-- dump date 20140619_154836 -- class Genbank::misc_feature -- table misc_feature_note -- id note 395095000001 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 395095000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395095000003 Walker A motif; other site 395095000004 ATP binding site [chemical binding]; other site 395095000005 Walker B motif; other site 395095000006 arginine finger; other site 395095000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 395095000008 DnaA box-binding interface [nucleotide binding]; other site 395095000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 395095000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 395095000011 putative DNA binding surface [nucleotide binding]; other site 395095000012 dimer interface [polypeptide binding]; other site 395095000013 beta-clamp/clamp loader binding surface; other site 395095000014 beta-clamp/translesion DNA polymerase binding surface; other site 395095000015 recF protein; Region: recf; TIGR00611 395095000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 395095000017 Walker A/P-loop; other site 395095000018 ATP binding site [chemical binding]; other site 395095000019 Q-loop/lid; other site 395095000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 395095000021 ABC transporter signature motif; other site 395095000022 Walker B; other site 395095000023 D-loop; other site 395095000024 H-loop/switch region; other site 395095000025 hypothetical protein; Provisional; Region: PRK03195 395095000026 DNA gyrase subunit A; Validated; Region: PRK05560 395095000027 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 395095000028 CAP-like domain; other site 395095000029 active site 395095000030 primary dimer interface [polypeptide binding]; other site 395095000031 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 395095000032 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 395095000033 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 395095000034 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 395095000035 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 395095000036 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 395095000037 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 395095000038 Protein of unknown function (DUF2562); Region: DUF2562; pfam10814 395095000039 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 395095000040 active site 395095000041 putative septation inhibitor protein; Reviewed; Region: PRK00159 395095000042 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 395095000043 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 395095000044 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 395095000045 Glutamine amidotransferase class-I; Region: GATase; pfam00117 395095000046 glutamine binding [chemical binding]; other site 395095000047 catalytic triad [active] 395095000048 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 395095000049 Catalytic domain of Protein Kinases; Region: PKc; cd00180 395095000050 active site 395095000051 ATP binding site [chemical binding]; other site 395095000052 substrate binding site [chemical binding]; other site 395095000053 activation loop (A-loop); other site 395095000054 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 395095000055 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 395095000056 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 395095000057 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 395095000058 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 395095000059 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 395095000060 Catalytic domain of Protein Kinases; Region: PKc; cd00180 395095000061 active site 395095000062 ATP binding site [chemical binding]; other site 395095000063 substrate binding site [chemical binding]; other site 395095000064 activation loop (A-loop); other site 395095000065 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 395095000066 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 395095000067 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 395095000068 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 395095000069 active site 395095000070 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 395095000071 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 395095000072 phosphopeptide binding site; other site 395095000073 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 395095000074 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 395095000075 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 395095000076 phosphopeptide binding site; other site 395095000077 Transcription factor WhiB; Region: Whib; pfam02467 395095000078 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 395095000079 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 395095000080 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 395095000081 Protein of unknown function (DUF2694); Region: DUF2694; pfam10904 395095000082 Protein of unknown function (DUF2710); Region: DUF2710; pfam10921 395095000083 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 395095000084 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 395095000085 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 395095000086 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 395095000087 acyl-activating enzyme (AAE) consensus motif; other site 395095000088 active site 395095000089 TIGR03084 family protein; Region: TIGR03084 395095000090 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 395095000091 Wyosine base formation; Region: Wyosine_form; pfam08608 395095000092 H+ Antiporter protein; Region: 2A0121; TIGR00900 395095000093 hypothetical protein; Validated; Region: PRK00228 395095000094 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 395095000095 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 395095000096 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 395095000097 active site 395095000098 HIGH motif; other site 395095000099 nucleotide binding site [chemical binding]; other site 395095000100 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 395095000101 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 395095000102 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 395095000103 active site 395095000104 KMSKS motif; other site 395095000105 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 395095000106 tRNA binding surface [nucleotide binding]; other site 395095000107 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 395095000108 MarR family; Region: MarR; pfam01047 395095000109 Transcriptional regulators [Transcription]; Region: FadR; COG2186 395095000110 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 395095000111 DNA-binding site [nucleotide binding]; DNA binding site 395095000112 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 395095000113 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 395095000114 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 395095000115 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 395095000116 inositol 1-phosphate synthase, Actinobacterial type; Region: mycothiol_INO1; TIGR03450 395095000117 Predicted transcriptional regulators [Transcription]; Region: COG1695 395095000118 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 395095000119 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 395095000120 Predicted integral membrane protein [Function unknown]; Region: COG5650 395095000121 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 395095000122 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 395095000123 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 395095000124 dimer interface [polypeptide binding]; other site 395095000125 ssDNA binding site [nucleotide binding]; other site 395095000126 tetramer (dimer of dimers) interface [polypeptide binding]; other site 395095000127 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 395095000128 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 395095000129 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 395095000130 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 395095000131 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 395095000132 ADP-ribose binding site [chemical binding]; other site 395095000133 Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1 [General function prediction only]; Region: COG2110 395095000134 Cellobiohydrolase A (1,4-beta-cellobiosidase A) [Carbohydrate transport and metabolism]; Region: CelA; COG5297 395095000135 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 395095000136 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 395095000137 homotetrameric interface [polypeptide binding]; other site 395095000138 putative active site [active] 395095000139 metal binding site [ion binding]; metal-binding site 395095000140 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 395095000141 Monomeric isocitrate dehydrogenase; Region: IDH; pfam03971 395095000142 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 395095000143 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 395095000144 short chain dehydrogenase; Provisional; Region: PRK06197 395095000145 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 395095000146 putative NAD(P) binding site [chemical binding]; other site 395095000147 active site 395095000148 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 395095000149 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 395095000150 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 395095000151 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 395095000152 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 395095000153 dimer interface [polypeptide binding]; other site 395095000154 active site 395095000155 glycine-pyridoxal phosphate binding site [chemical binding]; other site 395095000156 folate binding site [chemical binding]; other site 395095000157 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 395095000158 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 395095000159 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 395095000160 Walker A/P-loop; other site 395095000161 ATP binding site [chemical binding]; other site 395095000162 Q-loop/lid; other site 395095000163 ABC transporter signature motif; other site 395095000164 Walker B; other site 395095000165 D-loop; other site 395095000166 H-loop/switch region; other site 395095000167 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 395095000168 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 395095000169 ligand binding site [chemical binding]; other site 395095000170 flexible hinge region; other site 395095000171 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 395095000172 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 395095000173 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 395095000174 active site 395095000175 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 395095000176 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 395095000177 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395095000178 homodimer interface [polypeptide binding]; other site 395095000179 catalytic residue [active] 395095000180 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 395095000181 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 395095000182 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 395095000183 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 395095000184 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 395095000185 dimerization interface [polypeptide binding]; other site 395095000186 putative DNA binding site [nucleotide binding]; other site 395095000187 putative Zn2+ binding site [ion binding]; other site 395095000188 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 395095000189 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 395095000190 NADH dehydrogenase; Region: NADHdh; cl00469 395095000191 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 395095000192 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 395095000193 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 395095000194 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 395095000195 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 395095000196 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 395095000197 putative hydrophobic ligand binding site [chemical binding]; other site 395095000198 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395095000199 S-adenosylmethionine binding site [chemical binding]; other site 395095000200 Predicted membrane protein [Function unknown]; Region: COG3305 395095000201 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 395095000202 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 395095000203 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 395095000204 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 395095000205 metal-binding site [ion binding] 395095000206 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 395095000207 Soluble P-type ATPase [General function prediction only]; Region: COG4087 395095000208 Predicted integral membrane protein [Function unknown]; Region: COG5660 395095000209 Putative zinc-finger; Region: zf-HC2; pfam13490 395095000210 Domain of unknown function (DUF222); Region: DUF222; pfam02720 395095000211 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 395095000212 PPE family; Region: PPE; pfam00823 395095000213 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 395095000214 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 395095000215 FcoT-like thioesterase domain; Region: FcoT; pfam10862 395095000216 acyl-CoA synthetase; Validated; Region: PRK05857 395095000217 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 395095000218 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 395095000219 acyl-activating enzyme (AAE) consensus motif; other site 395095000220 acyl-activating enzyme (AAE) consensus motif; other site 395095000221 AMP binding site [chemical binding]; other site 395095000222 active site 395095000223 CoA binding site [chemical binding]; other site 395095000224 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 395095000225 AMP-binding enzyme; Region: AMP-binding; pfam00501 395095000226 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 395095000227 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 395095000228 acyl-activating enzyme (AAE) consensus motif; other site 395095000229 acyl-activating enzyme (AAE) consensus motif; other site 395095000230 active site 395095000231 AMP binding site [chemical binding]; other site 395095000232 CoA binding site [chemical binding]; other site 395095000233 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 395095000234 Condensation domain; Region: Condensation; pfam00668 395095000235 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 395095000236 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 395095000237 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 395095000238 acyl-activating enzyme (AAE) consensus motif; other site 395095000239 AMP binding site [chemical binding]; other site 395095000240 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 395095000241 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 395095000242 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 395095000243 putative NAD(P) binding site [chemical binding]; other site 395095000244 active site 395095000245 putative substrate binding site [chemical binding]; other site 395095000246 Predicted membrane protein [Function unknown]; Region: COG3336 395095000247 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 395095000248 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 395095000249 ligand binding site [chemical binding]; other site 395095000250 flexible hinge region; other site 395095000251 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 395095000252 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 395095000253 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 395095000254 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 395095000255 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 395095000256 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 395095000257 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 395095000258 motif II; other site 395095000259 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 395095000260 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 395095000261 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 395095000262 active site 395095000263 catalytic triad [active] 395095000264 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 395095000265 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 395095000266 NADP-binding site; other site 395095000267 homotetramer interface [polypeptide binding]; other site 395095000268 substrate binding site [chemical binding]; other site 395095000269 homodimer interface [polypeptide binding]; other site 395095000270 active site 395095000271 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 395095000272 dimer interface [polypeptide binding]; other site 395095000273 active site 395095000274 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 395095000275 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 395095000276 active site 395095000277 motif I; other site 395095000278 motif II; other site 395095000279 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 395095000280 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 395095000281 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 395095000282 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 395095000283 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 395095000284 PYR/PP interface [polypeptide binding]; other site 395095000285 dimer interface [polypeptide binding]; other site 395095000286 TPP binding site [chemical binding]; other site 395095000287 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 395095000288 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 395095000289 TPP-binding site; other site 395095000290 dimer interface [polypeptide binding]; other site 395095000291 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 395095000292 elongation factor G; Reviewed; Region: PRK12740 395095000293 G1 box; other site 395095000294 putative GEF interaction site [polypeptide binding]; other site 395095000295 GTP/Mg2+ binding site [chemical binding]; other site 395095000296 Switch I region; other site 395095000297 G2 box; other site 395095000298 G3 box; other site 395095000299 Switch II region; other site 395095000300 G4 box; other site 395095000301 G5 box; other site 395095000302 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 395095000303 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 395095000304 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 395095000305 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 395095000306 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 395095000307 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 395095000308 trehalose synthase; Region: treS_nterm; TIGR02456 395095000309 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 395095000310 active site 395095000311 catalytic site [active] 395095000312 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 395095000313 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 395095000314 Predicted membrane protein [Function unknown]; Region: COG3619 395095000315 Predicted esterase [General function prediction only]; Region: COG0627 395095000316 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 395095000317 putative active site [active] 395095000318 putative catalytic site [active] 395095000319 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 395095000320 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 395095000321 active site 395095000322 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 395095000323 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 395095000324 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 395095000325 Coenzyme A binding pocket [chemical binding]; other site 395095000326 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 395095000327 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 395095000328 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 395095000329 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 395095000330 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 395095000331 Cytochrome P450; Region: p450; cl12078 395095000332 methionine sulfoxide reductase A; Provisional; Region: PRK14054 395095000333 SnoaL-like domain; Region: SnoaL_2; pfam12680 395095000334 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 395095000335 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395095000336 NAD(P) binding site [chemical binding]; other site 395095000337 active site 395095000338 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 395095000339 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 395095000340 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 395095000341 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 395095000342 minor groove reading motif; other site 395095000343 helix-hairpin-helix signature motif; other site 395095000344 active site 395095000345 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 395095000346 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 395095000347 Cl- selectivity filter; other site 395095000348 Cl- binding residues [ion binding]; other site 395095000349 pore gating glutamate residue; other site 395095000350 dimer interface [polypeptide binding]; other site 395095000351 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 395095000352 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 395095000353 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 395095000354 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 395095000355 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 395095000356 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 395095000357 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 395095000358 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 395095000359 NAD(P) binding site [chemical binding]; other site 395095000360 catalytic residues [active] 395095000361 short chain dehydrogenase; Provisional; Region: PRK07791 395095000362 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 395095000363 NAD binding site [chemical binding]; other site 395095000364 homodimer interface [polypeptide binding]; other site 395095000365 active site 395095000366 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 395095000367 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 395095000368 NAD(P) binding site [chemical binding]; other site 395095000369 PE family; Region: PE; pfam00934 395095000370 PE-PPE domain; Region: PE-PPE; pfam08237 395095000371 PE-PPE domain; Region: PE-PPE; pfam08237 395095000372 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 395095000373 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 395095000374 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 395095000375 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 395095000376 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 395095000377 ligand binding site [chemical binding]; other site 395095000378 homodimer interface [polypeptide binding]; other site 395095000379 NAD(P) binding site [chemical binding]; other site 395095000380 trimer interface B [polypeptide binding]; other site 395095000381 trimer interface A [polypeptide binding]; other site 395095000382 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 395095000383 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 395095000384 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 395095000385 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 395095000386 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 395095000387 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 395095000388 PE family; Region: PE; pfam00934 395095000389 PE-PPE domain; Region: PE-PPE; pfam08237 395095000390 PE family; Region: PE; pfam00934 395095000391 PE-PPE domain; Region: PE-PPE; pfam08237 395095000392 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 395095000393 FAD binding domain; Region: FAD_binding_4; pfam01565 395095000394 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 395095000395 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 395095000396 NAD(P) binding site [chemical binding]; other site 395095000397 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 395095000398 active site 395095000399 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 395095000400 putative hydrophobic ligand binding site [chemical binding]; other site 395095000401 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786 395095000402 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 395095000403 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 395095000404 acyl-activating enzyme (AAE) consensus motif; other site 395095000405 acyl-activating enzyme (AAE) consensus motif; other site 395095000406 putative AMP binding site [chemical binding]; other site 395095000407 putative active site [active] 395095000408 putative CoA binding site [chemical binding]; other site 395095000409 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 395095000410 Permease; Region: Permease; pfam02405 395095000411 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 395095000412 Permease; Region: Permease; pfam02405 395095000413 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 395095000414 mce related protein; Region: MCE; pfam02470 395095000415 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 395095000416 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 395095000417 mce related protein; Region: MCE; pfam02470 395095000418 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 395095000419 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 395095000420 mce related protein; Region: MCE; pfam02470 395095000421 RDD family; Region: RDD; pfam06271 395095000422 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 395095000423 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 395095000424 Predicted membrane protein [Function unknown]; Region: COG1511 395095000425 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 395095000426 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 395095000427 Pirin-related protein [General function prediction only]; Region: COG1741 395095000428 Pirin; Region: Pirin; pfam02678 395095000429 RNA polymerase factor sigma-70; Validated; Region: PRK08241 395095000430 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 395095000431 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 395095000432 DNA binding residues [nucleotide binding] 395095000433 SnoaL-like domain; Region: SnoaL_2; pfam12680 395095000434 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 395095000435 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 395095000436 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 395095000437 putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185 395095000438 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 395095000439 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 395095000440 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 395095000441 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 395095000442 SPW repeat; Region: SPW; pfam03779 395095000443 SPW repeat; Region: SPW; pfam03779 395095000444 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 395095000445 6-phosphogluconate dehydratase; Region: edd; TIGR01196 395095000446 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 395095000447 putative homodimer interface [polypeptide binding]; other site 395095000448 putative homotetramer interface [polypeptide binding]; other site 395095000449 putative allosteric switch controlling residues; other site 395095000450 putative metal binding site [ion binding]; other site 395095000451 putative homodimer-homodimer interface [polypeptide binding]; other site 395095000452 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 395095000453 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 395095000454 putative substrate translocation pore; other site 395095000455 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 395095000456 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 395095000457 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 395095000458 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 395095000459 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 395095000460 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 395095000461 Walker A/P-loop; other site 395095000462 ATP binding site [chemical binding]; other site 395095000463 Q-loop/lid; other site 395095000464 ABC transporter signature motif; other site 395095000465 Walker B; other site 395095000466 D-loop; other site 395095000467 H-loop/switch region; other site 395095000468 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 395095000469 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 395095000470 Walker A/P-loop; other site 395095000471 ATP binding site [chemical binding]; other site 395095000472 Q-loop/lid; other site 395095000473 ABC transporter signature motif; other site 395095000474 Walker B; other site 395095000475 D-loop; other site 395095000476 H-loop/switch region; other site 395095000477 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 395095000478 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 395095000479 dimerization interface [polypeptide binding]; other site 395095000480 DNA binding residues [nucleotide binding] 395095000481 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 395095000482 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 395095000483 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 395095000484 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 395095000485 putative [Fe4-S4] binding site [ion binding]; other site 395095000486 putative molybdopterin cofactor binding site [chemical binding]; other site 395095000487 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 395095000488 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 395095000489 putative molybdopterin cofactor binding site; other site 395095000490 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 395095000491 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 395095000492 Predicted integral membrane protein [Function unknown]; Region: COG0392 395095000493 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 395095000494 Domain of unknown function DUF20; Region: UPF0118; pfam01594 395095000495 Putative methyltransferase; Region: Methyltransf_4; pfam02390 395095000496 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 395095000497 active site 395095000498 substrate-binding site [chemical binding]; other site 395095000499 metal-binding site [ion binding] 395095000500 GTP binding site [chemical binding]; other site 395095000501 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 395095000502 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 395095000503 active site 395095000504 (T/H)XGH motif; other site 395095000505 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 395095000506 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 395095000507 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 395095000508 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 395095000509 acyl-activating enzyme (AAE) consensus motif; other site 395095000510 acyl-activating enzyme (AAE) consensus motif; other site 395095000511 putative AMP binding site [chemical binding]; other site 395095000512 putative active site [active] 395095000513 putative CoA binding site [chemical binding]; other site 395095000514 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 395095000515 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 395095000516 active site 395095000517 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 395095000518 putative active site [active] 395095000519 putative catalytic site [active] 395095000520 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 395095000521 active site 2 [active] 395095000522 active site 1 [active] 395095000523 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 395095000524 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 395095000525 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 395095000526 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 395095000527 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 395095000528 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 395095000529 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 395095000530 enoyl-CoA hydratase; Provisional; Region: PRK08252 395095000531 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 395095000532 substrate binding site [chemical binding]; other site 395095000533 oxyanion hole (OAH) forming residues; other site 395095000534 trimer interface [polypeptide binding]; other site 395095000535 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 395095000536 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 395095000537 NAD binding site [chemical binding]; other site 395095000538 catalytic residues [active] 395095000539 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395095000540 S-adenosylmethionine binding site [chemical binding]; other site 395095000541 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 395095000542 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 395095000543 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 395095000544 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 395095000545 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 395095000546 active site 395095000547 substrate binding pocket [chemical binding]; other site 395095000548 homodimer interaction site [polypeptide binding]; other site 395095000549 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 395095000550 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 395095000551 active site 395095000552 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 395095000553 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 395095000554 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 395095000555 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 395095000556 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 395095000557 NAD(P) binding site [chemical binding]; other site 395095000558 catalytic residues [active] 395095000559 Lipase maturation factor; Region: LMF1; pfam06762 395095000560 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 395095000561 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 395095000562 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 395095000563 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 395095000564 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 395095000565 MaoC like domain; Region: MaoC_dehydratas; pfam01575 395095000566 active site 2 [active] 395095000567 active site 1 [active] 395095000568 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 395095000569 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395095000570 NAD(P) binding site [chemical binding]; other site 395095000571 active site 395095000572 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 395095000573 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 395095000574 dimer interface [polypeptide binding]; other site 395095000575 active site 395095000576 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 395095000577 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 395095000578 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 395095000579 FAD binding site [chemical binding]; other site 395095000580 substrate binding site [chemical binding]; other site 395095000581 catalytic residues [active] 395095000582 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 395095000583 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 395095000584 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 395095000585 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 395095000586 catalytic loop [active] 395095000587 iron binding site [ion binding]; other site 395095000588 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 395095000589 L-aspartate oxidase; Provisional; Region: PRK06175 395095000590 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 395095000591 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 395095000592 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 395095000593 putative dimer interface [polypeptide binding]; other site 395095000594 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 395095000595 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 395095000596 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 395095000597 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 395095000598 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 395095000599 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 395095000600 homotrimer interface [polypeptide binding]; other site 395095000601 Walker A motif; other site 395095000602 GTP binding site [chemical binding]; other site 395095000603 Walker B motif; other site 395095000604 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 395095000605 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 395095000606 putative active site [active] 395095000607 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 395095000608 putative active site [active] 395095000609 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 395095000610 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 395095000611 active site 395095000612 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 395095000613 DNA binding site [nucleotide binding] 395095000614 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 395095000615 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 395095000616 Coenzyme A binding pocket [chemical binding]; other site 395095000617 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 395095000618 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 395095000619 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 395095000620 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 395095000621 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 395095000622 intersubunit interface [polypeptide binding]; other site 395095000623 5-oxoprolinase; Region: PLN02666 395095000624 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 395095000625 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 395095000626 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 395095000627 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 395095000628 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 395095000629 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 395095000630 nucleotide binding site [chemical binding]; other site 395095000631 acyl-CoA synthetase; Validated; Region: PRK07788 395095000632 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 395095000633 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 395095000634 active site 395095000635 CoA binding site [chemical binding]; other site 395095000636 AMP binding site [chemical binding]; other site 395095000637 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 395095000638 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 395095000639 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 395095000640 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 395095000641 FAD binding site [chemical binding]; other site 395095000642 substrate binding site [chemical binding]; other site 395095000643 catalytic base [active] 395095000644 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 395095000645 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 395095000646 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 395095000647 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 395095000648 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 395095000649 putative active site [active] 395095000650 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 395095000651 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 395095000652 Protein of unknown function (DUF690); Region: DUF690; pfam05108 395095000653 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 395095000654 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 395095000655 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 395095000656 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 395095000657 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 395095000658 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 395095000659 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 395095000660 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 395095000661 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 395095000662 active site 395095000663 catalytic residues [active] 395095000664 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 395095000665 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 395095000666 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 395095000667 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 395095000668 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395095000669 S-adenosylmethionine binding site [chemical binding]; other site 395095000670 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4424 395095000671 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 395095000672 putative active site [active] 395095000673 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 395095000674 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 395095000675 light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs; Region: LPOR_like_SDR_c_like; cd09810 395095000676 protochlorophyllide reductase; Region: PLN00015 395095000677 putative NAD(P) binding site [chemical binding]; other site 395095000678 active site 395095000679 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 395095000680 PPE family; Region: PPE; pfam00823 395095000681 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 395095000682 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 395095000683 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 395095000684 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 395095000685 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 395095000686 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 395095000687 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 395095000688 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 395095000689 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 395095000690 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 395095000691 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 395095000692 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 395095000693 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 395095000694 putative FMN binding site [chemical binding]; other site 395095000695 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 395095000696 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 395095000697 active site 395095000698 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 395095000699 SnoaL-like domain; Region: SnoaL_4; pfam13577 395095000700 SnoaL-like domain; Region: SnoaL_3; pfam13474 395095000701 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 395095000702 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 395095000703 nucleotide binding site [chemical binding]; other site 395095000704 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]; Region: HtpG; COG0326 395095000705 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 395095000706 Muconolactone delta-isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CatC1; COG4829 395095000707 Muconolactone delta-isomerase; Region: MIase; cl01992 395095000708 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 395095000709 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 395095000710 putative active site [active] 395095000711 catalytic site [active] 395095000712 putative metal binding site [ion binding]; other site 395095000713 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 395095000714 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 395095000715 putative substrate binding pocket [chemical binding]; other site 395095000716 AC domain interface; other site 395095000717 catalytic triad [active] 395095000718 AB domain interface; other site 395095000719 interchain disulfide; other site 395095000720 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 395095000721 trimer interface [polypeptide binding]; other site 395095000722 active site 395095000723 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 395095000724 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 395095000725 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 395095000726 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 395095000727 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 395095000728 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 395095000729 dimerization interface [polypeptide binding]; other site 395095000730 putative DNA binding site [nucleotide binding]; other site 395095000731 putative Zn2+ binding site [ion binding]; other site 395095000732 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 395095000733 active site residue [active] 395095000734 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395095000735 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 395095000736 Cytochrome P450; Region: p450; cl12078 395095000737 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 395095000738 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 395095000739 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 395095000740 Methyltransferase domain; Region: Methyltransf_23; pfam13489 395095000741 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395095000742 S-adenosylmethionine binding site [chemical binding]; other site 395095000743 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 395095000744 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 395095000745 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 395095000746 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 395095000747 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 395095000748 SnoaL-like domain; Region: SnoaL_2; pfam12680 395095000749 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 395095000750 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 395095000751 substrate binding site; other site 395095000752 tetramer interface; other site 395095000753 PE family; Region: PE; pfam00934 395095000754 Domain of unknown function (DUF222); Region: DUF222; pfam02720 395095000755 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 395095000756 active site 395095000757 aminotransferase AlaT; Validated; Region: PRK09265 395095000758 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 395095000759 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395095000760 homodimer interface [polypeptide binding]; other site 395095000761 catalytic residue [active] 395095000762 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 395095000763 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 395095000764 DNA binding residues [nucleotide binding] 395095000765 dimerization interface [polypeptide binding]; other site 395095000766 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 395095000767 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 395095000768 G1 box; other site 395095000769 GTP/Mg2+ binding site [chemical binding]; other site 395095000770 G2 box; other site 395095000771 Switch I region; other site 395095000772 G3 box; other site 395095000773 Switch II region; other site 395095000774 G4 box; other site 395095000775 G5 box; other site 395095000776 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 395095000777 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 395095000778 G1 box; other site 395095000779 GTP/Mg2+ binding site [chemical binding]; other site 395095000780 G2 box; other site 395095000781 Switch I region; other site 395095000782 G3 box; other site 395095000783 Switch II region; other site 395095000784 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 395095000785 TIGR04255 family protein; Region: sporadTIGR04255 395095000786 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 395095000787 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 395095000788 nucleotide binding site [chemical binding]; other site 395095000789 NEF interaction site [polypeptide binding]; other site 395095000790 SBD interface [polypeptide binding]; other site 395095000791 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 395095000792 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 395095000793 dimer interface [polypeptide binding]; other site 395095000794 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 395095000795 Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279 395095000796 DNA binding residues [nucleotide binding] 395095000797 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 395095000798 putative dimer interface [polypeptide binding]; other site 395095000799 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 395095000800 PPE family; Region: PPE; pfam00823 395095000801 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 395095000802 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 395095000803 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 395095000804 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 395095000805 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 395095000806 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 395095000807 GDP-binding site [chemical binding]; other site 395095000808 ACT binding site; other site 395095000809 IMP binding site; other site 395095000810 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 395095000811 Peptidase family M50; Region: Peptidase_M50; pfam02163 395095000812 active site 395095000813 putative substrate binding region [chemical binding]; other site 395095000814 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 395095000815 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 395095000816 MgtE intracellular N domain; Region: MgtE_N; pfam03448 395095000817 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 395095000818 Divalent cation transporter; Region: MgtE; pfam01769 395095000819 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 395095000820 fructose-bisphosphate aldolase, class II, yeast/E. coli subtype; Region: FruBisAldo_II_A; TIGR01520 395095000821 active site 395095000822 intersubunit interface [polypeptide binding]; other site 395095000823 zinc binding site [ion binding]; other site 395095000824 Na+ binding site [ion binding]; other site 395095000825 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 395095000826 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 395095000827 Predicted glycosyl hydrolase [Carbohydrate transport and metabolism]; Region: COG4833 395095000828 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 395095000829 AAA domain; Region: AAA_33; pfam13671 395095000830 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 395095000831 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 395095000832 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 395095000833 putative hydrophobic ligand binding site [chemical binding]; other site 395095000834 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 395095000835 Ligand binding site; other site 395095000836 metal-binding site 395095000837 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 395095000838 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 395095000839 XdhC Rossmann domain; Region: XdhC_C; pfam13478 395095000840 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 395095000841 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 395095000842 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 395095000843 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 395095000844 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 395095000845 catalytic loop [active] 395095000846 iron binding site [ion binding]; other site 395095000847 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 395095000848 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 395095000849 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 395095000850 Transcriptional regulator [Transcription]; Region: LysR; COG0583 395095000851 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 395095000852 LysR substrate binding domain; Region: LysR_substrate; pfam03466 395095000853 dimerization interface [polypeptide binding]; other site 395095000854 Uncharacterized conserved protein [Function unknown]; Region: COG3360 395095000855 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 395095000856 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 395095000857 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 395095000858 active site 395095000859 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 395095000860 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 395095000861 heme-binding site [chemical binding]; other site 395095000862 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 395095000863 FAD binding pocket [chemical binding]; other site 395095000864 FAD binding motif [chemical binding]; other site 395095000865 phosphate binding motif [ion binding]; other site 395095000866 beta-alpha-beta structure motif; other site 395095000867 NAD binding pocket [chemical binding]; other site 395095000868 Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase) [Nucleotide transport and metabolism]; Region: PurT; COG0027 395095000869 ATP-grasp domain; Region: ATP-grasp_4; cl17255 395095000870 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 395095000871 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 395095000872 homodimer interface [polypeptide binding]; other site 395095000873 substrate-cofactor binding pocket; other site 395095000874 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395095000875 catalytic residue [active] 395095000876 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 395095000877 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 395095000878 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 395095000879 Domain of unknown function (DUF222); Region: DUF222; pfam02720 395095000880 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 395095000881 active site 395095000882 PLD-like domain; Region: PLDc_2; pfam13091 395095000883 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 395095000884 Beta-lactamase; Region: Beta-lactamase; pfam00144 395095000885 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 395095000886 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 395095000887 FAD binding site [chemical binding]; other site 395095000888 substrate binding pocket [chemical binding]; other site 395095000889 catalytic base [active] 395095000890 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 395095000891 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 395095000892 putative transposase OrfB; Reviewed; Region: PHA02517 395095000893 HTH-like domain; Region: HTH_21; pfam13276 395095000894 Integrase core domain; Region: rve; pfam00665 395095000895 Integrase core domain; Region: rve_3; pfam13683 395095000896 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 395095000897 acyl-CoA synthetase; Validated; Region: PRK05850 395095000898 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 395095000899 acyl-activating enzyme (AAE) consensus motif; other site 395095000900 active site 395095000901 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 395095000902 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 395095000903 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 395095000904 active site 395095000905 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 395095000906 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 395095000907 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 395095000908 Thioesterase; Region: PKS_TE; smart00824 395095000909 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 395095000910 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 395095000911 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 395095000912 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 395095000913 phosphate acetyltransferase; Reviewed; Region: PRK05632 395095000914 DRTGG domain; Region: DRTGG; pfam07085 395095000915 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 395095000916 propionate/acetate kinase; Provisional; Region: PRK12379 395095000917 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 395095000918 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 395095000919 Catalytic domain of Protein Kinases; Region: PKc; cd00180 395095000920 active site 395095000921 ATP binding site [chemical binding]; other site 395095000922 substrate binding site [chemical binding]; other site 395095000923 activation loop (A-loop); other site 395095000924 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 395095000925 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 395095000926 substrate binding pocket [chemical binding]; other site 395095000927 membrane-bound complex binding site; other site 395095000928 hinge residues; other site 395095000929 NUDIX domain; Region: NUDIX; pfam00293 395095000930 nudix motif; other site 395095000931 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 395095000932 thiamine phosphate binding site [chemical binding]; other site 395095000933 active site 395095000934 pyrophosphate binding site [ion binding]; other site 395095000935 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 395095000936 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 395095000937 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 395095000938 thiS-thiF/thiG interaction site; other site 395095000939 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 395095000940 ThiS interaction site; other site 395095000941 putative active site [active] 395095000942 tetramer interface [polypeptide binding]; other site 395095000943 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 395095000944 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 395095000945 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 395095000946 PA/protease or protease-like domain interface [polypeptide binding]; other site 395095000947 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 395095000948 active site 395095000949 metal binding site [ion binding]; metal-binding site 395095000950 Predicted metalloprotease [General function prediction only]; Region: COG2321 395095000951 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 395095000952 Zn binding site [ion binding]; other site 395095000953 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 395095000954 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 395095000955 ThiC-associated domain; Region: ThiC-associated; pfam13667 395095000956 ThiC family; Region: ThiC; pfam01964 395095000957 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 395095000958 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 395095000959 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 395095000960 motif II; other site 395095000961 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 395095000962 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 395095000963 putative catalytic site [active] 395095000964 putative phosphate binding site [ion binding]; other site 395095000965 active site 395095000966 metal binding site A [ion binding]; metal-binding site 395095000967 DNA binding site [nucleotide binding] 395095000968 putative AP binding site [nucleotide binding]; other site 395095000969 putative metal binding site B [ion binding]; other site 395095000970 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 395095000971 active site 395095000972 catalytic residues [active] 395095000973 metal binding site [ion binding]; metal-binding site 395095000974 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 395095000975 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 395095000976 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 395095000977 E-class dimer interface [polypeptide binding]; other site 395095000978 P-class dimer interface [polypeptide binding]; other site 395095000979 active site 395095000980 Cu2+ binding site [ion binding]; other site 395095000981 Zn2+ binding site [ion binding]; other site 395095000982 carboxylate-amine ligase; Provisional; Region: PRK13517 395095000983 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 395095000984 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 395095000985 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 395095000986 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 395095000987 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 395095000988 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 395095000989 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 395095000990 dimer interface [polypeptide binding]; other site 395095000991 putative functional site; other site 395095000992 putative MPT binding site; other site 395095000993 short chain dehydrogenase; Provisional; Region: PRK06197 395095000994 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 395095000995 putative NAD(P) binding site [chemical binding]; other site 395095000996 active site 395095000997 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 395095000998 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 395095000999 ring oligomerisation interface [polypeptide binding]; other site 395095001000 ATP/Mg binding site [chemical binding]; other site 395095001001 stacking interactions; other site 395095001002 hinge regions; other site 395095001003 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 395095001004 PPE family; Region: PPE; pfam00823 395095001005 Protein of unknown function (DUF664); Region: DUF664; pfam04978 395095001006 DinB superfamily; Region: DinB_2; pfam12867 395095001007 putative anti-sigmaE protein; Provisional; Region: PRK13920 395095001008 Anti-sigma-K factor rskA; Region: RskA; pfam10099 395095001009 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 395095001010 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 395095001011 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 395095001012 DNA binding residues [nucleotide binding] 395095001013 Steroid 5-alpha reductase family enzyme [General function prediction only]; Region: COG3752 395095001014 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 395095001015 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395095001016 S-adenosylmethionine binding site [chemical binding]; other site 395095001017 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 395095001018 Subunit A of Class III extradiol dioxygenases; Region: Extradiol_Dioxygenase_3A_like; cl06673 395095001019 dimer interface [polypeptide binding]; other site 395095001020 Transport protein; Region: actII; TIGR00833 395095001021 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 395095001022 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 395095001023 PPE family; Region: PPE; pfam00823 395095001024 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 395095001025 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 395095001026 enoyl-CoA hydratase; Provisional; Region: PRK12478 395095001027 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 395095001028 substrate binding site [chemical binding]; other site 395095001029 oxyanion hole (OAH) forming residues; other site 395095001030 trimer interface [polypeptide binding]; other site 395095001031 PemK-like protein; Region: PemK; pfam02452 395095001032 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 395095001033 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 395095001034 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 395095001035 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 395095001036 Uncharacterized conserved protein [Function unknown]; Region: COG2128 395095001037 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 395095001038 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 395095001039 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 395095001040 non-specific DNA binding site [nucleotide binding]; other site 395095001041 salt bridge; other site 395095001042 sequence-specific DNA binding site [nucleotide binding]; other site 395095001043 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 395095001044 Domain of unknown function (DUF955); Region: DUF955; pfam06114 395095001045 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 395095001046 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 395095001047 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 395095001048 active site 395095001049 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 395095001050 active site 2 [active] 395095001051 isocitrate lyase; Provisional; Region: PRK15063 395095001052 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cd06556 395095001053 oligomerization interface [polypeptide binding]; other site 395095001054 active site 395095001055 metal binding site [ion binding]; metal-binding site 395095001056 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 395095001057 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 395095001058 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 395095001059 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 395095001060 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395095001061 S-adenosylmethionine binding site [chemical binding]; other site 395095001062 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 395095001063 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 395095001064 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395095001065 S-adenosylmethionine binding site [chemical binding]; other site 395095001066 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 395095001067 UbiA prenyltransferase family; Region: UbiA; pfam01040 395095001068 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 395095001069 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 395095001070 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 395095001071 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 395095001072 non-specific DNA binding site [nucleotide binding]; other site 395095001073 salt bridge; other site 395095001074 sequence-specific DNA binding site [nucleotide binding]; other site 395095001075 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 395095001076 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 395095001077 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 395095001078 intersubunit interface [polypeptide binding]; other site 395095001079 active site 395095001080 catalytic residue [active] 395095001081 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 395095001082 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 395095001083 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 395095001084 FAD binding domain; Region: FAD_binding_4; pfam01565 395095001085 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 395095001086 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 395095001087 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 395095001088 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 395095001089 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 395095001090 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 395095001091 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395095001092 NAD(P) binding site [chemical binding]; other site 395095001093 active site 395095001094 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 395095001095 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 395095001096 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 395095001097 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 395095001098 putative ADP-binding pocket [chemical binding]; other site 395095001099 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 395095001100 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395095001101 dimer interface [polypeptide binding]; other site 395095001102 phosphorylation site [posttranslational modification] 395095001103 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395095001104 ATP binding site [chemical binding]; other site 395095001105 Mg2+ binding site [ion binding]; other site 395095001106 G-X-G motif; other site 395095001107 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 395095001108 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395095001109 active site 395095001110 phosphorylation site [posttranslational modification] 395095001111 intermolecular recognition site; other site 395095001112 dimerization interface [polypeptide binding]; other site 395095001113 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 395095001114 DNA binding site [nucleotide binding] 395095001115 Transcriptional regulators [Transcription]; Region: FadR; COG2186 395095001116 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 395095001117 DNA-binding site [nucleotide binding]; DNA binding site 395095001118 FCD domain; Region: FCD; pfam07729 395095001119 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 395095001120 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 395095001121 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 395095001122 Diacylglycerol kinase catalytic domain (presumed); Region: DAGKc; smart00046 395095001123 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 395095001124 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 395095001125 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 395095001126 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 395095001127 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 395095001128 putative NAD(P) binding site [chemical binding]; other site 395095001129 active site 395095001130 putative substrate binding site [chemical binding]; other site 395095001131 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 395095001132 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 395095001133 putative acyl-acceptor binding pocket; other site 395095001134 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 395095001135 active site 395095001136 catalytic site [active] 395095001137 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 395095001138 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 395095001139 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 395095001140 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 395095001141 glutamyl-tRNA reductase; Region: hemA; TIGR01035 395095001142 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 395095001143 tRNA; other site 395095001144 putative tRNA binding site [nucleotide binding]; other site 395095001145 putative NADP binding site [chemical binding]; other site 395095001146 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 395095001147 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 395095001148 active site 395095001149 homodimer interface [polypeptide binding]; other site 395095001150 SAM binding site [chemical binding]; other site 395095001151 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 395095001152 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 395095001153 active site 395095001154 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 395095001155 dimer interface [polypeptide binding]; other site 395095001156 active site 395095001157 Schiff base residues; other site 395095001158 Domain of unknown function (DUF222); Region: DUF222; pfam02720 395095001159 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 395095001160 active site 395095001161 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 395095001162 anti sigma factor interaction site; other site 395095001163 regulatory phosphorylation site [posttranslational modification]; other site 395095001164 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 395095001165 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 395095001166 active site 395095001167 catalytic triad [active] 395095001168 oxyanion hole [active] 395095001169 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 395095001170 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395095001171 Methyltransferase domain; Region: Methyltransf_31; pfam13847 395095001172 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 395095001173 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 395095001174 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 395095001175 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 395095001176 catalytic residue [active] 395095001177 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 395095001178 catalytic core [active] 395095001179 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 395095001180 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 395095001181 catalytic residues [active] 395095001182 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 395095001183 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 395095001184 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 395095001185 3-oxoacyl-(acyl-carrier-protein) synthase III; Region: fabH; TIGR00747 395095001186 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 395095001187 dimer interface [polypeptide binding]; other site 395095001188 active site 395095001189 CoA binding pocket [chemical binding]; other site 395095001190 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 395095001191 UbiA prenyltransferase family; Region: UbiA; pfam01040 395095001192 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 395095001193 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395095001194 NAD(P) binding site [chemical binding]; other site 395095001195 active site 395095001196 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 395095001197 Ligand binding site; other site 395095001198 Putative Catalytic site; other site 395095001199 DXD motif; other site 395095001200 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3222 395095001201 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 395095001202 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 395095001203 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 395095001204 acyl-activating enzyme (AAE) consensus motif; other site 395095001205 acyl-activating enzyme (AAE) consensus motif; other site 395095001206 AMP binding site [chemical binding]; other site 395095001207 active site 395095001208 CoA binding site [chemical binding]; other site 395095001209 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 395095001210 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 395095001211 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 395095001212 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 395095001213 active site 395095001214 short chain dehydrogenase; Provisional; Region: PRK05866 395095001215 classical (c) SDRs; Region: SDR_c; cd05233 395095001216 NAD(P) binding site [chemical binding]; other site 395095001217 active site 395095001218 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 395095001219 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 395095001220 substrate binding site [chemical binding]; other site 395095001221 oxyanion hole (OAH) forming residues; other site 395095001222 trimer interface [polypeptide binding]; other site 395095001223 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 395095001224 putative active site [active] 395095001225 homotetrameric interface [polypeptide binding]; other site 395095001226 metal binding site [ion binding]; metal-binding site 395095001227 acyl-CoA synthetase; Validated; Region: PRK06188 395095001228 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 395095001229 putative active site [active] 395095001230 putative CoA binding site [chemical binding]; other site 395095001231 putative AMP binding site [chemical binding]; other site 395095001232 O-succinylbenzoate synthase; Provisional; Region: PRK02901 395095001233 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 395095001234 active site 395095001235 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 395095001236 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 395095001237 TAP-like protein; Region: Abhydrolase_4; pfam08386 395095001238 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 395095001239 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 395095001240 dimer interface [polypeptide binding]; other site 395095001241 tetramer interface [polypeptide binding]; other site 395095001242 PYR/PP interface [polypeptide binding]; other site 395095001243 TPP binding site [chemical binding]; other site 395095001244 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 395095001245 TPP-binding site; other site 395095001246 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 395095001247 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 395095001248 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 395095001249 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 395095001250 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395095001251 S-adenosylmethionine binding site [chemical binding]; other site 395095001252 Protein of unknown function (DUF732); Region: DUF732; pfam05305 395095001253 Methyltransferase domain; Region: Methyltransf_23; pfam13489 395095001254 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395095001255 S-adenosylmethionine binding site [chemical binding]; other site 395095001256 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 395095001257 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 395095001258 substrate binding pocket [chemical binding]; other site 395095001259 chain length determination region; other site 395095001260 substrate-Mg2+ binding site; other site 395095001261 catalytic residues [active] 395095001262 aspartate-rich region 1; other site 395095001263 active site lid residues [active] 395095001264 aspartate-rich region 2; other site 395095001265 heat shock protein HtpX; Provisional; Region: PRK03072 395095001266 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 395095001267 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 395095001268 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 395095001269 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 395095001270 O-methyltransferase; Region: Methyltransf_2; pfam00891 395095001271 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 395095001272 Cytochrome P450; Region: p450; cl12078 395095001273 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 395095001274 active site 395095001275 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 395095001276 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 395095001277 nicotinate phosphoribosyltransferase; Provisional; Region: PRK12484 395095001278 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 395095001279 active site 395095001280 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 395095001281 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 395095001282 putative active site [active] 395095001283 putative metal binding site [ion binding]; other site 395095001284 hypothetical protein; Provisional; Region: PRK07588 395095001285 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 395095001286 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451 395095001287 Uncharacterized conserved protein [Function unknown]; Region: COG1656 395095001288 Protein of unknown function DUF82; Region: DUF82; pfam01927 395095001289 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 395095001290 putative active site [active] 395095001291 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 395095001292 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 395095001293 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 395095001294 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 395095001295 Transcriptional regulators [Transcription]; Region: FadR; COG2186 395095001296 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 395095001297 DNA-binding site [nucleotide binding]; DNA binding site 395095001298 FCD domain; Region: FCD; pfam07729 395095001299 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 395095001300 Permease; Region: Permease; pfam02405 395095001301 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 395095001302 Permease; Region: Permease; pfam02405 395095001303 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 395095001304 mce related protein; Region: MCE; pfam02470 395095001305 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 395095001306 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 395095001307 mce related protein; Region: MCE; pfam02470 395095001308 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 395095001309 mce related protein; Region: MCE; pfam02470 395095001310 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 395095001311 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 395095001312 mce related protein; Region: MCE; pfam02470 395095001313 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 395095001314 oligomeric interface; other site 395095001315 putative active site [active] 395095001316 homodimer interface [polypeptide binding]; other site 395095001317 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 395095001318 AAA domain; Region: AAA_14; pfam13173 395095001319 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 395095001320 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395095001321 ATP binding site [chemical binding]; other site 395095001322 Mg2+ binding site [ion binding]; other site 395095001323 G-X-G motif; other site 395095001324 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 395095001325 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395095001326 active site 395095001327 phosphorylation site [posttranslational modification] 395095001328 intermolecular recognition site; other site 395095001329 dimerization interface [polypeptide binding]; other site 395095001330 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 395095001331 DNA binding site [nucleotide binding] 395095001332 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 395095001333 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 395095001334 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 395095001335 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 395095001336 catalytic residues [active] 395095001337 catalytic nucleophile [active] 395095001338 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 395095001339 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 395095001340 Probable transposase; Region: OrfB_IS605; pfam01385 395095001341 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 395095001342 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 395095001343 putative active site [active] 395095001344 SEC-C motif; Region: SEC-C; pfam02810 395095001345 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB-like; cd09875 395095001346 putative active site [active] 395095001347 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 395095001348 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 395095001349 nucleotide binding site/active site [active] 395095001350 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 395095001351 Protein of unknown function (DUF732); Region: DUF732; pfam05305 395095001352 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 395095001353 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 395095001354 putative active site [active] 395095001355 Uncharacterized conserved protein [Function unknown]; Region: COG0398 395095001356 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 395095001357 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 395095001358 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 395095001359 oligomeric interface; other site 395095001360 putative active site [active] 395095001361 homodimer interface [polypeptide binding]; other site 395095001362 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 395095001363 FIST N domain; Region: FIST; pfam08495 395095001364 FIST C domain; Region: FIST_C; pfam10442 395095001365 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 395095001366 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 395095001367 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 395095001368 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 395095001369 substrate binding site [chemical binding]; other site 395095001370 oxyanion hole (OAH) forming residues; other site 395095001371 trimer interface [polypeptide binding]; other site 395095001372 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 395095001373 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 395095001374 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 395095001375 active site 395095001376 catalytic site [active] 395095001377 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 395095001378 active site 395095001379 catalytic site [active] 395095001380 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 395095001381 active site 395095001382 catalytic site [active] 395095001383 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 395095001384 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 395095001385 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 395095001386 putative homodimer interface [polypeptide binding]; other site 395095001387 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 395095001388 heterodimer interface [polypeptide binding]; other site 395095001389 homodimer interface [polypeptide binding]; other site 395095001390 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 395095001391 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 395095001392 23S rRNA interface [nucleotide binding]; other site 395095001393 L7/L12 interface [polypeptide binding]; other site 395095001394 putative thiostrepton binding site; other site 395095001395 L25 interface [polypeptide binding]; other site 395095001396 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 395095001397 mRNA/rRNA interface [nucleotide binding]; other site 395095001398 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 395095001399 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395095001400 S-adenosylmethionine binding site [chemical binding]; other site 395095001401 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 395095001402 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 395095001403 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395095001404 S-adenosylmethionine binding site [chemical binding]; other site 395095001405 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 395095001406 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 395095001407 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395095001408 S-adenosylmethionine binding site [chemical binding]; other site 395095001409 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 395095001410 TAP-like protein; Region: Abhydrolase_4; pfam08386 395095001411 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 395095001412 23S rRNA interface [nucleotide binding]; other site 395095001413 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 395095001414 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 395095001415 core dimer interface [polypeptide binding]; other site 395095001416 peripheral dimer interface [polypeptide binding]; other site 395095001417 L10 interface [polypeptide binding]; other site 395095001418 L11 interface [polypeptide binding]; other site 395095001419 putative EF-Tu interaction site [polypeptide binding]; other site 395095001420 putative EF-G interaction site [polypeptide binding]; other site 395095001421 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 395095001422 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 395095001423 WHG domain; Region: WHG; pfam13305 395095001424 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 395095001425 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 395095001426 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 395095001427 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 395095001428 Walker A/P-loop; other site 395095001429 ATP binding site [chemical binding]; other site 395095001430 Q-loop/lid; other site 395095001431 ABC transporter signature motif; other site 395095001432 Walker B; other site 395095001433 D-loop; other site 395095001434 H-loop/switch region; other site 395095001435 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 395095001436 putative active site [active] 395095001437 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 395095001438 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 395095001439 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG1848 395095001440 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 395095001441 Sulfatase; Region: Sulfatase; pfam00884 395095001442 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 395095001443 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 395095001444 putative active site [active] 395095001445 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 395095001446 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 395095001447 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 395095001448 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 395095001449 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 395095001450 RPB10 interaction site [polypeptide binding]; other site 395095001451 RPB1 interaction site [polypeptide binding]; other site 395095001452 RPB11 interaction site [polypeptide binding]; other site 395095001453 RPB3 interaction site [polypeptide binding]; other site 395095001454 RPB12 interaction site [polypeptide binding]; other site 395095001455 endonuclease IV; Provisional; Region: PRK01060 395095001456 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 395095001457 AP (apurinic/apyrimidinic) site pocket; other site 395095001458 DNA interaction; other site 395095001459 Metal-binding active site; metal-binding site 395095001460 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 395095001461 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 395095001462 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 395095001463 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 395095001464 active site 395095001465 enoyl-CoA hydratase; Provisional; Region: PRK12478 395095001466 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 395095001467 substrate binding site [chemical binding]; other site 395095001468 oxyanion hole (OAH) forming residues; other site 395095001469 trimer interface [polypeptide binding]; other site 395095001470 Phenylacetic acid-responsive transcriptional repressor [Transcription]; Region: PaaX; COG3327 395095001471 PaaX-like protein; Region: PaaX; pfam07848 395095001472 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 395095001473 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 395095001474 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 395095001475 substrate binding site [chemical binding]; other site 395095001476 oxyanion hole (OAH) forming residues; other site 395095001477 trimer interface [polypeptide binding]; other site 395095001478 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 395095001479 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 395095001480 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 395095001481 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 395095001482 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 395095001483 S17 interaction site [polypeptide binding]; other site 395095001484 S8 interaction site; other site 395095001485 16S rRNA interaction site [nucleotide binding]; other site 395095001486 streptomycin interaction site [chemical binding]; other site 395095001487 23S rRNA interaction site [nucleotide binding]; other site 395095001488 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 395095001489 30S ribosomal protein S7; Validated; Region: PRK05302 395095001490 elongation factor G; Reviewed; Region: PRK00007 395095001491 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 395095001492 G1 box; other site 395095001493 putative GEF interaction site [polypeptide binding]; other site 395095001494 GTP/Mg2+ binding site [chemical binding]; other site 395095001495 Switch I region; other site 395095001496 G2 box; other site 395095001497 G3 box; other site 395095001498 Switch II region; other site 395095001499 G4 box; other site 395095001500 G5 box; other site 395095001501 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 395095001502 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 395095001503 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 395095001504 Short C-terminal domain; Region: SHOCT; pfam09851 395095001505 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 395095001506 classical (c) SDRs; Region: SDR_c; cd05233 395095001507 NAD(P) binding site [chemical binding]; other site 395095001508 active site 395095001509 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 395095001510 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 395095001511 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4427 395095001512 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 395095001513 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 395095001514 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 395095001515 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 395095001516 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 395095001517 FeS/SAM binding site; other site 395095001518 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 395095001519 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 395095001520 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 395095001521 phosphate binding site [ion binding]; other site 395095001522 mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964 395095001523 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 395095001524 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 395095001525 Probable Catalytic site; other site 395095001526 metal-binding site 395095001527 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 395095001528 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 395095001529 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 395095001530 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 395095001531 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 395095001532 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 395095001533 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 395095001534 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 395095001535 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 395095001536 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 395095001537 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 395095001538 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 395095001539 putative translocon binding site; other site 395095001540 protein-rRNA interface [nucleotide binding]; other site 395095001541 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 395095001542 23S rRNA interface [nucleotide binding]; other site 395095001543 5S rRNA interface [nucleotide binding]; other site 395095001544 putative antibiotic binding site [chemical binding]; other site 395095001545 L25 interface [polypeptide binding]; other site 395095001546 L27 interface [polypeptide binding]; other site 395095001547 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 395095001548 putative translocon interaction site; other site 395095001549 23S rRNA interface [nucleotide binding]; other site 395095001550 signal recognition particle (SRP54) interaction site; other site 395095001551 L23 interface [polypeptide binding]; other site 395095001552 trigger factor interaction site; other site 395095001553 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 395095001554 Sulfatase; Region: Sulfatase; pfam00884 395095001555 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353 395095001556 Uncharacterized conserved protein [Function unknown]; Region: COG1262 395095001557 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 395095001558 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 395095001559 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 395095001560 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 395095001561 RNA binding site [nucleotide binding]; other site 395095001562 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 395095001563 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 395095001564 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 395095001565 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 395095001566 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 395095001567 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 395095001568 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 395095001569 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 395095001570 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 395095001571 5S rRNA interface [nucleotide binding]; other site 395095001572 23S rRNA interface [nucleotide binding]; other site 395095001573 L5 interface [polypeptide binding]; other site 395095001574 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 395095001575 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 395095001576 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 395095001577 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 395095001578 23S rRNA binding site [nucleotide binding]; other site 395095001579 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 395095001580 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 395095001581 tandem repeat interface [polypeptide binding]; other site 395095001582 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 395095001583 oligomer interface [polypeptide binding]; other site 395095001584 active site residues [active] 395095001585 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 395095001586 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 395095001587 tandem repeat interface [polypeptide binding]; other site 395095001588 oligomer interface [polypeptide binding]; other site 395095001589 active site residues [active] 395095001590 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 395095001591 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 395095001592 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 395095001593 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 395095001594 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 395095001595 intersubunit interface [polypeptide binding]; other site 395095001596 active site 395095001597 Zn2+ binding site [ion binding]; other site 395095001598 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 395095001599 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 395095001600 NAD binding site [chemical binding]; other site 395095001601 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 395095001602 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 395095001603 nucleotide binding site [chemical binding]; other site 395095001604 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 395095001605 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 395095001606 Coenzyme A binding pocket [chemical binding]; other site 395095001607 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 395095001608 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 395095001609 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 395095001610 SecY translocase; Region: SecY; pfam00344 395095001611 adenylate kinase; Reviewed; Region: adk; PRK00279 395095001612 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 395095001613 AMP-binding site [chemical binding]; other site 395095001614 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 395095001615 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 395095001616 active site 395095001617 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 395095001618 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 395095001619 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 395095001620 DNA binding residues [nucleotide binding] 395095001621 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 395095001622 Putative zinc-finger; Region: zf-HC2; pfam13490 395095001623 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 395095001624 MarR family; Region: MarR; pfam01047 395095001625 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 395095001626 TIGR03086 family protein; Region: TIGR03086 395095001627 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 395095001628 Transposase; Region: DDE_Tnp_ISL3; pfam01610 395095001629 Helix-turn-helix domain; Region: HTH_17; pfam12728 395095001630 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 395095001631 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 395095001632 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 395095001633 active site 395095001634 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 395095001635 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 395095001636 tetrameric interface [polypeptide binding]; other site 395095001637 NAD binding site [chemical binding]; other site 395095001638 catalytic residues [active] 395095001639 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 395095001640 catalytic core [active] 395095001641 Helix-turn-helix domain; Region: HTH_28; pfam13518 395095001642 Winged helix-turn helix; Region: HTH_29; pfam13551 395095001643 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 395095001644 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395095001645 active site 395095001646 phosphorylation site [posttranslational modification] 395095001647 intermolecular recognition site; other site 395095001648 dimerization interface [polypeptide binding]; other site 395095001649 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 395095001650 DNA binding site [nucleotide binding] 395095001651 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 395095001652 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 395095001653 dimerization interface [polypeptide binding]; other site 395095001654 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395095001655 dimer interface [polypeptide binding]; other site 395095001656 phosphorylation site [posttranslational modification] 395095001657 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395095001658 ATP binding site [chemical binding]; other site 395095001659 Mg2+ binding site [ion binding]; other site 395095001660 G-X-G motif; other site 395095001661 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 395095001662 nucleotide binding site/active site [active] 395095001663 HIT family signature motif; other site 395095001664 catalytic residue [active] 395095001665 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 395095001666 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 395095001667 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 395095001668 NAD binding site [chemical binding]; other site 395095001669 catalytic Zn binding site [ion binding]; other site 395095001670 substrate binding site [chemical binding]; other site 395095001671 structural Zn binding site [ion binding]; other site 395095001672 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 395095001673 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 395095001674 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 395095001675 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 395095001676 Cytochrome P450; Region: p450; cl12078 395095001677 short chain dehydrogenase; Provisional; Region: PRK07775 395095001678 classical (c) SDRs; Region: SDR_c; cd05233 395095001679 NAD(P) binding site [chemical binding]; other site 395095001680 active site 395095001681 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 395095001682 Cytochrome P450; Region: p450; cl12078 395095001683 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 395095001684 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 395095001685 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 395095001686 NAD binding site [chemical binding]; other site 395095001687 catalytic residues [active] 395095001688 short chain dehydrogenase; Provisional; Region: PRK07774 395095001689 classical (c) SDRs; Region: SDR_c; cd05233 395095001690 NAD(P) binding site [chemical binding]; other site 395095001691 active site 395095001692 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 395095001693 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 395095001694 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 395095001695 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 395095001696 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 395095001697 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 395095001698 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 395095001699 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 395095001700 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 395095001701 Predicted esterase [General function prediction only]; Region: COG0627 395095001702 S-formylglutathione hydrolase; Region: PLN02442 395095001703 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 395095001704 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 395095001705 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 395095001706 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 395095001707 tetramer interface [polypeptide binding]; other site 395095001708 active site 395095001709 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 395095001710 Cytochrome P450; Region: p450; cl12078 395095001711 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 395095001712 ATP binding site [chemical binding]; other site 395095001713 active site 395095001714 substrate binding site [chemical binding]; other site 395095001715 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 395095001716 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 395095001717 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 395095001718 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 395095001719 putative substrate translocation pore; other site 395095001720 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 395095001721 Predicted deacetylase [General function prediction only]; Region: COG3233 395095001722 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 395095001723 putative active site [active] 395095001724 putative Zn binding site [ion binding]; other site 395095001725 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 395095001726 FAD binding domain; Region: FAD_binding_2; pfam00890 395095001727 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 395095001728 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 395095001729 putative active site [active] 395095001730 catalytic triad [active] 395095001731 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 395095001732 Transglutaminase/protease-like homologues; Region: TGc; smart00460 395095001733 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 395095001734 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 395095001735 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 395095001736 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 395095001737 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 395095001738 DNA-binding site [nucleotide binding]; DNA binding site 395095001739 UTRA domain; Region: UTRA; pfam07702 395095001740 Uncharacterized conserved protein [Function unknown]; Region: COG1359 395095001741 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 395095001742 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 395095001743 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 395095001744 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 395095001745 Uncharacterized protein, linocin/CFP29 homolog [Function unknown]; Region: COG1659 395095001746 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 395095001747 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 395095001748 active site 395095001749 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 395095001750 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 395095001751 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 395095001752 CAAX protease self-immunity; Region: Abi; pfam02517 395095001753 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 395095001754 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 395095001755 active site 395095001756 metal binding site [ion binding]; metal-binding site 395095001757 hexamer interface [polypeptide binding]; other site 395095001758 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 395095001759 amidophosphoribosyltransferase; Provisional; Region: PRK07847 395095001760 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 395095001761 active site 395095001762 tetramer interface [polypeptide binding]; other site 395095001763 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 395095001764 active site 395095001765 phosphoribosylaminoimidazole synthetase; Region: purM; TIGR00878 395095001766 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 395095001767 dimerization interface [polypeptide binding]; other site 395095001768 putative ATP binding site [chemical binding]; other site 395095001769 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 395095001770 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 395095001771 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 395095001772 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 395095001773 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395095001774 catalytic residue [active] 395095001775 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 395095001776 heme-binding site [chemical binding]; other site 395095001777 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 395095001778 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 395095001779 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 395095001780 active site residue [active] 395095001781 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 395095001782 active site residue [active] 395095001783 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 395095001784 catalytic residues [active] 395095001785 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 395095001786 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 395095001787 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 395095001788 DNA binding site [nucleotide binding] 395095001789 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 395095001790 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 395095001791 Coenzyme A binding pocket [chemical binding]; other site 395095001792 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 395095001793 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 395095001794 Walker A/P-loop; other site 395095001795 ATP binding site [chemical binding]; other site 395095001796 Q-loop/lid; other site 395095001797 ABC transporter signature motif; other site 395095001798 Walker B; other site 395095001799 D-loop; other site 395095001800 H-loop/switch region; other site 395095001801 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 395095001802 PhoU domain; Region: PhoU; pfam01895 395095001803 PhoU domain; Region: PhoU; pfam01895 395095001804 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 395095001805 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 395095001806 FMN binding site [chemical binding]; other site 395095001807 active site 395095001808 catalytic residues [active] 395095001809 substrate binding site [chemical binding]; other site 395095001810 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 395095001811 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 395095001812 homodimer interface [polypeptide binding]; other site 395095001813 putative substrate binding pocket [chemical binding]; other site 395095001814 diiron center [ion binding]; other site 395095001815 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 395095001816 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 395095001817 dimerization interface [polypeptide binding]; other site 395095001818 putative DNA binding site [nucleotide binding]; other site 395095001819 putative Zn2+ binding site [ion binding]; other site 395095001820 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 395095001821 dimer interface [polypeptide binding]; other site 395095001822 catalytic motif [active] 395095001823 nucleoside/Zn binding site; other site 395095001824 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 395095001825 TIGR04255 family protein; Region: sporadTIGR04255 395095001826 PknH-like extracellular domain; Region: PknH_C; pfam14032 395095001827 Predicted nucleotidyltransferase [General function prediction only]; Region: COG4849 395095001828 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4861 395095001829 Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952 395095001830 D-ala-D-ala dipeptidase; Region: Peptidase_M15; pfam01427 395095001831 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395095001832 S-adenosylmethionine binding site [chemical binding]; other site 395095001833 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 395095001834 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 395095001835 putative substrate translocation pore; other site 395095001836 Major Facilitator Superfamily; Region: MFS_1; pfam07690 395095001837 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 395095001838 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 395095001839 tetramer interface [polypeptide binding]; other site 395095001840 TPP-binding site [chemical binding]; other site 395095001841 heterodimer interface [polypeptide binding]; other site 395095001842 phosphorylation loop region [posttranslational modification] 395095001843 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 395095001844 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395095001845 active site 395095001846 phosphorylation site [posttranslational modification] 395095001847 intermolecular recognition site; other site 395095001848 dimerization interface [polypeptide binding]; other site 395095001849 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 395095001850 DNA binding residues [nucleotide binding] 395095001851 dimerization interface [polypeptide binding]; other site 395095001852 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 395095001853 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 395095001854 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 395095001855 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 395095001856 Multicopper oxidase; Region: Cu-oxidase; pfam00394 395095001857 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 395095001858 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 395095001859 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 395095001860 dimer interface [polypeptide binding]; other site 395095001861 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395095001862 catalytic residue [active] 395095001863 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 395095001864 short chain dehydrogenase; Provisional; Region: PRK05876 395095001865 classical (c) SDRs; Region: SDR_c; cd05233 395095001866 NAD(P) binding site [chemical binding]; other site 395095001867 active site 395095001868 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 395095001869 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 395095001870 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 395095001871 dimer interface [polypeptide binding]; other site 395095001872 PYR/PP interface [polypeptide binding]; other site 395095001873 TPP binding site [chemical binding]; other site 395095001874 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 395095001875 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 395095001876 TPP-binding site [chemical binding]; other site 395095001877 dimer interface [polypeptide binding]; other site 395095001878 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 395095001879 putative hydrophobic ligand binding site [chemical binding]; other site 395095001880 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 395095001881 CoA-transferase family III; Region: CoA_transf_3; pfam02515 395095001882 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 395095001883 putative hydrophobic ligand binding site [chemical binding]; other site 395095001884 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 395095001885 putative hydrophobic ligand binding site [chemical binding]; other site 395095001886 aminotransferase; Validated; Region: PRK07777 395095001887 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 395095001888 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395095001889 homodimer interface [polypeptide binding]; other site 395095001890 catalytic residue [active] 395095001891 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 395095001892 trimer interface [polypeptide binding]; other site 395095001893 dimer interface [polypeptide binding]; other site 395095001894 putative active site [active] 395095001895 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 395095001896 MPT binding site; other site 395095001897 trimer interface [polypeptide binding]; other site 395095001898 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 395095001899 MoaE homodimer interface [polypeptide binding]; other site 395095001900 MoaD interaction [polypeptide binding]; other site 395095001901 active site residues [active] 395095001902 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 395095001903 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 395095001904 MoaE interaction surface [polypeptide binding]; other site 395095001905 MoeB interaction surface [polypeptide binding]; other site 395095001906 thiocarboxylated glycine; other site 395095001907 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 395095001908 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 395095001909 FeS/SAM binding site; other site 395095001910 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 395095001911 hypothetical protein; Provisional; Region: PRK11770 395095001912 Domain of unknown function (DUF307); Region: DUF307; pfam03733 395095001913 Domain of unknown function (DUF307); Region: DUF307; pfam03733 395095001914 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 395095001915 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 395095001916 active site 395095001917 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 395095001918 FIST N domain; Region: FIST; pfam08495 395095001919 FIST C domain; Region: FIST_C; pfam10442 395095001920 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 395095001921 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 395095001922 PPE family; Region: PPE; pfam00823 395095001923 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 395095001924 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 395095001925 Protein of unknown function (DUF2530); Region: DUF2530; pfam10745 395095001926 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 395095001927 MarR family; Region: MarR; pfam01047 395095001928 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 395095001929 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 395095001930 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 395095001931 Protein of unknown function (DUF2537); Region: DUF2537; pfam10801 395095001932 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 395095001933 phosphoserine aminotransferase, putative; Region: serC_3; TIGR01366 395095001934 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 395095001935 catalytic residue [active] 395095001936 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 395095001937 Ferredoxin [Energy production and conversion]; Region: COG1146 395095001938 4Fe-4S binding domain; Region: Fer4; pfam00037 395095001939 ferredoxin-NADP+ reductase; Region: PLN02852 395095001940 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 395095001941 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 395095001942 putative dimer interface [polypeptide binding]; other site 395095001943 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 395095001944 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 395095001945 putative catalytic site [active] 395095001946 putative phosphate binding site [ion binding]; other site 395095001947 putative metal binding site [ion binding]; other site 395095001948 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 395095001949 dimer interface [polypeptide binding]; other site 395095001950 Citrate synthase; Region: Citrate_synt; pfam00285 395095001951 active site 395095001952 citrylCoA binding site [chemical binding]; other site 395095001953 oxalacetate/citrate binding site [chemical binding]; other site 395095001954 coenzyme A binding site [chemical binding]; other site 395095001955 catalytic triad [active] 395095001956 Predicted ATPase [General function prediction only]; Region: COG3903 395095001957 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 395095001958 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 395095001959 DNA binding residues [nucleotide binding] 395095001960 dimerization interface [polypeptide binding]; other site 395095001961 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 395095001962 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 395095001963 AAA ATPase domain; Region: AAA_16; pfam13191 395095001964 Predicted ATPase [General function prediction only]; Region: COG3903 395095001965 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 395095001966 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 395095001967 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 395095001968 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 395095001969 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 395095001970 BON domain; Region: BON; pfam04972 395095001971 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 395095001972 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 395095001973 ligand binding site [chemical binding]; other site 395095001974 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 395095001975 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 395095001976 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 395095001977 dimerization interface [polypeptide binding]; other site 395095001978 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395095001979 dimer interface [polypeptide binding]; other site 395095001980 phosphorylation site [posttranslational modification] 395095001981 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395095001982 Mg2+ binding site [ion binding]; other site 395095001983 G-X-G motif; other site 395095001984 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 395095001985 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395095001986 active site 395095001987 phosphorylation site [posttranslational modification] 395095001988 intermolecular recognition site; other site 395095001989 dimerization interface [polypeptide binding]; other site 395095001990 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 395095001991 DNA binding site [nucleotide binding] 395095001992 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 395095001993 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; COG0825 395095001994 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 395095001995 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 395095001996 substrate binding site [chemical binding]; other site 395095001997 oxyanion hole (OAH) forming residues; other site 395095001998 trimer interface [polypeptide binding]; other site 395095001999 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 395095002000 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 395095002001 Soluble P-type ATPase [General function prediction only]; Region: COG4087 395095002002 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 395095002003 hydrophobic ligand binding site; other site 395095002004 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 395095002005 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 395095002006 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 395095002007 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 395095002008 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 395095002009 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 395095002010 acetyl-CoA acetyltransferase; Provisional; Region: PRK06289 395095002011 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 395095002012 active site 395095002013 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 395095002014 PPE family; Region: PPE; pfam00823 395095002015 PE family; Region: PE; pfam00934 395095002016 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 395095002017 Coenzyme A binding pocket [chemical binding]; other site 395095002018 Transposase, Mutator family; Region: Transposase_mut; pfam00872 395095002019 MULE transposase domain; Region: MULE; pfam10551 395095002020 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 395095002021 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 395095002022 catalytic residues [active] 395095002023 catalytic nucleophile [active] 395095002024 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 395095002025 Probable transposase; Region: OrfB_IS605; pfam01385 395095002026 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 395095002027 putative active site pocket [active] 395095002028 dimerization interface [polypeptide binding]; other site 395095002029 putative catalytic residue [active] 395095002030 Phage-related replication protein [General function prediction only]; Region: COG4195 395095002031 manganese transport protein MntH; Reviewed; Region: PRK00701 395095002032 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 395095002033 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 395095002034 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 395095002035 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 395095002036 short chain dehydrogenase; Provisional; Region: PRK07814 395095002037 classical (c) SDRs; Region: SDR_c; cd05233 395095002038 NAD(P) binding site [chemical binding]; other site 395095002039 active site 395095002040 phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975 395095002041 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 395095002042 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395095002043 dimer interface [polypeptide binding]; other site 395095002044 conserved gate region; other site 395095002045 putative PBP binding loops; other site 395095002046 ABC-ATPase subunit interface; other site 395095002047 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 395095002048 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395095002049 dimer interface [polypeptide binding]; other site 395095002050 conserved gate region; other site 395095002051 putative PBP binding loops; other site 395095002052 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 395095002053 ABC-ATPase subunit interface; other site 395095002054 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 395095002055 Catalytic domain of Protein Kinases; Region: PKc; cd00180 395095002056 active site 395095002057 ATP binding site [chemical binding]; other site 395095002058 substrate binding site [chemical binding]; other site 395095002059 activation loop (A-loop); other site 395095002060 Uncharacterized conserved protein [Function unknown]; Region: COG3391 395095002061 NHL repeat; Region: NHL; pfam01436 395095002062 NHL repeat; Region: NHL; pfam01436 395095002063 NHL repeat; Region: NHL; pfam01436 395095002064 NHL repeat; Region: NHL; pfam01436 395095002065 NHL repeat; Region: NHL; pfam01436 395095002066 PBP superfamily domain; Region: PBP_like_2; cl17296 395095002067 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14271 395095002068 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 395095002069 Walker A/P-loop; other site 395095002070 ATP binding site [chemical binding]; other site 395095002071 Q-loop/lid; other site 395095002072 ABC transporter signature motif; other site 395095002073 Walker B; other site 395095002074 D-loop; other site 395095002075 H-loop/switch region; other site 395095002076 phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975 395095002077 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 395095002078 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395095002079 dimer interface [polypeptide binding]; other site 395095002080 conserved gate region; other site 395095002081 putative PBP binding loops; other site 395095002082 ABC-ATPase subunit interface; other site 395095002083 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 395095002084 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395095002085 dimer interface [polypeptide binding]; other site 395095002086 conserved gate region; other site 395095002087 putative PBP binding loops; other site 395095002088 ABC-ATPase subunit interface; other site 395095002089 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 395095002090 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 395095002091 nucleotide binding site [chemical binding]; other site 395095002092 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 395095002093 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 395095002094 active site 395095002095 DNA binding site [nucleotide binding] 395095002096 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 395095002097 DNA binding site [nucleotide binding] 395095002098 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 395095002099 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 395095002100 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 395095002101 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 395095002102 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 395095002103 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 395095002104 anti sigma factor interaction site; other site 395095002105 regulatory phosphorylation site [posttranslational modification]; other site 395095002106 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 395095002107 short chain dehydrogenase; Provisional; Region: PRK08251 395095002108 classical (c) SDR, subgroup 6; Region: SDR_c6; cd05350 395095002109 putative NAD(P) binding site [chemical binding]; other site 395095002110 active site 395095002111 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 395095002112 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 395095002113 active site 395095002114 dimer interface [polypeptide binding]; other site 395095002115 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 395095002116 dimer interface [polypeptide binding]; other site 395095002117 active site 395095002118 hypothetical protein; Provisional; Region: PRK07857 395095002119 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 395095002120 Peptidase family M23; Region: Peptidase_M23; pfam01551 395095002121 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 395095002122 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 395095002123 CoA-ligase; Region: Ligase_CoA; pfam00549 395095002124 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 395095002125 CoA binding domain; Region: CoA_binding; smart00881 395095002126 CoA-ligase; Region: Ligase_CoA; pfam00549 395095002127 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 395095002128 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 395095002129 active site 395095002130 substrate binding site [chemical binding]; other site 395095002131 cosubstrate binding site; other site 395095002132 catalytic site [active] 395095002133 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 395095002134 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 395095002135 purine monophosphate binding site [chemical binding]; other site 395095002136 dimer interface [polypeptide binding]; other site 395095002137 putative catalytic residues [active] 395095002138 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 395095002139 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 395095002140 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 395095002141 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 395095002142 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 395095002143 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 395095002144 metal ion-dependent adhesion site (MIDAS); other site 395095002145 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 395095002146 homotetrameric interface [polypeptide binding]; other site 395095002147 putative active site [active] 395095002148 metal binding site [ion binding]; metal-binding site 395095002149 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 395095002150 putative transposase OrfB; Reviewed; Region: PHA02517 395095002151 HTH-like domain; Region: HTH_21; pfam13276 395095002152 Integrase core domain; Region: rve; pfam00665 395095002153 Integrase core domain; Region: rve_3; pfam13683 395095002154 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 395095002155 Transposase; Region: HTH_Tnp_1; cl17663 395095002156 Thermus thermophilus CsoR, a Cu(I)-sensing transcriptional regulator, and related domains; this domain family was previously known as part of DUF156; Region: TthCsoR-like_DUF156; cd10151 395095002157 putative homodimer interface [polypeptide binding]; other site 395095002158 putative homotetramer interface [polypeptide binding]; other site 395095002159 allosteric switch controlling residues; other site 395095002160 putative metal binding site [ion binding]; other site 395095002161 putative homodimer-homodimer interface [polypeptide binding]; other site 395095002162 enoyl-CoA hydratase; Provisional; Region: PRK07827 395095002163 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 395095002164 substrate binding site [chemical binding]; other site 395095002165 oxyanion hole (OAH) forming residues; other site 395095002166 trimer interface [polypeptide binding]; other site 395095002167 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 395095002168 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 395095002169 active site 395095002170 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 395095002171 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 395095002172 ATP-grasp domain; Region: ATP-grasp_4; cl17255 395095002173 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 395095002174 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 395095002175 carboxyltransferase (CT) interaction site; other site 395095002176 biotinylation site [posttranslational modification]; other site 395095002177 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 395095002178 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 395095002179 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 395095002180 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 395095002181 active site 395095002182 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 395095002183 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395095002184 active site 395095002185 phosphorylation site [posttranslational modification] 395095002186 intermolecular recognition site; other site 395095002187 dimerization interface [polypeptide binding]; other site 395095002188 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 395095002189 DNA binding site [nucleotide binding] 395095002190 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 395095002191 MPT binding site; other site 395095002192 trimer interface [polypeptide binding]; other site 395095002193 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 395095002194 Large-conductance mechanosensitive channel, MscL; Region: MscL; pfam01741 395095002195 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 395095002196 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 395095002197 Walker A/P-loop; other site 395095002198 ATP binding site [chemical binding]; other site 395095002199 Q-loop/lid; other site 395095002200 ABC transporter signature motif; other site 395095002201 Walker B; other site 395095002202 D-loop; other site 395095002203 H-loop/switch region; other site 395095002204 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 395095002205 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 395095002206 substrate binding pocket [chemical binding]; other site 395095002207 chain length determination region; other site 395095002208 substrate-Mg2+ binding site; other site 395095002209 catalytic residues [active] 395095002210 aspartate-rich region 1; other site 395095002211 active site lid residues [active] 395095002212 aspartate-rich region 2; other site 395095002213 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 395095002214 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 395095002215 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 395095002216 active site 395095002217 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 395095002218 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 395095002219 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 395095002220 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 395095002221 ligand binding site [chemical binding]; other site 395095002222 flexible hinge region; other site 395095002223 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 395095002224 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 395095002225 Coenzyme A binding pocket [chemical binding]; other site 395095002226 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 395095002227 arginine deiminase; Provisional; Region: PRK01388 395095002228 Predicted methyltransferases [General function prediction only]; Region: COG0313 395095002229 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 395095002230 putative SAM binding site [chemical binding]; other site 395095002231 putative homodimer interface [polypeptide binding]; other site 395095002232 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 395095002233 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 395095002234 active site 395095002235 HIGH motif; other site 395095002236 KMSKS motif; other site 395095002237 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 395095002238 tRNA binding surface [nucleotide binding]; other site 395095002239 anticodon binding site; other site 395095002240 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 395095002241 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 395095002242 active site 395095002243 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 395095002244 Domain of unknown function (DUF348); Region: DUF348; pfam03990 395095002245 Domain of unknown function (DUF348); Region: DUF348; pfam03990 395095002246 G5 domain; Region: G5; pfam07501 395095002247 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 395095002248 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 395095002249 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395095002250 S-adenosylmethionine binding site [chemical binding]; other site 395095002251 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 395095002252 Increased loss of mitochondrial DNA protein 1; Region: Ilm1; pfam10311 395095002253 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 395095002254 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 395095002255 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 395095002256 acyl-activating enzyme (AAE) consensus motif; other site 395095002257 AMP binding site [chemical binding]; other site 395095002258 active site 395095002259 CoA binding site [chemical binding]; other site 395095002260 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 395095002261 putative active site [active] 395095002262 catalytic residue [active] 395095002263 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 395095002264 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 395095002265 5S rRNA interface [nucleotide binding]; other site 395095002266 CTC domain interface [polypeptide binding]; other site 395095002267 L16 interface [polypeptide binding]; other site 395095002268 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 395095002269 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 395095002270 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 395095002271 active site 395095002272 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 395095002273 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 395095002274 Substrate binding site; other site 395095002275 Mg++ binding site; other site 395095002276 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 395095002277 active site 395095002278 substrate binding site [chemical binding]; other site 395095002279 CoA binding site [chemical binding]; other site 395095002280 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 395095002281 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 395095002282 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 395095002283 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 395095002284 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 395095002285 ATP binding site [chemical binding]; other site 395095002286 putative Mg++ binding site [ion binding]; other site 395095002287 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 395095002288 nucleotide binding region [chemical binding]; other site 395095002289 ATP-binding site [chemical binding]; other site 395095002290 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 395095002291 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 395095002292 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 395095002293 homodimer interface [polypeptide binding]; other site 395095002294 metal binding site [ion binding]; metal-binding site 395095002295 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 395095002296 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 395095002297 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 395095002298 N-acetyl-D-glucosamine binding site [chemical binding]; other site 395095002299 enolase; Provisional; Region: eno; PRK00077 395095002300 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 395095002301 dimer interface [polypeptide binding]; other site 395095002302 metal binding site [ion binding]; metal-binding site 395095002303 substrate binding pocket [chemical binding]; other site 395095002304 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 395095002305 Septum formation initiator; Region: DivIC; pfam04977 395095002306 Uncharacterized conserved protein [Function unknown]; Region: COG1507 395095002307 exopolyphosphatase; Region: exo_poly_only; TIGR03706 395095002308 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 395095002309 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 395095002310 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 395095002311 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 395095002312 Ligand Binding Site [chemical binding]; other site 395095002313 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395095002314 dimer interface [polypeptide binding]; other site 395095002315 phosphorylation site [posttranslational modification] 395095002316 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395095002317 ATP binding site [chemical binding]; other site 395095002318 Mg2+ binding site [ion binding]; other site 395095002319 G-X-G motif; other site 395095002320 K+-transporting ATPase, KdpA; Region: kdpA; TIGR00680 395095002321 potassium-transporting ATPase subunit C; Provisional; Region: PRK14001 395095002322 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 395095002323 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395095002324 dimer interface [polypeptide binding]; other site 395095002325 phosphorylation site [posttranslational modification] 395095002326 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395095002327 ATP binding site [chemical binding]; other site 395095002328 Mg2+ binding site [ion binding]; other site 395095002329 G-X-G motif; other site 395095002330 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 395095002331 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395095002332 active site 395095002333 phosphorylation site [posttranslational modification] 395095002334 intermolecular recognition site; other site 395095002335 dimerization interface [polypeptide binding]; other site 395095002336 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 395095002337 DNA binding site [nucleotide binding] 395095002338 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 395095002339 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 395095002340 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 395095002341 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 395095002342 PPE family; Region: PPE; pfam00823 395095002343 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 395095002344 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 395095002345 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 395095002346 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 395095002347 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 395095002348 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 395095002349 Predicted transcriptional regulator [Transcription]; Region: COG5340 395095002350 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 395095002351 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 395095002352 Transcriptional regulators [Transcription]; Region: MarR; COG1846 395095002353 MarR family; Region: MarR_2; pfam12802 395095002354 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395095002355 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 395095002356 NAD(P) binding site [chemical binding]; other site 395095002357 active site 395095002358 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 395095002359 Helix-turn-helix domain; Region: HTH_17; pfam12728 395095002360 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 395095002361 Domain of unknown function (DUF427); Region: DUF427; cl00998 395095002362 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 395095002363 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 395095002364 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 395095002365 dimer interface [polypeptide binding]; other site 395095002366 acyl-activating enzyme (AAE) consensus motif; other site 395095002367 putative active site [active] 395095002368 AMP binding site [chemical binding]; other site 395095002369 putative CoA binding site [chemical binding]; other site 395095002370 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 395095002371 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 395095002372 hydrophobic ligand binding site; other site 395095002373 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 395095002374 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 395095002375 putative active site [active] 395095002376 putative dimer interface [polypeptide binding]; other site 395095002377 Predicted membrane protein [Function unknown]; Region: COG4425 395095002378 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 395095002379 enoyl-CoA hydratase; Provisional; Region: PRK05862 395095002380 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 395095002381 substrate binding site [chemical binding]; other site 395095002382 oxyanion hole (OAH) forming residues; other site 395095002383 trimer interface [polypeptide binding]; other site 395095002384 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 395095002385 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 395095002386 substrate binding site [chemical binding]; other site 395095002387 oxyanion hole (OAH) forming residues; other site 395095002388 trimer interface [polypeptide binding]; other site 395095002389 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 395095002390 Predicted membrane protein [Function unknown]; Region: COG4760 395095002391 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 395095002392 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 395095002393 dimer interface [polypeptide binding]; other site 395095002394 active site 395095002395 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 395095002396 active site 395095002397 catalytic triad [active] 395095002398 oxyanion hole [active] 395095002399 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 395095002400 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 395095002401 dimer interface [polypeptide binding]; other site 395095002402 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395095002403 catalytic residue [active] 395095002404 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 395095002405 cystathionine gamma-synthase; Provisional; Region: PRK07811 395095002406 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 395095002407 homodimer interface [polypeptide binding]; other site 395095002408 substrate-cofactor binding pocket; other site 395095002409 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395095002410 catalytic residue [active] 395095002411 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 395095002412 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 395095002413 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 395095002414 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 395095002415 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 395095002416 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 395095002417 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 395095002418 putative IPP diphosphate binding site; other site 395095002419 PE family; Region: PE; pfam00934 395095002420 Glycosyl hydrolase family 12; Region: Glyco_hydro_12; pfam01670 395095002421 pantothenate kinase; Provisional; Region: PRK05439 395095002422 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 395095002423 ATP-binding site [chemical binding]; other site 395095002424 CoA-binding site [chemical binding]; other site 395095002425 Mg2+-binding site [ion binding]; other site 395095002426 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 395095002427 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 395095002428 dimer interface [polypeptide binding]; other site 395095002429 active site 395095002430 glycine-pyridoxal phosphate binding site [chemical binding]; other site 395095002431 folate binding site [chemical binding]; other site 395095002432 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 395095002433 dinuclear metal binding motif [ion binding]; other site 395095002434 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 395095002435 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 395095002436 putative active site [active] 395095002437 PhoH-like protein; Region: PhoH; pfam02562 395095002438 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 395095002439 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 395095002440 NodB motif; other site 395095002441 active site 395095002442 catalytic site [active] 395095002443 metal binding site [ion binding]; metal-binding site 395095002444 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 395095002445 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 395095002446 Domain of unknown function DUF20; Region: UPF0118; pfam01594 395095002447 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 395095002448 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 395095002449 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 395095002450 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 395095002451 3beta-hydroxysteroid dehydrogenases (3b-HSD)-like, extended (e) SDRs; Region: 3b-HSD-like_SDR_e; cd05241 395095002452 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 395095002453 putative NAD(P) binding site [chemical binding]; other site 395095002454 active site 395095002455 putative substrate binding site [chemical binding]; other site 395095002456 exodeoxyribonuclease VII, small subunit; Region: xseB; TIGR01280 395095002457 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 395095002458 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 395095002459 generic binding surface II; other site 395095002460 generic binding surface I; other site 395095002461 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 395095002462 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 395095002463 Yip1 domain; Region: Yip1; pfam04893 395095002464 GTP-binding protein YchF; Reviewed; Region: PRK09601 395095002465 YchF GTPase; Region: YchF; cd01900 395095002466 G1 box; other site 395095002467 GTP/Mg2+ binding site [chemical binding]; other site 395095002468 Switch I region; other site 395095002469 G2 box; other site 395095002470 Switch II region; other site 395095002471 G3 box; other site 395095002472 G4 box; other site 395095002473 G5 box; other site 395095002474 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 395095002475 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487 395095002476 putative active site [active] 395095002477 Uncharacterized conserved protein [Function unknown]; Region: COG1359 395095002478 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 395095002479 cyclase homology domain; Region: CHD; cd07302 395095002480 nucleotidyl binding site; other site 395095002481 metal binding site [ion binding]; metal-binding site 395095002482 dimer interface [polypeptide binding]; other site 395095002483 glucose-6-phosphate 1-dehydrogenase; Region: zwf; TIGR00871 395095002484 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 395095002485 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 395095002486 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 395095002487 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd_rel; TIGR00872 395095002488 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 395095002489 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 395095002490 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 395095002491 pyruvate phosphate dikinase; Provisional; Region: PRK05878 395095002492 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 395095002493 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 395095002494 Domain of unknown function (DUF222); Region: DUF222; pfam02720 395095002495 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 395095002496 active site 395095002497 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 395095002498 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 395095002499 non-specific DNA binding site [nucleotide binding]; other site 395095002500 salt bridge; other site 395095002501 sequence-specific DNA binding site [nucleotide binding]; other site 395095002502 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 395095002503 Domain of unknown function (DUF955); Region: DUF955; pfam06114 395095002504 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 395095002505 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 395095002506 citrate synthase; Provisional; Region: PRK14033 395095002507 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 395095002508 oxalacetate binding site [chemical binding]; other site 395095002509 citrylCoA binding site [chemical binding]; other site 395095002510 coenzyme A binding site [chemical binding]; other site 395095002511 catalytic triad [active] 395095002512 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 395095002513 PPE family; Region: PPE; pfam00823 395095002514 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 395095002515 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 395095002516 active site 395095002517 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 395095002518 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 395095002519 substrate binding site [chemical binding]; other site 395095002520 oxyanion hole (OAH) forming residues; other site 395095002521 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 395095002522 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 395095002523 CAAX protease self-immunity; Region: Abi; pfam02517 395095002524 enoyl-CoA hydratase; Provisional; Region: PRK06688 395095002525 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 395095002526 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 395095002527 trimer interface [polypeptide binding]; other site 395095002528 enoyl-CoA hydratase; Provisional; Region: PRK06688 395095002529 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 395095002530 substrate binding site [chemical binding]; other site 395095002531 oxyanion hole (OAH) forming residues; other site 395095002532 trimer interface [polypeptide binding]; other site 395095002533 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 395095002534 CoA-transferase family III; Region: CoA_transf_3; pfam02515 395095002535 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 395095002536 NAD binding site [chemical binding]; other site 395095002537 homodimer interface [polypeptide binding]; other site 395095002538 homotetramer interface [polypeptide binding]; other site 395095002539 active site 395095002540 NAD-dependent deacetylase; Provisional; Region: PRK00481 395095002541 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 395095002542 NAD+ binding site [chemical binding]; other site 395095002543 substrate binding site [chemical binding]; other site 395095002544 Zn binding site [ion binding]; other site 395095002545 Predicted transcriptional regulators [Transcription]; Region: COG1725 395095002546 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 395095002547 DNA-binding site [nucleotide binding]; DNA binding site 395095002548 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 395095002549 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 395095002550 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 395095002551 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 395095002552 uncharacterized HhH-GPD family protein; Region: TIGR03252 395095002553 minor groove reading motif; other site 395095002554 helix-hairpin-helix signature motif; other site 395095002555 mannosyltransferase; Provisional; Region: pimE; PRK13375 395095002556 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 395095002557 aromatic arch; other site 395095002558 DCoH dimer interaction site [polypeptide binding]; other site 395095002559 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 395095002560 DCoH tetramer interaction site [polypeptide binding]; other site 395095002561 substrate binding site [chemical binding]; other site 395095002562 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 395095002563 active site 395095002564 8-oxo-dGMP binding site [chemical binding]; other site 395095002565 nudix motif; other site 395095002566 metal binding site [ion binding]; metal-binding site 395095002567 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 395095002568 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 395095002569 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 395095002570 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 395095002571 G1 box; other site 395095002572 putative GEF interaction site [polypeptide binding]; other site 395095002573 GTP/Mg2+ binding site [chemical binding]; other site 395095002574 Switch I region; other site 395095002575 G2 box; other site 395095002576 G3 box; other site 395095002577 Switch II region; other site 395095002578 G4 box; other site 395095002579 G5 box; other site 395095002580 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 395095002581 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 395095002582 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 395095002583 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 395095002584 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 395095002585 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 395095002586 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 395095002587 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 395095002588 PPE family; Region: PPE; pfam00823 395095002589 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 395095002590 PE family; Region: PE; pfam00934 395095002591 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 395095002592 PE family; Region: PE; pfam00934 395095002593 FO synthase; Reviewed; Region: fbiC; PRK09234 395095002594 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 395095002595 FeS/SAM binding site; other site 395095002596 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 395095002597 FeS/SAM binding site; other site 395095002598 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 395095002599 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 395095002600 active site 395095002601 FMN binding site [chemical binding]; other site 395095002602 2,4-decadienoyl-CoA binding site; other site 395095002603 catalytic residue [active] 395095002604 4Fe-4S cluster binding site [ion binding]; other site 395095002605 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 395095002606 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 395095002607 Predicted transcriptional regulators [Transcription]; Region: COG1695 395095002608 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 395095002609 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 395095002610 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 395095002611 4Fe-4S binding domain; Region: Fer4; pfam00037 395095002612 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 395095002613 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 395095002614 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395095002615 homodimer interface [polypeptide binding]; other site 395095002616 catalytic residue [active] 395095002617 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 395095002618 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 395095002619 PE-PPE domain; Region: PE-PPE; pfam08237 395095002620 acyl-CoA synthetase; Validated; Region: PRK05850 395095002621 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 395095002622 acyl-activating enzyme (AAE) consensus motif; other site 395095002623 active site 395095002624 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 395095002625 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 395095002626 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 395095002627 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 395095002628 Glutamate binding site [chemical binding]; other site 395095002629 NAD binding site [chemical binding]; other site 395095002630 catalytic residues [active] 395095002631 Proline dehydrogenase; Region: Pro_dh; pfam01619 395095002632 RNA polymerase sigma factor SigI; Provisional; Region: sigI; PRK09635 395095002633 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 395095002634 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 395095002635 DNA binding residues [nucleotide binding] 395095002636 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 395095002637 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 395095002638 acyl-CoA synthetase; Validated; Region: PRK07787 395095002639 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 395095002640 acyl-activating enzyme (AAE) consensus motif; other site 395095002641 AMP binding site [chemical binding]; other site 395095002642 active site 395095002643 CoA binding site [chemical binding]; other site 395095002644 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 395095002645 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 395095002646 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 395095002647 PPE family; Region: PPE; pfam00823 395095002648 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 395095002649 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 395095002650 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 395095002651 metabolite-proton symporter; Region: 2A0106; TIGR00883 395095002652 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 395095002653 putative substrate translocation pore; other site 395095002654 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 395095002655 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 395095002656 putative trimer interface [polypeptide binding]; other site 395095002657 putative CoA binding site [chemical binding]; other site 395095002658 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 395095002659 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 395095002660 metal binding site [ion binding]; metal-binding site 395095002661 putative dimer interface [polypeptide binding]; other site 395095002662 TIGR00730 family protein; Region: TIGR00730 395095002663 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 395095002664 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 395095002665 DivIVA domain; Region: DivI1A_domain; TIGR03544 395095002666 DNA-3-methyladenine glycosylase I; Region: tag; TIGR00624 395095002667 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 395095002668 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 395095002669 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 395095002670 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 395095002671 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 395095002672 ligand binding site; other site 395095002673 oligomer interface; other site 395095002674 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 395095002675 dimer interface [polypeptide binding]; other site 395095002676 N-terminal domain interface [polypeptide binding]; other site 395095002677 sulfate 1 binding site; other site 395095002678 PE family; Region: PE; pfam00934 395095002679 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 395095002680 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 395095002681 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 395095002682 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 395095002683 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 395095002684 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 395095002685 Walker A/P-loop; other site 395095002686 ATP binding site [chemical binding]; other site 395095002687 Q-loop/lid; other site 395095002688 ABC transporter signature motif; other site 395095002689 Walker B; other site 395095002690 D-loop; other site 395095002691 H-loop/switch region; other site 395095002692 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 395095002693 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 395095002694 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 395095002695 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 395095002696 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 395095002697 DNA binding residues [nucleotide binding] 395095002698 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 395095002699 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 395095002700 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 395095002701 protein binding site [polypeptide binding]; other site 395095002702 sec-independent translocase; Provisional; Region: PRK03100 395095002703 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 395095002704 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 395095002705 active site 395095002706 motif I; other site 395095002707 motif II; other site 395095002708 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 395095002709 Uncharacterized conserved protein [Function unknown]; Region: COG3402 395095002710 Domain of unknown function DUF59; Region: DUF59; cl00941 395095002711 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 395095002712 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 395095002713 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 395095002714 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 395095002715 N-acetyl-D-glucosamine binding site [chemical binding]; other site 395095002716 catalytic residue [active] 395095002717 Predicted membrane protein [Function unknown]; Region: COG4420 395095002718 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 395095002719 MgtE intracellular N domain; Region: MgtE_N; smart00924 395095002720 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 395095002721 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 395095002722 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 395095002723 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395095002724 dimer interface [polypeptide binding]; other site 395095002725 conserved gate region; other site 395095002726 putative PBP binding loops; other site 395095002727 ABC-ATPase subunit interface; other site 395095002728 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 395095002729 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395095002730 dimer interface [polypeptide binding]; other site 395095002731 conserved gate region; other site 395095002732 ABC-ATPase subunit interface; other site 395095002733 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 395095002734 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 395095002735 Walker A/P-loop; other site 395095002736 ATP binding site [chemical binding]; other site 395095002737 Q-loop/lid; other site 395095002738 ABC transporter signature motif; other site 395095002739 Walker B; other site 395095002740 D-loop; other site 395095002741 H-loop/switch region; other site 395095002742 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 395095002743 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 395095002744 oligomer interface [polypeptide binding]; other site 395095002745 metal binding site [ion binding]; metal-binding site 395095002746 metal binding site [ion binding]; metal-binding site 395095002747 putative Cl binding site [ion binding]; other site 395095002748 basic sphincter; other site 395095002749 hydrophobic gate; other site 395095002750 periplasmic entrance; other site 395095002751 malate dehydrogenase; Provisional; Region: PRK05442 395095002752 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 395095002753 NAD(P) binding site [chemical binding]; other site 395095002754 dimer interface [polypeptide binding]; other site 395095002755 malate binding site [chemical binding]; other site 395095002756 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 395095002757 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 395095002758 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 395095002759 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395095002760 NAD(P) binding site [chemical binding]; other site 395095002761 active site 395095002762 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 395095002763 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 395095002764 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 395095002765 putative substrate translocation pore; other site 395095002766 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 395095002767 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 395095002768 RNase_H superfamily; Region: RNase_H_2; pfam13482 395095002769 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 395095002770 Part of AAA domain; Region: AAA_19; pfam13245 395095002771 AAA domain; Region: AAA_12; pfam13087 395095002772 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 395095002773 Acyltransferase family; Region: Acyl_transf_3; pfam01757 395095002774 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 395095002775 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 395095002776 FAD binding domain; Region: FAD_binding_4; pfam01565 395095002777 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 395095002778 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 395095002779 H+ Antiporter protein; Region: 2A0121; TIGR00900 395095002780 putative substrate translocation pore; other site 395095002781 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 395095002782 Fe-S cluster binding site [ion binding]; other site 395095002783 DNA binding site [nucleotide binding] 395095002784 active site 395095002785 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 395095002786 HIT family signature motif; other site 395095002787 catalytic residue [active] 395095002788 amidase; Provisional; Region: PRK12470 395095002789 Amidase; Region: Amidase; pfam01425 395095002790 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 395095002791 cyclase homology domain; Region: CHD; cd07302 395095002792 nucleotidyl binding site; other site 395095002793 metal binding site [ion binding]; metal-binding site 395095002794 dimer interface [polypeptide binding]; other site 395095002795 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 395095002796 Catalytic domain of Protein Kinases; Region: PKc; cd00180 395095002797 active site 395095002798 ATP binding site [chemical binding]; other site 395095002799 substrate binding site [chemical binding]; other site 395095002800 activation loop (A-loop); other site 395095002801 PknH-like extracellular domain; Region: PknH_C; pfam14032 395095002802 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 395095002803 putative active site [active] 395095002804 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 395095002805 Protein of unknown function (DUF732); Region: DUF732; pfam05305 395095002806 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 395095002807 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 395095002808 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 395095002809 Walker A/P-loop; other site 395095002810 ATP binding site [chemical binding]; other site 395095002811 Q-loop/lid; other site 395095002812 ABC transporter signature motif; other site 395095002813 Walker B; other site 395095002814 D-loop; other site 395095002815 H-loop/switch region; other site 395095002816 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 395095002817 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 395095002818 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 395095002819 Walker A/P-loop; other site 395095002820 ATP binding site [chemical binding]; other site 395095002821 Q-loop/lid; other site 395095002822 ABC transporter signature motif; other site 395095002823 Walker B; other site 395095002824 D-loop; other site 395095002825 H-loop/switch region; other site 395095002826 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 395095002827 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 395095002828 catalytic core [active] 395095002829 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 395095002830 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 395095002831 active site 395095002832 metal binding site [ion binding]; metal-binding site 395095002833 DNA binding site [nucleotide binding] 395095002834 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 395095002835 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 395095002836 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 395095002837 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 395095002838 Walker A/P-loop; other site 395095002839 ATP binding site [chemical binding]; other site 395095002840 Q-loop/lid; other site 395095002841 ABC transporter signature motif; other site 395095002842 Walker B; other site 395095002843 D-loop; other site 395095002844 H-loop/switch region; other site 395095002845 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 395095002846 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 395095002847 Walker A/P-loop; other site 395095002848 ATP binding site [chemical binding]; other site 395095002849 Q-loop/lid; other site 395095002850 ABC transporter signature motif; other site 395095002851 Walker B; other site 395095002852 D-loop; other site 395095002853 H-loop/switch region; other site 395095002854 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 395095002855 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 395095002856 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395095002857 dimer interface [polypeptide binding]; other site 395095002858 conserved gate region; other site 395095002859 putative PBP binding loops; other site 395095002860 ABC-ATPase subunit interface; other site 395095002861 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 395095002862 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395095002863 dimer interface [polypeptide binding]; other site 395095002864 conserved gate region; other site 395095002865 putative PBP binding loops; other site 395095002866 ABC-ATPase subunit interface; other site 395095002867 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 395095002868 active site clefts [active] 395095002869 zinc binding site [ion binding]; other site 395095002870 dimer interface [polypeptide binding]; other site 395095002871 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 395095002872 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 395095002873 Active Sites [active] 395095002874 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 395095002875 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 395095002876 CysD dimerization site [polypeptide binding]; other site 395095002877 G1 box; other site 395095002878 putative GEF interaction site [polypeptide binding]; other site 395095002879 GTP/Mg2+ binding site [chemical binding]; other site 395095002880 Switch I region; other site 395095002881 G2 box; other site 395095002882 G3 box; other site 395095002883 Switch II region; other site 395095002884 G4 box; other site 395095002885 G5 box; other site 395095002886 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 395095002887 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 395095002888 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 395095002889 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 395095002890 Walker A/P-loop; other site 395095002891 ligand-binding site [chemical binding]; other site 395095002892 ATP binding site [chemical binding]; other site 395095002893 Rrf2 family protein; Region: rrf2_super; TIGR00738 395095002894 Transcriptional regulator; Region: Rrf2; pfam02082 395095002895 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 395095002896 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 395095002897 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 395095002898 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 395095002899 Putative esterase; Region: Esterase; pfam00756 395095002900 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 395095002901 Predicted membrane protein [Function unknown]; Region: COG4325 395095002902 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 395095002903 Protein of unknown function (DUF732); Region: DUF732; pfam05305 395095002904 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 395095002905 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 395095002906 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 395095002907 active site 395095002908 HIGH motif; other site 395095002909 KMSK motif region; other site 395095002910 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 395095002911 tRNA binding surface [nucleotide binding]; other site 395095002912 anticodon binding site; other site 395095002913 diaminopimelate decarboxylase; Region: lysA; TIGR01048 395095002914 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 395095002915 active site 395095002916 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 395095002917 substrate binding site [chemical binding]; other site 395095002918 catalytic residues [active] 395095002919 dimer interface [polypeptide binding]; other site 395095002920 homoserine dehydrogenase; Provisional; Region: PRK06349 395095002921 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 395095002922 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 395095002923 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 395095002924 threonine synthase; Reviewed; Region: PRK06721 395095002925 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 395095002926 homodimer interface [polypeptide binding]; other site 395095002927 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395095002928 catalytic residue [active] 395095002929 Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083 395095002930 transcription termination factor Rho; Provisional; Region: PRK12678 395095002931 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 395095002932 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 395095002933 RNA binding site [nucleotide binding]; other site 395095002934 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 395095002935 multimer interface [polypeptide binding]; other site 395095002936 Walker A motif; other site 395095002937 ATP binding site [chemical binding]; other site 395095002938 Walker B motif; other site 395095002939 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 395095002940 peptide chain release factor 1; Region: prfA; TIGR00019 395095002941 This domain is found in peptide chain release factors; Region: PCRF; smart00937 395095002942 RF-1 domain; Region: RF-1; pfam00472 395095002943 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 395095002944 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395095002945 S-adenosylmethionine binding site [chemical binding]; other site 395095002946 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 395095002947 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 395095002948 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 395095002949 Mg++ binding site [ion binding]; other site 395095002950 putative catalytic motif [active] 395095002951 substrate binding site [chemical binding]; other site 395095002952 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 395095002953 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 395095002954 F0F1 ATP synthase subunit C; Validated; Region: PRK05880 395095002955 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 395095002956 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 395095002957 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13428 395095002958 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 395095002959 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 395095002960 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 395095002961 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 395095002962 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 395095002963 Walker A motif; other site 395095002964 ATP binding site [chemical binding]; other site 395095002965 Walker B motif; other site 395095002966 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 395095002967 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 395095002968 core domain interface [polypeptide binding]; other site 395095002969 delta subunit interface [polypeptide binding]; other site 395095002970 epsilon subunit interface [polypeptide binding]; other site 395095002971 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 395095002972 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 395095002973 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 395095002974 alpha subunit interaction interface [polypeptide binding]; other site 395095002975 Walker A motif; other site 395095002976 ATP binding site [chemical binding]; other site 395095002977 Walker B motif; other site 395095002978 inhibitor binding site; inhibition site 395095002979 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 395095002980 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 395095002981 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 395095002982 Transposase; Region: DDE_Tnp_ISL3; pfam01610 395095002983 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 395095002984 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 395095002985 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 395095002986 hinge; other site 395095002987 active site 395095002988 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 395095002989 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 395095002990 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 395095002991 DNA binding site [nucleotide binding] 395095002992 active site 395095002993 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 395095002994 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 395095002995 AlkA N-terminal domain; Region: AlkA_N; pfam06029 395095002996 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 395095002997 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 395095002998 minor groove reading motif; other site 395095002999 helix-hairpin-helix signature motif; other site 395095003000 substrate binding pocket [chemical binding]; other site 395095003001 active site 395095003002 HAMP domain; Region: HAMP; pfam00672 395095003003 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 395095003004 cyclase homology domain; Region: CHD; cd07302 395095003005 nucleotidyl binding site; other site 395095003006 metal binding site [ion binding]; metal-binding site 395095003007 dimer interface [polypeptide binding]; other site 395095003008 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 395095003009 dimerization interface [polypeptide binding]; other site 395095003010 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 395095003011 cyclase homology domain; Region: CHD; cd07302 395095003012 nucleotidyl binding site; other site 395095003013 metal binding site [ion binding]; metal-binding site 395095003014 dimer interface [polypeptide binding]; other site 395095003015 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 395095003016 dimerization interface [polypeptide binding]; other site 395095003017 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 395095003018 cyclase homology domain; Region: CHD; cd07302 395095003019 nucleotidyl binding site; other site 395095003020 metal binding site [ion binding]; metal-binding site 395095003021 dimer interface [polypeptide binding]; other site 395095003022 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 395095003023 hypothetical protein; Provisional; Region: PRK03298 395095003024 putative acyltransferase; Provisional; Region: PRK05790 395095003025 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 395095003026 dimer interface [polypeptide binding]; other site 395095003027 active site 395095003028 glycogen branching enzyme; Provisional; Region: PRK05402 395095003029 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 395095003030 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 395095003031 active site 395095003032 catalytic site [active] 395095003033 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 395095003034 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 395095003035 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 395095003036 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 395095003037 active site 395095003038 homodimer interface [polypeptide binding]; other site 395095003039 catalytic site [active] 395095003040 acceptor binding site [chemical binding]; other site 395095003041 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 395095003042 putative homodimer interface [polypeptide binding]; other site 395095003043 putative active site pocket [active] 395095003044 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 395095003045 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 395095003046 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 395095003047 active site 395095003048 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 395095003049 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 395095003050 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 395095003051 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 395095003052 putative active site pocket [active] 395095003053 cleavage site 395095003054 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 395095003055 MPN+ (JAMM) motif; other site 395095003056 Zinc-binding site [ion binding]; other site 395095003057 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 395095003058 MoaE interaction surface [polypeptide binding]; other site 395095003059 MoeB interaction surface [polypeptide binding]; other site 395095003060 thiocarboxylated glycine; other site 395095003061 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 395095003062 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 395095003063 dimer interface [polypeptide binding]; other site 395095003064 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395095003065 catalytic residue [active] 395095003066 Rhomboid family; Region: Rhomboid; pfam01694 395095003067 glutamate racemase; Provisional; Region: PRK00865 395095003068 ribonuclease PH; Reviewed; Region: rph; PRK00173 395095003069 Ribonuclease PH; Region: RNase_PH_bact; cd11362 395095003070 hexamer interface [polypeptide binding]; other site 395095003071 active site 395095003072 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 395095003073 active site 395095003074 dimerization interface [polypeptide binding]; other site 395095003075 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 395095003076 Glucitol operon activator [Transcription]; Region: GutM; COG4578 395095003077 acyl carrier protein; Validated; Region: PRK05883 395095003078 long-chain-fatty-acid--[acyl-carrier-protein] ligase; Validated; Region: PRK05851 395095003079 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 395095003080 acyl-activating enzyme (AAE) consensus motif; other site 395095003081 active site 395095003082 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 395095003083 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 395095003084 active site 395095003085 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 395095003086 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 395095003087 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 395095003088 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 395095003089 FAD binding pocket [chemical binding]; other site 395095003090 FAD binding motif [chemical binding]; other site 395095003091 phosphate binding motif [ion binding]; other site 395095003092 NAD binding pocket [chemical binding]; other site 395095003093 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 395095003094 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 395095003095 Walker A/P-loop; other site 395095003096 ATP binding site [chemical binding]; other site 395095003097 Q-loop/lid; other site 395095003098 ABC transporter signature motif; other site 395095003099 Walker B; other site 395095003100 D-loop; other site 395095003101 H-loop/switch region; other site 395095003102 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 395095003103 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 395095003104 Walker A/P-loop; other site 395095003105 ATP binding site [chemical binding]; other site 395095003106 Q-loop/lid; other site 395095003107 ABC transporter signature motif; other site 395095003108 Walker B; other site 395095003109 D-loop; other site 395095003110 H-loop/switch region; other site 395095003111 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 395095003112 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395095003113 NAD(P) binding site [chemical binding]; other site 395095003114 active site 395095003115 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 395095003116 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 395095003117 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 395095003118 cyclase homology domain; Region: CHD; cd07302 395095003119 nucleotidyl binding site; other site 395095003120 dimer interface [polypeptide binding]; other site 395095003121 metal binding site [ion binding]; metal-binding site 395095003122 AAA ATPase domain; Region: AAA_16; pfam13191 395095003123 Predicted ATPase [General function prediction only]; Region: COG3903 395095003124 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 395095003125 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 395095003126 DNA binding residues [nucleotide binding] 395095003127 dimerization interface [polypeptide binding]; other site 395095003128 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 395095003129 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 395095003130 PAS fold; Region: PAS_4; pfam08448 395095003131 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395095003132 putative active site [active] 395095003133 heme pocket [chemical binding]; other site 395095003134 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 395095003135 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 395095003136 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 395095003137 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 395095003138 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 395095003139 anti sigma factor interaction site; other site 395095003140 regulatory phosphorylation site [posttranslational modification]; other site 395095003141 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 395095003142 anti sigma factor interaction site; other site 395095003143 regulatory phosphorylation site [posttranslational modification]; other site 395095003144 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 395095003145 synthetase active site [active] 395095003146 NTP binding site [chemical binding]; other site 395095003147 metal binding site [ion binding]; metal-binding site 395095003148 Beta-lactamase; Region: Beta-lactamase; pfam00144 395095003149 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 395095003150 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 395095003151 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; pfam00173 395095003152 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 395095003153 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 395095003154 putative di-iron ligands [ion binding]; other site 395095003155 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 395095003156 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 395095003157 malonyl-CoA binding site [chemical binding]; other site 395095003158 dimer interface [polypeptide binding]; other site 395095003159 active site 395095003160 product binding site; other site 395095003161 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 395095003162 uncharacterized domain; Region: TIGR00702 395095003163 YcaO-like family; Region: YcaO; pfam02624 395095003164 Uncharacterized conserved protein [Function unknown]; Region: COG3482 395095003165 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395095003166 S-adenosylmethionine binding site [chemical binding]; other site 395095003167 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 395095003168 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 395095003169 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 395095003170 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 395095003171 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 395095003172 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 395095003173 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 395095003174 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 395095003175 catalytic site [active] 395095003176 subunit interface [polypeptide binding]; other site 395095003177 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 395095003178 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 395095003179 S-adenosylmethionine synthetase; Validated; Region: PRK05250 395095003180 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 395095003181 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 395095003182 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 395095003183 Cytochrome P450; Region: p450; cl12078 395095003184 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 395095003185 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 395095003186 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 395095003187 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 395095003188 oligomeric interface; other site 395095003189 putative active site [active] 395095003190 homodimer interface [polypeptide binding]; other site 395095003191 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 395095003192 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 395095003193 substrate binding pocket [chemical binding]; other site 395095003194 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395095003195 S-adenosylmethionine binding site [chemical binding]; other site 395095003196 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 395095003197 MarR family; Region: MarR; pfam01047 395095003198 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395095003199 S-adenosylmethionine binding site [chemical binding]; other site 395095003200 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 395095003201 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 395095003202 putative active site [active] 395095003203 substrate binding site [chemical binding]; other site 395095003204 putative cosubstrate binding site; other site 395095003205 catalytic site [active] 395095003206 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 395095003207 substrate binding site [chemical binding]; other site 395095003208 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 395095003209 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 395095003210 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 395095003211 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 395095003212 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 395095003213 catalytic motif [active] 395095003214 Zn binding site [ion binding]; other site 395095003215 RibD C-terminal domain; Region: RibD_C; pfam01872 395095003216 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 395095003217 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 395095003218 Lumazine binding domain; Region: Lum_binding; pfam00677 395095003219 Lumazine binding domain; Region: Lum_binding; pfam00677 395095003220 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 395095003221 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 395095003222 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 395095003223 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 395095003224 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 395095003225 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 395095003226 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 395095003227 dimerization interface [polypeptide binding]; other site 395095003228 active site 395095003229 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 395095003230 homopentamer interface [polypeptide binding]; other site 395095003231 active site 395095003232 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 395095003233 PknH-like extracellular domain; Region: PknH_C; pfam14032 395095003234 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 395095003235 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 395095003236 putative sugar binding sites [chemical binding]; other site 395095003237 Q-X-W motif; other site 395095003238 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 395095003239 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 395095003240 GIY-YIG motif/motif A; other site 395095003241 active site 395095003242 catalytic site [active] 395095003243 putative DNA binding site [nucleotide binding]; other site 395095003244 metal binding site [ion binding]; metal-binding site 395095003245 UvrB/uvrC motif; Region: UVR; pfam02151 395095003246 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 395095003247 Helix-hairpin-helix motif; Region: HHH; pfam00633 395095003248 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 395095003249 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 395095003250 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 395095003251 phosphate binding site [ion binding]; other site 395095003252 putative substrate binding pocket [chemical binding]; other site 395095003253 dimer interface [polypeptide binding]; other site 395095003254 acyl-CoA synthetase; Provisional; Region: PRK13382 395095003255 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 395095003256 acyl-activating enzyme (AAE) consensus motif; other site 395095003257 putative AMP binding site [chemical binding]; other site 395095003258 putative active site [active] 395095003259 putative CoA binding site [chemical binding]; other site 395095003260 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 395095003261 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 395095003262 putative acyl-acceptor binding pocket; other site 395095003263 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 395095003264 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 395095003265 PE family; Region: PE; pfam00934 395095003266 PE-PPE domain; Region: PE-PPE; pfam08237 395095003267 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 395095003268 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 395095003269 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 395095003270 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 395095003271 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 395095003272 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 395095003273 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 395095003274 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 395095003275 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 395095003276 Phosphoglycerate kinase; Region: PGK; pfam00162 395095003277 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 395095003278 substrate binding site [chemical binding]; other site 395095003279 hinge regions; other site 395095003280 ADP binding site [chemical binding]; other site 395095003281 catalytic site [active] 395095003282 triosephosphate isomerase; Provisional; Region: PRK14567 395095003283 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 395095003284 substrate binding site [chemical binding]; other site 395095003285 dimer interface [polypeptide binding]; other site 395095003286 catalytic triad [active] 395095003287 SnoaL-like domain; Region: SnoaL_2; pfam12680 395095003288 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 395095003289 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 395095003290 molybdopterin cofactor binding site [chemical binding]; other site 395095003291 substrate binding site [chemical binding]; other site 395095003292 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 395095003293 molybdopterin cofactor binding site; other site 395095003294 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 395095003295 hydrophobic ligand binding site; other site 395095003296 Proteins of 100 residues with WXG; Region: WXG100; cl02005 395095003297 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 395095003298 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 395095003299 putative active site [active] 395095003300 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 395095003301 Glucose-6-P dehydrogenase subunit [Carbohydrate transport and metabolism]; Region: COG3429 395095003302 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 395095003303 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 395095003304 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 395095003305 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 395095003306 putative active site [active] 395095003307 transaldolase; Provisional; Region: PRK03903 395095003308 catalytic residue [active] 395095003309 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 395095003310 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 395095003311 TPP-binding site [chemical binding]; other site 395095003312 dimer interface [polypeptide binding]; other site 395095003313 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 395095003314 PYR/PP interface [polypeptide binding]; other site 395095003315 dimer interface [polypeptide binding]; other site 395095003316 TPP binding site [chemical binding]; other site 395095003317 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 395095003318 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 395095003319 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 395095003320 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 395095003321 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 395095003322 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 395095003323 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 395095003324 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 395095003325 Walker A/P-loop; other site 395095003326 ATP binding site [chemical binding]; other site 395095003327 Q-loop/lid; other site 395095003328 ABC transporter signature motif; other site 395095003329 Walker B; other site 395095003330 D-loop; other site 395095003331 H-loop/switch region; other site 395095003332 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 395095003333 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 395095003334 protein-splicing catalytic site; other site 395095003335 thioester formation/cholesterol transfer; other site 395095003336 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 395095003337 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 395095003338 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 395095003339 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 395095003340 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 395095003341 Walker A/P-loop; other site 395095003342 ATP binding site [chemical binding]; other site 395095003343 Q-loop/lid; other site 395095003344 ABC transporter signature motif; other site 395095003345 Walker B; other site 395095003346 D-loop; other site 395095003347 H-loop/switch region; other site 395095003348 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 395095003349 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 395095003350 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 395095003351 catalytic residue [active] 395095003352 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 395095003353 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 395095003354 trimerization site [polypeptide binding]; other site 395095003355 active site 395095003356 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 395095003357 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 395095003358 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 395095003359 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 395095003360 active site 395095003361 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 395095003362 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 395095003363 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 395095003364 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 395095003365 catalytic residues [active] 395095003366 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 395095003367 catalytic residues [active] 395095003368 enoyl-CoA hydratase; Provisional; Region: PRK05864 395095003369 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 395095003370 substrate binding site [chemical binding]; other site 395095003371 oxyanion hole (OAH) forming residues; other site 395095003372 trimer interface [polypeptide binding]; other site 395095003373 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 395095003374 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 395095003375 Walker A/P-loop; other site 395095003376 ATP binding site [chemical binding]; other site 395095003377 Q-loop/lid; other site 395095003378 ABC transporter signature motif; other site 395095003379 Walker B; other site 395095003380 D-loop; other site 395095003381 H-loop/switch region; other site 395095003382 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 395095003383 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 395095003384 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 395095003385 aconitate hydratase; Validated; Region: PRK09277 395095003386 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 395095003387 substrate binding site [chemical binding]; other site 395095003388 ligand binding site [chemical binding]; other site 395095003389 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 395095003390 substrate binding site [chemical binding]; other site 395095003391 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 395095003392 NlpC/P60 family; Region: NLPC_P60; pfam00877 395095003393 MoxR-like ATPases [General function prediction only]; Region: COG0714 395095003394 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395095003395 Walker A motif; other site 395095003396 ATP binding site [chemical binding]; other site 395095003397 Walker B motif; other site 395095003398 arginine finger; other site 395095003399 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 395095003400 Protein of unknown function DUF58; Region: DUF58; pfam01882 395095003401 hypothetical protein; Provisional; Region: PRK13685 395095003402 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 395095003403 metal ion-dependent adhesion site (MIDAS); other site 395095003404 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 395095003405 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 395095003406 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 395095003407 NAD(P) binding site [chemical binding]; other site 395095003408 homotetramer interface [polypeptide binding]; other site 395095003409 homodimer interface [polypeptide binding]; other site 395095003410 active site 395095003411 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 395095003412 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 395095003413 NAD binding site [chemical binding]; other site 395095003414 homotetramer interface [polypeptide binding]; other site 395095003415 homodimer interface [polypeptide binding]; other site 395095003416 substrate binding site [chemical binding]; other site 395095003417 active site 395095003418 ferrochelatase; Reviewed; Region: hemH; PRK00035 395095003419 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 395095003420 C-terminal domain interface [polypeptide binding]; other site 395095003421 active site 395095003422 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 395095003423 active site 395095003424 N-terminal domain interface [polypeptide binding]; other site 395095003425 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 395095003426 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 395095003427 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 395095003428 Uncharacterized conserved protein [Function unknown]; Region: COG0398 395095003429 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 395095003430 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 395095003431 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 395095003432 active site 395095003433 substrate binding site [chemical binding]; other site 395095003434 coenzyme B12 binding site [chemical binding]; other site 395095003435 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 395095003436 B12 binding site [chemical binding]; other site 395095003437 cobalt ligand [ion binding]; other site 395095003438 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 395095003439 membrane ATPase/protein kinase; Provisional; Region: PRK09435 395095003440 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 395095003441 Walker A; other site 395095003442 Uncharacterized conserved protein [Function unknown]; Region: COG3360 395095003443 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 395095003444 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 395095003445 Ligand binding site; other site 395095003446 Putative Catalytic site; other site 395095003447 DXD motif; other site 395095003448 Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5285 395095003449 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 395095003450 active site 395095003451 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 395095003452 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 395095003453 inhibitor-cofactor binding pocket; inhibition site 395095003454 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395095003455 catalytic residue [active] 395095003456 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 395095003457 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 395095003458 putative trimer interface [polypeptide binding]; other site 395095003459 putative CoA binding site [chemical binding]; other site 395095003460 WbqC-like protein family; Region: WbqC; pfam08889 395095003461 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 395095003462 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395095003463 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395095003464 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 395095003465 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 395095003466 NADP-binding site; other site 395095003467 homotetramer interface [polypeptide binding]; other site 395095003468 substrate binding site [chemical binding]; other site 395095003469 homodimer interface [polypeptide binding]; other site 395095003470 active site 395095003471 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 395095003472 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 395095003473 metal-binding site 395095003474 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395095003475 S-adenosylmethionine binding site [chemical binding]; other site 395095003476 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 395095003477 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 395095003478 active site 395095003479 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 395095003480 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 395095003481 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 395095003482 active site 395095003483 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 395095003484 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 395095003485 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 395095003486 active site 395095003487 acyl-CoA synthetase; Validated; Region: PRK05850 395095003488 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 395095003489 acyl-activating enzyme (AAE) consensus motif; other site 395095003490 active site 395095003491 Methyltransferase domain; Region: Methyltransf_23; pfam13489 395095003492 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395095003493 S-adenosylmethionine binding site [chemical binding]; other site 395095003494 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 395095003495 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 395095003496 homodimer interface [polypeptide binding]; other site 395095003497 active site 395095003498 TDP-binding site; other site 395095003499 acceptor substrate-binding pocket; other site 395095003500 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 395095003501 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 395095003502 Probable Catalytic site; other site 395095003503 metal-binding site 395095003504 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 395095003505 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 395095003506 homodimer interface [polypeptide binding]; other site 395095003507 active site 395095003508 TDP-binding site; other site 395095003509 acceptor substrate-binding pocket; other site 395095003510 acyl-CoA synthetase; Validated; Region: PRK05850 395095003511 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 395095003512 acyl-activating enzyme (AAE) consensus motif; other site 395095003513 active site 395095003514 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 395095003515 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 395095003516 NAD(P) binding site [chemical binding]; other site 395095003517 Uncharacterized conserved protein [Function unknown]; Region: COG2128 395095003518 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 395095003519 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 395095003520 CoenzymeA binding site [chemical binding]; other site 395095003521 subunit interaction site [polypeptide binding]; other site 395095003522 PHB binding site; other site 395095003523 Nitronate monooxygenase; Region: NMO; pfam03060 395095003524 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 395095003525 FMN binding site [chemical binding]; other site 395095003526 substrate binding site [chemical binding]; other site 395095003527 putative catalytic residue [active] 395095003528 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 395095003529 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 395095003530 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 395095003531 HIGH motif; other site 395095003532 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 395095003533 active site 395095003534 KMSKS motif; other site 395095003535 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 395095003536 tRNA binding surface [nucleotide binding]; other site 395095003537 anticodon binding site; other site 395095003538 DNA polymerase IV; Provisional; Region: PRK03348 395095003539 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 395095003540 active site 395095003541 DNA binding site [nucleotide binding] 395095003542 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 395095003543 active site 395095003544 homodimer interface [polypeptide binding]; other site 395095003545 homotetramer interface [polypeptide binding]; other site 395095003546 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 395095003547 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 395095003548 active site 395095003549 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 395095003550 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 395095003551 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 395095003552 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 395095003553 apolar tunnel; other site 395095003554 heme binding site [chemical binding]; other site 395095003555 dimerization interface [polypeptide binding]; other site 395095003556 short chain dehydrogenase; Provisional; Region: PRK05866 395095003557 classical (c) SDRs; Region: SDR_c; cd05233 395095003558 NAD(P) binding site [chemical binding]; other site 395095003559 active site 395095003560 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 395095003561 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395095003562 NAD(P) binding site [chemical binding]; other site 395095003563 active site 395095003564 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 395095003565 hydrophobic ligand binding site; other site 395095003566 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 395095003567 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 395095003568 active site 395095003569 PHP Thumb interface [polypeptide binding]; other site 395095003570 metal binding site [ion binding]; metal-binding site 395095003571 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 395095003572 generic binding surface II; other site 395095003573 generic binding surface I; other site 395095003574 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 395095003575 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 395095003576 acyl-activating enzyme (AAE) consensus motif; other site 395095003577 putative AMP binding site [chemical binding]; other site 395095003578 putative active site [active] 395095003579 putative CoA binding site [chemical binding]; other site 395095003580 glycerol-3-phosphate acyltransferase; Reviewed; Region: PRK11915 395095003581 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 395095003582 putative acyl-acceptor binding pocket; other site 395095003583 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 395095003584 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 395095003585 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 395095003586 D-subunit interface [polypeptide binding]; other site 395095003587 Iron-sulfur protein interface; other site 395095003588 proximal quinone binding site [chemical binding]; other site 395095003589 distal quinone binding site [chemical binding]; other site 395095003590 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 395095003591 Iron-sulfur protein interface; other site 395095003592 proximal quinone binding site [chemical binding]; other site 395095003593 C-subunit interface; other site 395095003594 distal quinone binding site; other site 395095003595 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 395095003596 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 395095003597 Domain of unknown function (DUF385); Region: DUF385; pfam04075 395095003598 threonine dehydratase; Validated; Region: PRK08639 395095003599 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 395095003600 tetramer interface [polypeptide binding]; other site 395095003601 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395095003602 catalytic residue [active] 395095003603 C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585 395095003604 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 395095003605 putative active site [active] 395095003606 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 395095003607 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 395095003608 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 395095003609 catalytic site [active] 395095003610 active site 395095003611 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 395095003612 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 395095003613 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 395095003614 active site 395095003615 catalytic site [active] 395095003616 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 395095003617 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 395095003618 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 395095003619 active site 395095003620 catalytic site [active] 395095003621 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 395095003622 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 395095003623 NlpC/P60 family; Region: NLPC_P60; pfam00877 395095003624 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 395095003625 Protein of unknown function (DUF2567); Region: DUF2567; pfam10821 395095003626 Secretory lipase; Region: LIP; pfam03583 395095003627 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 395095003628 nudix motif; other site 395095003629 quinolinate synthetase; Provisional; Region: PRK09375 395095003630 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 395095003631 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 395095003632 dimerization interface [polypeptide binding]; other site 395095003633 active site 395095003634 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395095003635 S-adenosylmethionine binding site [chemical binding]; other site 395095003636 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 395095003637 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 395095003638 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 395095003639 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395095003640 homodimer interface [polypeptide binding]; other site 395095003641 catalytic residue [active] 395095003642 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 395095003643 4-fold oligomerization interface [polypeptide binding]; other site 395095003644 putative active site pocket [active] 395095003645 metal binding residues [ion binding]; metal-binding site 395095003646 3-fold/trimer interface [polypeptide binding]; other site 395095003647 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 395095003648 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 395095003649 putative active site [active] 395095003650 oxyanion strand; other site 395095003651 catalytic triad [active] 395095003652 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 395095003653 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 395095003654 catalytic residues [active] 395095003655 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 395095003656 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 395095003657 active site 395095003658 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 395095003659 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 395095003660 substrate binding site [chemical binding]; other site 395095003661 glutamase interaction surface [polypeptide binding]; other site 395095003662 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 395095003663 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 395095003664 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 395095003665 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 395095003666 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 395095003667 catalytic triad [active] 395095003668 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 395095003669 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 395095003670 active site 395095003671 ribulose/triose binding site [chemical binding]; other site 395095003672 phosphate binding site [ion binding]; other site 395095003673 substrate (anthranilate) binding pocket [chemical binding]; other site 395095003674 product (indole) binding pocket [chemical binding]; other site 395095003675 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 395095003676 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 395095003677 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395095003678 catalytic residue [active] 395095003679 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108 395095003680 Prolipoprotein diacylglyceryltransferase [Cell envelope biogenesis, outer membrane]; Region: Lgt; COG0682 395095003681 TM2 domain; Region: TM2; pfam05154 395095003682 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 395095003683 pyruvate kinase; Provisional; Region: PRK06247 395095003684 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 395095003685 domain interfaces; other site 395095003686 active site 395095003687 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 395095003688 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 395095003689 active site 395095003690 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 395095003691 catalytic triad [active] 395095003692 dimer interface [polypeptide binding]; other site 395095003693 Uncharacterized conserved protein [Function unknown]; Region: COG2898 395095003694 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 395095003695 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 395095003696 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 395095003697 Walker A/P-loop; other site 395095003698 ATP binding site [chemical binding]; other site 395095003699 Q-loop/lid; other site 395095003700 ABC transporter signature motif; other site 395095003701 Walker B; other site 395095003702 D-loop; other site 395095003703 H-loop/switch region; other site 395095003704 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 395095003705 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 395095003706 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 395095003707 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 395095003708 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 395095003709 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 395095003710 cyclase homology domain; Region: CHD; cd07302 395095003711 nucleotidyl binding site; other site 395095003712 metal binding site [ion binding]; metal-binding site 395095003713 dimer interface [polypeptide binding]; other site 395095003714 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 395095003715 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395095003716 active site 395095003717 phosphorylation site [posttranslational modification] 395095003718 intermolecular recognition site; other site 395095003719 dimerization interface [polypeptide binding]; other site 395095003720 ANTAR domain; Region: ANTAR; pfam03861 395095003721 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 395095003722 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 395095003723 DUF35 OB-fold domain; Region: DUF35; pfam01796 395095003724 DNA polymerase I; Provisional; Region: PRK05755 395095003725 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 395095003726 active site 395095003727 metal binding site 1 [ion binding]; metal-binding site 395095003728 putative 5' ssDNA interaction site; other site 395095003729 metal binding site 3; metal-binding site 395095003730 metal binding site 2 [ion binding]; metal-binding site 395095003731 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 395095003732 putative DNA binding site [nucleotide binding]; other site 395095003733 putative metal binding site [ion binding]; other site 395095003734 3'-5' exonuclease; Region: 35EXOc; smart00474 395095003735 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 395095003736 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 395095003737 active site 395095003738 DNA binding site [nucleotide binding] 395095003739 catalytic site [active] 395095003740 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 395095003741 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 395095003742 RNA binding site [nucleotide binding]; other site 395095003743 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 395095003744 RNA binding site [nucleotide binding]; other site 395095003745 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 395095003746 RNA binding site [nucleotide binding]; other site 395095003747 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 395095003748 RNA binding site [nucleotide binding]; other site 395095003749 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 395095003750 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 395095003751 CoA-binding site [chemical binding]; other site 395095003752 ATP-binding [chemical binding]; other site 395095003753 Uncharacterized conserved protein [Function unknown]; Region: GrpB; COG2320 395095003754 Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306 395095003755 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 395095003756 Major Facilitator Superfamily; Region: MFS_1; pfam07690 395095003757 putative substrate translocation pore; other site 395095003758 Predicted membrane protein [Function unknown]; Region: COG5305 395095003759 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 395095003760 Ligand Binding Site [chemical binding]; other site 395095003761 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 395095003762 Predicted esterase [General function prediction only]; Region: COG0627 395095003763 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 395095003764 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 395095003765 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 395095003766 dimer interface [polypeptide binding]; other site 395095003767 putative anticodon binding site; other site 395095003768 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 395095003769 motif 1; other site 395095003770 dimer interface [polypeptide binding]; other site 395095003771 active site 395095003772 motif 2; other site 395095003773 motif 3; other site 395095003774 translation initiation factor IF-3; Region: infC; TIGR00168 395095003775 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 395095003776 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 395095003777 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 395095003778 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 395095003779 23S rRNA binding site [nucleotide binding]; other site 395095003780 L21 binding site [polypeptide binding]; other site 395095003781 L13 binding site [polypeptide binding]; other site 395095003782 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 395095003783 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 395095003784 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 395095003785 PE family; Region: PE; pfam00934 395095003786 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 395095003787 cyclase homology domain; Region: CHD; cd07302 395095003788 nucleotidyl binding site; other site 395095003789 metal binding site [ion binding]; metal-binding site 395095003790 dimer interface [polypeptide binding]; other site 395095003791 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 395095003792 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 395095003793 putative tRNA-binding site [nucleotide binding]; other site 395095003794 B3/4 domain; Region: B3_4; pfam03483 395095003795 tRNA synthetase B5 domain; Region: B5; smart00874 395095003796 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 395095003797 dimer interface [polypeptide binding]; other site 395095003798 motif 1; other site 395095003799 motif 3; other site 395095003800 motif 2; other site 395095003801 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 395095003802 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 395095003803 feedback inhibition sensing region; other site 395095003804 homohexameric interface [polypeptide binding]; other site 395095003805 nucleotide binding site [chemical binding]; other site 395095003806 N-acetyl-L-glutamate binding site [chemical binding]; other site 395095003807 ornithine carbamoyltransferase; Provisional; Region: PRK00779 395095003808 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 395095003809 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 395095003810 argininosuccinate lyase; Provisional; Region: PRK00855 395095003811 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 395095003812 active sites [active] 395095003813 tetramer interface [polypeptide binding]; other site 395095003814 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 395095003815 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 395095003816 malonyl-CoA binding site [chemical binding]; other site 395095003817 dimer interface [polypeptide binding]; other site 395095003818 active site 395095003819 product binding site; other site 395095003820 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 395095003821 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 395095003822 active site 395095003823 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 395095003824 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 395095003825 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395095003826 Enoylreductase; Region: PKS_ER; smart00829 395095003827 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 395095003828 NAD(P) binding site [chemical binding]; other site 395095003829 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 395095003830 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 395095003831 putative NADP binding site [chemical binding]; other site 395095003832 active site 395095003833 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 395095003834 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 395095003835 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 395095003836 active site 395095003837 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 395095003838 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 395095003839 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395095003840 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 395095003841 Enoylreductase; Region: PKS_ER; smart00829 395095003842 NAD(P) binding site [chemical binding]; other site 395095003843 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 395095003844 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 395095003845 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 395095003846 putative NADP binding site [chemical binding]; other site 395095003847 active site 395095003848 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 395095003849 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 395095003850 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 395095003851 active site 395095003852 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 395095003853 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 395095003854 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 395095003855 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 395095003856 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 395095003857 malonyl-CoA binding site [chemical binding]; other site 395095003858 dimer interface [polypeptide binding]; other site 395095003859 active site 395095003860 product binding site; other site 395095003861 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 395095003862 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 395095003863 ABC transporter; Region: ABC_tran_2; pfam12848 395095003864 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 395095003865 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 395095003866 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 395095003867 putative substrate translocation pore; other site 395095003868 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 395095003869 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 395095003870 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 395095003871 dimerization interface [polypeptide binding]; other site 395095003872 putative DNA binding site [nucleotide binding]; other site 395095003873 putative Zn2+ binding site [ion binding]; other site 395095003874 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 395095003875 active site residue [active] 395095003876 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 395095003877 putative catalytic residues [active] 395095003878 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 395095003879 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 395095003880 catalytic residues [active] 395095003881 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 395095003882 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 395095003883 active site 395095003884 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 395095003885 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 395095003886 substrate binding pocket [chemical binding]; other site 395095003887 membrane-bound complex binding site; other site 395095003888 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 395095003889 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 395095003890 FeS/SAM binding site; other site 395095003891 DivIVA protein; Region: DivIVA; pfam05103 395095003892 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 395095003893 acyl-CoA synthetase; Validated; Region: PRK07868 395095003894 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 395095003895 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 395095003896 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 395095003897 acyl-activating enzyme (AAE) consensus motif; other site 395095003898 AMP binding site [chemical binding]; other site 395095003899 active site 395095003900 CoA binding site [chemical binding]; other site 395095003901 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 395095003902 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 395095003903 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 395095003904 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 395095003905 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 395095003906 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 395095003907 Walker A/P-loop; other site 395095003908 ATP binding site [chemical binding]; other site 395095003909 Q-loop/lid; other site 395095003910 ABC transporter signature motif; other site 395095003911 Walker B; other site 395095003912 D-loop; other site 395095003913 H-loop/switch region; other site 395095003914 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 395095003915 active site 395095003916 DNA binding site [nucleotide binding] 395095003917 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 395095003918 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 395095003919 active site 395095003920 HIGH motif; other site 395095003921 dimer interface [polypeptide binding]; other site 395095003922 KMSKS motif; other site 395095003923 S4 RNA-binding domain; Region: S4; smart00363 395095003924 RNA binding surface [nucleotide binding]; other site 395095003925 Protein of unknown function (DUF732); Region: DUF732; pfam05305 395095003926 Tetratrico peptide repeat; Region: TPR_5; pfam12688 395095003927 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 395095003928 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 395095003929 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 395095003930 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 395095003931 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 395095003932 RNA binding surface [nucleotide binding]; other site 395095003933 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395095003934 S-adenosylmethionine binding site [chemical binding]; other site 395095003935 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 395095003936 ATP-NAD kinase; Region: NAD_kinase; pfam01513 395095003937 DNA repair protein RecN; Region: recN; TIGR00634 395095003938 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 395095003939 Walker A/P-loop; other site 395095003940 ATP binding site [chemical binding]; other site 395095003941 Q-loop/lid; other site 395095003942 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 395095003943 ABC transporter signature motif; other site 395095003944 Walker B; other site 395095003945 D-loop; other site 395095003946 H-loop/switch region; other site 395095003947 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 395095003948 Thiamine pyrophosphokinase; Region: TPK; cl08415 395095003949 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 395095003950 CTP synthetase; Validated; Region: pyrG; PRK05380 395095003951 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 395095003952 Catalytic site [active] 395095003953 active site 395095003954 UTP binding site [chemical binding]; other site 395095003955 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 395095003956 active site 395095003957 putative oxyanion hole; other site 395095003958 catalytic triad [active] 395095003959 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 395095003960 dimer interface [polypeptide binding]; other site 395095003961 ADP-ribose binding site [chemical binding]; other site 395095003962 active site 395095003963 nudix motif; other site 395095003964 metal binding site [ion binding]; metal-binding site 395095003965 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 395095003966 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 395095003967 active site 395095003968 DNA binding site [nucleotide binding] 395095003969 Int/Topo IB signature motif; other site 395095003970 Domain of unknown function (DUF222); Region: DUF222; pfam02720 395095003971 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 395095003972 active site 395095003973 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 395095003974 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395095003975 S-adenosylmethionine binding site [chemical binding]; other site 395095003976 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 395095003977 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 395095003978 PPE family; Region: PPE; pfam00823 395095003979 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 395095003980 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 395095003981 PPE family; Region: PPE; pfam00823 395095003982 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 395095003983 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 395095003984 Sulfate transporter family; Region: Sulfate_transp; pfam00916 395095003985 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 395095003986 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 395095003987 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 395095003988 P-loop; other site 395095003989 Magnesium ion binding site [ion binding]; other site 395095003990 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 395095003991 Magnesium ion binding site [ion binding]; other site 395095003992 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 395095003993 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 395095003994 cytidylate kinase; Provisional; Region: cmk; PRK00023 395095003995 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 395095003996 CMP-binding site; other site 395095003997 The sites determining sugar specificity; other site 395095003998 GTP-binding protein Der; Reviewed; Region: PRK03003 395095003999 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 395095004000 GTP/Mg2+ binding site [chemical binding]; other site 395095004001 Switch I region; other site 395095004002 G2 box; other site 395095004003 Switch II region; other site 395095004004 G3 box; other site 395095004005 G4 box; other site 395095004006 G5 box; other site 395095004007 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 395095004008 G1 box; other site 395095004009 GTP/Mg2+ binding site [chemical binding]; other site 395095004010 Switch I region; other site 395095004011 G2 box; other site 395095004012 G3 box; other site 395095004013 Switch II region; other site 395095004014 G4 box; other site 395095004015 G5 box; other site 395095004016 short chain dehydrogenase; Provisional; Region: PRK07060 395095004017 classical (c) SDRs; Region: SDR_c; cd05233 395095004018 NAD(P) binding site [chemical binding]; other site 395095004019 active site 395095004020 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 395095004021 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 395095004022 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 395095004023 Cupin domain; Region: Cupin_2; pfam07883 395095004024 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 395095004025 Transcriptional regulator [Transcription]; Region: IclR; COG1414 395095004026 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 395095004027 putative switch regulator; other site 395095004028 non-specific DNA interactions [nucleotide binding]; other site 395095004029 DNA binding site [nucleotide binding] 395095004030 sequence specific DNA binding site [nucleotide binding]; other site 395095004031 putative cAMP binding site [chemical binding]; other site 395095004032 Bacterial transcriptional regulator; Region: IclR; pfam01614 395095004033 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 395095004034 putative active site [active] 395095004035 homotetrameric interface [polypeptide binding]; other site 395095004036 metal binding site [ion binding]; metal-binding site 395095004037 biotin carboxylase-like protein; Validated; Region: PRK06524 395095004038 ATP-grasp domain; Region: ATP-grasp_4; cl17255 395095004039 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 395095004040 Beta-lactamase; Region: Beta-lactamase; pfam00144 395095004041 Predicted transcriptional regulators [Transcription]; Region: COG1733 395095004042 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 395095004043 dimerization interface [polypeptide binding]; other site 395095004044 putative DNA binding site [nucleotide binding]; other site 395095004045 putative Zn2+ binding site [ion binding]; other site 395095004046 Predicted transcriptional regulators [Transcription]; Region: COG1733 395095004047 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 395095004048 FAD binding domain; Region: FAD_binding_4; pfam01565 395095004049 Berberine and berberine like; Region: BBE; pfam08031 395095004050 TIGR03086 family protein; Region: TIGR03086 395095004051 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 395095004052 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 395095004053 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 395095004054 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 395095004055 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 395095004056 NAD(P) binding site [chemical binding]; other site 395095004057 catalytic residues [active] 395095004058 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 395095004059 putative catalytic residue [active] 395095004060 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 395095004061 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 395095004062 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 395095004063 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 395095004064 gating phenylalanine in ion channel; other site 395095004065 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 395095004066 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 395095004067 Sulfate transporter family; Region: Sulfate_transp; pfam00916 395095004068 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 395095004069 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 395095004070 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3742 395095004071 putative active site [active] 395095004072 Protein tyrosine kinase; Region: Pkinase_Tyr; pfam07714 395095004073 Catalytic domain of Protein Kinases; Region: PKc; cd00180 395095004074 active site 395095004075 ATP binding site [chemical binding]; other site 395095004076 substrate binding site [chemical binding]; other site 395095004077 activation loop (A-loop); other site 395095004078 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 395095004079 Thioredoxin; Region: Thioredoxin_4; cl17273 395095004080 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 395095004081 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 395095004082 active site 395095004083 metal binding site [ion binding]; metal-binding site 395095004084 nudix motif; other site 395095004085 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 395095004086 Catalytic domain of Protein Kinases; Region: PKc; cd00180 395095004087 active site 395095004088 ATP binding site [chemical binding]; other site 395095004089 substrate binding site [chemical binding]; other site 395095004090 activation loop (A-loop); other site 395095004091 acyl-CoA synthetase; Provisional; Region: PRK13388 395095004092 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 395095004093 acyl-activating enzyme (AAE) consensus motif; other site 395095004094 AMP binding site [chemical binding]; other site 395095004095 active site 395095004096 CoA binding site [chemical binding]; other site 395095004097 hypothetical protein; Provisional; Region: PRK06185 395095004098 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 395095004099 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 395095004100 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 395095004101 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 395095004102 PPE family; Region: PPE; pfam00823 395095004103 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 395095004104 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 395095004105 putative transposase OrfB; Reviewed; Region: PHA02517 395095004106 HTH-like domain; Region: HTH_21; pfam13276 395095004107 Integrase core domain; Region: rve; pfam00665 395095004108 Integrase core domain; Region: rve_3; pfam13683 395095004109 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 395095004110 Phosphoesterase family; Region: Phosphoesterase; pfam04185 395095004111 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 395095004112 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 395095004113 Transport protein; Region: actII; TIGR00833 395095004114 Uncharacterized conserved protein [Function unknown]; Region: COG0393 395095004115 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 395095004116 Integrase core domain; Region: rve; pfam00665 395095004117 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 395095004118 putative homotetramer interface [polypeptide binding]; other site 395095004119 putative homodimer interface [polypeptide binding]; other site 395095004120 putative allosteric switch controlling residues; other site 395095004121 putative metal binding site [ion binding]; other site 395095004122 putative homodimer-homodimer interface [polypeptide binding]; other site 395095004123 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 395095004124 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 395095004125 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 395095004126 metal binding site [ion binding]; metal-binding site 395095004127 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 395095004128 FAD binding domain; Region: FAD_binding_4; pfam01565 395095004129 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 395095004130 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 395095004131 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 395095004132 Transcriptional regulator [Transcription]; Region: IclR; COG1414 395095004133 Bacterial transcriptional regulator; Region: IclR; pfam01614 395095004134 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 395095004135 FAD binding domain; Region: FAD_binding_4; pfam01565 395095004136 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 395095004137 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 395095004138 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 395095004139 Cytochrome P450; Region: p450; cl12078 395095004140 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 395095004141 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 395095004142 Protein of unknown function (DUF690); Region: DUF690; pfam05108 395095004143 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 395095004144 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 395095004145 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 395095004146 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 395095004147 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 395095004148 Cytochrome P450; Region: p450; cl12078 395095004149 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 395095004150 PE family; Region: PE; pfam00934 395095004151 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 395095004152 PPE family; Region: PPE; pfam00823 395095004153 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 395095004154 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 395095004155 PPE family; Region: PPE; pfam00823 395095004156 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 395095004157 PE family; Region: PE; pfam00934 395095004158 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 395095004159 EspG family; Region: ESX-1_EspG; pfam14011 395095004160 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 395095004161 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 395095004162 catalytic residues [active] 395095004163 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 395095004164 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 395095004165 active site 395095004166 catalytic residues [active] 395095004167 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 395095004168 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 395095004169 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395095004170 Walker A motif; other site 395095004171 ATP binding site [chemical binding]; other site 395095004172 Walker B motif; other site 395095004173 arginine finger; other site 395095004174 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 395095004175 PPE family; Region: PPE; pfam00823 395095004176 PE-PPE domain; Region: PE-PPE; pfam08237 395095004177 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 395095004178 PPE family; Region: PPE; pfam00823 395095004179 PE family; Region: PE; pfam00934 395095004180 Protein of unknown function (DUF732); Region: DUF732; pfam05305 395095004181 PE family; Region: PE; pfam00934 395095004182 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 395095004183 PPE family; Region: PPE; pfam00823 395095004184 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 395095004185 PPE family; Region: PPE; pfam00823 395095004186 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 395095004187 Protein of unknown function (DUF732); Region: DUF732; pfam05305 395095004188 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 395095004189 MgtC family; Region: MgtC; pfam02308 395095004190 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 395095004191 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 395095004192 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 395095004193 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 395095004194 hypothetical protein; Validated; Region: PRK07121 395095004195 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 395095004196 ABC transporter transmembrane region 2; Region: ABC_membrane_2; pfam06472 395095004197 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 395095004198 hypothetical protein; Provisional; Region: PRK05858 395095004199 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 395095004200 PYR/PP interface [polypeptide binding]; other site 395095004201 dimer interface [polypeptide binding]; other site 395095004202 TPP binding site [chemical binding]; other site 395095004203 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 395095004204 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 395095004205 TPP-binding site; other site 395095004206 dimer interface [polypeptide binding]; other site 395095004207 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 395095004208 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 395095004209 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 395095004210 nucleotide binding region [chemical binding]; other site 395095004211 ATP-binding site [chemical binding]; other site 395095004212 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 395095004213 Uncharacterized conserved protein (small basic protein) [Function unknown]; Region: Sbp; COG3856 395095004214 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 395095004215 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 395095004216 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 395095004217 lipoyl attachment site [posttranslational modification]; other site 395095004218 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 395095004219 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 395095004220 phosphopeptide binding site; other site 395095004221 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 395095004222 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 395095004223 DNA binding residues [nucleotide binding] 395095004224 Bifunctional nuclease; Region: DNase-RNase; pfam02577 395095004225 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 395095004226 DNA binding residues [nucleotide binding] 395095004227 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 395095004228 putative dimer interface [polypeptide binding]; other site 395095004229 glycine dehydrogenase; Provisional; Region: PRK05367 395095004230 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 395095004231 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395095004232 tetramer interface [polypeptide binding]; other site 395095004233 catalytic residue [active] 395095004234 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 395095004235 tetramer interface [polypeptide binding]; other site 395095004236 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395095004237 catalytic residue [active] 395095004238 haloalkane dehalogenase; Provisional; Region: PRK03204 395095004239 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 395095004240 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 395095004241 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 395095004242 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 395095004243 putative active site [active] 395095004244 Domain of unknown function DUF21; Region: DUF21; pfam01595 395095004245 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 395095004246 FOG: CBS domain [General function prediction only]; Region: COG0517 395095004247 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 395095004248 Domain of unknown function DUF21; Region: DUF21; pfam01595 395095004249 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 395095004250 Transporter associated domain; Region: CorC_HlyC; smart01091 395095004251 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 395095004252 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 395095004253 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 395095004254 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 395095004255 Predicted transcriptional regulator [Transcription]; Region: COG3682 395095004256 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 395095004257 CoenzymeA binding site [chemical binding]; other site 395095004258 subunit interaction site [polypeptide binding]; other site 395095004259 PHB binding site; other site 395095004260 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 395095004261 alpha-gamma subunit interface [polypeptide binding]; other site 395095004262 beta-gamma subunit interface [polypeptide binding]; other site 395095004263 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 395095004264 gamma-beta subunit interface [polypeptide binding]; other site 395095004265 alpha-beta subunit interface [polypeptide binding]; other site 395095004266 urease subunit alpha; Reviewed; Region: ureC; PRK13206 395095004267 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 395095004268 subunit interactions [polypeptide binding]; other site 395095004269 active site 395095004270 flap region; other site 395095004271 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 395095004272 UreD urease accessory protein; Region: UreD; cl00530 395095004273 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 395095004274 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 395095004275 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 395095004276 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 395095004277 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 395095004278 classical (c) SDRs; Region: SDR_c; cd05233 395095004279 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 395095004280 NAD(P) binding site [chemical binding]; other site 395095004281 active site 395095004282 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 395095004283 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 395095004284 sulfate transport protein; Provisional; Region: cysT; CHL00187 395095004285 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395095004286 dimer interface [polypeptide binding]; other site 395095004287 conserved gate region; other site 395095004288 putative PBP binding loops; other site 395095004289 ABC-ATPase subunit interface; other site 395095004290 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 395095004291 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 395095004292 Walker A/P-loop; other site 395095004293 ATP binding site [chemical binding]; other site 395095004294 Q-loop/lid; other site 395095004295 ABC transporter signature motif; other site 395095004296 Walker B; other site 395095004297 D-loop; other site 395095004298 H-loop/switch region; other site 395095004299 TOBE domain; Region: TOBE; pfam03459 395095004300 Predicted membrane protein [Function unknown]; Region: COG2261 395095004301 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 395095004302 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 395095004303 putative NAD(P) binding site [chemical binding]; other site 395095004304 putative substrate binding site [chemical binding]; other site 395095004305 catalytic Zn binding site [ion binding]; other site 395095004306 structural Zn binding site [ion binding]; other site 395095004307 CAAX protease self-immunity; Region: Abi; pfam02517 395095004308 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 395095004309 MOSC domain; Region: MOSC; pfam03473 395095004310 short chain dehydrogenase; Provisional; Region: PRK07825 395095004311 classical (c) SDRs; Region: SDR_c; cd05233 395095004312 NAD(P) binding site [chemical binding]; other site 395095004313 active site 395095004314 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 395095004315 CoA-transferase family III; Region: CoA_transf_3; pfam02515 395095004316 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 395095004317 CoA-transferase family III; Region: CoA_transf_3; pfam02515 395095004318 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 395095004319 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 395095004320 active site 395095004321 hypothetical protein; Provisional; Region: PRK12320 395095004322 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395095004323 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 395095004324 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 395095004325 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 395095004326 Domain of unknown function (DUF385); Region: DUF385; pfam04075 395095004327 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 395095004328 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 395095004329 active site 395095004330 substrate binding site [chemical binding]; other site 395095004331 FMN binding site [chemical binding]; other site 395095004332 putative catalytic residues [active] 395095004333 Uncharacterized conserved protein [Function unknown]; Region: COG5579 395095004334 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 395095004335 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 395095004336 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 395095004337 heme binding site [chemical binding]; other site 395095004338 ferroxidase pore; other site 395095004339 ferroxidase diiron center [ion binding]; other site 395095004340 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 395095004341 Major Facilitator Superfamily; Region: MFS_1; pfam07690 395095004342 putative substrate translocation pore; other site 395095004343 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 395095004344 putative substrate translocation pore; other site 395095004345 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cl00333 395095004346 23S rRNA interface [nucleotide binding]; other site 395095004347 L3 interface [polypeptide binding]; other site 395095004348 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 395095004349 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 395095004350 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 395095004351 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 395095004352 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 395095004353 Cytochrome P450; Region: p450; cl12078 395095004354 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 395095004355 short chain dehydrogenase; Provisional; Region: PRK08267 395095004356 classical (c) SDR, subgroup 9; Region: SDR_c9; cd08931 395095004357 putative NAD(P) binding site [chemical binding]; other site 395095004358 active site 395095004359 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 395095004360 hydrophobic ligand binding site; other site 395095004361 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 395095004362 chorismate mutase; Provisional; Region: PRK09269 395095004363 chorismate mutase, putative; Region: CM_mono2; TIGR01806 395095004364 Putative esterase; Region: Esterase; pfam00756 395095004365 Leucine carboxyl methyltransferase; Region: LCM; cl01306 395095004366 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 395095004367 Leucine carboxyl methyltransferase; Region: LCM; cl01306 395095004368 Uncharacterized conserved protein [Function unknown]; Region: COG2353 395095004369 Nitronate monooxygenase; Region: NMO; pfam03060 395095004370 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 395095004371 FMN binding site [chemical binding]; other site 395095004372 substrate binding site [chemical binding]; other site 395095004373 putative catalytic residue [active] 395095004374 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 2; Region: FDH_like_2; cd08284 395095004375 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 395095004376 catalytic Zn binding site [ion binding]; other site 395095004377 NAD(P) binding site [chemical binding]; other site 395095004378 structural Zn binding site [ion binding]; other site 395095004379 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 395095004380 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 395095004381 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 395095004382 putative active site [active] 395095004383 dimerization interface [polypeptide binding]; other site 395095004384 putative tRNAtyr binding site [nucleotide binding]; other site 395095004385 Domain of unknown function DUF77; Region: DUF77; pfam01910 395095004386 competence damage-inducible protein A; Provisional; Region: PRK00549 395095004387 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 395095004388 putative MPT binding site; other site 395095004389 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 395095004390 putative sialic acid transporter; Region: 2A0112; TIGR00891 395095004391 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 395095004392 putative substrate translocation pore; other site 395095004393 Predicted membrane protein [Function unknown]; Region: COG1950 395095004394 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 395095004395 anti sigma factor interaction site; other site 395095004396 regulatory phosphorylation site [posttranslational modification]; other site 395095004397 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 395095004398 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 395095004399 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 395095004400 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 395095004401 dimer interface [polypeptide binding]; other site 395095004402 active site 395095004403 heme binding site [chemical binding]; other site 395095004404 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 395095004405 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 395095004406 metal binding site 2 [ion binding]; metal-binding site 395095004407 putative DNA binding helix; other site 395095004408 metal binding site 1 [ion binding]; metal-binding site 395095004409 dimer interface [polypeptide binding]; other site 395095004410 structural Zn2+ binding site [ion binding]; other site 395095004411 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 395095004412 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR3; cd08275 395095004413 putative NAD(P) binding site [chemical binding]; other site 395095004414 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 395095004415 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 395095004416 tetramer interface [polypeptide binding]; other site 395095004417 active site 395095004418 Mg2+/Mn2+ binding site [ion binding]; other site 395095004419 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 395095004420 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 395095004421 PPE family; Region: PPE; pfam00823 395095004422 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 395095004423 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 395095004424 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 395095004425 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 395095004426 PPE family; Region: PPE; pfam00823 395095004427 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 395095004428 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 395095004429 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 395095004430 putative hydrophobic ligand binding site [chemical binding]; other site 395095004431 protein interface [polypeptide binding]; other site 395095004432 gate; other site 395095004433 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 395095004434 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 395095004435 putative acyl-acceptor binding pocket; other site 395095004436 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 395095004437 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 395095004438 Beta-lactamase; Region: Beta-lactamase; pfam00144 395095004439 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 395095004440 Beta-lactamase; Region: Beta-lactamase; pfam00144 395095004441 putative fatty-acid--CoA ligase; Provisional; Region: PRK12476 395095004442 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 395095004443 acyl-activating enzyme (AAE) consensus motif; other site 395095004444 active site 395095004445 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 395095004446 Uncharacterized conserved protein [Function unknown]; Region: COG3361 395095004447 TIGR03085 family protein; Region: TIGR03085 395095004448 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 395095004449 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 395095004450 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 395095004451 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 395095004452 dimer interface [polypeptide binding]; other site 395095004453 catalytic triad [active] 395095004454 peroxidatic and resolving cysteines [active] 395095004455 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 395095004456 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 395095004457 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 395095004458 active site 395095004459 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 395095004460 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 395095004461 FAD binding site [chemical binding]; other site 395095004462 substrate binding site [chemical binding]; other site 395095004463 catalytic base [active] 395095004464 enoyl-CoA hydratase; Provisional; Region: PRK08290 395095004465 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 395095004466 substrate binding site [chemical binding]; other site 395095004467 oxyanion hole (OAH) forming residues; other site 395095004468 trimer interface [polypeptide binding]; other site 395095004469 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 395095004470 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 395095004471 catalytic loop [active] 395095004472 iron binding site [ion binding]; other site 395095004473 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 395095004474 FAD binding pocket [chemical binding]; other site 395095004475 FAD binding motif [chemical binding]; other site 395095004476 phosphate binding motif [ion binding]; other site 395095004477 beta-alpha-beta structure motif; other site 395095004478 NAD binding pocket [chemical binding]; other site 395095004479 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 395095004480 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 395095004481 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 395095004482 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 395095004483 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 395095004484 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 395095004485 dimerization interface [polypeptide binding]; other site 395095004486 active site 395095004487 classical (c) SDR, subgroup 12; Region: SDR_c12; cd08944 395095004488 putative NAD(P) binding site [chemical binding]; other site 395095004489 active site 395095004490 homodimer interface [polypeptide binding]; other site 395095004491 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 395095004492 SEC-C motif; Region: SEC-C; pfam02810 395095004493 Domain of unknown function (DUF222); Region: DUF222; pfam02720 395095004494 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 395095004495 active site 395095004496 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487 395095004497 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 395095004498 non-specific DNA binding site [nucleotide binding]; other site 395095004499 salt bridge; other site 395095004500 sequence-specific DNA binding site [nucleotide binding]; other site 395095004501 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 395095004502 Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693 395095004503 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 395095004504 putative active site [active] 395095004505 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 395095004506 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 395095004507 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 395095004508 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 395095004509 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 395095004510 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 395095004511 Permease; Region: Permease; pfam02405 395095004512 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 395095004513 Permease; Region: Permease; pfam02405 395095004514 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 395095004515 mce related protein; Region: MCE; pfam02470 395095004516 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 395095004517 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 395095004518 mce related protein; Region: MCE; pfam02470 395095004519 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 395095004520 mce related protein; Region: MCE; pfam02470 395095004521 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 395095004522 mce related protein; Region: MCE; pfam02470 395095004523 Protein of unknown function (DUF732); Region: DUF732; pfam05305 395095004524 YacP-like NYN domain; Region: NYN_YacP; cl01491 395095004525 Peptidase family M48; Region: Peptidase_M48; pfam01435 395095004526 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395095004527 S-adenosylmethionine binding site [chemical binding]; other site 395095004528 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 395095004529 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 395095004530 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 395095004531 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 395095004532 dimer interface [polypeptide binding]; other site 395095004533 putative radical transfer pathway; other site 395095004534 diiron center [ion binding]; other site 395095004535 tyrosyl radical; other site 395095004536 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 395095004537 putative active site [active] 395095004538 PE family; Region: PE; pfam00934 395095004539 Cutinase; Region: Cutinase; pfam01083 395095004540 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 395095004541 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 395095004542 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 395095004543 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 395095004544 dimerization interface [polypeptide binding]; other site 395095004545 Lysine efflux permease [General function prediction only]; Region: COG1279 395095004546 Cellulose binding domain; Region: CBM_2; pfam00553 395095004547 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395095004548 S-adenosylmethionine binding site [chemical binding]; other site 395095004549 Uncharacterized conserved protein [Function unknown]; Region: COG5654 395095004550 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 395095004551 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 395095004552 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395095004553 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 395095004554 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 395095004555 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 395095004556 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 395095004557 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 395095004558 dimerization interface [polypeptide binding]; other site 395095004559 putative DNA binding site [nucleotide binding]; other site 395095004560 putative Zn2+ binding site [ion binding]; other site 395095004561 Hemerythrin-like domain; Region: Hr-like; cd12108 395095004562 Fe binding site [ion binding]; other site 395095004563 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 395095004564 Ligand Binding Site [chemical binding]; other site 395095004565 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 395095004566 Ligand Binding Site [chemical binding]; other site 395095004567 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 395095004568 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 395095004569 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 395095004570 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 395095004571 Soluble P-type ATPase [General function prediction only]; Region: COG4087 395095004572 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 395095004573 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 395095004574 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 395095004575 tetramer interface [polypeptide binding]; other site 395095004576 active site 395095004577 Mg2+/Mn2+ binding site [ion binding]; other site 395095004578 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 395095004579 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 395095004580 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 395095004581 3beta17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 3beta-17beta-HSD_like_SDR_c; cd05341 395095004582 homotetramer interface [polypeptide binding]; other site 395095004583 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 395095004584 NAD binding site [chemical binding]; other site 395095004585 homodimer interface [polypeptide binding]; other site 395095004586 active site 395095004587 Methyltransferase domain; Region: Methyltransf_23; pfam13489 395095004588 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395095004589 S-adenosylmethionine binding site [chemical binding]; other site 395095004590 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 395095004591 Predicted kinase [General function prediction only]; Region: COG0645 395095004592 AAA domain; Region: AAA_17; pfam13207 395095004593 Universal stress protein family; Region: Usp; pfam00582 395095004594 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 395095004595 Ligand Binding Site [chemical binding]; other site 395095004596 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 395095004597 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 395095004598 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 395095004599 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 395095004600 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 395095004601 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 395095004602 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 395095004603 Ferredoxin [Energy production and conversion]; Region: COG1146 395095004604 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 395095004605 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 395095004606 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395095004607 Walker A motif; other site 395095004608 ATP binding site [chemical binding]; other site 395095004609 Walker B motif; other site 395095004610 arginine finger; other site 395095004611 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 395095004612 putative active site [active] 395095004613 Transcriptional regulators [Transcription]; Region: MarR; COG1846 395095004614 MarR family; Region: MarR_2; pfam12802 395095004615 Phage envelope protein [General function prediction only]; Region: COG5562 395095004616 Transposase; Region: DEDD_Tnp_IS110; pfam01548 395095004617 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 395095004618 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 395095004619 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 395095004620 Domain of unknown function (DUF222); Region: DUF222; pfam02720 395095004621 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 395095004622 active site 395095004623 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 395095004624 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 395095004625 non-specific DNA binding site [nucleotide binding]; other site 395095004626 salt bridge; other site 395095004627 sequence-specific DNA binding site [nucleotide binding]; other site 395095004628 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 395095004629 Uncharacterized conserved protein [Function unknown]; Region: COG2442 395095004630 Predicted helicase [General function prediction only]; Region: COG4889 395095004631 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 395095004632 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 395095004633 non-specific DNA binding site [nucleotide binding]; other site 395095004634 salt bridge; other site 395095004635 sequence-specific DNA binding site [nucleotide binding]; other site 395095004636 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4683 395095004637 Predicted helicase [General function prediction only]; Region: COG4889 395095004638 Restriction endonuclease; Region: Mrr_cat_2; pfam13156 395095004639 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 395095004640 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 395095004641 ATP binding site [chemical binding]; other site 395095004642 putative Mg++ binding site [ion binding]; other site 395095004643 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 395095004644 ATP-binding site [chemical binding]; other site 395095004645 Methyltransferase domain; Region: Methyltransf_26; pfam13659 395095004646 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 395095004647 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 395095004648 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 395095004649 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 395095004650 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 395095004651 Histidine kinase; Region: HisKA_3; pfam07730 395095004652 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 395095004653 Ligand Binding Site [chemical binding]; other site 395095004654 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 395095004655 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 395095004656 putative substrate binding site [chemical binding]; other site 395095004657 putative ATP binding site [chemical binding]; other site 395095004658 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 395095004659 active site 395095004660 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 395095004661 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 395095004662 dimer interface [polypeptide binding]; other site 395095004663 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 395095004664 putative hydrophobic ligand binding site [chemical binding]; other site 395095004665 CLM binding site; other site 395095004666 L1 loop; other site 395095004667 DNA binding site [nucleotide binding] 395095004668 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 395095004669 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 395095004670 MDMPI C-terminal domain; Region: MDMPI_C; pfam07398 395095004671 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 395095004672 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 395095004673 nucleophile elbow; other site 395095004674 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 395095004675 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 395095004676 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 395095004677 Walker A/P-loop; other site 395095004678 ATP binding site [chemical binding]; other site 395095004679 Q-loop/lid; other site 395095004680 ABC transporter signature motif; other site 395095004681 Walker B; other site 395095004682 D-loop; other site 395095004683 H-loop/switch region; other site 395095004684 TOBE domain; Region: TOBE_2; pfam08402 395095004685 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 395095004686 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395095004687 dimer interface [polypeptide binding]; other site 395095004688 conserved gate region; other site 395095004689 putative PBP binding loops; other site 395095004690 ABC-ATPase subunit interface; other site 395095004691 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 395095004692 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395095004693 dimer interface [polypeptide binding]; other site 395095004694 conserved gate region; other site 395095004695 putative PBP binding loops; other site 395095004696 ABC-ATPase subunit interface; other site 395095004697 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 395095004698 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 395095004699 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 395095004700 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 395095004701 Isochorismatase family; Region: Isochorismatase; pfam00857 395095004702 catalytic triad [active] 395095004703 metal binding site [ion binding]; metal-binding site 395095004704 conserved cis-peptide bond; other site 395095004705 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 395095004706 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 395095004707 substrate binding pocket [chemical binding]; other site 395095004708 catalytic triad [active] 395095004709 hypothetical protein; Provisional; Region: PRK05865 395095004710 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395095004711 NAD(P) binding site [chemical binding]; other site 395095004712 active site 395095004713 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 395095004714 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 395095004715 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 395095004716 active site 395095004717 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 395095004718 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 395095004719 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 395095004720 30S ribosomal protein S18; Provisional; Region: PRK13401 395095004721 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 395095004722 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 395095004723 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 395095004724 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 395095004725 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 395095004726 intersubunit interface [polypeptide binding]; other site 395095004727 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 395095004728 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 395095004729 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 395095004730 precorrin-3B synthase; Region: CobG; TIGR02435 395095004731 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 395095004732 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 395095004733 active site 395095004734 SAM binding site [chemical binding]; other site 395095004735 homodimer interface [polypeptide binding]; other site 395095004736 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 395095004737 active site 395095004738 SAM binding site [chemical binding]; other site 395095004739 homodimer interface [polypeptide binding]; other site 395095004740 Methyltransferase domain; Region: Methyltransf_31; pfam13847 395095004741 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395095004742 S-adenosylmethionine binding site [chemical binding]; other site 395095004743 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 395095004744 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 395095004745 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 395095004746 precorrin-6x reductase; Region: precor6x_red; TIGR00715 395095004747 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 395095004748 active site 395095004749 putative homodimer interface [polypeptide binding]; other site 395095004750 SAM binding site [chemical binding]; other site 395095004751 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 395095004752 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 395095004753 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395095004754 NAD(P) binding site [chemical binding]; other site 395095004755 active site 395095004756 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 395095004757 Catalytic domain of uncharacterized Mycobacterium tuberculosis Rv2075c-like proteins; Region: PI-PLCc_Rv2075c_like; cd08590 395095004758 putative active site [active] 395095004759 catalytic site [active] 395095004760 putative metal binding site [ion binding]; other site 395095004761 C-type lectin (CTL)/C-type lectin-like (CTLD) domain; Region: CLECT; cl02432 395095004762 Protein of unknown function (DUF2563); Region: DUF2563; pfam10817 395095004763 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 395095004764 putative transposase OrfB; Reviewed; Region: PHA02517 395095004765 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 395095004766 Catalytic domain of Protein Kinases; Region: PKc; cd00180 395095004767 active site 395095004768 ATP binding site [chemical binding]; other site 395095004769 substrate binding site [chemical binding]; other site 395095004770 activation loop (A-loop); other site 395095004771 PknH-like extracellular domain; Region: PknH_C; pfam14032 395095004772 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 395095004773 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 395095004774 active site 395095004775 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 395095004776 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 395095004777 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 395095004778 ATP binding site [chemical binding]; other site 395095004779 putative Mg++ binding site [ion binding]; other site 395095004780 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 395095004781 nucleotide binding region [chemical binding]; other site 395095004782 ATP-binding site [chemical binding]; other site 395095004783 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 395095004784 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 395095004785 Predicted transcriptional regulator [Transcription]; Region: COG2378 395095004786 WYL domain; Region: WYL; pfam13280 395095004787 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 395095004788 Domain of unknown function (DUF222); Region: DUF222; pfam02720 395095004789 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 395095004790 active site 395095004791 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 395095004792 putative active site [active] 395095004793 PE family; Region: PE; pfam00934 395095004794 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 395095004795 PPE family; Region: PPE; pfam00823 395095004796 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 395095004797 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 395095004798 active site 395095004799 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 395095004800 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 395095004801 active site 395095004802 Pup-like protein; Region: Pup; pfam05639 395095004803 proteasome ATPase; Region: pup_AAA; TIGR03689 395095004804 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395095004805 Walker A motif; other site 395095004806 ATP binding site [chemical binding]; other site 395095004807 Walker B motif; other site 395095004808 arginine finger; other site 395095004809 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 395095004810 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550 395095004811 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 395095004812 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395095004813 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 395095004814 Predicted membrane protein [Function unknown]; Region: COG3918 395095004815 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 395095004816 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 395095004817 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 395095004818 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 395095004819 homodimer interface [polypeptide binding]; other site 395095004820 putative metal binding site [ion binding]; other site 395095004821 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 395095004822 PPE family; Region: PPE; pfam00823 395095004823 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 395095004824 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 395095004825 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 395095004826 substrate binding pocket [chemical binding]; other site 395095004827 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 395095004828 B12 binding site [chemical binding]; other site 395095004829 cobalt ligand [ion binding]; other site 395095004830 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 395095004831 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 395095004832 short chain dehydrogenase; Provisional; Region: PRK05872 395095004833 classical (c) SDRs; Region: SDR_c; cd05233 395095004834 NAD(P) binding site [chemical binding]; other site 395095004835 active site 395095004836 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 395095004837 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 395095004838 active site 395095004839 HIGH motif; other site 395095004840 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 395095004841 active site 395095004842 KMSKS motif; other site 395095004843 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 395095004844 putative tRNA binding surface [nucleotide binding]; other site 395095004845 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 395095004846 active site 395095004847 conserved hypothetical protein; Region: TIGR03847 395095004848 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 395095004849 catalytic core [active] 395095004850 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 395095004851 substrate binding site [chemical binding]; other site 395095004852 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 395095004853 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 395095004854 active site 395095004855 DivIVA domain; Region: DivI1A_domain; TIGR03544 395095004856 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 395095004857 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 395095004858 Predicted integral membrane protein [Function unknown]; Region: COG0762 395095004859 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 395095004860 Predicted enzyme with a TIM-barrel fold [General function prediction only]; Region: COG0325 395095004861 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 395095004862 catalytic residue [active] 395095004863 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 395095004864 uncharacterized protein, YfiH family; Region: TIGR00726 395095004865 cell division protein FtsZ; Validated; Region: PRK09330 395095004866 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 395095004867 nucleotide binding site [chemical binding]; other site 395095004868 SulA interaction site; other site 395095004869 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 395095004870 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 395095004871 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 395095004872 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 395095004873 cell division protein FtsW; Region: ftsW; TIGR02614 395095004874 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 395095004875 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 395095004876 Mg++ binding site [ion binding]; other site 395095004877 putative catalytic motif [active] 395095004878 putative substrate binding site [chemical binding]; other site 395095004879 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 395095004880 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 395095004881 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 395095004882 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 395095004883 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 395095004884 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 395095004885 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 395095004886 MraW methylase family; Region: Methyltransf_5; pfam01795 395095004887 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 395095004888 MraZ protein; Region: MraZ; pfam02381 395095004889 MraZ protein; Region: MraZ; pfam02381 395095004890 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 395095004891 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 395095004892 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 395095004893 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 395095004894 substrate binding pocket [chemical binding]; other site 395095004895 chain length determination region; other site 395095004896 substrate-Mg2+ binding site; other site 395095004897 catalytic residues [active] 395095004898 aspartate-rich region 1; other site 395095004899 active site lid residues [active] 395095004900 aspartate-rich region 2; other site 395095004901 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 395095004902 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 395095004903 Catalytic domain of Protein Kinases; Region: PKc; cd00180 395095004904 active site 395095004905 ATP binding site [chemical binding]; other site 395095004906 substrate binding site [chemical binding]; other site 395095004907 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 395095004908 substrate binding site [chemical binding]; other site 395095004909 activation loop (A-loop); other site 395095004910 activation loop (A-loop); other site 395095004911 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 395095004912 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 395095004913 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG3200 395095004914 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 395095004915 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 395095004916 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 395095004917 putative acyl-acceptor binding pocket; other site 395095004918 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 395095004919 putative hydrophobic ligand binding site [chemical binding]; other site 395095004920 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 395095004921 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 395095004922 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 395095004923 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 395095004924 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 395095004925 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 395095004926 Subunit I/III interface [polypeptide binding]; other site 395095004927 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 395095004928 Cytochrome c; Region: Cytochrom_C; pfam00034 395095004929 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 395095004930 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 395095004931 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 395095004932 iron-sulfur cluster [ion binding]; other site 395095004933 [2Fe-2S] cluster binding site [ion binding]; other site 395095004934 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 395095004935 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 395095004936 heme bH binding site [chemical binding]; other site 395095004937 intrachain domain interface; other site 395095004938 heme bL binding site [chemical binding]; other site 395095004939 interchain domain interface [polypeptide binding]; other site 395095004940 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 395095004941 Qo binding site; other site 395095004942 Protein of unknown function (DUF2561); Region: DUF2561; pfam10812 395095004943 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 395095004944 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 395095004945 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 395095004946 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 395095004947 dimer interface [polypeptide binding]; other site 395095004948 active site 395095004949 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 395095004950 Ligand Binding Site [chemical binding]; other site 395095004951 Molecular Tunnel; other site 395095004952 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 395095004953 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 395095004954 substrate binding site [chemical binding]; other site 395095004955 ATP binding site [chemical binding]; other site 395095004956 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 395095004957 Glycerate kinase family; Region: Gly_kinase; cl00841 395095004958 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 395095004959 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 395095004960 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 395095004961 putative dimer interface [polypeptide binding]; other site 395095004962 active site pocket [active] 395095004963 putative cataytic base [active] 395095004964 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 395095004965 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 395095004966 homodimer interface [polypeptide binding]; other site 395095004967 substrate-cofactor binding pocket; other site 395095004968 catalytic residue [active] 395095004969 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 395095004970 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 395095004971 cyclase homology domain; Region: CHD; cd07302 395095004972 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 395095004973 nucleotidyl binding site; other site 395095004974 metal binding site [ion binding]; metal-binding site 395095004975 dimer interface [polypeptide binding]; other site 395095004976 multifunctional aminopeptidase A; Provisional; Region: PRK00913 395095004977 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 395095004978 interface (dimer of trimers) [polypeptide binding]; other site 395095004979 Substrate-binding/catalytic site; other site 395095004980 Zn-binding sites [ion binding]; other site 395095004981 short chain dehydrogenase; Validated; Region: PRK05855 395095004982 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 395095004983 classical (c) SDRs; Region: SDR_c; cd05233 395095004984 NAD(P) binding site [chemical binding]; other site 395095004985 active site 395095004986 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 395095004987 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 395095004988 E3 interaction surface; other site 395095004989 lipoyl attachment site [posttranslational modification]; other site 395095004990 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 395095004991 E3 interaction surface; other site 395095004992 lipoyl attachment site [posttranslational modification]; other site 395095004993 e3 binding domain; Region: E3_binding; pfam02817 395095004994 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 395095004995 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 395095004996 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 395095004997 putative NAD(P) binding site [chemical binding]; other site 395095004998 putative active site [active] 395095004999 lipoate-protein ligase B; Provisional; Region: PRK14345 395095005000 lipoyl synthase; Provisional; Region: PRK05481 395095005001 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 395095005002 FeS/SAM binding site; other site 395095005003 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 395095005004 RDD family; Region: RDD; pfam06271 395095005005 glutamine synthetase, type I; Region: GlnA; TIGR00653 395095005006 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 395095005007 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 395095005008 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 395095005009 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 395095005010 metal binding triad; other site 395095005011 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 395095005012 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 395095005013 metal binding triad; other site 395095005014 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 395095005015 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 395095005016 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 395095005017 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 395095005018 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 395095005019 TAP-like protein; Region: Abhydrolase_4; pfam08386 395095005020 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 395095005021 TAP-like protein; Region: Abhydrolase_4; pfam08386 395095005022 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 395095005023 putative active site; other site 395095005024 putative metal binding residues [ion binding]; other site 395095005025 signature motif; other site 395095005026 putative triphosphate binding site [ion binding]; other site 395095005027 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 395095005028 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 395095005029 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 395095005030 RNA/DNA hybrid binding site [nucleotide binding]; other site 395095005031 active site 395095005032 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 395095005033 catalytic core [active] 395095005034 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 395095005035 Putative zinc ribbon domain; Region: DUF164; pfam02591 395095005036 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 395095005037 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 395095005038 Uncharacterized conserved protein [Function unknown]; Region: COG0327 395095005039 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 395095005040 hypothetical protein; Provisional; Region: PRK07908 395095005041 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 395095005042 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395095005043 homodimer interface [polypeptide binding]; other site 395095005044 catalytic residue [active] 395095005045 Low molecular weight phosphatase family; Region: LMWPc; cd00115 395095005046 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 395095005047 active site 395095005048 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 395095005049 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 395095005050 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 395095005051 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 395095005052 dimer interface [polypeptide binding]; other site 395095005053 catalytic triad [active] 395095005054 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 395095005055 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 395095005056 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 395095005057 dimer interface [polypeptide binding]; other site 395095005058 TPP-binding site [chemical binding]; other site 395095005059 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 395095005060 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 395095005061 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 395095005062 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 395095005063 acyl carrier protein; Provisional; Region: acpP; PRK00982 395095005064 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 395095005065 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 395095005066 dimer interface [polypeptide binding]; other site 395095005067 active site 395095005068 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 395095005069 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 395095005070 dimer interface [polypeptide binding]; other site 395095005071 active site 395095005072 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 395095005073 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 395095005074 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 395095005075 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 395095005076 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 395095005077 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 395095005078 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 395095005079 FAD binding domain; Region: FAD_binding_4; pfam01565 395095005080 diacylglycerol kinase; Reviewed; Region: PRK11914 395095005081 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 395095005082 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 395095005083 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 395095005084 Beta-lactamase; Region: Beta-lactamase; pfam00144 395095005085 Methyltransferase domain; Region: Methyltransf_31; pfam13847 395095005086 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395095005087 S-adenosylmethionine binding site [chemical binding]; other site 395095005088 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 395095005089 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 395095005090 NAD binding site [chemical binding]; other site 395095005091 catalytic Zn binding site [ion binding]; other site 395095005092 substrate binding site [chemical binding]; other site 395095005093 structural Zn binding site [ion binding]; other site 395095005094 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 395095005095 short chain dehydrogenase; Provisional; Region: PRK05854 395095005096 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 395095005097 putative NAD(P) binding site [chemical binding]; other site 395095005098 active site 395095005099 Major Facilitator Superfamily; Region: MFS_1; pfam07690 395095005100 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 395095005101 Cytochrome P450; Region: p450; cl12078 395095005102 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 395095005103 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 395095005104 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 395095005105 Transcriptional regulator [Transcription]; Region: LysR; COG0583 395095005106 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 395095005107 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 395095005108 dimerization interface [polypeptide binding]; other site 395095005109 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 395095005110 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 395095005111 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 395095005112 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 395095005113 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 395095005114 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 395095005115 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 395095005116 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 395095005117 CDP-diacylglycerol pyrophosphatase [Lipid metabolism]; Region: Cdh; COG2134 395095005118 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 395095005119 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 395095005120 active site residue [active] 395095005121 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 395095005122 active site residue [active] 395095005123 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 395095005124 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 395095005125 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 395095005126 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395095005127 homodimer interface [polypeptide binding]; other site 395095005128 catalytic residue [active] 395095005129 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3196 395095005130 heat shock protein 90; Provisional; Region: PRK05218 395095005131 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395095005132 ATP binding site [chemical binding]; other site 395095005133 Mg2+ binding site [ion binding]; other site 395095005134 G-X-G motif; other site 395095005135 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 395095005136 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 395095005137 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 395095005138 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 395095005139 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 395095005140 Uncharacterized conserved protein [Function unknown]; Region: COG2442 395095005141 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 395095005142 DNA binding site [nucleotide binding] 395095005143 active site 395095005144 Int/Topo IB signature motif; other site 395095005145 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 395095005146 DNA binding residues [nucleotide binding] 395095005147 Uncharacterized conserved protein [Function unknown]; Region: COG2128 395095005148 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 395095005149 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 395095005150 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395095005151 putative PBP binding loops; other site 395095005152 ABC-ATPase subunit interface; other site 395095005153 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 395095005154 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395095005155 dimer interface [polypeptide binding]; other site 395095005156 conserved gate region; other site 395095005157 putative PBP binding loops; other site 395095005158 ABC-ATPase subunit interface; other site 395095005159 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 395095005160 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 395095005161 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 395095005162 Ligand Binding Site [chemical binding]; other site 395095005163 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 395095005164 Ligand Binding Site [chemical binding]; other site 395095005165 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 395095005166 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 395095005167 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 395095005168 catalytic residue [active] 395095005169 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 395095005170 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 395095005171 Amidinotransferase; Region: Amidinotransf; pfam02274 395095005172 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 395095005173 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 395095005174 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 395095005175 putative DNA binding site [nucleotide binding]; other site 395095005176 putative Zn2+ binding site [ion binding]; other site 395095005177 AsnC family; Region: AsnC_trans_reg; pfam01037 395095005178 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 395095005179 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 395095005180 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 395095005181 Walker A/P-loop; other site 395095005182 ATP binding site [chemical binding]; other site 395095005183 Q-loop/lid; other site 395095005184 ABC transporter signature motif; other site 395095005185 Walker B; other site 395095005186 D-loop; other site 395095005187 H-loop/switch region; other site 395095005188 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 395095005189 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 395095005190 Walker A/P-loop; other site 395095005191 ATP binding site [chemical binding]; other site 395095005192 Q-loop/lid; other site 395095005193 ABC transporter signature motif; other site 395095005194 Walker B; other site 395095005195 D-loop; other site 395095005196 H-loop/switch region; other site 395095005197 MarR family; Region: MarR; pfam01047 395095005198 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 395095005199 PE family; Region: PE; pfam00934 395095005200 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 395095005201 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 395095005202 putative substrate translocation pore; other site 395095005203 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 395095005204 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 395095005205 malate dehydrogenase; Provisional; Region: PRK13529 395095005206 Malic enzyme, N-terminal domain; Region: malic; pfam00390 395095005207 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 395095005208 NAD(P) binding site [chemical binding]; other site 395095005209 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 395095005210 Major Facilitator Superfamily; Region: MFS_1; pfam07690 395095005211 putative substrate translocation pore; other site 395095005212 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 395095005213 putative substrate translocation pore; other site 395095005214 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 395095005215 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 395095005216 dimer interface [polypeptide binding]; other site 395095005217 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395095005218 catalytic residue [active] 395095005219 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 395095005220 serine O-acetyltransferase; Region: cysE; TIGR01172 395095005221 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 395095005222 trimer interface [polypeptide binding]; other site 395095005223 active site 395095005224 substrate binding site [chemical binding]; other site 395095005225 CoA binding site [chemical binding]; other site 395095005226 putative transposase OrfB; Reviewed; Region: PHA02517 395095005227 HTH-like domain; Region: HTH_21; pfam13276 395095005228 Integrase core domain; Region: rve; pfam00665 395095005229 Integrase core domain; Region: rve_3; pfam13683 395095005230 hypothetical protein; Provisional; Region: PRK14851 395095005231 hypothetical protein; Validated; Region: PRK08223 395095005232 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 395095005233 ATP binding site [chemical binding]; other site 395095005234 substrate interface [chemical binding]; other site 395095005235 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 395095005236 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 395095005237 Zn2+ binding site [ion binding]; other site 395095005238 Mg2+ binding site [ion binding]; other site 395095005239 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 395095005240 Repair protein; Region: Repair_PSII; pfam04536 395095005241 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 395095005242 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 395095005243 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 395095005244 Phosphoesterase family; Region: Phosphoesterase; pfam04185 395095005245 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 395095005246 PPE family; Region: PPE; pfam00823 395095005247 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 395095005248 Transposase; Region: HTH_Tnp_1; cl17663 395095005249 putative transposase OrfB; Reviewed; Region: PHA02517 395095005250 HTH-like domain; Region: HTH_21; pfam13276 395095005251 Integrase core domain; Region: rve; pfam00665 395095005252 Integrase core domain; Region: rve_3; pfam13683 395095005253 glycyl-tRNA synthetase; Provisional; Region: PRK04173 395095005254 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 395095005255 motif 1; other site 395095005256 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 395095005257 active site 395095005258 motif 2; other site 395095005259 motif 3; other site 395095005260 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 395095005261 anticodon binding site; other site 395095005262 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 395095005263 dimerization interface [polypeptide binding]; other site 395095005264 putative DNA binding site [nucleotide binding]; other site 395095005265 putative Zn2+ binding site [ion binding]; other site 395095005266 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 395095005267 metal binding site 2 [ion binding]; metal-binding site 395095005268 putative DNA binding helix; other site 395095005269 metal binding site 1 [ion binding]; metal-binding site 395095005270 dimer interface [polypeptide binding]; other site 395095005271 structural Zn2+ binding site [ion binding]; other site 395095005272 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 395095005273 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 395095005274 catalytic residue [active] 395095005275 putative FPP diphosphate binding site; other site 395095005276 putative FPP binding hydrophobic cleft; other site 395095005277 dimer interface [polypeptide binding]; other site 395095005278 putative IPP diphosphate binding site; other site 395095005279 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 395095005280 Recombination protein O N terminal; Region: RecO_N; pfam11967 395095005281 Recombination protein O C terminal; Region: RecO_C; pfam02565 395095005282 amidase; Provisional; Region: PRK06061 395095005283 Amidase; Region: Amidase; pfam01425 395095005284 GTPase Era; Reviewed; Region: era; PRK00089 395095005285 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 395095005286 G1 box; other site 395095005287 GTP/Mg2+ binding site [chemical binding]; other site 395095005288 Switch I region; other site 395095005289 G2 box; other site 395095005290 Switch II region; other site 395095005291 G3 box; other site 395095005292 G4 box; other site 395095005293 G5 box; other site 395095005294 KH domain; Region: KH_2; pfam07650 395095005295 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 395095005296 Domain of unknown function DUF21; Region: DUF21; pfam01595 395095005297 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 395095005298 Transporter associated domain; Region: CorC_HlyC; smart01091 395095005299 K homology RNA-binding domain; Region: KH; smart00322 395095005300 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 395095005301 PhoH-like protein; Region: PhoH; pfam02562 395095005302 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 395095005303 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 395095005304 RNA methyltransferase, RsmE family; Region: TIGR00046 395095005305 chaperone protein DnaJ; Provisional; Region: PRK14278 395095005306 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 395095005307 HSP70 interaction site [polypeptide binding]; other site 395095005308 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 395095005309 Zn binding sites [ion binding]; other site 395095005310 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 395095005311 dimer interface [polypeptide binding]; other site 395095005312 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 395095005313 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 395095005314 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 395095005315 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 395095005316 Condensation domain; Region: Condensation; pfam00668 395095005317 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 395095005318 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 395095005319 acyl-activating enzyme (AAE) consensus motif; other site 395095005320 AMP binding site [chemical binding]; other site 395095005321 Condensation domain; Region: Condensation; pfam00668 395095005322 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 395095005323 Condensation domain; Region: Condensation; pfam00668 395095005324 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 395095005325 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 395095005326 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 395095005327 acyl-activating enzyme (AAE) consensus motif; other site 395095005328 AMP binding site [chemical binding]; other site 395095005329 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 395095005330 Condensation domain; Region: Condensation; pfam00668 395095005331 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 395095005332 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 395095005333 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 395095005334 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 395095005335 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 395095005336 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 395095005337 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 395095005338 NADP binding site [chemical binding]; other site 395095005339 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 395095005340 active site 395095005341 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 395095005342 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 395095005343 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 395095005344 active site 395095005345 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 395095005346 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 395095005347 acyl-activating enzyme (AAE) consensus motif; other site 395095005348 active site 395095005349 AMP binding site [chemical binding]; other site 395095005350 substrate binding site [chemical binding]; other site 395095005351 salicylate synthase MbtI; Reviewed; Region: PRK07912 395095005352 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 395095005353 Predicted permease [General function prediction only]; Region: COG3329 395095005354 coproporphyrinogen III oxidase; Validated; Region: PRK05628 395095005355 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 395095005356 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 395095005357 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 395095005358 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 395095005359 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 395095005360 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 395095005361 Active Sites [active] 395095005362 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 395095005363 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 395095005364 Predicted membrane protein [Function unknown]; Region: COG1297 395095005365 putative oligopeptide transporter, OPT family; Region: TIGR00733 395095005366 sulfate transport protein; Provisional; Region: cysT; CHL00187 395095005367 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395095005368 dimer interface [polypeptide binding]; other site 395095005369 conserved gate region; other site 395095005370 putative PBP binding loops; other site 395095005371 ABC-ATPase subunit interface; other site 395095005372 sulfate transport protein; Provisional; Region: cysT; CHL00187 395095005373 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395095005374 dimer interface [polypeptide binding]; other site 395095005375 conserved gate region; other site 395095005376 putative PBP binding loops; other site 395095005377 ABC-ATPase subunit interface; other site 395095005378 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 395095005379 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 395095005380 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 395095005381 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 395095005382 PknH-like extracellular domain; Region: PknH_C; pfam14032 395095005383 GTP-binding protein LepA; Provisional; Region: PRK05433 395095005384 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 395095005385 G1 box; other site 395095005386 putative GEF interaction site [polypeptide binding]; other site 395095005387 GTP/Mg2+ binding site [chemical binding]; other site 395095005388 Switch I region; other site 395095005389 G2 box; other site 395095005390 G3 box; other site 395095005391 Switch II region; other site 395095005392 G4 box; other site 395095005393 G5 box; other site 395095005394 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 395095005395 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 395095005396 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 395095005397 ribonuclease Z; Reviewed; Region: PRK00055 395095005398 PE family; Region: PE; pfam00934 395095005399 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 395095005400 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 395095005401 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 395095005402 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 395095005403 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 395095005404 Uncharacterized conserved protein [Function unknown]; Region: COG2308 395095005405 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 395095005406 hypothetical protein; Reviewed; Region: PRK07914 395095005407 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 395095005408 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 395095005409 Competence protein; Region: Competence; pfam03772 395095005410 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 395095005411 Helix-hairpin-helix motif; Region: HHH; pfam00633 395095005412 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 395095005413 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 395095005414 Coenzyme A binding pocket [chemical binding]; other site 395095005415 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 395095005416 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 395095005417 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 395095005418 active site 395095005419 catalytic triad [active] 395095005420 oxyanion hole [active] 395095005421 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 395095005422 catalytic core [active] 395095005423 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 395095005424 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 395095005425 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 395095005426 active site 395095005427 (T/H)XGH motif; other site 395095005428 Methyltransferase domain; Region: Methyltransf_23; pfam13489 395095005429 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395095005430 S-adenosylmethionine binding site [chemical binding]; other site 395095005431 Transposase; Region: DEDD_Tnp_IS110; pfam01548 395095005432 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 395095005433 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 395095005434 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 395095005435 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 395095005436 metal ion-dependent adhesion site (MIDAS); other site 395095005437 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 395095005438 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395095005439 Walker A motif; other site 395095005440 ATP binding site [chemical binding]; other site 395095005441 Walker B motif; other site 395095005442 arginine finger; other site 395095005443 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 395095005444 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 395095005445 putative catalytic cysteine [active] 395095005446 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 395095005447 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 395095005448 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 395095005449 dimer interface [polypeptide binding]; other site 395095005450 decamer (pentamer of dimers) interface [polypeptide binding]; other site 395095005451 catalytic triad [active] 395095005452 peroxidatic and resolving cysteines [active] 395095005453 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 395095005454 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 395095005455 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 395095005456 PPE family; Region: PPE; pfam00823 395095005457 PE family; Region: PE; pfam00934 395095005458 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 395095005459 Mechanosensitive ion channel; Region: MS_channel; pfam00924 395095005460 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 395095005461 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 395095005462 ligand binding site [chemical binding]; other site 395095005463 flexible hinge region; other site 395095005464 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 395095005465 dimerization interface [polypeptide binding]; other site 395095005466 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 395095005467 cyclase homology domain; Region: CHD; cd07302 395095005468 nucleotidyl binding site; other site 395095005469 metal binding site [ion binding]; metal-binding site 395095005470 dimer interface [polypeptide binding]; other site 395095005471 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 395095005472 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 395095005473 substrate binding site [chemical binding]; other site 395095005474 dimer interface [polypeptide binding]; other site 395095005475 ATP binding site [chemical binding]; other site 395095005476 NAD synthetase; Reviewed; Region: nadE; PRK02628 395095005477 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 395095005478 multimer interface [polypeptide binding]; other site 395095005479 active site 395095005480 catalytic triad [active] 395095005481 protein interface 1 [polypeptide binding]; other site 395095005482 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 395095005483 homodimer interface [polypeptide binding]; other site 395095005484 NAD binding pocket [chemical binding]; other site 395095005485 ATP binding pocket [chemical binding]; other site 395095005486 Mg binding site [ion binding]; other site 395095005487 active-site loop [active] 395095005488 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 395095005489 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 395095005490 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 395095005491 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 395095005492 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 395095005493 active site 395095005494 multimer interface [polypeptide binding]; other site 395095005495 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 395095005496 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 395095005497 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 395095005498 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 395095005499 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 395095005500 active site 395095005501 HIGH motif; other site 395095005502 nucleotide binding site [chemical binding]; other site 395095005503 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 395095005504 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 395095005505 active site 395095005506 KMSKS motif; other site 395095005507 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 395095005508 tRNA binding surface [nucleotide binding]; other site 395095005509 anticodon binding site; other site 395095005510 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 395095005511 Uncharacterized conserved protein [Function unknown]; Region: COG3268 395095005512 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 395095005513 NAD(P) binding pocket [chemical binding]; other site 395095005514 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 395095005515 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 395095005516 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 395095005517 GTP binding site; other site 395095005518 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 395095005519 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 395095005520 TPP-binding site [chemical binding]; other site 395095005521 Major Facilitator Superfamily; Region: MFS_1; pfam07690 395095005522 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 395095005523 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 395095005524 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395095005525 Walker A motif; other site 395095005526 ATP binding site [chemical binding]; other site 395095005527 Walker B motif; other site 395095005528 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 395095005529 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 395095005530 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 395095005531 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 395095005532 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 395095005533 oligomer interface [polypeptide binding]; other site 395095005534 active site residues [active] 395095005535 Clp protease; Region: CLP_protease; pfam00574 395095005536 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 395095005537 oligomer interface [polypeptide binding]; other site 395095005538 active site residues [active] 395095005539 trigger factor; Provisional; Region: tig; PRK01490 395095005540 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 395095005541 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 395095005542 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 395095005543 Beta-lactamase; Region: Beta-lactamase; pfam00144 395095005544 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 395095005545 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 395095005546 putative DNA binding site [nucleotide binding]; other site 395095005547 catalytic residue [active] 395095005548 putative H2TH interface [polypeptide binding]; other site 395095005549 putative catalytic residues [active] 395095005550 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 395095005551 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 395095005552 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 395095005553 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 395095005554 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 395095005555 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 395095005556 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 395095005557 active site 395095005558 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 395095005559 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 395095005560 active site 395095005561 catalytic site [active] 395095005562 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 395095005563 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 395095005564 active site 395095005565 NAD-specific glutamate dehydrogenase [Amino acid transport and metabolism]; Region: COG2902 395095005566 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 395095005567 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 395095005568 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 395095005569 ABC transporter; Region: ABC_tran_2; pfam12848 395095005570 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 395095005571 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 395095005572 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 395095005573 dimer interface [polypeptide binding]; other site 395095005574 ssDNA binding site [nucleotide binding]; other site 395095005575 tetramer (dimer of dimers) interface [polypeptide binding]; other site 395095005576 glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355 395095005577 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 395095005578 putative acyl-acceptor binding pocket; other site 395095005579 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 395095005580 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 395095005581 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 395095005582 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 395095005583 putative acyl-acceptor binding pocket; other site 395095005584 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 395095005585 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 395095005586 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 395095005587 enoyl-CoA hydratase; Provisional; Region: PRK05870 395095005588 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 395095005589 substrate binding site [chemical binding]; other site 395095005590 oxyanion hole (OAH) forming residues; other site 395095005591 trimer interface [polypeptide binding]; other site 395095005592 TIGR00725 family protein; Region: TIGR00725 395095005593 thymidylate synthase; Provisional; Region: thyA; PRK00956 395095005594 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 395095005595 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 395095005596 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 395095005597 E3 interaction surface; other site 395095005598 lipoyl attachment site [posttranslational modification]; other site 395095005599 e3 binding domain; Region: E3_binding; pfam02817 395095005600 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 395095005601 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 395095005602 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 395095005603 alpha subunit interface [polypeptide binding]; other site 395095005604 TPP binding site [chemical binding]; other site 395095005605 heterodimer interface [polypeptide binding]; other site 395095005606 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 395095005607 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 395095005608 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 395095005609 tetramer interface [polypeptide binding]; other site 395095005610 TPP-binding site [chemical binding]; other site 395095005611 heterodimer interface [polypeptide binding]; other site 395095005612 phosphorylation loop region [posttranslational modification] 395095005613 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 395095005614 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 395095005615 putative active site [active] 395095005616 putative catalytic site [active] 395095005617 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 395095005618 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 395095005619 active site 395095005620 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 395095005621 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 395095005622 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 395095005623 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 395095005624 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 395095005625 AMP-binding domain protein; Validated; Region: PRK08315 395095005626 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 395095005627 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 395095005628 acyl-activating enzyme (AAE) consensus motif; other site 395095005629 acyl-activating enzyme (AAE) consensus motif; other site 395095005630 putative AMP binding site [chemical binding]; other site 395095005631 putative active site [active] 395095005632 putative CoA binding site [chemical binding]; other site 395095005633 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 395095005634 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 395095005635 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 395095005636 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 395095005637 classical (c) SDRs; Region: SDR_c; cd05233 395095005638 NAD(P) binding site [chemical binding]; other site 395095005639 active site 395095005640 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 395095005641 catalytic site [active] 395095005642 putative active site [active] 395095005643 putative substrate binding site [chemical binding]; other site 395095005644 dimer interface [polypeptide binding]; other site 395095005645 Domain of unknown function (DUF4411); Region: DUF4411; pfam14367 395095005646 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 395095005647 non-specific DNA binding site [nucleotide binding]; other site 395095005648 salt bridge; other site 395095005649 sequence-specific DNA binding site [nucleotide binding]; other site 395095005650 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 395095005651 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893 395095005652 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 395095005653 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 395095005654 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 395095005655 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 395095005656 PE family; Region: PE; pfam00934 395095005657 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 395095005658 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 395095005659 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 395095005660 catalytic triad [active] 395095005661 hypothetical protein; Provisional; Region: PRK07907 395095005662 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 395095005663 active site 395095005664 metal binding site [ion binding]; metal-binding site 395095005665 dimer interface [polypeptide binding]; other site 395095005666 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 395095005667 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 395095005668 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 395095005669 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 395095005670 phosphate binding site [ion binding]; other site 395095005671 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 395095005672 FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447 395095005673 putative active site [active] 395095005674 putative catalytic site [active] 395095005675 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 395095005676 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 395095005677 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 395095005678 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 395095005679 putative NAD(P) binding site [chemical binding]; other site 395095005680 active site 395095005681 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 395095005682 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 395095005683 active site 395095005684 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 395095005685 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 395095005686 putative active site [active] 395095005687 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 395095005688 Mrr N-terminal domain; Region: Mrr_N; pfam14338 395095005689 Restriction endonuclease; Region: Mrr_cat; pfam04471 395095005690 ERCC4 domain; Region: ERCC4; pfam02732 395095005691 Lsr2; Region: Lsr2; pfam11774 395095005692 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 395095005693 putative active site [active] 395095005694 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 395095005695 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 395095005696 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 395095005697 catalytic residue [active] 395095005698 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 395095005699 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 395095005700 putative RNA binding site [nucleotide binding]; other site 395095005701 elongation factor P; Validated; Region: PRK00529 395095005702 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 395095005703 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 395095005704 RNA binding site [nucleotide binding]; other site 395095005705 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 395095005706 RNA binding site [nucleotide binding]; other site 395095005707 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 395095005708 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 395095005709 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 395095005710 active site 395095005711 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 395095005712 Dehydroquinase class II; Region: DHquinase_II; pfam01220 395095005713 trimer interface [polypeptide binding]; other site 395095005714 active site 395095005715 dimer interface [polypeptide binding]; other site 395095005716 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 395095005717 active site 395095005718 dimer interface [polypeptide binding]; other site 395095005719 metal binding site [ion binding]; metal-binding site 395095005720 shikimate kinase; Reviewed; Region: aroK; PRK00131 395095005721 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 395095005722 ADP binding site [chemical binding]; other site 395095005723 magnesium binding site [ion binding]; other site 395095005724 putative shikimate binding site; other site 395095005725 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 395095005726 digalactosyldiacylglycerol synthase; Region: PLN02846 395095005727 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 395095005728 putative active site [active] 395095005729 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 395095005730 oligomeric interface; other site 395095005731 putative active site [active] 395095005732 homodimer interface [polypeptide binding]; other site 395095005733 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402 395095005734 putative active site [active] 395095005735 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 395095005736 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 395095005737 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 395095005738 shikimate-5-dehydrogenase, fungal AROM-type; Region: Shik-DH-AROM; TIGR01809 395095005739 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 395095005740 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 395095005741 NAD(P) binding site [chemical binding]; other site 395095005742 shikimate binding site; other site 395095005743 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 395095005744 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 395095005745 dimerization interface [polypeptide binding]; other site 395095005746 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 395095005747 Uncharacterized conserved protein [Function unknown]; Region: COG0432 395095005748 Predicted integral membrane protein [Function unknown]; Region: COG5473 395095005749 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 395095005750 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 395095005751 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 395095005752 Walker A/P-loop; other site 395095005753 ATP binding site [chemical binding]; other site 395095005754 Q-loop/lid; other site 395095005755 ABC transporter signature motif; other site 395095005756 Walker B; other site 395095005757 D-loop; other site 395095005758 H-loop/switch region; other site 395095005759 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 395095005760 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 395095005761 ligand binding site [chemical binding]; other site 395095005762 flexible hinge region; other site 395095005763 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 395095005764 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 395095005765 ligand binding site [chemical binding]; other site 395095005766 flexible hinge region; other site 395095005767 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 395095005768 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 395095005769 active site 395095005770 nucleophile elbow; other site 395095005771 Uncharacterized conserved protein [Function unknown]; Region: COG2308 395095005772 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 395095005773 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 395095005774 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 395095005775 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 395095005776 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 395095005777 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 395095005778 Transglutaminase/protease-like homologues; Region: TGc; smart00460 395095005779 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3801 395095005780 Predicted membrane protein [Function unknown]; Region: COG4129 395095005781 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 395095005782 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 395095005783 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 395095005784 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 395095005785 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 395095005786 putative hydrophobic ligand binding site [chemical binding]; other site 395095005787 protein interface [polypeptide binding]; other site 395095005788 gate; other site 395095005789 Predicted metalloprotease [General function prediction only]; Region: COG2321 395095005790 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 395095005791 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 395095005792 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 395095005793 active site 395095005794 metal binding site [ion binding]; metal-binding site 395095005795 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 395095005796 haloalkane dehalogenase; Provisional; Region: PRK03592 395095005797 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 395095005798 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 395095005799 dimer interface [polypeptide binding]; other site 395095005800 motif 1; other site 395095005801 active site 395095005802 motif 2; other site 395095005803 motif 3; other site 395095005804 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 395095005805 anticodon binding site; other site 395095005806 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 395095005807 active site 395095005808 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 395095005809 active site 395095005810 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 395095005811 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 395095005812 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 395095005813 Protein export membrane protein; Region: SecD_SecF; pfam02355 395095005814 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05886 395095005815 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 395095005816 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 395095005817 inhibitor-cofactor binding pocket; inhibition site 395095005818 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395095005819 catalytic residue [active] 395095005820 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 395095005821 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 395095005822 acyl-activating enzyme (AAE) consensus motif; other site 395095005823 AMP binding site [chemical binding]; other site 395095005824 active site 395095005825 CoA binding site [chemical binding]; other site 395095005826 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 395095005827 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 395095005828 putative NAD(P) binding site [chemical binding]; other site 395095005829 active site 395095005830 putative substrate binding site [chemical binding]; other site 395095005831 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 395095005832 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395095005833 Walker A motif; other site 395095005834 ATP binding site [chemical binding]; other site 395095005835 Walker B motif; other site 395095005836 arginine finger; other site 395095005837 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 395095005838 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 395095005839 RuvA N terminal domain; Region: RuvA_N; pfam01330 395095005840 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 395095005841 active site 395095005842 putative DNA-binding cleft [nucleotide binding]; other site 395095005843 dimer interface [polypeptide binding]; other site 395095005844 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 395095005845 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 395095005846 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 395095005847 putative active site [active] 395095005848 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 395095005849 Protein of unknown function DUF2617; Region: DUF2617; pfam10936 395095005850 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 395095005851 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 395095005852 Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only]; Region: COG4262 395095005853 Spermine/spermidine synthase; Region: Spermine_synth; pfam01564 395095005854 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 395095005855 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 395095005856 hypothetical protein; Validated; Region: PRK00110 395095005857 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 395095005858 predicted active site [active] 395095005859 catalytic triad [active] 395095005860 acyl-CoA thioesterase II; Region: tesB; TIGR00189 395095005861 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 395095005862 active site 395095005863 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 395095005864 catalytic triad [active] 395095005865 dimer interface [polypeptide binding]; other site 395095005866 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 395095005867 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 395095005868 active site 395095005869 multimer interface [polypeptide binding]; other site 395095005870 Pyridoxamine-phosphate oxidase [Coenzyme metabolism]; Region: PdxH; COG0259 395095005871 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 395095005872 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 395095005873 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 395095005874 PPE family; Region: PPE; pfam00823 395095005875 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 395095005876 PE-PPE domain; Region: PE-PPE; pfam08237 395095005877 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 395095005878 nudix motif; other site 395095005879 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 395095005880 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 395095005881 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 395095005882 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 395095005883 putative acyl-acceptor binding pocket; other site 395095005884 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 395095005885 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 395095005886 nucleotide binding site/active site [active] 395095005887 HIT family signature motif; other site 395095005888 catalytic residue [active] 395095005889 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4762 395095005890 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 395095005891 Predicted transcriptional regulator [Transcription]; Region: COG2345 395095005892 Helix-turn-helix domain; Region: HTH_20; pfam12840 395095005893 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395095005894 S-adenosylmethionine binding site [chemical binding]; other site 395095005895 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 395095005896 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 395095005897 Ligand Binding Site [chemical binding]; other site 395095005898 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 395095005899 Ligand Binding Site [chemical binding]; other site 395095005900 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 395095005901 Ligand Binding Site [chemical binding]; other site 395095005902 Universal stress protein family; Region: Usp; pfam00582 395095005903 Ligand Binding Site [chemical binding]; other site 395095005904 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 395095005905 active site 395095005906 Peptidase family M50; Region: Peptidase_M50; pfam02163 395095005907 putative substrate binding region [chemical binding]; other site 395095005908 FOG: CBS domain [General function prediction only]; Region: COG0517 395095005909 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 395095005910 FOG: CBS domain [General function prediction only]; Region: COG0517 395095005911 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 395095005912 peptide chain release factor 1; Provisional; Region: PRK04011 395095005913 SHS2 domain protein implicated in nucleic acid metabolism [General function prediction only]; Region: COG1371 395095005914 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 395095005915 Hemerythrin-like domain; Region: Hr-like; cd12108 395095005916 Fe binding site [ion binding]; other site 395095005917 Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cd00227 395095005918 P-loop motif; other site 395095005919 ATP binding site [chemical binding]; other site 395095005920 Chloramphenicol (Cm) binding site [chemical binding]; other site 395095005921 catalytic residue [active] 395095005922 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 395095005923 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 395095005924 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 395095005925 anti sigma factor interaction site; other site 395095005926 regulatory phosphorylation site [posttranslational modification]; other site 395095005927 hypothetical protein; Provisional; Region: PRK02237 395095005928 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 395095005929 Transcriptional regulators [Transcription]; Region: MarR; COG1846 395095005930 putative DNA binding site [nucleotide binding]; other site 395095005931 putative Zn2+ binding site [ion binding]; other site 395095005932 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 395095005933 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 395095005934 putative metal binding site [ion binding]; other site 395095005935 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 395095005936 dimerization interface [polypeptide binding]; other site 395095005937 putative DNA binding site [nucleotide binding]; other site 395095005938 putative Zn2+ binding site [ion binding]; other site 395095005939 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 395095005940 arsenical-resistance protein; Region: acr3; TIGR00832 395095005941 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 395095005942 Low molecular weight phosphatase family; Region: LMWPc; cd00115 395095005943 active site 395095005944 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 395095005945 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 395095005946 active site 395095005947 DNA binding site [nucleotide binding] 395095005948 Int/Topo IB signature motif; other site 395095005949 Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653 395095005950 Phage capsid family; Region: Phage_capsid; pfam05065 395095005951 Phage head maturation protease [General function prediction only]; Region: COG3740 395095005952 Protein of unknown function (DUF3631); Region: DUF3631; pfam12307 395095005953 Protein of unknown function (DUF2742); Region: DUF2742; pfam10888 395095005954 DNA binding domain, excisionase family; Region: excise; TIGR01764 395095005955 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 395095005956 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 395095005957 active site 395095005958 catalytic residues [active] 395095005959 DNA binding site [nucleotide binding] 395095005960 Int/Topo IB signature motif; other site 395095005961 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 395095005962 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 395095005963 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 395095005964 Coenzyme A binding pocket [chemical binding]; other site 395095005965 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 395095005966 hypothetical protein; Provisional; Region: PRK14059 395095005967 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 395095005968 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 395095005969 SelR domain; Region: SelR; pfam01641 395095005970 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 395095005971 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 395095005972 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 395095005973 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 395095005974 catalytic site [active] 395095005975 putative active site [active] 395095005976 putative substrate binding site [chemical binding]; other site 395095005977 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 395095005978 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 395095005979 TPP-binding site; other site 395095005980 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 395095005981 PYR/PP interface [polypeptide binding]; other site 395095005982 dimer interface [polypeptide binding]; other site 395095005983 TPP binding site [chemical binding]; other site 395095005984 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 395095005985 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 395095005986 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 395095005987 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 395095005988 transmembrane helices; other site 395095005989 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 395095005990 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 395095005991 transmembrane helices; other site 395095005992 TRAM domain; Region: TRAM; cl01282 395095005993 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 395095005994 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 395095005995 TrkA-N domain; Region: TrkA_N; pfam02254 395095005996 TrkA-C domain; Region: TrkA_C; pfam02080 395095005997 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 395095005998 TrkA-N domain; Region: TrkA_N; pfam02254 395095005999 TrkA-C domain; Region: TrkA_C; pfam02080 395095006000 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 395095006001 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 395095006002 generic binding surface II; other site 395095006003 ssDNA binding site; other site 395095006004 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 395095006005 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 395095006006 trimer interface [polypeptide binding]; other site 395095006007 active site 395095006008 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 395095006009 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 395095006010 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 395095006011 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 395095006012 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 395095006013 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 395095006014 homotrimer interaction site [polypeptide binding]; other site 395095006015 putative active site [active] 395095006016 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 395095006017 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 395095006018 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 395095006019 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 395095006020 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 395095006021 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 395095006022 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 395095006023 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 395095006024 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 395095006025 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 395095006026 PAC2 family; Region: PAC2; pfam09754 395095006027 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 395095006028 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 395095006029 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 395095006030 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 395095006031 heme-binding site [chemical binding]; other site 395095006032 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 395095006033 ATP cone domain; Region: ATP-cone; pfam03477 395095006034 LysM domain; Region: LysM; pfam01476 395095006035 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 395095006036 LGFP repeat; Region: LGFP; pfam08310 395095006037 LGFP repeat; Region: LGFP; pfam08310 395095006038 LGFP repeat; Region: LGFP; pfam08310 395095006039 LGFP repeat; Region: LGFP; pfam08310 395095006040 LGFP repeat; Region: LGFP; pfam08310 395095006041 Integral membrane protein TerC family; Region: TerC; cl10468 395095006042 GTPases [General function prediction only]; Region: HflX; COG2262 395095006043 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 395095006044 HflX GTPase family; Region: HflX; cd01878 395095006045 G1 box; other site 395095006046 GTP/Mg2+ binding site [chemical binding]; other site 395095006047 Switch I region; other site 395095006048 G2 box; other site 395095006049 G3 box; other site 395095006050 Switch II region; other site 395095006051 G4 box; other site 395095006052 G5 box; other site 395095006053 diaminopimelate epimerase; Region: DapF; TIGR00652 395095006054 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 395095006055 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 395095006056 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 395095006057 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 395095006058 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 395095006059 active site 395095006060 metal binding site [ion binding]; metal-binding site 395095006061 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 395095006062 FeS/SAM binding site; other site 395095006063 Uncharacterized protein conserved in bacteria [General function prediction only]; Region: OraA; COG2137 395095006064 DNA recombination protein RecA; Reviewed; Region: recA; PRK09519 395095006065 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 395095006066 hexamer interface [polypeptide binding]; other site 395095006067 Walker A motif; other site 395095006068 ATP binding site [chemical binding]; other site 395095006069 Walker B motif; other site 395095006070 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 395095006071 protein-splicing catalytic site; other site 395095006072 thioester formation/cholesterol transfer; other site 395095006073 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 395095006074 recA bacterial DNA recombination protein; Region: RecA; cl17211 395095006075 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 395095006076 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 395095006077 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 395095006078 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 395095006079 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 395095006080 Coenzyme A binding pocket [chemical binding]; other site 395095006081 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 395095006082 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 395095006083 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 395095006084 Uncharacterized conserved protein [Function unknown]; Region: COG1359 395095006085 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 395095006086 classical (c) SDRs; Region: SDR_c; cd05233 395095006087 NAD(P) binding site [chemical binding]; other site 395095006088 active site 395095006089 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 395095006090 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 395095006091 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 395095006092 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 395095006093 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 395095006094 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 395095006095 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 395095006096 dimer interface [polypeptide binding]; other site 395095006097 active site 395095006098 catalytic residue [active] 395095006099 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 395095006100 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 395095006101 HsdM N-terminal domain; Region: HsdM_N; pfam12161 395095006102 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 395095006103 Methyltransferase domain; Region: Methyltransf_26; pfam13659 395095006104 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 395095006105 putative active site [active] 395095006106 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 395095006107 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 395095006108 putative active site [active] 395095006109 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 395095006110 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 395095006111 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 395095006112 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 395095006113 thymidylate synthase; Reviewed; Region: thyA; PRK01827 395095006114 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 395095006115 dimerization interface [polypeptide binding]; other site 395095006116 active site 395095006117 Dienelactone hydrolase family; Region: DLH; pfam01738 395095006118 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 395095006119 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 395095006120 classical (c) SDRs; Region: SDR_c; cd05233 395095006121 NAD(P) binding site [chemical binding]; other site 395095006122 active site 395095006123 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 395095006124 PPE family; Region: PPE; pfam00823 395095006125 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 395095006126 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 395095006127 PPE family; Region: PPE; pfam00823 395095006128 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 395095006129 dihydrodipicolinate reductase; Provisional; Region: PRK00048 395095006130 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 395095006131 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 395095006132 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 395095006133 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 395095006134 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 395095006135 Coenzyme A binding pocket [chemical binding]; other site 395095006136 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 395095006137 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 395095006138 FMN-binding pocket [chemical binding]; other site 395095006139 flavin binding motif; other site 395095006140 phosphate binding motif [ion binding]; other site 395095006141 beta-alpha-beta structure motif; other site 395095006142 NAD binding pocket [chemical binding]; other site 395095006143 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 395095006144 catalytic loop [active] 395095006145 iron binding site [ion binding]; other site 395095006146 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 395095006147 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 395095006148 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 395095006149 hydrophobic ligand binding site; other site 395095006150 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 395095006151 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 395095006152 putative DNA binding site [nucleotide binding]; other site 395095006153 putative Zn2+ binding site [ion binding]; other site 395095006154 AsnC family; Region: AsnC_trans_reg; pfam01037 395095006155 alanine dehydrogenase; Region: alaDH; TIGR00518 395095006156 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 395095006157 hexamer interface [polypeptide binding]; other site 395095006158 ligand binding site [chemical binding]; other site 395095006159 putative active site [active] 395095006160 NAD(P) binding site [chemical binding]; other site 395095006161 Nitronate monooxygenase; Region: NMO; pfam03060 395095006162 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 395095006163 FMN binding site [chemical binding]; other site 395095006164 substrate binding site [chemical binding]; other site 395095006165 putative catalytic residue [active] 395095006166 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 395095006167 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 395095006168 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 395095006169 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 395095006170 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 395095006171 oligomer interface [polypeptide binding]; other site 395095006172 RNA binding site [nucleotide binding]; other site 395095006173 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 395095006174 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 395095006175 RNase E interface [polypeptide binding]; other site 395095006176 trimer interface [polypeptide binding]; other site 395095006177 active site 395095006178 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 395095006179 putative nucleic acid binding region [nucleotide binding]; other site 395095006180 G-X-X-G motif; other site 395095006181 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 395095006182 RNA binding site [nucleotide binding]; other site 395095006183 domain interface; other site 395095006184 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 395095006185 16S/18S rRNA binding site [nucleotide binding]; other site 395095006186 S13e-L30e interaction site [polypeptide binding]; other site 395095006187 25S rRNA binding site [nucleotide binding]; other site 395095006188 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 395095006189 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 395095006190 active site 395095006191 Riboflavin kinase; Region: Flavokinase; pfam01687 395095006192 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 395095006193 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 395095006194 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 395095006195 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 395095006196 putative DNA binding site [nucleotide binding]; other site 395095006197 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 395095006198 FeoA domain; Region: FeoA; pfam04023 395095006199 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 395095006200 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 395095006201 active site 395095006202 lipid-transfer protein; Provisional; Region: PRK08256 395095006203 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 395095006204 active site 395095006205 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 395095006206 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 395095006207 Probable transposase; Region: OrfB_IS605; pfam01385 395095006208 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 395095006209 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 395095006210 catalytic residues [active] 395095006211 catalytic nucleophile [active] 395095006212 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 395095006213 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 395095006214 RNA binding site [nucleotide binding]; other site 395095006215 active site 395095006216 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 395095006217 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 395095006218 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 395095006219 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 395095006220 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 395095006221 active site 395095006222 metal binding site [ion binding]; metal-binding site 395095006223 Uncharacterized conserved protein [Function unknown]; Region: COG4717 395095006224 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 395095006225 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 395095006226 Predicted acyl esterases [General function prediction only]; Region: COG2936 395095006227 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 395095006228 Uncharacterized conserved protein [Function unknown]; Region: COG5586 395095006229 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 395095006230 Integrase core domain; Region: rve; pfam00665 395095006231 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 395095006232 Transposase; Region: DDE_Tnp_ISL3; pfam01610 395095006233 Helix-turn-helix domain; Region: HTH_28; pfam13518 395095006234 Winged helix-turn helix; Region: HTH_29; pfam13551 395095006235 Integrase core domain; Region: rve; pfam00665 395095006236 Integrase core domain; Region: rve_3; pfam13683 395095006237 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 395095006238 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 395095006239 Transposase; Region: HTH_Tnp_1; cl17663 395095006240 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 395095006241 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09636 395095006242 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cd09699 395095006243 CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cd09662 395095006244 CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cd09663 395095006245 CRISPR/Cas system-associated RAMP superfamily protein Csm3; Region: Csm3_III-A; cd09684 395095006246 CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cd09647 395095006247 Predicted CRISPR-associated polymerase [Defense mechanisms]; Region: COG1353 395095006248 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 395095006249 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 395095006250 Domain of unknown function (DUF1802); Region: DUF1802; cl01755 395095006251 enoyl-CoA hydratase; Provisional; Region: PRK06190 395095006252 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 395095006253 substrate binding site [chemical binding]; other site 395095006254 oxyanion hole (OAH) forming residues; other site 395095006255 trimer interface [polypeptide binding]; other site 395095006256 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 395095006257 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 395095006258 Walker A/P-loop; other site 395095006259 ATP binding site [chemical binding]; other site 395095006260 Q-loop/lid; other site 395095006261 ABC transporter signature motif; other site 395095006262 Walker B; other site 395095006263 D-loop; other site 395095006264 H-loop/switch region; other site 395095006265 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 395095006266 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 395095006267 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 395095006268 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395095006269 dimer interface [polypeptide binding]; other site 395095006270 conserved gate region; other site 395095006271 putative PBP binding loops; other site 395095006272 ABC-ATPase subunit interface; other site 395095006273 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 395095006274 DHH family; Region: DHH; pfam01368 395095006275 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 395095006276 Predicted nucleic-acid-binding protein implicated in transcription termination [Transcription]; Region: COG2740 395095006277 putative RNA binding cleft [nucleotide binding]; other site 395095006278 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 395095006279 NusA N-terminal domain; Region: NusA_N; pfam08529 395095006280 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 395095006281 RNA binding site [nucleotide binding]; other site 395095006282 homodimer interface [polypeptide binding]; other site 395095006283 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 395095006284 G-X-X-G motif; other site 395095006285 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 395095006286 G-X-X-G motif; other site 395095006287 ribosome maturation protein RimP; Reviewed; Region: PRK00092 395095006288 Sm and related proteins; Region: Sm_like; cl00259 395095006289 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 395095006290 putative oligomer interface [polypeptide binding]; other site 395095006291 putative RNA binding site [nucleotide binding]; other site 395095006292 Mitochondrial ATP synthase g subunit; Region: ATP-synt_G; pfam04718 395095006293 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 395095006294 dinuclear metal binding motif [ion binding]; other site 395095006295 prolyl-tRNA synthetase; Provisional; Region: PRK09194 395095006296 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 395095006297 dimer interface [polypeptide binding]; other site 395095006298 motif 1; other site 395095006299 active site 395095006300 motif 2; other site 395095006301 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 395095006302 putative deacylase active site [active] 395095006303 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 395095006304 active site 395095006305 motif 3; other site 395095006306 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 395095006307 anticodon binding site; other site 395095006308 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 395095006309 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 395095006310 putative substrate translocation pore; other site 395095006311 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 395095006312 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 395095006313 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 395095006314 catalytic triad [active] 395095006315 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 395095006316 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 395095006317 homodimer interface [polypeptide binding]; other site 395095006318 Walker A motif; other site 395095006319 ATP binding site [chemical binding]; other site 395095006320 hydroxycobalamin binding site [chemical binding]; other site 395095006321 Walker B motif; other site 395095006322 Predicted acyltransferase [General function prediction only]; Region: ElaA; COG2153 395095006323 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 395095006324 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 395095006325 mycothione reductase; Reviewed; Region: PRK07846 395095006326 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 395095006327 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 395095006328 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 395095006329 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 395095006330 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 395095006331 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 395095006332 NAD(P) binding site [chemical binding]; other site 395095006333 catalytic residues [active] 395095006334 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 395095006335 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 395095006336 catalytic triad [active] 395095006337 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 395095006338 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 395095006339 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 395095006340 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 395095006341 active site 395095006342 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 395095006343 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 395095006344 putative active site [active] 395095006345 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 395095006346 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 395095006347 Predicted acetyltransferase [General function prediction only]; Region: COG3393 395095006348 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 395095006349 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 395095006350 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 395095006351 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 395095006352 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 395095006353 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 395095006354 active site 395095006355 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 395095006356 protein binding site [polypeptide binding]; other site 395095006357 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 395095006358 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 395095006359 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 395095006360 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 395095006361 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 395095006362 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 395095006363 catalytic residues [active] 395095006364 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 395095006365 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 395095006366 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 395095006367 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 395095006368 catalytic residues [active] 395095006369 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 395095006370 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 395095006371 FeS/SAM binding site; other site 395095006372 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 395095006373 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 395095006374 ribosome recycling factor; Reviewed; Region: frr; PRK00083 395095006375 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 395095006376 hinge region; other site 395095006377 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 395095006378 putative nucleotide binding site [chemical binding]; other site 395095006379 uridine monophosphate binding site [chemical binding]; other site 395095006380 homohexameric interface [polypeptide binding]; other site 395095006381 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 395095006382 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 395095006383 DNA binding site [nucleotide binding] 395095006384 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 395095006385 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 395095006386 catalytic residues [active] 395095006387 catalytic nucleophile [active] 395095006388 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 395095006389 MarR family; Region: MarR; pfam01047 395095006390 amidase; Provisional; Region: PRK07869 395095006391 Amidase; Region: Amidase; pfam01425 395095006392 elongation factor Ts; Provisional; Region: tsf; PRK09377 395095006393 UBA/TS-N domain; Region: UBA; pfam00627 395095006394 Elongation factor TS; Region: EF_TS; pfam00889 395095006395 Elongation factor TS; Region: EF_TS; pfam00889 395095006396 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 395095006397 rRNA interaction site [nucleotide binding]; other site 395095006398 S8 interaction site; other site 395095006399 putative laminin-1 binding site; other site 395095006400 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 395095006401 Peptidase family M23; Region: Peptidase_M23; pfam01551 395095006402 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 395095006403 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 395095006404 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 395095006405 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 395095006406 active site 395095006407 DNA binding site [nucleotide binding] 395095006408 Int/Topo IB signature motif; other site 395095006409 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 395095006410 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 395095006411 FAD binding pocket [chemical binding]; other site 395095006412 FAD binding motif [chemical binding]; other site 395095006413 phosphate binding motif [ion binding]; other site 395095006414 NAD binding pocket [chemical binding]; other site 395095006415 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 395095006416 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 395095006417 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395095006418 Walker A motif; other site 395095006419 ATP binding site [chemical binding]; other site 395095006420 Walker B motif; other site 395095006421 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 395095006422 hypothetical protein; Reviewed; Region: PRK12497 395095006423 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 395095006424 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 395095006425 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 395095006426 putative molybdopterin cofactor binding site [chemical binding]; other site 395095006427 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 395095006428 putative molybdopterin cofactor binding site; other site 395095006429 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 395095006430 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 395095006431 RNA/DNA hybrid binding site [nucleotide binding]; other site 395095006432 active site 395095006433 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 395095006434 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 395095006435 Catalytic site [active] 395095006436 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 395095006437 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 395095006438 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 395095006439 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 395095006440 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 395095006441 RimM N-terminal domain; Region: RimM; pfam01782 395095006442 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 395095006443 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 395095006444 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 395095006445 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 395095006446 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 395095006447 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 395095006448 active site 395095006449 putative substrate binding pocket [chemical binding]; other site 395095006450 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 395095006451 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 395095006452 Catalytic domain of Protein Kinases; Region: PKc; cd00180 395095006453 active site 395095006454 ATP binding site [chemical binding]; other site 395095006455 substrate binding site [chemical binding]; other site 395095006456 activation loop (A-loop); other site 395095006457 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 395095006458 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 395095006459 active site 395095006460 signal recognition particle protein; Provisional; Region: PRK10867 395095006461 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 395095006462 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 395095006463 P loop; other site 395095006464 GTP binding site [chemical binding]; other site 395095006465 Signal peptide binding domain; Region: SRP_SPB; pfam02978 395095006466 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 395095006467 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 395095006468 ATP binding site [chemical binding]; other site 395095006469 putative Mg++ binding site [ion binding]; other site 395095006470 PII uridylyl-transferase; Provisional; Region: PRK03381 395095006471 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 395095006472 metal binding triad; other site 395095006473 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 395095006474 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 395095006475 Zn2+ binding site [ion binding]; other site 395095006476 Mg2+ binding site [ion binding]; other site 395095006477 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 395095006478 Nitrogen regulatory protein P-II; Region: P-II; smart00938 395095006479 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 395095006480 acylphosphatase; Provisional; Region: PRK14422 395095006481 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 395095006482 ribonuclease III; Reviewed; Region: rnc; PRK00102 395095006483 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 395095006484 dimerization interface [polypeptide binding]; other site 395095006485 active site 395095006486 metal binding site [ion binding]; metal-binding site 395095006487 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 395095006488 dsRNA binding site [nucleotide binding]; other site 395095006489 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 395095006490 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 395095006491 acyl-CoA synthetase; Validated; Region: PRK05850 395095006492 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 395095006493 acyl-activating enzyme (AAE) consensus motif; other site 395095006494 active site 395095006495 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 395095006496 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 395095006497 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 395095006498 active site 395095006499 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 395095006500 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 395095006501 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 395095006502 NADP binding site [chemical binding]; other site 395095006503 KR domain; Region: KR; pfam08659 395095006504 active site 395095006505 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 395095006506 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 395095006507 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 395095006508 active site 395095006509 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 395095006510 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 395095006511 Condensation domain; Region: Condensation; pfam00668 395095006512 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 395095006513 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 395095006514 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 395095006515 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 395095006516 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 395095006517 acyltransferase PapA5; Provisional; Region: PRK09294 395095006518 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 395095006519 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 395095006520 active site 395095006521 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 395095006522 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 395095006523 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395095006524 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 395095006525 Enoylreductase; Region: PKS_ER; smart00829 395095006526 NAD(P) binding site [chemical binding]; other site 395095006527 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 395095006528 KR domain; Region: KR; pfam08659 395095006529 putative NADP binding site [chemical binding]; other site 395095006530 active site 395095006531 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 395095006532 acyl-CoA synthetase; Validated; Region: PRK05850 395095006533 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 395095006534 acyl-activating enzyme (AAE) consensus motif; other site 395095006535 active site 395095006536 MMPL family; Region: MMPL; pfam03176 395095006537 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 395095006538 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 395095006539 Integrase core domain; Region: rve; pfam00665 395095006540 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 395095006541 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395095006542 ATP binding site [chemical binding]; other site 395095006543 Walker A motif; other site 395095006544 Walker B motif; other site 395095006545 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 395095006546 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 395095006547 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 395095006548 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 395095006549 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395095006550 Enoylreductase; Region: PKS_ER; smart00829 395095006551 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 395095006552 NAD(P) binding site [chemical binding]; other site 395095006553 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 395095006554 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 395095006555 putative NADP binding site [chemical binding]; other site 395095006556 active site 395095006557 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 395095006558 Erythronolide synthase docking; Region: Docking; pfam08990 395095006559 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 395095006560 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 395095006561 active site 395095006562 acyl-CoA synthetase; Validated; Region: PRK06060 395095006563 Benzoate CoA ligase (BCL) and similar adenylate forming enzymes; Region: BCL_like; cd05919 395095006564 dimer interface [polypeptide binding]; other site 395095006565 acyl-activating enzyme (AAE) consensus motif; other site 395095006566 putative active site [active] 395095006567 putative AMP binding site [chemical binding]; other site 395095006568 putative CoA binding site [chemical binding]; other site 395095006569 chemical substrate binding site [chemical binding]; other site 395095006570 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 395095006571 4-hydroxybenzoate synthetase (chorismate lyase) [Coenzyme metabolism]; Region: UbiC; COG3161 395095006572 acyl-CoA synthetase; Validated; Region: PRK05850 395095006573 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 395095006574 acyl-activating enzyme (AAE) consensus motif; other site 395095006575 active site 395095006576 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 395095006577 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 395095006578 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395095006579 S-adenosylmethionine binding site [chemical binding]; other site 395095006580 Uncharacterized conserved protein [Function unknown]; Region: COG3268 395095006581 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 395095006582 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 395095006583 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 395095006584 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 395095006585 active site 395095006586 TDP-binding site; other site 395095006587 acceptor substrate-binding pocket; other site 395095006588 Cephalosporin hydroxylase [Defense mechanisms]; Region: CmcI; COG3510 395095006589 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 395095006590 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 395095006591 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 395095006592 active site 395095006593 TDP-binding site; other site 395095006594 acceptor substrate-binding pocket; other site 395095006595 Predicted permease; Region: DUF318; pfam03773 395095006596 formyltetrahydrofolate deformylase; Region: PurU; TIGR00655 395095006597 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 395095006598 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 395095006599 putative active site [active] 395095006600 putative substrate binding site [chemical binding]; other site 395095006601 putative cosubstrate binding site; other site 395095006602 catalytic site [active] 395095006603 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 395095006604 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 395095006605 active site 395095006606 (T/H)XGH motif; other site 395095006607 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 395095006608 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395095006609 S-adenosylmethionine binding site [chemical binding]; other site 395095006610 pyruvate carboxylase; Reviewed; Region: PRK12999 395095006611 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 395095006612 ATP-grasp domain; Region: ATP-grasp_4; cl17255 395095006613 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 395095006614 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 395095006615 active site 395095006616 catalytic residues [active] 395095006617 metal binding site [ion binding]; metal-binding site 395095006618 homodimer binding site [polypeptide binding]; other site 395095006619 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 395095006620 carboxyltransferase (CT) interaction site; other site 395095006621 biotinylation site [posttranslational modification]; other site 395095006622 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 395095006623 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 395095006624 substrate binding pocket [chemical binding]; other site 395095006625 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 395095006626 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 395095006627 active site 395095006628 catalytic tetrad [active] 395095006629 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 395095006630 RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200 395095006631 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 395095006632 generic binding surface II; other site 395095006633 ssDNA binding site; other site 395095006634 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 395095006635 ATP binding site [chemical binding]; other site 395095006636 putative Mg++ binding site [ion binding]; other site 395095006637 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 395095006638 nucleotide binding region [chemical binding]; other site 395095006639 ATP-binding site [chemical binding]; other site 395095006640 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 395095006641 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 395095006642 ligand binding site [chemical binding]; other site 395095006643 active site 395095006644 UGI interface [polypeptide binding]; other site 395095006645 catalytic site [active] 395095006646 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 395095006647 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 395095006648 Probable transposase; Region: OrfB_IS605; pfam01385 395095006649 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 395095006650 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 395095006651 catalytic residues [active] 395095006652 catalytic nucleophile [active] 395095006653 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 395095006654 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 395095006655 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 395095006656 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 395095006657 active site 395095006658 Ap6A binding site [chemical binding]; other site 395095006659 nudix motif; other site 395095006660 metal binding site [ion binding]; metal-binding site 395095006661 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 395095006662 catalytic core [active] 395095006663 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 395095006664 IHF - DNA interface [nucleotide binding]; other site 395095006665 IHF dimer interface [polypeptide binding]; other site 395095006666 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 395095006667 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 395095006668 substrate binding site [chemical binding]; other site 395095006669 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 395095006670 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 395095006671 substrate binding site [chemical binding]; other site 395095006672 ligand binding site [chemical binding]; other site 395095006673 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 395095006674 Transcriptional regulator [Transcription]; Region: IclR; COG1414 395095006675 Bacterial transcriptional regulator; Region: IclR; pfam01614 395095006676 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395095006677 S-adenosylmethionine binding site [chemical binding]; other site 395095006678 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 395095006679 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 395095006680 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 395095006681 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 395095006682 active site 395095006683 HIGH motif; other site 395095006684 nucleotide binding site [chemical binding]; other site 395095006685 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 395095006686 active site 395095006687 KMSKS motif; other site 395095006688 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 395095006689 Major Facilitator Superfamily; Region: MFS_1; pfam07690 395095006690 putative substrate translocation pore; other site 395095006691 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 395095006692 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 395095006693 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 395095006694 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 395095006695 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 395095006696 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 395095006697 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 395095006698 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 395095006699 putative valine binding site [chemical binding]; other site 395095006700 dimer interface [polypeptide binding]; other site 395095006701 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 395095006702 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 395095006703 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 395095006704 PYR/PP interface [polypeptide binding]; other site 395095006705 dimer interface [polypeptide binding]; other site 395095006706 TPP binding site [chemical binding]; other site 395095006707 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 395095006708 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 395095006709 TPP-binding site [chemical binding]; other site 395095006710 dimer interface [polypeptide binding]; other site 395095006711 Predicted membrane protein [Function unknown]; Region: COG2259 395095006712 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 395095006713 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 395095006714 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 395095006715 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 395095006716 GatB domain; Region: GatB_Yqey; smart00845 395095006717 6-phosphofructokinase; Provisional; Region: PRK03202 395095006718 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 395095006719 active site 395095006720 ADP/pyrophosphate binding site [chemical binding]; other site 395095006721 dimerization interface [polypeptide binding]; other site 395095006722 allosteric effector site; other site 395095006723 fructose-1,6-bisphosphate binding site; other site 395095006724 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 395095006725 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 395095006726 aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, C subunit; Region: gatC; TIGR00135 395095006727 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 395095006728 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 395095006729 nucleotide binding pocket [chemical binding]; other site 395095006730 K-X-D-G motif; other site 395095006731 catalytic site [active] 395095006732 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 395095006733 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 395095006734 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 395095006735 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 395095006736 Dimer interface [polypeptide binding]; other site 395095006737 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 395095006738 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 395095006739 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 395095006740 Ligand Binding Site [chemical binding]; other site 395095006741 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 395095006742 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 395095006743 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 395095006744 catalytic residue [active] 395095006745 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 395095006746 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 395095006747 putative acyl-acceptor binding pocket; other site 395095006748 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 395095006749 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 395095006750 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 395095006751 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 395095006752 Ligand binding site [chemical binding]; other site 395095006753 Electron transfer flavoprotein domain; Region: ETF; pfam01012 395095006754 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395095006755 S-adenosylmethionine binding site [chemical binding]; other site 395095006756 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 395095006757 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 395095006758 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 395095006759 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 395095006760 FOG: WD40-like repeat [Function unknown]; Region: COG1520 395095006761 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 395095006762 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395095006763 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395095006764 S-adenosylmethionine binding site [chemical binding]; other site 395095006765 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 395095006766 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 395095006767 Walker A/P-loop; other site 395095006768 ATP binding site [chemical binding]; other site 395095006769 Q-loop/lid; other site 395095006770 ABC transporter signature motif; other site 395095006771 Walker B; other site 395095006772 D-loop; other site 395095006773 H-loop/switch region; other site 395095006774 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 395095006775 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 395095006776 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 395095006777 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 395095006778 motif II; other site 395095006779 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 395095006780 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 395095006781 D-pathway; other site 395095006782 Putative ubiquinol binding site [chemical binding]; other site 395095006783 Low-spin heme (heme b) binding site [chemical binding]; other site 395095006784 Putative water exit pathway; other site 395095006785 Binuclear center (heme o3/CuB) [ion binding]; other site 395095006786 K-pathway; other site 395095006787 Putative proton exit pathway; other site 395095006788 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 395095006789 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 395095006790 siderophore binding site; other site 395095006791 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 395095006792 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 395095006793 putative NAD(P) binding site [chemical binding]; other site 395095006794 putative substrate binding site [chemical binding]; other site 395095006795 catalytic Zn binding site [ion binding]; other site 395095006796 structural Zn binding site [ion binding]; other site 395095006797 dimer interface [polypeptide binding]; other site 395095006798 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 395095006799 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 395095006800 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 395095006801 dimer interface [polypeptide binding]; other site 395095006802 putative radical transfer pathway; other site 395095006803 diiron center [ion binding]; other site 395095006804 tyrosyl radical; other site 395095006805 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 395095006806 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 395095006807 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 395095006808 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 395095006809 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 395095006810 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 395095006811 catalytic residues [active] 395095006812 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 395095006813 Predicted flavoprotein [General function prediction only]; Region: COG0431 395095006814 DNA polymerase IV; Validated; Region: PRK03352 395095006815 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 395095006816 active site 395095006817 DNA binding site [nucleotide binding] 395095006818 short chain dehydrogenase; Provisional; Region: PRK07832 395095006819 classical (c) SDRs; Region: SDR_c; cd05233 395095006820 NAD(P) binding site [chemical binding]; other site 395095006821 active site 395095006822 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 395095006823 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 395095006824 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 395095006825 Cytochrome P450; Region: p450; cl12078 395095006826 Transcriptional regulators [Transcription]; Region: FadR; COG2186 395095006827 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 395095006828 DNA-binding site [nucleotide binding]; DNA binding site 395095006829 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 395095006830 Transcriptional regulators [Transcription]; Region: FadR; COG2186 395095006831 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 395095006832 DNA-binding site [nucleotide binding]; DNA binding site 395095006833 FCD domain; Region: FCD; pfam07729 395095006834 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 395095006835 Carbon starvation protein CstA; Region: CstA; pfam02554 395095006836 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 395095006837 Predicted membrane protein [Function unknown]; Region: COG2259 395095006838 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 395095006839 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 395095006840 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 395095006841 Protein of unknown function (DUF732); Region: DUF732; pfam05305 395095006842 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 395095006843 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 395095006844 active site 395095006845 substrate binding site [chemical binding]; other site 395095006846 metal binding site [ion binding]; metal-binding site 395095006847 camphor resistance protein CrcB; Provisional; Region: PRK14216 395095006848 camphor resistance protein CrcB; Provisional; Region: PRK14228 395095006849 Uncharacterized conserved protein [Function unknown]; Region: COG3189 395095006850 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 395095006851 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 395095006852 putative hydrophobic ligand binding site [chemical binding]; other site 395095006853 protein interface [polypeptide binding]; other site 395095006854 gate; other site 395095006855 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 395095006856 Sulfatase; Region: Sulfatase; pfam00884 395095006857 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 395095006858 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 395095006859 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 395095006860 Catalytic domain of Protein Kinases; Region: PKc; cd00180 395095006861 active site 395095006862 ATP binding site [chemical binding]; other site 395095006863 substrate binding site [chemical binding]; other site 395095006864 activation loop (A-loop); other site 395095006865 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 395095006866 AAA ATPase domain; Region: AAA_16; pfam13191 395095006867 Nucleotidyl transferase of unknown function (DUF2204); Region: DUF2204; pfam09970 395095006868 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 395095006869 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 395095006870 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 395095006871 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 395095006872 short chain dehydrogenase; Provisional; Region: PRK07832 395095006873 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395095006874 NAD(P) binding site [chemical binding]; other site 395095006875 active site 395095006876 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 395095006877 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 395095006878 NAD binding site [chemical binding]; other site 395095006879 catalytic Zn binding site [ion binding]; other site 395095006880 substrate binding site [chemical binding]; other site 395095006881 structural Zn binding site [ion binding]; other site 395095006882 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 395095006883 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 395095006884 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 395095006885 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 395095006886 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 395095006887 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 395095006888 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 395095006889 acyl-activating enzyme (AAE) consensus motif; other site 395095006890 AMP binding site [chemical binding]; other site 395095006891 active site 395095006892 CoA binding site [chemical binding]; other site 395095006893 SPFH domain / Band 7 family; Region: Band_7; pfam01145 395095006894 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 395095006895 Patatin-like phospholipase; Region: Patatin; pfam01734 395095006896 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 395095006897 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 395095006898 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 395095006899 active site 395095006900 Predicted transcriptional regulators [Transcription]; Region: COG1733 395095006901 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 395095006902 dimerization interface [polypeptide binding]; other site 395095006903 putative DNA binding site [nucleotide binding]; other site 395095006904 putative Zn2+ binding site [ion binding]; other site 395095006905 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 395095006906 PemK-like protein; Region: PemK; pfam02452 395095006907 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 395095006908 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 395095006909 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 395095006910 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 395095006911 SmpB-tmRNA interface; other site 395095006912 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 395095006913 FtsX-like permease family; Region: FtsX; pfam02687 395095006914 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 395095006915 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 395095006916 Walker A/P-loop; other site 395095006917 ATP binding site [chemical binding]; other site 395095006918 Q-loop/lid; other site 395095006919 ABC transporter signature motif; other site 395095006920 Walker B; other site 395095006921 D-loop; other site 395095006922 H-loop/switch region; other site 395095006923 peptide chain release factor 2; Validated; Region: prfB; PRK00578 395095006924 This domain is found in peptide chain release factors; Region: PCRF; smart00937 395095006925 RF-1 domain; Region: RF-1; pfam00472 395095006926 ferredoxin-NADP+ reductase; Region: PLN02852 395095006927 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 395095006928 FAD binding domain; Region: FAD_binding_4; pfam01565 395095006929 Molybdenum cofactor biosynthesis enzyme [Coenzyme metabolism]; Region: MoaA; COG2896 395095006930 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 395095006931 FeS/SAM binding site; other site 395095006932 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 395095006933 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 395095006934 aromatic arch; other site 395095006935 DCoH dimer interaction site [polypeptide binding]; other site 395095006936 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 395095006937 DCoH tetramer interaction site [polypeptide binding]; other site 395095006938 substrate binding site [chemical binding]; other site 395095006939 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 395095006940 trimer interface [polypeptide binding]; other site 395095006941 dimer interface [polypeptide binding]; other site 395095006942 putative active site [active] 395095006943 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 395095006944 MoaE interaction surface [polypeptide binding]; other site 395095006945 MoeB interaction surface [polypeptide binding]; other site 395095006946 thiocarboxylated glycine; other site 395095006947 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 395095006948 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 395095006949 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 395095006950 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 395095006951 ATP binding site [chemical binding]; other site 395095006952 substrate interface [chemical binding]; other site 395095006953 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 395095006954 active site residue [active] 395095006955 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 395095006956 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 395095006957 active site residue [active] 395095006958 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 395095006959 active site residue [active] 395095006960 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 395095006961 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 395095006962 MoaE homodimer interface [polypeptide binding]; other site 395095006963 MoaD interaction [polypeptide binding]; other site 395095006964 active site residues [active] 395095006965 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395095006966 S-adenosylmethionine binding site [chemical binding]; other site 395095006967 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 395095006968 Cytochrome P450; Region: p450; cl12078 395095006969 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 395095006970 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 395095006971 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 395095006972 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 395095006973 dimer interface [polypeptide binding]; other site 395095006974 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 395095006975 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 395095006976 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 395095006977 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 395095006978 Histidine kinase; Region: HisKA_3; pfam07730 395095006979 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395095006980 ATP binding site [chemical binding]; other site 395095006981 Mg2+ binding site [ion binding]; other site 395095006982 G-X-G motif; other site 395095006983 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 395095006984 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395095006985 active site 395095006986 phosphorylation site [posttranslational modification] 395095006987 intermolecular recognition site; other site 395095006988 dimerization interface [polypeptide binding]; other site 395095006989 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 395095006990 DNA binding residues [nucleotide binding] 395095006991 dimerization interface [polypeptide binding]; other site 395095006992 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 395095006993 Ligand Binding Site [chemical binding]; other site 395095006994 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 395095006995 PPE family; Region: PPE; pfam00823 395095006996 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 395095006997 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 395095006998 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 395095006999 active site 395095007000 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 395095007001 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 395095007002 FeS/SAM binding site; other site 395095007003 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 395095007004 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 395095007005 active site 395095007006 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 395095007007 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 395095007008 active site 395095007009 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 395095007010 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 395095007011 NAD(P) binding site [chemical binding]; other site 395095007012 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395095007013 active site 395095007014 phosphorylation site [posttranslational modification] 395095007015 intermolecular recognition site; other site 395095007016 NADH dehydrogenase subunit A; Validated; Region: PRK07928 395095007017 NADH dehydrogenase subunit B; Validated; Region: PRK06411 395095007018 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 395095007019 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 395095007020 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 395095007021 NADH dehydrogenase subunit D; Validated; Region: PRK06075 395095007022 NADH dehydrogenase subunit E; Validated; Region: PRK07539 395095007023 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 395095007024 putative dimer interface [polypeptide binding]; other site 395095007025 [2Fe-2S] cluster binding site [ion binding]; other site 395095007026 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 395095007027 SLBB domain; Region: SLBB; pfam10531 395095007028 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 395095007029 NADH dehydrogenase subunit G; Validated; Region: PRK07860 395095007030 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 395095007031 catalytic loop [active] 395095007032 iron binding site [ion binding]; other site 395095007033 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 395095007034 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 395095007035 [4Fe-4S] binding site [ion binding]; other site 395095007036 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 395095007037 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 395095007038 4Fe-4S binding domain; Region: Fer4; pfam00037 395095007039 4Fe-4S binding domain; Region: Fer4; pfam00037 395095007040 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 395095007041 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 395095007042 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 395095007043 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 395095007044 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 395095007045 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 395095007046 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 395095007047 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 395095007048 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 395095007049 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 395095007050 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 395095007051 [2Fe-2S] cluster binding site [ion binding]; other site 395095007052 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_1; cd08885 395095007053 putative alpha subunit interface [polypeptide binding]; other site 395095007054 putative active site [active] 395095007055 putative substrate binding site [chemical binding]; other site 395095007056 Fe binding site [ion binding]; other site 395095007057 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 395095007058 Protein of unknown function DUF58; Region: DUF58; pfam01882 395095007059 MoxR-like ATPases [General function prediction only]; Region: COG0714 395095007060 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395095007061 Walker A motif; other site 395095007062 ATP binding site [chemical binding]; other site 395095007063 Walker B motif; other site 395095007064 arginine finger; other site 395095007065 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 395095007066 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 395095007067 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 395095007068 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 395095007069 putative active site [active] 395095007070 putative substrate binding site [chemical binding]; other site 395095007071 ATP binding site [chemical binding]; other site 395095007072 Phosphotransferase enzyme family; Region: APH; pfam01636 395095007073 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 395095007074 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 395095007075 hydroxyglutarate oxidase; Provisional; Region: PRK11728 395095007076 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 395095007077 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 395095007078 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 395095007079 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 395095007080 short chain dehydrogenase; Validated; Region: PRK08264 395095007081 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395095007082 NAD(P) binding site [chemical binding]; other site 395095007083 active site 395095007084 amidase; Provisional; Region: PRK06170 395095007085 Amidase; Region: Amidase; pfam01425 395095007086 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 395095007087 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 395095007088 TAP-like protein; Region: Abhydrolase_4; pfam08386 395095007089 Domain of unknown function (DUF385); Region: DUF385; pfam04075 395095007090 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 395095007091 putative active site [active] 395095007092 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 395095007093 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 395095007094 non-specific DNA binding site [nucleotide binding]; other site 395095007095 salt bridge; other site 395095007096 sequence-specific DNA binding site [nucleotide binding]; other site 395095007097 RES domain; Region: RES; pfam08808 395095007098 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 395095007099 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 395095007100 hypothetical protein; Validated; Region: PRK00068 395095007101 Uncharacterized conserved protein [Function unknown]; Region: COG1615 395095007102 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 395095007103 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 395095007104 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 395095007105 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 395095007106 Uncharacterized conserved protein [Function unknown]; Region: COG5282 395095007107 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 395095007108 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 395095007109 ABC1 family; Region: ABC1; pfam03109 395095007110 Phosphotransferase enzyme family; Region: APH; pfam01636 395095007111 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 395095007112 active site 395095007113 ATP binding site [chemical binding]; other site 395095007114 Transcription factor WhiB; Region: Whib; pfam02467 395095007115 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 395095007116 catalytic residues [active] 395095007117 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 395095007118 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 395095007119 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 395095007120 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 395095007121 putative NADH binding site [chemical binding]; other site 395095007122 putative active site [active] 395095007123 nudix motif; other site 395095007124 putative metal binding site [ion binding]; other site 395095007125 Ion channel; Region: Ion_trans_2; pfam07885 395095007126 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 395095007127 TrkA-N domain; Region: TrkA_N; pfam02254 395095007128 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 395095007129 Part of AAA domain; Region: AAA_19; pfam13245 395095007130 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 395095007131 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 395095007132 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 395095007133 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 395095007134 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 395095007135 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 395095007136 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 395095007137 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 395095007138 active site 395095007139 DNA binding site [nucleotide binding] 395095007140 TIGR02569 family protein; Region: TIGR02569_actnb 395095007141 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 395095007142 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 395095007143 ATP binding site [chemical binding]; other site 395095007144 substrate interface [chemical binding]; other site 395095007145 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 395095007146 active site residue [active] 395095007147 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 395095007148 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 395095007149 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 395095007150 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 395095007151 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like; Region: MiaE_2; pfam13794 395095007152 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 395095007153 DEAD-like helicases superfamily; Region: DEXDc; smart00487 395095007154 ATP binding site [chemical binding]; other site 395095007155 Mg++ binding site [ion binding]; other site 395095007156 motif III; other site 395095007157 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 395095007158 nucleotide binding region [chemical binding]; other site 395095007159 ATP-binding site [chemical binding]; other site 395095007160 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 395095007161 catalytic core [active] 395095007162 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 395095007163 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 395095007164 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 395095007165 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 395095007166 Transcription factor WhiB; Region: Whib; pfam02467 395095007167 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 395095007168 PAS domain S-box; Region: sensory_box; TIGR00229 395095007169 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 395095007170 Histidine kinase; Region: HisKA_2; pfam07568 395095007171 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395095007172 ATP binding site [chemical binding]; other site 395095007173 Mg2+ binding site [ion binding]; other site 395095007174 G-X-G motif; other site 395095007175 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 395095007176 carboxyltransferase (CT) interaction site; other site 395095007177 biotinylation site [posttranslational modification]; other site 395095007178 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 395095007179 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 395095007180 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 395095007181 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 395095007182 DNA binding residues [nucleotide binding] 395095007183 short chain dehydrogenase; Provisional; Region: PRK08278 395095007184 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 395095007185 NAD(P) binding site [chemical binding]; other site 395095007186 homodimer interface [polypeptide binding]; other site 395095007187 active site 395095007188 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 395095007189 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 395095007190 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 395095007191 Coenzyme A binding pocket [chemical binding]; other site 395095007192 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 395095007193 Phosphotransferase enzyme family; Region: APH; pfam01636 395095007194 putative active site [active] 395095007195 putative substrate binding site [chemical binding]; other site 395095007196 ATP binding site [chemical binding]; other site 395095007197 Uncharacterized conserved protein [Function unknown]; Region: COG2135 395095007198 Predicted GTPases [General function prediction only]; Region: COG1162 395095007199 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 395095007200 GTPase/Zn-binding domain interface [polypeptide binding]; other site 395095007201 GTP/Mg2+ binding site [chemical binding]; other site 395095007202 G4 box; other site 395095007203 G5 box; other site 395095007204 G1 box; other site 395095007205 Switch I region; other site 395095007206 G2 box; other site 395095007207 G3 box; other site 395095007208 Switch II region; other site 395095007209 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 395095007210 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 395095007211 putative di-iron ligands [ion binding]; other site 395095007212 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 395095007213 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 395095007214 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 395095007215 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 395095007216 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 395095007217 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 395095007218 TrkA-C domain; Region: TrkA_C; pfam02080 395095007219 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 395095007220 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 395095007221 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 395095007222 putative substrate translocation pore; other site 395095007223 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 395095007224 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 395095007225 ligand binding site [chemical binding]; other site 395095007226 flexible hinge region; other site 395095007227 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 395095007228 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 395095007229 nucleophile elbow; other site 395095007230 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 395095007231 30S subunit binding site; other site 395095007232 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 395095007233 active site 395095007234 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 395095007235 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 395095007236 lipoprotein LpqB; Provisional; Region: PRK13616 395095007237 Sporulation and spore germination; Region: Germane; pfam10646 395095007238 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 395095007239 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 395095007240 dimerization interface [polypeptide binding]; other site 395095007241 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395095007242 dimer interface [polypeptide binding]; other site 395095007243 phosphorylation site [posttranslational modification] 395095007244 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395095007245 ATP binding site [chemical binding]; other site 395095007246 Mg2+ binding site [ion binding]; other site 395095007247 G-X-G motif; other site 395095007248 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 395095007249 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395095007250 active site 395095007251 phosphorylation site [posttranslational modification] 395095007252 intermolecular recognition site; other site 395095007253 dimerization interface [polypeptide binding]; other site 395095007254 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 395095007255 DNA binding site [nucleotide binding] 395095007256 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 395095007257 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 395095007258 TMP-binding site; other site 395095007259 ATP-binding site [chemical binding]; other site 395095007260 Adenosylhomocysteinase; Provisional; Region: PTZ00075 395095007261 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 395095007262 homotetramer interface [polypeptide binding]; other site 395095007263 ligand binding site [chemical binding]; other site 395095007264 catalytic site [active] 395095007265 NAD binding site [chemical binding]; other site 395095007266 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 395095007267 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 395095007268 Rubredoxin [Energy production and conversion]; Region: COG1773 395095007269 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 395095007270 iron binding site [ion binding]; other site 395095007271 Rubredoxin [Energy production and conversion]; Region: COG1773 395095007272 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 395095007273 iron binding site [ion binding]; other site 395095007274 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 395095007275 Fatty acid desaturase; Region: FA_desaturase; pfam00487 395095007276 Di-iron ligands [ion binding]; other site 395095007277 amino acid transporter; Region: 2A0306; TIGR00909 395095007278 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 395095007279 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 395095007280 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 395095007281 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 395095007282 active site 395095007283 substrate binding site [chemical binding]; other site 395095007284 metal binding site [ion binding]; metal-binding site 395095007285 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 395095007286 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 395095007287 LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186 395095007288 phosphate binding site [ion binding]; other site 395095007289 dimer interface [polypeptide binding]; other site 395095007290 substrate binding site [chemical binding]; other site 395095007291 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 395095007292 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 395095007293 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 395095007294 putative FMN binding site [chemical binding]; other site 395095007295 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 395095007296 Methyltransferase domain; Region: Methyltransf_26; pfam13659 395095007297 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 395095007298 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 395095007299 active site 395095007300 Substrate binding site; other site 395095007301 Mg++ binding site; other site 395095007302 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 395095007303 dTDP-4-dehydrorhamnose reductase; Region: rmlD; TIGR01214 395095007304 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 395095007305 NADP binding site [chemical binding]; other site 395095007306 active site 395095007307 putative substrate binding site [chemical binding]; other site 395095007308 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 395095007309 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 395095007310 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 395095007311 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 395095007312 active site 395095007313 motif I; other site 395095007314 motif II; other site 395095007315 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 395095007316 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 395095007317 CoA-transferase family III; Region: CoA_transf_3; pfam02515 395095007318 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 395095007319 Sulfate transporter family; Region: Sulfate_transp; pfam00916 395095007320 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: CynT; COG0288 395095007321 active site clefts [active] 395095007322 zinc binding site [ion binding]; other site 395095007323 dimer interface [polypeptide binding]; other site 395095007324 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 395095007325 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 395095007326 FAD binding site [chemical binding]; other site 395095007327 homotetramer interface [polypeptide binding]; other site 395095007328 substrate binding pocket [chemical binding]; other site 395095007329 catalytic base [active] 395095007330 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 395095007331 Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) [Nucleotide transport and metabolism]; Region: PurK; COG0026 395095007332 ATP-grasp domain; Region: ATP-grasp; pfam02222 395095007333 Predicted membrane protein [Function unknown]; Region: COG2246 395095007334 GtrA-like protein; Region: GtrA; pfam04138 395095007335 Bacterial PH domain; Region: DUF304; pfam03703 395095007336 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 395095007337 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 395095007338 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 395095007339 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 395095007340 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 395095007341 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 395095007342 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 395095007343 Maf-like protein; Region: Maf; pfam02545 395095007344 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 395095007345 active site 395095007346 dimer interface [polypeptide binding]; other site 395095007347 Fe-S metabolism associated domain; Region: SufE; pfam02657 395095007348 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 395095007349 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 395095007350 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 395095007351 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 395095007352 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 395095007353 carboxyltransferase (CT) interaction site; other site 395095007354 biotinylation site [posttranslational modification]; other site 395095007355 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 395095007356 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 395095007357 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 395095007358 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 395095007359 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 395095007360 L-lysine aminotransferase; Provisional; Region: PRK08297 395095007361 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 395095007362 inhibitor-cofactor binding pocket; inhibition site 395095007363 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395095007364 catalytic residue [active] 395095007365 putative DNA binding site [nucleotide binding]; other site 395095007366 dimerization interface [polypeptide binding]; other site 395095007367 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 395095007368 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 395095007369 putative Zn2+ binding site [ion binding]; other site 395095007370 AsnC family; Region: AsnC_trans_reg; pfam01037 395095007371 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 395095007372 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 395095007373 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 395095007374 tetrameric interface [polypeptide binding]; other site 395095007375 NAD binding site [chemical binding]; other site 395095007376 catalytic residues [active] 395095007377 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 395095007378 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 395095007379 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 395095007380 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 395095007381 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 395095007382 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 395095007383 Sulfatase; Region: Sulfatase; pfam00884 395095007384 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 395095007385 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 395095007386 probable active site [active] 395095007387 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 395095007388 PhoU domain; Region: PhoU; pfam01895 395095007389 PhoU domain; Region: PhoU; pfam01895 395095007390 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 395095007391 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 395095007392 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 395095007393 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 395095007394 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 395095007395 putative active site pocket [active] 395095007396 dimerization interface [polypeptide binding]; other site 395095007397 putative catalytic residue [active] 395095007398 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 395095007399 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 395095007400 metal binding site [ion binding]; metal-binding site 395095007401 putative dimer interface [polypeptide binding]; other site 395095007402 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 395095007403 amidohydrolase; Region: amidohydrolases; TIGR01891 395095007404 metal binding site [ion binding]; metal-binding site 395095007405 purine nucleoside phosphorylase; Provisional; Region: PRK08202 395095007406 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 395095007407 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 395095007408 active site 395095007409 substrate binding site [chemical binding]; other site 395095007410 metal binding site [ion binding]; metal-binding site 395095007411 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 395095007412 active site 395095007413 Phosphoesterase family; Region: Phosphoesterase; pfam04185 395095007414 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 395095007415 adenosine deaminase; Provisional; Region: PRK09358 395095007416 active site 395095007417 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 395095007418 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 395095007419 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 395095007420 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 395095007421 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 395095007422 putative Iron-sulfur protein interface [polypeptide binding]; other site 395095007423 putative proximal heme binding site [chemical binding]; other site 395095007424 putative SdhD-like interface [polypeptide binding]; other site 395095007425 putative distal heme binding site [chemical binding]; other site 395095007426 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 395095007427 putative Iron-sulfur protein interface [polypeptide binding]; other site 395095007428 putative proximal heme binding site [chemical binding]; other site 395095007429 putative SdhC-like subunit interface [polypeptide binding]; other site 395095007430 putative distal heme binding site [chemical binding]; other site 395095007431 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 395095007432 L-aspartate oxidase; Provisional; Region: PRK06175 395095007433 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 395095007434 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 395095007435 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 395095007436 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 395095007437 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 395095007438 MoaE interaction surface [polypeptide binding]; other site 395095007439 MoeB interaction surface [polypeptide binding]; other site 395095007440 thiocarboxylated glycine; other site 395095007441 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 395095007442 MoaE homodimer interface [polypeptide binding]; other site 395095007443 MoaD interaction [polypeptide binding]; other site 395095007444 active site residues [active] 395095007445 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 395095007446 aromatic arch; other site 395095007447 DCoH dimer interaction site [polypeptide binding]; other site 395095007448 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 395095007449 DCoH tetramer interaction site [polypeptide binding]; other site 395095007450 substrate binding site [chemical binding]; other site 395095007451 Molybdenum cofactor biosynthesis enzyme [Coenzyme metabolism]; Region: MoaA; COG2896 395095007452 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 395095007453 FeS/SAM binding site; other site 395095007454 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 395095007455 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 395095007456 Transposase; Region: HTH_Tnp_1; cl17663 395095007457 putative transposase OrfB; Reviewed; Region: PHA02517 395095007458 HTH-like domain; Region: HTH_21; pfam13276 395095007459 Integrase core domain; Region: rve; pfam00665 395095007460 Integrase core domain; Region: rve_3; pfam13683 395095007461 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 395095007462 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 395095007463 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 395095007464 DNA binding residues [nucleotide binding] 395095007465 SnoaL-like domain; Region: SnoaL_2; pfam12680 395095007466 hypothetical protein; Provisional; Region: PRK06541 395095007467 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 395095007468 inhibitor-cofactor binding pocket; inhibition site 395095007469 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395095007470 catalytic residue [active] 395095007471 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 395095007472 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 395095007473 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 395095007474 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 395095007475 active site 395095007476 dimer interface [polypeptide binding]; other site 395095007477 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 395095007478 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 395095007479 DNA binding residues [nucleotide binding] 395095007480 dimer interface [polypeptide binding]; other site 395095007481 metal binding site [ion binding]; metal-binding site 395095007482 inner membrane protein YhjD; Region: TIGR00766 395095007483 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 395095007484 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 395095007485 active site 395095007486 HIGH motif; other site 395095007487 dimer interface [polypeptide binding]; other site 395095007488 KMSKS motif; other site 395095007489 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 395095007490 isocitrate dehydrogenase; Validated; Region: PRK08299 395095007491 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 395095007492 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 395095007493 homodimer interface [polypeptide binding]; other site 395095007494 substrate-cofactor binding pocket; other site 395095007495 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395095007496 catalytic residue [active] 395095007497 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 395095007498 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 395095007499 Methyltransferase domain; Region: Methyltransf_23; pfam13489 395095007500 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395095007501 S-adenosylmethionine binding site [chemical binding]; other site 395095007502 Transposase; Region: DEDD_Tnp_IS110; pfam01548 395095007503 Berberine and berberine like; Region: BBE; pfam08031 395095007504 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 395095007505 Protein of unknown function (DUF732); Region: DUF732; pfam05305 395095007506 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 395095007507 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 395095007508 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 395095007509 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 395095007510 homodimer interface [polypeptide binding]; other site 395095007511 NADP binding site [chemical binding]; other site 395095007512 substrate binding site [chemical binding]; other site 395095007513 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 395095007514 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 395095007515 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 395095007516 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 395095007517 active site 395095007518 FMN binding site [chemical binding]; other site 395095007519 substrate binding site [chemical binding]; other site 395095007520 putative catalytic residue [active] 395095007521 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 395095007522 phosphate binding site [ion binding]; other site 395095007523 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 395095007524 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 395095007525 phosphopeptide binding site; other site 395095007526 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 395095007527 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395095007528 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 395095007529 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 395095007530 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 395095007531 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 395095007532 G1 box; other site 395095007533 GTP/Mg2+ binding site [chemical binding]; other site 395095007534 G2 box; other site 395095007535 Switch I region; other site 395095007536 G3 box; other site 395095007537 Switch II region; other site 395095007538 G4 box; other site 395095007539 G5 box; other site 395095007540 Protein of unknown function (DUF742); Region: DUF742; pfam05331 395095007541 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 395095007542 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 395095007543 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395095007544 ATP binding site [chemical binding]; other site 395095007545 Mg2+ binding site [ion binding]; other site 395095007546 G-X-G motif; other site 395095007547 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 395095007548 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 395095007549 FMN binding site [chemical binding]; other site 395095007550 dimer interface [polypeptide binding]; other site 395095007551 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 395095007552 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 395095007553 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 395095007554 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 395095007555 active site 395095007556 motif I; other site 395095007557 motif II; other site 395095007558 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 395095007559 substrate binding site [chemical binding]; other site 395095007560 oxyanion hole (OAH) forming residues; other site 395095007561 trimer interface [polypeptide binding]; other site 395095007562 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 395095007563 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 395095007564 Amidase; Region: Amidase; pfam01425 395095007565 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 395095007566 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 395095007567 motif II; other site 395095007568 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 395095007569 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 395095007570 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 395095007571 TPP-binding site [chemical binding]; other site 395095007572 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 395095007573 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 395095007574 PYR/PP interface [polypeptide binding]; other site 395095007575 dimer interface [polypeptide binding]; other site 395095007576 TPP binding site [chemical binding]; other site 395095007577 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 395095007578 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 395095007579 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 395095007580 substrate binding pocket [chemical binding]; other site 395095007581 chain length determination region; other site 395095007582 substrate-Mg2+ binding site; other site 395095007583 catalytic residues [active] 395095007584 aspartate-rich region 1; other site 395095007585 active site lid residues [active] 395095007586 aspartate-rich region 2; other site 395095007587 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 395095007588 putative active site [active] 395095007589 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 395095007590 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 395095007591 Transposase domain (DUF772); Region: DUF772; pfam05598 395095007592 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 395095007593 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 395095007594 enoyl-CoA hydratase; Region: PLN02864 395095007595 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 395095007596 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 395095007597 dimer interaction site [polypeptide binding]; other site 395095007598 substrate-binding tunnel; other site 395095007599 active site 395095007600 catalytic site [active] 395095007601 substrate binding site [chemical binding]; other site 395095007602 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 395095007603 short chain dehydrogenase; Provisional; Region: PRK07201 395095007604 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 395095007605 putative NAD(P) binding site [chemical binding]; other site 395095007606 active site 395095007607 putative substrate binding site [chemical binding]; other site 395095007608 classical (c) SDRs; Region: SDR_c; cd05233 395095007609 NAD(P) binding site [chemical binding]; other site 395095007610 active site 395095007611 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 395095007612 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395095007613 S-adenosylmethionine binding site [chemical binding]; other site 395095007614 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 395095007615 active site 395095007616 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 395095007617 active site lid residues [active] 395095007618 substrate binding pocket [chemical binding]; other site 395095007619 catalytic residues [active] 395095007620 substrate-Mg2+ binding site; other site 395095007621 aspartate-rich region 1; other site 395095007622 aspartate-rich region 2; other site 395095007623 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 395095007624 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 395095007625 substrate binding pocket [chemical binding]; other site 395095007626 chain length determination region; other site 395095007627 substrate-Mg2+ binding site; other site 395095007628 catalytic residues [active] 395095007629 aspartate-rich region 1; other site 395095007630 active site lid residues [active] 395095007631 aspartate-rich region 2; other site 395095007632 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 395095007633 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 395095007634 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 395095007635 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 395095007636 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 395095007637 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 395095007638 inhibitor-cofactor binding pocket; inhibition site 395095007639 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395095007640 catalytic residue [active] 395095007641 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 395095007642 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 395095007643 hypothetical protein; Provisional; Region: PRK07579 395095007644 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 395095007645 active site 395095007646 cosubstrate binding site; other site 395095007647 substrate binding site [chemical binding]; other site 395095007648 catalytic site [active] 395095007649 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 395095007650 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 395095007651 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 395095007652 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 395095007653 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 395095007654 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 395095007655 putative active site [active] 395095007656 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 395095007657 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 395095007658 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 395095007659 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 395095007660 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 395095007661 phosphate binding site [ion binding]; other site 395095007662 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 395095007663 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 395095007664 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 395095007665 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 395095007666 active site 395095007667 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 395095007668 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 395095007669 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 395095007670 DNA binding residues [nucleotide binding] 395095007671 Transcription factor WhiB; Region: Whib; pfam02467 395095007672 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 395095007673 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 395095007674 ring oligomerisation interface [polypeptide binding]; other site 395095007675 ATP/Mg binding site [chemical binding]; other site 395095007676 stacking interactions; other site 395095007677 hinge regions; other site 395095007678 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 395095007679 oligomerisation interface [polypeptide binding]; other site 395095007680 mobile loop; other site 395095007681 roof hairpin; other site 395095007682 UGMP family protein; Validated; Region: PRK09604 395095007683 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 395095007684 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 395095007685 alanine racemase; Reviewed; Region: alr; PRK00053 395095007686 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 395095007687 active site 395095007688 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 395095007689 dimer interface [polypeptide binding]; other site 395095007690 substrate binding site [chemical binding]; other site 395095007691 catalytic residues [active] 395095007692 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 395095007693 PPE family; Region: PPE; pfam00823 395095007694 Integrase core domain; Region: rve; pfam00665 395095007695 Integrase core domain; Region: rve_3; pfam13683 395095007696 Transposase, Mutator family; Region: Transposase_mut; pfam00872 395095007697 MULE transposase domain; Region: MULE; pfam10551 395095007698 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 395095007699 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395095007700 catalytic residue [active] 395095007701 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 395095007702 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 395095007703 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 395095007704 active site 395095007705 substrate binding site [chemical binding]; other site 395095007706 metal binding site [ion binding]; metal-binding site 395095007707 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 395095007708 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 395095007709 23S rRNA interface [nucleotide binding]; other site 395095007710 L3 interface [polypeptide binding]; other site 395095007711 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 395095007712 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 395095007713 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 395095007714 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 395095007715 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 395095007716 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 395095007717 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 395095007718 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 395095007719 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 395095007720 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 395095007721 active site 395095007722 catalytic residues [active] 395095007723 Cutinase; Region: Cutinase; pfam01083 395095007724 Cutinase; Region: Cutinase; pfam01083 395095007725 Pseudouridylate synthase [Translation, ribosomal structure and biogenesis]; Region: TruA; COG0101 395095007726 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 395095007727 dimerization interface 3.5A [polypeptide binding]; other site 395095007728 active site 395095007729 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 395095007730 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 395095007731 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 395095007732 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 395095007733 RNA binding surface [nucleotide binding]; other site 395095007734 30S ribosomal protein S11; Validated; Region: PRK05309 395095007735 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 395095007736 30S ribosomal protein S13; Region: bact_S13; TIGR03631 395095007737 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 395095007738 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 395095007739 rRNA binding site [nucleotide binding]; other site 395095007740 predicted 30S ribosome binding site; other site 395095007741 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 395095007742 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 395095007743 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 395095007744 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 395095007745 NAD binding site [chemical binding]; other site 395095007746 substrate binding site [chemical binding]; other site 395095007747 homodimer interface [polypeptide binding]; other site 395095007748 active site 395095007749 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 395095007750 Protein of unknown function (DUF2742); Region: DUF2742; pfam10888 395095007751 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: COG3747 395095007752 Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653 395095007753 Phage capsid family; Region: Phage_capsid; pfam05065 395095007754 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 395095007755 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 395095007756 active site 395095007757 catalytic residues [active] 395095007758 metal binding site [ion binding]; metal-binding site 395095007759 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 395095007760 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 395095007761 PYR/PP interface [polypeptide binding]; other site 395095007762 dimer interface [polypeptide binding]; other site 395095007763 TPP binding site [chemical binding]; other site 395095007764 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 395095007765 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 395095007766 TPP-binding site [chemical binding]; other site 395095007767 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 395095007768 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 395095007769 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 395095007770 metabolite-proton symporter; Region: 2A0106; TIGR00883 395095007771 putative substrate translocation pore; other site 395095007772 PE family; Region: PE; pfam00934 395095007773 patatin-related protein; Region: TIGR03607 395095007774 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 395095007775 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 395095007776 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 395095007777 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 395095007778 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 395095007779 Transcriptional regulator [Transcription]; Region: LytR; COG1316 395095007780 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 395095007781 short chain dehydrogenase; Provisional; Region: PRK05875 395095007782 classical (c) SDRs; Region: SDR_c; cd05233 395095007783 NAD(P) binding site [chemical binding]; other site 395095007784 active site 395095007785 Predicted membrane protein [Function unknown]; Region: COG2259 395095007786 Predicted transcriptional regulators [Transcription]; Region: COG1695 395095007787 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 395095007788 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 395095007789 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 395095007790 active site 395095007791 homotetramer interface [polypeptide binding]; other site 395095007792 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 395095007793 mce related protein; Region: MCE; pfam02470 395095007794 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 395095007795 mce related protein; Region: MCE; pfam02470 395095007796 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 395095007797 mce related protein; Region: MCE; pfam02470 395095007798 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 395095007799 mce related protein; Region: MCE; pfam02470 395095007800 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 395095007801 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 395095007802 Permease; Region: Permease; pfam02405 395095007803 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 395095007804 Permease; Region: Permease; pfam02405 395095007805 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 395095007806 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395095007807 NAD(P) binding site [chemical binding]; other site 395095007808 active site 395095007809 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 395095007810 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 395095007811 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 395095007812 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 395095007813 FAD binding site [chemical binding]; other site 395095007814 substrate binding site [chemical binding]; other site 395095007815 catalytic base [active] 395095007816 acyl-CoA synthetase; Validated; Region: PRK07867 395095007817 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 395095007818 acyl-activating enzyme (AAE) consensus motif; other site 395095007819 putative AMP binding site [chemical binding]; other site 395095007820 putative active site [active] 395095007821 putative CoA binding site [chemical binding]; other site 395095007822 hypothetical protein; Validated; Region: PRK07586 395095007823 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 395095007824 PYR/PP interface [polypeptide binding]; other site 395095007825 dimer interface [polypeptide binding]; other site 395095007826 TPP binding site [chemical binding]; other site 395095007827 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 395095007828 TPP-binding site [chemical binding]; other site 395095007829 dimer interface [polypeptide binding]; other site 395095007830 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 395095007831 acyl-CoA synthetase; Validated; Region: PRK07798 395095007832 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 395095007833 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 395095007834 acyl-activating enzyme (AAE) consensus motif; other site 395095007835 acyl-activating enzyme (AAE) consensus motif; other site 395095007836 putative AMP binding site [chemical binding]; other site 395095007837 putative active site [active] 395095007838 putative CoA binding site [chemical binding]; other site 395095007839 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 395095007840 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 395095007841 Cytochrome P450; Region: p450; cl12078 395095007842 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 395095007843 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 395095007844 DUF35 OB-fold domain; Region: DUF35; pfam01796 395095007845 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 395095007846 DUF35 OB-fold domain; Region: DUF35; pfam01796 395095007847 lipid-transfer protein; Provisional; Region: PRK07937 395095007848 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 395095007849 active site 395095007850 NHL repeat; Region: NHL; pfam01436 395095007851 Uncharacterized conserved protein [Function unknown]; Region: COG3391 395095007852 NHL repeat; Region: NHL; pfam01436 395095007853 NHL repeat; Region: NHL; pfam01436 395095007854 NHL repeat; Region: NHL; pfam01436 395095007855 NHL repeat; Region: NHL; pfam01436 395095007856 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 395095007857 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 395095007858 trimer interface [polypeptide binding]; other site 395095007859 putative metal binding site [ion binding]; other site 395095007860 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 395095007861 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 395095007862 short chain dehydrogenase; Provisional; Region: PRK07890 395095007863 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395095007864 NAD(P) binding site [chemical binding]; other site 395095007865 active site 395095007866 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 395095007867 PPE family; Region: PPE; pfam00823 395095007868 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 395095007869 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 395095007870 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 395095007871 active site 395095007872 catalytic residues [active] 395095007873 metal binding site [ion binding]; metal-binding site 395095007874 DmpG-like communication domain; Region: DmpG_comm; pfam07836 395095007875 acetaldehyde dehydrogenase; Validated; Region: PRK08300 395095007876 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 395095007877 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 395095007878 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971 395095007879 enoyl-CoA hydratase; Region: PLN02864 395095007880 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 395095007881 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 395095007882 dimer interaction site [polypeptide binding]; other site 395095007883 substrate-binding tunnel; other site 395095007884 active site 395095007885 catalytic site [active] 395095007886 substrate binding site [chemical binding]; other site 395095007887 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 395095007888 PPE family; Region: PPE; pfam00823 395095007889 PE-PPE domain; Region: PE-PPE; pfam08237 395095007890 lipid-transfer protein; Provisional; Region: PRK07855 395095007891 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 395095007892 active site 395095007893 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 395095007894 putative active site [active] 395095007895 putative catalytic site [active] 395095007896 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 395095007897 active site 395095007898 catalytic site [active] 395095007899 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 395095007900 DUF35 OB-fold domain; Region: DUF35; pfam01796 395095007901 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 395095007902 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 395095007903 active site 395095007904 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 395095007905 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 395095007906 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 395095007907 active site 395095007908 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 395095007909 Cytochrome P450; Region: p450; cl12078 395095007910 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 395095007911 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 395095007912 dimer interface [polypeptide binding]; other site 395095007913 active site 395095007914 Domain of unknown function (DUF385); Region: DUF385; pfam04075 395095007915 short chain dehydrogenase; Provisional; Region: PRK07791 395095007916 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 395095007917 homodimer interface [polypeptide binding]; other site 395095007918 NAD binding site [chemical binding]; other site 395095007919 active site 395095007920 short chain dehydrogenase; Provisional; Region: PRK07856 395095007921 classical (c) SDRs; Region: SDR_c; cd05233 395095007922 NAD(P) binding site [chemical binding]; other site 395095007923 active site 395095007924 enoyl-CoA hydratase; Provisional; Region: PRK06495 395095007925 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 395095007926 substrate binding site [chemical binding]; other site 395095007927 oxyanion hole (OAH) forming residues; other site 395095007928 trimer interface [polypeptide binding]; other site 395095007929 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 395095007930 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057 395095007931 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 395095007932 Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514 395095007933 putative di-iron ligands [ion binding]; other site 395095007934 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 395095007935 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 395095007936 FAD binding pocket [chemical binding]; other site 395095007937 FAD binding motif [chemical binding]; other site 395095007938 phosphate binding motif [ion binding]; other site 395095007939 beta-alpha-beta structure motif; other site 395095007940 NAD(p) ribose binding residues [chemical binding]; other site 395095007941 NAD binding pocket [chemical binding]; other site 395095007942 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 395095007943 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 395095007944 catalytic loop [active] 395095007945 iron binding site [ion binding]; other site 395095007946 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 395095007947 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 395095007948 putative active site [active] 395095007949 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 395095007950 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 395095007951 dimer interface [polypeptide binding]; other site 395095007952 active site 395095007953 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 395095007954 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 395095007955 short chain dehydrogenase; Provisional; Region: PRK07831 395095007956 classical (c) SDRs; Region: SDR_c; cd05233 395095007957 NAD(P) binding site [chemical binding]; other site 395095007958 active site 395095007959 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 395095007960 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 395095007961 active site 395095007962 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 395095007963 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 395095007964 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 395095007965 acyl-activating enzyme (AAE) consensus motif; other site 395095007966 putative AMP binding site [chemical binding]; other site 395095007967 putative active site [active] 395095007968 putative CoA binding site [chemical binding]; other site 395095007969 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 395095007970 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 395095007971 active site 395095007972 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 395095007973 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 395095007974 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 395095007975 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 395095007976 active site 395095007977 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 395095007978 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 395095007979 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 395095007980 active site 395095007981 aspartate aminotransferase; Provisional; Region: PRK05764 395095007982 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 395095007983 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395095007984 homodimer interface [polypeptide binding]; other site 395095007985 catalytic residue [active] 395095007986 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 395095007987 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 395095007988 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 395095007989 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 395095007990 active site 395095007991 Fe binding site [ion binding]; other site 395095007992 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 395095007993 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 395095007994 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 395095007995 Flavin binding site [chemical binding]; other site 395095007996 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 395095007997 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 395095007998 FAD binding pocket [chemical binding]; other site 395095007999 FAD binding motif [chemical binding]; other site 395095008000 phosphate binding motif [ion binding]; other site 395095008001 beta-alpha-beta structure motif; other site 395095008002 NAD(p) ribose binding residues [chemical binding]; other site 395095008003 NAD binding pocket [chemical binding]; other site 395095008004 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 395095008005 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 395095008006 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 395095008007 catalytic loop [active] 395095008008 iron binding site [ion binding]; other site 395095008009 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 395095008010 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 395095008011 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 395095008012 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 395095008013 active site 395095008014 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 395095008015 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 395095008016 PknH-like extracellular domain; Region: PknH_C; pfam14032 395095008017 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 395095008018 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 395095008019 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 395095008020 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 395095008021 active site 395095008022 HIGH motif; other site 395095008023 nucleotide binding site [chemical binding]; other site 395095008024 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 395095008025 KMSKS motif; other site 395095008026 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 395095008027 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 395095008028 homotrimer interaction site [polypeptide binding]; other site 395095008029 zinc binding site [ion binding]; other site 395095008030 CDP-binding sites; other site 395095008031 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 395095008032 substrate binding site; other site 395095008033 dimer interface; other site 395095008034 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 395095008035 DNA repair protein RadA; Provisional; Region: PRK11823 395095008036 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 395095008037 Walker A motif/ATP binding site; other site 395095008038 ATP binding site [chemical binding]; other site 395095008039 Walker B motif; other site 395095008040 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 395095008041 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 395095008042 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 395095008043 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 395095008044 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 395095008045 active site clefts [active] 395095008046 zinc binding site [ion binding]; other site 395095008047 dimer interface [polypeptide binding]; other site 395095008048 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 395095008049 endonuclease III; Region: ENDO3c; smart00478 395095008050 minor groove reading motif; other site 395095008051 helix-hairpin-helix signature motif; other site 395095008052 substrate binding pocket [chemical binding]; other site 395095008053 active site 395095008054 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 395095008055 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 395095008056 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 395095008057 catalytic site [active] 395095008058 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 395095008059 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 395095008060 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 395095008061 Lsr2; Region: Lsr2; pfam11774 395095008062 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 395095008063 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 395095008064 dimer interface [polypeptide binding]; other site 395095008065 putative anticodon binding site; other site 395095008066 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 395095008067 motif 1; other site 395095008068 dimer interface [polypeptide binding]; other site 395095008069 active site 395095008070 motif 2; other site 395095008071 motif 3; other site 395095008072 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 395095008073 tetramerization interface [polypeptide binding]; other site 395095008074 active site 395095008075 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 395095008076 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 395095008077 catalytic center binding site [active] 395095008078 ATP binding site [chemical binding]; other site 395095008079 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 395095008080 homooctamer interface [polypeptide binding]; other site 395095008081 active site 395095008082 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 395095008083 dihydropteroate synthase; Region: DHPS; TIGR01496 395095008084 substrate binding pocket [chemical binding]; other site 395095008085 dimer interface [polypeptide binding]; other site 395095008086 inhibitor binding site; inhibition site 395095008087 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 395095008088 homodecamer interface [polypeptide binding]; other site 395095008089 GTP cyclohydrolase I; Provisional; Region: PLN03044 395095008090 active site 395095008091 putative catalytic site residues [active] 395095008092 zinc binding site [ion binding]; other site 395095008093 GTP-CH-I/GFRP interaction surface; other site 395095008094 FtsH Extracellular; Region: FtsH_ext; pfam06480 395095008095 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 395095008096 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395095008097 Walker A motif; other site 395095008098 ATP binding site [chemical binding]; other site 395095008099 Walker B motif; other site 395095008100 arginine finger; other site 395095008101 Peptidase family M41; Region: Peptidase_M41; pfam01434 395095008102 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 395095008103 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 395095008104 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 395095008105 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 395095008106 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 395095008107 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 395095008108 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 395095008109 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 395095008110 PPE family; Region: PPE; pfam00823 395095008111 PE family; Region: PE; pfam00934 395095008112 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 395095008113 active site 395095008114 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 395095008115 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 395095008116 Ligand Binding Site [chemical binding]; other site 395095008117 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113 395095008118 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 395095008119 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 395095008120 dimer interface [polypeptide binding]; other site 395095008121 substrate binding site [chemical binding]; other site 395095008122 metal binding sites [ion binding]; metal-binding site 395095008123 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2899 395095008124 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 395095008125 Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5285 395095008126 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 395095008127 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 395095008128 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 395095008129 transposase; Provisional; Region: PRK06526 395095008130 IstB-like ATP binding protein; Region: IstB_IS21; pfam01695 395095008131 Walker B motif; other site 395095008132 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 395095008133 Fic/DOC family; Region: Fic; cl00960 395095008134 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 395095008135 dimerization interface [polypeptide binding]; other site 395095008136 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 395095008137 cyclase homology domain; Region: CHD; cd07302 395095008138 nucleotidyl binding site; other site 395095008139 metal binding site [ion binding]; metal-binding site 395095008140 dimer interface [polypeptide binding]; other site 395095008141 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 395095008142 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 395095008143 active site 395095008144 interdomain interaction site; other site 395095008145 putative metal-binding site [ion binding]; other site 395095008146 nucleotide binding site [chemical binding]; other site 395095008147 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 395095008148 domain I; other site 395095008149 phosphate binding site [ion binding]; other site 395095008150 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 395095008151 domain II; other site 395095008152 domain III; other site 395095008153 nucleotide binding site [chemical binding]; other site 395095008154 DNA binding groove [nucleotide binding] 395095008155 catalytic site [active] 395095008156 domain IV; other site 395095008157 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 395095008158 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 395095008159 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 395095008160 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 395095008161 DNA-binding site [nucleotide binding]; DNA binding site 395095008162 RNA-binding motif; other site 395095008163 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 395095008164 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 395095008165 ATP binding site [chemical binding]; other site 395095008166 putative Mg++ binding site [ion binding]; other site 395095008167 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 395095008168 nucleotide binding region [chemical binding]; other site 395095008169 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 395095008170 PE family; Region: PE; pfam00934 395095008171 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 395095008172 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 395095008173 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 395095008174 motif II; other site 395095008175 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 395095008176 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 395095008177 Walker A/P-loop; other site 395095008178 ATP binding site [chemical binding]; other site 395095008179 Q-loop/lid; other site 395095008180 ABC transporter signature motif; other site 395095008181 Walker B; other site 395095008182 D-loop; other site 395095008183 H-loop/switch region; other site 395095008184 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 395095008185 Walker A/P-loop; other site 395095008186 ATP binding site [chemical binding]; other site 395095008187 Q-loop/lid; other site 395095008188 ABC transporter signature motif; other site 395095008189 Walker B; other site 395095008190 D-loop; other site 395095008191 H-loop/switch region; other site 395095008192 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 395095008193 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 395095008194 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395095008195 dimer interface [polypeptide binding]; other site 395095008196 conserved gate region; other site 395095008197 ABC-ATPase subunit interface; other site 395095008198 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 395095008199 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 395095008200 acetyl-CoA synthetase; Provisional; Region: PRK00174 395095008201 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 395095008202 active site 395095008203 CoA binding site [chemical binding]; other site 395095008204 acyl-activating enzyme (AAE) consensus motif; other site 395095008205 AMP binding site [chemical binding]; other site 395095008206 acetate binding site [chemical binding]; other site 395095008207 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 395095008208 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 395095008209 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 395095008210 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 395095008211 putative active site [active] 395095008212 putative CoA binding site [chemical binding]; other site 395095008213 nudix motif; other site 395095008214 metal binding site [ion binding]; metal-binding site 395095008215 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 395095008216 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 395095008217 catalytic residues [active] 395095008218 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 395095008219 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 395095008220 minor groove reading motif; other site 395095008221 helix-hairpin-helix signature motif; other site 395095008222 substrate binding pocket [chemical binding]; other site 395095008223 active site 395095008224 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 395095008225 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 395095008226 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 395095008227 ligand binding site [chemical binding]; other site 395095008228 flexible hinge region; other site 395095008229 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 395095008230 putative switch regulator; other site 395095008231 non-specific DNA interactions [nucleotide binding]; other site 395095008232 DNA binding site [nucleotide binding] 395095008233 sequence specific DNA binding site [nucleotide binding]; other site 395095008234 putative cAMP binding site [chemical binding]; other site 395095008235 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 395095008236 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 395095008237 homotrimer interaction site [polypeptide binding]; other site 395095008238 putative active site [active] 395095008239 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 395095008240 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 395095008241 P loop; other site 395095008242 Nucleotide binding site [chemical binding]; other site 395095008243 DTAP/Switch II; other site 395095008244 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 395095008245 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 395095008246 DTAP/Switch II; other site 395095008247 Switch I; other site 395095008248 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 395095008249 Transcription factor WhiB; Region: Whib; pfam02467 395095008250 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 395095008251 Transglycosylase; Region: Transgly; pfam00912 395095008252 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 395095008253 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 395095008254 phosphodiesterase YaeI; Provisional; Region: PRK11340 395095008255 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 395095008256 putative active site [active] 395095008257 putative metal binding site [ion binding]; other site 395095008258 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 395095008259 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 395095008260 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 395095008261 catalytic residue [active] 395095008262 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 395095008263 Cytochrome P450; Region: p450; cl12078 395095008264 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 395095008265 anti sigma factor interaction site; other site 395095008266 regulatory phosphorylation site [posttranslational modification]; other site 395095008267 Uncharacterized conserved protein [Function unknown]; Region: COG1610 395095008268 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 395095008269 MoxR-like ATPases [General function prediction only]; Region: COG0714 395095008270 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395095008271 Walker A motif; other site 395095008272 ATP binding site [chemical binding]; other site 395095008273 Walker B motif; other site 395095008274 arginine finger; other site 395095008275 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 395095008276 Predicted membrane protein/domain [Function unknown]; Region: COG1714 395095008277 glycerol kinase; Provisional; Region: glpK; PRK00047 395095008278 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 395095008279 nucleotide binding site [chemical binding]; other site 395095008280 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 395095008281 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 395095008282 Methyltransferase domain; Region: Methyltransf_23; pfam13489 395095008283 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395095008284 S-adenosylmethionine binding site [chemical binding]; other site 395095008285 Uncharacterized conserved protein [Function unknown]; Region: COG4301 395095008286 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 395095008287 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 395095008288 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 395095008289 putative active site [active] 395095008290 putative dimer interface [polypeptide binding]; other site 395095008291 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 395095008292 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 395095008293 Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG3572 395095008294 PknH-like extracellular domain; Region: PknH_C; pfam14032 395095008295 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 395095008296 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 395095008297 aspartate kinase; Reviewed; Region: PRK06635 395095008298 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 395095008299 putative nucleotide binding site [chemical binding]; other site 395095008300 putative catalytic residues [active] 395095008301 putative Mg ion binding site [ion binding]; other site 395095008302 putative aspartate binding site [chemical binding]; other site 395095008303 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 395095008304 putative allosteric regulatory site; other site 395095008305 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 395095008306 putative allosteric regulatory residue; other site 395095008307 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 395095008308 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 395095008309 active site 395095008310 catalytic site [active] 395095008311 substrate binding site [chemical binding]; other site 395095008312 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 395095008313 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 395095008314 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 395095008315 catalytic triad [active] 395095008316 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 395095008317 putative active site [active] 395095008318 recombination protein RecR; Reviewed; Region: recR; PRK00076 395095008319 RecR protein; Region: RecR; pfam02132 395095008320 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 395095008321 putative active site [active] 395095008322 putative metal-binding site [ion binding]; other site 395095008323 tetramer interface [polypeptide binding]; other site 395095008324 hypothetical protein; Validated; Region: PRK00153 395095008325 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 395095008326 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 395095008327 active site 395095008328 metal binding site [ion binding]; metal-binding site 395095008329 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 395095008330 hydrophobic ligand binding site; other site 395095008331 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 395095008332 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395095008333 S-adenosylmethionine binding site [chemical binding]; other site 395095008334 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14952 395095008335 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395095008336 Walker A motif; other site 395095008337 ATP binding site [chemical binding]; other site 395095008338 Walker B motif; other site 395095008339 arginine finger; other site 395095008340 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 395095008341 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 395095008342 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 395095008343 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 395095008344 catalytic residue [active] 395095008345 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395095008346 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 395095008347 NAD(P) binding site [chemical binding]; other site 395095008348 active site 395095008349 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 395095008350 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 395095008351 putative NAD(P) binding site [chemical binding]; other site 395095008352 catalytic Zn binding site [ion binding]; other site 395095008353 Uncharacterized conserved protein [Function unknown]; Region: COG3349 395095008354 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 395095008355 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 395095008356 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 395095008357 putative substrate translocation pore; other site 395095008358 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 395095008359 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 395095008360 ligand binding site [chemical binding]; other site 395095008361 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 395095008362 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 395095008363 active site 395095008364 nucleophile elbow; other site 395095008365 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 395095008366 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 395095008367 active site 395095008368 DNA binding site [nucleotide binding] 395095008369 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 395095008370 DNA binding site [nucleotide binding] 395095008371 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4402 395095008372 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_5; cd04662 395095008373 nudix motif; other site 395095008374 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 395095008375 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 395095008376 Uncharacterized conserved protein [Function unknown]; Region: COG1839 395095008377 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 395095008378 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 395095008379 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 395095008380 Uncharacterized conserved protein [Function unknown]; Region: COG2966 395095008381 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 395095008382 Uncharacterized conserved protein [Function unknown]; Region: COG3610 395095008383 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 395095008384 PPE family; Region: PPE; pfam00823 395095008385 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 395095008386 PPE family; Region: PPE; pfam00823 395095008387 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 395095008388 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 395095008389 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 395095008390 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 395095008391 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 395095008392 Soluble P-type ATPase [General function prediction only]; Region: COG4087 395095008393 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 395095008394 dimerization interface [polypeptide binding]; other site 395095008395 putative DNA binding site [nucleotide binding]; other site 395095008396 putative Zn2+ binding site [ion binding]; other site 395095008397 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3651 395095008398 DNA binding domain, excisionase family; Region: excise; TIGR01764 395095008399 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 395095008400 active site 395095008401 Int/Topo IB signature motif; other site 395095008402 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 395095008403 nucleoside/Zn binding site; other site 395095008404 dimer interface [polypeptide binding]; other site 395095008405 catalytic motif [active] 395095008406 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3554 395095008407 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395095008408 ABC-ATPase subunit interface; other site 395095008409 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 395095008410 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 395095008411 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 395095008412 Walker A/P-loop; other site 395095008413 ATP binding site [chemical binding]; other site 395095008414 Q-loop/lid; other site 395095008415 ABC transporter signature motif; other site 395095008416 Walker B; other site 395095008417 D-loop; other site 395095008418 H-loop/switch region; other site 395095008419 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 395095008420 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 395095008421 putative active site [active] 395095008422 putative substrate binding site [chemical binding]; other site 395095008423 ATP binding site [chemical binding]; other site 395095008424 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 395095008425 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 395095008426 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 395095008427 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 395095008428 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 395095008429 SnoaL-like domain; Region: SnoaL_2; pfam12680 395095008430 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 395095008431 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 395095008432 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395095008433 homodimer interface [polypeptide binding]; other site 395095008434 catalytic residue [active] 395095008435 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 395095008436 TIGR03086 family protein; Region: TIGR03086 395095008437 enoyl-CoA hydratase; Provisional; Region: PRK06142 395095008438 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 395095008439 substrate binding site [chemical binding]; other site 395095008440 oxyanion hole (OAH) forming residues; other site 395095008441 trimer interface [polypeptide binding]; other site 395095008442 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 395095008443 Beta-lactamase; Region: Beta-lactamase; pfam00144 395095008444 Domain of unknown function (DUF222); Region: DUF222; pfam02720 395095008445 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 395095008446 active site 395095008447 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 395095008448 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 395095008449 NAD(P) binding site [chemical binding]; other site 395095008450 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 395095008451 cysteine desulfurase family protein, VC1184 subfamily; Region: am_tr_V_VC1184; TIGR01976 395095008452 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 395095008453 catalytic residue [active] 395095008454 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 395095008455 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 395095008456 Walker A/P-loop; other site 395095008457 ATP binding site [chemical binding]; other site 395095008458 Q-loop/lid; other site 395095008459 ABC transporter signature motif; other site 395095008460 Walker B; other site 395095008461 D-loop; other site 395095008462 H-loop/switch region; other site 395095008463 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 395095008464 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 395095008465 active site 395095008466 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 395095008467 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 395095008468 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 395095008469 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 395095008470 NAD binding site [chemical binding]; other site 395095008471 substrate binding site [chemical binding]; other site 395095008472 active site 395095008473 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 395095008474 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 395095008475 active site 395095008476 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 395095008477 Peptidase family M23; Region: Peptidase_M23; pfam01551 395095008478 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 395095008479 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 395095008480 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05892 395095008481 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 395095008482 Predicted membrane protein [Function unknown]; Region: COG2246 395095008483 GtrA-like protein; Region: GtrA; pfam04138 395095008484 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 395095008485 FAD binding domain; Region: FAD_binding_4; pfam01565 395095008486 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 395095008487 short chain dehydrogenase; Provisional; Region: PRK07904 395095008488 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 395095008489 NAD(P) binding site [chemical binding]; other site 395095008490 active site 395095008491 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 395095008492 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 395095008493 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 395095008494 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 395095008495 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 395095008496 FAD binding site [chemical binding]; other site 395095008497 substrate binding site [chemical binding]; other site 395095008498 catalytic residues [active] 395095008499 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 395095008500 Transposase; Region: DDE_Tnp_ISL3; pfam01610 395095008501 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 395095008502 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 395095008503 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 395095008504 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 395095008505 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 395095008506 acyl-activating enzyme (AAE) consensus motif; other site 395095008507 active site 395095008508 Cutinase; Region: Cutinase; pfam01083 395095008509 Predicted esterase [General function prediction only]; Region: COG0627 395095008510 Putative esterase; Region: Esterase; pfam00756 395095008511 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 395095008512 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 395095008513 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 395095008514 active site 395095008515 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 395095008516 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 395095008517 UDP-galactopyranose mutase; Region: GLF; pfam03275 395095008518 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 395095008519 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 395095008520 amidase catalytic site [active] 395095008521 Zn binding residues [ion binding]; other site 395095008522 substrate binding site [chemical binding]; other site 395095008523 LGFP repeat; Region: LGFP; pfam08310 395095008524 PE family; Region: PE; pfam00934 395095008525 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 395095008526 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 395095008527 active site 395095008528 motif I; other site 395095008529 motif II; other site 395095008530 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 395095008531 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 395095008532 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 395095008533 putative acyl-acceptor binding pocket; other site 395095008534 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 395095008535 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 395095008536 putative acyl-acceptor binding pocket; other site 395095008537 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 395095008538 Phosphotransferase enzyme family; Region: APH; pfam01636 395095008539 active site 395095008540 ATP binding site [chemical binding]; other site 395095008541 antibiotic binding site [chemical binding]; other site 395095008542 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 395095008543 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 395095008544 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 395095008545 iron-sulfur cluster [ion binding]; other site 395095008546 [2Fe-2S] cluster binding site [ion binding]; other site 395095008547 Condensation domain; Region: Condensation; pfam00668 395095008548 PE-PPE domain; Region: PE-PPE; pfam08237 395095008549 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 395095008550 Condensation domain; Region: Condensation; pfam00668 395095008551 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 395095008552 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 395095008553 active site 395095008554 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 395095008555 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 395095008556 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395095008557 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 395095008558 Enoylreductase; Region: PKS_ER; smart00829 395095008559 NAD(P) binding site [chemical binding]; other site 395095008560 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 395095008561 KR domain; Region: KR; pfam08659 395095008562 putative NADP binding site [chemical binding]; other site 395095008563 active site 395095008564 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 395095008565 acyl-CoA synthetase; Validated; Region: PRK05850 395095008566 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 395095008567 acyl-activating enzyme (AAE) consensus motif; other site 395095008568 active site 395095008569 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 395095008570 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 395095008571 catalytic residues [active] 395095008572 catalytic nucleophile [active] 395095008573 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 395095008574 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 395095008575 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 395095008576 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 395095008577 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 395095008578 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395095008579 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 395095008580 Cupin domain; Region: Cupin_2; cl17218 395095008581 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 395095008582 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 395095008583 Septum formation; Region: Septum_form; pfam13845 395095008584 Septum formation; Region: Septum_form; pfam13845 395095008585 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 395095008586 catalytic core [active] 395095008587 prephenate dehydratase; Provisional; Region: PRK11898 395095008588 Prephenate dehydratase; Region: PDT; pfam00800 395095008589 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 395095008590 putative L-Phe binding site [chemical binding]; other site 395095008591 Transcriptional regulator [Transcription]; Region: LytR; COG1316 395095008592 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 395095008593 Ferritin-like domain; Region: Ferritin; pfam00210 395095008594 ferroxidase diiron center [ion binding]; other site 395095008595 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 395095008596 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 395095008597 putative active site [active] 395095008598 catalytic site [active] 395095008599 putative metal binding site [ion binding]; other site 395095008600 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 395095008601 Transposase; Region: DEDD_Tnp_IS110; pfam01548 395095008602 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 395095008603 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 395095008604 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 395095008605 Predicted membrane protein [Function unknown]; Region: COG2119 395095008606 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 395095008607 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 395095008608 Fimbrial protein; Region: Fimbrial; cl01416 395095008609 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 395095008610 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 395095008611 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 395095008612 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 395095008613 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 395095008614 hypothetical protein; Provisional; Region: PRK07945 395095008615 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 395095008616 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 395095008617 active site 395095008618 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 395095008619 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 395095008620 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 395095008621 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 395095008622 active site 395095008623 dimer interface [polypeptide binding]; other site 395095008624 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 395095008625 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 395095008626 active site 395095008627 FMN binding site [chemical binding]; other site 395095008628 substrate binding site [chemical binding]; other site 395095008629 3Fe-4S cluster binding site [ion binding]; other site 395095008630 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 395095008631 domain interface; other site 395095008632 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 395095008633 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 395095008634 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 395095008635 EspG family; Region: ESX-1_EspG; pfam14011 395095008636 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 395095008637 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395095008638 Walker A motif; other site 395095008639 ATP binding site [chemical binding]; other site 395095008640 Walker B motif; other site 395095008641 arginine finger; other site 395095008642 Protein of unknown function (DUF690); Region: DUF690; pfam05108 395095008643 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 395095008644 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 395095008645 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 395095008646 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 395095008647 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 395095008648 PE family; Region: PE; pfam00934 395095008649 Proteins of 100 residues with WXG; Region: WXG100; cl02005 395095008650 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 395095008651 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 395095008652 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 395095008653 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 395095008654 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 395095008655 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 395095008656 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 395095008657 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 395095008658 PPE family; Region: PPE; pfam00823 395095008659 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 395095008660 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 395095008661 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 395095008662 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 395095008663 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 395095008664 Protein of unknown function (DUF690); Region: DUF690; pfam05108 395095008665 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 395095008666 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 395095008667 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 395095008668 active site 395095008669 NTP binding site [chemical binding]; other site 395095008670 metal binding triad [ion binding]; metal-binding site 395095008671 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 395095008672 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 395095008673 Zn2+ binding site [ion binding]; other site 395095008674 Mg2+ binding site [ion binding]; other site 395095008675 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 395095008676 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 395095008677 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 395095008678 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 395095008679 DNA binding residues [nucleotide binding] 395095008680 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 395095008681 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 395095008682 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 395095008683 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 395095008684 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 395095008685 catalytic residues [active] 395095008686 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 395095008687 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 395095008688 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 395095008689 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 395095008690 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 395095008691 active site 395095008692 metal binding site [ion binding]; metal-binding site 395095008693 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 395095008694 ParB-like nuclease domain; Region: ParB; smart00470 395095008695 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 395095008696 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 395095008697 P-loop; other site 395095008698 Magnesium ion binding site [ion binding]; other site 395095008699 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 395095008700 Magnesium ion binding site [ion binding]; other site 395095008701 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 395095008702 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 395095008703 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 395095008704 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 395095008705 G-X-X-G motif; other site 395095008706 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 395095008707 RxxxH motif; other site 395095008708 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 395095008709 Uncharacterized conserved protein [Function unknown]; Region: COG0759 395095008710 ribonuclease P; Reviewed; Region: rnpA; PRK00588 395095008711 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399