; cl00530 83332005302 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 83332005303 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 83332005304 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 83332005305 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 83332005306 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 83332005307 classical (c) SDRs; Region: SDR_c; cd05233 83332005308 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 83332005309 NAD(P) binding site [chemical binding]; other site 83332005310 active site 83332005311 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 83332005312 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 83332005313 sulfate transport protein; Provisional; Region: cysT; CHL00187 83332005314 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 83332005315 dimer interface [polypeptide binding]; other site 83332005316 conserved gate region; other site 83332005317 putative PBP binding loops; other site 83332005318 ABC-ATPase subunit interface; other site 83332005319 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 83332005320 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 83332005321 Walker A/P-loop; other site 83332005322 ATP binding site [chemical binding]; other site 83332005323 Q-loop/lid; other site 83332005324 ABC transporter signature motif; other site 83332005325 Walker B; other site 83332005326 D-loop; other site 83332005327 H-loop/switch region; other site 83332005328 TOBE domain; Region: TOBE; pfam03459 83332005329 Fibronectin-attachment protein (FAP); Region: FAP; pfam07174 83332005330 Predicted membrane protein [Function unknown]; Region: COG2261 83332005331 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 83332005332 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 83332005333 putative NAD(P) binding site [chemical binding]; other site 83332005334 putative substrate binding site [chemical binding]; other site 83332005335 catalytic Zn binding site [ion binding]; other site 83332005336 structural Zn binding site [ion binding]; other site 83332005337 CAAX protease self-immunity; Region: Abi; pfam02517 83332005338 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 83332005339 MOSC domain; Region: MOSC; pfam03473 83332005340 short chain dehydrogenase; Provisional; Region: PRK07825 83332005341 classical (c) SDRs; Region: SDR_c; cd05233 83332005342 NAD(P) binding site [chemical binding]; other site 83332005343 active site 83332005344 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 83332005345 CoA-transferase family III; Region: CoA_transf_3; pfam02515 83332005346 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 83332005347 CoA-transferase family III; Region: CoA_transf_3; pfam02515 83332005348 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 83332005349 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 83332005350 active site 83332005351 hypothetical protein; Provisional; Region: PRK12320 83332005352 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 83332005353 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 83332005354 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 83332005355 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 83332005356 Domain of unknown function (DUF385); Region: DUF385; pfam04075 83332005357 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 83332005358 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 83332005359 active site 83332005360 substrate binding site [chemical binding]; other site 83332005361 FMN binding site [chemical binding]; other site 83332005362 putative catalytic residues [active] 83332005363 Uncharacterized conserved protein [Function unknown]; Region: COG5579 83332005364 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 83332005365 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 83332005366 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 83332005367 heme binding site [chemical binding]; other site 83332005368 ferroxidase pore; other site 83332005369 ferroxidase diiron center [ion binding]; other site 83332005370 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 83332005371 Major Facilitator Superfamily; Region: MFS_1; pfam07690 83332005372 putative substrate translocation pore; other site 83332005373 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 83332005374 putative substrate translocation pore; other site 83332005375 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cl00333 83332005376 23S rRNA interface [nucleotide binding]; other site 83332005377 L3 interface [polypeptide binding]; other site 83332005378 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 83332005379 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 83332005380 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 83332005381 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 83332005382 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 83332005383 Cytochrome P450; Region: p450; cl12078 83332005384 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 83332005385 short chain dehydrogenase; Provisional; Region: PRK08267 83332005386 classical (c) SDR, subgroup 9; Region: SDR_c9; cd08931 83332005387 putative NAD(P) binding site [chemical binding]; other site 83332005388 active site 83332005389 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 83332005390 hydrophobic ligand binding site; other site 83332005391 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 83332005392 chorismate mutase; Provisional; Region: PRK09269 83332005393 chorismate mutase, putative; Region: CM_mono2; TIGR01806 83332005394 Putative esterase; Region: Esterase; pfam00756 83332005395 Leucine carboxyl methyltransferase; Region: LCM; cl01306 83332005396 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 83332005397 Leucine carboxyl methyltransferase; Region: LCM; cl01306 83332005398 Uncharacterized conserved protein [Function unknown]; Region: COG2353 83332005399 Nitronate monooxygenase; Region: NMO; pfam03060 83332005400 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 83332005401 FMN binding site [chemical binding]; other site 83332005402 substrate binding site [chemical binding]; other site 83332005403 putative catalytic residue [active] 83332005404 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 2; Region: FDH_like_2; cd08284 83332005405 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 83332005406 catalytic Zn binding site [ion binding]; other site 83332005407 NAD(P) binding site [chemical binding]; other site 83332005408 structural Zn binding site [ion binding]; other site 83332005409 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 83332005410 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 83332005411 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 83332005412 putative active site [active] 83332005413 dimerization interface [polypeptide binding]; other site 83332005414 putative tRNAtyr binding site [nucleotide binding]; other site 83332005415 Domain of unknown function DUF77; Region: DUF77; pfam01910 83332005416 Macro domain, Unknown family 2. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_2; cd03330 83332005417 putative ADP-ribose binding site [chemical binding]; other site 83332005418 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 83332005419 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 83332005420 cyclase homology domain; Region: CHD; cd07302 83332005421 nucleotidyl binding site; other site 83332005422 metal binding site [ion binding]; metal-binding site 83332005423 dimer interface [polypeptide binding]; other site 83332005424 competence damage-inducible protein A; Provisional; Region: PRK00549 83332005425 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 83332005426 putative MPT binding site; other site 83332005427 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 83332005428 putative sialic acid transporter; Region: 2A0112; TIGR00891 83332005429 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 83332005430 putative substrate translocation pore; other site 83332005431 Predicted membrane protein [Function unknown]; Region: COG1950 83332005432 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 83332005433 anti sigma factor interaction site; other site 83332005434 regulatory phosphorylation site [posttranslational modification]; other site 83332005435 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 83332005436 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 83332005437 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 83332005438 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 83332005439 dimer interface [polypeptide binding]; other site 83332005440 active site 83332005441 heme binding site [chemical binding]; other site 83332005442 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 83332005443 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 83332005444 metal binding site 2 [ion binding]; metal-binding site 83332005445 putative DNA binding helix; other site 83332005446 metal binding site 1 [ion binding]; metal-binding site 83332005447 dimer interface [polypeptide binding]; other site 83332005448 structural Zn2+ binding site [ion binding]; other site 83332005449 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 83332005450 substrate binding site [chemical binding]; other site 83332005451 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 83332005452 substrate binding site [chemical binding]; other site 83332005453 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 83332005454 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR3; cd08275 83332005455 putative NAD(P) binding site [chemical binding]; other site 83332005456 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 83332005457 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 83332005458 tetramer interface [polypeptide binding]; other site 83332005459 active site 83332005460 Mg2+/Mn2+ binding site [ion binding]; other site 83332005461 Isocitrate lyase [Energy production and conversion]; Region: AceA; COG2224 83332005462 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332005463 PPE family; Region: PPE; pfam00823 83332005464 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332005465 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332005466 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332005467 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332005468 PPE family; Region: PPE; pfam00823 83332005469 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332005470 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332005471 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 83332005472 putative hydrophobic ligand binding site [chemical binding]; other site 83332005473 protein interface [polypeptide binding]; other site 83332005474 gate; other site 83332005475 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 83332005476 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 83332005477 putative acyl-acceptor binding pocket; other site 83332005478 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 83332005479 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 83332005480 Beta-lactamase; Region: Beta-lactamase; pfam00144 83332005481 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 83332005482 Beta-lactamase; Region: Beta-lactamase; pfam00144 83332005483 putative fatty-acid--CoA ligase; Provisional; Region: PRK12476 83332005484 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 83332005485 acyl-activating enzyme (AAE) consensus motif; other site 83332005486 active site 83332005487 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 83332005488 Uncharacterized conserved protein [Function unknown]; Region: COG3361 83332005489 short chain dehydrogenase; Provisional; Region: PRK05867 83332005490 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 83332005491 NAD(P) binding site [chemical binding]; other site 83332005492 active site 83332005493 TIGR03085 family protein; Region: TIGR03085 83332005494 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 83332005495 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 83332005496 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 83332005497 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 83332005498 conserved cys residue [active] 83332005499 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 83332005500 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 83332005501 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 83332005502 dimer interface [polypeptide binding]; other site 83332005503 catalytic triad [active] 83332005504 peroxidatic and resolving cysteines [active] 83332005505 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332005506 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 83332005507 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 83332005508 active site 83332005509 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332005510 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 83332005511 FAD binding site [chemical binding]; other site 83332005512 substrate binding site [chemical binding]; other site 83332005513 catalytic base [active] 83332005514 enoyl-CoA hydratase; Provisional; Region: PRK08290 83332005515 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 83332005516 substrate binding site [chemical binding]; other site 83332005517 oxyanion hole (OAH) forming residues; other site 83332005518 trimer interface [polypeptide binding]; other site 83332005519 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 83332005520 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 83332005521 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 83332005522 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 83332005523 catalytic loop [active] 83332005524 iron binding site [ion binding]; other site 83332005525 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 83332005526 FAD binding pocket [chemical binding]; other site 83332005527 FAD binding motif [chemical binding]; other site 83332005528 phosphate binding motif [ion binding]; other site 83332005529 beta-alpha-beta structure motif; other site 83332005530 NAD binding pocket [chemical binding]; other site 83332005531 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 83332005532 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 83332005533 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 83332005534 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 83332005535 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 83332005536 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 83332005537 dimerization interface [polypeptide binding]; other site 83332005538 active site 83332005539 classical (c) SDR, subgroup 12; Region: SDR_c12; cd08944 83332005540 putative NAD(P) binding site [chemical binding]; other site 83332005541 active site 83332005542 homodimer interface [polypeptide binding]; other site 83332005543 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 83332005544 SEC-C motif; Region: SEC-C; pfam02810 83332005545 Domain of unknown function (DUF222); Region: DUF222; pfam02720 83332005546 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 83332005547 active site 83332005548 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 83332005549 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487 83332005550 YjzC-like protein; Region: YjzC; pfam14168 83332005551 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 83332005552 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 83332005553 non-specific DNA binding site [nucleotide binding]; other site 83332005554 salt bridge; other site 83332005555 sequence-specific DNA binding site [nucleotide binding]; other site 83332005556 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 83332005557 Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693 83332005558 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 83332005559 putative active site [active] 83332005560 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 83332005561 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332005562 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332005563 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332005564 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332005565 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 83332005566 Permease; Region: Permease; pfam02405 83332005567 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 83332005568 Permease; Region: Permease; pfam02405 83332005569 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 83332005570 mce related protein; Region: MCE; pfam02470 83332005571 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 83332005572 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 83332005573 mce related protein; Region: MCE; pfam02470 83332005574 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 83332005575 mce related protein; Region: MCE; pfam02470 83332005576 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 83332005577 mce related protein; Region: MCE; pfam02470 83332005578 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 83332005579 mce related protein; Region: MCE; pfam02470 83332005580 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 83332005581 mce related protein; Region: MCE; pfam02470 83332005582 Protein of unknown function (DUF732); Region: DUF732; pfam05305 83332005583 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 83332005584 YacP-like NYN domain; Region: NYN_YacP; cl01491 83332005585 Peptidase family M48; Region: Peptidase_M48; pfam01435 83332005586 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332005587 S-adenosylmethionine binding site [chemical binding]; other site 83332005588 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 83332005589 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 83332005590 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 83332005591 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 83332005592 dimer interface [polypeptide binding]; other site 83332005593 putative radical transfer pathway; other site 83332005594 diiron center [ion binding]; other site 83332005595 tyrosyl radical; other site 83332005596 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 83332005597 putative active site [active] 83332005598 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 83332005599 PE family; Region: PE; pfam00934 83332005600 Cutinase; Region: Cutinase; pfam01083 83332005601 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 83332005602 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 83332005603 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 83332005604 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 83332005605 dimerization interface [polypeptide binding]; other site 83332005606 Lysine efflux permease [General function prediction only]; Region: COG1279 83332005607 Cellulose binding domain; Region: CBM_2; pfam00553 83332005608 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332005609 S-adenosylmethionine binding site [chemical binding]; other site 83332005610 Uncharacterized conserved protein [Function unknown]; Region: COG5654 83332005611 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 83332005612 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 83332005613 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 83332005614 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 83332005615 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 83332005616 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 83332005617 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 83332005618 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 83332005619 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 83332005620 dimerization interface [polypeptide binding]; other site 83332005621 putative DNA binding site [nucleotide binding]; other site 83332005622 putative Zn2+ binding site [ion binding]; other site 83332005623 Hemerythrin-like domain; Region: Hr-like; cd12108 83332005624 Fe binding site [ion binding]; other site 83332005625 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 83332005626 Ligand Binding Site [chemical binding]; other site 83332005627 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 83332005628 Ligand Binding Site [chemical binding]; other site 83332005629 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 83332005630 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 83332005631 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 83332005632 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 83332005633 Soluble P-type ATPase [General function prediction only]; Region: COG4087 83332005634 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 83332005635 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 83332005636 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 83332005637 tetramer interface [polypeptide binding]; other site 83332005638 active site 83332005639 Mg2+/Mn2+ binding site [ion binding]; other site 83332005640 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 83332005641 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 83332005642 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 83332005643 3beta17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 3beta-17beta-HSD_like_SDR_c; cd05341 83332005644 homotetramer interface [polypeptide binding]; other site 83332005645 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 83332005646 NAD binding site [chemical binding]; other site 83332005647 homodimer interface [polypeptide binding]; other site 83332005648 active site 83332005649 Methyltransferase domain; Region: Methyltransf_23; pfam13489 83332005650 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332005651 S-adenosylmethionine binding site [chemical binding]; other site 83332005652 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 83332005653 Predicted kinase [General function prediction only]; Region: COG0645 83332005654 AAA domain; Region: AAA_17; pfam13207 83332005655 Universal stress protein family; Region: Usp; pfam00582 83332005656 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 83332005657 Ligand Binding Site [chemical binding]; other site 83332005658 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 83332005659 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 83332005660 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 83332005661 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 83332005662 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 83332005663 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 83332005664 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 83332005665 Ferredoxin [Energy production and conversion]; Region: COG1146 83332005666 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 83332005667 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 83332005668 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 83332005669 Walker A motif; other site 83332005670 ATP binding site [chemical binding]; other site 83332005671 Walker B motif; other site 83332005672 arginine finger; other site 83332005673 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 83332005674 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 83332005675 putative active site [active] 83332005676 Transcriptional regulators [Transcription]; Region: MarR; COG1846 83332005677 MarR family; Region: MarR_2; pfam12802 83332005678 Phage envelope protein [General function prediction only]; Region: COG5562 83332005679 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 83332005680 Transposase; Region: DEDD_Tnp_IS110; pfam01548 83332005681 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 83332005682 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 83332005683 Domain of unknown function (DUF222); Region: DUF222; pfam02720 83332005684 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 83332005685 active site 83332005686 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 83332005687 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 83332005688 non-specific DNA binding site [nucleotide binding]; other site 83332005689 salt bridge; other site 83332005690 sequence-specific DNA binding site [nucleotide binding]; other site 83332005691 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 83332005692 Uncharacterized conserved protein [Function unknown]; Region: COG2442 83332005693 Predicted helicase [General function prediction only]; Region: COG4889 83332005694 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 83332005695 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 83332005696 non-specific DNA binding site [nucleotide binding]; other site 83332005697 salt bridge; other site 83332005698 sequence-specific DNA binding site [nucleotide binding]; other site 83332005699 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4683 83332005700 Restriction endonuclease; Region: Mrr_cat_2; pfam13156 83332005701 DEAD-like helicases superfamily; Region: DEXDc; smart00487 83332005702 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 83332005703 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 83332005704 ATP binding site [chemical binding]; other site 83332005705 putative Mg++ binding site [ion binding]; other site 83332005706 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 83332005707 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 83332005708 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 83332005709 Ligand Binding Site [chemical binding]; other site 83332005710 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 83332005711 Ligand Binding Site [chemical binding]; other site 83332005712 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 83332005713 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 83332005714 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 83332005715 Histidine kinase; Region: HisKA_3; pfam07730 83332005716 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 83332005717 Ligand Binding Site [chemical binding]; other site 83332005718 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 83332005719 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 83332005720 putative substrate binding site [chemical binding]; other site 83332005721 putative ATP binding site [chemical binding]; other site 83332005722 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 83332005723 active site 83332005724 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 83332005725 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 83332005726 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 83332005727 putative dimer interface [polypeptide binding]; other site 83332005728 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 83332005729 dimer interface [polypeptide binding]; other site 83332005730 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 83332005731 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 83332005732 putative DNA binding site [nucleotide binding]; other site 83332005733 dimerization interface [polypeptide binding]; other site 83332005734 putative Zn2+ binding site [ion binding]; other site 83332005735 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 83332005736 putative hydrophobic ligand binding site [chemical binding]; other site 83332005737 CLM binding site; other site 83332005738 L1 loop; other site 83332005739 DNA binding site [nucleotide binding] 83332005740 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 83332005741 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 83332005742 MDMPI C-terminal domain; Region: MDMPI_C; pfam07398 83332005743 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 83332005744 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 83332005745 nucleophile elbow; other site 83332005746 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 83332005747 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 83332005748 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 83332005749 Walker A/P-loop; other site 83332005750 ATP binding site [chemical binding]; other site 83332005751 Q-loop/lid; other site 83332005752 ABC transporter signature motif; other site 83332005753 Walker B; other site 83332005754 D-loop; other site 83332005755 H-loop/switch region; other site 83332005756 TOBE domain; Region: TOBE_2; pfam08402 83332005757 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 83332005758 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 83332005759 dimer interface [polypeptide binding]; other site 83332005760 conserved gate region; other site 83332005761 putative PBP binding loops; other site 83332005762 ABC-ATPase subunit interface; other site 83332005763 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 83332005764 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 83332005765 dimer interface [polypeptide binding]; other site 83332005766 conserved gate region; other site 83332005767 putative PBP binding loops; other site 83332005768 ABC-ATPase subunit interface; other site 83332005769 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 83332005770 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 83332005771 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 83332005772 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 83332005773 Isochorismatase family; Region: Isochorismatase; pfam00857 83332005774 catalytic triad [active] 83332005775 metal binding site [ion binding]; metal-binding site 83332005776 conserved cis-peptide bond; other site 83332005777 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 83332005778 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 83332005779 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 83332005780 substrate binding pocket [chemical binding]; other site 83332005781 catalytic triad [active] 83332005782 hypothetical protein; Provisional; Region: PRK05865 83332005783 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 83332005784 NAD(P) binding site [chemical binding]; other site 83332005785 active site 83332005786 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 83332005787 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 83332005788 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 83332005789 active site 83332005790 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 83332005791 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 83332005792 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 83332005793 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 83332005794 Enoylreductase; Region: PKS_ER; smart00829 83332005795 NAD(P) binding site [chemical binding]; other site 83332005796 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 83332005797 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 83332005798 putative NADP binding site [chemical binding]; other site 83332005799 active site 83332005800 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 83332005801 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 83332005802 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 83332005803 active site 83332005804 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 83332005805 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 83332005806 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 83332005807 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 83332005808 Enoylreductase; Region: PKS_ER; smart00829 83332005809 NAD(P) binding site [chemical binding]; other site 83332005810 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 83332005811 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 83332005812 putative NADP binding site [chemical binding]; other site 83332005813 active site 83332005814 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 83332005815 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 83332005816 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 83332005817 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 83332005818 putative active site [active] 83332005819 catalytic triad [active] 83332005820 putative dimer interface [polypeptide binding]; other site 83332005821 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 83332005822 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 83332005823 Ligand binding site; other site 83332005824 Putative Catalytic site; other site 83332005825 DXD motif; other site 83332005826 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 83332005827 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 83332005828 active site 83332005829 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 83332005830 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 83332005831 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 83332005832 30S ribosomal protein S18; Provisional; Region: PRK13401 83332005833 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 83332005834 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 83332005835 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 83332005836 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 83332005837 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 83332005838 intersubunit interface [polypeptide binding]; other site 83332005839 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 83332005840 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 83332005841 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 83332005842 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 83332005843 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 83332005844 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 83332005845 PemK-like protein; Region: PemK; pfam02452 83332005846 precorrin-3B synthase; Region: CobG; TIGR02435 83332005847 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 83332005848 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 83332005849 Precorrin-8X methylmutase; Region: CbiC; pfam02570 83332005850 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 83332005851 active site 83332005852 SAM binding site [chemical binding]; other site 83332005853 homodimer interface [polypeptide binding]; other site 83332005854 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 83332005855 active site 83332005856 SAM binding site [chemical binding]; other site 83332005857 homodimer interface [polypeptide binding]; other site 83332005858 Methyltransferase domain; Region: Methyltransf_31; pfam13847 83332005859 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332005860 S-adenosylmethionine binding site [chemical binding]; other site 83332005861 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 83332005862 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 83332005863 RNA polymerase sigma factor SigC; Reviewed; Region: PRK09649 83332005864 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 83332005865 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 83332005866 DNA binding residues [nucleotide binding] 83332005867 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 83332005868 precorrin-6x reductase; Region: precor6x_red; TIGR00715 83332005869 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 83332005870 active site 83332005871 SAM binding site [chemical binding]; other site 83332005872 homodimer interface [polypeptide binding]; other site 83332005873 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 83332005874 active site 83332005875 putative homodimer interface [polypeptide binding]; other site 83332005876 SAM binding site [chemical binding]; other site 83332005877 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 83332005878 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 83332005879 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 83332005880 NAD(P) binding site [chemical binding]; other site 83332005881 active site 83332005882 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 83332005883 Catalytic domain of uncharacterized Mycobacterium tuberculosis Rv2075c-like proteins; Region: PI-PLCc_Rv2075c_like; cd08590 83332005884 putative active site [active] 83332005885 catalytic site [active] 83332005886 putative metal binding site [ion binding]; other site 83332005887 C-type lectin (CTL)/C-type lectin-like (CTLD) domain; Region: CLECT; cl02432 83332005888 Protein of unknown function (DUF2563); Region: DUF2563; pfam10817 83332005889 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 83332005890 putative transposase OrfB; Reviewed; Region: PHA02517 83332005891 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 83332005892 Catalytic domain of Protein Kinases; Region: PKc; cd00180 83332005893 active site 83332005894 ATP binding site [chemical binding]; other site 83332005895 substrate binding site [chemical binding]; other site 83332005896 activation loop (A-loop); other site 83332005897 PknH-like extracellular domain; Region: PknH_C; pfam14032 83332005898 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 83332005899 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 83332005900 active site 83332005901 5'-3' exonuclease; Region: 53EXOc; smart00475 83332005902 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 83332005903 active site 83332005904 metal binding site 1 [ion binding]; metal-binding site 83332005905 putative 5' ssDNA interaction site; other site 83332005906 metal binding site 3; metal-binding site 83332005907 metal binding site 2 [ion binding]; metal-binding site 83332005908 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 83332005909 putative DNA binding site [nucleotide binding]; other site 83332005910 putative metal binding site [ion binding]; other site 83332005911 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 83332005912 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 83332005913 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 83332005914 ATP binding site [chemical binding]; other site 83332005915 putative Mg++ binding site [ion binding]; other site 83332005916 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 83332005917 nucleotide binding region [chemical binding]; other site 83332005918 ATP-binding site [chemical binding]; other site 83332005919 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 83332005920 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 83332005921 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 83332005922 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 83332005923 Predicted transcriptional regulator [Transcription]; Region: COG2378 83332005924 WYL domain; Region: WYL; pfam13280 83332005925 Predicted transcriptional regulator [Transcription]; Region: COG2378 83332005926 WYL domain; Region: WYL; pfam13280 83332005927 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 83332005928 PE family; Region: PE; pfam00934 83332005929 Domain of unknown function (DUF222); Region: DUF222; pfam02720 83332005930 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 83332005931 active site 83332005932 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 83332005933 SNF2 Helicase protein; Region: DUF3670; pfam12419 83332005934 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 83332005935 ATP binding site [chemical binding]; other site 83332005936 putative Mg++ binding site [ion binding]; other site 83332005937 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 83332005938 nucleotide binding region [chemical binding]; other site 83332005939 ATP-binding site [chemical binding]; other site 83332005940 Uncharacterized conserved protein [Function unknown]; Region: COG4279 83332005941 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 83332005942 putative active site [active] 83332005943 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 83332005944 Transposase; Region: HTH_Tnp_1; cl17663 83332005945 putative transposase OrfB; Reviewed; Region: PHA02517 83332005946 HTH-like domain; Region: HTH_21; pfam13276 83332005947 Integrase core domain; Region: rve; pfam00665 83332005948 Integrase core domain; Region: rve_3; pfam13683 83332005949 PE family; Region: PE; pfam00934 83332005950 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332005951 PPE family; Region: PPE; pfam00823 83332005952 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 83332005953 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 83332005954 active site 83332005955 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 83332005956 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 83332005957 active site 83332005958 Pup-like protein; Region: Pup; pfam05639 83332005959 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 83332005960 proteasome ATPase; Region: pup_AAA; TIGR03689 83332005961 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 83332005962 Walker A motif; other site 83332005963 ATP binding site [chemical binding]; other site 83332005964 Walker B motif; other site 83332005965 arginine finger; other site 83332005966 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 83332005967 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550 83332005968 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 83332005969 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332005970 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 83332005971 Predicted membrane protein [Function unknown]; Region: COG3918 83332005972 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 83332005973 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 83332005974 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 83332005975 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 83332005976 homodimer interface [polypeptide binding]; other site 83332005977 putative metal binding site [ion binding]; other site 83332005978 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332005979 PPE family; Region: PPE; pfam00823 83332005980 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 83332005981 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 83332005982 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 83332005983 substrate binding pocket [chemical binding]; other site 83332005984 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 83332005985 B12 binding site [chemical binding]; other site 83332005986 cobalt ligand [ion binding]; other site 83332005987 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 83332005988 PAC2 family; Region: PAC2; pfam09754 83332005989 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 83332005990 short chain dehydrogenase; Provisional; Region: PRK05872 83332005991 classical (c) SDRs; Region: SDR_c; cd05233 83332005992 NAD(P) binding site [chemical binding]; other site 83332005993 active site 83332005994 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 83332005995 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 83332005996 active site 83332005997 HIGH motif; other site 83332005998 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 83332005999 active site 83332006000 KMSKS motif; other site 83332006001 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 83332006002 putative tRNA binding surface [nucleotide binding]; other site 83332006003 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 83332006004 active site 83332006005 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 83332006006 conserved hypothetical protein; Region: TIGR03843 83332006007 conserved hypothetical protein; Region: TIGR03847 83332006008 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 83332006009 catalytic core [active] 83332006010 undecaprenyl-diphosphatase UppP; Region: undec_PP_bacA; TIGR00753 83332006011 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 83332006012 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 83332006013 quinone interaction residues [chemical binding]; other site 83332006014 active site 83332006015 catalytic residues [active] 83332006016 FMN binding site [chemical binding]; other site 83332006017 substrate binding site [chemical binding]; other site 83332006018 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 83332006019 substrate binding site [chemical binding]; other site 83332006020 hypothetical protein; Provisional; Region: PRK07906 83332006021 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 83332006022 putative metal binding site [ion binding]; other site 83332006023 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 83332006024 putative addiction module component, TIGR02574 family; Region: stabl_TIGR02574 83332006025 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 83332006026 active site 83332006027 DivIVA domain; Region: DivI1A_domain; TIGR03544 83332006028 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 83332006029 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 83332006030 Predicted integral membrane protein [Function unknown]; Region: COG0762 83332006031 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 83332006032 Predicted enzyme with a TIM-barrel fold [General function prediction only]; Region: COG0325 83332006033 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 83332006034 catalytic residue [active] 83332006035 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 83332006036 uncharacterized protein, YfiH family; Region: TIGR00726 83332006037 cell division protein FtsZ; Validated; Region: PRK09330 83332006038 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 83332006039 nucleotide binding site [chemical binding]; other site 83332006040 SulA interaction site; other site 83332006041 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 83332006042 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 83332006043 Cell division protein FtsQ; Region: FtsQ; pfam03799 83332006044 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 83332006045 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 83332006046 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 83332006047 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 83332006048 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 83332006049 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 83332006050 active site 83332006051 homodimer interface [polypeptide binding]; other site 83332006052 cell division protein FtsW; Region: ftsW; TIGR02614 83332006053 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369 83332006054 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 83332006055 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 83332006056 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 83332006057 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 83332006058 Mg++ binding site [ion binding]; other site 83332006059 putative catalytic motif [active] 83332006060 putative substrate binding site [chemical binding]; other site 83332006061 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 83332006062 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 83332006063 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 83332006064 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 83332006065 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 83332006066 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 83332006067 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 83332006068 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 83332006069 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 83332006070 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 83332006071 PE family; Region: PE; pfam00934 83332006072 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 83332006073 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 83332006074 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 83332006075 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 83332006076 MraW methylase family; Region: Methyltransf_5; pfam01795 83332006077 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 83332006078 MraZ protein; Region: MraZ; pfam02381 83332006079 MraZ protein; Region: MraZ; pfam02381 83332006080 putative transposase OrfB; Reviewed; Region: PHA02517 83332006081 HTH-like domain; Region: HTH_21; pfam13276 83332006082 Integrase core domain; Region: rve; pfam00665 83332006083 Integrase core domain; Region: rve_3; pfam13683 83332006084 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 83332006085 Transposase; Region: HTH_Tnp_1; cl17663 83332006086 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 83332006087 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 83332006088 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 83332006089 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 83332006090 substrate binding pocket [chemical binding]; other site 83332006091 chain length determination region; other site 83332006092 substrate-Mg2+ binding site; other site 83332006093 catalytic residues [active] 83332006094 aspartate-rich region 1; other site 83332006095 active site lid residues [active] 83332006096 aspartate-rich region 2; other site 83332006097 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 83332006098 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 83332006099 Catalytic domain of Protein Kinases; Region: PKc; cd00180 83332006100 active site 83332006101 ATP binding site [chemical binding]; other site 83332006102 substrate binding site [chemical binding]; other site 83332006103 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 83332006104 substrate binding site [chemical binding]; other site 83332006105 activation loop (A-loop); other site 83332006106 activation loop (A-loop); other site 83332006107 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 83332006108 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 83332006109 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG3200 83332006110 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 83332006111 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 83332006112 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 83332006113 putative acyl-acceptor binding pocket; other site 83332006114 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 83332006115 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 83332006116 DTAP/Switch II; other site 83332006117 Switch I; other site 83332006118 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 83332006119 putative hydrophobic ligand binding site [chemical binding]; other site 83332006120 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 83332006121 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 83332006122 acyl-activating enzyme (AAE) consensus motif; other site 83332006123 putative AMP binding site [chemical binding]; other site 83332006124 putative active site [active] 83332006125 putative CoA binding site [chemical binding]; other site 83332006126 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 83332006127 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 83332006128 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 83332006129 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 83332006130 NlpC/P60 family; Region: NLPC_P60; pfam00877 83332006131 hypothetical protein; Validated; Region: PRK07883 83332006132 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 83332006133 active site 83332006134 catalytic site [active] 83332006135 substrate binding site [chemical binding]; other site 83332006136 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 83332006137 GIY-YIG motif/motif A; other site 83332006138 active site 83332006139 catalytic site [active] 83332006140 putative DNA binding site [nucleotide binding]; other site 83332006141 metal binding site [ion binding]; metal-binding site 83332006142 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 83332006143 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 83332006144 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 83332006145 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 83332006146 Subunit I/III interface [polypeptide binding]; other site 83332006147 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 83332006148 Cytochrome c; Region: Cytochrom_C; pfam00034 83332006149 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 83332006150 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 83332006151 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 83332006152 iron-sulfur cluster [ion binding]; other site 83332006153 [2Fe-2S] cluster binding site [ion binding]; other site 83332006154 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 83332006155 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 83332006156 heme bH binding site [chemical binding]; other site 83332006157 intrachain domain interface; other site 83332006158 heme bL binding site [chemical binding]; other site 83332006159 interchain domain interface [polypeptide binding]; other site 83332006160 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 83332006161 Qo binding site; other site 83332006162 Protein of unknown function (DUF2561); Region: DUF2561; pfam10812 83332006163 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 83332006164 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 83332006165 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 83332006166 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 83332006167 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 83332006168 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 83332006169 dimer interface [polypeptide binding]; other site 83332006170 active site 83332006171 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 83332006172 Ligand Binding Site [chemical binding]; other site 83332006173 Molecular Tunnel; other site 83332006174 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 83332006175 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 83332006176 substrate binding site [chemical binding]; other site 83332006177 ATP binding site [chemical binding]; other site 83332006178 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 83332006179 Glycerate kinase family; Region: Gly_kinase; pfam02595 83332006180 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 83332006181 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 83332006182 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 83332006183 putative dimer interface [polypeptide binding]; other site 83332006184 active site pocket [active] 83332006185 putative cataytic base [active] 83332006186 Cobalamin-5-phosphate synthase; Region: CobS; pfam02654 83332006187 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 83332006188 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 83332006189 homodimer interface [polypeptide binding]; other site 83332006190 substrate-cofactor binding pocket; other site 83332006191 catalytic residue [active] 83332006192 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 83332006193 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 83332006194 cyclase homology domain; Region: CHD; cd07302 83332006195 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 83332006196 nucleotidyl binding site; other site 83332006197 metal binding site [ion binding]; metal-binding site 83332006198 dimer interface [polypeptide binding]; other site 83332006199 multifunctional aminopeptidase A; Provisional; Region: PRK00913 83332006200 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 83332006201 interface (dimer of trimers) [polypeptide binding]; other site 83332006202 Substrate-binding/catalytic site; other site 83332006203 Zn-binding sites [ion binding]; other site 83332006204 short chain dehydrogenase; Validated; Region: PRK05855 83332006205 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 83332006206 classical (c) SDRs; Region: SDR_c; cd05233 83332006207 NAD(P) binding site [chemical binding]; other site 83332006208 active site 83332006209 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 83332006210 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 83332006211 E3 interaction surface; other site 83332006212 lipoyl attachment site [posttranslational modification]; other site 83332006213 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 83332006214 E3 interaction surface; other site 83332006215 lipoyl attachment site [posttranslational modification]; other site 83332006216 e3 binding domain; Region: E3_binding; pfam02817 83332006217 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 83332006218 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 83332006219 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 83332006220 putative NAD(P) binding site [chemical binding]; other site 83332006221 putative active site [active] 83332006222 lipoate-protein ligase B; Provisional; Region: PRK14345 83332006223 lipoyl synthase; Provisional; Region: PRK05481 83332006224 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 83332006225 FeS/SAM binding site; other site 83332006226 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 83332006227 RDD family; Region: RDD; pfam06271 83332006228 glutamine synthetase, type I; Region: GlnA; TIGR00653 83332006229 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 83332006230 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 83332006231 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 83332006232 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 83332006233 metal binding triad; other site 83332006234 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 83332006235 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 83332006236 metal binding triad; other site 83332006237 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 83332006238 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 83332006239 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 83332006240 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 83332006241 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 83332006242 TAP-like protein; Region: Abhydrolase_4; pfam08386 83332006243 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 83332006244 TAP-like protein; Region: Abhydrolase_4; pfam08386 83332006245 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 83332006246 oligomerization interface [polypeptide binding]; other site 83332006247 active site 83332006248 metal binding site [ion binding]; metal-binding site 83332006249 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 83332006250 putative active site; other site 83332006251 putative metal binding residues [ion binding]; other site 83332006252 signature motif; other site 83332006253 putative triphosphate binding site [ion binding]; other site 83332006254 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 83332006255 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3826 83332006256 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 83332006257 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 83332006258 RNA/DNA hybrid binding site [nucleotide binding]; other site 83332006259 active site 83332006260 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 83332006261 catalytic core [active] 83332006262 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 83332006263 Putative zinc ribbon domain; Region: DUF164; pfam02591 83332006264 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 83332006265 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 83332006266 Uncharacterized conserved protein [Function unknown]; Region: COG0327 83332006267 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 83332006268 hypothetical protein; Provisional; Region: PRK07908 83332006269 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 83332006270 pyridoxal 5'-phosphate binding site [chemical binding]; other site 83332006271 homodimer interface [polypeptide binding]; other site 83332006272 catalytic residue [active] 83332006273 PIN domain nuclease, a component of toxin-antitoxin system (PIN domain) [Signal transduction mechanisms]; Region: COG3744 83332006274 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 83332006275 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 83332006276 active site 83332006277 motif I; other site 83332006278 motif II; other site 83332006279 Low molecular weight phosphatase family; Region: LMWPc; cd00115 83332006280 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 83332006281 active site 83332006282 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 83332006283 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 83332006284 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 83332006285 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 83332006286 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 83332006287 dimer interface [polypeptide binding]; other site 83332006288 catalytic triad [active] 83332006289 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 83332006290 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 83332006291 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 83332006292 dimer interface [polypeptide binding]; other site 83332006293 TPP-binding site [chemical binding]; other site 83332006294 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 83332006295 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 83332006296 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 83332006297 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 83332006298 acyl carrier protein; Provisional; Region: acpP; PRK00982 83332006299 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 83332006300 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 83332006301 dimer interface [polypeptide binding]; other site 83332006302 active site 83332006303 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 83332006304 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 83332006305 dimer interface [polypeptide binding]; other site 83332006306 active site 83332006307 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 83332006308 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 83332006309 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 83332006310 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 83332006311 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 83332006312 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332006313 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332006314 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 83332006315 FAD binding domain; Region: FAD_binding_4; pfam01565 83332006316 diacylglycerol kinase; Reviewed; Region: PRK11914 83332006317 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 83332006318 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 83332006319 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 83332006320 Beta-lactamase; Region: Beta-lactamase; pfam00144 83332006321 Methyltransferase domain; Region: Methyltransf_31; pfam13847 83332006322 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332006323 S-adenosylmethionine binding site [chemical binding]; other site 83332006324 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 83332006325 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 83332006326 NAD binding site [chemical binding]; other site 83332006327 catalytic Zn binding site [ion binding]; other site 83332006328 substrate binding site [chemical binding]; other site 83332006329 structural Zn binding site [ion binding]; other site 83332006330 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 83332006331 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 83332006332 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 83332006333 active site 83332006334 dimer interface [polypeptide binding]; other site 83332006335 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 83332006336 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 83332006337 catalytic triad [active] 83332006338 short chain dehydrogenase; Provisional; Region: PRK05854 83332006339 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 83332006340 putative NAD(P) binding site [chemical binding]; other site 83332006341 active site 83332006342 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 83332006343 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 83332006344 nucleotide binding site [chemical binding]; other site 83332006345 Major Facilitator Superfamily; Region: MFS_1; pfam07690 83332006346 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 83332006347 Cytochrome P450; Region: p450; cl12078 83332006348 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 83332006349 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 83332006350 Cytochrome P450; Region: p450; cl12078 83332006351 Septum formation; Region: Septum_form; pfam13845 83332006352 Protein of unknown function (DUF2695); Region: DUF2695; pfam10905 83332006353 Predicted membrane protein [Function unknown]; Region: COG2149 83332006354 Domain of unknown function (DUF202); Region: DUF202; pfam02656 83332006355 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 83332006356 Cytochrome P450; Region: p450; cl12078 83332006357 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial protein Rv2277c and similar proteins; Region: GDPD_Rv2277c_like; cd08580 83332006358 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 83332006359 putative active site [active] 83332006360 catalytic site [active] 83332006361 putative metal binding site [ion binding]; other site 83332006362 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 83332006363 Transposase; Region: HTH_Tnp_1; cl17663 83332006364 putative transposase OrfB; Reviewed; Region: PHA02517 83332006365 HTH-like domain; Region: HTH_21; pfam13276 83332006366 Integrase core domain; Region: rve; pfam00665 83332006367 Integrase core domain; Region: rve_3; pfam13683 83332006368 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 83332006369 FAD binding domain; Region: FAD_binding_4; pfam01565 83332006370 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 83332006371 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 83332006372 Transcriptional regulator [Transcription]; Region: LysR; COG0583 83332006373 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 83332006374 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 83332006375 dimerization interface [polypeptide binding]; other site 83332006376 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 83332006377 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 83332006378 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 83332006379 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 83332006380 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 83332006381 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 83332006382 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 83332006383 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 83332006384 CDP-diacylglycerol pyrophosphatase [Lipid metabolism]; Region: Cdh; COG2134 83332006385 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 83332006386 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 83332006387 active site residue [active] 83332006388 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 83332006389 active site residue [active] 83332006390 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 83332006391 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 83332006392 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 83332006393 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 83332006394 pyridoxal 5'-phosphate binding site [chemical binding]; other site 83332006395 homodimer interface [polypeptide binding]; other site 83332006396 catalytic residue [active] 83332006397 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3196 83332006398 haloalkane dehalogenase; Provisional; Region: PRK00870 83332006399 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 83332006400 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 83332006401 active site 83332006402 catalytic tetrad [active] 83332006403 heat shock protein 90; Provisional; Region: PRK05218 83332006404 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 83332006405 ATP binding site [chemical binding]; other site 83332006406 Mg2+ binding site [ion binding]; other site 83332006407 G-X-G motif; other site 83332006408 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 83332006409 Cutinase; Region: Cutinase; pfam01083 83332006410 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 83332006411 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 83332006412 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 83332006413 Uncharacterized conserved protein [Function unknown]; Region: COG0398 83332006414 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 83332006415 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 83332006416 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 83332006417 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 83332006418 Uncharacterized conserved protein [Function unknown]; Region: COG2442 83332006419 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 83332006420 DNA binding site [nucleotide binding] 83332006421 active site 83332006422 Int/Topo IB signature motif; other site 83332006423 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 83332006424 DNA binding residues [nucleotide binding] 83332006425 Family description; Region: UvrD_C_2; pfam13538 83332006426 Uncharacterized conserved protein [Function unknown]; Region: COG2128 83332006427 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 83332006428 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 83332006429 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 83332006430 putative PBP binding loops; other site 83332006431 ABC-ATPase subunit interface; other site 83332006432 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 83332006433 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 83332006434 dimer interface [polypeptide binding]; other site 83332006435 conserved gate region; other site 83332006436 putative PBP binding loops; other site 83332006437 ABC-ATPase subunit interface; other site 83332006438 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 83332006439 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 83332006440 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 83332006441 Ligand Binding Site [chemical binding]; other site 83332006442 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 83332006443 Ligand Binding Site [chemical binding]; other site 83332006444 amino acid transporter; Region: 2A0306; TIGR00909 83332006445 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 83332006446 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 83332006447 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 83332006448 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 83332006449 catalytic residue [active] 83332006450 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 83332006451 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 83332006452 Amidinotransferase; Region: Amidinotransf; pfam02274 83332006453 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 83332006454 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 83332006455 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 83332006456 putative DNA binding site [nucleotide binding]; other site 83332006457 putative Zn2+ binding site [ion binding]; other site 83332006458 AsnC family; Region: AsnC_trans_reg; pfam01037 83332006459 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 83332006460 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 83332006461 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 83332006462 Walker A/P-loop; other site 83332006463 ATP binding site [chemical binding]; other site 83332006464 Q-loop/lid; other site 83332006465 ABC transporter signature motif; other site 83332006466 Walker B; other site 83332006467 D-loop; other site 83332006468 H-loop/switch region; other site 83332006469 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 83332006470 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 83332006471 Walker A/P-loop; other site 83332006472 ATP binding site [chemical binding]; other site 83332006473 Q-loop/lid; other site 83332006474 ABC transporter signature motif; other site 83332006475 Walker B; other site 83332006476 D-loop; other site 83332006477 H-loop/switch region; other site 83332006478 MarR family; Region: MarR; pfam01047 83332006479 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 83332006480 PE family; Region: PE; pfam00934 83332006481 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 83332006482 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 83332006483 putative substrate translocation pore; other site 83332006484 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 83332006485 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 83332006486 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 83332006487 malate dehydrogenase; Provisional; Region: PRK13529 83332006488 Malic enzyme, N-terminal domain; Region: malic; pfam00390 83332006489 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 83332006490 NAD(P) binding site [chemical binding]; other site 83332006491 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 83332006492 Major Facilitator Superfamily; Region: MFS_1; pfam07690 83332006493 putative substrate translocation pore; other site 83332006494 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 83332006495 putative substrate translocation pore; other site 83332006496 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 83332006497 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 83332006498 dimer interface [polypeptide binding]; other site 83332006499 pyridoxal 5'-phosphate binding site [chemical binding]; other site 83332006500 catalytic residue [active] 83332006501 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 83332006502 serine O-acetyltransferase; Region: cysE; TIGR01172 83332006503 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 83332006504 trimer interface [polypeptide binding]; other site 83332006505 active site 83332006506 substrate binding site [chemical binding]; other site 83332006507 CoA binding site [chemical binding]; other site 83332006508 hypothetical protein; Provisional; Region: PRK14851 83332006509 hypothetical protein; Validated; Region: PRK08223 83332006510 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 83332006511 ATP binding site [chemical binding]; other site 83332006512 substrate interface [chemical binding]; other site 83332006513 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 83332006514 PE family; Region: PE; pfam00934 83332006515 DNA primase; Validated; Region: dnaG; PRK05667 83332006516 CHC2 zinc finger; Region: zf-CHC2; pfam01807 83332006517 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 83332006518 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 83332006519 active site 83332006520 metal binding site [ion binding]; metal-binding site 83332006521 interdomain interaction site; other site 83332006522 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 83332006523 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 83332006524 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 83332006525 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 83332006526 Zn2+ binding site [ion binding]; other site 83332006527 Mg2+ binding site [ion binding]; other site 83332006528 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 83332006529 Repair protein; Region: Repair_PSII; pfam04536 83332006530 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 83332006531 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 83332006532 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 83332006533 Phosphoesterase family; Region: Phosphoesterase; pfam04185 83332006534 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 83332006535 Phosphoesterase family; Region: Phosphoesterase; pfam04185 83332006536 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 83332006537 Phosphoesterase family; Region: Phosphoesterase; pfam04185 83332006538 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332006539 PPE family; Region: PPE; pfam00823 83332006540 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 83332006541 Transposase; Region: HTH_Tnp_1; cl17663 83332006542 putative transposase OrfB; Reviewed; Region: PHA02517 83332006543 HTH-like domain; Region: HTH_21; pfam13276 83332006544 Integrase core domain; Region: rve; pfam00665 83332006545 Integrase core domain; Region: rve_3; pfam13683 83332006546 PPE family; Region: PPE; pfam00823 83332006547 PPE family; Region: PPE; pfam00823 83332006548 glycyl-tRNA synthetase; Provisional; Region: PRK04173 83332006549 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 83332006550 motif 1; other site 83332006551 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 83332006552 active site 83332006553 motif 2; other site 83332006554 motif 3; other site 83332006555 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 83332006556 anticodon binding site; other site 83332006557 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 83332006558 dimerization interface [polypeptide binding]; other site 83332006559 putative DNA binding site [nucleotide binding]; other site 83332006560 putative Zn2+ binding site [ion binding]; other site 83332006561 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 83332006562 metal binding site 2 [ion binding]; metal-binding site 83332006563 putative DNA binding helix; other site 83332006564 metal binding site 1 [ion binding]; metal-binding site 83332006565 dimer interface [polypeptide binding]; other site 83332006566 structural Zn2+ binding site [ion binding]; other site 83332006567 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 83332006568 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 83332006569 catalytic residue [active] 83332006570 putative FPP diphosphate binding site; other site 83332006571 putative FPP binding hydrophobic cleft; other site 83332006572 dimer interface [polypeptide binding]; other site 83332006573 putative IPP diphosphate binding site; other site 83332006574 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 83332006575 Recombination protein O N terminal; Region: RecO_N; pfam11967 83332006576 Recombination protein O C terminal; Region: RecO_C; pfam02565 83332006577 amidase; Provisional; Region: PRK06061 83332006578 Amidase; Region: Amidase; pfam01425 83332006579 GTPase Era; Reviewed; Region: era; PRK00089 83332006580 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 83332006581 G1 box; other site 83332006582 GTP/Mg2+ binding site [chemical binding]; other site 83332006583 Switch I region; other site 83332006584 G2 box; other site 83332006585 Switch II region; other site 83332006586 G3 box; other site 83332006587 G4 box; other site 83332006588 G5 box; other site 83332006589 KH domain; Region: KH_2; pfam07650 83332006590 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 83332006591 Domain of unknown function DUF21; Region: DUF21; pfam01595 83332006592 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 83332006593 Transporter associated domain; Region: CorC_HlyC; smart01091 83332006594 metal-binding heat shock protein; Provisional; Region: PRK00016 83332006595 K homology RNA-binding domain; Region: KH; smart00322 83332006596 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 83332006597 PhoH-like protein; Region: PhoH; pfam02562 83332006598 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 83332006599 PE family; Region: PE; pfam00934 83332006600 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 83332006601 RNA methyltransferase, RsmE family; Region: TIGR00046 83332006602 chaperone protein DnaJ; Provisional; Region: PRK14278 83332006603 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 83332006604 HSP70 interaction site [polypeptide binding]; other site 83332006605 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 83332006606 Zn binding sites [ion binding]; other site 83332006607 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 83332006608 dimer interface [polypeptide binding]; other site 83332006609 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 83332006610 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 83332006611 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 83332006612 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 83332006613 Condensation domain; Region: Condensation; pfam00668 83332006614 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 83332006615 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 83332006616 acyl-activating enzyme (AAE) consensus motif; other site 83332006617 AMP binding site [chemical binding]; other site 83332006618 Condensation domain; Region: Condensation; pfam00668 83332006619 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 83332006620 Condensation domain; Region: Condensation; pfam00668 83332006621 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 83332006622 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 83332006623 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 83332006624 acyl-activating enzyme (AAE) consensus motif; other site 83332006625 AMP binding site [chemical binding]; other site 83332006626 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 83332006627 Condensation domain; Region: Condensation; pfam00668 83332006628 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 83332006629 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 83332006630 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 83332006631 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 83332006632 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 83332006633 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 83332006634 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 83332006635 NADP binding site [chemical binding]; other site 83332006636 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 83332006637 active site 83332006638 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 83332006639 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 83332006640 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 83332006641 active site 83332006642 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 83332006643 Condensation domain; Region: Condensation; pfam00668 83332006644 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 83332006645 Nonribosomal peptide synthase; Region: NRPS; pfam08415 83332006646 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 83332006647 acyl-activating enzyme (AAE) consensus motif; other site 83332006648 AMP binding site [chemical binding]; other site 83332006649 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 83332006650 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 83332006651 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 83332006652 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 83332006653 acyl-activating enzyme (AAE) consensus motif; other site 83332006654 active site 83332006655 AMP binding site [chemical binding]; other site 83332006656 substrate binding site [chemical binding]; other site 83332006657 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 83332006658 salicylate synthase MbtI; Reviewed; Region: PRK07912 83332006659 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 83332006660 Predicted permease [General function prediction only]; Region: COG3329 83332006661 coproporphyrinogen III oxidase; Validated; Region: PRK05628 83332006662 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 83332006663 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 83332006664 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 83332006665 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 83332006666 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 83332006667 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 83332006668 Active Sites [active] 83332006669 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 83332006670 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 83332006671 putative active site [active] 83332006672 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 83332006673 putative active site [active] 83332006674 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 83332006675 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 83332006676 Predicted membrane protein [Function unknown]; Region: COG1297 83332006677 putative oligopeptide transporter, OPT family; Region: TIGR00733 83332006678 PE family; Region: PE; pfam00934 83332006679 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 83332006680 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 83332006681 Walker A/P-loop; other site 83332006682 ATP binding site [chemical binding]; other site 83332006683 Q-loop/lid; other site 83332006684 ABC transporter signature motif; other site 83332006685 Walker B; other site 83332006686 D-loop; other site 83332006687 H-loop/switch region; other site 83332006688 sulfate transport protein; Provisional; Region: cysT; CHL00187 83332006689 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 83332006690 dimer interface [polypeptide binding]; other site 83332006691 conserved gate region; other site 83332006692 putative PBP binding loops; other site 83332006693 ABC-ATPase subunit interface; other site 83332006694 sulfate transport protein; Provisional; Region: cysT; CHL00187 83332006695 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 83332006696 dimer interface [polypeptide binding]; other site 83332006697 conserved gate region; other site 83332006698 putative PBP binding loops; other site 83332006699 ABC-ATPase subunit interface; other site 83332006700 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 83332006701 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 83332006702 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 83332006703 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 83332006704 PknH-like extracellular domain; Region: PknH_C; pfam14032 83332006705 GTP-binding protein LepA; Provisional; Region: PRK05433 83332006706 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 83332006707 G1 box; other site 83332006708 putative GEF interaction site [polypeptide binding]; other site 83332006709 GTP/Mg2+ binding site [chemical binding]; other site 83332006710 Switch I region; other site 83332006711 G2 box; other site 83332006712 G3 box; other site 83332006713 Switch II region; other site 83332006714 G4 box; other site 83332006715 G5 box; other site 83332006716 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 83332006717 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 83332006718 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 83332006719 PemK-like protein; Region: PemK; pfam02452 83332006720 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 83332006721 FOG: CBS domain [General function prediction only]; Region: COG0517 83332006722 ribonuclease Z; Reviewed; Region: PRK00055 83332006723 PE family; Region: PE; pfam00934 83332006724 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 83332006725 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 83332006726 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 83332006727 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 83332006728 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 83332006729 Uncharacterized conserved protein [Function unknown]; Region: COG2308 83332006730 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 83332006731 hypothetical protein; Reviewed; Region: PRK07914 83332006732 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 83332006733 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 83332006734 Competence protein; Region: Competence; pfam03772 83332006735 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 83332006736 Helix-hairpin-helix motif; Region: HHH; pfam00633 83332006737 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 83332006738 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 83332006739 Coenzyme A binding pocket [chemical binding]; other site 83332006740 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 83332006741 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 83332006742 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 83332006743 active site 83332006744 catalytic triad [active] 83332006745 oxyanion hole [active] 83332006746 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 83332006747 catalytic core [active] 83332006748 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 83332006749 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 83332006750 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 83332006751 active site 83332006752 (T/H)XGH motif; other site 83332006753 Methyltransferase domain; Region: Methyltransf_23; pfam13489 83332006754 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332006755 S-adenosylmethionine binding site [chemical binding]; other site 83332006756 Transposase; Region: DEDD_Tnp_IS110; pfam01548 83332006757 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 83332006758 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 83332006759 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 83332006760 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 83332006761 metal ion-dependent adhesion site (MIDAS); other site 83332006762 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 83332006763 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 83332006764 Walker A motif; other site 83332006765 ATP binding site [chemical binding]; other site 83332006766 Walker B motif; other site 83332006767 arginine finger; other site 83332006768 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 83332006769 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 83332006770 putative catalytic cysteine [active] 83332006771 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 83332006772 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 83332006773 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 83332006774 dimer interface [polypeptide binding]; other site 83332006775 decamer (pentamer of dimers) interface [polypeptide binding]; other site 83332006776 catalytic triad [active] 83332006777 peroxidatic and resolving cysteines [active] 83332006778 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 83332006779 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 83332006780 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332006781 PPE family; Region: PPE; pfam00823 83332006782 PE family; Region: PE; pfam00934 83332006783 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 83332006784 Mechanosensitive ion channel; Region: MS_channel; pfam00924 83332006785 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 83332006786 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 83332006787 ligand binding site [chemical binding]; other site 83332006788 flexible hinge region; other site 83332006789 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 83332006790 dimerization interface [polypeptide binding]; other site 83332006791 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 83332006792 cyclase homology domain; Region: CHD; cd07302 83332006793 nucleotidyl binding site; other site 83332006794 metal binding site [ion binding]; metal-binding site 83332006795 dimer interface [polypeptide binding]; other site 83332006796 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 83332006797 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 83332006798 substrate binding site [chemical binding]; other site 83332006799 dimer interface [polypeptide binding]; other site 83332006800 ATP binding site [chemical binding]; other site 83332006801 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 83332006802 NAD synthetase; Reviewed; Region: nadE; PRK02628 83332006803 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 83332006804 multimer interface [polypeptide binding]; other site 83332006805 active site 83332006806 catalytic triad [active] 83332006807 protein interface 1 [polypeptide binding]; other site 83332006808 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 83332006809 homodimer interface [polypeptide binding]; other site 83332006810 NAD binding pocket [chemical binding]; other site 83332006811 ATP binding pocket [chemical binding]; other site 83332006812 Mg binding site [ion binding]; other site 83332006813 active-site loop [active] 83332006814 gamma-glutamyl kinase; Provisional; Region: PRK05429 83332006815 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 83332006816 nucleotide binding site [chemical binding]; other site 83332006817 homotetrameric interface [polypeptide binding]; other site 83332006818 putative phosphate binding site [ion binding]; other site 83332006819 putative allosteric binding site; other site 83332006820 PUA domain; Region: PUA; pfam01472 83332006821 GTPase CgtA; Reviewed; Region: obgE; PRK12296 83332006822 GTP1/OBG; Region: GTP1_OBG; pfam01018 83332006823 Obg GTPase; Region: Obg; cd01898 83332006824 G1 box; other site 83332006825 GTP/Mg2+ binding site [chemical binding]; other site 83332006826 Switch I region; other site 83332006827 G2 box; other site 83332006828 G3 box; other site 83332006829 Switch II region; other site 83332006830 G4 box; other site 83332006831 G5 box; other site 83332006832 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 83332006833 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 83332006834 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 83332006835 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 83332006836 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 83332006837 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 83332006838 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 83332006839 homodimer interface [polypeptide binding]; other site 83332006840 oligonucleotide binding site [chemical binding]; other site 83332006841 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 83332006842 active site 83332006843 multimer interface [polypeptide binding]; other site 83332006844 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 83332006845 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 83332006846 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 83332006847 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 83332006848 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 83332006849 active site 83332006850 HIGH motif; other site 83332006851 nucleotide binding site [chemical binding]; other site 83332006852 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 83332006853 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 83332006854 active site 83332006855 KMSKS motif; other site 83332006856 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 83332006857 tRNA binding surface [nucleotide binding]; other site 83332006858 anticodon binding site; other site 83332006859 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 83332006860 Uncharacterized conserved protein [Function unknown]; Region: COG3268 83332006861 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 83332006862 NAD(P) binding pocket [chemical binding]; other site 83332006863 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 83332006864 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 83332006865 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 83332006866 GTP binding site; other site 83332006867 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 83332006868 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 83332006869 TPP-binding site [chemical binding]; other site 83332006870 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 83332006871 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 83332006872 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 83332006873 dimer interface [polypeptide binding]; other site 83332006874 PYR/PP interface [polypeptide binding]; other site 83332006875 TPP binding site [chemical binding]; other site 83332006876 substrate binding site [chemical binding]; other site 83332006877 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 83332006878 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 83332006879 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 83332006880 Walker A motif; other site 83332006881 ATP binding site [chemical binding]; other site 83332006882 Walker B motif; other site 83332006883 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 83332006884 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 83332006885 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 83332006886 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 83332006887 Major Facilitator Superfamily; Region: MFS_1; pfam07690 83332006888 putative substrate translocation pore; other site 83332006889 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 83332006890 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 83332006891 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 83332006892 oligomer interface [polypeptide binding]; other site 83332006893 active site residues [active] 83332006894 Clp protease; Region: CLP_protease; pfam00574 83332006895 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 83332006896 oligomer interface [polypeptide binding]; other site 83332006897 active site residues [active] 83332006898 trigger factor; Provisional; Region: tig; PRK01490 83332006899 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 83332006900 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 83332006901 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 83332006902 Beta-lactamase; Region: Beta-lactamase; pfam00144 83332006903 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 83332006904 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 83332006905 putative DNA binding site [nucleotide binding]; other site 83332006906 catalytic residue [active] 83332006907 putative H2TH interface [polypeptide binding]; other site 83332006908 putative catalytic residues [active] 83332006909 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 83332006910 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 83332006911 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 83332006912 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 83332006913 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 83332006914 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 83332006915 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 83332006916 Zn binding site [ion binding]; other site 83332006917 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 83332006918 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 83332006919 active site 83332006920 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 83332006921 apolar tunnel; other site 83332006922 heme binding site [chemical binding]; other site 83332006923 dimerization interface [polypeptide binding]; other site 83332006924 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 83332006925 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 83332006926 active site 83332006927 catalytic site [active] 83332006928 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 83332006929 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 83332006930 active site 83332006931 NAD-specific glutamate dehydrogenase [Amino acid transport and metabolism]; Region: COG2902 83332006932 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 83332006933 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 83332006934 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 83332006935 ABC transporter; Region: ABC_tran_2; pfam12848 83332006936 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 83332006937 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 83332006938 dimer interface [polypeptide binding]; other site 83332006939 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 83332006940 ssDNA binding site [nucleotide binding]; other site 83332006941 tetramer (dimer of dimers) interface [polypeptide binding]; other site 83332006942 putative transposase OrfB; Reviewed; Region: PHA02517 83332006943 HTH-like domain; Region: HTH_21; pfam13276 83332006944 Integrase core domain; Region: rve; pfam00665 83332006945 Integrase core domain; Region: rve_3; pfam13683 83332006946 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 83332006947 Transposase; Region: HTH_Tnp_1; cl17663 83332006948 glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355 83332006949 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 83332006950 putative acyl-acceptor binding pocket; other site 83332006951 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 83332006952 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 83332006953 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 83332006954 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 83332006955 putative acyl-acceptor binding pocket; other site 83332006956 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 83332006957 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 83332006958 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 83332006959 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 83332006960 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 83332006961 enoyl-CoA hydratase; Provisional; Region: PRK05870 83332006962 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 83332006963 substrate binding site [chemical binding]; other site 83332006964 oxyanion hole (OAH) forming residues; other site 83332006965 trimer interface [polypeptide binding]; other site 83332006966 PE family; Region: PE; pfam00934 83332006967 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 83332006968 cyclase homology domain; Region: CHD; cd07302 83332006969 nucleotidyl binding site; other site 83332006970 metal binding site [ion binding]; metal-binding site 83332006971 dimer interface [polypeptide binding]; other site 83332006972 Predicted ATPase [General function prediction only]; Region: COG3903 83332006973 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 83332006974 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 83332006975 DNA binding residues [nucleotide binding] 83332006976 dimerization interface [polypeptide binding]; other site 83332006977 PE family; Region: PE; pfam00934 83332006978 TIGR00725 family protein; Region: TIGR00725 83332006979 thymidylate synthase; Provisional; Region: thyA; PRK00956 83332006980 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 83332006981 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 83332006982 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 83332006983 E3 interaction surface; other site 83332006984 lipoyl attachment site [posttranslational modification]; other site 83332006985 e3 binding domain; Region: E3_binding; pfam02817 83332006986 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 83332006987 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 83332006988 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 83332006989 alpha subunit interface [polypeptide binding]; other site 83332006990 TPP binding site [chemical binding]; other site 83332006991 heterodimer interface [polypeptide binding]; other site 83332006992 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 83332006993 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 83332006994 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 83332006995 tetramer interface [polypeptide binding]; other site 83332006996 TPP-binding site [chemical binding]; other site 83332006997 heterodimer interface [polypeptide binding]; other site 83332006998 phosphorylation loop region [posttranslational modification] 83332006999 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 83332007000 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 83332007001 putative active site [active] 83332007002 putative catalytic site [active] 83332007003 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332007004 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 83332007005 active site 83332007006 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 83332007007 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 83332007008 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 83332007009 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 83332007010 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 83332007011 carboxyltransferase (CT) interaction site; other site 83332007012 biotinylation site [posttranslational modification]; other site 83332007013 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 83332007014 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 83332007015 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 83332007016 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 83332007017 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 83332007018 AMP-binding domain protein; Validated; Region: PRK08315 83332007019 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 83332007020 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 83332007021 acyl-activating enzyme (AAE) consensus motif; other site 83332007022 acyl-activating enzyme (AAE) consensus motif; other site 83332007023 putative AMP binding site [chemical binding]; other site 83332007024 putative active site [active] 83332007025 putative CoA binding site [chemical binding]; other site 83332007026 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332007027 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332007028 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 83332007029 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 83332007030 classical (c) SDRs; Region: SDR_c; cd05233 83332007031 NAD(P) binding site [chemical binding]; other site 83332007032 active site 83332007033 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 83332007034 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 83332007035 catalytic site [active] 83332007036 putative active site [active] 83332007037 putative substrate binding site [chemical binding]; other site 83332007038 dimer interface [polypeptide binding]; other site 83332007039 Transposase, Mutator family; Region: Transposase_mut; pfam00872 83332007040 MULE transposase domain; Region: MULE; pfam10551 83332007041 Domain of unknown function (DUF4411); Region: DUF4411; pfam14367 83332007042 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 83332007043 non-specific DNA binding site [nucleotide binding]; other site 83332007044 salt bridge; other site 83332007045 sequence-specific DNA binding site [nucleotide binding]; other site 83332007046 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 83332007047 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893 83332007048 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 83332007049 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 83332007050 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 83332007051 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 83332007052 PE family; Region: PE; pfam00934 83332007053 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 83332007054 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 83332007055 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 83332007056 catalytic triad [active] 83332007057 hypothetical protein; Provisional; Region: PRK07907 83332007058 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 83332007059 active site 83332007060 metal binding site [ion binding]; metal-binding site 83332007061 dimer interface [polypeptide binding]; other site 83332007062 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 83332007063 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 83332007064 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 83332007065 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 83332007066 phosphate binding site [ion binding]; other site 83332007067 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 83332007068 FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447 83332007069 putative active site [active] 83332007070 putative catalytic site [active] 83332007071 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 83332007072 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 83332007073 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 83332007074 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 83332007075 putative NAD(P) binding site [chemical binding]; other site 83332007076 active site 83332007077 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 83332007078 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 83332007079 active site 83332007080 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 83332007081 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 83332007082 putative active site [active] 83332007083 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 83332007084 Mrr N-terminal domain; Region: Mrr_N; pfam14338 83332007085 Restriction endonuclease; Region: Mrr_cat; pfam04471 83332007086 ERCC4 domain; Region: ERCC4; pfam02732 83332007087 Lsr2; Region: Lsr2; pfam11774 83332007088 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 83332007089 putative active site [active] 83332007090 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 83332007091 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 83332007092 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 83332007093 catalytic residue [active] 83332007094 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 83332007095 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 83332007096 putative RNA binding site [nucleotide binding]; other site 83332007097 elongation factor P; Validated; Region: PRK00529 83332007098 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 83332007099 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 83332007100 RNA binding site [nucleotide binding]; other site 83332007101 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 83332007102 RNA binding site [nucleotide binding]; other site 83332007103 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 83332007104 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 83332007105 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 83332007106 active site 83332007107 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 83332007108 Dehydroquinase class II; Region: DHquinase_II; pfam01220 83332007109 trimer interface [polypeptide binding]; other site 83332007110 active site 83332007111 dimer interface [polypeptide binding]; other site 83332007112 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 83332007113 active site 83332007114 dimer interface [polypeptide binding]; other site 83332007115 metal binding site [ion binding]; metal-binding site 83332007116 shikimate kinase; Reviewed; Region: aroK; PRK00131 83332007117 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 83332007118 ADP binding site [chemical binding]; other site 83332007119 magnesium binding site [ion binding]; other site 83332007120 putative shikimate binding site; other site 83332007121 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 83332007122 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 83332007123 Tetramer interface [polypeptide binding]; other site 83332007124 active site 83332007125 FMN-binding site [chemical binding]; other site 83332007126 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 83332007127 digalactosyldiacylglycerol synthase; Region: PLN02846 83332007128 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 83332007129 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 83332007130 putative active site [active] 83332007131 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 83332007132 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 83332007133 oligomeric interface; other site 83332007134 putative active site [active] 83332007135 homodimer interface [polypeptide binding]; other site 83332007136 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402 83332007137 putative active site [active] 83332007138 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 83332007139 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 83332007140 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 83332007141 shikimate-5-dehydrogenase, fungal AROM-type; Region: Shik-DH-AROM; TIGR01809 83332007142 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 83332007143 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 83332007144 NAD(P) binding site [chemical binding]; other site 83332007145 shikimate binding site; other site 83332007146 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 83332007147 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 83332007148 dimerization interface [polypeptide binding]; other site 83332007149 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 83332007150 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 83332007151 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 83332007152 motif 1; other site 83332007153 active site 83332007154 motif 2; other site 83332007155 motif 3; other site 83332007156 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 83332007157 DHHA1 domain; Region: DHHA1; pfam02272 83332007158 Uncharacterized conserved protein [Function unknown]; Region: COG0432 83332007159 recombination factor protein RarA; Reviewed; Region: PRK13342 83332007160 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 83332007161 Walker A motif; other site 83332007162 ATP binding site [chemical binding]; other site 83332007163 Walker B motif; other site 83332007164 arginine finger; other site 83332007165 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 83332007166 Predicted integral membrane protein [Function unknown]; Region: COG5473 83332007167 Protein of unknown function (DUF2652); Region: DUF2652; pfam10851 83332007168 Protein of unknown function (DUF2652); Region: DUF2652; pfam10851 83332007169 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 83332007170 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 83332007171 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 83332007172 Walker A/P-loop; other site 83332007173 ATP binding site [chemical binding]; other site 83332007174 Q-loop/lid; other site 83332007175 ABC transporter signature motif; other site 83332007176 Walker B; other site 83332007177 D-loop; other site 83332007178 H-loop/switch region; other site 83332007179 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 83332007180 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 83332007181 ligand binding site [chemical binding]; other site 83332007182 flexible hinge region; other site 83332007183 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 83332007184 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 83332007185 ligand binding site [chemical binding]; other site 83332007186 flexible hinge region; other site 83332007187 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 83332007188 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 83332007189 active site 83332007190 nucleophile elbow; other site 83332007191 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 83332007192 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 83332007193 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 83332007194 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 83332007195 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 83332007196 Uncharacterized conserved protein [Function unknown]; Region: COG2308 83332007197 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 83332007198 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 83332007199 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 83332007200 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 83332007201 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 83332007202 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 83332007203 Transglutaminase/protease-like homologues; Region: TGc; smart00460 83332007204 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3801 83332007205 Predicted membrane protein [Function unknown]; Region: COG4129 83332007206 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 83332007207 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 83332007208 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 83332007209 dimer interface [polypeptide binding]; other site 83332007210 anticodon binding site; other site 83332007211 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 83332007212 homodimer interface [polypeptide binding]; other site 83332007213 motif 1; other site 83332007214 active site 83332007215 motif 2; other site 83332007216 GAD domain; Region: GAD; pfam02938 83332007217 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 83332007218 active site 83332007219 motif 3; other site 83332007220 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 83332007221 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 83332007222 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 83332007223 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 83332007224 putative hydrophobic ligand binding site [chemical binding]; other site 83332007225 protein interface [polypeptide binding]; other site 83332007226 gate; other site 83332007227 Predicted metalloprotease [General function prediction only]; Region: COG2321 83332007228 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 83332007229 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 83332007230 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 83332007231 active site 83332007232 metal binding site [ion binding]; metal-binding site 83332007233 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 83332007234 haloalkane dehalogenase; Provisional; Region: PRK03592 83332007235 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 83332007236 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 83332007237 dimer interface [polypeptide binding]; other site 83332007238 motif 1; other site 83332007239 active site 83332007240 motif 2; other site 83332007241 motif 3; other site 83332007242 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 83332007243 anticodon binding site; other site 83332007244 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 83332007245 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 83332007246 active site 83332007247 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 83332007248 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 83332007249 Zn2+ binding site [ion binding]; other site 83332007250 Mg2+ binding site [ion binding]; other site 83332007251 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 83332007252 synthetase active site [active] 83332007253 NTP binding site [chemical binding]; other site 83332007254 metal binding site [ion binding]; metal-binding site 83332007255 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 83332007256 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 83332007257 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 83332007258 active site 83332007259 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 83332007260 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 83332007261 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 83332007262 Protein export membrane protein; Region: SecD_SecF; pfam02355 83332007263 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 83332007264 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 83332007265 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05886 83332007266 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 83332007267 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 83332007268 inhibitor-cofactor binding pocket; inhibition site 83332007269 pyridoxal 5'-phosphate binding site [chemical binding]; other site 83332007270 catalytic residue [active] 83332007271 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 83332007272 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 83332007273 acyl-activating enzyme (AAE) consensus motif; other site 83332007274 AMP binding site [chemical binding]; other site 83332007275 active site 83332007276 CoA binding site [chemical binding]; other site 83332007277 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 83332007278 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 83332007279 putative NAD(P) binding site [chemical binding]; other site 83332007280 active site 83332007281 putative substrate binding site [chemical binding]; other site 83332007282 PE family; Region: PE; pfam00934 83332007283 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 83332007284 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 83332007285 Walker A motif; other site 83332007286 ATP binding site [chemical binding]; other site 83332007287 Walker B motif; other site 83332007288 arginine finger; other site 83332007289 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 83332007290 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 83332007291 RuvA N terminal domain; Region: RuvA_N; pfam01330 83332007292 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 83332007293 active site 83332007294 putative DNA-binding cleft [nucleotide binding]; other site 83332007295 dimer interface [polypeptide binding]; other site 83332007296 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 83332007297 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 83332007298 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 83332007299 putative active site [active] 83332007300 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 83332007301 Protein of unknown function DUF2617; Region: DUF2617; pfam10936 83332007302 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 83332007303 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 83332007304 Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only]; Region: COG4262 83332007305 Spermine/spermidine synthase; Region: Spermine_synth; pfam01564 83332007306 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 83332007307 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 83332007308 hypothetical protein; Validated; Region: PRK00110 83332007309 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 83332007310 predicted active site [active] 83332007311 catalytic triad [active] 83332007312 acyl-CoA thioesterase II; Region: tesB; TIGR00189 83332007313 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 83332007314 active site 83332007315 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 83332007316 catalytic triad [active] 83332007317 dimer interface [polypeptide binding]; other site 83332007318 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 83332007319 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 83332007320 active site 83332007321 multimer interface [polypeptide binding]; other site 83332007322 Pyridoxamine-phosphate oxidase [Coenzyme metabolism]; Region: PdxH; COG0259 83332007323 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 83332007324 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 83332007325 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332007326 PPE family; Region: PPE; pfam00823 83332007327 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332007328 PE-PPE domain; Region: PE-PPE; pfam08237 83332007329 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 83332007330 nudix motif; other site 83332007331 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 83332007332 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 83332007333 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 83332007334 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 83332007335 putative acyl-acceptor binding pocket; other site 83332007336 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 83332007337 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 83332007338 nucleotide binding site/active site [active] 83332007339 HIT family signature motif; other site 83332007340 catalytic residue [active] 83332007341 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 83332007342 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 83332007343 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 83332007344 active site 83332007345 dimer interface [polypeptide binding]; other site 83332007346 motif 1; other site 83332007347 motif 2; other site 83332007348 motif 3; other site 83332007349 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 83332007350 anticodon binding site; other site 83332007351 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 83332007352 phosphate binding site [ion binding]; other site 83332007353 PE family; Region: PE; pfam00934 83332007354 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4762 83332007355 Predicted transcriptional regulator [Transcription]; Region: COG2345 83332007356 Helix-turn-helix domain; Region: HTH_20; pfam12840 83332007357 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 83332007358 Predicted transcriptional regulator [Transcription]; Region: COG2345 83332007359 Helix-turn-helix domain; Region: HTH_20; pfam12840 83332007360 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332007361 S-adenosylmethionine binding site [chemical binding]; other site 83332007362 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 83332007363 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 83332007364 Ligand Binding Site [chemical binding]; other site 83332007365 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 83332007366 Ligand Binding Site [chemical binding]; other site 83332007367 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 83332007368 Ligand Binding Site [chemical binding]; other site 83332007369 Universal stress protein family; Region: Usp; pfam00582 83332007370 Ligand Binding Site [chemical binding]; other site 83332007371 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 83332007372 active site 83332007373 Peptidase family M50; Region: Peptidase_M50; pfam02163 83332007374 putative substrate binding region [chemical binding]; other site 83332007375 FOG: CBS domain [General function prediction only]; Region: COG0517 83332007376 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 83332007377 FOG: CBS domain [General function prediction only]; Region: COG0517 83332007378 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 83332007379 peptide chain release factor 1; Provisional; Region: PRK04011 83332007380 SHS2 domain protein implicated in nucleic acid metabolism [General function prediction only]; Region: COG1371 83332007381 Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690 83332007382 hypothetical protein; Reviewed; Region: PRK09588 83332007383 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 83332007384 Hemerythrin-like domain; Region: Hr-like; cd12108 83332007385 Fe binding site [ion binding]; other site 83332007386 PE family; Region: PE; pfam00934 83332007387 Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cd00227 83332007388 P-loop motif; other site 83332007389 ATP binding site [chemical binding]; other site 83332007390 Chloramphenicol (Cm) binding site [chemical binding]; other site 83332007391 catalytic residue [active] 83332007392 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 83332007393 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 83332007394 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 83332007395 anti sigma factor interaction site; other site 83332007396 regulatory phosphorylation site [posttranslational modification]; other site 83332007397 hypothetical protein; Provisional; Region: PRK02237 83332007398 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 83332007399 Transcriptional regulators [Transcription]; Region: MarR; COG1846 83332007400 putative DNA binding site [nucleotide binding]; other site 83332007401 putative Zn2+ binding site [ion binding]; other site 83332007402 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 83332007403 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 83332007404 putative metal binding site [ion binding]; other site 83332007405 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 83332007406 dimerization interface [polypeptide binding]; other site 83332007407 putative DNA binding site [nucleotide binding]; other site 83332007408 putative Zn2+ binding site [ion binding]; other site 83332007409 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 83332007410 arsenical-resistance protein; Region: acr3; TIGR00832 83332007411 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 83332007412 Low molecular weight phosphatase family; Region: LMWPc; cd00115 83332007413 active site 83332007414 Protein of unknown function (DUF3018); Region: DUF3018; pfam11455 83332007415 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 83332007416 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 83332007417 active site 83332007418 DNA binding site [nucleotide binding] 83332007419 Int/Topo IB signature motif; other site 83332007420 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 83332007421 Transposase; Region: HTH_Tnp_1; cl17663 83332007422 putative transposase OrfB; Reviewed; Region: PHA02517 83332007423 HTH-like domain; Region: HTH_21; pfam13276 83332007424 Integrase core domain; Region: rve; pfam00665 83332007425 Integrase core domain; Region: rve_3; pfam13683 83332007426 Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653 83332007427 Phage capsid family; Region: Phage_capsid; pfam05065 83332007428 Phage head maturation protease [General function prediction only]; Region: COG3740 83332007429 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: COG3747 83332007430 Protein of unknown function (DUF3631); Region: DUF3631; pfam12307 83332007431 Protein of unknown function (DUF2742); Region: DUF2742; pfam10888 83332007432 DNA binding domain, excisionase family; Region: excise; TIGR01764 83332007433 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 83332007434 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 83332007435 active site 83332007436 catalytic residues [active] 83332007437 DNA binding site [nucleotide binding] 83332007438 Int/Topo IB signature motif; other site 83332007439 Transposase, Mutator family; Region: Transposase_mut; pfam00872 83332007440 MULE transposase domain; Region: MULE; pfam10551 83332007441 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 83332007442 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 83332007443 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 83332007444 Coenzyme A binding pocket [chemical binding]; other site 83332007445 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 83332007446 hypothetical protein; Provisional; Region: PRK14059 83332007447 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 83332007448 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 83332007449 TAP-like protein; Region: Abhydrolase_4; pfam08386 83332007450 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 83332007451 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 83332007452 SelR domain; Region: SelR; pfam01641 83332007453 Methyltransferase domain; Region: Methyltransf_31; pfam13847 83332007454 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332007455 S-adenosylmethionine binding site [chemical binding]; other site 83332007456 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 83332007457 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 83332007458 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 83332007459 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 83332007460 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 83332007461 substrate binding site [chemical binding]; other site 83332007462 active site 83332007463 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 83332007464 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 83332007465 substrate binding site [chemical binding]; other site 83332007466 oxyanion hole (OAH) forming residues; other site 83332007467 trimer interface [polypeptide binding]; other site 83332007468 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 83332007469 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 83332007470 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 83332007471 catalytic site [active] 83332007472 putative active site [active] 83332007473 putative substrate binding site [chemical binding]; other site 83332007474 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 83332007475 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 83332007476 TPP-binding site; other site 83332007477 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 83332007478 PYR/PP interface [polypeptide binding]; other site 83332007479 dimer interface [polypeptide binding]; other site 83332007480 TPP binding site [chemical binding]; other site 83332007481 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 83332007482 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 83332007483 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 83332007484 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 83332007485 transmembrane helices; other site 83332007486 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 83332007487 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 83332007488 transmembrane helices; other site 83332007489 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 83332007490 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 83332007491 Walker A/P-loop; other site 83332007492 ATP binding site [chemical binding]; other site 83332007493 Q-loop/lid; other site 83332007494 ABC transporter signature motif; other site 83332007495 Walker B; other site 83332007496 D-loop; other site 83332007497 H-loop/switch region; other site 83332007498 TRAM domain; Region: TRAM; cl01282 83332007499 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 83332007500 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 83332007501 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 83332007502 TrkA-N domain; Region: TrkA_N; pfam02254 83332007503 TrkA-C domain; Region: TrkA_C; pfam02080 83332007504 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 83332007505 TrkA-N domain; Region: TrkA_N; pfam02254 83332007506 TrkA-C domain; Region: TrkA_C; pfam02080 83332007507 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 83332007508 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 83332007509 generic binding surface II; other site 83332007510 ssDNA binding site; other site 83332007511 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 83332007512 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 83332007513 trimer interface [polypeptide binding]; other site 83332007514 active site 83332007515 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 83332007516 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 83332007517 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 83332007518 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 83332007519 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 83332007520 active site 83332007521 dimerization interface [polypeptide binding]; other site 83332007522 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 83332007523 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 83332007524 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 83332007525 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 83332007526 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 83332007527 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 83332007528 DNA binding residues [nucleotide binding] 83332007529 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 83332007530 homotrimer interaction site [polypeptide binding]; other site 83332007531 putative active site [active] 83332007532 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502 83332007533 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 83332007534 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 83332007535 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 83332007536 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 83332007537 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 83332007538 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 83332007539 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 83332007540 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 83332007541 DNA binding residues [nucleotide binding] 83332007542 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 83332007543 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 83332007544 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 83332007545 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 83332007546 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 83332007547 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 83332007548 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 83332007549 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 83332007550 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 83332007551 PAC2 family; Region: PAC2; pfam09754 83332007552 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 83332007553 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 83332007554 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 83332007555 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 83332007556 heme-binding site [chemical binding]; other site 83332007557 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 83332007558 ATP cone domain; Region: ATP-cone; pfam03477 83332007559 LysM domain; Region: LysM; pfam01476 83332007560 LexA repressor; Validated; Region: PRK00215 83332007561 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 83332007562 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 83332007563 Catalytic site [active] 83332007564 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 83332007565 LGFP repeat; Region: LGFP; pfam08310 83332007566 LGFP repeat; Region: LGFP; pfam08310 83332007567 LGFP repeat; Region: LGFP; pfam08310 83332007568 LGFP repeat; Region: LGFP; pfam08310 83332007569 LGFP repeat; Region: LGFP; pfam08310 83332007570 Integral membrane protein TerC family; Region: TerC; cl10468 83332007571 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332007572 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 83332007573 active site 83332007574 GTPases [General function prediction only]; Region: HflX; COG2262 83332007575 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 83332007576 HflX GTPase family; Region: HflX; cd01878 83332007577 G1 box; other site 83332007578 GTP/Mg2+ binding site [chemical binding]; other site 83332007579 Switch I region; other site 83332007580 G2 box; other site 83332007581 G3 box; other site 83332007582 Switch II region; other site 83332007583 G4 box; other site 83332007584 G5 box; other site 83332007585 diaminopimelate epimerase; Region: DapF; TIGR00652 83332007586 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 83332007587 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 83332007588 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 83332007589 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 83332007590 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 83332007591 active site 83332007592 metal binding site [ion binding]; metal-binding site 83332007593 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 83332007594 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 83332007595 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 83332007596 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 83332007597 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 83332007598 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 83332007599 FeS/SAM binding site; other site 83332007600 TRAM domain; Region: TRAM; cl01282 83332007601 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 83332007602 FeS/SAM binding site; other site 83332007603 Uncharacterized protein conserved in bacteria [General function prediction only]; Region: OraA; COG2137 83332007604 DNA recombination protein RecA; Reviewed; Region: recA; PRK09519 83332007605 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 83332007606 hexamer interface [polypeptide binding]; other site 83332007607 Walker A motif; other site 83332007608 ATP binding site [chemical binding]; other site 83332007609 Walker B motif; other site 83332007610 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 83332007611 protein-splicing catalytic site; other site 83332007612 thioester formation/cholesterol transfer; other site 83332007613 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 83332007614 recA bacterial DNA recombination protein; Region: RecA; cl17211 83332007615 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 83332007616 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 83332007617 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 83332007618 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 83332007619 Limonene-1,2-epoxide hydrolase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LimA; COG4308 83332007620 PE family; Region: PE; pfam00934 83332007621 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 83332007622 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 83332007623 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 83332007624 non-specific DNA binding site [nucleotide binding]; other site 83332007625 salt bridge; other site 83332007626 sequence-specific DNA binding site [nucleotide binding]; other site 83332007627 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 83332007628 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 83332007629 Coenzyme A binding pocket [chemical binding]; other site 83332007630 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 83332007631 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 83332007632 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 83332007633 Uncharacterized conserved protein [Function unknown]; Region: COG1359 83332007634 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 83332007635 classical (c) SDRs; Region: SDR_c; cd05233 83332007636 NAD(P) binding site [chemical binding]; other site 83332007637 active site 83332007638 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 83332007639 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 83332007640 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 83332007641 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 83332007642 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 83332007643 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 83332007644 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 83332007645 dimer interface [polypeptide binding]; other site 83332007646 active site 83332007647 catalytic residue [active] 83332007648 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 83332007649 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 83332007650 HsdM N-terminal domain; Region: HsdM_N; pfam12161 83332007651 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 83332007652 Methyltransferase domain; Region: Methyltransf_26; pfam13659 83332007653 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 83332007654 putative active site [active] 83332007655 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 83332007656 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 83332007657 putative active site [active] 83332007658 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 83332007659 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 83332007660 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 83332007661 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 83332007662 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 83332007663 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 83332007664 folate binding site [chemical binding]; other site 83332007665 NADP+ binding site [chemical binding]; other site 83332007666 thymidylate synthase; Reviewed; Region: thyA; PRK01827 83332007667 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 83332007668 dimerization interface [polypeptide binding]; other site 83332007669 active site 83332007670 Dienelactone hydrolase family; Region: DLH; pfam01738 83332007671 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 83332007672 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 83332007673 classical (c) SDRs; Region: SDR_c; cd05233 83332007674 NAD(P) binding site [chemical binding]; other site 83332007675 active site 83332007676 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332007677 PPE family; Region: PPE; pfam00823 83332007678 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 83332007679 PE family; Region: PE; pfam00934 83332007680 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 83332007681 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332007682 PPE family; Region: PPE; pfam00823 83332007683 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 83332007684 dihydrodipicolinate reductase; Provisional; Region: PRK00048 83332007685 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 83332007686 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 83332007687 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 83332007688 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 83332007689 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 83332007690 Coenzyme A binding pocket [chemical binding]; other site 83332007691 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 83332007692 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 83332007693 FMN-binding pocket [chemical binding]; other site 83332007694 flavin binding motif; other site 83332007695 phosphate binding motif [ion binding]; other site 83332007696 beta-alpha-beta structure motif; other site 83332007697 NAD binding pocket [chemical binding]; other site 83332007698 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 83332007699 catalytic loop [active] 83332007700 iron binding site [ion binding]; other site 83332007701 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 83332007702 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 83332007703 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 83332007704 hydrophobic ligand binding site; other site 83332007705 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 83332007706 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 83332007707 putative DNA binding site [nucleotide binding]; other site 83332007708 putative Zn2+ binding site [ion binding]; other site 83332007709 AsnC family; Region: AsnC_trans_reg; pfam01037 83332007710 alanine dehydrogenase; Region: alaDH; TIGR00518 83332007711 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 83332007712 hexamer interface [polypeptide binding]; other site 83332007713 ligand binding site [chemical binding]; other site 83332007714 putative active site [active] 83332007715 NAD(P) binding site [chemical binding]; other site 83332007716 Nitronate monooxygenase; Region: NMO; pfam03060 83332007717 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 83332007718 FMN binding site [chemical binding]; other site 83332007719 substrate binding site [chemical binding]; other site 83332007720 putative catalytic residue [active] 83332007721 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 83332007722 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 83332007723 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 83332007724 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 83332007725 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 83332007726 oligomer interface [polypeptide binding]; other site 83332007727 RNA binding site [nucleotide binding]; other site 83332007728 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 83332007729 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 83332007730 RNase E interface [polypeptide binding]; other site 83332007731 trimer interface [polypeptide binding]; other site 83332007732 active site 83332007733 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 83332007734 putative nucleic acid binding region [nucleotide binding]; other site 83332007735 G-X-X-G motif; other site 83332007736 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 83332007737 RNA binding site [nucleotide binding]; other site 83332007738 domain interface; other site 83332007739 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 83332007740 16S/18S rRNA binding site [nucleotide binding]; other site 83332007741 S13e-L30e interaction site [polypeptide binding]; other site 83332007742 25S rRNA binding site [nucleotide binding]; other site 83332007743 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 83332007744 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 83332007745 active site 83332007746 Riboflavin kinase; Region: Flavokinase; pfam01687 83332007747 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 83332007748 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 83332007749 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 83332007750 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 83332007751 putative DNA binding site [nucleotide binding]; other site 83332007752 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 83332007753 FeoA domain; Region: FeoA; pfam04023 83332007754 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332007755 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 83332007756 active site 83332007757 lipid-transfer protein; Provisional; Region: PRK08256 83332007758 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 83332007759 active site 83332007760 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 83332007761 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 83332007762 Probable transposase; Region: OrfB_IS605; pfam01385 83332007763 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 83332007764 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 83332007765 catalytic residues [active] 83332007766 catalytic nucleophile [active] 83332007767 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 83332007768 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 83332007769 RNA binding site [nucleotide binding]; other site 83332007770 active site 83332007771 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 83332007772 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 83332007773 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 83332007774 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 83332007775 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 83332007776 active site 83332007777 metal binding site [ion binding]; metal-binding site 83332007778 Uncharacterized conserved protein [Function unknown]; Region: COG4717 83332007779 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 83332007780 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 83332007781 Predicted acyl esterases [General function prediction only]; Region: COG2936 83332007782 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 83332007783 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 83332007784 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 83332007785 Uncharacterized conserved protein [Function unknown]; Region: COG5586 83332007786 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 83332007787 Integrase core domain; Region: rve; pfam00665 83332007788 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 83332007789 Transposase; Region: DDE_Tnp_ISL3; pfam01610 83332007790 Helix-turn-helix domain; Region: HTH_28; pfam13518 83332007791 Winged helix-turn helix; Region: HTH_29; pfam13551 83332007792 Integrase core domain; Region: rve; pfam00665 83332007793 Integrase core domain; Region: rve_3; pfam13683 83332007794 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 83332007795 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 83332007796 putative transposase OrfB; Reviewed; Region: PHA02517 83332007797 HTH-like domain; Region: HTH_21; pfam13276 83332007798 Integrase core domain; Region: rve; pfam00665 83332007799 Integrase core domain; Region: rve_3; pfam13683 83332007800 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 83332007801 Transposase; Region: HTH_Tnp_1; cl17663 83332007802 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 83332007803 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09636 83332007804 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cd09699 83332007805 CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cd09662 83332007806 CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cd09663 83332007807 CRISPR/Cas system-associated RAMP superfamily protein Csm3; Region: Csm3_III-A; cd09684 83332007808 CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cd09647 83332007809 Predicted CRISPR-associated polymerase [Defense mechanisms]; Region: COG1353 83332007810 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 83332007811 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 83332007812 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4293 83332007813 Uncharacterized conserved protein [Function unknown]; Region: COG2253 83332007814 Protein of unknown function (DUF2005); Region: DUF2005; pfam09407 83332007815 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4293 83332007816 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 83332007817 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 83332007818 putative active site [active] 83332007819 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 83332007820 enoyl-CoA hydratase; Provisional; Region: PRK06190 83332007821 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 83332007822 substrate binding site [chemical binding]; other site 83332007823 oxyanion hole (OAH) forming residues; other site 83332007824 trimer interface [polypeptide binding]; other site 83332007825 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 83332007826 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 83332007827 Walker A/P-loop; other site 83332007828 ATP binding site [chemical binding]; other site 83332007829 Q-loop/lid; other site 83332007830 ABC transporter signature motif; other site 83332007831 Walker B; other site 83332007832 D-loop; other site 83332007833 H-loop/switch region; other site 83332007834 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 83332007835 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 83332007836 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 83332007837 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 83332007838 dimer interface [polypeptide binding]; other site 83332007839 conserved gate region; other site 83332007840 putative PBP binding loops; other site 83332007841 ABC-ATPase subunit interface; other site 83332007842 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 83332007843 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 83332007844 dimer interface [polypeptide binding]; other site 83332007845 conserved gate region; other site 83332007846 putative PBP binding loops; other site 83332007847 ABC-ATPase subunit interface; other site 83332007848 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 83332007849 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 83332007850 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 83332007851 DHH family; Region: DHH; pfam01368 83332007852 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 83332007853 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 83332007854 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 83332007855 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 83332007856 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 83332007857 G1 box; other site 83332007858 putative GEF interaction site [polypeptide binding]; other site 83332007859 GTP/Mg2+ binding site [chemical binding]; other site 83332007860 Switch I region; other site 83332007861 G2 box; other site 83332007862 G3 box; other site 83332007863 Switch II region; other site 83332007864 G4 box; other site 83332007865 G5 box; other site 83332007866 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 83332007867 Translation-initiation factor 2; Region: IF-2; pfam11987 83332007868 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 83332007869 Predicted nucleic-acid-binding protein implicated in transcription termination [Transcription]; Region: COG2740 83332007870 putative RNA binding cleft [nucleotide binding]; other site 83332007871 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 83332007872 NusA N-terminal domain; Region: NusA_N; pfam08529 83332007873 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 83332007874 RNA binding site [nucleotide binding]; other site 83332007875 homodimer interface [polypeptide binding]; other site 83332007876 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 83332007877 G-X-X-G motif; other site 83332007878 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 83332007879 G-X-X-G motif; other site 83332007880 ribosome maturation protein RimP; Reviewed; Region: PRK00092 83332007881 Sm and related proteins; Region: Sm_like; cl00259 83332007882 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 83332007883 putative oligomer interface [polypeptide binding]; other site 83332007884 putative RNA binding site [nucleotide binding]; other site 83332007885 Mitochondrial ATP synthase g subunit; Region: ATP-synt_G; pfam04718 83332007886 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 83332007887 dinuclear metal binding motif [ion binding]; other site 83332007888 prolyl-tRNA synthetase; Provisional; Region: PRK09194 83332007889 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 83332007890 dimer interface [polypeptide binding]; other site 83332007891 motif 1; other site 83332007892 active site 83332007893 motif 2; other site 83332007894 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 83332007895 putative deacylase active site [active] 83332007896 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 83332007897 active site 83332007898 motif 3; other site 83332007899 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 83332007900 anticodon binding site; other site 83332007901 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 83332007902 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 83332007903 putative substrate translocation pore; other site 83332007904 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 83332007905 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 83332007906 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 83332007907 homodimer interface [polypeptide binding]; other site 83332007908 active site 83332007909 SAM binding site [chemical binding]; other site 83332007910 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 83332007911 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 83332007912 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 83332007913 catalytic triad [active] 83332007914 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 83332007915 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 83332007916 homodimer interface [polypeptide binding]; other site 83332007917 Walker A motif; other site 83332007918 ATP binding site [chemical binding]; other site 83332007919 hydroxycobalamin binding site [chemical binding]; other site 83332007920 Walker B motif; other site 83332007921 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 83332007922 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 83332007923 Walker A motif; other site 83332007924 ATP binding site [chemical binding]; other site 83332007925 Walker B motif; other site 83332007926 arginine finger; other site 83332007927 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 83332007928 metal ion-dependent adhesion site (MIDAS); other site 83332007929 Predicted acyltransferase [General function prediction only]; Region: ElaA; COG2153 83332007930 malate:quinone oxidoreductase; Validated; Region: PRK05257 83332007931 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 83332007932 PE family; Region: PE; pfam00934 83332007933 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 83332007934 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 83332007935 mycothione reductase; Reviewed; Region: PRK07846 83332007936 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 83332007937 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 83332007938 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 83332007939 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 83332007940 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 83332007941 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 83332007942 short chain dehydrogenase; Provisional; Region: PRK06057 83332007943 classical (c) SDRs; Region: SDR_c; cd05233 83332007944 NAD(P) binding site [chemical binding]; other site 83332007945 active site 83332007946 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 83332007947 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 83332007948 NAD(P) binding site [chemical binding]; other site 83332007949 catalytic residues [active] 83332007950 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 83332007951 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 83332007952 catalytic triad [active] 83332007953 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 83332007954 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 83332007955 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 83332007956 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 83332007957 active site 83332007958 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 83332007959 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 83332007960 putative active site [active] 83332007961 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 83332007962 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 83332007963 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 83332007964 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 83332007965 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 83332007966 Predicted acetyltransferase [General function prediction only]; Region: COG3393 83332007967 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 83332007968 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 83332007969 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 83332007970 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 83332007971 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 83332007972 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 83332007973 active site 83332007974 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 83332007975 protein binding site [polypeptide binding]; other site 83332007976 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 83332007977 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 83332007978 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 83332007979 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 83332007980 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 83332007981 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 83332007982 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 83332007983 Fasciclin domain; Region: Fasciclin; pfam02469 83332007984 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 83332007985 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 83332007986 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 83332007987 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 83332007988 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 83332007989 catalytic residues [active] 83332007990 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 83332007991 Fasciclin domain; Region: Fasciclin; pfam02469 83332007992 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 83332007993 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 83332007994 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 83332007995 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 83332007996 catalytic residues [active] 83332007997 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 83332007998 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 83332007999 ribosome recycling factor; Reviewed; Region: frr; PRK00083 83332008000 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 83332008001 hinge region; other site 83332008002 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 83332008003 putative nucleotide binding site [chemical binding]; other site 83332008004 uridine monophosphate binding site [chemical binding]; other site 83332008005 homohexameric interface [polypeptide binding]; other site 83332008006 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 83332008007 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 83332008008 DNA binding site [nucleotide binding] 83332008009 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 83332008010 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 83332008011 Probable transposase; Region: OrfB_IS605; pfam01385 83332008012 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 83332008013 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 83332008014 catalytic residues [active] 83332008015 catalytic nucleophile [active] 83332008016 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 83332008017 MarR family; Region: MarR; pfam01047 83332008018 amidase; Provisional; Region: PRK07869 83332008019 Amidase; Region: Amidase; pfam01425 83332008020 elongation factor Ts; Provisional; Region: tsf; PRK09377 83332008021 UBA/TS-N domain; Region: UBA; pfam00627 83332008022 Elongation factor TS; Region: EF_TS; pfam00889 83332008023 Elongation factor TS; Region: EF_TS; pfam00889 83332008024 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 83332008025 rRNA interaction site [nucleotide binding]; other site 83332008026 S8 interaction site; other site 83332008027 putative laminin-1 binding site; other site 83332008028 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 83332008029 Peptidase family M23; Region: Peptidase_M23; pfam01551 83332008030 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332008031 PPE family; Region: PPE; pfam00823 83332008032 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 83332008033 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 83332008034 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 83332008035 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 83332008036 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 83332008037 active site 83332008038 DNA binding site [nucleotide binding] 83332008039 Int/Topo IB signature motif; other site 83332008040 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 83332008041 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 83332008042 FAD binding pocket [chemical binding]; other site 83332008043 FAD binding motif [chemical binding]; other site 83332008044 phosphate binding motif [ion binding]; other site 83332008045 NAD binding pocket [chemical binding]; other site 83332008046 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 83332008047 DNA protecting protein DprA; Region: dprA; TIGR00732 83332008048 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 83332008049 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 83332008050 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 83332008051 Walker A motif; other site 83332008052 ATP binding site [chemical binding]; other site 83332008053 Walker B motif; other site 83332008054 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 83332008055 hypothetical protein; Reviewed; Region: PRK12497 83332008056 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 83332008057 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 83332008058 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 83332008059 putative molybdopterin cofactor binding site [chemical binding]; other site 83332008060 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 83332008061 putative molybdopterin cofactor binding site; other site 83332008062 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 83332008063 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 83332008064 RNA/DNA hybrid binding site [nucleotide binding]; other site 83332008065 active site 83332008066 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 83332008067 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 83332008068 Catalytic site [active] 83332008069 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 83332008070 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 83332008071 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 83332008072 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 83332008073 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 83332008074 RimM N-terminal domain; Region: RimM; pfam01782 83332008075 hypothetical protein; Provisional; Region: PRK02821 83332008076 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 83332008077 G-X-X-G motif; other site 83332008078 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 83332008079 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 83332008080 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 83332008081 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 83332008082 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332008083 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332008084 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 83332008085 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 83332008086 active site 83332008087 putative substrate binding pocket [chemical binding]; other site 83332008088 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 83332008089 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 83332008090 Catalytic domain of Protein Kinases; Region: PKc; cd00180 83332008091 active site 83332008092 ATP binding site [chemical binding]; other site 83332008093 substrate binding site [chemical binding]; other site 83332008094 activation loop (A-loop); other site 83332008095 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 83332008096 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 83332008097 active site 83332008098 signal recognition particle protein; Provisional; Region: PRK10867 83332008099 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 83332008100 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 83332008101 P loop; other site 83332008102 GTP binding site [chemical binding]; other site 83332008103 Signal peptide binding domain; Region: SRP_SPB; pfam02978 83332008104 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 83332008105 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 83332008106 ATP binding site [chemical binding]; other site 83332008107 putative Mg++ binding site [ion binding]; other site 83332008108 PII uridylyl-transferase; Provisional; Region: PRK03381 83332008109 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 83332008110 metal binding triad; other site 83332008111 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 83332008112 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 83332008113 Zn2+ binding site [ion binding]; other site 83332008114 Mg2+ binding site [ion binding]; other site 83332008115 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 83332008116 Nitrogen regulatory protein P-II; Region: P-II; smart00938 83332008117 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 83332008118 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 83332008119 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 83332008120 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 83332008121 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 83332008122 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 83332008123 Walker A/P-loop; other site 83332008124 ATP binding site [chemical binding]; other site 83332008125 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 83332008126 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 83332008127 ABC transporter signature motif; other site 83332008128 Walker B; other site 83332008129 D-loop; other site 83332008130 H-loop/switch region; other site 83332008131 acylphosphatase; Provisional; Region: PRK14422 83332008132 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 83332008133 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 83332008134 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 83332008135 DNA binding site [nucleotide binding] 83332008136 catalytic residue [active] 83332008137 H2TH interface [polypeptide binding]; other site 83332008138 putative catalytic residues [active] 83332008139 turnover-facilitating residue; other site 83332008140 intercalation triad [nucleotide binding]; other site 83332008141 8OG recognition residue [nucleotide binding]; other site 83332008142 putative reading head residues; other site 83332008143 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 83332008144 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 83332008145 ribonuclease III; Reviewed; Region: rnc; PRK00102 83332008146 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 83332008147 dimerization interface [polypeptide binding]; other site 83332008148 active site 83332008149 metal binding site [ion binding]; metal-binding site 83332008150 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 83332008151 dsRNA binding site [nucleotide binding]; other site 83332008152 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 83332008153 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 83332008154 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 83332008155 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 83332008156 acyl-CoA synthetase; Validated; Region: PRK05850 83332008157 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 83332008158 acyl-activating enzyme (AAE) consensus motif; other site 83332008159 active site 83332008160 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 83332008161 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 83332008162 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 83332008163 active site 83332008164 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 83332008165 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 83332008166 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 83332008167 NADP binding site [chemical binding]; other site 83332008168 KR domain; Region: KR; pfam08659 83332008169 active site 83332008170 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 83332008171 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 83332008172 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 83332008173 active site 83332008174 Acyl transferase domain; Region: Acyl_transf_1; cl08282 83332008175 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 83332008176 KR domain; Region: KR; pfam08659 83332008177 NADP binding site [chemical binding]; other site 83332008178 active site 83332008179 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 83332008180 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 83332008181 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 83332008182 active site 83332008183 Acyl transferase domain; Region: Acyl_transf_1; cl08282 83332008184 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 83332008185 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 83332008186 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 83332008187 Enoylreductase; Region: PKS_ER; smart00829 83332008188 NAD(P) binding site [chemical binding]; other site 83332008189 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 83332008190 KR domain; Region: KR; pfam08659 83332008191 putative NADP binding site [chemical binding]; other site 83332008192 active site 83332008193 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 83332008194 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 83332008195 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 83332008196 active site 83332008197 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 83332008198 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 83332008199 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 83332008200 KR domain; Region: KR; pfam08659 83332008201 putative NADP binding site [chemical binding]; other site 83332008202 active site 83332008203 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 83332008204 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 83332008205 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 83332008206 active site 83332008207 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 83332008208 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 83332008209 Condensation domain; Region: Condensation; pfam00668 83332008210 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 83332008211 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 83332008212 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 83332008213 Walker A/P-loop; other site 83332008214 ATP binding site [chemical binding]; other site 83332008215 Q-loop/lid; other site 83332008216 ABC transporter signature motif; other site 83332008217 Walker B; other site 83332008218 D-loop; other site 83332008219 H-loop/switch region; other site 83332008220 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 83332008221 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 83332008222 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 83332008223 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 83332008224 acyltransferase PapA5; Provisional; Region: PRK09294 83332008225 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 83332008226 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 83332008227 active site 83332008228 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 83332008229 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 83332008230 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 83332008231 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 83332008232 Enoylreductase; Region: PKS_ER; smart00829 83332008233 NAD(P) binding site [chemical binding]; other site 83332008234 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 83332008235 KR domain; Region: KR; pfam08659 83332008236 putative NADP binding site [chemical binding]; other site 83332008237 active site 83332008238 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 83332008239 acyl-CoA synthetase; Validated; Region: PRK05850 83332008240 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 83332008241 acyl-activating enzyme (AAE) consensus motif; other site 83332008242 active site 83332008243 MMPL family; Region: MMPL; pfam03176 83332008244 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 83332008245 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 83332008246 Integrase core domain; Region: rve; pfam00665 83332008247 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 83332008248 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 83332008249 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 83332008250 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 83332008251 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 83332008252 Enoylreductase; Region: PKS_ER; smart00829 83332008253 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 83332008254 NAD(P) binding site [chemical binding]; other site 83332008255 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 83332008256 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 83332008257 putative NADP binding site [chemical binding]; other site 83332008258 active site 83332008259 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 83332008260 Erythronolide synthase docking; Region: Docking; pfam08990 83332008261 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 83332008262 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 83332008263 active site 83332008264 acyl-CoA synthetase; Validated; Region: PRK06060 83332008265 Benzoate CoA ligase (BCL) and similar adenylate forming enzymes; Region: BCL_like; cd05919 83332008266 dimer interface [polypeptide binding]; other site 83332008267 acyl-activating enzyme (AAE) consensus motif; other site 83332008268 putative active site [active] 83332008269 putative AMP binding site [chemical binding]; other site 83332008270 putative CoA binding site [chemical binding]; other site 83332008271 chemical substrate binding site [chemical binding]; other site 83332008272 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 83332008273 4-hydroxybenzoate synthetase (chorismate lyase) [Coenzyme metabolism]; Region: UbiC; COG3161 83332008274 acyl-CoA synthetase; Validated; Region: PRK05850 83332008275 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 83332008276 acyl-activating enzyme (AAE) consensus motif; other site 83332008277 active site 83332008278 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 83332008279 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 83332008280 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332008281 S-adenosylmethionine binding site [chemical binding]; other site 83332008282 Uncharacterized conserved protein [Function unknown]; Region: COG3268 83332008283 Methyltransferase domain; Region: Methyltransf_23; pfam13489 83332008284 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332008285 S-adenosylmethionine binding site [chemical binding]; other site 83332008286 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 83332008287 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 83332008288 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 83332008289 metal-binding site 83332008290 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 83332008291 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 83332008292 active site 83332008293 TDP-binding site; other site 83332008294 acceptor substrate-binding pocket; other site 83332008295 Cephalosporin hydroxylase [Defense mechanisms]; Region: CmcI; COG3510 83332008296 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 83332008297 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 83332008298 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 83332008299 active site 83332008300 TDP-binding site; other site 83332008301 acceptor substrate-binding pocket; other site 83332008302 Predicted permease; Region: DUF318; pfam03773 83332008303 formyltetrahydrofolate deformylase; Region: PurU; TIGR00655 83332008304 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 83332008305 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 83332008306 putative active site [active] 83332008307 putative substrate binding site [chemical binding]; other site 83332008308 putative cosubstrate binding site; other site 83332008309 catalytic site [active] 83332008310 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 83332008311 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 83332008312 active site 83332008313 (T/H)XGH motif; other site 83332008314 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 83332008315 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332008316 S-adenosylmethionine binding site [chemical binding]; other site 83332008317 pyruvate carboxylase; Reviewed; Region: PRK12999 83332008318 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 83332008319 ATP-grasp domain; Region: ATP-grasp_4; cl17255 83332008320 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 83332008321 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 83332008322 active site 83332008323 catalytic residues [active] 83332008324 metal binding site [ion binding]; metal-binding site 83332008325 homodimer binding site [polypeptide binding]; other site 83332008326 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 83332008327 carboxyltransferase (CT) interaction site; other site 83332008328 biotinylation site [posttranslational modification]; other site 83332008329 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 83332008330 putative active site [active] 83332008331 redox center [active] 83332008332 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 83332008333 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 83332008334 catalytic residues [active] 83332008335 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 83332008336 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 83332008337 substrate binding pocket [chemical binding]; other site 83332008338 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 83332008339 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 83332008340 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 83332008341 active site 83332008342 catalytic tetrad [active] 83332008343 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 83332008344 RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200 83332008345 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 83332008346 generic binding surface II; other site 83332008347 ssDNA binding site; other site 83332008348 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 83332008349 ATP binding site [chemical binding]; other site 83332008350 putative Mg++ binding site [ion binding]; other site 83332008351 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 83332008352 nucleotide binding region [chemical binding]; other site 83332008353 ATP-binding site [chemical binding]; other site 83332008354 DAK2 domain; Region: Dak2; cl03685 83332008355 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 83332008356 DAK2 domain; Region: Dak2; cl03685 83332008357 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 83332008358 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 83332008359 ligand binding site [chemical binding]; other site 83332008360 active site 83332008361 UGI interface [polypeptide binding]; other site 83332008362 catalytic site [active] 83332008363 thiamine monophosphate kinase; Provisional; Region: PRK05731 83332008364 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 83332008365 ATP binding site [chemical binding]; other site 83332008366 dimerization interface [polypeptide binding]; other site 83332008367 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 83332008368 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 83332008369 Probable transposase; Region: OrfB_IS605; pfam01385 83332008370 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 83332008371 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 83332008372 catalytic residues [active] 83332008373 catalytic nucleophile [active] 83332008374 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 83332008375 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 83332008376 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 83332008377 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 83332008378 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 83332008379 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 83332008380 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 83332008381 Predicted nucleotidyltransferase, CobY/MobA/RfbA family [General function prediction only]; Region: COG1920 83332008382 polyphosphate kinase; Provisional; Region: PRK05443 83332008383 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 83332008384 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 83332008385 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 83332008386 putative domain interface [polypeptide binding]; other site 83332008387 putative active site [active] 83332008388 catalytic site [active] 83332008389 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 83332008390 putative domain interface [polypeptide binding]; other site 83332008391 putative active site [active] 83332008392 catalytic site [active] 83332008393 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 83332008394 active site 83332008395 Ap6A binding site [chemical binding]; other site 83332008396 nudix motif; other site 83332008397 metal binding site [ion binding]; metal-binding site 83332008398 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 83332008399 catalytic core [active] 83332008400 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 83332008401 IHF - DNA interface [nucleotide binding]; other site 83332008402 IHF dimer interface [polypeptide binding]; other site 83332008403 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 83332008404 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 83332008405 substrate binding site [chemical binding]; other site 83332008406 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 83332008407 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 83332008408 substrate binding site [chemical binding]; other site 83332008409 ligand binding site [chemical binding]; other site 83332008410 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 83332008411 Transcriptional regulator [Transcription]; Region: IclR; COG1414 83332008412 Bacterial transcriptional regulator; Region: IclR; pfam01614 83332008413 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332008414 S-adenosylmethionine binding site [chemical binding]; other site 83332008415 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 83332008416 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 83332008417 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 83332008418 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 83332008419 active site 83332008420 HIGH motif; other site 83332008421 nucleotide binding site [chemical binding]; other site 83332008422 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 83332008423 active site 83332008424 KMSKS motif; other site 83332008425 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 83332008426 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 83332008427 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 83332008428 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 83332008429 Major Facilitator Superfamily; Region: MFS_1; pfam07690 83332008430 putative substrate translocation pore; other site 83332008431 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 83332008432 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 83332008433 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 83332008434 ligand binding site [chemical binding]; other site 83332008435 NAD binding site [chemical binding]; other site 83332008436 dimerization interface [polypeptide binding]; other site 83332008437 catalytic site [active] 83332008438 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 83332008439 putative L-serine binding site [chemical binding]; other site 83332008440 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 83332008441 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 83332008442 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 83332008443 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 83332008444 phosphorylation site [posttranslational modification] 83332008445 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 83332008446 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 83332008447 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 83332008448 ketol-acid reductoisomerase; Provisional; Region: PRK05479 83332008449 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 83332008450 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 83332008451 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 83332008452 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 83332008453 putative valine binding site [chemical binding]; other site 83332008454 dimer interface [polypeptide binding]; other site 83332008455 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 83332008456 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 83332008457 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 83332008458 PYR/PP interface [polypeptide binding]; other site 83332008459 dimer interface [polypeptide binding]; other site 83332008460 TPP binding site [chemical binding]; other site 83332008461 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 83332008462 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 83332008463 TPP-binding site [chemical binding]; other site 83332008464 dimer interface [polypeptide binding]; other site 83332008465 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 83332008466 Predicted membrane protein [Function unknown]; Region: COG2259 83332008467 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 83332008468 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 83332008469 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 83332008470 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 83332008471 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 83332008472 GatB domain; Region: GatB_Yqey; smart00845 83332008473 6-phosphofructokinase; Provisional; Region: PRK03202 83332008474 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 83332008475 active site 83332008476 ADP/pyrophosphate binding site [chemical binding]; other site 83332008477 dimerization interface [polypeptide binding]; other site 83332008478 allosteric effector site; other site 83332008479 fructose-1,6-bisphosphate binding site; other site 83332008480 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 83332008481 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 83332008482 aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, C subunit; Region: gatC; TIGR00135 83332008483 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 83332008484 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 83332008485 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 83332008486 nucleotide binding pocket [chemical binding]; other site 83332008487 K-X-D-G motif; other site 83332008488 catalytic site [active] 83332008489 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 83332008490 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 83332008491 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 83332008492 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 83332008493 Dimer interface [polypeptide binding]; other site 83332008494 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 83332008495 PknH-like extracellular domain; Region: PknH_C; pfam14032 83332008496 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 83332008497 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332008498 PPE family; Region: PPE; pfam00823 83332008499 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 83332008500 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332008501 PPE family; Region: PPE; pfam00823 83332008502 Transposase, Mutator family; Region: Transposase_mut; pfam00872 83332008503 MULE transposase domain; Region: MULE; pfam10551 83332008504 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 83332008505 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 83332008506 Ligand Binding Site [chemical binding]; other site 83332008507 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 83332008508 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 83332008509 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 83332008510 catalytic residue [active] 83332008511 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 83332008512 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 83332008513 putative acyl-acceptor binding pocket; other site 83332008514 Putative hemolysin [General function prediction only]; Region: COG3176 83332008515 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 83332008516 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 83332008517 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 83332008518 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 83332008519 Ligand binding site [chemical binding]; other site 83332008520 Electron transfer flavoprotein domain; Region: ETF; pfam01012 83332008521 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332008522 S-adenosylmethionine binding site [chemical binding]; other site 83332008523 Uncharacterized conserved protein [Function unknown]; Region: COG1543 83332008524 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 83332008525 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 83332008526 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 83332008527 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 83332008528 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 83332008529 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 83332008530 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 83332008531 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 83332008532 trimer interface [polypeptide binding]; other site 83332008533 active site 83332008534 substrate binding site [chemical binding]; other site 83332008535 CoA binding site [chemical binding]; other site 83332008536 FOG: WD40-like repeat [Function unknown]; Region: COG1520 83332008537 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 83332008538 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332008539 S-adenosylmethionine binding site [chemical binding]; other site 83332008540 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 83332008541 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 83332008542 substrate binding site [chemical binding]; other site 83332008543 oxyanion hole (OAH) forming residues; other site 83332008544 trimer interface [polypeptide binding]; other site 83332008545 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 83332008546 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 83332008547 Walker A/P-loop; other site 83332008548 ATP binding site [chemical binding]; other site 83332008549 Q-loop/lid; other site 83332008550 ABC transporter signature motif; other site 83332008551 Walker B; other site 83332008552 D-loop; other site 83332008553 H-loop/switch region; other site 83332008554 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 83332008555 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 83332008556 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 83332008557 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 83332008558 motif II; other site 83332008559 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 83332008560 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 83332008561 D-pathway; other site 83332008562 Putative ubiquinol binding site [chemical binding]; other site 83332008563 Low-spin heme (heme b) binding site [chemical binding]; other site 83332008564 Putative water exit pathway; other site 83332008565 Binuclear center (heme o3/CuB) [ion binding]; other site 83332008566 K-pathway; other site 83332008567 Putative proton exit pathway; other site 83332008568 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 83332008569 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 83332008570 siderophore binding site; other site 83332008571 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 83332008572 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 83332008573 putative NAD(P) binding site [chemical binding]; other site 83332008574 putative substrate binding site [chemical binding]; other site 83332008575 catalytic Zn binding site [ion binding]; other site 83332008576 structural Zn binding site [ion binding]; other site 83332008577 dimer interface [polypeptide binding]; other site 83332008578 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 83332008579 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 83332008580 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 83332008581 dimer interface [polypeptide binding]; other site 83332008582 putative radical transfer pathway; other site 83332008583 diiron center [ion binding]; other site 83332008584 tyrosyl radical; other site 83332008585 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 83332008586 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 83332008587 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332008588 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332008589 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 83332008590 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 83332008591 Class I ribonucleotide reductase; Region: RNR_I; cd01679 83332008592 active site 83332008593 dimer interface [polypeptide binding]; other site 83332008594 catalytic residues [active] 83332008595 effector binding site; other site 83332008596 R2 peptide binding site; other site 83332008597 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 83332008598 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 83332008599 catalytic residues [active] 83332008600 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 83332008601 Predicted flavoprotein [General function prediction only]; Region: COG0431 83332008602 DNA polymerase IV; Validated; Region: PRK03352 83332008603 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 83332008604 active site 83332008605 DNA binding site [nucleotide binding] 83332008606 short chain dehydrogenase; Provisional; Region: PRK07832 83332008607 classical (c) SDRs; Region: SDR_c; cd05233 83332008608 NAD(P) binding site [chemical binding]; other site 83332008609 active site 83332008610 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332008611 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332008612 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 83332008613 Cytochrome P450; Region: p450; cl12078 83332008614 Transcriptional regulators [Transcription]; Region: FadR; COG2186 83332008615 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 83332008616 DNA-binding site [nucleotide binding]; DNA binding site 83332008617 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 83332008618 Transcriptional regulators [Transcription]; Region: FadR; COG2186 83332008619 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 83332008620 DNA-binding site [nucleotide binding]; DNA binding site 83332008621 FCD domain; Region: FCD; pfam07729 83332008622 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332008623 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 83332008624 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 83332008625 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332008626 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332008627 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 83332008628 active site 83332008629 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 83332008630 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 83332008631 active site 83332008632 DNA binding site [nucleotide binding] 83332008633 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 83332008634 DNA binding site [nucleotide binding] 83332008635 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 83332008636 Carbon starvation protein CstA; Region: CstA; pfam02554 83332008637 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 83332008638 Predicted membrane protein [Function unknown]; Region: COG2259 83332008639 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 83332008640 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 83332008641 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332008642 Protein of unknown function (DUF732); Region: DUF732; pfam05305 83332008643 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 83332008644 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 83332008645 active site 83332008646 substrate binding site [chemical binding]; other site 83332008647 metal binding site [ion binding]; metal-binding site 83332008648 camphor resistance protein CrcB; Provisional; Region: PRK14216 83332008649 camphor resistance protein CrcB; Provisional; Region: PRK14228 83332008650 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 83332008651 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 83332008652 Uncharacterized ACR, COG1993; Region: DUF190; pfam02641 83332008653 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 83332008654 Uncharacterized conserved protein [Function unknown]; Region: COG3189 83332008655 Domain of unknown function (DUF222); Region: DUF222; pfam02720 83332008656 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 83332008657 active site 83332008658 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 83332008659 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 83332008660 putative hydrophobic ligand binding site [chemical binding]; other site 83332008661 protein interface [polypeptide binding]; other site 83332008662 gate; other site 83332008663 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 83332008664 Sulfatase; Region: Sulfatase; pfam00884 83332008665 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 83332008666 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 83332008667 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 83332008668 Catalytic domain of Protein Kinases; Region: PKc; cd00180 83332008669 active site 83332008670 ATP binding site [chemical binding]; other site 83332008671 substrate binding site [chemical binding]; other site 83332008672 activation loop (A-loop); other site 83332008673 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 83332008674 AAA ATPase domain; Region: AAA_16; pfam13191 83332008675 Nucleotidyl transferase of unknown function (DUF2204); Region: DUF2204; pfam09970 83332008676 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 83332008677 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 83332008678 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 83332008679 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 83332008680 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 83332008681 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 83332008682 short chain dehydrogenase; Provisional; Region: PRK07832 83332008683 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 83332008684 NAD(P) binding site [chemical binding]; other site 83332008685 active site 83332008686 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 83332008687 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 83332008688 NAD binding site [chemical binding]; other site 83332008689 catalytic Zn binding site [ion binding]; other site 83332008690 substrate binding site [chemical binding]; other site 83332008691 structural Zn binding site [ion binding]; other site 83332008692 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 83332008693 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 83332008694 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 83332008695 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 83332008696 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 83332008697 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 83332008698 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 83332008699 acyl-activating enzyme (AAE) consensus motif; other site 83332008700 AMP binding site [chemical binding]; other site 83332008701 active site 83332008702 CoA binding site [chemical binding]; other site 83332008703 SPFH domain / Band 7 family; Region: Band_7; pfam01145 83332008704 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 83332008705 Patatin-like phospholipase; Region: Patatin; pfam01734 83332008706 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 83332008707 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 83332008708 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 83332008709 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332008710 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 83332008711 active site 83332008712 Predicted transcriptional regulators [Transcription]; Region: COG1733 83332008713 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 83332008714 dimerization interface [polypeptide binding]; other site 83332008715 putative DNA binding site [nucleotide binding]; other site 83332008716 putative Zn2+ binding site [ion binding]; other site 83332008717 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 83332008718 PE family; Region: PE; pfam00934 83332008719 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 83332008720 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 83332008721 De-etiolated protein 1 Det1; Region: Det1; pfam09737 83332008722 PemK-like protein; Region: PemK; pfam02452 83332008723 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 83332008724 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 83332008725 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 83332008726 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 83332008727 SmpB-tmRNA interface; other site 83332008728 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 83332008729 FtsX-like permease family; Region: FtsX; pfam02687 83332008730 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 83332008731 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 83332008732 Walker A/P-loop; other site 83332008733 ATP binding site [chemical binding]; other site 83332008734 Q-loop/lid; other site 83332008735 ABC transporter signature motif; other site 83332008736 Walker B; other site 83332008737 D-loop; other site 83332008738 H-loop/switch region; other site 83332008739 Mechanosensitive ion channel; Region: MS_channel; pfam00924 83332008740 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 83332008741 peptide chain release factor 2; Validated; Region: prfB; PRK00578 83332008742 This domain is found in peptide chain release factors; Region: PCRF; smart00937 83332008743 RF-1 domain; Region: RF-1; pfam00472 83332008744 ferredoxin-NADP+ reductase; Region: PLN02852 83332008745 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 83332008746 FAD binding domain; Region: FAD_binding_4; pfam01565 83332008747 Molybdenum cofactor biosynthesis enzyme [Coenzyme metabolism]; Region: MoaA; COG2896 83332008748 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 83332008749 FeS/SAM binding site; other site 83332008750 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 83332008751 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 83332008752 aromatic arch; other site 83332008753 DCoH dimer interaction site [polypeptide binding]; other site 83332008754 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 83332008755 DCoH tetramer interaction site [polypeptide binding]; other site 83332008756 substrate binding site [chemical binding]; other site 83332008757 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 83332008758 trimer interface [polypeptide binding]; other site 83332008759 dimer interface [polypeptide binding]; other site 83332008760 putative active site [active] 83332008761 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 83332008762 MoaE interaction surface [polypeptide binding]; other site 83332008763 MoeB interaction surface [polypeptide binding]; other site 83332008764 thiocarboxylated glycine; other site 83332008765 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 83332008766 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 83332008767 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 83332008768 nucleoside/Zn binding site; other site 83332008769 dimer interface [polypeptide binding]; other site 83332008770 catalytic motif [active] 83332008771 Transposase, Mutator family; Region: Transposase_mut; pfam00872 83332008772 MULE transposase domain; Region: MULE; pfam10551 83332008773 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 83332008774 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 83332008775 ATP binding site [chemical binding]; other site 83332008776 substrate interface [chemical binding]; other site 83332008777 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 83332008778 active site residue [active] 83332008779 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 83332008780 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 83332008781 active site residue [active] 83332008782 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 83332008783 active site residue [active] 83332008784 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 83332008785 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 83332008786 MoaE homodimer interface [polypeptide binding]; other site 83332008787 MoaD interaction [polypeptide binding]; other site 83332008788 active site residues [active] 83332008789 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332008790 S-adenosylmethionine binding site [chemical binding]; other site 83332008791 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 83332008792 Cytochrome P450; Region: p450; cl12078 83332008793 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 83332008794 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 83332008795 DNA binding site [nucleotide binding] 83332008796 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332008797 PPE family; Region: PPE; pfam00823 83332008798 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 83332008799 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 83332008800 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 83332008801 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 83332008802 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 83332008803 dimer interface [polypeptide binding]; other site 83332008804 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 83332008805 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 83332008806 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 83332008807 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 83332008808 Histidine kinase; Region: HisKA_3; pfam07730 83332008809 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 83332008810 ATP binding site [chemical binding]; other site 83332008811 Mg2+ binding site [ion binding]; other site 83332008812 G-X-G motif; other site 83332008813 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 83332008814 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 83332008815 active site 83332008816 phosphorylation site [posttranslational modification] 83332008817 intermolecular recognition site; other site 83332008818 dimerization interface [polypeptide binding]; other site 83332008819 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 83332008820 DNA binding residues [nucleotide binding] 83332008821 dimerization interface [polypeptide binding]; other site 83332008822 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 83332008823 Ligand Binding Site [chemical binding]; other site 83332008824 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332008825 PPE family; Region: PPE; pfam00823 83332008826 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332008827 PPE family; Region: PPE; pfam00823 83332008828 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 83332008829 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 83332008830 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 83332008831 active site 83332008832 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 83332008833 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 83332008834 FeS/SAM binding site; other site 83332008835 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332008836 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 83332008837 active site 83332008838 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332008839 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 83332008840 active site 83332008841 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 83332008842 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 83332008843 NAD(P) binding site [chemical binding]; other site 83332008844 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 83332008845 active site 83332008846 phosphorylation site [posttranslational modification] 83332008847 intermolecular recognition site; other site 83332008848 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332008849 PPE family; Region: PPE; pfam00823 83332008850 NADH dehydrogenase subunit A; Validated; Region: PRK07928 83332008851 NADH dehydrogenase subunit B; Validated; Region: PRK06411 83332008852 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 83332008853 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 83332008854 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 83332008855 NADH dehydrogenase subunit D; Validated; Region: PRK06075 83332008856 NADH dehydrogenase subunit E; Validated; Region: PRK07539 83332008857 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 83332008858 putative dimer interface [polypeptide binding]; other site 83332008859 [2Fe-2S] cluster binding site [ion binding]; other site 83332008860 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 83332008861 SLBB domain; Region: SLBB; pfam10531 83332008862 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 83332008863 NADH dehydrogenase subunit G; Validated; Region: PRK07860 83332008864 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 83332008865 catalytic loop [active] 83332008866 iron binding site [ion binding]; other site 83332008867 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 83332008868 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 83332008869 [4Fe-4S] binding site [ion binding]; other site 83332008870 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 83332008871 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 83332008872 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 83332008873 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 83332008874 4Fe-4S binding domain; Region: Fer4; pfam00037 83332008875 4Fe-4S binding domain; Region: Fer4; pfam00037 83332008876 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 83332008877 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 83332008878 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 83332008879 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 83332008880 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 83332008881 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 83332008882 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 83332008883 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 83332008884 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 83332008885 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332008886 PPE family; Region: PPE; pfam00823 83332008887 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 83332008888 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332008889 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 83332008890 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 83332008891 [2Fe-2S] cluster binding site [ion binding]; other site 83332008892 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_1; cd08885 83332008893 putative alpha subunit interface [polypeptide binding]; other site 83332008894 putative active site [active] 83332008895 putative substrate binding site [chemical binding]; other site 83332008896 Fe binding site [ion binding]; other site 83332008897 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 83332008898 Protein of unknown function DUF58; Region: DUF58; pfam01882 83332008899 MoxR-like ATPases [General function prediction only]; Region: COG0714 83332008900 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 83332008901 Walker A motif; other site 83332008902 ATP binding site [chemical binding]; other site 83332008903 Walker B motif; other site 83332008904 arginine finger; other site 83332008905 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 83332008906 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332008907 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332008908 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 83332008909 putative active site [active] 83332008910 putative substrate binding site [chemical binding]; other site 83332008911 ATP binding site [chemical binding]; other site 83332008912 Phosphotransferase enzyme family; Region: APH; pfam01636 83332008913 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 83332008914 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 83332008915 hydroxyglutarate oxidase; Provisional; Region: PRK11728 83332008916 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 83332008917 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 83332008918 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332008919 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332008920 short chain dehydrogenase; Validated; Region: PRK08264 83332008921 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 83332008922 NAD(P) binding site [chemical binding]; other site 83332008923 active site 83332008924 amidase; Provisional; Region: PRK06170 83332008925 Amidase; Region: Amidase; pfam01425 83332008926 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 83332008927 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 83332008928 TAP-like protein; Region: Abhydrolase_4; pfam08386 83332008929 Domain of unknown function (DUF385); Region: DUF385; pfam04075 83332008930 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 83332008931 AAA domain; Region: AAA_14; pfam13173 83332008932 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 83332008933 putative active site [active] 83332008934 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 83332008935 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4683 83332008936 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 83332008937 non-specific DNA binding site [nucleotide binding]; other site 83332008938 salt bridge; other site 83332008939 sequence-specific DNA binding site [nucleotide binding]; other site 83332008940 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 83332008941 Transposase; Region: HTH_Tnp_1; cl17663 83332008942 putative transposase OrfB; Reviewed; Region: PHA02517 83332008943 HTH-like domain; Region: HTH_21; pfam13276 83332008944 Integrase core domain; Region: rve; pfam00665 83332008945 Integrase core domain; Region: rve_3; pfam13683 83332008946 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 83332008947 Transposase; Region: HTH_Tnp_1; cl17663 83332008948 putative transposase OrfB; Reviewed; Region: PHA02517 83332008949 HTH-like domain; Region: HTH_21; pfam13276 83332008950 Integrase core domain; Region: rve; pfam00665 83332008951 Integrase core domain; Region: rve_3; pfam13683 83332008952 RES domain; Region: RES; pfam08808 83332008953 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 83332008954 Helix-turn-helix domain; Region: HTH_38; pfam13936 83332008955 Integrase core domain; Region: rve; pfam00665 83332008956 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 83332008957 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 83332008958 hypothetical protein; Validated; Region: PRK00068 83332008959 Uncharacterized conserved protein [Function unknown]; Region: COG1615 83332008960 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 83332008961 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 83332008962 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 83332008963 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 83332008964 Uncharacterized conserved protein [Function unknown]; Region: COG5282 83332008965 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 83332008966 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 83332008967 ABC1 family; Region: ABC1; pfam03109 83332008968 Phosphotransferase enzyme family; Region: APH; pfam01636 83332008969 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 83332008970 active site 83332008971 ATP binding site [chemical binding]; other site 83332008972 Transcription factor WhiB; Region: Whib; pfam02467 83332008973 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 83332008974 Part of AAA domain; Region: AAA_19; pfam13245 83332008975 Family description; Region: UvrD_C_2; pfam13538 83332008976 HRDC domain; Region: HRDC; pfam00570 83332008977 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 83332008978 catalytic residues [active] 83332008979 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 83332008980 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 83332008981 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 83332008982 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 83332008983 putative NADH binding site [chemical binding]; other site 83332008984 putative active site [active] 83332008985 nudix motif; other site 83332008986 putative metal binding site [ion binding]; other site 83332008987 Ion channel; Region: Ion_trans_2; pfam07885 83332008988 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 83332008989 TrkA-N domain; Region: TrkA_N; pfam02254 83332008990 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 83332008991 Part of AAA domain; Region: AAA_19; pfam13245 83332008992 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 83332008993 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 83332008994 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 83332008995 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 83332008996 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 83332008997 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 83332008998 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 83332008999 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 83332009000 active site 83332009001 DNA binding site [nucleotide binding] 83332009002 TIGR02569 family protein; Region: TIGR02569_actnb 83332009003 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 83332009004 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 83332009005 ATP binding site [chemical binding]; other site 83332009006 substrate interface [chemical binding]; other site 83332009007 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 83332009008 active site residue [active] 83332009009 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 83332009010 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332009011 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332009012 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 83332009013 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like; Region: MiaE_2; pfam13794 83332009014 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 83332009015 DEAD-like helicases superfamily; Region: DEXDc; smart00487 83332009016 ATP binding site [chemical binding]; other site 83332009017 Mg++ binding site [ion binding]; other site 83332009018 motif III; other site 83332009019 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 83332009020 nucleotide binding region [chemical binding]; other site 83332009021 ATP-binding site [chemical binding]; other site 83332009022 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 83332009023 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 83332009024 P-loop; other site 83332009025 Magnesium ion binding site [ion binding]; other site 83332009026 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 83332009027 Magnesium ion binding site [ion binding]; other site 83332009028 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 83332009029 catalytic core [active] 83332009030 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 83332009031 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 83332009032 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 83332009033 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 83332009034 Transcription factor WhiB; Region: Whib; pfam02467 83332009035 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 83332009036 PAS domain S-box; Region: sensory_box; TIGR00229 83332009037 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 83332009038 Histidine kinase; Region: HisKA_2; pfam07568 83332009039 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 83332009040 ATP binding site [chemical binding]; other site 83332009041 Mg2+ binding site [ion binding]; other site 83332009042 G-X-G motif; other site 83332009043 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 83332009044 carboxyltransferase (CT) interaction site; other site 83332009045 biotinylation site [posttranslational modification]; other site 83332009046 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 83332009047 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 83332009048 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 83332009049 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 83332009050 DNA binding residues [nucleotide binding] 83332009051 short chain dehydrogenase; Provisional; Region: PRK08278 83332009052 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 83332009053 NAD(P) binding site [chemical binding]; other site 83332009054 homodimer interface [polypeptide binding]; other site 83332009055 active site 83332009056 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 83332009057 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 83332009058 putative deacylase active site [active] 83332009059 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 83332009060 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 83332009061 Coenzyme A binding pocket [chemical binding]; other site 83332009062 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 83332009063 Phosphotransferase enzyme family; Region: APH; pfam01636 83332009064 putative active site [active] 83332009065 putative substrate binding site [chemical binding]; other site 83332009066 ATP binding site [chemical binding]; other site 83332009067 Uncharacterized conserved protein [Function unknown]; Region: COG2135 83332009068 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 83332009069 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 83332009070 hinge; other site 83332009071 active site 83332009072 Predicted GTPases [General function prediction only]; Region: COG1162 83332009073 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 83332009074 GTPase/Zn-binding domain interface [polypeptide binding]; other site 83332009075 GTP/Mg2+ binding site [chemical binding]; other site 83332009076 G4 box; other site 83332009077 G5 box; other site 83332009078 G1 box; other site 83332009079 Switch I region; other site 83332009080 G2 box; other site 83332009081 G3 box; other site 83332009082 Switch II region; other site 83332009083 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 83332009084 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 83332009085 putative di-iron ligands [ion binding]; other site 83332009086 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 83332009087 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 83332009088 FAD binding pocket [chemical binding]; other site 83332009089 FAD binding motif [chemical binding]; other site 83332009090 phosphate binding motif [ion binding]; other site 83332009091 beta-alpha-beta structure motif; other site 83332009092 NAD binding pocket [chemical binding]; other site 83332009093 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 83332009094 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 83332009095 catalytic loop [active] 83332009096 iron binding site [ion binding]; other site 83332009097 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 83332009098 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 83332009099 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 83332009100 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 83332009101 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 83332009102 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 83332009103 TrkA-C domain; Region: TrkA_C; pfam02080 83332009104 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 83332009105 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 83332009106 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 83332009107 putative substrate translocation pore; other site 83332009108 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 83332009109 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 83332009110 ligand binding site [chemical binding]; other site 83332009111 flexible hinge region; other site 83332009112 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 83332009113 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 83332009114 nucleophile elbow; other site 83332009115 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 83332009116 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 83332009117 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 83332009118 30S subunit binding site; other site 83332009119 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 83332009120 active site 83332009121 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 83332009122 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 83332009123 lipoprotein LpqB; Provisional; Region: PRK13616 83332009124 Sporulation and spore germination; Region: Germane; pfam10646 83332009125 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 83332009126 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 83332009127 dimerization interface [polypeptide binding]; other site 83332009128 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 83332009129 dimer interface [polypeptide binding]; other site 83332009130 phosphorylation site [posttranslational modification] 83332009131 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 83332009132 ATP binding site [chemical binding]; other site 83332009133 Mg2+ binding site [ion binding]; other site 83332009134 G-X-G motif; other site 83332009135 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 83332009136 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 83332009137 active site 83332009138 phosphorylation site [posttranslational modification] 83332009139 intermolecular recognition site; other site 83332009140 dimerization interface [polypeptide binding]; other site 83332009141 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 83332009142 DNA binding site [nucleotide binding] 83332009143 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 83332009144 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 83332009145 TMP-binding site; other site 83332009146 ATP-binding site [chemical binding]; other site 83332009147 Adenosylhomocysteinase; Provisional; Region: PTZ00075 83332009148 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 83332009149 homotetramer interface [polypeptide binding]; other site 83332009150 ligand binding site [chemical binding]; other site 83332009151 catalytic site [active] 83332009152 NAD binding site [chemical binding]; other site 83332009153 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332009154 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 83332009155 Rubredoxin [Energy production and conversion]; Region: COG1773 83332009156 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 83332009157 iron binding site [ion binding]; other site 83332009158 Rubredoxin [Energy production and conversion]; Region: COG1773 83332009159 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 83332009160 iron binding site [ion binding]; other site 83332009161 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 83332009162 Fatty acid desaturase; Region: FA_desaturase; pfam00487 83332009163 Di-iron ligands [ion binding]; other site 83332009164 amino acid transporter; Region: 2A0306; TIGR00909 83332009165 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 83332009166 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 83332009167 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 83332009168 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 83332009169 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 83332009170 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 83332009171 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 83332009172 active site 83332009173 substrate binding site [chemical binding]; other site 83332009174 metal binding site [ion binding]; metal-binding site 83332009175 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 83332009176 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 83332009177 Transcription factor WhiB; Region: Whib; pfam02467 83332009178 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 83332009179 LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186 83332009180 phosphate binding site [ion binding]; other site 83332009181 dimer interface [polypeptide binding]; other site 83332009182 substrate binding site [chemical binding]; other site 83332009183 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 83332009184 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 83332009185 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 83332009186 putative FMN binding site [chemical binding]; other site 83332009187 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 83332009188 Methyltransferase domain; Region: Methyltransf_26; pfam13659 83332009189 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 83332009190 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 83332009191 active site 83332009192 Substrate binding site; other site 83332009193 Mg++ binding site; other site 83332009194 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 83332009195 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 83332009196 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 83332009197 Probable Catalytic site; other site 83332009198 metal-binding site 83332009199 dTDP-4-dehydrorhamnose reductase; Region: rmlD; TIGR01214 83332009200 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 83332009201 NADP binding site [chemical binding]; other site 83332009202 active site 83332009203 putative substrate binding site [chemical binding]; other site 83332009204 Transcriptional regulator [Transcription]; Region: LytR; COG1316 83332009205 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 83332009206 TIGR03089 family protein; Region: TIGR03089 83332009207 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 83332009208 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 83332009209 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 83332009210 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 83332009211 active site 83332009212 motif I; other site 83332009213 motif II; other site 83332009214 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 83332009215 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 83332009216 CoA-transferase family III; Region: CoA_transf_3; pfam02515 83332009217 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 83332009218 Sulfate transporter family; Region: Sulfate_transp; pfam00916 83332009219 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: CynT; COG0288 83332009220 active site clefts [active] 83332009221 zinc binding site [ion binding]; other site 83332009222 dimer interface [polypeptide binding]; other site 83332009223 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332009224 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 83332009225 FAD binding site [chemical binding]; other site 83332009226 homotetramer interface [polypeptide binding]; other site 83332009227 substrate binding pocket [chemical binding]; other site 83332009228 catalytic base [active] 83332009229 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 83332009230 Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) [Nucleotide transport and metabolism]; Region: PurK; COG0026 83332009231 ATP-grasp domain; Region: ATP-grasp; pfam02222 83332009232 Predicted membrane protein [Function unknown]; Region: COG2246 83332009233 GtrA-like protein; Region: GtrA; pfam04138 83332009234 Bacterial PH domain; Region: DUF304; pfam03703 83332009235 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 83332009236 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 83332009237 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 83332009238 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 83332009239 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 83332009240 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 83332009241 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 83332009242 Maf-like protein; Region: Maf; pfam02545 83332009243 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 83332009244 active site 83332009245 dimer interface [polypeptide binding]; other site 83332009246 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 83332009247 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 83332009248 active site residue [active] 83332009249 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 83332009250 active site residue [active] 83332009251 Fe-S metabolism associated domain; Region: SufE; pfam02657 83332009252 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 83332009253 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 83332009254 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 83332009255 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 83332009256 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 83332009257 carboxyltransferase (CT) interaction site; other site 83332009258 biotinylation site [posttranslational modification]; other site 83332009259 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 83332009260 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 83332009261 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 83332009262 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 83332009263 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 83332009264 L-lysine aminotransferase; Provisional; Region: PRK08297 83332009265 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 83332009266 inhibitor-cofactor binding pocket; inhibition site 83332009267 pyridoxal 5'-phosphate binding site [chemical binding]; other site 83332009268 catalytic residue [active] 83332009269 putative DNA binding site [nucleotide binding]; other site 83332009270 dimerization interface [polypeptide binding]; other site 83332009271 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 83332009272 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 83332009273 putative Zn2+ binding site [ion binding]; other site 83332009274 AsnC family; Region: AsnC_trans_reg; pfam01037 83332009275 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 83332009276 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 83332009277 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 83332009278 tetrameric interface [polypeptide binding]; other site 83332009279 NAD binding site [chemical binding]; other site 83332009280 catalytic residues [active] 83332009281 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 83332009282 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332009283 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332009284 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 83332009285 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 83332009286 ATP binding site [chemical binding]; other site 83332009287 putative Mg++ binding site [ion binding]; other site 83332009288 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 83332009289 nucleotide binding region [chemical binding]; other site 83332009290 ATP-binding site [chemical binding]; other site 83332009291 DEAD/H associated; Region: DEAD_assoc; pfam08494 83332009292 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 83332009293 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 83332009294 putative DNA binding site [nucleotide binding]; other site 83332009295 catalytic residue [active] 83332009296 putative H2TH interface [polypeptide binding]; other site 83332009297 putative catalytic residues [active] 83332009298 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 83332009299 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 83332009300 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 83332009301 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 83332009302 Sulfatase; Region: Sulfatase; pfam00884 83332009303 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 83332009304 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 83332009305 probable active site [active] 83332009306 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 83332009307 PhoU domain; Region: PhoU; pfam01895 83332009308 PhoU domain; Region: PhoU; pfam01895 83332009309 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 83332009310 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 83332009311 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 83332009312 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 83332009313 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 83332009314 putative active site pocket [active] 83332009315 dimerization interface [polypeptide binding]; other site 83332009316 putative catalytic residue [active] 83332009317 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 83332009318 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 83332009319 metal binding site [ion binding]; metal-binding site 83332009320 putative dimer interface [polypeptide binding]; other site 83332009321 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 83332009322 amidohydrolase; Region: amidohydrolases; TIGR01891 83332009323 metal binding site [ion binding]; metal-binding site 83332009324 purine nucleoside phosphorylase; Provisional; Region: PRK08202 83332009325 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 83332009326 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 83332009327 active site 83332009328 substrate binding site [chemical binding]; other site 83332009329 metal binding site [ion binding]; metal-binding site 83332009330 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 83332009331 active site 83332009332 Phosphoesterase family; Region: Phosphoesterase; pfam04185 83332009333 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 83332009334 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 83332009335 adenosine deaminase; Provisional; Region: PRK09358 83332009336 active site 83332009337 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 83332009338 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 83332009339 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 83332009340 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 83332009341 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 83332009342 active site 83332009343 catalytic motif [active] 83332009344 Zn binding site [ion binding]; other site 83332009345 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 83332009346 putative Iron-sulfur protein interface [polypeptide binding]; other site 83332009347 putative proximal heme binding site [chemical binding]; other site 83332009348 putative SdhD-like interface [polypeptide binding]; other site 83332009349 putative distal heme binding site [chemical binding]; other site 83332009350 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 83332009351 putative Iron-sulfur protein interface [polypeptide binding]; other site 83332009352 putative proximal heme binding site [chemical binding]; other site 83332009353 putative SdhC-like subunit interface [polypeptide binding]; other site 83332009354 putative distal heme binding site [chemical binding]; other site 83332009355 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 83332009356 L-aspartate oxidase; Provisional; Region: PRK06175 83332009357 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 83332009358 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 83332009359 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 83332009360 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 83332009361 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 83332009362 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332009363 S-adenosylmethionine binding site [chemical binding]; other site 83332009364 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 83332009365 MoaE interaction surface [polypeptide binding]; other site 83332009366 MoeB interaction surface [polypeptide binding]; other site 83332009367 thiocarboxylated glycine; other site 83332009368 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 83332009369 MoaE homodimer interface [polypeptide binding]; other site 83332009370 MoaD interaction [polypeptide binding]; other site 83332009371 active site residues [active] 83332009372 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 83332009373 trimer interface [polypeptide binding]; other site 83332009374 dimer interface [polypeptide binding]; other site 83332009375 putative active site [active] 83332009376 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 83332009377 Transposase; Region: HTH_Tnp_1; cl17663 83332009378 putative transposase OrfB; Reviewed; Region: PHA02517 83332009379 HTH-like domain; Region: HTH_21; pfam13276 83332009380 Integrase core domain; Region: rve; pfam00665 83332009381 Integrase core domain; Region: rve_3; pfam13683 83332009382 Transposase; Region: DEDD_Tnp_IS110; pfam01548 83332009383 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 83332009384 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 83332009385 Uncharacterized conserved protein [Function unknown]; Region: COG2128 83332009386 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 83332009387 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 83332009388 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 83332009389 DNA binding residues [nucleotide binding] 83332009390 SnoaL-like domain; Region: SnoaL_2; pfam12680 83332009391 hypothetical protein; Provisional; Region: PRK06541 83332009392 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 83332009393 inhibitor-cofactor binding pocket; inhibition site 83332009394 pyridoxal 5'-phosphate binding site [chemical binding]; other site 83332009395 catalytic residue [active] 83332009396 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 83332009397 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 83332009398 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 83332009399 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 83332009400 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 83332009401 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 83332009402 active site 83332009403 dimer interface [polypeptide binding]; other site 83332009404 Protein of unknown function (DUF732); Region: DUF732; pfam05305 83332009405 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 83332009406 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 83332009407 DNA binding residues [nucleotide binding] 83332009408 dimer interface [polypeptide binding]; other site 83332009409 metal binding site [ion binding]; metal-binding site 83332009410 inner membrane protein YhjD; Region: TIGR00766 83332009411 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 83332009412 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 83332009413 active site 83332009414 HIGH motif; other site 83332009415 dimer interface [polypeptide binding]; other site 83332009416 KMSKS motif; other site 83332009417 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 83332009418 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 83332009419 isocitrate dehydrogenase; Validated; Region: PRK08299 83332009420 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 83332009421 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 83332009422 homodimer interface [polypeptide binding]; other site 83332009423 substrate-cofactor binding pocket; other site 83332009424 pyridoxal 5'-phosphate binding site [chemical binding]; other site 83332009425 catalytic residue [active] 83332009426 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 83332009427 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 83332009428 Methyltransferase domain; Region: Methyltransf_23; pfam13489 83332009429 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332009430 S-adenosylmethionine binding site [chemical binding]; other site 83332009431 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332009432 PPE family; Region: PPE; pfam00823 83332009433 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332009434 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009435 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009436 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009437 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332009438 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009439 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009440 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332009441 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009442 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009443 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009444 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332009445 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009446 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009447 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009448 PE family; Region: PE; pfam00934 83332009449 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 83332009450 PPE family; Region: PPE; pfam00823 83332009451 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009452 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009453 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332009454 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009455 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009456 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332009457 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009458 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009459 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332009460 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009461 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009462 Transposase; Region: DEDD_Tnp_IS110; pfam01548 83332009463 Transposase; Region: DDE_Tnp_ISL3; pfam01610 83332009464 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332009465 PPE family; Region: PPE; pfam00823 83332009466 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332009467 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009468 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009469 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332009470 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009471 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009472 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009473 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009474 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332009475 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009476 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009477 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332009478 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009479 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009480 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009481 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009482 Berberine and berberine like; Region: BBE; pfam08031 83332009483 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 83332009484 Protein of unknown function (DUF732); Region: DUF732; pfam05305 83332009485 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 83332009486 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 83332009487 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 83332009488 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 83332009489 homodimer interface [polypeptide binding]; other site 83332009490 NADP binding site [chemical binding]; other site 83332009491 substrate binding site [chemical binding]; other site 83332009492 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 83332009493 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 83332009494 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 83332009495 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 83332009496 active site 83332009497 FMN binding site [chemical binding]; other site 83332009498 substrate binding site [chemical binding]; other site 83332009499 putative catalytic residue [active] 83332009500 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 83332009501 phosphate binding site [ion binding]; other site 83332009502 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 83332009503 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 83332009504 phosphopeptide binding site; other site 83332009505 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 83332009506 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 83332009507 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 83332009508 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 83332009509 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 83332009510 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 83332009511 G1 box; other site 83332009512 GTP/Mg2+ binding site [chemical binding]; other site 83332009513 G2 box; other site 83332009514 Switch I region; other site 83332009515 G3 box; other site 83332009516 Switch II region; other site 83332009517 G4 box; other site 83332009518 G5 box; other site 83332009519 Protein of unknown function (DUF742); Region: DUF742; pfam05331 83332009520 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 83332009521 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 83332009522 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 83332009523 ATP binding site [chemical binding]; other site 83332009524 Mg2+ binding site [ion binding]; other site 83332009525 G-X-G motif; other site 83332009526 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 83332009527 PE family; Region: PE; pfam00934 83332009528 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 83332009529 FMN binding site [chemical binding]; other site 83332009530 dimer interface [polypeptide binding]; other site 83332009531 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 83332009532 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 83332009533 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 83332009534 active site 83332009535 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 83332009536 generic binding surface II; other site 83332009537 generic binding surface I; other site 83332009538 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 83332009539 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 83332009540 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 83332009541 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 83332009542 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 83332009543 active site 83332009544 motif I; other site 83332009545 motif II; other site 83332009546 PE family; Region: PE; pfam00934 83332009547 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 83332009548 substrate binding site [chemical binding]; other site 83332009549 oxyanion hole (OAH) forming residues; other site 83332009550 trimer interface [polypeptide binding]; other site 83332009551 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 83332009552 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 83332009553 Amidase; Region: Amidase; pfam01425 83332009554 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 83332009555 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 83332009556 motif II; other site 83332009557 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 83332009558 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 83332009559 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 83332009560 TPP-binding site [chemical binding]; other site 83332009561 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 83332009562 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 83332009563 PYR/PP interface [polypeptide binding]; other site 83332009564 dimer interface [polypeptide binding]; other site 83332009565 TPP binding site [chemical binding]; other site 83332009566 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 83332009567 putative transposase OrfB; Reviewed; Region: PHA02517 83332009568 HTH-like domain; Region: HTH_21; pfam13276 83332009569 Integrase core domain; Region: rve; pfam00665 83332009570 Integrase core domain; Region: rve_3; pfam13683 83332009571 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 83332009572 Transposase; Region: HTH_Tnp_1; cl17663 83332009573 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 83332009574 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 83332009575 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 83332009576 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 83332009577 substrate binding pocket [chemical binding]; other site 83332009578 chain length determination region; other site 83332009579 substrate-Mg2+ binding site; other site 83332009580 catalytic residues [active] 83332009581 aspartate-rich region 1; other site 83332009582 active site lid residues [active] 83332009583 aspartate-rich region 2; other site 83332009584 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 83332009585 putative active site [active] 83332009586 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 83332009587 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 83332009588 Transposase domain (DUF772); Region: DUF772; pfam05598 83332009589 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 83332009590 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 83332009591 PE family; Region: PE; pfam00934 83332009592 enoyl-CoA hydratase; Region: PLN02864 83332009593 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 83332009594 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 83332009595 dimer interaction site [polypeptide binding]; other site 83332009596 substrate-binding tunnel; other site 83332009597 active site 83332009598 catalytic site [active] 83332009599 substrate binding site [chemical binding]; other site 83332009600 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 83332009601 short chain dehydrogenase; Provisional; Region: PRK07201 83332009602 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 83332009603 putative NAD(P) binding site [chemical binding]; other site 83332009604 active site 83332009605 putative substrate binding site [chemical binding]; other site 83332009606 classical (c) SDRs; Region: SDR_c; cd05233 83332009607 NAD(P) binding site [chemical binding]; other site 83332009608 active site 83332009609 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 83332009610 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332009611 S-adenosylmethionine binding site [chemical binding]; other site 83332009612 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 83332009613 active site 83332009614 DNA Polymerase Y-family; Region: PolY_like; cd03468 83332009615 DNA binding site [nucleotide binding] 83332009616 GMP synthase; Reviewed; Region: guaA; PRK00074 83332009617 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 83332009618 AMP/PPi binding site [chemical binding]; other site 83332009619 candidate oxyanion hole; other site 83332009620 catalytic triad [active] 83332009621 potential glutamine specificity residues [chemical binding]; other site 83332009622 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 83332009623 ATP Binding subdomain [chemical binding]; other site 83332009624 Ligand Binding sites [chemical binding]; other site 83332009625 Dimerization subdomain; other site 83332009626 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 83332009627 active site lid residues [active] 83332009628 substrate binding pocket [chemical binding]; other site 83332009629 catalytic residues [active] 83332009630 substrate-Mg2+ binding site; other site 83332009631 aspartate-rich region 1; other site 83332009632 aspartate-rich region 2; other site 83332009633 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 83332009634 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 83332009635 substrate binding pocket [chemical binding]; other site 83332009636 chain length determination region; other site 83332009637 substrate-Mg2+ binding site; other site 83332009638 catalytic residues [active] 83332009639 aspartate-rich region 1; other site 83332009640 active site lid residues [active] 83332009641 aspartate-rich region 2; other site 83332009642 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 83332009643 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 83332009644 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 83332009645 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 83332009646 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 83332009647 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 83332009648 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 83332009649 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 83332009650 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 83332009651 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 83332009652 inhibitor-cofactor binding pocket; inhibition site 83332009653 pyridoxal 5'-phosphate binding site [chemical binding]; other site 83332009654 catalytic residue [active] 83332009655 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 83332009656 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 83332009657 hypothetical protein; Provisional; Region: PRK07579 83332009658 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 83332009659 active site 83332009660 cosubstrate binding site; other site 83332009661 substrate binding site [chemical binding]; other site 83332009662 catalytic site [active] 83332009663 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332009664 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332009665 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 83332009666 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 83332009667 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 83332009668 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 83332009669 putative active site [active] 83332009670 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 83332009671 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 83332009672 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 83332009673 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 83332009674 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 83332009675 phosphate binding site [ion binding]; other site 83332009676 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 83332009677 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 83332009678 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 83332009679 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 83332009680 active site 83332009681 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 83332009682 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 83332009683 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 83332009684 DNA binding residues [nucleotide binding] 83332009685 Transcription factor WhiB; Region: Whib; pfam02467 83332009686 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 83332009687 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 83332009688 ring oligomerisation interface [polypeptide binding]; other site 83332009689 ATP/Mg binding site [chemical binding]; other site 83332009690 stacking interactions; other site 83332009691 hinge regions; other site 83332009692 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 83332009693 oligomerisation interface [polypeptide binding]; other site 83332009694 mobile loop; other site 83332009695 roof hairpin; other site 83332009696 UGMP family protein; Validated; Region: PRK09604 83332009697 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 83332009698 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 83332009699 Coenzyme A binding pocket [chemical binding]; other site 83332009700 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 83332009701 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 83332009702 alanine racemase; Reviewed; Region: alr; PRK00053 83332009703 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 83332009704 active site 83332009705 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 83332009706 dimer interface [polypeptide binding]; other site 83332009707 substrate binding site [chemical binding]; other site 83332009708 catalytic residues [active] 83332009709 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332009710 PPE family; Region: PPE; pfam00823 83332009711 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332009712 PPE family; Region: PPE; pfam00823 83332009713 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 83332009714 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 83332009715 Walker A motif; other site 83332009716 ATP binding site [chemical binding]; other site 83332009717 Walker B motif; other site 83332009718 arginine finger; other site 83332009719 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 83332009720 Integrase core domain; Region: rve; pfam00665 83332009721 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332009722 PPE family; Region: PPE; pfam00823 83332009723 Integrase core domain; Region: rve; pfam00665 83332009724 Integrase core domain; Region: rve_3; pfam13683 83332009725 Transposase, Mutator family; Region: Transposase_mut; pfam00872 83332009726 MULE transposase domain; Region: MULE; pfam10551 83332009727 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 83332009728 pyridoxal 5'-phosphate binding site [chemical binding]; other site 83332009729 catalytic residue [active] 83332009730 Uncharacterized conserved protein [Function unknown]; Region: COG0062 83332009731 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 83332009732 putative substrate binding site [chemical binding]; other site 83332009733 putative ATP binding site [chemical binding]; other site 83332009734 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 83332009735 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 83332009736 glutaminase active site [active] 83332009737 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 83332009738 dimer interface [polypeptide binding]; other site 83332009739 active site 83332009740 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 83332009741 dimer interface [polypeptide binding]; other site 83332009742 active site 83332009743 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 83332009744 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 83332009745 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 83332009746 active site 83332009747 substrate binding site [chemical binding]; other site 83332009748 metal binding site [ion binding]; metal-binding site 83332009749 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 83332009750 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 83332009751 23S rRNA interface [nucleotide binding]; other site 83332009752 L3 interface [polypeptide binding]; other site 83332009753 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 83332009754 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 83332009755 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 83332009756 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 83332009757 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 83332009758 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 83332009759 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 83332009760 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 83332009761 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 83332009762 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 83332009763 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 83332009764 active site 83332009765 catalytic residues [active] 83332009766 Protein of unknown function (DUF690); Region: DUF690; pfam05108 83332009767 Cutinase; Region: Cutinase; pfam01083 83332009768 Cutinase; Region: Cutinase; pfam01083 83332009769 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 83332009770 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 83332009771 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 83332009772 active site 83332009773 dimerization interface 3.5A [polypeptide binding]; other site 83332009774 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 83332009775 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 83332009776 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 83332009777 alphaNTD - beta interaction site [polypeptide binding]; other site 83332009778 alphaNTD homodimer interface [polypeptide binding]; other site 83332009779 alphaNTD - beta' interaction site [polypeptide binding]; other site 83332009780 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 83332009781 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 83332009782 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 83332009783 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 83332009784 RNA binding surface [nucleotide binding]; other site 83332009785 30S ribosomal protein S11; Validated; Region: PRK05309 83332009786 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 83332009787 30S ribosomal protein S13; Region: bact_S13; TIGR03631 83332009788 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 83332009789 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 83332009790 rRNA binding site [nucleotide binding]; other site 83332009791 predicted 30S ribosome binding site; other site 83332009792 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 83332009793 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 83332009794 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 83332009795 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 83332009796 NAD binding site [chemical binding]; other site 83332009797 substrate binding site [chemical binding]; other site 83332009798 homodimer interface [polypeptide binding]; other site 83332009799 active site 83332009800 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 83332009801 Domain of unknown function (DUF222); Region: DUF222; pfam02720 83332009802 Domain of unknown function (DUF222); Region: DUF222; pfam02720 83332009803 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 83332009804 active site 83332009805 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 83332009806 extended (e) SDRs; Region: SDR_e; cd08946 83332009807 NAD(P) binding site [chemical binding]; other site 83332009808 active site 83332009809 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 83332009810 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 83332009811 active site 83332009812 catalytic residues [active] 83332009813 metal binding site [ion binding]; metal-binding site 83332009814 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 83332009815 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 83332009816 PYR/PP interface [polypeptide binding]; other site 83332009817 dimer interface [polypeptide binding]; other site 83332009818 TPP binding site [chemical binding]; other site 83332009819 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 83332009820 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 83332009821 TPP-binding site [chemical binding]; other site 83332009822 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 83332009823 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 83332009824 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 83332009825 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 83332009826 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 83332009827 Transposase; Region: HTH_Tnp_1; cl17663 83332009828 putative transposase OrfB; Reviewed; Region: PHA02517 83332009829 HTH-like domain; Region: HTH_21; pfam13276 83332009830 Integrase core domain; Region: rve; pfam00665 83332009831 Integrase core domain; Region: rve_3; pfam13683 83332009832 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 83332009833 metabolite-proton symporter; Region: 2A0106; TIGR00883 83332009834 putative substrate translocation pore; other site 83332009835 PE family; Region: PE; pfam00934 83332009836 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332009837 PPE family; Region: PPE; pfam00823 83332009838 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 83332009839 patatin-related protein; Region: TIGR03607 83332009840 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 83332009841 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 83332009842 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 83332009843 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 83332009844 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 83332009845 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 83332009846 Transcriptional regulator [Transcription]; Region: LytR; COG1316 83332009847 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 83332009848 short chain dehydrogenase; Provisional; Region: PRK05875 83332009849 classical (c) SDRs; Region: SDR_c; cd05233 83332009850 NAD(P) binding site [chemical binding]; other site 83332009851 active site 83332009852 Predicted membrane protein [Function unknown]; Region: COG2259 83332009853 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 83332009854 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 83332009855 Predicted transcriptional regulators [Transcription]; Region: COG1695 83332009856 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 83332009857 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 83332009858 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 83332009859 active site 83332009860 homotetramer interface [polypeptide binding]; other site 83332009861 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 83332009862 mce related protein; Region: MCE; pfam02470 83332009863 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 83332009864 mce related protein; Region: MCE; pfam02470 83332009865 mce related protein; Region: MCE; pfam02470 83332009866 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 83332009867 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 83332009868 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 83332009869 mce related protein; Region: MCE; pfam02470 83332009870 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 83332009871 mce related protein; Region: MCE; pfam02470 83332009872 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 83332009873 mce related protein; Region: MCE; pfam02470 83332009874 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 83332009875 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 83332009876 Permease; Region: Permease; pfam02405 83332009877 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 83332009878 Permease; Region: Permease; pfam02405 83332009879 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 83332009880 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 83332009881 NAD(P) binding site [chemical binding]; other site 83332009882 active site 83332009883 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 83332009884 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 83332009885 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332009886 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 83332009887 FAD binding site [chemical binding]; other site 83332009888 substrate binding site [chemical binding]; other site 83332009889 catalytic base [active] 83332009890 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332009891 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 83332009892 active site 83332009893 acyl-CoA synthetase; Validated; Region: PRK07867 83332009894 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 83332009895 acyl-activating enzyme (AAE) consensus motif; other site 83332009896 putative AMP binding site [chemical binding]; other site 83332009897 putative active site [active] 83332009898 putative CoA binding site [chemical binding]; other site 83332009899 PE family; Region: PE; pfam00934 83332009900 PE family; Region: PE; pfam00934 83332009901 hypothetical protein; Validated; Region: PRK07586 83332009902 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 83332009903 PYR/PP interface [polypeptide binding]; other site 83332009904 dimer interface [polypeptide binding]; other site 83332009905 TPP binding site [chemical binding]; other site 83332009906 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 83332009907 TPP-binding site [chemical binding]; other site 83332009908 dimer interface [polypeptide binding]; other site 83332009909 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 83332009910 PE family; Region: PE; pfam00934 83332009911 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 83332009912 CoA binding site [chemical binding]; other site 83332009913 PE family; Region: PE; pfam00934 83332009914 acyl-CoA synthetase; Validated; Region: PRK07798 83332009915 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 83332009916 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 83332009917 acyl-activating enzyme (AAE) consensus motif; other site 83332009918 acyl-activating enzyme (AAE) consensus motif; other site 83332009919 putative AMP binding site [chemical binding]; other site 83332009920 putative active site [active] 83332009921 putative CoA binding site [chemical binding]; other site 83332009922 enoyl-CoA hydratase; Provisional; Region: PRK07799 83332009923 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 83332009924 substrate binding site [chemical binding]; other site 83332009925 oxyanion hole (OAH) forming residues; other site 83332009926 trimer interface [polypeptide binding]; other site 83332009927 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 83332009928 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 83332009929 Cytochrome P450; Region: p450; cl12078 83332009930 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 83332009931 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 83332009932 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 83332009933 DUF35 OB-fold domain; Region: DUF35; pfam01796 83332009934 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 83332009935 DUF35 OB-fold domain; Region: DUF35; pfam01796 83332009936 lipid-transfer protein; Provisional; Region: PRK07937 83332009937 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 83332009938 active site 83332009939 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 83332009940 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 83332009941 active site 83332009942 NHL repeat; Region: NHL; pfam01436 83332009943 Uncharacterized conserved protein [Function unknown]; Region: COG3391 83332009944 NHL repeat; Region: NHL; pfam01436 83332009945 NHL repeat; Region: NHL; pfam01436 83332009946 NHL repeat; Region: NHL; pfam01436 83332009947 NHL repeat; Region: NHL; pfam01436 83332009948 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 83332009949 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 83332009950 trimer interface [polypeptide binding]; other site 83332009951 putative metal binding site [ion binding]; other site 83332009952 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 83332009953 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 83332009954 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 83332009955 short chain dehydrogenase; Provisional; Region: PRK07890 83332009956 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 83332009957 NAD(P) binding site [chemical binding]; other site 83332009958 active site 83332009959 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332009960 PPE family; Region: PPE; pfam00823 83332009961 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 83332009962 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332009963 PPE family; Region: PPE; pfam00823 83332009964 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009965 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009966 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 83332009967 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 83332009968 active site 83332009969 catalytic residues [active] 83332009970 metal binding site [ion binding]; metal-binding site 83332009971 DmpG-like communication domain; Region: DmpG_comm; pfam07836 83332009972 acetaldehyde dehydrogenase; Validated; Region: PRK08300 83332009973 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 83332009974 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 83332009975 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971 83332009976 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 83332009977 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 83332009978 enoyl-CoA hydratase; Region: PLN02864 83332009979 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 83332009980 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 83332009981 dimer interaction site [polypeptide binding]; other site 83332009982 substrate-binding tunnel; other site 83332009983 active site 83332009984 catalytic site [active] 83332009985 substrate binding site [chemical binding]; other site 83332009986 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332009987 PPE family; Region: PPE; pfam00823 83332009988 PE-PPE domain; Region: PE-PPE; pfam08237 83332009989 lipid-transfer protein; Provisional; Region: PRK07855 83332009990 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 83332009991 active site 83332009992 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 83332009993 putative active site [active] 83332009994 putative catalytic site [active] 83332009995 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 83332009996 active site 83332009997 catalytic site [active] 83332009998 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 83332009999 DUF35 OB-fold domain; Region: DUF35; pfam01796 83332010000 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332010001 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 83332010002 active site 83332010003 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332010004 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 83332010005 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 83332010006 active site 83332010007 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 83332010008 Cytochrome P450; Region: p450; cl12078 83332010009 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 83332010010 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 83332010011 dimer interface [polypeptide binding]; other site 83332010012 active site 83332010013 Domain of unknown function (DUF385); Region: DUF385; pfam04075 83332010014 short chain dehydrogenase; Provisional; Region: PRK07791 83332010015 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 83332010016 homodimer interface [polypeptide binding]; other site 83332010017 NAD binding site [chemical binding]; other site 83332010018 active site 83332010019 short chain dehydrogenase; Provisional; Region: PRK07856 83332010020 classical (c) SDRs; Region: SDR_c; cd05233 83332010021 NAD(P) binding site [chemical binding]; other site 83332010022 active site 83332010023 enoyl-CoA hydratase; Provisional; Region: PRK06495 83332010024 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 83332010025 substrate binding site [chemical binding]; other site 83332010026 oxyanion hole (OAH) forming residues; other site 83332010027 trimer interface [polypeptide binding]; other site 83332010028 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 83332010029 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057 83332010030 Nitronate monooxygenase; Region: NMO; pfam03060 83332010031 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 83332010032 FMN binding site [chemical binding]; other site 83332010033 substrate binding site [chemical binding]; other site 83332010034 putative catalytic residue [active] 83332010035 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 83332010036 Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514 83332010037 putative di-iron ligands [ion binding]; other site 83332010038 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 83332010039 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 83332010040 FAD binding pocket [chemical binding]; other site 83332010041 FAD binding motif [chemical binding]; other site 83332010042 phosphate binding motif [ion binding]; other site 83332010043 beta-alpha-beta structure motif; other site 83332010044 NAD(p) ribose binding residues [chemical binding]; other site 83332010045 NAD binding pocket [chemical binding]; other site 83332010046 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 83332010047 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 83332010048 catalytic loop [active] 83332010049 iron binding site [ion binding]; other site 83332010050 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 83332010051 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 83332010052 putative active site [active] 83332010053 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 83332010054 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 83332010055 dimer interface [polypeptide binding]; other site 83332010056 active site 83332010057 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332010058 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332010059 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332010060 PPE family; Region: PPE; pfam00823 83332010061 short chain dehydrogenase; Provisional; Region: PRK07831 83332010062 classical (c) SDRs; Region: SDR_c; cd05233 83332010063 NAD(P) binding site [chemical binding]; other site 83332010064 active site 83332010065 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332010066 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 83332010067 active site 83332010068 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 83332010069 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 83332010070 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 83332010071 acyl-activating enzyme (AAE) consensus motif; other site 83332010072 putative AMP binding site [chemical binding]; other site 83332010073 putative active site [active] 83332010074 putative CoA binding site [chemical binding]; other site 83332010075 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332010076 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 83332010077 active site 83332010078 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332010079 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 83332010080 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 83332010081 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332010082 active site 83332010083 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332010084 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 83332010085 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 83332010086 active site 83332010087 aspartate aminotransferase; Provisional; Region: PRK05764 83332010088 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 83332010089 pyridoxal 5'-phosphate binding site [chemical binding]; other site 83332010090 homodimer interface [polypeptide binding]; other site 83332010091 catalytic residue [active] 83332010092 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 83332010093 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 83332010094 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 83332010095 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 83332010096 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 83332010097 active site 83332010098 Fe binding site [ion binding]; other site 83332010099 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 83332010100 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332010101 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 83332010102 Flavin binding site [chemical binding]; other site 83332010103 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 83332010104 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 83332010105 FAD binding pocket [chemical binding]; other site 83332010106 FAD binding motif [chemical binding]; other site 83332010107 phosphate binding motif [ion binding]; other site 83332010108 beta-alpha-beta structure motif; other site 83332010109 NAD(p) ribose binding residues [chemical binding]; other site 83332010110 NAD binding pocket [chemical binding]; other site 83332010111 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 83332010112 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 83332010113 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 83332010114 catalytic loop [active] 83332010115 iron binding site [ion binding]; other site 83332010116 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332010117 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 83332010118 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 83332010119 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332010120 active site 83332010121 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332010122 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332010123 Transcriptional regulators [Transcription]; Region: PurR; COG1609 83332010124 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 83332010125 DNA binding site [nucleotide binding] 83332010126 domain linker motif; other site 83332010127 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 83332010128 putative dimerization interface [polypeptide binding]; other site 83332010129 putative ligand binding site [chemical binding]; other site 83332010130 PknH-like extracellular domain; Region: PknH_C; pfam14032 83332010131 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 83332010132 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 83332010133 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 83332010134 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 83332010135 transmembrane helices; other site 83332010136 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 83332010137 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 83332010138 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 83332010139 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 83332010140 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 83332010141 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 83332010142 active site 83332010143 HIGH motif; other site 83332010144 nucleotide binding site [chemical binding]; other site 83332010145 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 83332010146 KMSKS motif; other site 83332010147 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 83332010148 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 83332010149 homotrimer interaction site [polypeptide binding]; other site 83332010150 zinc binding site [ion binding]; other site 83332010151 CDP-binding sites; other site 83332010152 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 83332010153 substrate binding site; other site 83332010154 dimer interface; other site 83332010155 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 83332010156 DNA repair protein RadA; Provisional; Region: PRK11823 83332010157 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 83332010158 Walker A motif/ATP binding site; other site 83332010159 ATP binding site [chemical binding]; other site 83332010160 Walker B motif; other site 83332010161 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 83332010162 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 83332010163 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 83332010164 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 83332010165 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 83332010166 active site clefts [active] 83332010167 zinc binding site [ion binding]; other site 83332010168 dimer interface [polypeptide binding]; other site 83332010169 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 83332010170 endonuclease III; Region: ENDO3c; smart00478 83332010171 minor groove reading motif; other site 83332010172 helix-hairpin-helix signature motif; other site 83332010173 substrate binding pocket [chemical binding]; other site 83332010174 active site 83332010175 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 83332010176 PE family; Region: PE; pfam00934 83332010177 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 83332010178 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 83332010179 catalytic site [active] 83332010180 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 83332010181 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 83332010182 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 83332010183 Ami_2 domain; Region: Ami_2; smart00644 83332010184 amidase catalytic site [active] 83332010185 Zn binding residues [ion binding]; other site 83332010186 substrate binding site [chemical binding]; other site 83332010187 PE family; Region: PE; pfam00934 83332010188 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 83332010189 Clp amino terminal domain; Region: Clp_N; pfam02861 83332010190 Clp amino terminal domain; Region: Clp_N; pfam02861 83332010191 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 83332010192 Walker A motif; other site 83332010193 ATP binding site [chemical binding]; other site 83332010194 Walker B motif; other site 83332010195 arginine finger; other site 83332010196 UvrB/uvrC motif; Region: UVR; pfam02151 83332010197 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 83332010198 Walker A motif; other site 83332010199 ATP binding site [chemical binding]; other site 83332010200 Walker B motif; other site 83332010201 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 83332010202 Lsr2; Region: Lsr2; pfam11774 83332010203 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 83332010204 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 83332010205 dimer interface [polypeptide binding]; other site 83332010206 putative anticodon binding site; other site 83332010207 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 83332010208 motif 1; other site 83332010209 dimer interface [polypeptide binding]; other site 83332010210 active site 83332010211 motif 2; other site 83332010212 motif 3; other site 83332010213 pantothenate kinase; Reviewed; Region: PRK13318 83332010214 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 83332010215 tetramerization interface [polypeptide binding]; other site 83332010216 active site 83332010217 Pantoate-beta-alanine ligase; Region: PanC; cd00560 83332010218 pantoate--beta-alanine ligase; Region: panC; TIGR00018 83332010219 active site 83332010220 ATP-binding site [chemical binding]; other site 83332010221 pantoate-binding site; other site 83332010222 HXXH motif; other site 83332010223 Rossmann-like domain; Region: Rossmann-like; pfam10727 83332010224 Uncharacterized conserved protein [Function unknown]; Region: COG5495 83332010225 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 83332010226 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 83332010227 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 83332010228 catalytic center binding site [active] 83332010229 ATP binding site [chemical binding]; other site 83332010230 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 83332010231 homooctamer interface [polypeptide binding]; other site 83332010232 active site 83332010233 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 83332010234 dihydropteroate synthase; Region: DHPS; TIGR01496 83332010235 substrate binding pocket [chemical binding]; other site 83332010236 dimer interface [polypeptide binding]; other site 83332010237 inhibitor binding site; inhibition site 83332010238 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 83332010239 homodecamer interface [polypeptide binding]; other site 83332010240 GTP cyclohydrolase I; Provisional; Region: PLN03044 83332010241 active site 83332010242 putative catalytic site residues [active] 83332010243 zinc binding site [ion binding]; other site 83332010244 GTP-CH-I/GFRP interaction surface; other site 83332010245 FtsH Extracellular; Region: FtsH_ext; pfam06480 83332010246 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 83332010247 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 83332010248 Walker A motif; other site 83332010249 ATP binding site [chemical binding]; other site 83332010250 Walker B motif; other site 83332010251 arginine finger; other site 83332010252 Peptidase family M41; Region: Peptidase_M41; pfam01434 83332010253 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 83332010254 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 83332010255 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 83332010256 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 83332010257 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 83332010258 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 83332010259 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 83332010260 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 83332010261 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332010262 PPE family; Region: PPE; pfam00823 83332010263 PE family; Region: PE; pfam00934 83332010264 Uncharacterized conserved protein [Function unknown]; Region: COG2968 83332010265 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 83332010266 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 83332010267 active site 83332010268 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 83332010269 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 83332010270 Ligand Binding Site [chemical binding]; other site 83332010271 Uncharacterized conserved protein [Function unknown]; Region: COG5282 83332010272 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 83332010273 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113 83332010274 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 83332010275 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 83332010276 dimer interface [polypeptide binding]; other site 83332010277 substrate binding site [chemical binding]; other site 83332010278 metal binding sites [ion binding]; metal-binding site 83332010279 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2899 83332010280 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 83332010281 Ligand binding site; other site 83332010282 Putative Catalytic site; other site 83332010283 DXD motif; other site 83332010284 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 83332010285 Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5285 83332010286 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 83332010287 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 83332010288 NAD(P) binding site [chemical binding]; other site 83332010289 active site 83332010290 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 83332010291 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 83332010292 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 83332010293 transposase; Provisional; Region: PRK06526 83332010294 IstB-like ATP binding protein; Region: IstB_IS21; pfam01695 83332010295 Walker B motif; other site 83332010296 Transposase, Mutator family; Region: Transposase_mut; pfam00872 83332010297 MULE transposase domain; Region: MULE; pfam10551 83332010298 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 83332010299 Fic/DOC family; Region: Fic; cl00960 83332010300 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 83332010301 DNA polymerase III subunit delta'; Validated; Region: PRK07940 83332010302 DNA polymerase III subunit delta'; Validated; Region: PRK08485 83332010303 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 83332010304 dimerization interface [polypeptide binding]; other site 83332010305 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 83332010306 cyclase homology domain; Region: CHD; cd07302 83332010307 nucleotidyl binding site; other site 83332010308 metal binding site [ion binding]; metal-binding site 83332010309 dimer interface [polypeptide binding]; other site 83332010310 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 83332010311 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 83332010312 active site 83332010313 interdomain interaction site; other site 83332010314 putative metal-binding site [ion binding]; other site 83332010315 nucleotide binding site [chemical binding]; other site 83332010316 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 83332010317 domain I; other site 83332010318 phosphate binding site [ion binding]; other site 83332010319 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 83332010320 domain II; other site 83332010321 domain III; other site 83332010322 nucleotide binding site [chemical binding]; other site 83332010323 DNA binding groove [nucleotide binding] 83332010324 catalytic site [active] 83332010325 domain IV; other site 83332010326 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 83332010327 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 83332010328 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 83332010329 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 83332010330 DNA-binding site [nucleotide binding]; DNA binding site 83332010331 RNA-binding motif; other site 83332010332 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 83332010333 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 83332010334 ATP binding site [chemical binding]; other site 83332010335 putative Mg++ binding site [ion binding]; other site 83332010336 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 83332010337 nucleotide binding region [chemical binding]; other site 83332010338 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 83332010339 PE family; Region: PE; pfam00934 83332010340 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 83332010341 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 83332010342 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 83332010343 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 83332010344 Walker A motif; other site 83332010345 ATP binding site [chemical binding]; other site 83332010346 Walker B motif; other site 83332010347 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 83332010348 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 83332010349 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 83332010350 motif II; other site 83332010351 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 83332010352 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 83332010353 Walker A/P-loop; other site 83332010354 ATP binding site [chemical binding]; other site 83332010355 Q-loop/lid; other site 83332010356 ABC transporter signature motif; other site 83332010357 Walker B; other site 83332010358 D-loop; other site 83332010359 H-loop/switch region; other site 83332010360 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 83332010361 Walker A/P-loop; other site 83332010362 ATP binding site [chemical binding]; other site 83332010363 Q-loop/lid; other site 83332010364 ABC transporter signature motif; other site 83332010365 Walker B; other site 83332010366 D-loop; other site 83332010367 H-loop/switch region; other site 83332010368 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 83332010369 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 83332010370 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 83332010371 ABC-ATPase subunit interface; other site 83332010372 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 83332010373 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 83332010374 dimer interface [polypeptide binding]; other site 83332010375 conserved gate region; other site 83332010376 ABC-ATPase subunit interface; other site 83332010377 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 83332010378 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 83332010379 acetyl-CoA synthetase; Provisional; Region: PRK00174 83332010380 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 83332010381 active site 83332010382 CoA binding site [chemical binding]; other site 83332010383 acyl-activating enzyme (AAE) consensus motif; other site 83332010384 AMP binding site [chemical binding]; other site 83332010385 acetate binding site [chemical binding]; other site 83332010386 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 83332010387 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 83332010388 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 83332010389 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 83332010390 putative active site [active] 83332010391 putative CoA binding site [chemical binding]; other site 83332010392 nudix motif; other site 83332010393 metal binding site [ion binding]; metal-binding site 83332010394 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 83332010395 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 83332010396 catalytic residues [active] 83332010397 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 83332010398 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 83332010399 minor groove reading motif; other site 83332010400 helix-hairpin-helix signature motif; other site 83332010401 substrate binding pocket [chemical binding]; other site 83332010402 active site 83332010403 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 83332010404 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 83332010405 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 83332010406 ligand binding site [chemical binding]; other site 83332010407 flexible hinge region; other site 83332010408 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 83332010409 putative switch regulator; other site 83332010410 non-specific DNA interactions [nucleotide binding]; other site 83332010411 DNA binding site [nucleotide binding] 83332010412 sequence specific DNA binding site [nucleotide binding]; other site 83332010413 putative cAMP binding site [chemical binding]; other site 83332010414 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 83332010415 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 83332010416 homotrimer interaction site [polypeptide binding]; other site 83332010417 putative active site [active] 83332010418 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 83332010419 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 83332010420 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 83332010421 P loop; other site 83332010422 Nucleotide binding site [chemical binding]; other site 83332010423 DTAP/Switch II; other site 83332010424 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 83332010425 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 83332010426 DTAP/Switch II; other site 83332010427 Switch I; other site 83332010428 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 83332010429 Transcription factor WhiB; Region: Whib; pfam02467 83332010430 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 83332010431 Transglycosylase; Region: Transgly; pfam00912 83332010432 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 83332010433 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 83332010434 phosphodiesterase YaeI; Provisional; Region: PRK11340 83332010435 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 83332010436 putative active site [active] 83332010437 putative metal binding site [ion binding]; other site 83332010438 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 83332010439 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 83332010440 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 83332010441 catalytic residue [active] 83332010442 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 83332010443 Cytochrome P450; Region: p450; cl12078 83332010444 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 83332010445 anti sigma factor interaction site; other site 83332010446 regulatory phosphorylation site [posttranslational modification]; other site 83332010447 Uncharacterized conserved protein [Function unknown]; Region: COG1610 83332010448 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 83332010449 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 83332010450 MoxR-like ATPases [General function prediction only]; Region: COG0714 83332010451 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 83332010452 Walker A motif; other site 83332010453 ATP binding site [chemical binding]; other site 83332010454 Walker B motif; other site 83332010455 arginine finger; other site 83332010456 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 83332010457 Protein of unknown function DUF58; Region: DUF58; pfam01882 83332010458 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 83332010459 Predicted membrane protein/domain [Function unknown]; Region: COG1714 83332010460 glycerol kinase; Provisional; Region: glpK; PRK00047 83332010461 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 83332010462 nucleotide binding site [chemical binding]; other site 83332010463 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 83332010464 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 83332010465 Methyltransferase domain; Region: Methyltransf_23; pfam13489 83332010466 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332010467 S-adenosylmethionine binding site [chemical binding]; other site 83332010468 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 83332010469 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 83332010470 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 83332010471 catalytic residue [active] 83332010472 Uncharacterized conserved protein [Function unknown]; Region: COG4301 83332010473 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 83332010474 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 83332010475 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 83332010476 putative active site [active] 83332010477 putative dimer interface [polypeptide binding]; other site 83332010478 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 83332010479 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 83332010480 Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG3572 83332010481 PknH-like extracellular domain; Region: PknH_C; pfam14032 83332010482 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 83332010483 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 83332010484 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 83332010485 aspartate kinase; Reviewed; Region: PRK06635 83332010486 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 83332010487 putative nucleotide binding site [chemical binding]; other site 83332010488 putative catalytic residues [active] 83332010489 putative Mg ion binding site [ion binding]; other site 83332010490 putative aspartate binding site [chemical binding]; other site 83332010491 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 83332010492 putative allosteric regulatory site; other site 83332010493 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 83332010494 putative allosteric regulatory residue; other site 83332010495 2-isopropylmalate synthase; Validated; Region: PRK03739 83332010496 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 83332010497 active site 83332010498 catalytic residues [active] 83332010499 metal binding site [ion binding]; metal-binding site 83332010500 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 83332010501 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 83332010502 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 83332010503 active site 83332010504 catalytic site [active] 83332010505 substrate binding site [chemical binding]; other site 83332010506 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 83332010507 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 83332010508 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 83332010509 catalytic triad [active] 83332010510 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 83332010511 putative active site [active] 83332010512 recombination protein RecR; Reviewed; Region: recR; PRK00076 83332010513 RecR protein; Region: RecR; pfam02132 83332010514 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 83332010515 putative active site [active] 83332010516 putative metal-binding site [ion binding]; other site 83332010517 tetramer interface [polypeptide binding]; other site 83332010518 hypothetical protein; Validated; Region: PRK00153 83332010519 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 83332010520 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 83332010521 active site 83332010522 metal binding site [ion binding]; metal-binding site 83332010523 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 83332010524 hydrophobic ligand binding site; other site 83332010525 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 83332010526 FAD binding domain; Region: FAD_binding_4; pfam01565 83332010527 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 83332010528 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332010529 S-adenosylmethionine binding site [chemical binding]; other site 83332010530 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14952 83332010531 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 83332010532 Walker A motif; other site 83332010533 ATP binding site [chemical binding]; other site 83332010534 Walker B motif; other site 83332010535 arginine finger; other site 83332010536 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 83332010537 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 83332010538 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 83332010539 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 83332010540 catalytic residue [active] 83332010541 Cutinase; Region: Cutinase; pfam01083 83332010542 Cutinase; Region: Cutinase; pfam01083 83332010543 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 83332010544 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 83332010545 NAD(P) binding site [chemical binding]; other site 83332010546 active site 83332010547 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 83332010548 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 83332010549 putative NAD(P) binding site [chemical binding]; other site 83332010550 catalytic Zn binding site [ion binding]; other site 83332010551 Uncharacterized conserved protein [Function unknown]; Region: COG3349 83332010552 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 83332010553 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 83332010554 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 83332010555 putative substrate translocation pore; other site 83332010556 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 83332010557 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 83332010558 ligand binding site [chemical binding]; other site 83332010559 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 83332010560 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 83332010561 active site 83332010562 nucleophile elbow; other site 83332010563 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 83332010564 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 83332010565 FeS/SAM binding site; other site 83332010566 Methyltransferase domain; Region: Methyltransf_31; pfam13847 83332010567 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332010568 S-adenosylmethionine binding site [chemical binding]; other site 83332010569 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 83332010570 nucleotide binding site [chemical binding]; other site 83332010571 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 83332010572 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 83332010573 active site 83332010574 DNA binding site [nucleotide binding] 83332010575 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 83332010576 DNA binding site [nucleotide binding] 83332010577 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4402 83332010578 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_5; cd04662 83332010579 nudix motif; other site 83332010580 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 83332010581 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 83332010582 Uncharacterized conserved protein [Function unknown]; Region: COG1839 83332010583 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 83332010584 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 83332010585 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 83332010586 Uncharacterized conserved protein [Function unknown]; Region: COG2966 83332010587 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 83332010588 Uncharacterized conserved protein [Function unknown]; Region: COG3610 83332010589 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332010590 PPE family; Region: PPE; pfam00823 83332010591 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332010592 PPE family; Region: PPE; pfam00823 83332010593 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 83332010594 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 83332010595 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 83332010596 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 83332010597 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 83332010598 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 83332010599 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 83332010600 Soluble P-type ATPase [General function prediction only]; Region: COG4087 83332010601 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 83332010602 dimerization interface [polypeptide binding]; other site 83332010603 putative DNA binding site [nucleotide binding]; other site 83332010604 putative Zn2+ binding site [ion binding]; other site 83332010605 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3651 83332010606 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 83332010607 PIN domain; Region: PIN_3; pfam13470 83332010608 DNA binding domain, excisionase family; Region: excise; TIGR01764 83332010609 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 83332010610 active site 83332010611 Int/Topo IB signature motif; other site 83332010612 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 83332010613 nucleoside/Zn binding site; other site 83332010614 dimer interface [polypeptide binding]; other site 83332010615 catalytic motif [active] 83332010616 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 83332010617 prephenate dehydrogenase; Validated; Region: PRK06545 83332010618 prephenate dehydrogenase; Validated; Region: PRK08507 83332010619 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3554 83332010620 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 83332010621 ABC-ATPase subunit interface; other site 83332010622 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 83332010623 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 83332010624 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 83332010625 Walker A/P-loop; other site 83332010626 ATP binding site [chemical binding]; other site 83332010627 Q-loop/lid; other site 83332010628 ABC transporter signature motif; other site 83332010629 Walker B; other site 83332010630 D-loop; other site 83332010631 H-loop/switch region; other site 83332010632 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 83332010633 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 83332010634 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 83332010635 putative active site [active] 83332010636 putative substrate binding site [chemical binding]; other site 83332010637 ATP binding site [chemical binding]; other site 83332010638 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 83332010639 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 83332010640 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 83332010641 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 83332010642 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 83332010643 dimerization interface [polypeptide binding]; other site 83332010644 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 83332010645 dimer interface [polypeptide binding]; other site 83332010646 phosphorylation site [posttranslational modification] 83332010647 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 83332010648 ATP binding site [chemical binding]; other site 83332010649 Mg2+ binding site [ion binding]; other site 83332010650 G-X-G motif; other site 83332010651 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 83332010652 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 83332010653 active site 83332010654 phosphorylation site [posttranslational modification] 83332010655 intermolecular recognition site; other site 83332010656 dimerization interface [polypeptide binding]; other site 83332010657 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 83332010658 DNA binding site [nucleotide binding] 83332010659 Photosystem II reaction centre W protein (PsbW); Region: PsbW; cl06243 83332010660 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 83332010661 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 83332010662 SnoaL-like domain; Region: SnoaL_2; pfam12680 83332010663 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 83332010664 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 83332010665 pyridoxal 5'-phosphate binding site [chemical binding]; other site 83332010666 homodimer interface [polypeptide binding]; other site 83332010667 catalytic residue [active] 83332010668 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 83332010669 TIGR03086 family protein; Region: TIGR03086 83332010670 enoyl-CoA hydratase; Provisional; Region: PRK06142 83332010671 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 83332010672 substrate binding site [chemical binding]; other site 83332010673 oxyanion hole (OAH) forming residues; other site 83332010674 trimer interface [polypeptide binding]; other site 83332010675 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 83332010676 Beta-lactamase; Region: Beta-lactamase; pfam00144 83332010677 Domain of unknown function (DUF222); Region: DUF222; pfam02720 83332010678 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 83332010679 active site 83332010680 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 83332010681 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 83332010682 NAD(P) binding site [chemical binding]; other site 83332010683 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 83332010684 cysteine desulfurase family protein, VC1184 subfamily; Region: am_tr_V_VC1184; TIGR01976 83332010685 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 83332010686 catalytic residue [active] 83332010687 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 83332010688 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 83332010689 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 83332010690 Walker A/P-loop; other site 83332010691 ATP binding site [chemical binding]; other site 83332010692 Q-loop/lid; other site 83332010693 ABC transporter signature motif; other site 83332010694 Walker B; other site 83332010695 D-loop; other site 83332010696 H-loop/switch region; other site 83332010697 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 83332010698 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 83332010699 active site 83332010700 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 83332010701 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 83332010702 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 83332010703 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 83332010704 NAD binding site [chemical binding]; other site 83332010705 substrate binding site [chemical binding]; other site 83332010706 active site 83332010707 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 83332010708 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 83332010709 active site 83332010710 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 83332010711 Peptidase family M23; Region: Peptidase_M23; pfam01551 83332010712 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 83332010713 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 83332010714 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05892 83332010715 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 83332010716 Predicted membrane protein [Function unknown]; Region: COG2246 83332010717 GtrA-like protein; Region: GtrA; pfam04138 83332010718 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 83332010719 FAD binding domain; Region: FAD_binding_4; pfam01565 83332010720 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 83332010721 short chain dehydrogenase; Provisional; Region: PRK07904 83332010722 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 83332010723 NAD(P) binding site [chemical binding]; other site 83332010724 active site 83332010725 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 83332010726 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 83332010727 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 83332010728 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 83332010729 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 83332010730 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 83332010731 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 83332010732 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332010733 FAD binding site [chemical binding]; other site 83332010734 substrate binding site [chemical binding]; other site 83332010735 catalytic residues [active] 83332010736 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 83332010737 Transposase; Region: DDE_Tnp_ISL3; pfam01610 83332010738 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 83332010739 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 83332010740 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 83332010741 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 83332010742 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 83332010743 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 83332010744 active site 83332010745 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 83332010746 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 83332010747 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 83332010748 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 83332010749 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 83332010750 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 83332010751 acyl-activating enzyme (AAE) consensus motif; other site 83332010752 active site 83332010753 Cutinase; Region: Cutinase; pfam01083 83332010754 Predicted esterase [General function prediction only]; Region: COG0627 83332010755 Putative esterase; Region: Esterase; pfam00756 83332010756 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 83332010757 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 83332010758 active site 83332010759 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 83332010760 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 83332010761 active site 83332010762 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 83332010763 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 83332010764 UDP-galactopyranose mutase; Region: GLF; pfam03275 83332010765 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 83332010766 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 83332010767 amidase catalytic site [active] 83332010768 Zn binding residues [ion binding]; other site 83332010769 substrate binding site [chemical binding]; other site 83332010770 LGFP repeat; Region: LGFP; pfam08310 83332010771 PE family; Region: PE; pfam00934 83332010772 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 83332010773 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 83332010774 active site 83332010775 motif I; other site 83332010776 motif II; other site 83332010777 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 83332010778 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 83332010779 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 83332010780 putative acyl-acceptor binding pocket; other site 83332010781 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 83332010782 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 83332010783 putative acyl-acceptor binding pocket; other site 83332010784 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 83332010785 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 83332010786 putative acyl-acceptor binding pocket; other site 83332010787 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 83332010788 Phosphotransferase enzyme family; Region: APH; pfam01636 83332010789 active site 83332010790 ATP binding site [chemical binding]; other site 83332010791 antibiotic binding site [chemical binding]; other site 83332010792 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 83332010793 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 83332010794 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 83332010795 iron-sulfur cluster [ion binding]; other site 83332010796 [2Fe-2S] cluster binding site [ion binding]; other site 83332010797 Condensation domain; Region: Condensation; pfam00668 83332010798 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 83332010799 PE-PPE domain; Region: PE-PPE; pfam08237 83332010800 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 83332010801 Condensation domain; Region: Condensation; pfam00668 83332010802 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 83332010803 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 83332010804 active site 83332010805 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 83332010806 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 83332010807 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 83332010808 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 83332010809 Enoylreductase; Region: PKS_ER; smart00829 83332010810 NAD(P) binding site [chemical binding]; other site 83332010811 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 83332010812 KR domain; Region: KR; pfam08659 83332010813 putative NADP binding site [chemical binding]; other site 83332010814 active site 83332010815 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 83332010816 acyl-CoA synthetase; Validated; Region: PRK05850 83332010817 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 83332010818 acyl-activating enzyme (AAE) consensus motif; other site 83332010819 active site 83332010820 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 83332010821 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 83332010822 Probable transposase; Region: OrfB_IS605; pfam01385 83332010823 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 83332010824 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 83332010825 catalytic residues [active] 83332010826 catalytic nucleophile [active] 83332010827 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 83332010828 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 83332010829 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 83332010830 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332010831 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 83332010832 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332010833 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 83332010834 Cupin domain; Region: Cupin_2; cl17218 83332010835 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 83332010836 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 83332010837 seryl-tRNA synthetase; Provisional; Region: PRK05431 83332010838 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 83332010839 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 83332010840 dimer interface [polypeptide binding]; other site 83332010841 active site 83332010842 motif 1; other site 83332010843 motif 2; other site 83332010844 motif 3; other site 83332010845 Septum formation; Region: Septum_form; pfam13845 83332010846 Septum formation; Region: Septum_form; pfam13845 83332010847 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 83332010848 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 83332010849 catalytic core [active] 83332010850 prephenate dehydratase; Provisional; Region: PRK11898 83332010851 Prephenate dehydratase; Region: PDT; pfam00800 83332010852 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 83332010853 putative L-Phe binding site [chemical binding]; other site 83332010854 Transcriptional regulator [Transcription]; Region: LytR; COG1316 83332010855 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 83332010856 Ferritin-like domain; Region: Ferritin; pfam00210 83332010857 ferroxidase diiron center [ion binding]; other site 83332010858 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 83332010859 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 83332010860 putative active site [active] 83332010861 catalytic site [active] 83332010862 putative metal binding site [ion binding]; other site 83332010863 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 83332010864 Transposase; Region: DEDD_Tnp_IS110; pfam01548 83332010865 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 83332010866 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 83332010867 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 83332010868 Predicted membrane protein [Function unknown]; Region: COG2119 83332010869 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 83332010870 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 83332010871 Fimbrial protein; Region: Fimbrial; cl01416 83332010872 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 83332010873 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 83332010874 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 83332010875 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332010876 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332010877 hypothetical protein; Provisional; Region: PRK07945 83332010878 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 83332010879 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 83332010880 active site 83332010881 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 83332010882 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 83332010883 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 83332010884 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 83332010885 active site 83332010886 dimer interface [polypeptide binding]; other site 83332010887 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 83332010888 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 83332010889 active site 83332010890 FMN binding site [chemical binding]; other site 83332010891 substrate binding site [chemical binding]; other site 83332010892 3Fe-4S cluster binding site [ion binding]; other site 83332010893 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 83332010894 domain interface; other site 83332010895 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 83332010896 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 83332010897 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 83332010898 EspG family; Region: ESX-1_EspG; pfam14011 83332010899 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 83332010900 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 83332010901 Walker A motif; other site 83332010902 ATP binding site [chemical binding]; other site 83332010903 Walker B motif; other site 83332010904 arginine finger; other site 83332010905 Protein of unknown function (DUF690); Region: DUF690; pfam05108 83332010906 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 83332010907 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 83332010908 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 83332010909 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 83332010910 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 83332010911 PE family; Region: PE; pfam00934 83332010912 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332010913 PPE family; Region: PPE; pfam00823 83332010914 Proteins of 100 residues with WXG; Region: WXG100; cl02005 83332010915 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 83332010916 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 83332010917 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 83332010918 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 83332010919 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 83332010920 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 83332010921 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 83332010922 active site 83332010923 catalytic residues [active] 83332010924 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 83332010925 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 83332010926 Walker A motif; other site 83332010927 ATP binding site [chemical binding]; other site 83332010928 Walker B motif; other site 83332010929 arginine finger; other site 83332010930 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 83332010931 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 83332010932 catalytic residues [active] 83332010933 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 83332010934 active site 83332010935 catalytic residues [active] 83332010936 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 83332010937 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 83332010938 EspG family; Region: ESX-1_EspG; pfam14011 83332010939 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 83332010940 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 83332010941 PPE family; Region: PPE; pfam00823 83332010942 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 83332010943 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 83332010944 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 83332010945 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 83332010946 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 83332010947 Protein of unknown function (DUF690); Region: DUF690; pfam05108 83332010948 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 83332010949 N-acetyl-D-glucosamine binding site [chemical binding]; other site 83332010950 catalytic residue [active] 83332010951 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 83332010952 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 83332010953 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 83332010954 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 83332010955 active site 83332010956 NTP binding site [chemical binding]; other site 83332010957 metal binding triad [ion binding]; metal-binding site 83332010958 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 83332010959 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 83332010960 Zn2+ binding site [ion binding]; other site 83332010961 Mg2+ binding site [ion binding]; other site 83332010962 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 83332010963 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 83332010964 active site 83332010965 Ap6A binding site [chemical binding]; other site 83332010966 nudix motif; other site 83332010967 metal binding site [ion binding]; metal-binding site 83332010968 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 83332010969 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 83332010970 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 83332010971 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 83332010972 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 83332010973 DNA binding residues [nucleotide binding] 83332010974 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 83332010975 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 83332010976 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 83332010977 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 83332010978 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 83332010979 catalytic residues [active] 83332010980 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 83332010981 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 83332010982 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 83332010983 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 83332010984 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 83332010985 active site 83332010986 metal binding site [ion binding]; metal-binding site 83332010987 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 83332010988 ParB-like nuclease domain; Region: ParB; smart00470 83332010989 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 83332010990 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 83332010991 P-loop; other site 83332010992 Magnesium ion binding site [ion binding]; other site 83332010993 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 83332010994 Magnesium ion binding site [ion binding]; other site 83332010995 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 83332010996 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 83332010997 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 83332010998 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 83332010999 G-X-X-G motif; other site 83332011000 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 83332011001 RxxxH motif; other site 83332011002 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 83332011003 Uncharacterized conserved protein [Function unknown]; Region: COG0759 83332011004 ribonuclease P; Reviewed; Region: rnpA; PRK00588 83332011005 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399